Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Virginia 1978
• 

  Previous Appointments & Affiliations

  • Associate Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2013 - 2017
  • Assistant Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2006 - 2013
  • Assistant Research Professor in Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2003 - 2006
  • Instructor, Temporary of Pediatrics, Pediatrics, Clinical Science Departments 2002
• Research
• 

  Selected Grants

  • Phase I Serum-free cultured thymus transplantation in DiGeorge anomaly, IND9836, Feb 5, 2008 awarded by National Institutes of Health 2009 - 2011
  • Thymic Transplantation in Complete DiGeorge Syndrome awarded by National Institutes of Health 2009 - 2010
  • Dynamics of TCR Repertoire Following Thymus Transplant awarded by National Institutes of Health 2004 - 2009
  • Dose Study of Thymus Transplantation, IND 9836 awarded by Food and Drug Administration 2005 - 2008
  • Parathyroid and Thymus Transplants in DiGeorge Syndrome awarded by National Institutes of Health 2004 - 2006
  • Thymic Transplantation in Complete DiGeorge Syndrome awarded by National Institutes of Health 1999 - 2004
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Davies, E Graham, Melissa Cheung, Kimberly Gilmour, Jesmeen Maimaris, Joe Curry, Anna Furmanski, Neil Sebire, et al. “Thymus transplantation for complete DiGeorge syndrome: European experience.” J Allergy Clin Immunol 140, no. 6 (December 2017): 1660-1670.e16. https://doi.org/10.1016/j.jaci.2017.03.020.
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    • Ciupe, Stanca M., Blythe H. Devlin, Mary Louise Markert, and Thomas B. Kepler. “Quantification of total T-cell receptor diversity by flow cytometry and spectratyping.” Bmc Immunol 14 (August 6, 2013): 35. https://doi.org/10.1186/1471-2172-14-35.
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    • Markert, M Louise, Stephanie E. Gupton, Elizabeth A. McCarthy, Blythe H. Devlin, Chia-san Hsieh, Jie Li, Troy R. Torgerson, Hans D. Ochs, and Rebecca H. Buckley. “RESPONSE TO BACTERIOPHAGE Phi chi 174 IN CHILDREN WITH PARTIAL DIGEORGE ANOMALY AND IN CHILDREN WITH COMPLETE DIGEORGE ANOMALY AFTER CULTURED POSTNATAL ALLOGENEIC THYMUS TRANSPLANTATION.” Journal of Clinical Immunology 33, no. 3 (April 1, 2013): 679–80.
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    • McCarthy, Elizabeth A., Chia-san Hsieh, Jie Li, Stephanie E. Gupton, Blythe H. Devlin, Alain Fischer, Despina Moshous, and M Louise Markert. “THYMUS TRANSPLANTATION IN A THREE YEAR OLD CHILD WHO DID NOT DEVELOP SUFFICIENT NAIVE CD4 T CELLS AFTER PARENTAL BONE MARROW STEM CELL TRANSPLANTATION.” Journal of Clinical Immunology 33, no. 3 (April 1, 2013): 676–676.
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    • Heimall, Jennifer, Michael Keller, Rushani Saltzman, Nancy Bunin, Donna McDonald-McGinn, Elaine Zakai, Jean-Pierre de Villartay, et al. “Diagnosis of 22q11.2 deletion syndrome and artemis deficiency in two children with T-B-NK+ immunodeficiency.” J Clin Immunol 32, no. 5 (October 2012): 1141–44. https://doi.org/10.1007/s10875-012-9741-9.
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    • Albuquerque, Adriana S., José G. Marques, Susana L. Silva, Dario Ligeiro, Blythe H. Devlin, Jacques Dutrieux, Rémi Cheynier, et al. “Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.” Plos One 7, no. 5 (2012): e37042. https://doi.org/10.1371/journal.pone.0037042.
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    • Li, Bin, Jie Li, Blythe H. Devlin, and M Louise Markert. “Thymic microenvironment reconstitution after postnatal human thymus transplantation.” Clin Immunol 140, no. 3 (September 2011): 244–59. https://doi.org/10.1016/j.clim.2011.04.004.
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    • Markert, M Louise, José G. Marques, Bénédicte Neven, Blythe H. Devlin, Elizabeth A. McCarthy, Ivan K. Chinn, Adriana S. Albuquerque, et al. “First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases.” Blood 117, no. 2 (January 13, 2011): 688–96. https://doi.org/10.1182/blood-2010-06-292490.
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    • Chinn, Ivan K., John A. Olson, Michael A. Skinner, Elizabeth A. McCarthy, Stephanie E. Gupton, Dong-Feng Chen, Francisco A. Bonilla, et al. “Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation.” J Allergy Clin Immunol 126, no. 4 (October 2010): 814-820.e8. https://doi.org/10.1016/j.jaci.2010.07.016.
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    • Markert, M Louise, Blythe H. Devlin, and Elizabeth A. McCarthy. “Thymus transplantation.” Clin Immunol 135, no. 2 (May 2010): 236–46. https://doi.org/10.1016/j.clim.2010.02.007.
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    • Ciupe, Stanca M., Blythe H. Devlin, M Louise Markert, and Thomas B. Kepler. “The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly.” Plos Comput Biol 5, no. 6 (June 2009): e1000396. https://doi.org/10.1371/journal.pcbi.1000396.
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    • Li, Bin, Jie Li, Chia-San Hsieh, Laura P. Hale, Yi-Ju Li, Blythe H. Devlin, and M Louise Markert. “Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes.” Immunol Res 44, no. 1–3 (2009): 71–83. https://doi.org/10.1007/s12026-008-8083-4.
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    • Markert, M Louise, Blythe H. Devlin, Ivan K. Chinn, and Elizabeth A. McCarthy. “Thymus transplantation in complete DiGeorge anomaly.” Immunol Res 44, no. 1–3 (2009): 61–70. https://doi.org/10.1007/s12026-008-8082-5.
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    • Markert, M. L., B. H. Devlin, E. A. McCarthy, I. K. Chinn, and L. P. Hale. “Thymus transplantation,” December 1, 2008, 255–67. https://doi.org/10.1007/978-88-470-0828-1_30.
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    • Markert, M. L., and B. H. Devlin. “Thymic reconstitution,” December 1, 2008, 1253–61. https://doi.org/10.1016/B978-0-323-04404-2.10084-3.
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    • Albuquerque, A. S., J. G. Marques, S. L. Silva, I. K. Chinn, B. H. Devlin, R. Cheynier, C. Pignata, R. M. Victorino, M. L. Markert, and A. E. Sousa. “Immunological reconstitution following thymic transplantation of a nude/SCID patient.” Clinical and Experimental Immunology 154 (November 1, 2008): 36–36.
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    • Markert, M. L., B. H. Devlin, I. K. Chinn, E. A. McCarthy, and Y. J. Li. “Factors affecting success of thymus transplantation for complete DiGeorge anomaly.” Am J Transplant 8, no. 8 (August 2008): 1729–36. https://doi.org/10.1111/j.1600-6143.2008.02301.x.
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    • Markert, M Louise, Jie Li, Blythe H. Devlin, Jeffrey C. Hoehner, Henry E. Rice, Michael A. Skinner, Yi-Ju Li, and Laura P. Hale. “Use of allograft biopsies to assess thymopoiesis after thymus transplantation.” J Immunol 180, no. 9 (May 1, 2008): 6354–64. https://doi.org/10.4049/jimmunol.180.9.6354.
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    • Chinn, Ivan K., Blythe H. Devlin, Yi-Ju Li, and M Louise Markert. “Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly.” Clin Immunol 126, no. 3 (March 2008): 277–81. https://doi.org/10.1016/j.clim.2007.11.009.
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    • Hudson, Lori L., M. Louise Markert, Blythe H. Devlin, Barton F. Haynes, and Gregory D. Sempowski. “Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.” Semin Immunol 19, no. 5 (October 2007): 297–309. https://doi.org/10.1016/j.smim.2007.10.002.
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    • Markert, M Louise, Blythe H. Devlin, Marilyn J. Alexieff, Jie Li, Elizabeth A. McCarthy, Stephanie E. Gupton, Ivan K. Chinn, et al. “Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants.” Blood 109, no. 10 (May 15, 2007): 4539–47. https://doi.org/10.1182/blood-2006-10-048652.
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    • He, Min, John K. Tomfohr, Blythe H. Devlin, Marcella Sarzotti, M Louise Markert, and Thomas B. Kepler. “SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization.” Bioinformatics 21, no. 18 (September 15, 2005): 3697–99. https://doi.org/10.1093/bioinformatics/bti600.
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    • Kepler, Thomas B., Min He, John K. Tomfohr, Blythe H. Devlin, Marcella Sarzotti, and M Louise Markert. “Statistical analysis of antigen receptor spectratype data.” Bioinformatics 21, no. 16 (August 15, 2005): 3394–3400. https://doi.org/10.1093/bioinformatics/bti539.
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    • Markert, M Louise, Marilyn J. Alexieff, Jie Li, Marcella Sarzotti, Daniel A. Ozaki, Blythe H. Devlin, Debra A. Sedlak, et al. “Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome.” Blood 104, no. 8 (October 15, 2004): 2574–81. https://doi.org/10.1182/blood-2003-08-2984.
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    • Markert, M Louise, Marilyn J. Alexieff, Jie Li, Marcella Sarzotti, Daniel A. Ozaki, Blythe H. Devlin, Gregory D. Sempowski, et al. “Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases.” J Allergy Clin Immunol 113, no. 4 (April 2004): 734–41. https://doi.org/10.1016/j.jaci.2004.01.766.
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    • Cegielski, J. P., B. H. Devlin, A. J. Morris, J. N. Kitinya, U. P. Pulipaka, L. E. Lema, J. Lwakatare, and L. B. Reller. “Comparison of PCR, culture, and histopathology for diagnosis of tuberculous pericarditis.” J Clin Microbiol 35, no. 12 (December 1997): 3254–57. https://doi.org/10.1128/jcm.35.12.3254-3257.1997.
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    • Sundv, J. S., T. S. Barry, D. D. Patel, N. B. Allen, B. Devlin, S. Bigner, R. E. Kaufman, and B. F. Haynes. “Myotropic Th1 T helper cell lymphoma presenting as granulomatous inflammatory masses in synovium and muscle.” Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
    • Devlin, B. H., H. Ratech, and R. Kaufman. “Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies.” Diagn Mol Pathol 3, no. 4 (December 1994): 271–74. https://doi.org/10.1097/00019606-199412000-00010.
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    • Castro, C. M. de, B. Devlin, D. E. Fleenor, M. E. Lee, and R. E. Kaufman. “A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype.” Blood 83, no. 4 (February 15, 1994): 1109–16.
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    • Morris, A., L. Reller, and B. Devlin. “Clinical usefulness of detecting growth of Mycobacterium tuberculosis in positive Bactec phials using PCR.” J Clin Pathol 47, no. 2 (February 1994): 190–91. https://doi.org/10.1136/jcp.47.2.190.
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    • Bentley, R. C., B. Devlin, R. E. Kaufman, M. Borowitz, and H. Ratech. “Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes.” Hum Pathol 24, no. 6 (June 1993): 675–78. https://doi.org/10.1016/0046-8177(93)90249-g.
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    • WEFALD, F. C., W. E. KRAUS, T. S. BERNARD, B. H. DEVLIN, and R. S. WILLIAMS. “TRANS-INACTIVATION OF THE MYOGLOBIN MUSCLE-SPECIFIC ENHANCER BY THE TRANSCRIPTIONAL REPRESSOR GCF.” Circulation 82, no. 4 (October 1, 1990): 106–106.
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    • Wefald, F. C., B. H. Devlin, and R. S. Williams. “Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer.” Nature 344, no. 6263 (March 15, 1990): 260–62. https://doi.org/10.1038/344260a0.
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    • Devlin, B. H., F. C. Wefald, W. E. Kraus, T. S. Bernard, and R. S. Williams. “Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene.” J Biol Chem 264, no. 23 (August 15, 1989): 13896–901.
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    • Devlin, B. H., and I. R. Konigsberg. “Reentry into the cell cycle of differentiated skeletal myocytes.” Dev Biol 95, no. 1 (January 1983): 175–92. https://doi.org/10.1016/0012-1606(83)90016-7.
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    • Devlin, B. H., B. R. Baumstark, and J. R. Scott. “Superimmunity: characterization of a new gene in the immunity region of P1.” Virology 120, no. 2 (July 30, 1982): 360–75. https://doi.org/10.1016/0042-6822(82)90037-x.
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  • Book Sections

    • Markert, M. L., B. H. Devlin, and E. A. McCarthy. “Thymic reconstitution.” In Clinical Immunology: Principles and Practice: Fourth Edition, 1032–38, 2013. https://doi.org/10.1016/B978-0-7234-3691-1.00023-4.
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    • Markert, M. L., and B. H. Devlin. “Thymic reconstitution: Characteristics of Naive T Cells.” In Clinical Immunology: Principles and Practice Expert Consult: Online and Print, 1253–61, 2008. https://doi.org/10.1016/B978-0-323-04404-2.10084-3.
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  • Conference Papers

    • Markert, M. L., B. H. Devlin, and E. A. McCarthy. “Thymus Defects/Transplant and Problems Associated with Immune Reconstitution.” In Proceedings of the 15th Meeting of the European Society Immunodeficiencies (Esid), edited by A. Etzioni and E. Gambineri, 99–104. MEDIMOND S R L, 2013.
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    • Chinn, I. K., J. A. Olson, M. A. Skinner, E. A. McCarthy, S. E. Gupton, F. A. Bonilla, R. L. Roberts, M. G. Kanariou, B. H. Devlin, and M. L. Markert. “Mechanisms of Tolerance to Parental Parathyroid Tissue when Combined with Human Allogeneic Thymus Transplantation.” In Journal of Allergy and Clinical Immunology, 125:AB55–AB55. Elsevier BV, 2010. https://doi.org/10.1016/j.jaci.2009.12.252.
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    • Li, Bin, Jie Li, Blythe H. Devlin, and Mary Louise Markert. “MHC class I restriction in DiGeorge anomaly patients after allogeneic thymus transplantation.” In Journal of Immunology, Vol. 182. AMER ASSOC IMMUNOLOGISTS, 2009.
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    • CHINN, I., J. OLSONJR, M. SKINNER, E. MCCARTHY, S. GUPTON, F. BONILLA, R. ROBERTS, M. KANARIOU, B. DEVLIN, and M. MARKERT. “Combined Thymus and Parathyroid Allotransplantation in Complete DiGeorge Anomaly.” In Journal of Allergy and Clinical Immunology, 121:S269–S269. Elsevier BV, 2008. https://doi.org/10.1016/j.jaci.2007.12.1067.
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    • Chinn, I. K., B. H. Devlin, M. J. Alexieff, J. Li, S. E. Gupton, E. A. McCarthy, and M. L. Markert. “Tolerance To Allogeneic Thymus Transplantation In Complete DiGeorge Syndrome.” In Journal of Allergy and Clinical Immunology, 119:S12–S12. Elsevier BV, 2007. https://doi.org/10.1016/j.jaci.2006.11.062.
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    • Chinn, I. K., B. H. Devlin, M. A. Alexieff, J. Li, E. McCarthy, M. A. Skinner, J. A. Olson, and M. L. Markert. “Parathyroid Gland Transplantation without Posttransplantation Immunosuppression.” In Journal of Allergy and Clinical Immunology, 117:S108–S108. Elsevier BV, 2006. https://doi.org/10.1016/j.jaci.2005.12.431.
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    • Devlin, B. H., J. Li, M. Alexieff, S. Harley, E. McCarthy, M. He, T. B. Kepler, and M. L. Markert. “Time course of normalization of T cell receptor repertoire in a complete DiGeorge syndrome patient post-thymus transplantation.” In Clinical Immunology, 116:285–86. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.
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    • Markert, M. L., B. H. Devlin, M. A. Alexieff, J. Li, E. McCarthy, M. A. Skinner, and J. A. Olson. “Parathyroid and thymus transplantation in complete DiGeorge syndrome.” In Clinical Immunology, 116:294–95. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.
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