Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Hematology and Oncology, Medicine, Yale University 1995 - 1998
  • Medical Resident, Medicine, Montefiore Medical Center 1992 - 1995
  • M.D., Universidad Autonoma de Santo Domingo (Dominican Republic) 1986
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Hematology, Medicine 2011 - 2013
  • Assistant Professor of Medicine, Medicine, Hematology, Medicine 2004 - 2010
  • Associate in the Department of Medicine, Medicine, Hematology, Medicine 1998 - 2004
• Research
• 

  Selected Grants

  • Hematopoietic Cell Therapy for Young Adults with Severe Sickle Cell Disease awarded by University of Pittsburgh 2011 - 2014
  • Phase II Study of Propranolol as Anti-Adhesive Therapy in SCD awarded by National Institutes of Health 2009 - 2013
  • PROPRANOLOL AS ANTI-ADHESIVE THERAPY IN SCD awarded by National Institutes of Health 2010 - 2012
  • Relationship of Depression to SCD Severity, Health Care Utilization and QoL awarded by Agency for Healthcare Research and Quality 2008 - 2011
  • Pulmonary Hypertension in SCD awarded by National Institutes of Health 2005 - 2011
  • Factors Involved in B-CAM/LU-Mediated Adhesion awarded by National Institutes of Health 1999 - 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Elmariah, H, Garrett, ME, De Castro, LM, Jonassaint, JC, Ataga, KI, Eckman, JR, Ashley-Koch, AE, and Telen, MJ. "Factors associated with survival in a contemporary adult sickle cell disease cohort." American Journal of Hematology 89, no. 5 (May 2014): 530-535.  Full Text
    • Klings, ES, Machado, RF, Barst, RJ, Morris, CR, Mubarak, KK, Gordeuk, VR, Kato, GJ, Ataga, KI, Gibbs, JS, Castro, O, Rosenzweig, EB, Sood, N, Hsu, L, Wilson, KC, Telen, MJ, Decastro, LM, Krishnamurti, L, Steinberg, MH, Badesch, DB, Gladwin, MT, and American Thoracic Society Ad Hoc Committee on Pulmonary Hypertension of Sickle Cell Disease, . "An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease." American Journal of Respiratory and Critical Care Medicine 189, no. 6 (March 2014): 727-740.  Full Text
    • Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and De Castro, LM. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." The Clinical Journal of Pain 30, no. 3 (March 2014): 266-268.  Full Text
    • Edwards, CL, Killough, A, Wood, M, Doyle, T, Feliu, M, Barker, CS, Uppal, P, DeCastro, L, Wellington, C, Whitfield, KE, O'Garo, K-GN, Morgan, K, Edwards Alesii, LY, Byrd, GS, McCabe, M, Goli, V, Keys, A, Hill, L, Collins-McNeil, J, Trambadia, J, Guinyard, D, Muhammad, M, McDonald, P, Schmechel, DE, and Robinson, E. "Emotional reactions to pain predict psychological distress in adult patients with Sickle Cell Disease (SCD)." International journal of psychiatry in medicine 47, no. 1 (January 2014): 1-16.  Full Text
    • Elmariah, H, Garrett, ME, De Castro, LM, Jonassaint, JC, Ataga, KI, Eckman, JR, Ashley-Koch, AE, and Telen, MJ. "Factors associated with survival in a contemporary adult sickle cell disease cohort." American Journal of Hematology 89, no. 5 (January 1, 2014): 530-535.  Full Text
    • Shah, N, Jonassaint, J, and De Castro, L. "Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART)." Hemoglobin 38, no. 2 (January 2014): 99-103.  Full Text
    • Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and Castro, LMD. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." Clinical Journal of Pain 30, no. 3 (2014): 266-268.  Full Text
    • Tanabe, P, Stevenson, A, DeCastro, L, Drawhorn, L, Lanzkron, S, Molokie, RE, and Artz, N. "Evaluation of a train-the-trainer workshop on sickle cell disease for ED providers." Journal of Emergency Nursing 39, no. 6 (2013): 539-546.  Full Text
    • De Castro, LM, Zennadi, R, Jonassaint, JC, Batchvarova, M, and Telen, MJ. "Effect of propranolol as antiadhesive therapy in sickle cell disease." Clinical and Translational Science 5, no. 6 (December 2012): 437-444.  Full Text
    • Shah, N, Landi, D, Shah, R, Rothman, J, De Castro, LM, and Thornburg, CD. "Complications of implantable venous access devices in patients with sickle cell disease." American Journal of Hematology 87, no. 2 (February 2012): 224-226.  Full Text
    • Ashley-Koch, AE, Okocha, EC, Garrett, ME, Soldano, K, De Castro, LM, Jonassaint, JC, Orringer, EP, Eckman, JR, and Telen, MJ. "MYH9 and APOL1 are both associated with sickle cell disease nephropathy." British Journal of Haematology 155, no. 3 (November 2011): 386-394.  Full Text
    • Royal, CD, Jonassaint, CR, Jonassaint, JC, and De Castro, LM. "Living with sickle cell disease: traversing 'race' and identity." Ethnicity & health 16, no. 4-5 (August 2011): 389-404.  Full Text
    • Jonassaint, CR, Jonassaint, JC, Stanton, MV, De Castro, LM, and Royal, CD. "Clinical and sociodemographic factors predict coping styles among adults with sickle cell disease." Journal of the National Medical Association 102, no. 11 (November 2010): 1045-1049.  Full Text
    • Stanton, MV, Jonassaint, CR, Bartholomew, FB, Edwards, C, Richman, L, DeCastro, L, and Williams, R. "The association of optimism and perceived discrimination with health care utilization in adults with sickle cell disease." Journal of the National Medical Association 102, no. 11 (November 2010): 1056-1063.  Full Text
    • Adam, SS, Telen, MJ, Jonassaint, CR, De Castro, LM, and Jonassaint, JC. "The relationship of opioid analgesia to quality of life in an adult sickle cell population." Health Outcomes Research in Medicine 1, no. 1 (July 1, 2010).  Full Text
    • Steinberg, MH, McCarthy, WF, Castro, O, Ballas, SK, Armstrong, FD, Smith, W, Ataga, K, Swerdlow, P, Kutlar, A, DeCastro, L, Waclawiw, MA, and Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia and MSH Patients' Follow-Up, . "The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up." American Journal of Hematology 85, no. 6 (June 2010): 403-408.  Full Text
    • Vichinsky, EP, Neumayr, LD, Gold, JI, Weiner, MW, Rule, RR, Truran, D, Kasten, J, Eggleston, B, Kesler, K, McMahon, L, Orringer, EP, Harrington, T, Kalinyak, K, De Castro, LM, Kutlar, A, Rutherford, CJ, Johnson, C, Bessman, JD, Jordan, LB, Armstrong, FD, and Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group, . "Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia." Jama 303, no. 18 (May 2010): 1823-1831.  Full Text
    • Brittain, JE, Hulkower, B, Jones, SK, Strayhorn, D, De Castro, L, Telen, MJ, Orringer, EP, Hinderliter, A, and Ataga, KI. "Placenta growth factor in sickle cell disease: association with hemolysis and inflammation." Blood 115, no. 10 (March 2010): 2014-2020.  Full Text
    • Fitzhugh, CD, Lauder, N, Jonassaint, JC, Telen, MJ, Zhao, X, Wright, EC, Gilliam, FR, and De Castro, LM. "Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease." Am J Hematol 85, no. 1 (January 2010): 36-40.  Full Text  Link to Item
    • Edwards, CL, Green, M, Wellington, CC, Muhammad, M, Wood, M, Feliu, M, Edwards, L, Hill, L, Sollers, JJ, Barksdale, C, Robinson, EL, McDougald, CS, Abrams, M, Whitfield, KE, Byrd, G, Hubbard, B, Cola, M, DeCastro, L, and McNeil, J. "Depression, suicidal ideation, and attempts in black patients with sickle cell disease." Journal of the National Medical Association 101, no. 11 (November 2009): 1090-1095.  Full Text
    • Ballas, SK, McCarthy, WF, Guo, N, DeCastro, L, Bellevue, R, Barton, BA, and Waclawiw, MA. "Exposure to hydroxyurea and pregnancy outcomes in patients with sickle cell anemia." Journal of the National Medical Association 101, no. 10 (2009): 1046-1051.
    • Adam, S, Jonassaint, J, Kruger, H, Kail, M, Orringer, EP, Eckman, JR, Ashley-Koch, A, Telen, MJ, and De Castro, LM. "Surgical and obstetric outcomes in adults with sickle cell disease." The American Journal of Medicine 121, no. 10 (October 2008): 916-921.  Full Text
    • Villers, MS, Jamison, MG, De Castro, LM, and James, AH. "Morbidity associated with sickle cell disease in pregnancy." American Journal of Obstetrics and Gynecology 199, no. 2 (August 2008): 125.e1-125.e5.  Full Text
    • Ashley-Koch, AE, Elliott, L, Kail, ME, De Castro, LM, Jonassaint, J, Jackson, TL, Price, J, Ataga, KI, Levesque, MC, Weinberg, JB, Orringer, EP, Collins, A, Vance, JM, and Telen, MJ. "Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease." Blood 111, no. 12 (June 15, 2008): 5721-5726.  Full Text  Link to Item
    • Ataga, KI, Smith, WR, De Castro, LM, Swerdlow, P, Saunthararajah, Y, Castro, O, Vichinsky, E, Kutlar, A, Orringer, EP, Rigdon, GC, Stocker, JW, and ICA-17043-05 Investigators, . "Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia." Blood 111, no. 8 (April 2008): 3991-3997.  Full Text
    • Eyler, CE, Jackson, T, Elliott, LE, De Castro, LM, Jonassaint, J, Ashley-Koch, A, and Telen, MJ. "beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion." Br J Haematol 141, no. 1 (April 2008): 105-108.  Full Text  Link to Item
    • Zennadi, R, De Castro, L, Eyler, C, Xu, K, Ko, M, and Telen, MJ. "Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors." Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine 15, no. 1-2 (February 2008): 23-28.  Full Text
    • De Castro, LM, Jonassaint, JC, Graham, FL, Ashley-Koch, A, and Telen, MJ. "Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes." Am J Hematol 83, no. 1 (January 2008): 19-25.  Full Text  Link to Item
    • Fung, EB, Harmatz, PR, Milet, M, Balasa, V, Ballas, SK, Casella, JF, Hilliard, L, Kutlar, A, McClain, KL, Olivieri, NF, Porter, JB, Vichinsky, EP, Bellevue, R, Coates, T, Darbari, D, Davis, C, DeCastro, L, Giardina, P, Hord, J, Jeng, M, Kirby, M, Mignaca, R, Mentzer, W, Olivieri, N, Owen, W, Pegelow, C, Porter, J, Ramirez, G, Ranalli, M, Rao, S, Scher, C, Shafer, F, Smith, MG, Smith-Whitney, K, Thompson, A, and Wang, W. "Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions." Transfusion 48, no. 9 (2008): 1971-1980.  Full Text
    • Edwards, CL, Raynor, RD, Feliu, M, McDougald, C, Johnson, S, Schmechel, D, Wood, M, Bennett, GG, Saurona, P, Bonner, M, Wellington, C, DeCastro, LM, Whitworth, E, Abrams, M, Logue, P, Edwards, L, Martinez, S, and Whitfield, KE. "Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD)." Neuropsychiatr Dis Treat 3, no. 6 (December 2007): 705-709.  Link to Item
    • Elliott, L, Ashley-Koch, AE, De Castro, L, Jonassaint, J, Price, J, Ataga, KI, Levesque, MC, Brice Weinberg, J, Eckman, JR, Orringer, EP, Vance, JM, and Telen, MJ. "Genetic polymorphisms associated with priapism in sickle cell disease." Br J Haematol 137, no. 3 (May 2007): 262-267.  Full Text  Link to Item
    • Fung, EB, Harmatz, P, Milet, M, Ballas, SK, De Castro, L, Hagar, W, Owen, W, Olivieri, N, Smith-Whitley, K, Darbari, D, Wang, W, Vichinsky, E, and Multi-Center Study of Iron Overload Research Group, . "Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload." American Journal of Hematology 82, no. 4 (April 2007): 255-265.  Full Text
    • Kihara, AH, de Castro, LM, Moriscot, AS, and Hamassaki, DE. "Prolonged dark adaptation changes connexin expression in the mouse retina." Journal of Neuroscience Research 83, no. 7 (May 2006): 1331-1341.  Full Text
    • Edwards, C, Whitfield, K, Sudhakar, S, Pearce, M, Byrd, G, Wood, M, Feliu, M, Leach-Beale, B, DeCastro, L, Whitworth, E, Abrams, M, Jonassaint, J, Harrison, MO, Mathis, M, Scott, L, Johnson, S, Durant, L, Holmes, A, Presnell, K, Bennett, G, Shelby, R, and Robinson, E. "Parental substance abuse, reports of chronic pain and coping in adult patients with sickle cell disease." Journal of the National Medical Association 98, no. 3 (March 2006): 420-428.
    • Pells, JJ, Presnell, KE, Edwards, CL, Wood, M, Harrison, MO, DeCastro, L, Johnson, S, Feliu, M, Canada, S, Jonassaint, JC, Barker, C, Leach-Beale, B, Mathis, MJ, Applegate, K, Holmes, A, Byrd, G, and Robinson, E. "Moderate chronic pain, weight and dietary intake in African-American adult patients with sickle cell disease." Journal of the National Medical Association 97, no. 12 (December 2005): 1622-1629.
    • Harrison, MO, Edwards, CL, Koenig, HG, Bosworth, HB, Decastro, L, and Wood, M. "Religiosity/spirituality and pain in patients with sickle cell disease." J Nerv Ment Dis 193, no. 4 (April 2005): 250-257.  Link to Item
    • Edwards, CL, Scales, MT, Loughlin, C, Bennett, GG, Harris-Peterson, S, De Castro, LM, Whitworth, E, Abrams, M, Feliu, M, Johnson, S, Wood, M, Harrison, O, and Killough, A. "A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease." International Journal of Behavioral Medicine 12, no. 3 (January 2005): 171-179. (Review)  Full Text
    • Zennadi, R, Hines, PC, De Castro, LM, Cartron, J-P, Parise, LV, and Telen, MJ. "Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions." Blood 104, no. 12 (December 2004): 3774-3781.  Full Text
    • Zen, Q, Batchvarova, M, Twyman, CA, Eyler, CE, Qiu, H, De Castro, LM, and Telen, MJ. "B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease." American Journal of Hematology 75, no. 2 (February 2004): 63-72.  Full Text
    • Steinberg, MH, Barton, F, Castro, O, Pegelow, CH, Ballas, SK, Kutlar, A, Orringer, E, Bellevue, R, Olivieri, N, Eckman, J, Varma, M, Ramirez, G, Adler, B, Smith, W, Carlos, T, Ataga, K, DeCastro, L, Bigelow, C, Saunthararajah, Y, Telfer, M, Vichinsky, E, Claster, S, Shurin, S, Bridges, K, Waclawiw, M, Bonds, D, and Terrin, M. "Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia: Risks and Benefits Up to 9 Years of Treatment." Journal of the American Medical Association 289, no. 13 (2003): 1645-1651.  Full Text
    • Castro, LMD, Smitheran, P, and Thomas, P. "Prevalence of hepatitis c in adults with sickle cell disease." Blood 96, no. 11 PART II (2000): 15b-.
    • Rinder, HM, Tracey, JB, Recht, M, DeCastro, L, Rinder, CS, McHugh, C, and Smith, BR. "Differences in platelet α-granule release between normals and immune thrombocytopenic patients and between young and old platelets." Thrombosis and Haemostasis 80, no. 3 (1998): 457-462.
    • De Castro, LM, Kern, ER, De Clercq, E, Ghaffar, A, Mayer, EP, Vogt, PE, and Gangemi, JD. "Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS." Antiviral Research 16, no. 1 (July 1991): 101-114.  Full Text
    • Tanabe, P, Stevenson, A, DeCastro, L, Drawhorn, L, Lanzkron, S, Molokie, RE, and Artz, N. "Evaluation of a Train-the-Trainer Workshop on Sickle Cell Disease for ED Providers." Journal of Emergency Nursing .  Full Text

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