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Blythe Hazlehurst Devlin

Blythe Hazlehurst Devlin

Associate Professor Emeritus
Pediatrics, Allergy and Immunology
devli002@mc.duke.edu
Box 3352, Durham, NC 27710
2200 W. Main Street, Wing B, Suite 220, Box 104013, Durham, NC 27705

Overview

My research interests focus on the mechanisms of thymus engraftment after transplantation of cultured, allogeneic, postnatal thymus in infants born with athymia (complete DiGeorge Syndrome). I am interested in the signals that attract progenitor cells from the host bone marrow to the transplanted thymus and the differentiation of the transplanted thymus tissue into functional, but HLA mismatched, mature thymus. My research interests also include the diversification of the T cell receptor repertoire in the peripheral blood after thymus transplantation and the mechanisms that control T cell homeostasis.

Current Appointments & Affiliations

Associate Professor Emeritus · 2017 - Present Pediatrics, Allergy and Immunology, Pediatrics

Recent Publications

Thymus transplantation for complete DiGeorge syndrome: European experience.

Journal Article J Allergy Clin Immunol · December 2017 BACKGROUND: Thymus transplantation is a promising strategy for the treatment of athymic complete DiGeorge syndrome (cDGS). METHODS: Twelve patients with cDGS underwent transplantation with allogeneic cultured thymus. OBJECTIVE: We sought to confirm and ext ... Full text Link to item Cite

Quantification of total T-cell receptor diversity by flow cytometry and spectratyping.

Journal Article BMC Immunol · August 6, 2013 BACKGROUND: T-cell receptor diversity correlates with immune competency and is of particular interest in patients undergoing immune reconstitution. Spectratyping generates data about T-cell receptor CDR3 length distribution for each BV gene but is technica ... Full text Link to item Cite
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Recent Grants

Phase I Serum-free cultured thymus transplantation in DiGeorge anomaly, IND9836, Feb 5, 2008

ResearchLaboratory Director · Awarded by National Institutes of Health · 2009 - 2011

Thymic Transplantation in Complete DiGeorge Syndrome

ResearchInvestigator · Awarded by National Institutes of Health · 2009 - 2010

Dynamics of TCR Repertoire Following Thymus Transplant

ResearchInvestigator · Awarded by National Institutes of Health · 2004 - 2009

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