Scholars@Duke
Divakar Gupta

Divakar Gupta

Associate Professor of Ophthalmology
Ophthalmology, Glaucoma
divakar.gupta@duke.edu
Duke Eye Center, DUMC 3802, Durham, NC 27710
Duke Eye Center, 2351 Erwin Road, DUMC 3802, Durham, NC 27705

Selected Publications

The Efficacy and Safety of Trabeculectomy after Failed Primary Glaucoma Drainage Devices.

Journal Article Ophthalmol Ther · August 2025 INTRODUCTION: Trabeculectomy is not usually considered for uncontrolled intraocular pressure (IOP) after glaucoma drainage devices (GDD) because of concern that the conjunctiva has been violated and future trabeculectomy surgery is likely to fail due to fi ... Full text Link to item Cite

Incident glaucoma and ocular hypertension after periocular and intravitreal steroid injections: a claims-based analysis.

Journal Article BMJ Open Ophthalmol · December 22, 2023 BACKGROUND/AIMS: This study aims to determine the incidence and risk of open-angle glaucoma or ocular hypertension (OHT) following ocular steroid injections using healthcare claims data. METHODS: We retrospectively reviewed deidentified insurance claims da ... Full text Link to item Cite

Perceptions of Respect From Clinicians by Patients in Racial and Ethnic Minority Groups With Eye Disease.

Journal Article JAMA Ophthalmol · February 1, 2022 IMPORTANCE: The perception of being treated with respect by clinicians may be a driver of disparities in individuals in racial and ethnic minoritie groups with eye diseases. Understanding these drivers may help identify potential interventions to reduce ey ... Full text Link to item Cite

Evolution of a Glaucoma Fellow's Surgical Training: Improvements in Tube Shunt Case Times during the Academic Year.

Journal Article J Acad Ophthalmol (2017) · July 2021 Purpose  The aim of the study is to report changes in tube shunt placement surgical case times for glaucoma fellows during the course of the academic year. Patients and Methods  Electronic health records were retrospectively reviewed to determine patient d ... Full text Link to item Cite

Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.

Journal Article Am J Ophthalmol · June 2021 PURPOSE: Intraocular pressure (IOP) reduction is key to controlling primary open angle glaucoma (POAG). Pharmacotherapies for POAG or ocular hypertension (OHT) commonly lower IOP by increasing uveoscleral outflow or decreasing aqueous humor production. Net ... Full text Link to item Cite

The art of imaging methods—using cutting edge radiological technology to uncover the secrets of ancient anatomical figurines

Journal Article Archaeological and Anthropological Sciences · May 1, 2021 Ivory anatomical figurines are thought to have been carved in Germany in the seventeenth or eighteenth century. While it is speculated that these figurines were used for the study of medical education, little is known about their origins. A precise underst ... Full text Cite

The Use of eHealth Practices by United States Patients with Self-Reported Glaucoma.

Journal Article Ophthalmol Glaucoma · 2021 PURPOSE: Patient-oriented eHealth practices (e.g., scheduling appointments on the Internet, communicating with providers online) are an integral part of modern healthcare delivery. It is not known what proportion of United States patients with glaucoma use ... Full text Link to item Cite

Cost-Related Medication Nonadherence in a Nationally Representative US Population with Self-Reported Glaucoma.

Journal Article Ophthalmol Glaucoma · 2021 PURPOSE: To determine the rates of cost-related nonadherence to medications among US adults with glaucoma and to determine if participants with glaucoma have more cost-related medication nonadherence than those without glaucoma. DESIGN: Cross-sectional stu ... Full text Link to item Cite

Effect of Covid 19 over Indian Domestic Power Sector: A Comprehensive Study

Conference IEEE Region 10 Humanitarian Technology Conference R10 Htc · January 1, 2021 The year 2020 will be remembered a battle for existence of mankind against a super spreading virus Covid-19. While health-workers fought from the front, power industry stood like backbone to ensure proper support to handle the crisis. The covid-19 brought ... Full text Cite

Treatment Patterns and Outcomes in Bleb-Related Endophthalmitis: A 9-Year Analysis at a Tertiary Eye Center.

Journal Article J Vitreoretin Dis · 2021 PURPOSE: Clinical presentation, treatment choices, and outcomes in cases of bleb-related endophthalmitis (BRE) at a tertiary care center over a 9-year period are described. METHODS: A retrospective review was conducted of patients diagnosed with BRE at Duk ... Full text Link to item Cite

Effect of Transformer Oil Reconditioning on Oil Properties and Dissolved Gases

Conference 2020 IEEE 17th India Council International Conference Indicon 2020 · December 10, 2020 Health assessment and life-management of transformer is one of the most discussed topic in industry. In-time action, based on oil analysis, can save costlier transformer failure or its oil replacement. Action requirement can be decided depending on the oil ... Full text Cite

Granulomatosis with polyangiitis-associated ischemic optic neuropathy in a previously healthy 50-year-old female.

Journal Article Am J Ophthalmol Case Rep · December 2020 PURPOSE: To describe a case of anterior ischemic optic neuropathy as a presenting sign of granulomatosis with polyangiitis. OBSERVATIONS: A previously healthy 50-year-old female developed right eye, then left eye, redness and pruritis and was diagnosed wit ... Full text Link to item Cite

Impact of Video Education on Patient Knowledge, Anxiety, and Satisfaction in Selective Laser Trabeculoplasty: A Pilot Study.

Journal Article J Glaucoma · December 2020 UNLABELLED: PRéCIS:: In patients undergoing selective laser trabeculoplasty, preoperative video education did not improve patient knowledge regarding the procedure, decrease anxiety, or increase satisfaction, as these metrics were already favorable across ... Full text Link to item Cite

Evaluation for Disparities in Experience With Internet-Based Health Care Among US Patients With Chronic Eye Diseases.

Journal Article JAMA Ophthalmol · October 1, 2020 This cross-sectional study assesses the proportion of US adults with self-reported eye disease who have experience using the internet for health care and evaluates differences in their experience. ... Full text Link to item Cite

Reticular Bullous Epithelial Edema in Corneas Treated with Netarsudil: A Case Series.

Journal Article Am J Ophthalmol · September 2020 PURPOSE: To describe the patient characteristics and the clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil. DESIGN: Retrospective case series. METHODS: Case series at a singl ... Full text Link to item Cite

Prospective Studies of Minimally Invasive Glaucoma Surgeries: Systematic Review and Quality Assessment.

Journal Article Clin Ophthalmol · 2020 Glaucoma is a common blinding disease; while there is no cure, effective treatments include medications, laser, and incisional surgery. There is significant interest from patients and doctors to develop safer surgical options throughout the spectrum of dis ... Full text Open Access Link to item Cite

Association of Open-Angle Glaucoma with Non-Alzheimer's Dementia and Cognitive Impairment.

Journal Article Ophthalmol Glaucoma · 2020 PURPOSE: To compare the odds of central neurodegenerative diseases in patients with open-angle glaucoma (OAG) with the odds in patients without glaucoma (control patients). DESIGN: Cross-sectional study. PARTICIPANTS: Patients 18 years of age or older who ... Full text Link to item Cite

Assessment of opacities in donor corneas using optical coherence tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Malignant Peripheral Nerve Sheath Tumor of the Lower Eyelid: Case Presentation and Literature Review.

Journal Article Ophthalmic Plast Reconstr Surg · 2017 Solitary benign neurogenic tumors are common in the orbit, but only rarely arise from peripheral nerves in the eyelids. In contrast, malignant tumors of neural or nerve sheath elements are exceedingly rare in the orbit and, to date, have never been reporte ... Full text Link to item Cite

Orbital peripheral nerve sheath tumors.

Journal Article Surv Ophthalmol · 2017 Peripheral nerve sheath tumors of the orbit and ocular adnexa are a rare group of neoplasms hallmarked by nonspecific clinical presentations, variable tumor locations, challenging therapeutic efforts, and occasional diagnostic dilemmas. We review these tum ... Full text Link to item Cite

Cytokine biomarkers in tear film for primary open-angle glaucoma.

Journal Article Clin Ophthalmol · 2017 PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucom ... Full text Open Access Link to item Cite

Combined Ahmed Glaucoma Valve Placement, Intravitreal Fluocinolone Acetonide Implantation and Cataract Extraction for Chronic Uveitis.

Journal Article J Glaucoma · October 2016 PURPOSE: To report the outcomes of combined Ahmed glaucoma valve (AGV) placement, intravitreal fluocinolone acetonide implant, and cataract extraction procedure in the treatment of chronic noninfectious uveitis. PATIENTS AND METHODS: Retrospective case ser ... Full text Link to item Cite

Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography.

Journal Article J Biomed Opt · June 1, 2016 Optical coherence tomography angiography (OCTA) has increasingly become a clinically useful technique in ophthalmic imaging. We evaluate the repeatability and reproducibility of blood perfusion in the optic nerve head (ONH) measured using optical microangi ... Full text Link to item Cite

Refusal of Trabeculectomy for the Fellow Eye in Collaborative Initial Glaucoma Treatment Study (CIGTS) Participants.

Journal Article Am J Ophthalmol · June 2016 PURPOSE: To understand the reasons for refusal of fellow eye surgical treatment for glaucoma after first eye trabeculectomy. DESIGN: Post hoc analysis of data collected in a multicenter, randomized clinical trial. METHODS: Data from participants in the Col ... Full text Link to item Cite

Glaucoma.

Journal Article Am Fam Physician · April 15, 2016 Glaucoma is a set of irreversible, progressive optic neuropathies that can lead to severe visual field loss and blindness. The two most common forms of glaucoma, primary open-angle glaucoma and primary angle-closure glaucoma, affect more than 2 million Ame ... Link to item Cite

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography.

Journal Article Quant Imaging Med Surg · April 2016 BACKGROUND: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. METHODS: One eye from each subj ... Full text Link to item Cite

Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography.

Journal Article PLoS One · 2016 PURPOSE: To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. DESIGN: Cro ... Full text Open Access Link to item Cite

Macular thickness analysis for glaucoma diagnosis and management.

Journal Article Taiwan J Ophthalmol · 2016 There is increasing literature regarding the role of macular imaging by optical coherence tomography (OCT) in glaucoma care. Spectral domain OCT (SD-OCT) has allowed for high resolution imaging of the total macula and macular segments. With the use of asym ... Full text Link to item Cite

Evidence in Ophthalmology: Are We Doing Better?

Journal Article Ophthalmology · December 2015 Full text Link to item Cite

Optic Disc Hemorrhages in Glaucoma

Journal Article Current Ophthalmology Reports · June 1, 2015 Optic disc hemorrhages are a significant clinical sign seen in patients with glaucoma and often herald glaucomatous progression. Longitudinal and population-based studies have shown that disc hemorrhages are most commonly seen in glaucoma, particularly nor ... Full text Cite

Effect of surgical case order on cataract surgery complication rates and procedure time.

Journal Article J Cataract Refract Surg · March 2015 PURPOSE: To determine whether surgical warm-up affects cataract surgery complication rates and surgical case times. SETTING: University of Washington Medicine Eye Institute, Harborview, Seattle, Washington, USA. DESIGN: Retrospective case-control study. ME ... Full text Link to item Cite

Orbital Metastasis of Undifferentiated/Anaplastic Thyroid Carcinoma.

Journal Article Ophthalmic Plast Reconstr Surg · 2015 A 52-year-old woman presented with decreased vision, diplopia, esotropia, proptosis, and right orbital pain. Clinical examination was suspicious for an orbital mass and additionally revealed a thyroid gland mass. Imaging studies showed an enhancing mass wi ... Full text Link to item Cite

Delayed Correction of Hypotony Maculopathy in a Patient with Glaucoma and Thyroid-Related Orbitopathy.

Journal Article Case Rep Ophthalmol · 2015 Hypotony maculopathy is a condition that may result in visual deterioration from choroidal folds or optic disc edema. Optic disc edema can result from altered translaminar pressure gradients (lowered intraocular pressure, increased cerebrospinal fluid pres ... Full text Open Access Link to item Cite

A case of nodular fasciitis causing compressive optic neuropathy.

Journal Article Ophthalmic Plast Reconstr Surg · 2014 A 16-year-old girl with worsening vision, new OD visual field deficits, and tumor in right orbital apex underwent biopsy and surgical excision. Orbital imaging revealed an apical tumor causing bony erosion. Histopathology confirmed the diagnosis of nodular ... Full text Link to item Cite

Orbital neoplasms in adults: clinical, radiologic, and pathologic review.

Journal Article Radiographics · October 2013 Orbital neoplasms in adults may be categorized on the basis of location and histologic type. Imaging features of these lesions often reflect their tissue composition. Cavernous malformations (also known as cavernous hemangiomas), although not true neoplasm ... Full text Link to item Cite

Relationship between eye shape and the risk for glaucoma

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Comparison of complication rates of porous anophthalmic orbital implants.

Journal Article Ophthalmic Surg Lasers Imaging · 2011 BACKGROUND AND OBJECTIVE: Porous anophthalmic orbital implants are used widely. This study evaluates risk factors for porous anophthalmic orbital implant complications and compares complication rates of hydroxyapatite, porous polyethylene, and polyglactin ... Full text Link to item Cite

G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis.

Journal Article Cell Metab · April 7, 2010 G(s)alpha, the G protein that mediates receptor-stimulated cAMP generation, has been implicated as a regulator of adipogenesis and adipose tissue function. Heterozygous G(s)alpha mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patient ... Full text Link to item Cite

Comparison of Complications From Porous Anophthalmic Orbital Implants

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.

Journal Article Cell Metab · June 2009 In Albright hereditary osteodystrophy, a monogenic obesity disorder linked to heterozygous mutations of G(s)alpha, the G protein that mediates receptor-stimulated cAMP generation, obesity develops only when the mutation is on the maternal allele. Likewise, ... Full text Link to item Cite

G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.

Journal Article Am J Physiol Cell Physiol · April 2009 The ubiquitously expressed G protein alpha-subunit G(s)alpha is required for receptor-stimulated intracellular cAMP responses and is an important regulator of energy and glucose metabolism. We have generated skeletal muscle-specific G(s)alpha-knockout (KO) ... Full text Link to item Cite

PENETRATING INJURY FROM PLASTIC AIRSOFT PELLET SHOWS BEAM-HARDENING ARTIFACT ON COMPUTER TOMOGRAPHY.

Journal Article Retin Cases Brief Rep PURPOSE: To describe a case of left eye corneal perforation, cataract, hyphema, and intraocular foreign body after airsoft pellet injury. METHODS: The authors reviewed the medical history and diagnostic imaging of a 12-year-old boy injured by a pellet from ... Full text Link to item Cite