Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Hematology-Oncology, Medicine, Duke University 1988 - 1991
  • Resident, Medicine, University of Texas at Dallas 1985 - 1988
  • M.D., University of Texas at Dallas 1985
• 

  Previous Appointments & Affiliations

  • Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2017 - 2020
  • Professor of Medicine, Medicine, Hematological Malignancies, Medicine 2012 - 2017
  • Professor of Medicine, Medicine, Medical Oncology, Medicine 2010 - 2012
  • Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2006 - 2010
  • Associate Clinical Professor of Medicine, Medicine, Medical Oncology, Medicine 2004 - 2006
  • Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 1994 - 2004
  • Associate in the Department of Medicine, Medicine, Medical Oncology, Medicine 1991 - 1994
• Research
• 

  Selected Grants

  • Novartis: Single-Arm, Open-Label, Ph2 of MBG453 added to Hypomethylating Agent for MDS awarded by Novartis Pharmaceuticals Corporation 2022 - 2026
  • A Phase 3 Study of Danicopan (ALXN2040) as Add-on Therapy to a C5 Inhibitor (Eculizumab or Ravulizumab) in Patients with Paroxysmal awarded by Alexion Pharmaceuticals, Inc. 2021 - 2026
  • Apellis AP2-307--Extension PNH awarded by Apellis Pharmaceuticals, Inc 2020 - 2025
  • EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health 2017 - 2024
  • A randomized, multicenter, active-comparator controlled, open-label trial to evaluate efficacy and safety of oral, twice daily LNP023 in adult patients with PNH and residual anemia, despite treatment with intravenous anti-C5 antibody awarded by Novartis Pharmaceuticals Corporation 2021 - 2024
  • A Phase III, Randomized, Multi-Center, Open-Label, Active-Comparator Controlled Study To Evaluate the Efficacy and Safety of APL-2 in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) awarded by Apellis Pharmaceuticals, Inc 2019 - 2024
  • EQAPOL OPTION 4 (YEAR 5 09/30/2021 - 09/29/2022) awarded by National Institutes of Health 2017 - 2022
  • A randomized, double-blind phase 3 study of vadastuximab talirine (SGN-CD33A) versus placebo in combination with azacitidine or decitabine in the treatment of older patients with newly diagnosed acute myeloid leukemia (AML) awarded by Seattle Genetics, Inc 2016 - 2021
  • A Phase 3, Double-Blind, Placebo-controlled study of Quizartinib (AC220) Administered in Combination with Induction and Consolidation Chemotherapy, and Administered as Maintenance Therapy in Subjects 18 to 75 Years Old with Newly Diagnosed FLT3-ITD awarded by Daiichi Sankyo Inc 2016 - 2021
  • Strategies to overcome immunotherapy resistance in LKB1 and KEAP/NRF2 mutated NSCLC: modulating ferroptosis to restore immune sensitivity awarded by Society for Immunotherapy of Cancer 2020 - 2021
  • Phase II study to evaluate safety of Azacitidine PLUS Durvalumab (medi4736) in MDS/AML awarded by Celgene Corporation 2016 - 2021
  • An Open Label study to assess the safety of APL-2 as an Add-on to standard of care in subjects with PNH awarded by Apellis Pharmaceuticals, Inc 2014 - 2019
  • A Phase 1b/2 Study of Entospletinib (GS-9973) Monotherapy and in Combination with Chemotherapy in Patients with Acute Myeloid Leukemia (AML) awarded by Gilead Sciences, Inc. 2017 - 2019
  • Phase III study of AG-221(CC-90007) with late AML harboring Isocitrate Dehydrogenase 2 mutation awarded by Celgene Corporation 2016 - 2019
  • RA101495-01.203: A Phase 2 Multicenter, Open-Label, Uncontrolled Study to Evaluate the Safety, Tolerability, Efficacy, Pharmaqcokinetics, and Pharm awarded by Ra Pharmaceuticals, Inc 2017 - 2018
  • RA101495-01.202: A multicenter, Open-Label, Uncontrolled, Extension Study of RA101495 in Subjects with Paroxysmal Nocturnal Hemoglobinuria Who Have Completed a RA101495 Clinical Study awarded by Ra Pharmaceuticals, Inc 2017 - 2018
  • A Study to Evaluate Imetelstat (JNJ-63935937) in Transfusion-Dependent subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) that is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment awarded by Janssen Research & Development, LLC 2016 - 2018
  • A Phase 2, Randomized, Controlled, Open-Label, Clinical Study of the Efficacy and Safety of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Patients with Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia awarded by Millennium Pharmaceuticals, Inc. 2016 - 2018
  • A Phase 3, Randomized, Open-Label, Active-Controlled Study of ALXN1210 Versus Eculizumab in Complement Inhibitor-Naive Adult Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) awarded by Alexion Pharmaceuticals, Inc. 2017
  • EQAPOL - 2016 to 2017 - Option 6 - BASE awarded by National Institutes of Health 2010 - 2017
  • EQAPOL Option 5 awarded by National Institutes of Health 2010 - 2017
  • Role Of C-Kit In Early Hematopoiesis awarded by National Institutes of Health 1991 - 1996
• 

  External Relationships

  • Apellis Pharmaceuticals
  • BioCryst Pharmaceuticals
  • Novartis
  • Regeneron Pharmaceuticals
  • Taiho
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Pabon, Cindy M., Zhiguo Li, Therese Hennig, Carlos de Castro, Jadee L. Neff, Mitchell E. Horwitz, Thomas W. LeBlanc, et al. “Morphologic leukemia-free state in acute myeloid leukemia is sufficient for successful allogeneic hematopoietic stem cell transplant.” Blood Cancer J 11, no. 5 (May 16, 2021): 92. https://doi.org/10.1038/s41408-021-00481-9.
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    • Sung, Anthony D., Shekeab Jauhari, Sharareh Siamakpour-Reihani, Arati V. Rao, Janet Staats, Cliburn Chan, Everett Meyer, et al. “Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects.” Am J Hematol 95, no. 6 (June 2020): 662–71. https://doi.org/10.1002/ajh.25781.
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    • Hudson, Kathryn E., David Rizzieri, Samantha M. Thomas, Thomas W. LeBlanc, Zachary Powell, Louis Diehl, Joseph O. Moore, Carlos DeCastro, and Anne W. Beaven. “Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study.” Br J Haematol 184, no. 4 (February 2019): 647–50. https://doi.org/10.1111/bjh.15138.
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    • Heyman, Benjamin, David Rizzieri, David J. Adams, Carlos De Castro, Louis Diehl, Zhiguo Li, Joseph Moore, and Anne Beaven. “Phase I Study of the Combination of Bendamustine, Rituximab, and Pixantrone in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma.” Clin Lymphoma Myeloma Leuk 18, no. 10 (October 2018): 679–86. https://doi.org/10.1016/j.clml.2018.07.285.
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    • Troy, Jesse D., Carlos M. de Castro, Mary Ruth Pupa, Greg P. Samsa, Amy P. Abernethy, and Thomas W. LeBlanc. “Patient-Reported Distress in Myelodysplastic Syndromes and Its Association With Clinical Outcomes: A Retrospective Cohort Study.” J Natl Compr Canc Netw 16, no. 3 (March 2018): 267–73. https://doi.org/10.6004/jnccn.2017.7048.
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    • Tuchman, Sascha A., Joseph O. Moore, Carlos D. DeCastro, Zhiguo Li, Emily Sellars, Yubin Kang, Gwynn Long, and Cristina G. Gasparetto. “Phase II study of dose-attenuated bortezomib, cyclophosphamide and dexamethasone ("VCD-Lite") in very old or otherwise toxicity-vulnerable adults with newly diagnosed multiple myeloma.” J Geriatr Oncol 8, no. 3 (May 2017): 165–69. https://doi.org/10.1016/j.jgo.2017.02.004.
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    • Greenberg, Peter L., Richard M. Stone, Aref Al-Kali, Stefan K. Barta, Rafael Bejar, John M. Bennett, Hetty Carraway, et al. “Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 15, no. 1 (January 2017): 60–87. https://doi.org/10.6004/jnccn.2017.0007.
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    • Griffin, Patrick T., Rami S. Komrokji, Carlos M. De Castro, David A. Rizzieri, Magda Melchert, Alan F. List, and Jeffrey E. Lancet. “A multicenter, phase II study of maintenance azacitidine in older patients with acute myeloid leukemia in complete remission after induction chemotherapy.” Am J Hematol 90, no. 9 (September 2015): 796–99. https://doi.org/10.1002/ajh.24087.
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    • Greenberg, Peter L., Richard M. Stone, Rafael Bejar, John M. Bennett, Clara D. Bloomfield, Uma Borate, Carlos M. De Castro, et al. “Myelodysplastic syndromes, version 2.2015.” J Natl Compr Canc Netw 13, no. 3 (March 2015): 261–72. https://doi.org/10.6004/jnccn.2015.0038.
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    • Brander, Danielle, David Rizzieri, Jon Gockerman, Louis Diehl, Thomas Charles Shea, Carlos Decastro, Joseph O. Moore, and Anne Beaven. “Phase II open label study of the oral vascular endothelial growth factor-receptor inhibitor PTK787/ZK222584 (vatalanib) in adult patients with refractory or relapsed diffuse large B-cell lymphoma.” Leuk Lymphoma 54, no. 12 (December 2013): 2627–30. https://doi.org/10.3109/10428194.2013.784969.
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    • Greenberg, Peter L., Eyal Attar, John M. Bennett, Clara D. Bloomfield, Uma Borate, Carlos M. De Castro, H Joachim Deeg, et al. “Myelodysplastic syndromes: clinical practice guidelines in oncology.” J Natl Compr Canc Netw 11, no. 7 (July 2013): 838–74. https://doi.org/10.6004/jnccn.2013.0104.
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    • Held, Lauren A., David Rizzieri, Gwynn D. Long, Jon P. Gockerman, Louis F. Diehl, Carlos M. de Castro, Joseph O. Moore, Mitchell E. Horwitz, Nelson J. Chao, and Cristina Gasparetto. “A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma.” Cancer Invest 31, no. 3 (March 2013): 172–76. https://doi.org/10.3109/07357907.2012.756109.
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    • Hillmen, P., P. Muus, A. Röth, M. O. Elebute, A. M. Risitano, H. Schrezenmeier, J. Szer, et al. “Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria.” British Journal of Haematology 162, no. 1 (2013): 62–73. https://doi.org/10.1111/bjh.12347.
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    • Morris, Tod A., Carlos M. DeCastro, Louis F. Diehl, Jon P. Gockerman, Anand S. Lagoo, Zhiguo Li, Joseph O. Moore, David A. Rizzieri, and Arati V. Rao. “Re-induction therapy decisions based on day 14 bone marrow biopsy in acute myeloid leukemia.” Leuk Res 37, no. 1 (January 2013): 28–31. https://doi.org/10.1016/j.leukres.2012.09.016.
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    • Rao, A. V., D. A. Rizzieri, C. M. DeCastro, L. F. Diehl, A. S. Lagoo, J. O. Moore, and J. P. Gockerman. “Phase I study of dose dense induction and consolidation with gemtuzumab ozogamicin and high dose cytarabine in older adults with AML.” Journal of Geriatric Oncology 3, no. 3 (July 1, 2012): 220–27. https://doi.org/10.1016/j.jgo.2012.02.002.
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    • Mohanty, Bibhu D., and Carlos M. De Castro. “Too many clots for comfort.” Am J Med 125, no. 3 (March 2012): 243–45. https://doi.org/10.1016/j.amjmed.2011.09.002.
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    • Lanasa, Mark C., Patricia H. Davis, Michael Datto, Zhiguo Li, Jon P. Gockerman, Joseph O. Moore, Carlos M. DeCastro, et al. “Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia.” Leuk Lymphoma 53, no. 2 (February 2012): 218–24. https://doi.org/10.3109/10428194.2011.610012.
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    • Christensen, Dale J., Youwei Chen, Jessica Oddo, Karen M. Matta, Jessica Neil, Evan D. Davis, Alicia D. Volkheimer, et al. “SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target.” Blood 118, no. 15 (October 13, 2011): 4150–58. https://doi.org/10.1182/blood-2011-04-351072.
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    • Greenberg, Peter L., Eyal Attar, John M. Bennett, Clara D. Bloomfield, Carlos M. De Castro, H Joachim Deeg, James M. Foran, et al. “NCCN Clinical Practice Guidelines in Oncology: myelodysplastic syndromes.” J Natl Compr Canc Netw 9, no. 1 (January 2011): 30–56. https://doi.org/10.6004/jnccn.2011.0005.
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    • Advani, Anjali S., Mazyar Shadman, Francis Ali-Osman, Andrew Barker, Lisa Rybicki, Matt Kalaycio, Mikkael A. Sekeres, et al. “A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse.” Clin Lymphoma Myeloma Leuk 10, no. 6 (December 2010): 473–76. https://doi.org/10.3816/CLML.2010.n.082.
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    • Dimopoulos, Meletios, Adrian Alegre, Edward A. Stadtmauer, Hartmut Goldschmidt, Jeffrey A. Zonder, Carlos M. de Castro, Zvenyslava Masliak, et al. “The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function.” Cancer 116, no. 16 (August 15, 2010): 3807–14. https://doi.org/10.1002/cncr.25139.
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    • Crout, Christopher A., Liang-Piu Koh, Jon P. Gockerman, Joseph O. Moore, Carlos Decastro, Gwynn D. Long, Louis Diehl, et al. “Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy.” Cancer Invest 28, no. 6 (July 2010): 654–60. https://doi.org/10.3109/07357901003631015.
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    • Gasparetto, Cristina, Jon P. Gockerman, Louis F. Diehl, Carlos M. de Castro, Joseph O. Moore, Gwynn D. Long, Mitchell E. Horwitz, et al. “"Short course" bortezomib plus melphalan and prednisone as induction prior to transplant or as frontline therapy for nontransplant candidates in patients with previously untreated multiple myeloma.” Biol Blood Marrow Transplant 16, no. 1 (January 2010): 70–77. https://doi.org/10.1016/j.bbmt.2009.08.017.
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    • Friedman, Daphne R., J Brice Weinberg, William T. Barry, Barbara K. Goodman, Alicia D. Volkheimer, Karen M. Bond, Youwei Chen, et al. “A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia.” Clin Cancer Res 15, no. 22 (November 15, 2009): 6947–55. https://doi.org/10.1158/1078-0432.CCR-09-1132.
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    • Frytak, Jennifer R., Henry J. Henk, Carlos M. De Castro, Rachel Halpern, and Michael Nelson. “Estimation of economic costs associated with transfusion dependence in adults with MDS.” Curr Med Res Opin 25, no. 8 (August 2009): 1941–51. https://doi.org/10.1185/03007990903076699.
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    • Rizzieri, David A., Jenny A. O’Brien, Gloria Broadwater, Carlos M. Decastro, Prakash Dev, Louis Diehl, Anne Beaven, et al. “Outcomes of patients who undergo aggressive induction therapy for secondary acute myeloid leukemia.” Cancer 115, no. 13 (July 1, 2009): 2922–29. https://doi.org/10.1002/cncr.24379.
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    • Castro, C. de, D. Adams, D. Rizzieri, J. Moore, J. Gockerman, L. Diehl, M. Horwitz, E. Edmonds, and J. Warzecho. “P134 A phase II pilot study of sorafenib in patients with myelodysplastic syndromes.” Leukemia Research 33, no. SUPPL. 1 (May 1, 2009). https://doi.org/10.1016/S0145-2126(09)70215-2.
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    • Castro, C. de, D. Adams, D. Rizzieri, J. Moore, J. Gockerman, L. Diehl, M. Horwitz, E. Edmonds, and J. Warzecho. “P129 A pilot study of decitabine in combination with arsenic trioxide for patients with myelodysplastic syndromes.” Leukemia Research 33, no. SUPPL. 1 (May 1, 2009). https://doi.org/10.1016/S0145-2126(09)70210-3.
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    • Grinblatt, David L., Daohai Yu, Vera Hars, James W. Vardiman, Bayard L. Powell, Sreenivasa Nattam, Lewis R. Silverman, et al. “Treatment of myelodysplastic syndrome with 2 schedules and doses of oral topotecan: a randomized phase 2 trial by the Cancer and Leukemia Group B (CALGB 19803).” Cancer 115, no. 1 (January 1, 2009): 84–93. https://doi.org/10.1002/cncr.23995.
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    • Weinberg, J. B., A. D. Volkheimer, M. Mihovilovic, N. Jiang, Y. Chen, K. Bond, J. O. Moore, et al. “Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia.” Leukemia 22, no. 12 (December 2008): 2184–92. https://doi.org/10.1038/leu.2008.241.
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    • Christensen, Dale J., Karen M. Bond, Alicia D. Volkheimer, Jessica Oddo, Youwei Chen, Jon P. Gockerrnan, Joseph O. Moore, et al. “Apolipoprotein E-Mimetic Therapeutic Peptides Mediate CLL Cell Cytotoxicity.” Blood 112, no. 11 (November 16, 2008): 140–140.
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    • Greenberg, Peter L., Eyal Attar, Minoo Battiwalla, John M. Bennett, Clara D. Bloomfield, Carlos M. DeCastro, H Joachim Deeg, et al. “Myelodysplastic syndromes.” J Natl Compr Canc Netw 6, no. 9 (October 2008): 902–26.
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    • Rao, Arati V., Islam R. Younis, Gregory J. Sand, Ivan Spasojevic, David J. Adams, Carlos M. Decastro, John P. Gockerman, et al. “Phase I evaluation of gemcitabine, mitoxantrone, and their effect on plasma disposition of fludarabine in patients with relapsed or refractory acute myeloid leukemia.” Leuk Lymphoma 49, no. 8 (August 2008): 1523–29. https://doi.org/10.1080/10428190802210700.
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    • Brodsky, Robert A., Neal S. Young, Elisabetta Antonioli, Antonio M. Risitano, Hubert Schrezenmeier, Jörg Schubert, Anna Gaya, et al. “Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.” Blood 111, no. 4 (February 15, 2008): 1840–47. https://doi.org/10.1182/blood-2007-06-094136.
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    • Weinberg, J Brice, Alicia D. Volkheimer, Youwei Chen, Bethany E. Beasley, Ning Jiang, Mark C. Lanasa, Daphne Friedman, et al. “Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia.” Am J Hematol 82, no. 12 (December 2007): 1063–70. https://doi.org/10.1002/ajh.20987.
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    • Fock, K. M., A. Wagner, M. A. Ahad, D. S. Ahmed, F. Ahmed, M. M. Ahmed, M. S. Ali, et al. “Safety, tolerability and satisfaction with tegaserod therapy in Asia-Pacific patients with irritable bowel syndrome with constipation.” Journal of Gastroenterology and Hepatology (Australia) 22, no. 8 (August 1, 2007): 1190–98. https://doi.org/10.1111/j.1440-1746.2007.04955.x.
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    • Frytak, J. R., H. J. Henk, C. M. de Castro, R. Halpern, and M. Nelson. “P132 Cost of transfusion dependency among managed care patients with myelodysplastic syndromes.” Leukemia Research 31 (May 2007): S111–12. https://doi.org/10.1016/s0145-2126(07)70202-3.
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    • Rizzieri, David A., Liang Piu Koh, Gwynn D. Long, Cristina Gasparetto, Keith M. Sullivan, Mitchell Horwitz, John Chute, et al. “Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution.” J Clin Oncol 25, no. 6 (February 20, 2007): 690–97. https://doi.org/10.1200/JCO.2006.07.0953.
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    • Anderson, Kenneth C., Melissa Alsina, William Bensinger, J Sybil Biermann, Asher Chanan-Khan, Raymond L. Comenzo, Carlos M. De Castro, et al. “Multiple myeloma. Clinical practice guidelines in oncology.” J Natl Compr Canc Netw 5, no. 2 (February 2007): 118–47. https://doi.org/10.6004/jnccn.2007.0014.
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    • Wanko, Sam O., and Carlos de Castro. “Hairy cell leukemia: an elusive but treatable disease.” Oncologist 11, no. 7 (July 2006): 780–89. https://doi.org/10.1634/theoncologist.11-7-780.
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    • Kantarjian, Hagop, Jean-Pierre J. Issa, Craig S. Rosenfeld, John M. Bennett, Maher Albitar, John DiPersio, Virginia Klimek, et al. “Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study.” Cancer 106, no. 8 (April 15, 2006): 1794–1803. https://doi.org/10.1002/cncr.21792.
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    • Greenberg, Peter L., Maria R. Baer, John M. Bennett, Clara D. Bloomfield, Carlos M. De Castro, H Joachim Deeg, Marcel P. Devetten, et al. “Myelodysplastic syndromes clinical practice guidelines in oncology.” J Natl Compr Canc Netw 4, no. 1 (January 2006): 58–77.
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    • Talbot, Jeffrey, Valerie K. Ibom, David A. Rizzieri, Robert Barrier, Donna Niedzwieki, Carlos M. DeCastro, Joseph O. Moore, et al. “Dose-intense cyclophosphamide and etoposide for patients with refractory or high-risk non-Hodgkin's lymphoma.” Clin Lymphoma 5, no. 2 (September 2004): 116–22. https://doi.org/10.3816/clm.2004.n.018.
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    • Rizzieri, David A., Gamal Akabani, Michael R. Zalutsky, R Edward Coleman, Scott D. Metzler, James E. Bowsher, Bonnie Toaso, et al. “Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma.” Blood 104, no. 3 (August 1, 2004): 642–48. https://doi.org/10.1182/blood-2003-12-4264.
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    • Rizzieri, David A., Gregory J. Sand, Dean McGaughey, Joseph O. Moore, Carlos DeCastro, Nelson J. Chao, James J. Vredenburgh, et al. “Low-dose weekly paclitaxel for recurrent or refractory aggressive non-Hodgkin lymphoma.” Cancer 100, no. 11 (June 1, 2004): 2408–14. https://doi.org/10.1002/cncr.20245.
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    • Nishimura, Jun-Ichi, Yuzuru Kanakura, Russell E. Ware, Tsutomu Shichishima, Hideki Nakakuma, Haruhiko Ninomiya, Carlos M. Decastro, et al. “Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan.” Medicine (Baltimore) 83, no. 3 (May 2004): 193–207. https://doi.org/10.1097/01.md.0000126763.68170.46.
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    • Ibom, Valerie K., Robert G. Prosnitz, Jerald Z. Gong, Joseph O. Moore, Carlos M. DeCastro, Leonard R. Prosnitz, David A. Rizzieri, and Jon P. Gockerman. “Rituximab in lymphocyte predominance Hodgkin's disease: a case series.” Clin Lymphoma 4, no. 2 (September 2003): 115–18. https://doi.org/10.3816/clm.2003.n.021.
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    • Talbot, Jeffrey, David A. Rizzieri, Carlos M. DeCastro, Joseph O. Moore, Patrick Buckley, Rhonda Laney, Diane Stevenson, Heather Brumbaugh, and Jon P. Gockerman. “High-dose cyclophosphamide and etoposide for patients with refractory acute myeloid leukemia: a case series.” Am J Hematol 73, no. 4 (August 2003): 295–96. https://doi.org/10.1002/ajh.10362.
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    • Heeney, Matthew M., Susan M. Ormsbee, M Anthony Moody, Thad A. Howard, Carlos M. DeCastro, and Russell E. Ware. “Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria.” Mol Genet Metab 78, no. 4 (April 2003): 291–94. https://doi.org/10.1016/s1096-7192(03)00047-7.
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    • Rizzieri, David A., Valerie K. Ibom, Joseph O. Moore, Carlos M. DeCastro, Gary L. Rosner, David J. Adams, Traci Foster, et al. “Phase I evaluation of prolonged-infusion gemcitabine with fludarabine for relapsed or refractory acute myelogenous leukemia.” Clin Cancer Res 9, no. 2 (February 2003): 663–68.
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    • Castro, Carlos M. de. “Commentary: targeting myelodysplastic syndromes.” Leuk Res 26, no. 8 (August 2002): 703. https://doi.org/10.1016/s0145-2126(02)00024-3.
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    • Bass, Adam J., Jon P. Gockerman, Eve Hammett, Carlos M. DeCastro, David J. Adams, Gary L. Rosner, Nancy Payne, et al. “Phase I evaluation of prolonged-infusion gemcitabine with irinotecan for relapsed or refractory leukemia or lymphoma.” J Clin Oncol 20, no. 13 (July 1, 2002): 2995–3000. https://doi.org/10.1200/JCO.2002.08.166.
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    • Kornblith, Alice B., James E. Herndon, Lewis R. Silverman, Erin P. Demakos, Rosalie Odchimar-Reissig, James F. Holland, Bayard L. Powell, et al. “Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study.” J Clin Oncol 20, no. 10 (May 15, 2002): 2441–52. https://doi.org/10.1200/JCO.2002.04.044.
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    • Silverman, Lewis R., Erin P. Demakos, Bercedis L. Peterson, Alice B. Kornblith, Jimmie C. Holland, Rosalie Odchimar-Reissig, Richard M. Stone, et al. “Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.” J Clin Oncol 20, no. 10 (May 15, 2002): 2429–40. https://doi.org/10.1200/JCO.2002.04.117.
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    • McCune, Steven L., Jon P. Gockerman, Joseph O. Moore, Carlos M. Decastro, Adam J. Bass, Nelson J. Chao, Gwynn D. Long, et al. “Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia.” Leuk Lymphoma 43, no. 5 (May 2002): 1007–11. https://doi.org/10.1080/10428190290021597.
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    • Rizzieri, David A., Adam J. Bass, Gary L. Rosner, Jon P. Gockerman, Carlos M. DeCastro, William P. Petros, David J. Adams, et al. “Phase I evaluation of prolonged-infusion gemcitabine with mitoxantrone for relapsed or refractory acute leukemia.” J Clin Oncol 20, no. 3 (February 1, 2002): 674–79. https://doi.org/10.1200/JCO.2002.20.3.674.
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    • Ware, R. E., C. V. Pickens, C. M. DeCastro, and T. A. Howard. “Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes.” Exp Hematol 29, no. 12 (December 2001): 1403–9. https://doi.org/10.1016/s0301-472x(01)00746-9.
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    • Rizzieri, D. A., J. P. Gockerman, C. M. Decastro, S. Lilly, and T. Foster. “Phase i trial of continuously infused gemcitabine with cpt-11 for refractory hematologic malignancies.” Blood 96, no. 11 PART II (December 1, 2000).
    • Ware, R. E., C. V. Pickens, C. M. Decastro, and T. A. Howard. “Circulating pig-a mutant t lymphocytes in healthy adults and patients with bone marrow failure syndromes including pnh.” Blood 96, no. 11 PART I (December 1, 2000).
    • Mann, K. P., C. M. DeCastro, J. Liu, J. O. Moore, S. H. Bigner, and S. T. Traweek. “Neural cell adhesion molecule (CD56)-positive acute myelogenous leukemia and myelodysplastic and myeloproliferative syndromes.” Am J Clin Pathol 107, no. 6 (June 1997): 653–60. https://doi.org/10.1093/ajcp/107.6.653.
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    • Castro, C. M. de, S. M. Rabe, S. D. Langdon, D. E. Fleenor, K. Slentz-Kesler, M. N. Ahmed, M. B. Qumsiyeh, and R. E. Kaufman. “Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).” Genomics 42, no. 2 (June 1, 1997): 227–35. https://doi.org/10.1006/geno.1997.4730.
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    • He, J., C. M. deCastro, G. R. Vandenbark, J. Busciglio, and D. Gabuzda. “Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene.” Proc Natl Acad Sci U S A 94, no. 8 (April 15, 1997): 3954–59. https://doi.org/10.1073/pnas.94.8.3954.
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    • Wuebbens, M. W., E. D. Roush, C. M. Decastro, and C. A. Fierke. “Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family.” Biochemistry 36, no. 14 (April 8, 1997): 4327–36. https://doi.org/10.1021/bi9627424.
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    • Fleenor, D. E., S. D. Langdon, C. M. deCastro, and R. E. Kaufman. “Comparison of human and Xenopus GATA-2 promoters.” Gene 179, no. 2 (November 14, 1996): 219–23. https://doi.org/10.1016/s0378-1119(96)00355-1.
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    • Vandenbark, G. R., Y. Chen, E. Friday, K. Pavlik, B. Anthony, C. deCastro, and R. E. Kaufman. “Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements.” Cell Growth Differ 7, no. 10 (October 1996): 1383–92.
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    • deCastro, C. M., S. M. Denning, S. Langdon, G. R. Vandenbark, J. Kurtzberg, R. Scearce, B. F. Haynes, and R. E. Kaufman. “The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes.” Exp Hematol 22, no. 10 (September 1994): 1025–33.
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    • Castro, C. M. de, B. Devlin, D. E. Fleenor, M. E. Lee, and R. E. Kaufman. “A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype.” Blood 83, no. 4 (February 15, 1994): 1109–16.
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    • Bowen, D. T., R. A. Padua, A. K. Burnett, C. M. DeCastro, and R. E. Kaufman. “Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots.” Leukemia 7, no. 11 (January 1, 1993): 1883–85.
    • Vandenbark, G. R., C. M. deCastro, H. Taylor, S. Dew-Knight, and R. E. Kaufman. “Cloning and structural analysis of the human c-kit gene.” Oncogene 7, no. 7 (July 1992): 1259–66.
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  • Conference Papers

    • De latour, Regis Peffault, Carlos M. De Castro, Jeffrey Szer, Kensuke Usuki, Peter Hillmen, Morag Griffin, Mohamed Hamdani, Temitayo Ajayi, Hisakazu Nishimori, and Ilene C. Weitz. “"Superiority of Pegcetacoplan Compared to Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria, Regardless of Prior Transfusion Requirement: Analysis at 16-weeks of PEGASUS Phase 3 Randomized Trial".” In British Journal of Haematology, 193:189–90, 2021.
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    • Griffin, Morag, Peter Hillmen, Jeffrey Szer, Ilene C. Weitz, Alexander Roeth, Britta Hoechsmann, Jens Panse, et al. “Results of the Pegasus Phase 3 Randomized Trial Demonstrating Superiority of the C3 Inhibitor, Pegcetacoplan, Compared to Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria.” In British Journal of Haematology, 193:63–65, 2021.
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    • Risitano, Antonio, Ilene C. Weitz, Carlos M. De Castro, Jean-Jacques Kiladjian, Morag Griffin, Hisakazu Nishimori, Mohamed Hamdani, Temitayo Ajayi, Scott B. Baver, and Regis Peffault de Latour. “Categorized hematologic response to pegcetacoplan versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria: post hoc analysis of data from a phase 3 randomized trial (PEGASUS).” In British Journal of Haematology, 193:24–25, 2021.
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    • Roeth, Alexander, Britta Hoechsmann, Morag Griffin, Carlos M. De Castro, Jeffrey Szer, Kensuke Usuki, Juliette Soret, et al. “Effect of Pegcetacoplan on Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria from the Pegasus Phase 3 Trial Comparing Pegcetacoplan to Eculizumab.” In British Journal of Haematology, 193:198–99, 2021.
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    • Sung, Anthony D., Carlos M. de Castro, Thomas W. LeBlanc, Gwynn D. Long, Donna B. Adams, Danielle M. Brander, Sandeep Dave, et al. “Clinical Outcomes of Microtransplantation for Older Adults with Acute Myeloid Leukemia.” In Blood, Vol. 130. AMER SOC HEMATOLOGY, 2017.
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    • Hillmen, Peter, Petra Muus, Alexander Röth, Modupe O. Elebute, Antonio M. Risitano, Hubert Schrezenmeier, Jeffrey Szer, et al. “Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria.” In Br J Haematol, 162:62–73, 2013. https://doi.org/10.1111/bjh.12347.
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    • Beaven, Anne W., David A. Rizzieri, Zachary Powell, Zhiguo Li, Peggy Alton, Julie Warzecho, Louis F. Diehl, Joseph O. Moore, Carlos Manuel de Castro, and Jon P. Gockerman. “High Complete Response Rates with Dose Dense/Dose Intense Chemotherapy Plus Radioimmunotherapy in High Risk Diffuse Large B Cell and Mantle Cell Lymphoma.” In Blood, 118:1152–1152. AMER SOC HEMATOLOGY, 2011.
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    • Morris, Tod A., David A. Rizzieri, Carlos M. de Castro, Louis F. Diehl, Jon P. Gockerman, Anand S. Lagoo, Joseph O. Moore, and Arati V. Rao. “Re-Induction Therapy Decisions Based on Day 14 Bone Marrow Biopsy in Acute Myeloid Leukemia.” In Blood, 118:1532–33. AMER SOC HEMATOLOGY, 2011.
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    • Christensen, Dale J., Karen M. Bond, Alicia D. Volkheimer, Jessica Oddo, Youwei Chen, Jon P. Gockerman, Joseph O. Moore, et al. “The SET Oncogene, a Potent PP2A Inhibitor, Is Elevated in CLL and Antagonism of SET Induces Apoptosis.” In Blood, 114:802–802. American Society of Hematology, 2009. https://doi.org/10.1182/blood.v114.22.802.802.
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    • Lancet, Jeffrey E., Rami S. Komrokji, HuiYi Lin, Carlos M. de Castro, David A. Rizzieri, Magda Melchert, and Alan F. List. “Maintenance Therapy with Low-Dose Subcutaneous 5-Azacitidine in Older Patients with AML in 1st Remission.” In Blood, 114:425–26. AMER SOC HEMATOLOGY, 2009.
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    • Chi, Jen-Tsan Ashley, Carolyn Sangokoya, and Carlos M. De Castro. “MicroRNA expression in red blood cells from patients with PNH.” In Blood, 110:1073A-1073A. AMER SOC HEMATOLOGY, 2007.
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    • Weinberg, J Brice, Alicia D. Volkheimer, Mirta Mihovilovic, Ning Jiang, Youwei Chen, Joseph O. Moore, Jon P. Gockerman, et al. “Apolipoprotein E (APOE) Genotype as a Determinant of Survival in Women with Chronic Lymphocytic Leukemia.” In Blood, 110:3081–3081. American Society of Hematology, 2007. https://doi.org/10.1182/blood.v110.11.3081.3081.
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    • Weinberg, J Brice, Ning Jiang, Alicia D. Volkheimer, Youwei Chen, Karen M. Bond, Joseph O. Moore, Jon P. Gockerman, et al. “Cytotoxicity of the Type 4 Phosphodiesterase Inhibitor CD160130 for Freshly Isolated Human CLL Cells In Vitro.” In Blood, 110:3129–3129. American Society of Hematology, 2007. https://doi.org/10.1182/blood.v110.11.3129.3129.
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    • Silverman, L. R., D. R. McKenzie, B. L. Peterson, C. M. De Castro, J. Ellerton, K. N. Knapp, C. L. Beach, and R. A. Larson. “Response rates using international working group (IWG) criteria in patients with myelodysplastic syndromes (MDS) treated with azacitidine.” In Blood, 106:709A-709A. AMER SOC HEMATOLOGY, 2005.
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    • Gasparetto, Cristina, Mitchell E. Horwitz, Jon P. Gockerman, Carlos M. de Castro, Joseph O. Moore, Clay A. Smith, Patty Davis, et al. “Campath-1H May Have Activity in the Treatment of Multiple Myeloma.” In Blood, 104:4931–4931. American Society of Hematology, 2004. https://doi.org/10.1182/blood.v104.11.4931.4931.
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    • Castro, C. M. de, H. Uronis, J. O. Moore, J. P. Gockerman, D. A. Rizzieri, and N. J. Chao. “Successful treatment of pure red cell aplasia (PRCA) with alemtuzumab (CAMPATH-1H).” In Blood, 102:19B-19B. AMER SOC HEMATOLOGY, 2003.
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• Teaching & Mentoring
• 

  Recent Courses

  • MEDICINE 402C: Medical Sub-Internship in Hematology-Oncology 2021
  • MEDICINE 425C: Clinical Coagulation 2021
  • MEDICINE 402C: Medical Sub-Internship in Hematology-Oncology 2020
  • MEDICINE 425C: Clinical Coagulation 2020
  • MEDICINE 434C: Outpatient Hematology-Oncology (Duke or Durham VA) 2020
  • MEDICINE 438C: Clinical Hematology and Oncology Consults (Duke or Durham VA) 2020

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