Overview
Current Appointments & Affiliations
Professor of Medicine
·
2021 - Present
Medicine, Hematologic Malignancies and Cellular Therapy,
Medicine
Member of the Duke Cancer Institute
·
1988 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Patient-reported improvements in paroxysmal nocturnal hemoglobinuria treated with iptacopan from 2 phase 3 studies.
Journal Article Blood Adv · April 22, 2025 Iptacopan, a first-in-class, oral, selective complement factor B inhibitor, demonstrated efficacy and safety as monotherapy in C5 inhibitor (C5i)-experienced (APPLY-PNH; NCT04558918) and C5i-naive (APPOINT-PNH; NCT04820530) patients with paroxysmal nocturn ... Full text Link to item CiteModified Delphi panel consensus recommendations for management of severe aplastic anemia.
Journal Article Blood Adv · August 13, 2024 Severe aplastic anemia (SAA) is a rare hematologic condition for which there is no clear management algorithm. A panel of 11 experts on adult and pediatric aplastic anemia was assembled and, using the RAND/University of California, Los Angeles modified Del ... Full text Link to item CiteHemolysis events in the phase 3 PEGASUS study of pegcetacoplan in patients with paroxysmal nocturnal hemoglobinuria.
Journal Article Blood Adv · June 11, 2024 Patients with paroxysmal nocturnal hemoglobinuria (PNH) experience complement-mediated intravascular hemolysis leading to anemia, fatigue, and potentially life-threatening thrombotic complications. Pegcetacoplan, a C3 inhibitor, demonstrated sustained impr ... Full text Link to item CiteRecent Grants
External Quality Assurance Program Oversight Laboratory (EQAPOL)
ResearchInvestigator · Awarded by National Institutes of Health · 2024 - 2031Novartis: Single-Arm, Open-Label, Ph2 of MBG453 added to Hypomethylating Agent for MDS
Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2022 - 2026CLNP023C12303
Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2023 - 2026View All Grants
Education, Training & Certifications
University of Texas, Dallas ·
1985
M.D.