Dhanesh Kumar Gupta
Professor of Anesthesiology
The overall theme of my research is the application of clinical pharmacology tools to the individualization of the care of high-risk surgical patients, especially those undergoing neurosurgical procedures. Current research focuses on creating pharmacokinetic-pharmacodynamic models to allow simulation of dose-concentration-effect relationships that will result in reduced toxicity while maximizing efficacy of intravenous opioids and hypnotics. The perioperative period is a time when patients are exposed to a multitude of drugs from a different classes, some of which may attenuate while others may augment the deleterious cascade of events that starts in the operating room and result in worse neuro-oncologic, neurovascular, or pain outcomes, even after the perioperative medication has been discontinued. Analytical techniques for perioperative “big data” have not been combined with the clinical pharmacology toolbox to create dose-response models that can help optimize perioperative care. Through collaboration with pharmacometricians and informaticians, care paths can be developed in an iterative fashion to expose the innards of the perioperative black box.
Current Appointments & Affiliations
- Professor of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2021
- Chief, Division of Neuro Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2015
Contact Information
- DUMC Box 3094, Durham, NC 27710
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dhanesh.gupta@duke.edu
(919) 681-2470
- Background
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Education, Training, & Certifications
- M.B.A., Duke University 2018
- Fellowship, Neuroanesthesia, University of California - San Francisco 2000 - 2001
- Residency, Anesthesiology, University of California - San Francisco 1997 - 2000
- Internship, Internal Medicine, Northwestern University, Feinberg School of Medicine 1996 - 1997
- M.D., Northwestern University, Feinberg School of Medicine 1996
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Previous Appointments & Affiliations
- Professor of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2015 - 2020
- Instructor Temporary in the Department of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2015
- Research
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Selected Grants
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Urick D, Sciavolino B, Wang TY, Gupta DK, Sharan A, Abd-El-Barr MM. Perioperative outcomes of general versus spinal anesthesia in the lumbar spine surgery population: A systematic review and meta-analysis of data from 2005 through 2021. J Clin Orthop Trauma. 2022 Jul;30:101923.Full Text Link to Item
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Browndyke JN, Wright MC, Yang R, Syed A, Park J, Hall A, et al. Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study. Br J Anaesth. 2021 Dec;127(6):917–28.Full Text Open Access Copy Link to Item
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Dalton T, Sykes D, Wang TY, Donnelly D, Than KD, Karikari IO, et al. Robotic-Assisted Trajectory Into Kambin's Triangle During Percutaneous Transforaminal Lumbar Interbody Fusion-Initial Case Series Investigating Safety and Efficacy. Oper Neurosurg (Hagerstown). 2021 Nov 15;21(6):400–8.Full Text Link to Item
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Wang TY, Price M, Mehta VA, Bergin SM, Sankey EW, Foster N, et al. Preoperative optimization for patients undergoing elective spine surgery. Clin Neurol Neurosurg. 2021 Mar;202:106445.Full Text Open Access Copy Link to Item
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Mehta VA, Van Belleghem F, Price M, Jaykel M, Ramirez L, Goodwin J, et al. Hematocrit as a predictor of preoperative transfusion-associated complications in spine surgery: A NSQIP study. Clin Neurol Neurosurg. 2021 Jan;200:106322.Full Text Open Access Copy Link to Item
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Nobuhara CK, Bullock WM, Bunning T, Colin B, Cooter M, Devinney MJ, et al. A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults. J Neurol. 2020 Jul;267(7):2002–6.Full Text Link to Item
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Wang TY, Mehta VA, Sankey EW, Than KD, Goodwin CR, Karikari IO, et al. Awake percutaneous transforaminal lumbar interbody fusion with expandable cage and robotic-assisted navigation and instrumentation: Case report and review of literature. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 2020 Jun 1;20.Full Text
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Berger M, Cooter M, Ni K, Thomas J, Gupta DK, Kertai MD. Response to 'Correlation between bispectral index and age-adjusted minimal alveolar concentration' (Br J Anaesth 2020; 124:e8). Br J Anaesth. 2020 Mar;124(3):e38–9.Full Text Link to Item
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Cooter M, Ni K, Thomas J, Gupta DK, Hopkins TJ, Miller TE, et al. Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis. Br J Anaesth. 2020 Jan;124(1):e4–7.Full Text Link to Item
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Johnson A, Rice AN, Titch JF, Gupta DK. Identifying Components Necessary for an Enhanced Recovery After Surgery Pathway for Elective Intracranial Surgery: An Improvement Project Using the Quality of Recovery-15 Score. World Neurosurg. 2019 Oct;130:e423–30.Full Text Link to Item
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Ni K, Cooter M, Gupta DK, Thomas J, Hopkins TJ, Miller TE, et al. Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values. Br J Anaesth. 2019 Sep;123(3):288–97.Full Text Link to Item
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Plyler SS, Muckler VC, Titch JF, Gupta DK, Rice AN. Low-Dose Ketamine Infusion to Decrease Postoperative Delirium for Spinal Fusion Patients. J Perianesth Nurs. 2019 Aug;34(4):779–88.Full Text Link to Item
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Hollis C, Rice AN, Gupta DK, Goode V. Laboratory Monitoring and Transfusion Guidelines to Influence Care in Patients Undergoing Multilevel Spinal Fusion Surgery. J Perianesth Nurs. 2019 Aug;34(4):691–700.Full Text Link to Item
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Wortham TC, Rice AN, Gupta DK, Goode V. Implementation of an Obstructive Sleep Apnea Protocol in the Postanesthesia Care Unit for Patients Undergoing Spinal Fusion Surgery. J Perianesth Nurs. 2019 Aug;34(4):739–48.Full Text Link to Item
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Revell CC, Rice AN, Gupta DK, Muckler VC. Implementation of Physiological Scoring to Determine Discharge Readiness for Patients Undergoing Otolaryngology Head and Neck Procedures. J Perianesth Nurs. 2019 Jun;34(3):529–38.Full Text Link to Item
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Carabini LM, Moreland NC, Vealey RJ, Bebawy JF, Koski TR, Koht A, et al. A Randomized Controlled Trial of Low-Dose Tranexamic Acid versus Placebo to Reduce Red Blood Cell Transfusion During Complex Multilevel Spine Fusion Surgery. World Neurosurg. 2018 Feb;110:e572–9.Full Text Link to Item
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Hartl S, Rice AN, Gupta DK, Goode V. Preprocedural Checklist for Magnetic Resonance Imaging Patients Undergoing General Anesthesia: A Process Improvement Plan to Enhance Reimbursement. Health Care Manag (Frederick). 2018;37(3):205–10.Full Text Open Access Copy Link to Item
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Giattino CM, Gardner JE, Sbahi FM, Roberts KC, Cooter M, Moretti E, et al. Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults. Front Syst Neurosci. 2017;11:24.Full Text Open Access Copy Link to Item
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Kofke WA, Armstead WM, Gupta DK, Smith M, Luke James ML. Update in Neuroanesthesia-An Anesthesiology Clinics Issue Affiliated with SNACC. Anesthesiol Clin. 2016 Sep;34(3):xv–xvii.Full Text Link to Item
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Gupta DK, Suthar N, Singh V, Bihari M, Kumar V, Verma KK, et al. Frequency and pattern of radiological and laboratory investigations in patients with mental illnesses: A study from North Rajasthan. Indian Journal of Psychiatry. 2016 Apr 1;58(2):183–9.Full Text
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Bebawy JF, Gupta DK. In Response. Anesth Analg. 2015 Nov;121(5):1399–400.Full Text Link to Item
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Massey MF, Gupta DK. The incidence of donor-site morbidity after transverse cervical artery vascularized lymph node transfers: the need for a lymphatic surgery national registry. Plast Reconstr Surg. 2015 May;135(5):939e-940e.Full Text Open Access Copy Link to Item
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Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Marymont JH, Shear T, et al. Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients. Anesthesiology. 2015 May;122(5):1112–22.Full Text Link to Item
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Larson MD, Gupta DK. Pupillary Reflex Dilation to Predict Movement: A Step Forward Toward Real-time Individualized Intravenous Anesthetics. Anesthesiology. 2015 May;122(5):961–3.Full Text Link to Item
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Bebawy JF, Houston CC, Kosky JL, Badri AM, Hemmer LB, Moreland NC, et al. Nicardipine is superior to esmolol for the management of postcraniotomy emergence hypertension: a randomized open-label study. Anesth Analg. 2015 Jan;120(1):186–92.Full Text Link to Item
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Carabini LM, Navarre WJ, Ault ML, Bebawy JF, Gupta DK. A comparison of hemoglobin measured by co-oximetry and central laboratory during major spine fusion surgery. Anesth Analg. 2015 Jan;120(1):60–5.Full Text Link to Item
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Zeeni C, Carabini LM, Gould RW, Bebawy JF, Hemmer LB, Moreland NC, et al. The implementation and efficacy of the Northwestern High Risk Spine Protocol. World Neurosurg. 2014 Dec;82(6):e815–23.Full Text Link to Item
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Carabini LM, Zeeni C, Moreland NC, Gould RW, Hemmer LB, Bebawy JF, et al. Predicting major adverse cardiac events in spine fusion patients: is the revised cardiac risk index sufficient? Spine (Phila Pa 1976). 2014 Aug 1;39(17):1441–8.Full Text Link to Item
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Carabini LM, Zeeni C, Moreland NC, Gould RW, Avram MJ, Hemmer LB, et al. Development and validation of a generalizable model for predicting major transfusion during spine fusion surgery. J Neurosurg Anesthesiol. 2014 Jul;26(3):205–15.Full Text Link to Item
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Cambic CR, Avram MJ, Gupta DK, Wong CA. Effect of ritonavir-induced cytochrome P450 3A4 inhibition on plasma fentanyl concentrations during patient-controlled epidural labor analgesia: a pharmacokinetic simulation. Int J Obstet Anesth. 2014 Feb;23(1):45–51.Full Text Open Access Copy Link to Item
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Hemmer LB, Zeeni C, Bebawy JF, Bendok BR, Cotton MA, Shah NB, et al. The incidence of unacceptable movement with motor evoked potentials during craniotomy for aneurysm clipping. World Neurosurg. 2014 Jan;81(1):99–104.Full Text Open Access Copy Link to Item
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Bebawy JF, Zeeni C, Sharma S, Kim ES, DeWood MS, Hemmer LB, et al. Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation does not worsen neurologic outcome. Anesth Analg. 2013 Nov;117(5):1205–10.Full Text Link to Item
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Gupta DK, Huang S-M. Drug shortages in the United States: a critical evaluation of root causes and the need for action. Clin Pharmacol Ther. 2013 Feb;93(2):133–5.Full Text Link to Item
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Bebawy JF, Ramaiah VK, Zeeni C, Hemmer LB, Koht A, Gupta DK. The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis. J Neurosurg Anesthesiol. 2013 Jan;25(1):51–4.Full Text Link to Item
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Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Marymont JH, Vender JS, et al. In reply. Anesthesiology. 2012 Jun 1;116(6):1396–7.Full Text
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Gupta DK, Avram MJ. Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy. Clin Pharmacol Ther. 2012 Feb;91(2):339–43.Full Text Link to Item
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Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Marymont JH, Vender JS, et al. Intraoperative acceleromyography monitoring reduces symptoms of muscle weakness and improves quality of recovery in the early postoperative period. Survey of Anesthesiology. 2012;56:150–1.
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Bebawy JF, Ramaiah VK, Hemmer LB, Gupta DK. Clinical pharmacology of insulin confounds stroke trials. Ann Neurol. 2012 Jan;71(1):148.Full Text Link to Item
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Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Marymont JH, Vender JS, et al. Intraoperative acceleromyography monitoring reduces symptoms of muscle weakness and improves quality of recovery in the early postoperative period. Anesthesiology. 2011 Nov;115(5):946–54.Full Text Link to Item
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Bendok BR, Gupta DK, Rahme RJ, Eddleman CS, Adel JG, Sherma AK, et al. Adenosine for temporary flow arrest during intracranial aneurysm surgery: a single-center retrospective review. Neurosurgery. 2011 Oct;69(4):815–20.Full Text Link to Item
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Rahme RJ, Adel JG, Bendok BR, Bebawy JF, Gupta DK, Batjer HH. Association of intracranial aneurysm and Loeys-Dietz syndrome: case illustration, management, and literature review. Neurosurgery. 2011 Aug;69(2):E488–92.Full Text Link to Item
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Bebawy JF, Gupta DK, Koht A. Compartment syndrome caused by a properly functioning infusion pump. J Clin Anesth. 2011 Mar;23(2):134–6.Full Text Link to Item
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Zeeni C, Bebawy JF, Gupta DK, Koht A. Open Surgical Approaches. Hemorrhagic and Ischemic Stroke: Medical, Imaging, Surgical and Interventional Approaches. 2011;
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Hemmer LB, Zeeni C, Gupta DK. Generalizations about general anesthesia: the unsubstantiated condemnation of general anesthesia for patients undergoing intra-arterial therapy for anterior circulation stroke. Stroke. 2010 Oct;41(10):e573.Full Text Link to Item
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Johnson KB, Syroid ND, Gupta DK, Manyam SC, Pace NL, LaPierre CD, et al. An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. Anesth Analg. 2010 Aug;111(2):387–94.Full Text Open Access Copy Link to Item
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Nguyen HP, Zaroff JG, Bayman EO, Gelb AW, Todd MM, Hindman BJ, et al. Perioperative hypothermia (33 degrees C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. Anesthesiology. 2010 Aug;113(2):327–42.Full Text Link to Item
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Bebawy JF, Gupta DK, Bendok BR, Hemmer LB, Zeeni C, Avram MJ, et al. Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. Anesth Analg. 2010 May 1;110(5):1406–11.Full Text Open Access Copy Link to Item
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Bebawy JF, Gupta DK, Cotton MA, Gil KS, Fohrman EB, Mirkovic S, et al. Alternative anterior reference sites for measuring posterior tibial nerve somatosensory evoked potentials. J Clin Monit Comput. 2010 Apr;24(2):107–11.Full Text Link to Item
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Bebawy JF, Gupta DK, Bendok BR, Hemmer LB, Zeeni C, Avram MJ, et al. NEUROSCIENCE IN ANESTHESIOLOGY AND PERIOPERATIVE MEDICINE-Adenosine-Induced Flow Arrest to Facilitate Intracranial Aneurysm Clip Ligation: Dose-Response Data and Safety Profile. Anesthesia and Analgesia. 2010;110:1406–1406.
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Bendok BR, Rahme R, Gupta DK, Eddleman CS, Adel JG, Sherma A, et al. Adenosine for Temporary Flow Arrest During Intracranial Aneurysm Surgery: A Single Center Retrospective Review: 920. Neurosurgery. 2010;67:542–542.
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Carabini LM, Zeeni C, Gould RW, Bebawy JF, Gupta DK. The Impact of the Active Management of Coagulation during Spinal Fusion on Extubation Times. 2010;
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Gupta DK, Bebawy JF. How Likely Do Common Propofol-Remifentanil Doses Achieve Adequate Induction of Anesthesia? 2010;
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Zeeni C, Carabini LM, Gould RW, Bebawy JF, Gupta DK. The Active Management of Coagulation Decreases Transfusion and Coagulopathy during Spinal Fusion. 2010;
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Hindman BJ, Bayman EO, Pfisterer WK, Torner JC, Todd MM, IHAST Investigators. No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. Anesthesiology. 2010 Jan;112(1):86–101.Full Text Link to Item
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Todd MM, Hindman BJ, Clarke WR, Torner JC, Weeks JB, Bayman EO, et al. Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage. Neurosurgery. 2009 May;64(5):897–908.Full Text Link to Item
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Zeeni C, Hemmer LB, Gupta DK, Koht A. Determining the remifentanil dose-response relationship during craniotomies: the importance of intensity of the stimulus at the time of pharmacodynamic evaluation. J Neurosurg Anesthesiol. 2009 Apr;21(2):179.Full Text Link to Item
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Pasternak JJ, McGregor DG, Lanier WL, Schroeder DR, Rusy DA, Hindman B, et al. Effect of nitrous oxide use on long-term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery. Anesthesiology. 2009 Mar;110(3):563–73.Full Text Link to Item
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Avram MJ, Gupta DK, Atkinson AJ. Corrigendum: Editorial (Clinical Pharmacology Therapeutics (2008) 84, (3-6) DOI: 10.1038/clpt.2008.99). Clinical Pharmacology and Therapeutics. 2008 Sep 1;84(3):430.Full Text
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Avram MJ, Gupta DK, Atkinson AJ. Anesthesia: a discipline that incorporates clinical pharmacology across the DDRU continuum. Clin Pharmacol Ther. 2008 Jul;84(1):3–6.Full Text Link to Item
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Gupta DK, Eger EI. Inhaled anesthesia: the original closed-loop drug administration paradigm. Clin Pharmacol Ther. 2008 Jul;84(1):15–8.Full Text Link to Item
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Gupta DK. Processed EEG (bispectral index) is not appropriate for characterizing opioid sedation. Clin Pharmacol Ther. 2008 May;83(5):667–8.Full Text Link to Item
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Johnson KB, Syroid ND, Gupta DK, Manyam SC, Egan TD, Huntington J, et al. An evaluation of remifentanil propofol response surfaces for loss of responsiveness, loss of response to surrogates of painful stimuli and laryngoscopy in patients undergoing elective surgery. Anesth Analg. 2008 Feb;106(2):471–9.Full Text Link to Item
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Gupta DK, Manyam SC, Johnson KB, Westenskow DR, Egan TD. Rationale Volatile Anesthetic Opioid Selection Based on Pharmacokinetic-Pharmacodynamic Optimization. Anesthesiology. 2008;109:A689–A689.
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Surdell DL, Hage ZA, Eddleman CS, Gupta DK, Bendok BR, Batjer HH. Revascularization for complex intracranial aneurysms. Neurosurg Focus. 2008;24(2):E21.Full Text Link to Item
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Avram MJ, Gupta DK, Atkinson Jr AJ. Untitled (vol 84, pg 3, 2008). Clinical Pharmacology & Therapeutics. 2008;84:430–430.
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Johnson KB, Syroid ND, Gupta DK, Manyam S, Egan TD, Huntington J, et al. Validation of remifentanil propofol response surfaces for sedation, surrogates of surgical stimulus, and laryngoscopy in patients undergoing surgery. Anesthesia and Analgesia. 2008;106:471–471.
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Cole CD, Gottfried ON, Gupta DK, Couldwell WT. Total intravenous anesthesia: advantages for intracranial surgery. Neurosurgery. 2007 Nov;61(5 Suppl 2):369–77.Full Text Link to Item
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Massey MF, Gupta DK. The effects of systemic phenylephrine and epinephrine on pedicle artery and microvascular perfusion in a pig model of myoadipocutaneous rotational flaps. Plast Reconstr Surg. 2007 Oct;120(5):1289–99.Full Text Link to Item
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Manyam SC, Gupta DK, Johnson KB, White JL, Pace NL, Westenskow DR, et al. When is a bispectral index of 60 too low?: Rational processed electroencephalographic targets are dependent on the sedative-opioid ratio. Anesthesiology. 2007 Mar;106(3):472–83.Full Text Link to Item
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Gupta D, Manyam S, Johnson K, Egan T. Can 1% Sevoflurane with 5 ng/ml Remifentanil Prevent Implicit Memory? Anesthesiology Hagerstown. 2007;107:1031–1031.
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Manyam SC, Gupta DK, Johnson KB, White JL, Pace NL, Westenskow DR, et al. Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. Anesthesiology. 2006 Aug;105(2):267–78.Full Text Link to Item
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Gupta DK, Bruen KJ, Massey MF. The Effects of Isoflurane and Propofol on Free Flap Ischemia-Reperfusion Injury–A Genomic Analysis. Anesthesiology. 2006;105:A1093–A1093.
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Gupta DK, Manyam SC, BE KBJ, White JL, Egan TD. Does the" Ideal" Combination of Remifentanil and Propofol Change with Duration of Surgery? Anesthesiology. 2006;105:A1199–A1199.
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Manyam SC, Gupta DK, White JL, others. Levels of Sedation Produced by the Addition of Remifentanil to Sevoflurane Are Not Reflected by BIS. Anesthesiology. 2006;105:A856–A856.
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Ko NU, Achrol AS, Chopra M, Saha M, Gupta D, Smith WS, et al. Cerebral blood flow changes after endovascular treatment of cerebrovascular stenoses. Ajnr Am J Neuroradiol. 2005 Mar;26(3):538–42.Link to Item
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Gupta DK, Massey MF. The Role of Sympathetic Innervation in the Control of Microvascular Perfusion in Myocutaneous Flaps. Anesthesiology. 2005;103:A537–A537.
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Tewari P, Gupta D, Kumar A, Singh U. Opioid sparing during endotracheal intubation using McCoy laryngoscope in neurosurgical patients: the comparison of haemodynamic changes with Macintosh blade in a randomized trial. J Postgrad Med. 2005;51(4):260–4.Link to Item
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Gupta DK, Manyam SC, Johnson KB, Pace NL, Stat M, Egan TD. Do Opioids Influence the Depth of Sedation Produced by Sedative/Hypnotics? An Observational Study of the Interaction between Remifentanil and Sevoflurane or Propofol as Measured by OAAS, BIS, and AEP. Anesthesiology. 2004;101:A477–A477.
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Gupta DK, Massey MF. The Effects of Phenylephrine and Epinephrine on Myocutaneous Rotational and Free Flap Microvascular Perfusion. Anesthesiology. 2004;101:A658–A658.
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Gupta DK, Manyam SC, Johnson KB, White JL, Egan TD. The Auditory Evoked Potential and the Bispectral Index™: A Comparison of Signal Performance during Clinically Inadequate Anesthesia. Anesthesiology. 2003;99.
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Gupta DK, Massey MF, Siddiqi FA, McJames SW, Cluff M. The Effects of Phenylephrine and Nitroprusside on Rotational Flap Blood Flow. Anesthesiology. 2003;99:A631–A631.
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Hashimoto T, Young WL, Prohovnik I, Gupta DK, Ostapkovich ND, Ornstein E, et al. Increased cerebral blood flow after brain arteriovenous malformation resection is substantially independent of changes in cardiac output. J Neurosurg Anesthesiol. 2002 Jul;14(3):204–8.Full Text Link to Item
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Hashimoto T, Gupta DK, Young WL. Interventional neuroradiology--anesthetic considerations. Anesthesiol Clin North Am. 2002 Jun;20(2):347–vi.Full Text Link to Item
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Gupta DK, Young WL, Hashimoto T, Halim AX, Marshall RS, Lazar RM, et al. Characterization of the cerebral blood flow response to balloon deflation after temporary internal carotid artery test occlusion. J Neurosurg Anesthesiol. 2002 Apr;14(2):123–9.Full Text Link to Item
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Young WL, Lawton MT, Gupta DK, Hashimoto T. Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping. Anesthesiology. 2002 Feb;96(2):497–503.Full Text Link to Item
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Gupta DK, Young WL, Higashida RT, Caragine LP, Lefler JE. The Effect of Nitric Oxide Synthase Inhibition on Hyperemia Following Transluminal Cerebral Angioplasty. Anesthesiology. 2001;95:A309–A309.
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Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, et al. Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly. J Pharmacol Exp Ther. 1996 Sep;278(3):1050–7.Link to Item
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KREJCIE T, HENTHORN TK, NIEMANN CU, KLEIN C, GUPTA DK. Extracellular Fluid and Total Body Water Administered Concomitantly1. The Journal (If Pharmac0l0 (; Y An!). 1996;278.
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Gentry WB, Krejcie TC, Henthorn TK, Shanks CA, Howard KA, Gupta DK, et al. Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model. Anesthesiology. 1994 Aug;81(2):316–24.Link to Item
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Book Sections
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Gupta DK, Henthorn TK. Principles of pharmacokinetics and pharmacodynamics. In: Clinical Anesthesia Fundamentals. 2015.
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Gupta DK, Henthorn TK. Principles of clinical pharmacology. In: Clinical Anesthesia: Seventh Edition. 2013.
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Hemmer LB, Zeeni C, Gupta DK. Intracranial AVM surgery. In: Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals. Springer US; 2012. p. 393–406.
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Zeeni C, Hemmer LB, Gupta DK, Bendok B, Koht A. Intracranial Aneurysm Clipping. In: Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals. Springer US; 2012. p. 373–91.
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Other Articles
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Bendok BR, El Tecle N, El Ahmadieh TY, Bebawy JF, Gupta DK, Hemmer LB, et al. Surgical Treatment of 127 Anterior Choroidal Artery Aneurysms: A Cohort Study of Resultant Ischemic Complications COMMENT. LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA; 2013.
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Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Marymont JH, Vender JS, et al. A Train-of-Four Count Should Be a Train-of-Four Count, Independently of the Method It Was Determined With Reply. Vol. 116, Anesthesiology. LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA; 2012. p. 1396–7.
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GUPTA D, HENTHORN T. ASSOCIATION OF UNIVERSITY ANESTHESIOLOGISTS SATELLITE SYMPOSIUM-PHARMACOKINETICS AND PHARMACODYNAMICS. LIPPINCOTT-RAVEN PUBL 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106; 1994.
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Conference Papers
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Willie C, Moreland N, McNicholas E, Hemmer LB, Bebawy JF, Gupta DK. DOES REMIFENTANIL IMPROVE HEMODYNAMIC STABILITY DURING PLACEMENT OF A MAYFIELD HEAD FIXATION DEVICE COMPARED TO PROPOFOL ALONE? A RANDOMIZED, PLACEBO-CONTROLLED DOUBLE-BLINDED COMPARATIVE EFFECTIVENESS STUDY. In: Anesthesia and Analgesia. 2013. p. 158–158.
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Gupta DK, Cambic CR, Wong CA, Avram MJ. THE INTERACTION BETWEEN RITONAVIR AND EPIDURALLY ADMINISTERED FENTANYL DURING LABOR ANALGESIA-A SIMULATION STUDY. In: Clinical Pharmacology & Therapeutics. 2010. p. S59–S59.
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Gupta DK, King B, Rampil IJ. The effects of thiopental on spinal motor neurons. In: Anesthesia and Analgesia. 2000. p. U244–U244.
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Gentry WB, Henthorn TK, Krejcie TC, Gupta DK, Shanks CA, Avram MJ. RECIRCULATORY KINETICS OF MARKERS OF BLOOD, INTERSTITIAL FLUID, AND TOTAL-BODY WATER ADMINISTERED CONCOMITANTLY. In: Anesthesiology. 1993. p. A338–A338.
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Gentry WB, Krejcie TC, Henthorn TK, Shanks CA, Gupta DK, Avram MJ. INFUSION RATE-RELATED THIOPENTAL DOSE-RESPONSE-APPLICATION OF A KINETIC-DYNAMIC MODEL. In: Anesthesiology. 1993. p. A339–A339.
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Henthorn TK, Krejcie TC, Gentry WB, Gupta DK, Avram MJ. Inclusion of pulmonary uptake in a recirculatory model of lidocaine. In: Anesthesiology. 1993. p. A340–A340.
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Gentry WB, KREJCIE T, HENTHORN T, HOWARD K, GUPTA D, SHANKS C, et al. Thiopental dose requirements with different rates of infusion. In: Clinical Pharmacology & Therapeutics. 1993. p. 218–218.
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Henthorn TK, Krejcie TC, Gupta DK, Shanks CA, Gentry WB, Avram MJ. Recirculatory kinetics of ICG, inulin, and antipyrine. In: Clinical Pharmacology & Therapeutics. 1993. p. 217–217.
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- Teaching & Mentoring
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Advising & Mentoring
Available to mentor:
- Faculty
- Fellow
- Masters
- Other
- PhD
- Post-Doc
- Resident
- Undergraduate
- Scholarly, Clinical, & Service Activities
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Service to the Profession
- At Large Member of Board of Directors. Society for Neuroscience in Anesthesia & Critical Care . October 2014 - October 2017 2014 - 2017
- Chair. Abstract Review Subcommittee on Anesthetic Action & Biochemistry. American Society of Anesthesiologists. October 2012 - October 2015 2012 - 2015
- Vice Chair. Abstract Review Subcommittee on Drug Dispostion, Metabolism, and Elimination. American Society of Anesthesiologists. October 2012 - October 2015 2012 - 2015
- At Large Member of Board of Directors. American Society of Clinical Pharmacology & Therapeutics. March 2011 - March 2014 2011 - 2014
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