Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Internal Medicine, Icahn School of Medicine at Mount Sinai 2003 - 2005
  • Intern, Internal Medicine, Icahn School of Medicine at Mount Sinai 2002 - 2003
  • M.D., Thomas Jefferson University 2002
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2015 - 2020
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2012 - 2015
• Research
• 

  Selected Grants

  • Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heart awarded by National Institutes of Health 2021 - 2025
  • Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration awarded by National Aeronautics and Space Administration 2016 - 2022
  • TREK-1 in fibroblast differentiation and cardiac fibrosis development awarded by National Institutes of Health 2015 - 2020
  • TREK-1 in fibroblast differentiation and cardiac fibrosis development awarded by  American Heart Association 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Bishawi, M., Lee, F. H., Abraham, D. M., Glass, C., Blocker, S. J., Cox, D. J., … Bowles, D. E. (2022). Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure. Iscience, 25(4), 104086. https://doi.org/10.1016/j.isci.2022.104086
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    • Lekavich, C. L., Abraham, D., Fudim, M., Green, C., Mentz, R. J., Harshaw-Ellis, K., … Kraus, W. E. (2021). Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends. J Card Fail, 27(9), 942–948. https://doi.org/10.1016/j.cardfail.2021.03.013
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    • Lee, C.-L., Lee, J. W., Daniel, A. R., Holbrook, M., Hasapis, S., Wright, A. O., … Kirsch, D. G. (2021). Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation. Radiother Oncol, 157, 155–162. https://doi.org/10.1016/j.radonc.2021.01.023
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    • Huffman, K. M., Andonian, B. J., Abraham, D. M., Bareja, A., Lee, D. E., Katz, L. H., … White, J. P. (2021). Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis. J Appl Physiol (1985), 130(3), 853–864. https://doi.org/10.1152/japplphysiol.00576.2020
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    • Sparks, M. A., Rianto, F., Diaz, E., Revoori, R., Hoang, T., Bouknight, L., … Coffman, T. M. (2021). Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy. Hypertension, 77(2), 393–404. https://doi.org/10.1161/HYPERTENSIONAHA.119.14079
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    • Davidson, M. T., Grimsrud, P. A., Lai, L., Draper, J. A., Fisher-Wellman, K. H., Narowski, T. M., … Muoio, D. M. (2020). Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure. Circ Res, 127(8), 1094–1108. https://doi.org/10.1161/CIRCRESAHA.120.317293
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    • Slosky, L. M., Bai, Y., Toth, K., Ray, C., Rochelle, L. K., Badea, A., … Caron, M. G. (2020). β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell, 181(6), 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053
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    • Edmonston, D. L., Parikh, K. S., Rajagopal, S., Shaw, L. K., Abraham, D., Grabner, A., … Wolf, M. (2020). Pulmonary Hypertension Subtypes and Mortality in CKD. Am J Kidney Dis, 75(5), 713–724. https://doi.org/10.1053/j.ajkd.2019.08.027
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    • Li, Y., Song, D., Mao, L., Abraham, D. M., & Bursac, N. (2020). Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure. Biomaterials, 236, 119824. https://doi.org/10.1016/j.biomaterials.2020.119824
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    • Duan, W., Hicks, J., Makara, M. A., Ilkayeva, O., & Abraham, D. M. (2020). TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction. Am J Physiol Heart Circ Physiol, 318(3), H566–H580. https://doi.org/10.1152/ajpheart.00739.2018
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    • Han, S.-O., Haynes, A. C., Li, S., Abraham, D. M., Kishnani, P. S., Steet, R., & Koeberl, D. D. (2020). Evaluation of antihypertensive drugs in combination with enzyme replacement therapy in mice with Pompe disease. Mol Genet Metab, 129(2), 73–79. https://doi.org/10.1016/j.ymgme.2019.10.005
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    • Yu, S.-W., Jean-Charles, P.-Y., Abraham, D. M., Kaur, S., Gareri, C., Mao, L., … Shenoy, S. K. (2019). The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling. J Biol Chem, 294(7), 2500–2518. https://doi.org/10.1074/jbc.RA118.004926
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    • Abraham, D. M., Lee, T. E., Watson, L. J., Mao, L., Chandok, G., Wang, H.-G., … Rockman, H. A. (2018). The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. J Clin Invest, 128(11), 4843–4855. https://doi.org/10.1172/JCI95945
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    • Hershberger, K. A., Abraham, D. M., Liu, J., Locasale, J. W., Grimsrud, P. A., & Hirschey, M. D. (2018). Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. The Journal of Biological Chemistry, 293(27), 10630–10645. https://doi.org/10.1074/jbc.ra118.002187
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    • Toth, K., Slosky, L. M., Pack, T. F., Urs, N. M., Boone, P., Mao, L., … Barak, L. S. (2018). Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2. Synapse, 72(1). https://doi.org/10.1002/syn.22012
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    • Hershberger, K. A., Abraham, D. M., Martin, A. S., Mao, L., Liu, J., Gu, H., … Hirschey, M. D. (2017). Sirtuin 5 is required for mouse survival in response to cardiac pressure overload. J Biol Chem, 292(48), 19767–19781. https://doi.org/10.1074/jbc.M117.809897
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    • Jean-Charles, P.-Y., Yu, S.-W., Abraham, D., Kommaddi, R. P., Mao, L., Strachan, R. T., … Shenoy, S. K. (2017). Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. Jci Insight, 2(17). https://doi.org/10.1172/jci.insight.95998
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    • Martin, A. S., Abraham, D. M., Hershberger, K. A., Bhatt, D. P., Mao, L., Cui, H., … Hirschey, M. D. (2017). Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. Jci Insight, 2(14). https://doi.org/10.1172/jci.insight.93885
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    • Abraham, D. M., Davis, R. T., Warren, C. M., Mao, L., Wolska, B. M., Solaro, R. J., & Rockman, H. A. (2016). β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility. Proc Natl Acad Sci U S A, 113(50), 14426–14431. https://doi.org/10.1073/pnas.1609308113
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    • Abraham, D., & Mao, L. (2015). Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice. J Vis Exp, (103). https://doi.org/10.3791/52942
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    • Pironti, G., Strachan, R. T., Abraham, D., Mon-Wei Yu, S., Chen, M., Chen, W., … Rockman, H. A. (2015). Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. Circulation, 131(24), 2120–2130. https://doi.org/10.1161/CIRCULATIONAHA.115.015687
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    • Abraham, D. M., & Marchuk, D. A. (2014). Inhibition of the cardiomyocyte-specific troponin I-interacting kinase limits oxidative stress, injury, and adverse remodeling due to ischemic heart disease. Circ Res, 114(6), 938–940. https://doi.org/10.1161/CIRCRESAHA.113.303238
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    • Abraham, D. M., & Wolf, M. J. (2013). Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction. Plos One, 8(10), e77785. https://doi.org/10.1371/journal.pone.0077785
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    • Kim, K.-S., Abraham, D., Williams, B., Violin, J. D., Mao, L., & Rockman, H. A. (2012). β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. Am J Physiol Heart Circ Physiol, 303(8), H1001–H1010. https://doi.org/10.1152/ajpheart.00475.2012
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    • Casad, M. E., Abraham, D., Kim, I.-M., Frangakis, S., Dong, B., Lin, N., … Rockman, H. A. (2011). Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster. Genetics, 189(3), 861–870. https://doi.org/10.1534/genetics.111.131482
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    • Lin, N., Badie, N., Yu, L., Abraham, D., Cheng, H., Bursac, N., … Wolf, M. J. (2011). A method to measure myocardial calcium handling in adult Drosophila. Circ Res, 108(11), 1306–1315. https://doi.org/10.1161/CIRCRESAHA.110.238105
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    • Shimbo, D., Chaplin, W., Kuruvilla, S., Wasson, L. T., Abraham, D., & Burg, M. M. (2009). Hostility and platelet reactivity in individuals without a history of cardiovascular disease events. Psychosom Med, 71(7), 741–747. https://doi.org/10.1097/PSY.0b013e3181ad18b6
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    • Shimbo, D., Pickering, T. G., Spruill, T. M., Abraham, D., Schwartz, J. E., & Gerin, W. (2007). Relative utility of home, ambulatory, and office blood pressures in the prediction of end-organ damage. Am J Hypertens, 20(5), 476–482. https://doi.org/10.1016/j.amjhyper.2006.12.011
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    • Shimbo, D., Chaplin, W., Akinola, O., Harris, A., Abraham, D., Homma, S., & Gerin, W. (2007). Effect of anger provocation on endothelium-dependent and -independent vasodilation. Am J Cardiol, 99(6), 860–863. https://doi.org/10.1016/j.amjcard.2006.10.051
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    • Gerin, W., Schwartz, J. E., Devereux, R. B., Goyal, T., Shimbo, D., Ogedegbe, G., … Pickering, T. G. (2006). Superiority of ambulatory to physician blood pressure is not an artifact of differential measurement reliability. Blood Press Monit, 11(6), 297–301. https://doi.org/10.1097/01.mbp.0000218005.73204.b7
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  • Conference Papers

    • Torok, R. D., Abraham, D. M., Gareri, C., Mao, L., & Rockman, H. A. (2016). TWIK-Related Acid-Sensitive K+ Channels Affect the Development of Aortic Root Aneurysms in Mice. In Circulation (Vol. 134). Pentagon City, VA: LIPPINCOTT WILLIAMS & WILKINS.
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    • Abraham, D. M., Lee, T. E., Watson, L. J., Mao, L., Chandok, G., Wolf, M. J., & Rockman, H. A. (2014). TREK-1 Modulates Fibrosis & Diastolic Dysfunction Through Activation of Stress-Activated Kinases. In Circulation (Vol. 130). LIPPINCOTT WILLIAMS & WILKINS.
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