Derek Wilson Cain | Scholars@Duke

Derek Wilson Cain
Associate Professor in Medicine

My research focuses on the interactions of T cells and B cells during infection or following vaccination. I am particularly interested in the inter- and intracellular events that take place within germinal centers, the anatomic site of antibody evolution during an immune response.

Current Appointments & Affiliations

Associate Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2021
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2016

Contact Information

2 Genome Ct - Rm 4083 MSRBII, Durham, NC 27710
Box 103020, Durham, NC 27710
(919) 681-8193
Visit the DHVI Flow Cytometry Facility website

Background
Education, Training, & Certifications
- Ph.D., Duke University 2010
Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2021
- Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2016 - 2020
- Consulting Associate in the School of Nursing, School of Nursing, Duke University 2014 - 2016
Expertise
Subject Headings
Research
Selected Grants
- SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens awarded by National Institutes of Health 2022 - 2027
- Natural killer cell regulation of the germinal center HIV neutralizing antibody response awarded by The Children's Mercy Hospital 2019 - 2023
- CIVICS Component A - Option 3 awarded by National Institutes of Health 2019 - 2023
- Targeting natural killer cells to enhance HIV vaccine responses awarded by Cincinnati Children's Hospital Medical Center 2019 - 2023
- Neonatal Immunity to novel TF SHIVs awarded by National Institutes of Health 2018 - 2023
- Langorin-eOD project awarded by Vaccine Research Institute 2019 - 2020
- Natural killer cell regulation of the germinal center HIV neutralizing antibody response awarded by The Children's Mercy Hospital 2019
- P186 Research Analysis awarded by Tulane University 2018
- Eliciting B cells to produce anti-HIV gp41 MPER-specific neutralizing antibodies, Identifying Critical Stages in Vaccine Indcued HIV-1 Immunity - Project 4 awarded by Dana-Farber Cancer Institute 2010 - 2015
- B-cell Tolerance and Humoral Immunity to HIV-1 awarded by National Institutes of Health 2009 - 2014
- Analysis of the Murine Antibody Repertoire awarded by National Institutes of Health 2009 - 2011
- Analysis of the Murine Antibody Repertoire awarded by National Institutes of Health 1989 - 2008
- The Role of Complement in Autoimmunity awarded by National Institutes of Health 2001 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hora, Bhavna, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, et al. “Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies.” Cell Rep 42, no. 3 (March 28, 2023): 112255. https://doi.org/10.1016/j.celrep.2023.112255.
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  - Bibollet-Ruche, Frederic, Ronnie M. Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, et al. “A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.” Mbio 14, no. 1 (February 28, 2023): e0337022. https://doi.org/10.1128/mbio.03370-22.
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  - Li, Dapeng, David R. Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, et al. “Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.” Nat Commun 13, no. 1 (October 23, 2022): 6309. https://doi.org/10.1038/s41467-022-33985-4.
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  - Saunders, Kevin O., Robert J. Edwards, Kedamawit Tilahun, Kartik Manne, Xiaozhi Lu, Derek W. Cain, Kevin Wiehe, et al. “Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.” Sci Transl Med 14, no. 661 (September 7, 2022): eabo5598. https://doi.org/10.1126/scitranslmed.abo5598.
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  - Li, Dapeng, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, et al. “Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.” Commun Biol 5, no. 1 (March 28, 2022): 271. https://doi.org/10.1038/s42003-022-03183-5.
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  - Mu, Zekun, Kevin Wiehe, Kevin O. Saunders, Rory Henderson, Derek W. Cain, Robert Parks, Diana Martik, et al. “mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.” Cell Rep 38, no. 11 (March 15, 2022): 110514. https://doi.org/10.1016/j.celrep.2022.110514.
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  - Mu, Zekun, Barton F. Haynes, and Derek W. Cain. “Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination.” Curr Opin Virol 51 (December 2021): 172–78. https://doi.org/10.1016/j.coviro.2021.09.015.
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  - Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.
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  - Fries, Chelsea N., Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, et al. “HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.” Sci Rep 11, no. 1 (July 14, 2021): 14494. https://doi.org/10.1038/s41598-021-93702-x.
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  - Mu, Zekun, Barton F. Haynes, and Derek W. Cain. “HIV mRNA Vaccines-Progress and Future Paths.” Vaccines (Basel) 9, no. 2 (February 7, 2021). https://doi.org/10.3390/vaccines9020134.
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  - Li, Dapeng, Todd Bradley, Derek W. Cain, Isabela Pedroza-Pacheco, Maria Aggelakopoulou, Robert Parks, Maggie Barr, et al. “RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.” Immunohorizons 4, no. 11 (November 10, 2020): 713–28. https://doi.org/10.4049/immunohorizons.2000088.
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  - Cain, Derek W., and John A. Cidlowski. “After 62 years of regulating immunity, dexamethasone meets COVID-19.” Nat Rev Immunol 20, no. 10 (October 2020): 587–88. https://doi.org/10.1038/s41577-020-00421-x.
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  - Cain, Derek W., Carl D. Bortner, David Diaz-Jimenez, Maria G. Petrillo, Amanda Gruver-Yates, and John A. Cidlowski. “Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood.” J Immunol 205, no. 3 (August 1, 2020): 619–29. https://doi.org/10.4049/jimmunol.1901135.
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  - Tian, Ming, Kelly McGovern, Hwei-Ling Cheng, Peyton Waddicor, Lisa Rieble, Mai Dao, Yiwei Chen, et al. “Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.” Proc Natl Acad Sci U S A 117, no. 14 (April 7, 2020): 7929–40. https://doi.org/10.1073/pnas.1921996117.
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  - Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.
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  - Han, Qifeng, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, et al. “Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.” Cell Rep 30, no. 5 (February 4, 2020): 1553-1569.e6. https://doi.org/10.1016/j.celrep.2019.12.091.
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  - Saunders, Kevin O., Kevin Wiehe, Ming Tian, Priyamvada Acharya, Todd Bradley, S Munir Alam, Eden P. Go, et al. “Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.” Science 366, no. 6470 (December 6, 2019). https://doi.org/10.1126/science.aay7199.
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  - Nelson, Ashley N., Ria Goswami, Maria Dennis, Joshua Tu, Riley J. Mangan, Pooja T. Saha, Derek W. Cain, et al. “Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.” J Virol 93, no. 15 (August 1, 2019). https://doi.org/10.1128/JVI.00168-19.
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  - Pardi, Norbert, Celia C. LaBranche, Guido Ferrari, Derek W. Cain, István Tombácz, Robert J. Parks, Hiromi Muramatsu, et al. “Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques.” Mol Ther Nucleic Acids 15 (April 15, 2019): 36–47. https://doi.org/10.1016/j.omtn.2019.03.003.
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  - Busada, Jonathan T., Sivapriya Ramamoorthy, Derek W. Cain, Xiaojiang Xu, Donald N. Cook, and John A. Cidlowski. “Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation.” J Clin Invest 129, no. 3 (March 1, 2019): 1345–58. https://doi.org/10.1172/JCI123233.
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  - Bradley, Todd, Dimitra Peppa, Isabela Pedroza-Pacheco, Dapeng Li, Derek W. Cain, Ricardo Henao, Vaishnavi Venkat, et al. “RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.” Cell 175, no. 2 (October 4, 2018): 387-399.e17. https://doi.org/10.1016/j.cell.2018.08.064.
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  - Pardi, Norbert, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia Jones, M Anthony Moody, et al. “Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.” J Exp Med 215, no. 6 (June 4, 2018): 1571–88. https://doi.org/10.1084/jem.20171450.
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  - Saunders, Kevin O., Laurent K. Verkoczy, Chuancang Jiang, Jinsong Zhang, Robert Parks, Haiyan Chen, Max Housman, et al. “Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.” Cell Rep 21, no. 13 (December 26, 2017): 3681–90. https://doi.org/10.1016/j.celrep.2017.12.028.
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  - Azzam, Kathleen M., Jennifer H. Madenspacher, Derek W. Cain, Lihua Lai, Kymberly M. Gowdy, Prashant Rai, Kyathanahalli Janardhan, et al. “Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.” Jci Insight 2, no. 16 (August 17, 2017). https://doi.org/10.1172/jci.insight.91914.
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  - Cain, Derek W., and John A. Cidlowski. “Immune regulation by glucocorticoids.” Nat Rev Immunol 17, no. 4 (April 2017): 233–47. https://doi.org/10.1038/nri.2017.1.
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  - Abbott, Robert K., Murillo Silva, Jasmine Labuda, Molly Thayer, Derek W. Cain, Phaethon Philbrook, Shalini Sethumadhavan, Stephen Hatfield, Akio Ohta, and Michail Sitkovsky. “The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.” J Biol Chem 292, no. 4 (January 27, 2017): 1211–17. https://doi.org/10.1074/jbc.C116.764043.
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  - Abbott, Robert K., Molly Thayer, Jasmine Labuda, Murillo Silva, Phaethon Philbrook, Derek W. Cain, Hidefumi Kojima, et al. “Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.” J Immunol 197, no. 10 (November 15, 2016): 4014–20. https://doi.org/10.4049/jimmunol.1601401.
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  - Bortner, C. D., A. B. Scoltock, D. W. Cain, and J. A. Cidlowski. “T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways.” Cell Death Differ 23, no. 5 (May 2016): 889–902. https://doi.org/10.1038/cdd.2015.156.
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  - Alexander, Stephen Ph, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, et al. “The Concise Guide to PHARMACOLOGY 2015/16: Overview.” Br J Pharmacol 172, no. 24 (December 2015): 5729–43. https://doi.org/10.1111/bph.13347.
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  - Cain, Derek W., and John A. Cidlowski. “Specificity and sensitivity of glucocorticoid signaling in health and disease.” Best Pract Res Clin Endocrinol Metab 29, no. 4 (August 2015): 545–56. https://doi.org/10.1016/j.beem.2015.04.007.
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  - Cain, Derek W., Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn, and Garnett Kelsoe. “Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.” J Immunol 191, no. 9 (November 1, 2013): 4665–75. https://doi.org/10.4049/jimmunol.1300581.
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  - Kim, Mikyung, Likai Song, James Moon, Zhen-Yu J. Sun, Anna Bershteyn, Melissa Hanson, Derek Cain, et al. “Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.” J Biol Chem 288, no. 44 (November 1, 2013): 31888–901. https://doi.org/10.1074/jbc.M113.494609.
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  - Yang, Guang, T Matt Holl, Yang Liu, Yi Li, Xiaozhi Lu, Nathan I. Nicely, Thomas B. Kepler, et al. “Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.” J Exp Med 210, no. 2 (February 11, 2013): 241–56. https://doi.org/10.1084/jem.20121977.
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  - Cain, Derek W., Sergio E. Sanders, Michael M. Cunningham, and Garnett Kelsoe. “Disparate adjuvant properties among three formulations of "alum".” Vaccine 31, no. 4 (January 11, 2013): 653–60. https://doi.org/10.1016/j.vaccine.2012.11.044.
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  - Cain, Derek W., and Michael D. Gunn. “NUR who? An orphan transcription factor holds promise for monomaniacs.” Nat Immunol 12, no. 8 (July 19, 2011): 727–29. https://doi.org/10.1038/ni.2074.
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  - Kuraoka, Masayuki, T Matt Holl, Dongmei Liao, Mandy Womble, Derek W. Cain, Alexander E. Reynolds, and Garnett Kelsoe. “Activation-induced cytidine deaminase mediates central tolerance in B cells.” Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11560–65. https://doi.org/10.1073/pnas.1102571108.
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  - Cain, Derek W., Pilar B. Snowden, Gregory D. Sempowski, and Garnett Kelsoe. “Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.” Plos One 6, no. 5 (2011): e19957. https://doi.org/10.1371/journal.pone.0019957.
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  - Kelsoe, Garnett, and Derek Cain. “A new guise for hyper-IgM syndrome.” Blood 116, no. 26 (December 23, 2010): 5785–86. https://doi.org/10.1182/blood-2010-09-303404.
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  - Ledford, Julie G., Bernice Lo, Michele M. Kislan, Joseph M. Thomas, Katherine Evans, Derek W. Cain, Monica Kraft, Kristi L. Williams, and Jo Rae Wright. “Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity.” J Immunol 185, no. 7 (October 1, 2010): 3884–94. https://doi.org/10.4049/jimmunol.1000387.
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  - Chen, Huaiyong, Dongmei Liao, Derek Cain, Ian McLeod, Yoshihiro Ueda, Ziqiang Guan, Christian Raetz, and Garnett Kelsoe. “Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane.” Int J Exp Pathol 91, no. 5 (October 2010): 460–71. https://doi.org/10.1111/j.1365-2613.2010.00725.x.
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  - Ueda, Yoshihiro, Derek W. Cain, Masayuki Kuraoka, Motonari Kondo, and Garnett Kelsoe. “IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.” J Immunol 182, no. 10 (May 15, 2009): 6477–84. https://doi.org/10.4049/jimmunol.0803961.
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  - Cain, Derek, Motonari Kondo, Huaiyong Chen, and Garnett Kelsoe. “Effects of acute and chronic inflammation on B-cell development and differentiation.” J Invest Dermatol 129, no. 2 (February 2009): 266–77. https://doi.org/10.1038/jid.2008.286.
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  - Sackstein, Robert, Jasmeen S. Merzaban, Derek W. Cain, Nilesh M. Dagia, Joel A. Spencer, Charles P. Lin, and Roland Wohlgemuth. “Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.” Nat Med 14, no. 2 (February 2008): 181–87. https://doi.org/10.1038/nm1703.
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  - Schreiber, Taylor H., Vera Shinder, Derek W. Cain, Ronen Alon, and Robert Sackstein. “Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.” Blood 109, no. 4 (February 15, 2007): 1381–86. https://doi.org/10.1182/blood-2006-07-032995.
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  - Hamaguchi, Yasuhito, Junji Uchida, Derek W. Cain, Guglielmo M. Venturi, Jonathan C. Poe, Karen M. Haas, and Thomas F. Tedder. “The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice.” J Immunol 174, no. 7 (April 1, 2005): 4389–99. https://doi.org/10.4049/jimmunol.174.7.4389.
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Scholarly, Clinical, & Service Activities
Service to Duke
- Occupational and Environmental Safety Office. University Research Laser Safety Committee. May 2018 2018

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Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Service to Duke