Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Hematology and Oncology, Medicine, Yale University 1995 - 1998
  • Medical Resident, Medicine, Montefiore Medical Center 1992 - 1995
  • M.D., Universidad Autonoma de Santo Domingo (Dominican Republic) 1986
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Hematology, Medicine 2011 - 2013
  • Assistant Professor of Medicine, Medicine, Hematology, Medicine 2004 - 2010
  • Associate in the Department of Medicine, Medicine, Hematology, Medicine 1998 - 2004
• Research
• 

  Selected Grants

  • Hematopoietic Cell Therapy for Young Adults with Severe Sickle Cell Disease awarded by University of Pittsburgh 2011 - 2014
  • Phase II Study of Propranolol as Anti-Adhesive Therapy in SCD awarded by National Institutes of Health 2009 - 2013
  • PROPRANOLOL AS ANTI-ADHESIVE THERAPY IN SCD awarded by National Institutes of Health 2010 - 2012
  • Relationship of Depression to SCD Severity, Health Care Utilization and QoL awarded by Agency for Healthcare Research and Quality 2008 - 2011
  • Pulmonary Hypertension in SCD awarded by National Institutes of Health 2005 - 2011
  • Factors Involved in B-CAM/LU-Mediated Adhesion awarded by National Institutes of Health 1999 - 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Elmariah, H, Garrett, ME, De Castro, LM, Jonassaint, JC, Ataga, KI, Eckman, JR, Ashley-Koch, AE, and Telen, MJ. "Factors associated with survival in a contemporary adult sickle cell disease cohort." American journal of hematology 89, no. 5 (May 2014): 530-535.  Full Text
    • Klings, ES, Machado, RF, Barst, RJ, Morris, CR, Mubarak, KK, Gordeuk, VR, Kato, GJ, Ataga, KI, Gibbs, JS, Castro, O, Rosenzweig, EB, Sood, N, Hsu, L, Wilson, KC, Telen, MJ, Decastro, LM, Krishnamurti, L, Steinberg, MH, Badesch, DB, Gladwin, MT, and American Thoracic Society Ad Hoc Committee on Pulmonary Hypertension of Sickle Cell Disease, . "An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease." American journal of respiratory and critical care medicine 189, no. 6 (March 2014): 727-740.  Full Text
    • Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and De Castro, LM. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." Clin J Pain 30, no. 3 (March 2014): 266-268.  Full Text  Link to Item
    • Edwards, CL, Killough, A, Wood, M, Doyle, T, Feliu, M, Barker, CS, Uppal, P, DeCastro, L, Wellington, C, Whitfield, KE, O'Garo, K-GN, Morgan, K, Edwards Alesii, LY, Byrd, GS, McCabe, M, Goli, V, Keys, A, Hill, L, Collins-McNeil, J, Trambadia, J, Guinyard, D, Muhammad, M, McDonald, P, Schmechel, DE, and Robinson, E. "Emotional reactions to pain predict psychological distress in adult patients with Sickle Cell Disease (SCD)." International journal of psychiatry in medicine 47, no. 1 (January 2014): 1-16.  Full Text
    • Elmariah, H, Garrett, ME, De Castro, LM, Jonassaint, JC, Ataga, KI, Eckman, JR, Ashley-Koch, AE, and Telen, MJ. "Factors associated with survival in a contemporary adult sickle cell disease cohort." American Journal of Hematology 89, no. 5 (January 1, 2014): 530-535.  Full Text
    • Shah, N, Jonassaint, J, and De Castro, L. "Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART)." Hemoglobin 38, no. 2 (January 2014): 99-103.  Full Text
    • Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and Castro, LMD. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." Clinical Journal of Pain 30, no. 3 (2014): 266-268.  Full Text
    • Tanabe, P, Stevenson, A, DeCastro, L, Drawhorn, L, Lanzkron, S, Molokie, RE, and Artz, N. "Evaluation of a train-the-trainer workshop on sickle cell disease for ED providers." Journal of Emergency Nursing 39, no. 6 (2013): 539-546.  Full Text
    • De Castro, LM, Zennadi, R, Jonassaint, JC, Batchvarova, M, and Telen, MJ. "Effect of propranolol as antiadhesive therapy in sickle cell disease." Clin Transl Sci 5, no. 6 (December 2012): 437-444.  Full Text  Link to Item
    • Shah, N, Landi, D, Shah, R, Rothman, J, De Castro, LM, and Thornburg, CD. "Complications of implantable venous access devices in patients with sickle cell disease." Am J Hematol 87, no. 2 (February 2012): 224-226.  Full Text  Link to Item
    • Ashley-Koch, AE, Okocha, EC, Garrett, ME, Soldano, K, De Castro, LM, Jonassaint, JC, Orringer, EP, Eckman, JR, and Telen, MJ. "MYH9 and APOL1 are both associated with sickle cell disease nephropathy." Br J Haematol 155, no. 3 (November 2011): 386-394.  Full Text  Link to Item
    • Royal, CD, Jonassaint, CR, Jonassaint, JC, and De Castro, LM. "Living with sickle cell disease: traversing 'race' and identity." Ethnicity & health 16, no. 4-5 (August 2011): 389-404.  Full Text
    • Jonassaint, CR, Jonassaint, JC, Stanton, MV, De Castro, LM, and Royal, CD. "Clinical and sociodemographic factors predict coping styles among adults with sickle cell disease." Journal of the National Medical Association 102, no. 11 (November 2010): 1045-1049.
    • Stanton, MV, Jonassaint, CR, Bartholomew, FB, Edwards, C, Richman, L, DeCastro, L, and Williams, R. "The association of optimism and perceived discrimination with health care utilization in adults with sickle cell disease." J Natl Med Assoc 102, no. 11 (November 2010): 1056-1063.  Link to Item
    • Vichinsky, EP, Neumayr, LD, Gold, JI, Weiner, MW, Rule, RR, Truran, D, Kasten, J, Eggleston, B, Kesler, K, McMahon, L, Orringer, EP, Harrington, T, Kalinyak, K, De Castro, LM, Kutlar, A, Rutherford, CJ, Johnson, C, Bessman, JD, Jordan, LB, Armstrong, FD, and Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group, . "Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia." JAMA 303, no. 18 (May 12, 2010): 1823-1831.  Full Text  Link to Item
    • Brittain, JE, Hulkower, B, Jones, SK, Strayhorn, D, De Castro, L, Telen, MJ, Orringer, EP, Hinderliter, A, and Ataga, KI. "Placenta growth factor in sickle cell disease: association with hemolysis and inflammation." Blood 115, no. 10 (March 11, 2010): 2014-2020.  Full Text  Link to Item
    • Adam, SS, Telen, MJ, Jonassaint, CR, Castro, LMD, and Jonassaint, JC. "The relationship of opioid analgesia to quality of life in an adult sickle cell population." Health Outcomes Research in Medicine 1, no. 1 (2010): e29-e37.  Full Text
    • Fitzhugh, CD, Lauder, N, Jonassaint, JC, Telen, MJ, Zhao, X, Wright, EC, Gilliam, FR, and De Castro, LM. "Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease." Am J Hematol 85, no. 1 (January 2010): 36-40.  Full Text  Link to Item
    • Steinberg, MH, McCarthy, WF, Castro, O, Ballas, SK, Armstrong, FD, Smith, W, Ataga, K, Swerdlow, P, Kutlar, A, DeCastro, L, Waclawiw, MA, Orringer, E, Jones, S, Strayhorn, D, Rosse, W, Phillips, G, Peace, D, Johnson-Telfair, A, Daitch, L, Milner, P, Tracy, A, Valdez, S, Allen, GE, Moshang, J, Scott, B, Bigelow, C, Anderson, A, Sabahi, V, Harrington, T, Labrousse, W, Pegelow, C, Temple, D, Case, E, Harrell, R, Childerie, S, Embury, S, Schmidt, B, Davies, D, Saunthararajah, Y, and Koshy, M et al. "The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up." American Journal of Hematology 85, no. 6 (2010): 403-408.  Full Text
    • Edwards, CL, Green, M, Wellington, CC, Muhammad, M, Wood, M, Feliu, M, Edwards, L, Hill, L, Sollers, JJ, Barksdale, C, Robinson, EL, McDougald, CS, Abrams, M, Whitfield, KE, Byrd, G, Hubbard, B, Cola, M, DeCastro, L, and McNeil, J. "Depression, suicidal ideation, and attempts in black patients with sickle cell disease." J Natl Med Assoc 101, no. 11 (November 2009): 1090-1095.  Link to Item
    • Ballas, SK, McCarthy, WF, Guo, N, DeCastro, L, Bellevue, R, Barton, BA, and Waclawiw, MA. "Exposure to hydroxyurea and pregnancy outcomes in patients with sickle cell anemia." Journal of the National Medical Association 101, no. 10 (2009): 1046-1051.
    • Adam, S, Jonassaint, J, Kruger, H, Kail, M, Orringer, EP, Eckman, JR, Ashley-Koch, A, Telen, MJ, and De Castro, LM. "Surgical and obstetric outcomes in adults with sickle cell disease." Am J Med 121, no. 10 (October 2008): 916-921.  Full Text  Link to Item
    • Villers, MS, Jamison, MG, De Castro, LM, and James, AH. "Morbidity associated with sickle cell disease in pregnancy." Am J Obstet Gynecol 199, no. 2 (August 2008): 125.e1-125.e5.  Full Text  Link to Item
    • Ashley-Koch, AE, Elliott, L, Kail, ME, De Castro, LM, Jonassaint, J, Jackson, TL, Price, J, Ataga, KI, Levesque, MC, Weinberg, JB, Orringer, EP, Collins, A, Vance, JM, and Telen, MJ. "Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease." Blood 111, no. 12 (June 15, 2008): 5721-5726.  Full Text  Link to Item
    • Ataga, KI, Smith, WR, De Castro, LM, Swerdlow, P, Saunthararajah, Y, Castro, O, Vichinsky, E, Kutlar, A, Orringer, EP, Rigdon, GC, Stocker, JW, and ICA-17043-05 Investigators, . "Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia." Blood 111, no. 8 (April 15, 2008): 3991-3997.  Full Text  Link to Item
    • Eyler, CE, Jackson, T, Elliott, LE, De Castro, LM, Jonassaint, J, Ashley-Koch, A, and Telen, MJ. "beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion." Br J Haematol 141, no. 1 (April 2008): 105-108.  Full Text  Link to Item
    • Zennadi, R, De Castro, L, Eyler, C, Xu, K, Ko, M, and Telen, MJ. "Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors." Transfus Clin Biol 15, no. 1-2 (February 2008): 23-28.  Full Text  Link to Item
    • De Castro, LM, Jonassaint, JC, Graham, FL, Ashley-Koch, A, and Telen, MJ. "Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes." Am J Hematol 83, no. 1 (January 2008): 19-25.  Full Text  Link to Item
    • Fung, EB, Harmatz, PR, Milet, M, Balasa, V, Ballas, SK, Casella, JF, Hilliard, L, Kutlar, A, McClain, KL, Olivieri, NF, Porter, JB, Vichinsky, EP, Bellevue, R, Coates, T, Darbari, D, Davis, C, DeCastro, L, Giardina, P, Hord, J, Jeng, M, Kirby, M, Mignaca, R, Mentzer, W, Olivieri, N, Owen, W, Pegelow, C, Porter, J, Ramirez, G, Ranalli, M, Rao, S, Scher, C, Shafer, F, Smith, MG, Smith-Whitney, K, Thompson, A, and Wang, W. "Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions." Transfusion 48, no. 9 (2008): 1971-1980.  Full Text
    • Edwards, CL, Raynor, RD, Feliu, M, McDougald, C, Johnson, S, Schmechel, D, Wood, M, Bennett, GG, Saurona, P, Bonner, M, Wellington, C, DeCastro, LM, Whitworth, E, Abrams, M, Logue, P, Edwards, L, Martinez, S, and Whitfield, KE. "Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD)." Neuropsychiatr Dis Treat 3, no. 6 (December 2007): 705-709.  Link to Item
    • Elliott, L, Ashley-Koch, AE, De Castro, L, Jonassaint, J, Price, J, Ataga, KI, Levesque, MC, Brice Weinberg, J, Eckman, JR, Orringer, EP, Vance, JM, and Telen, MJ. "Genetic polymorphisms associated with priapism in sickle cell disease." Br J Haematol 137, no. 3 (May 2007): 262-267.  Full Text  Link to Item
    • Fung, EB, Harmatz, P, Milet, M, Ballas, SK, Castro, LD, Hagar, W, Owen, W, Olivieri, N, Smith-Whitley, K, Darbari, D, Wang, W, Vichinsky, E, Balasa, V, Bellevue, R, Cassela, J, Coates, T, Davis, C, Giardina, P, Hilliard, L, Hord, J, Jeng, M, Kirby, M, Kutlar, A, McClain, K, Mentzer, W, Mignaca, R, Pegelow, C, Porter, J, Ramirez, G, Ranalli, M, Rao, S, Scher, C, Shafer, F, Smith, MG, and Thompson, A. "Morbidity and mortality in chronically transfused subjects with Thalassemia and Sickle Cell Disease: A report from the multi-center study of iron overload." American Journal of Hematology 82, no. 4 (2007): 255-265.  Full Text
    • Kihara, AH, de Castro, LM, Moriscot, AS, and Hamassaki, DE. "Prolonged dark adaptation changes connexin expression in the mouse retina." J Neurosci Res 83, no. 7 (May 15, 2006): 1331-1341.  Full Text  Link to Item
    • Edwards, C, Whitfield, K, Sudhakar, S, Pearce, M, Byrd, G, Wood, M, Feliu, M, Leach-Beale, B, DeCastro, L, Whitworth, E, Abrams, M, Jonassaint, J, Harrison, MO, Mathis, M, Scott, L, Johnson, S, Durant, L, Holmes, A, Presnell, K, Bennett, G, Shelby, R, and Robinson, E. "Parental substance abuse, reports of chronic pain and coping in adult patients with sickle cell disease." J Natl Med Assoc 98, no. 3 (March 2006): 420-428.  Link to Item
    • Pells, JJ, Presnell, KE, Edwards, CL, Wood, M, Harrison, MO, DeCastro, L, Johnson, S, Feliu, M, Canada, S, Jonassaint, JC, Barker, C, Leach-Beale, B, Mathis, MJ, Applegate, K, Holmes, A, Byrd, G, and Robinson, E. "Moderate chronic pain, weight and dietary intake in African-American adult patients with sickle cell disease." J Natl Med Assoc 97, no. 12 (December 2005): 1622-1629.  Link to Item
    • Harrison, MO, Edwards, CL, Koenig, HG, Bosworth, HB, Decastro, L, and Wood, M. "Religiosity/spirituality and pain in patients with sickle cell disease." J Nerv Ment Dis 193, no. 4 (April 2005): 250-257.  Link to Item
    • Edwards, CL, Scales, MT, Loughlin, C, Bennett, GG, Harris-Peterson, S, De Castro, LM, Whitworth, E, Abrams, M, Feliu, M, Johnson, S, Wood, M, Harrison, O, and Killough, A. "A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease." Int J Behav Med 12, no. 3 (2005): 171-179. (Review)  Full Text  Link to Item
    • Zennadi, R, Hines, PC, De Castro, LM, Cartron, J-P, Parise, LV, and Telen, MJ. "Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions." Blood 104, no. 12 (December 1, 2004): 3774-3781.  Full Text  Link to Item
    • Zen, Q, Batchvarova, M, Twyman, CA, Eyler, CE, Qiu, H, De Castro, LM, and Telen, MJ. "B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease." Am J Hematol 75, no. 2 (February 2004): 63-72.  Full Text  Link to Item
    • Steinberg, MH, Barton, F, Castro, O, Pegelow, CH, Ballas, SK, Kutlar, A, Orringer, E, Bellevue, R, Olivieri, N, Eckman, J, Varma, M, Ramirez, G, Adler, B, Smith, W, Carlos, T, Ataga, K, DeCastro, L, Bigelow, C, Saunthararajah, Y, Telfer, M, Vichinsky, E, Claster, S, Shurin, S, Bridges, K, Waclawiw, M, Bonds, D, and Terrin, M. "Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia: Risks and Benefits Up to 9 Years of Treatment." Journal of the American Medical Association 289, no. 13 (2003): 1645-1651.  Full Text
    • Castro, LMD, Smitheran, P, and Thomas, P. "Prevalence of hepatitis c in adults with sickle cell disease." Blood 96, no. 11 PART II (2000): 15b-.
    • Rinder, HM, Tracey, JB, Recht, M, DeCastro, L, Rinder, CS, McHugh, C, and Smith, BR. "Differences in platelet α-granule release between normals and immune thrombocytopenic patients and between young and old platelets." Thrombosis and Haemostasis 80, no. 3 (1998): 457-462.
    • De Castro, LM, Kern, ER, De Clercq, E, Ghaffar, A, Mayer, EP, Vogt, PE, and Gangemi, JD. "Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS." Antiviral Res 16, no. 1 (July 1991): 101-114.  Link to Item
    • Tanabe, P, Stevenson, A, DeCastro, L, Drawhorn, L, Lanzkron, S, Molokie, RE, and Artz, N. "Evaluation of a Train-the-Trainer Workshop on Sickle Cell Disease for ED Providers." Journal of Emergency Nursing .  Full Text

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