Deepak Kumar

Journal Article Int J Environ Res Public Health · December 10, 2024 As new artificial intelligence (AI) tools are being developed and as AI continues to revolutionize healthcare, its potential to advance health equity is increasingly recognized. The 2024 Research Centers in Minority Institutions (RCMI) Consortium National ... Full text Link to item Cite

Ethyltoluenes Regulate Inflammatory and Cell Fibrosis Signaling in the Liver Cell Model.

Journal Article Toxics · November 27, 2024 Crude oil naphtha fraction C9 alkylbenzenes consist of trimethylbenzenes, ethyltoluenes, cumene, and n-propylbenzene. The major fraction of C9 alkylbenzenes is ethyltoluenes (ETs) consisting of three isomers: 2-ethyltoluene (2-ET), 3-ethyltoluene (3-ET), a ... Full text Link to item Cite

Clemastine and hyperthermia enhance sensitization of osteosarcoma cells for apoptosis.

Journal Article Mol Cell Oncol · 2024 Clemastine is an antagonist of histamine H1 receptor may provide benefits in the treatment of osteosarcoma (OS). In the current study, we used hyperthermia approach to sensitize OS cells to clemastine-mediated cell death. Osteosarcoma U-2 OS and Saos-2 cel ... Full text Link to item Cite

Cyanotoxins Increase Cytotoxicity and Promote Nonalcoholic Fatty Liver Disease Progression by Enhancing Cell Steatosis.

Journal Article Toxins (Basel) · June 25, 2023 Freshwater prokaryotic cyanobacteria within harmful algal blooms produce cyanotoxins which are considered major pollutants in the aquatic system. Direct exposure to cyanotoxins through inhalation, skin contact, or ingestion of contaminated drinking water c ... Full text Link to item Cite

MicroRNA-483-5p Inhibits Hepatocellular Carcinoma Cell Proliferation, Cell Steatosis, and Fibrosis by Targeting PPARα and TIMP2.

Journal Article Cancers (Basel) · March 10, 2023 MicroRNAs (miRNAs) are small non-coding RNA molecules that bind with the 3' untranslated regions (UTRs) of genes to regulate expression. Downregulation of miR-483-5p (miR-483) is associated with the progression of hepatocellular carcinoma (HCC). However, t ... Full text Link to item Cite

Strategic Team Science Promotes Collaboration and Practice-Based Research at the Research Centers in Minority Institutions.

Journal Article Int J Environ Res Public Health · March 9, 2023 BACKGROUND: This paper reports on the implementation and evaluation of a strategy to promote collaborations and team science among investigators at the Research Centers in Minority Institutions (RCMI). The strategy presented in this paper was a hands-on wo ... Full text Link to item Cite

Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT/mTOR pathways.

Journal Article Environ Toxicol · March 2023 Cadmium (Cd) is an environmental pollutant that increases hepatotoxicity and the risk of liver diseases. In the current study, we investigated the effect of a physiologically relevant, low concentration of Cd on the regulation of liver cancer cell prolifer ... Full text Link to item Cite

Per- and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells.

Journal Article Environ Toxicol · January 2023 Per- and polyfluoroalkyl substances (PFAS), which include perfluorooctanoic acid (PFOA), heptafluorobutyric acid (HFBA), and perfluorotetradecanoic acid (PFTA), are commonly occurring organic pollutants. Exposure to PFAS affects the immune system, thyroid ... Full text Link to item Cite

MiR-182-5p Modulates Prostate Cancer Aggressive Phenotypes by Targeting EMT Associated Pathways.

Journal Article Biomolecules · January 22, 2022 Prostate cancer (PCa) is a clinically heterogeneous disease, where deregulation of epigenetic events, such as miRNA expression alterations, are determinants for its development and progression. MiR-182-5p, a member of the miR-183 family, when overexpressed ... Full text Link to item Cite

Carnitine Palmitoyltransferase 1 Regulates Prostate Cancer Growth under Hypoxia.

Journal Article Cancers (Basel) · December 15, 2021 Hypoxia and hypoxia-related biomarkers are the major determinants of prostate cancer (PCa) aggressiveness. Therefore, a better understanding of molecular players involved in PCa cell survival under hypoxia could offer novel therapeutic targets. We previous ... Full text Link to item Cite

Trends in COVID-19 Health Disparities in North Carolina: Preparing the Field for Long-Haul Patients.

Journal Article Healthcare (Basel) · December 8, 2021 Long-term coronavirus disease 2019 (long-COVID) refers to persistent symptoms of SARS-CoV-2 (COVID-19) lingering beyond four weeks of initial infection. Approximately 30% of COVID-19 survivors develop prolonged symptoms. Communities of color are disproport ... Full text Link to item Cite

Knockdown of microRNA-214-3p Promotes Tumor Growth and Epithelial-Mesenchymal Transition in Prostate Cancer.

Journal Article Cancers (Basel) · November 23, 2021 Abnormal expression of microRNA miR-214-3p (miR-214) is associated with multiple cancers. In this study, we assessed the effects of CRISPR/Cas9 mediated miR-214 depletion in prostate cancer (PCa) cells and the underlying mechanisms. Knockdown of miR-214 pr ... Full text Link to item Cite

KCNQ1OT1: An Oncogenic Long Noncoding RNA.

Journal Article Biomolecules · October 29, 2021 Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease. KCNQ1 Oppos ... Full text Link to item Cite

Challenges and Strategies of Successful Mentoring: The Perspective of LEADS Scholars and Mentors from Minority Serving Institutions.

Journal Article Int J Environ Res Public Health · June 7, 2021 Mentoring continues to be a salient conversation in academia among junior and senior faculty and administrators. Mentors provide guidance and structure to junior faculty so that they can meet their academic and professional goals. Mentors also convey skill ... Full text Link to item Cite

Strengthening and Sustaining Inter-Institutional Research Collaborations and Partnerships.

Journal Article Int J Environ Res Public Health · March 8, 2021 Inter-institutional collaborations and partnerships play fundamental roles in developing and diversifying the basic biomedical, behavioral, and clinical research enterprise at resource-limited, minority-serving institutions. In conjunction with the Researc ... Full text Link to item Cite

COVID-19 vaccine hesitancy in underserved communities of North Carolina.

Journal Article PloS one · January 2021 BackgroundIn the United States, underserved communities including Blacks and Latinx are disproportionately affected by COVID-19. This study sought to estimate the prevalence of COVID-19 vaccine hesitancy, describe attitudes related to vaccination, ... Full text Cite

Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases.

Journal Article J Toxicol · 2021 Cadmium (Cd) is a toxic pollutant that is associated with several severe human diseases. Cd can be easily absorbed in significant quantities from air contamination/industrial pollution, cigarette smoke, food, and water and primarily affects the liver, kidn ... Full text Link to item Cite

Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma.

Journal Article Int J Hepatol · 2021 Autophagy is a conserved catabolic process that eliminates dysfunctional cytosolic biomolecules through vacuole-mediated sequestration and lysosomal degradation. Although the molecular mechanisms that regulate autophagy are not fully understood, recent wor ... Full text Link to item Cite

Diseases with health disparities as drivers of COVID-19 outcome.

Journal Article J Cell Mol Med · October 2020 The COVID-19 pandemic has forced our society to come face to face with complex issues that were once theoretical but are now being played out in real time. As data from the pandemic accumulates, it is clear that COVID-19 is impacting some parts of society ... Full text Link to item Cite

The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells.

Journal Article Cells · August 29, 2020 Exosomes are membrane-bound extracellular vesicles (EVs) that transport bioactive materials between cells and organs. The cargo delivered by exosomes can alter a wide range of cellular responses in recipient cells and play an important pathophysiological r ... Full text Link to item Cite

TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation.

Journal Article Cell Death Dis · March 9, 2020 Tumor necrosis factor-α-induced protein 8 (TNFAIP8) expression has been linked to tumor progression in various cancer types, but the detailed mechanisms of TNFAIP8 are not fully elucidated. Here we define the role of TNFAIP8 in early events associated with ... Full text Link to item Cite

Emerging role of microRNA 628-5p as a novel biomarker for cancer and other diseases.

Journal Article Tumour Biol · October 2019 MicroRNAs are a family of small, single-stranded RNAs that have key roles in regulating multiple signaling pathways within a cell. Studies have implicated aberrant expression of microRNAs in the development and progression of several pathologies including ... Full text Link to item Cite

The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells.

Journal Article Mol Cancer Res · September 2019 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited and, very often, ineffective medical and surgical therapeutic options. The treatment of patients with advanced unresectable PDAC is restricted to systemic chemotherapy, a t ... Full text Link to item Cite

MicroRNA-214 targets PTK6 to inhibit tumorigenic potential and increase drug sensitivity of prostate cancer cells.

Journal Article Sci Rep · July 5, 2019 Prostate cancer is the most commonly diagnosed cancer in men with African American men disproportionally suffering from the burden of this disease. Biomarkers that could discriminate indolent from aggressive and drug resistance disease are lacking. MicroRN ... Full text Link to item Cite

Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8).

Journal Article Cells · December 24, 2018 Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8) is a founding member of the TIPE family, which also includes TNFAIP8-like 1 (TIPE1), TNFAIP8-like 2 (TIPE2), and TNFAIP8-like 3 (TIPE3) proteins. Expression of TNFAIP8 is strongly associated with th ... Full text Link to item Cite