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Delbert Raye Wigfall

Professor Emeritus of Pediatrics
Pediatrics, Nephrology
2301 Erwin Rd, Durham, NC 27710
2301 Erwin Rd, Durham, NC 27710

Selected Publications


Seeking justice, equity, diversity and inclusion in pediatric nephrology

Journal Article Frontiers in Pediatrics · December 12, 2022 Inequity, racism, and health care disparities negatively impact the well-being of children with kidney disease. This review defines social determinants of health and describes how they impact pediatric nephrology care; outlines the specific impact of syste ... Full text Cite

Tailored use of belatacept in adolescent kidney transplantation.

Journal Article Am J Transplant · March 2020 Adolescent transplant recipients are at risk for nonadherence, development of de novo donor-specific antibody (dnDSA), and allograft loss. Belatacept, a selective T cell costimulatory blocker, is associated with reduced dnDSA, improved renal function, and ... Full text Link to item Cite

Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study.

Journal Article Pediatr Nephrol · March 2019 The original version of this article unfortunately contained a mistake. The subtitle "A Midwest Pediatric Nephrology Consortium (MWPNC) study" was missing. The correct title including subtitle is given above. ... Full text Link to item Cite

Essentials of Nephrology

Chapter · January 1, 2019 The basic functions of the kidney are to maintain fluid and electrolyte homeostasis and metabolism. Renal disease requires the practitioner to be vigilant about fluid homeostasis, acid-base balance, electrolyte management, choice of anesthetics, and potent ... Full text Cite

Psychosocial Assessment of Candidates for Transplantation (PACT) Score Identifies High Risk Patients in Pediatric Renal Transplantation.

Journal Article Front Pediatr · 2019 Background: Currently, there is no standardized approach for determining psychosocial readiness in pediatric transplantation. We examined the utility of the Psychosocial Assessment of Candidates for Transplantation (PACT) to identify pediatric kidney trans ... Full text Open Access Link to item Cite

Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings.

Journal Article Pediatr Nephrol · October 2018 BACKGROUND AND OBJECTIVES: Steroid-resistant nephrotic syndrome (SRNS) due to focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is a leading cause of end-stage kidney disease in children. Recurrence of primary disease following tra ... Full text Link to item Cite

Essentials of Nephrology

Chapter · January 1, 2018 The basic functions of the kidney are to maintain fluid and electrolyte homeostasis and metabolism. Renal disease requires the practitioner to be vigilant about fluid homeostasis, acid-base balance, electrolyte management, choice of anesthetics, and potent ... Full text Cite

Neutropenic enterocolitis (typhlitis) in a pediatric renal transplant patient. A case report and review of the literature.

Journal Article Pediatr Transplant · September 2017 NE (typhlitis) is a potentially life-threatening disease process characterized by bowel wall edema, ulceration, and hemorrhage in an immunosuppressed patient. We report a 15-year-old boy status post deceased donor renal transplantation who presented with f ... Full text Link to item Cite

Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.

Journal Article Pediatr Nephrol · February 2016 BACKGROUND: Primary vesicoureteral reflux (PVUR) is the most common malformation of the kidney and urinary tract, and reflux nephropathy is a major cause of chronic kidney disease in children. Recently, we reported mutations in the tenascin XB gene (TNXB) ... Full text Link to item Cite

Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation.

Journal Article Clin Kidney J · October 2015 BACKGROUND: Mutations in podocin (NPHS2) are the most common cause of childhood onset autosomal recessive steroid-resistant nephrotic syndrome (SRNS). The disease is characterized by early-onset proteinuria, resistance to immunosuppressive therapy and rapi ... Full text Open Access Link to item Cite

HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.

Journal Article J Am Soc Nephrol · July 2015 Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases of nephrotic syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome arra ... Full text Link to item Cite

Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis.

Journal Article J Urol · March 2015 PURPOSE: Controversy exists regarding the use of continuous antibiotic prophylaxis vs observation in the management of children with vesicoureteral reflux. The reported effectiveness of continuous antibiotic prophylaxis in children with reflux varies widel ... Full text Link to item Cite

Community and treatment engagement for depressed African American youth: the AAKOMA FLOA pilot.

Journal Article J Clin Psychol Med Settings · March 2012 This manuscript focuses on the recruitment efforts and pilot testing of a culturally tailored motivational interviewing intervention associated with the AAKOMA Project, a 2-phase treatment engagement intervention trial for depressed African American adoles ... Full text Link to item Cite

Essentials of Nephrology

Journal Article · December 1, 2009 Full text Cite

Management patterns of childhood-onset nephrotic syndrome.

Journal Article Pediatr Nephrol · November 2009 As an initial effort to identify opportunities to improve the management of children with nephrotic syndrome, the goal of this study was to assess the present-day management of children with primary nephrotic syndrome. A web-based survey was designed to as ... Full text Link to item Cite

Management of childhood onset nephrotic syndrome.

Journal Article Pediatrics · August 2009 The therapeutic approach to childhood nephrotic syndrome is based on a series of studies that began with an international collaborative effort sponsored by the International Study of Kidney Disease in Children in 1967. The characteristics of children prese ... Full text Link to item Cite

Essentials of nephrology

Chapter · December 1, 2008 Full text Cite

Enalapril and hydroxyurea therapy for children with sickle nephropathy.

Journal Article Pediatr Blood Cancer · December 2005 Featured Publication Proteinuria in children with sickle cell anemia (SCA) is an early sign of sickle nephropathy, and portends the development of nephrotic syndrome and chronic renal failure. Enalapril has been shown to reduce proteinuria in adult patients with SCA, but the p ... Full text Link to item Cite

Seeking justice, equity, diversity and inclusion in pediatric nephrology

Journal Article Frontiers in Pediatrics · December 12, 2022 Inequity, racism, and health care disparities negatively impact the well-being of children with kidney disease. This review defines social determinants of health and describes how they impact pediatric nephrology care; outlines the specific impact of syste ... Full text Cite

Tailored use of belatacept in adolescent kidney transplantation.

Journal Article Am J Transplant · March 2020 Adolescent transplant recipients are at risk for nonadherence, development of de novo donor-specific antibody (dnDSA), and allograft loss. Belatacept, a selective T cell costimulatory blocker, is associated with reduced dnDSA, improved renal function, and ... Full text Link to item Cite

Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study.

Journal Article Pediatr Nephrol · March 2019 The original version of this article unfortunately contained a mistake. The subtitle "A Midwest Pediatric Nephrology Consortium (MWPNC) study" was missing. The correct title including subtitle is given above. ... Full text Link to item Cite

Essentials of Nephrology

Chapter · January 1, 2019 The basic functions of the kidney are to maintain fluid and electrolyte homeostasis and metabolism. Renal disease requires the practitioner to be vigilant about fluid homeostasis, acid-base balance, electrolyte management, choice of anesthetics, and potent ... Full text Cite

Psychosocial Assessment of Candidates for Transplantation (PACT) Score Identifies High Risk Patients in Pediatric Renal Transplantation.

Journal Article Front Pediatr · 2019 Background: Currently, there is no standardized approach for determining psychosocial readiness in pediatric transplantation. We examined the utility of the Psychosocial Assessment of Candidates for Transplantation (PACT) to identify pediatric kidney trans ... Full text Open Access Link to item Cite

Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings.

Journal Article Pediatr Nephrol · October 2018 BACKGROUND AND OBJECTIVES: Steroid-resistant nephrotic syndrome (SRNS) due to focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is a leading cause of end-stage kidney disease in children. Recurrence of primary disease following tra ... Full text Link to item Cite

Essentials of Nephrology

Chapter · January 1, 2018 The basic functions of the kidney are to maintain fluid and electrolyte homeostasis and metabolism. Renal disease requires the practitioner to be vigilant about fluid homeostasis, acid-base balance, electrolyte management, choice of anesthetics, and potent ... Full text Cite

Neutropenic enterocolitis (typhlitis) in a pediatric renal transplant patient. A case report and review of the literature.

Journal Article Pediatr Transplant · September 2017 NE (typhlitis) is a potentially life-threatening disease process characterized by bowel wall edema, ulceration, and hemorrhage in an immunosuppressed patient. We report a 15-year-old boy status post deceased donor renal transplantation who presented with f ... Full text Link to item Cite

Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.

Journal Article Pediatr Nephrol · February 2016 BACKGROUND: Primary vesicoureteral reflux (PVUR) is the most common malformation of the kidney and urinary tract, and reflux nephropathy is a major cause of chronic kidney disease in children. Recently, we reported mutations in the tenascin XB gene (TNXB) ... Full text Link to item Cite

Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation.

Journal Article Clin Kidney J · October 2015 BACKGROUND: Mutations in podocin (NPHS2) are the most common cause of childhood onset autosomal recessive steroid-resistant nephrotic syndrome (SRNS). The disease is characterized by early-onset proteinuria, resistance to immunosuppressive therapy and rapi ... Full text Open Access Link to item Cite

HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.

Journal Article J Am Soc Nephrol · July 2015 Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases of nephrotic syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome arra ... Full text Link to item Cite

Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis.

Journal Article J Urol · March 2015 PURPOSE: Controversy exists regarding the use of continuous antibiotic prophylaxis vs observation in the management of children with vesicoureteral reflux. The reported effectiveness of continuous antibiotic prophylaxis in children with reflux varies widel ... Full text Link to item Cite

Community and treatment engagement for depressed African American youth: the AAKOMA FLOA pilot.

Journal Article J Clin Psychol Med Settings · March 2012 This manuscript focuses on the recruitment efforts and pilot testing of a culturally tailored motivational interviewing intervention associated with the AAKOMA Project, a 2-phase treatment engagement intervention trial for depressed African American adoles ... Full text Link to item Cite

Essentials of Nephrology

Journal Article · December 1, 2009 Full text Cite

Management patterns of childhood-onset nephrotic syndrome.

Journal Article Pediatr Nephrol · November 2009 As an initial effort to identify opportunities to improve the management of children with nephrotic syndrome, the goal of this study was to assess the present-day management of children with primary nephrotic syndrome. A web-based survey was designed to as ... Full text Link to item Cite

Management of childhood onset nephrotic syndrome.

Journal Article Pediatrics · August 2009 The therapeutic approach to childhood nephrotic syndrome is based on a series of studies that began with an international collaborative effort sponsored by the International Study of Kidney Disease in Children in 1967. The characteristics of children prese ... Full text Link to item Cite

Essentials of nephrology

Chapter · December 1, 2008 Full text Cite

Enalapril and hydroxyurea therapy for children with sickle nephropathy.

Journal Article Pediatr Blood Cancer · December 2005 Featured Publication Proteinuria in children with sickle cell anemia (SCA) is an early sign of sickle nephropathy, and portends the development of nephrotic syndrome and chronic renal failure. Enalapril has been shown to reduce proteinuria in adult patients with SCA, but the p ... Full text Link to item Cite

Genitourinary complications of sickle cell disease.

Journal Article J Urol · September 2001 Featured Publication PURPOSE: In the last half century the molecular biology, pathophysiology and natural history of sickle cell disease have been well defined. Sickle cell disease causes microvascular occlusion, which is manifested in most organ systems. The genitourinary tra ... Link to item Cite

Prevalence and clinical correlates of glomerulopathy in children with sickle cell disease.

Journal Article J Pediatr · June 2000 Featured Publication OBJECTIVES: Glomerular disease and renal failure cause substantial morbidity for patients with sickle cell disease (SCD). Proteinuria is an early manifestation of sickle nephropathy, but the prevalence of proteinuria and its clinical correlations in childr ... Link to item Cite

Appearance of immune complex glomerulonephritis following the onset of type I diabetes mellitus in a child.

Journal Article Am J Kidney Dis · November 1997 Renal disease is a frequent late complication of type I diabetes mellitus, occurring almost entirely in adult patients. Typical diabetic nephropathy is characterized by proteinuria, and by the histological lesions of mesangial expansion and basement membra ... Full text Link to item Cite

Non-cytotoxic effects of complement on vascular endothelium.

Journal Article JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · September 1, 1997 Link to item Cite

Identification of selective immunoglobulin a deficiency by renal biopsy.

Journal Article Am J Kidney Dis · September 1995 We report three cases of selective immunoglobulin A (IgA) deficiency in which lack of direct immunofluorescent staining for IgA on renal biopsy specimens contributed to the diagnosis. In two patients, one with systemic lupus erythematosus and the other hav ... Full text Link to item Cite

PREDICTORS OF GLOMERULAR-DISEASE IN CHILDREN AND ADULTS WITH SICKLE-CELL-ANEMIA

Journal Article JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · September 1, 1994 Link to item Cite

Interleukin-2 receptor expression in peripheral blood lymphocytes from systemic lupus erythematosus patients: relationship to clinical activity.

Journal Article Clin Immunol Immunopathol · June 1988 Deficient interleukin-2 (IL-2) production and other T-cell dysfunctions have been demonstrated in active systemic lupus erythematosus (SLE). The generation of IL-2 receptors is known to be important to the growth and differentiation of T and B lymphocytes. ... Full text Link to item Cite