Overview
Current Appointments & Affiliations
Professor Emeritus of Biochemistry
·
2023 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures: near-predictive, pseudostructure and barbed wire.
Journal Article Acta Crystallogr D Struct Biol · October 1, 2025 AlphaFold2 protein structure predictions are widely available for structural biology uses. These predictions, especially for eukaryotic proteins, frequently contain extensive regions predicted below the pLDDT = 70 level, the rule-of-thumb cutoff for high c ... Full text Link to item CiteCis-nonProline peptides: Genuine occurrences and their functional roles.
Journal Article Protein Sci · June 2025 While cis peptides preceding proline can occur about 5% of the time, cis peptides preceding any other residue ("cis-nonPro" peptides) are an extremely rare feature in protein structures, of considerable importance for two opposite reasons. On one hand, the ... Full text Link to item CiteThe bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions.
Journal Article Acta Crystallogr D Struct Biol · December 1, 2023 Model building and refinement, and the validation of their correctness, are very effective and reliable at local resolutions better than about 2.5 Å for both crystallography and cryo-EM. However, at local resolutions worse than 2.5 Å both the procedures an ... Full text Link to item CiteRecent Grants
PHENIX: New methods for automation in macromolecular crystallography
ResearchCollaborating Investigator · Awarded by Ernest Orlando Lawrence Berkeley National Laboratory · 2006 - 2023Extending MolProbity Diagnosis & Healing Methods to Empower Better CryoEM & Xray Models at 2.5-4A Resolution, plus Versioned, Redeposited "GEMS" for Important Individual Structures
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2023Bioinformatics and Computational Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021View All Grants
Education, Training & Certifications
Massachusetts Institute of Technology ·
1968
Ph.D.