Derek Wilson Cain
Associate Professor in Medicine
My research focuses on the interactions of T cells and B cells during infection or following vaccination. I am particularly interested in the inter- and intracellular events that take place within germinal centers, the anatomic site of antibody evolution during an immune response.
Current Appointments & Affiliations
- Associate Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2021
- Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2016
Contact Information
- 2 Genome Ct - Rm 4083 MSRBII, Durham, NC 27710
- Box 103020, Durham, NC 27710
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(919) 681-8193
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Visit the DHVI Flow Cytometry Facility website
- Background
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Education, Training, & Certifications
- Ph.D., Duke University 2010
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Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2021
- Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2016 - 2020
- Consulting Associate in the School of Nursing, School of Nursing, Duke University 2014 - 2016
- Expertise
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Subject Headings
- Research
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Selected Grants
- SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens awarded by National Institutes of Health 2022 - 2027
- Natural killer cell regulation of the germinal center HIV neutralizing antibody response awarded by The Children's Mercy Hospital 2019 - 2023
- CIVICS Component A - Option 3 awarded by National Institutes of Health 2019 - 2023
- Targeting natural killer cells to enhance HIV vaccine responses awarded by Cincinnati Children's Hospital Medical Center 2019 - 2023
- Neonatal Immunity to novel TF SHIVs awarded by National Institutes of Health 2018 - 2023
- Langorin-eOD project awarded by Vaccine Research Institute 2019 - 2020
- Natural killer cell regulation of the germinal center HIV neutralizing antibody response awarded by The Children's Mercy Hospital 2019
- P186 Research Analysis awarded by Tulane University 2018
- Eliciting B cells to produce anti-HIV gp41 MPER-specific neutralizing antibodies, Identifying Critical Stages in Vaccine Indcued HIV-1 Immunity - Project 4 awarded by Dana-Farber Cancer Institute 2010 - 2015
- B-cell Tolerance and Humoral Immunity to HIV-1 awarded by National Institutes of Health 2009 - 2014
- Analysis of the Murine Antibody Repertoire awarded by National Institutes of Health 2009 - 2011
- Analysis of the Murine Antibody Repertoire awarded by National Institutes of Health 1989 - 2008
- The Role of Complement in Autoimmunity awarded by National Institutes of Health 2001 - 2007
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hora, Bhavna, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, et al. “Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies.” Cell Rep 42, no. 3 (March 28, 2023): 112255. https://doi.org/10.1016/j.celrep.2023.112255.Full Text Link to Item
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Bibollet-Ruche, Frederic, Ronnie M. Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, et al. “A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.” Mbio 14, no. 1 (February 28, 2023): e0337022. https://doi.org/10.1128/mbio.03370-22.Full Text Link to Item
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Li, Dapeng, David R. Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, et al. “Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.” Nat Commun 13, no. 1 (October 23, 2022): 6309. https://doi.org/10.1038/s41467-022-33985-4.Full Text Open Access Copy Link to Item
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Saunders, Kevin O., Robert J. Edwards, Kedamawit Tilahun, Kartik Manne, Xiaozhi Lu, Derek W. Cain, Kevin Wiehe, et al. “Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.” Sci Transl Med 14, no. 661 (September 7, 2022): eabo5598. https://doi.org/10.1126/scitranslmed.abo5598.Full Text Open Access Copy Link to Item
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Li, Dapeng, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, et al. “Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.” Commun Biol 5, no. 1 (March 28, 2022): 271. https://doi.org/10.1038/s42003-022-03183-5.Full Text Link to Item
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Mu, Zekun, Kevin Wiehe, Kevin O. Saunders, Rory Henderson, Derek W. Cain, Robert Parks, Diana Martik, et al. “mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.” Cell Rep 38, no. 11 (March 15, 2022): 110514. https://doi.org/10.1016/j.celrep.2022.110514.Full Text Link to Item
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Mu, Zekun, Barton F. Haynes, and Derek W. Cain. “Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination.” Curr Opin Virol 51 (December 2021): 172–78. https://doi.org/10.1016/j.coviro.2021.09.015.Full Text Link to Item
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Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.Full Text Open Access Copy Link to Item
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Fries, Chelsea N., Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, et al. “HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.” Sci Rep 11, no. 1 (July 14, 2021): 14494. https://doi.org/10.1038/s41598-021-93702-x.Full Text Link to Item
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Mu, Zekun, Barton F. Haynes, and Derek W. Cain. “HIV mRNA Vaccines-Progress and Future Paths.” Vaccines (Basel) 9, no. 2 (February 7, 2021). https://doi.org/10.3390/vaccines9020134.Full Text Link to Item
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Li, Dapeng, Todd Bradley, Derek W. Cain, Isabela Pedroza-Pacheco, Maria Aggelakopoulou, Robert Parks, Maggie Barr, et al. “RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.” Immunohorizons 4, no. 11 (November 10, 2020): 713–28. https://doi.org/10.4049/immunohorizons.2000088.Full Text Link to Item
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Cain, Derek W., and John A. Cidlowski. “After 62 years of regulating immunity, dexamethasone meets COVID-19.” Nat Rev Immunol 20, no. 10 (October 2020): 587–88. https://doi.org/10.1038/s41577-020-00421-x.Full Text Link to Item
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Cain, Derek W., Carl D. Bortner, David Diaz-Jimenez, Maria G. Petrillo, Amanda Gruver-Yates, and John A. Cidlowski. “Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood.” J Immunol 205, no. 3 (August 1, 2020): 619–29. https://doi.org/10.4049/jimmunol.1901135.Full Text Link to Item
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Tian, Ming, Kelly McGovern, Hwei-Ling Cheng, Peyton Waddicor, Lisa Rieble, Mai Dao, Yiwei Chen, et al. “Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.” Proc Natl Acad Sci U S A 117, no. 14 (April 7, 2020): 7929–40. https://doi.org/10.1073/pnas.1921996117.Full Text Link to Item
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Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.Full Text Open Access Copy Link to Item
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Han, Qifeng, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, et al. “Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.” Cell Rep 30, no. 5 (February 4, 2020): 1553-1569.e6. https://doi.org/10.1016/j.celrep.2019.12.091.Full Text Open Access Copy Link to Item
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Saunders, Kevin O., Kevin Wiehe, Ming Tian, Priyamvada Acharya, Todd Bradley, S Munir Alam, Eden P. Go, et al. “Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.” Science 366, no. 6470 (December 6, 2019). https://doi.org/10.1126/science.aay7199.Full Text Link to Item
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Nelson, Ashley N., Ria Goswami, Maria Dennis, Joshua Tu, Riley J. Mangan, Pooja T. Saha, Derek W. Cain, et al. “Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.” J Virol 93, no. 15 (August 1, 2019). https://doi.org/10.1128/JVI.00168-19.Full Text Link to Item
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Pardi, Norbert, Celia C. LaBranche, Guido Ferrari, Derek W. Cain, István Tombácz, Robert J. Parks, Hiromi Muramatsu, et al. “Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques.” Mol Ther Nucleic Acids 15 (April 15, 2019): 36–47. https://doi.org/10.1016/j.omtn.2019.03.003.Full Text Link to Item
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Busada, Jonathan T., Sivapriya Ramamoorthy, Derek W. Cain, Xiaojiang Xu, Donald N. Cook, and John A. Cidlowski. “Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation.” J Clin Invest 129, no. 3 (March 1, 2019): 1345–58. https://doi.org/10.1172/JCI123233.Full Text Link to Item
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Bradley, Todd, Dimitra Peppa, Isabela Pedroza-Pacheco, Dapeng Li, Derek W. Cain, Ricardo Henao, Vaishnavi Venkat, et al. “RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.” Cell 175, no. 2 (October 4, 2018): 387-399.e17. https://doi.org/10.1016/j.cell.2018.08.064.Full Text Link to Item
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Pardi, Norbert, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia Jones, M Anthony Moody, et al. “Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.” J Exp Med 215, no. 6 (June 4, 2018): 1571–88. https://doi.org/10.1084/jem.20171450.Full Text Link to Item
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Saunders, Kevin O., Laurent K. Verkoczy, Chuancang Jiang, Jinsong Zhang, Robert Parks, Haiyan Chen, Max Housman, et al. “Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.” Cell Rep 21, no. 13 (December 26, 2017): 3681–90. https://doi.org/10.1016/j.celrep.2017.12.028.Full Text Link to Item
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Azzam, Kathleen M., Jennifer H. Madenspacher, Derek W. Cain, Lihua Lai, Kymberly M. Gowdy, Prashant Rai, Kyathanahalli Janardhan, et al. “Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.” Jci Insight 2, no. 16 (August 17, 2017). https://doi.org/10.1172/jci.insight.91914.Full Text Link to Item
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Cain, Derek W., and John A. Cidlowski. “Immune regulation by glucocorticoids.” Nat Rev Immunol 17, no. 4 (April 2017): 233–47. https://doi.org/10.1038/nri.2017.1.Full Text Link to Item
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Abbott, Robert K., Murillo Silva, Jasmine Labuda, Molly Thayer, Derek W. Cain, Phaethon Philbrook, Shalini Sethumadhavan, Stephen Hatfield, Akio Ohta, and Michail Sitkovsky. “The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.” J Biol Chem 292, no. 4 (January 27, 2017): 1211–17. https://doi.org/10.1074/jbc.C116.764043.Full Text Link to Item
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Abbott, Robert K., Molly Thayer, Jasmine Labuda, Murillo Silva, Phaethon Philbrook, Derek W. Cain, Hidefumi Kojima, et al. “Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.” J Immunol 197, no. 10 (November 15, 2016): 4014–20. https://doi.org/10.4049/jimmunol.1601401.Full Text Link to Item
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Bortner, C. D., A. B. Scoltock, D. W. Cain, and J. A. Cidlowski. “T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways.” Cell Death Differ 23, no. 5 (May 2016): 889–902. https://doi.org/10.1038/cdd.2015.156.Full Text Link to Item
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Alexander, Stephen Ph, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, et al. “The Concise Guide to PHARMACOLOGY 2015/16: Overview.” Br J Pharmacol 172, no. 24 (December 2015): 5729–43. https://doi.org/10.1111/bph.13347.Full Text Link to Item
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Cain, Derek W., and John A. Cidlowski. “Specificity and sensitivity of glucocorticoid signaling in health and disease.” Best Pract Res Clin Endocrinol Metab 29, no. 4 (August 2015): 545–56. https://doi.org/10.1016/j.beem.2015.04.007.Full Text Link to Item
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Cain, Derek W., Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn, and Garnett Kelsoe. “Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.” J Immunol 191, no. 9 (November 1, 2013): 4665–75. https://doi.org/10.4049/jimmunol.1300581.Full Text Link to Item
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Kim, Mikyung, Likai Song, James Moon, Zhen-Yu J. Sun, Anna Bershteyn, Melissa Hanson, Derek Cain, et al. “Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.” J Biol Chem 288, no. 44 (November 1, 2013): 31888–901. https://doi.org/10.1074/jbc.M113.494609.Full Text Link to Item
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Yang, Guang, T Matt Holl, Yang Liu, Yi Li, Xiaozhi Lu, Nathan I. Nicely, Thomas B. Kepler, et al. “Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.” J Exp Med 210, no. 2 (February 11, 2013): 241–56. https://doi.org/10.1084/jem.20121977.Full Text Open Access Copy Link to Item
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Cain, Derek W., Sergio E. Sanders, Michael M. Cunningham, and Garnett Kelsoe. “Disparate adjuvant properties among three formulations of "alum".” Vaccine 31, no. 4 (January 11, 2013): 653–60. https://doi.org/10.1016/j.vaccine.2012.11.044.Full Text Link to Item
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Cain, Derek W., and Michael D. Gunn. “NUR who? An orphan transcription factor holds promise for monomaniacs.” Nat Immunol 12, no. 8 (July 19, 2011): 727–29. https://doi.org/10.1038/ni.2074.Full Text Link to Item
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Kuraoka, Masayuki, T Matt Holl, Dongmei Liao, Mandy Womble, Derek W. Cain, Alexander E. Reynolds, and Garnett Kelsoe. “Activation-induced cytidine deaminase mediates central tolerance in B cells.” Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11560–65. https://doi.org/10.1073/pnas.1102571108.Full Text Link to Item
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Cain, Derek W., Pilar B. Snowden, Gregory D. Sempowski, and Garnett Kelsoe. “Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.” Plos One 6, no. 5 (2011): e19957. https://doi.org/10.1371/journal.pone.0019957.Full Text Open Access Copy Link to Item
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Kelsoe, Garnett, and Derek Cain. “A new guise for hyper-IgM syndrome.” Blood 116, no. 26 (December 23, 2010): 5785–86. https://doi.org/10.1182/blood-2010-09-303404.Full Text Link to Item
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Ledford, Julie G., Bernice Lo, Michele M. Kislan, Joseph M. Thomas, Katherine Evans, Derek W. Cain, Monica Kraft, Kristi L. Williams, and Jo Rae Wright. “Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity.” J Immunol 185, no. 7 (October 1, 2010): 3884–94. https://doi.org/10.4049/jimmunol.1000387.Full Text Link to Item
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Chen, Huaiyong, Dongmei Liao, Derek Cain, Ian McLeod, Yoshihiro Ueda, Ziqiang Guan, Christian Raetz, and Garnett Kelsoe. “Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane.” Int J Exp Pathol 91, no. 5 (October 2010): 460–71. https://doi.org/10.1111/j.1365-2613.2010.00725.x.Full Text Link to Item
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Ueda, Yoshihiro, Derek W. Cain, Masayuki Kuraoka, Motonari Kondo, and Garnett Kelsoe. “IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.” J Immunol 182, no. 10 (May 15, 2009): 6477–84. https://doi.org/10.4049/jimmunol.0803961.Full Text Link to Item
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Cain, Derek, Motonari Kondo, Huaiyong Chen, and Garnett Kelsoe. “Effects of acute and chronic inflammation on B-cell development and differentiation.” J Invest Dermatol 129, no. 2 (February 2009): 266–77. https://doi.org/10.1038/jid.2008.286.Full Text Link to Item
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Sackstein, Robert, Jasmeen S. Merzaban, Derek W. Cain, Nilesh M. Dagia, Joel A. Spencer, Charles P. Lin, and Roland Wohlgemuth. “Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.” Nat Med 14, no. 2 (February 2008): 181–87. https://doi.org/10.1038/nm1703.Full Text Link to Item
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Schreiber, Taylor H., Vera Shinder, Derek W. Cain, Ronen Alon, and Robert Sackstein. “Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.” Blood 109, no. 4 (February 15, 2007): 1381–86. https://doi.org/10.1182/blood-2006-07-032995.Full Text Link to Item
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Hamaguchi, Yasuhito, Junji Uchida, Derek W. Cain, Guglielmo M. Venturi, Jonathan C. Poe, Karen M. Haas, and Thomas F. Tedder. “The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice.” J Immunol 174, no. 7 (April 1, 2005): 4389–99. https://doi.org/10.4049/jimmunol.174.7.4389.Full Text Link to Item
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- Scholarly, Clinical, & Service Activities
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Service to Duke
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