Scholars@Duke
Derek Chan

Selected Publications

Multiparametric Ultrasound Imaging of Prostate Cancer Using Deep Neural Networks.

Journal Article Ultrasound Med Biol · November 2024 OBJECTIVE: A deep neural network (DNN) was trained to generate a multiparametric ultrasound (mpUS) volume from four input ultrasound-based modalities (acoustic radiation force impulse [ARFI] imaging, shear wave elasticity imaging [SWEI], quantitative ultra ... Full text Link to item Cite

Combined ARFI and Shear Wave Imaging of Prostate Cancer: Optimizing Beam Sequences and Parameter Reconstruction Approaches.

Journal Article Ultrasonic imaging · July 2023 This study demonstrates the implementation of a shear wave reconstruction algorithm that enables concurrent acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging (SWEI) of prostate cancer and zonal anatomy. The combined ARFI/SWE ... Full text Cite

Screening and Image-Guided Targeted Biopsy of Prostate Cancer Using 3D Acoustic Radiation Force Impulse (ARFI) Imaging

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2022 We have developed a 3D acoustic radiation force impulse (ARFI) imaging system that screens for prostate cancer and provides imaging guidance for a targeted biopsy in a single clinic visit. ARFI and B-mode volumes are acquired by using a rotation stage to s ... Full text Cite

Prostate Cancer Detection Using 3-D Shear Wave Elasticity Imaging.

Journal Article Ultrasound Med Biol · July 2021 Transrectal ultrasound (TRUS) B-mode imaging provides insufficient sensitivity and specificity for prostate cancer (PCa) targeting when used for biopsy guidance. Shear wave elasticity imaging (SWEI) is an elasticity imaging technique that has been commerci ... Full text Link to item Cite

Deep Convolutional Neural Networks for Displacement Estimation in ARFI Imaging.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · July 2021 Ultrasound elasticity imaging in soft tissue with acoustic radiation force requires the estimation of displacements, typically on the order of several microns, from serially acquired raw data A-lines. In this work, we implement a fully convolutional neural ... Full text Link to item Cite

Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms.

Journal Article Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · March 2021 ObjectivesTo quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms.MethodsTwo elas ... Full text Cite

Deep neural network for multiparametric ultrasound imaging of prostate cancer

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2021 This study presents a deep neural network (DNN) for generating a multiparametric ultrasound (mpUS) volume of the prostate by combining data from acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), B-mode imaging, and quan ... Full text Cite

Multiparametric Ultrasound for Targeting Prostate Cancer: Combining ARFI, SWEI, QUS and B-Mode.

Journal Article Ultrasound Med Biol · December 2020 Diagnosing prostate cancer through standard transrectal ultrasound (TRUS)-guided biopsy is challenging because of the sensitivity and specificity limitations of B-mode imaging. We used a linear support vector machine (SVM) to combine standard TRUS imaging ... Full text Link to item Cite

Evaluating Image Quality Improvement in Multiparametric Ultrasound Imaging of Prostate Cancer by Combining ARFI, SWEI, B-mode, and QUS

Conference IEEE International Ultrasonics Symposium, IUS · September 7, 2020 This study demonstrates the application of multiparametric ultrasound (mpUS) imaging techniques for combining data from four individual modalities: acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), B-mode imaging, and q ... Full text Cite

Multiparametric Ultrasound for the Targeting of Prostate Cancer using ARFI, SWEI, B-mode, and QUS

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 Prostate cancer diagnosis using standard transrectal ultrasound (TRUS) and systematic biopsy is challenging. To improve the performance of TRUS imaging, we combined it with acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging ( ... Full text Cite

Bayesian Shear Wave Speed Reconstruction with an On-Axis ARFI Prior

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 Shear wave elasticity image quality can be degraded by poor signal-to-noise ratio or spatial resolution due to low shear wave amplitudes and reconstruction kernel size. A framework is presented for incorporating additional information about relative stiffn ... Full text Cite

A Fully Convolutional Neural Network for Rapid Displacement Estimation in ARFI Imaging

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 Ultrasound elasticity imaging in soft tissue with acoustic radiation force requires extracting displacement information, typically on the order of several microns, from raw data. In this work, we implement a fully convolutional neural network for ultrasoun ... Full text Cite

Right-Sided Versus Left-Sided Pneumonectomy After Induction Therapy for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · April 2019 BACKGROUND: A right-sided pneumonectomy after induction therapy for non-small cell lung cancer (NSCLC) has been shown to be associated with significant perioperative risk. We examined the effect of laterality on long-term survival after induction therapy a ... Full text Link to item Cite

Long-term Survival After Surgery Compared With Concurrent Chemoradiation for Node-negative Small Cell Lung Cancer.

Journal Article Ann Surg · December 2018 OBJECTIVE: To determine whether surgery with adjuvant chemotherapy offers a survival advantage over concurrent chemoradiation for patients with cT1-2N0M0 small cell lung cancer (SCLC). BACKGROUND: Although surgery with adjuvant chemotherapy is the recommen ... Full text Link to item Cite

Prostate Shear Wave Elastography: Multiresolution Reconstruction Dependence on Push Beam Spacing

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2018 This study demonstrates the implementation of a multiresolution shear wave tracking algorithm that enables elasticity imaging of prostate cancer and zonal anatomy. The combined ARFI/SWEI sequence uses closely-spaced push beams across the lateral field of v ... Full text Cite

Correlation Between 3D ARFI and Quantitative Imaging Metrics from SWEI and Multi-Parametric MRI in Vivo in Normal and Cancerous Prostate Tissue

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2018 Prostate lesions and healthy regions from 12 radical prostatectomy patients were identified in acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), and multi-parametric magnetic resonance imaging (mpMRI) apparent diffusion ... Full text Cite

Surgery Versus Optimal Medical Management for N1 Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · June 2017 BACKGROUND: Adjuvant chemotherapy has been demonstrated to improve the outcomes of patients with N1 non-small cell lung cancer. It is unknown whether patients previously thought to have unresectable small cell lung cancer (SCLC) may have tumors amenable to ... Full text Link to item Cite

Reply to D.A. Palma.

Journal Article J Clin Oncol · February 10, 2017 Full text Link to item Cite

Reply to T.-H. Wang et al.

Journal Article J Clin Oncol · January 2017 Full text Link to item Cite

Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer.

Journal Article J Clin Oncol · April 1, 2016 PURPOSE: Data on optimal adjuvant therapy after complete resection of small-cell lung cancer (SCLC) are limited, and in particular, there have been no studies evaluating the role of adjuvant chemotherapy, with or without prophylactic cranial irradiation, r ... Full text Link to item Cite