Overview
Current Appointments & Affiliations
Professor Emeritus of Biochemistry
·
2023 - Present
Biochemistry,
Basic Science Departments
Recent Publications
The bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions.
Journal Article Acta Crystallogr D Struct Biol · December 1, 2023 Model building and refinement, and the validation of their correctness, are very effective and reliable at local resolutions better than about 2.5 Å for both crystallography and cryo-EM. However, at local resolutions worse than 2.5 Å both the procedures an ... Full text Link to item CiteThe importance of residue-level filtering and the Top2018 best-parts dataset of high-quality protein residues.
Journal Article Protein Sci · January 2022 We have curated a high-quality, "best-parts" reference dataset of about 3 million protein residues in about 15,000 PDB-format coordinate files, each containing only residues with good electron density support for a physically acceptable model conformation. ... Full text Open Access Link to item CiteImproving SARS-CoV-2 structures: Peer review by early coordinate release.
Journal Article Biophys J · March 16, 2021 This work builds upon the record-breaking speed and generous immediate release of new experimental three-dimensional structures of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and complexes, which are crucial to downstream vacc ... Full text Link to item CiteRecent Grants
PHENIX: New methods for automation in macromolecular crystallography
ResearchCollaborating Investigator · Awarded by Ernest Orlando Lawrence Berkeley National Laboratory · 2006 - 2023Extending MolProbity Diagnosis & Healing Methods to Empower Better CryoEM & Xray Models at 2.5-4A Resolution, plus Versioned, Redeposited "GEMS" for Important Individual Structures
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2023Bioinformatics and Computational Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021View All Grants
Education, Training & Certifications
Massachusetts Institute of Technology ·
1968
Ph.D.