Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Liverpool (United Kingdom) 1969
• 

  Previous Appointments & Affiliations

  • Professor of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 2006 - 2015
  • Research Professor of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 1998 - 2006
  • Associate Research Professor of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 1997 - 1998
  • Associate Research Professor of Pediatrics, Pediatrics, Clinical Science Departments 1994 - 1997
• Research
• 

  Selected Grants

  • Gender and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2019 - 2024
  • Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia awarded by National Institutes of Health 2011 - 2018
  • Dietary therapy in mitochondrial trifunctional protein deficiency awarded by Ultragenyx Pharmaceutical 2014 - 2015
  • Development and validation of a UPLC-MS/MS assay for urinary keratan sulfate (uKS) awarded by BioMarin Pharmaceutical, Inc. 2013 - 2015
  • Lab on a Chip for Multiplexed Newborn Screening of Lysosomal Storage Disease awarded by Baebies, Inc 2009 - 2015
  • Multidisciplinary Neonatal Training Grant awarded by National Institutes of Health 2010 - 2015
  • Adoptive Immunotherapy for GBM During Hematopoietic Recovery from Temozolomide awarded by National Institutes of Health 2009 - 2014
  • Training course for expanded (MS/MS) newborn screening laboratory follow-up coordinators awarded by Association of Public Health Laboratories 2014
  • Urinary F2-isoprostanes as a new biomarker for the risk of type 2 diabetes awarded by National Institutes of Health 2009 - 2013
  • Pharmacometabolomics Research Network awarded by National Institutes of Health 2010 - 2011
  • Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health 2003 - 2009
  • Metabolic Profiling to Identify Alcohol Biomarker Signature awarded by National Institutes of Health 2006 - 2009
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Millington, David S., and Can Ficicioglu. “Addition of MPS-II to the Recommended Uniform Screening Panel in the United States.” Int J Neonatal Screen 8, no. 4 (October 11, 2022). https://doi.org/10.3390/ijns8040055.
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    • Millington, David S. “The Editor's Choice for Issue 4, Volume 7.” Int J Neonatal Screen 8, no. 1 (March 16, 2022). https://doi.org/10.3390/ijns8010021.
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    • Padilla, Carmencita D., Bradford L. Therrell, Maria Melanie Liberty B. Alcausin, Mary Anne D. Chiong, Mary Ann R. Abacan, Ma Elouisa L. Reyes, Charity M. Jomento, et al. “Successful Implementation of Expanded Newborn Screening in the Philippines Using Tandem Mass Spectrometry.” Int J Neonatal Screen 8, no. 1 (January 19, 2022). https://doi.org/10.3390/ijns8010008.
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    • Millington, David S. “The Editor's Choice for Issue 1, Volume 7.” Int J Neonatal Screen 7, no. 2 (June 18, 2021). https://doi.org/10.3390/ijns7020031.
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    • Adams, Kendra J., Joan G. Wilson, David S. Millington, M Arthur Moseley, Carol A. Colton, J Will Thompson, and W Kirby Gottschalk. “Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models.” J Am Soc Mass Spectrom 32, no. 6 (June 2, 2021): 1448–58. https://doi.org/10.1021/jasms.1c00055.
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    • Washburn, Jon, and David S. Millington. “Digital Microfluidics in Newborn Screening for Mucopolysaccharidoses: A Progress Report.” Int J Neonatal Screen 6, no. 4 (October 8, 2020). https://doi.org/10.3390/ijns6040078.
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    • Zhang, Haoyue, Patricia I. Dickson, Ashlee R. Stiles, Agnes H. Chen, Steven Q. Le, Patricia McCaw, James Beasley, David S. Millington, and Sarah P. Young. “Comparison of dermatan sulfate and heparan sulfate concentrations in serum, cerebrospinal fluid and urine in patients with mucopolysaccharidosis type I receiving intravenous and intrathecal enzyme replacement therapy.” Clin Chim Acta 508 (September 2020): 179–84. https://doi.org/10.1016/j.cca.2020.05.035.
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    • Ahmed, Ahmed T., Siamak MahmoudianDehkordi, Sudeepa Bhattacharyya, Matthias Arnold, Duan Liu, Drew Neavin, M Arthur Moseley, et al. “Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes.” J Affect Disord 264 (March 1, 2020): 90–97. https://doi.org/10.1016/j.jad.2019.11.122.
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    • Lee, Stacey, Kristin Clinard, Sarah P. Young, Catherine W. Rehder, Zheng Fan, Ali S. Calikoglu, Deeksha S. Bali, et al. “Evaluation of X-Linked Adrenoleukodystrophy Newborn Screening in North Carolina.” Jama Netw Open 3, no. 1 (January 3, 2020): e1920356. https://doi.org/10.1001/jamanetworkopen.2019.20356.
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    • Yeo, Tsin W., Peggy A. Bush, Youwei Chen, Sarah P. Young, Haoyue Zhang, David S. Millington, Donald L. Granger, Esther D. Mwaikambo, Nicholas M. Anstey, and J Brice Weinberg. “Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria.” Faseb J 33, no. 12 (December 2019): 14185–93. https://doi.org/10.1096/fj.201901048RR.
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    • Yeo, Tsin W., J Brice Weinberg, Daniel A. Lampah, Enny Kenangalem, Peggy Bush, Youwei Chen, Richard N. Price, et al. “Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria.” Clin Infect Dis 69, no. 10 (October 30, 2019): 1712–20. https://doi.org/10.1093/cid/ciz038.
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    • Taylor, Jennifer L., Kristin Clinard, Cynthia M. Powell, Catherine Rehder, Sarah P. Young, Deeksha Bali, Sara E. Beckloff, et al. “The North Carolina Experience with Mucopolysaccharidosis Type I Newborn Screening.” J Pediatr 211 (August 2019): 193-200.e2. https://doi.org/10.1016/j.jpeds.2019.04.027.
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    • Rubach, Matthew P., Haoyue Zhang, Salvatore M. Florence, Jackson P. Mukemba, Ayam R. Kalingonji, Nicholas M. Anstey, Tsin W. Yeo, et al. “Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria.” Infect Immun 87, no. 4 (April 2019). https://doi.org/10.1128/IAI.00655-18.
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    • Millington, David S. “The Role of Technology in Newborn Screening.” N C Med J 80, no. 1 (2019): 49–53. https://doi.org/10.18043/ncm.80.1.49.
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    • Millington, David S., and Deeksha S. Bali. “Current State of the Art of Newborn Screening for Lysosomal Storage Disorders.” Int J Neonatal Screen 4, no. 3 (September 2018): 24. https://doi.org/10.3390/ijns4030024.
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    • Nasca, Carla, Benedetta Bigio, Francis S. Lee, Sarah P. Young, Marin M. Kautz, Ashly Albright, James Beasley, et al. “Acetyl-l-carnitine deficiency in patients with major depressive disorder.” Proc Natl Acad Sci U S A 115, no. 34 (August 21, 2018): 8627–32. https://doi.org/10.1073/pnas.1801609115.
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    • Millington, David, Scott Norton, Raj Singh, Rama Sista, Vijay Srinivasan, and Vamsee Pamula. “Digital microfluidics comes of age: high-throughput screening to bedside diagnostic testing for genetic disorders in newborns.” Expert Rev Mol Diagn 18, no. 8 (August 2018): 701–12. https://doi.org/10.1080/14737159.2018.1495076.
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    • Pomerantz, Daniel J., Sacha Ferdinandusse, Joy Cogan, David N. Cooper, Tyler Reimschisel, Amy Robertson, Anna Bican, et al. “Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant.” Am J Med Genet A 176, no. 3 (March 2018): 692–98. https://doi.org/10.1002/ajmg.a.38602.
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    • Millington, David S. “Response to Gelb et al.: "Comparison of tandem mass spectrometry to fluorimetry for newborn screening of LSDs".” Mol Genet Metab Rep 12 (September 2017): 98. https://doi.org/10.1016/j.ymgmr.2017.06.008.
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    • Millington, David S., and Deeksha M. Bali. “Misinformation regarding tandem mass spectrometric vs fluorometric assays to screen newborns for LSDs.” Mol Genet Metab Rep 11 (June 2017): 72–73. https://doi.org/10.1016/j.ymgmr.2017.04.009.
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    • Peake, Roy W. A., Deborah L. Marsden, Olaf A. Bodamer, Michael H. Gelb, David S. Millington, and Frits Wijburg. “Newborn Screening for Lysosomal Storage Disorders: Quo Vadis?” Clin Chem 62, no. 11 (November 2016): 1430–38. https://doi.org/10.1373/clinchem.2016.258459.
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    • Sampat, Radhika, Sarah Young, Ami Rosen, Douglas Bernhard, David Millington, Stewart Factor, and H. A. Jinnah. “Potential mechanisms for low uric acid in Parkinson disease.” J Neural Transm (Vienna) 123, no. 4 (April 2016): 365–70. https://doi.org/10.1007/s00702-015-1503-4.
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    • Ledford, Cameron K., Robert J. Butler, Robin M. Queen, and Michael P. Bolognesi. “In reply.” J Arthroplasty 30, no. 5 (May 2015): 896. https://doi.org/10.1016/j.arth.2014.10.030.
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    • Zhang, Haoyue, Tim Wood, Sarah P. Young, and David S. Millington. “A straightforward, quantitative ultra-performance liquid chromatography-tandem mass spectrometric method for heparan sulfate, dermatan sulfate and chondroitin sulfate in urine: an improved clinical screening test for the mucopolysaccharidoses.” Mol Genet Metab 114, no. 2 (February 2015): 123–28. https://doi.org/10.1016/j.ymgme.2014.09.009.
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    • Houten, Sander M., Simone Denis, Heleen Te Brinke, Aldo Jongejan, Antoine H. C. van Kampen, Edward J. Bradley, Frank Baas, et al. “Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.” Hum Mol Genet 23, no. 18 (September 15, 2014): 5009–16. https://doi.org/10.1093/hmg/ddu218.
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    • Ullal, Anirudh J., David S. Millington, and Deeksha S. Bali. “Development of a fluorometric microtiter plate based enzyme assay for MPS IVA (Morquio type A) using dried blood spots.” Mol Genet Metab Rep 1 (2014): 461–64. https://doi.org/10.1016/j.ymgmr.2014.10.004.
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    • Ullal, Anirudh J., David S. Millington, and Deeksha S. Bali. “Development of a fluorometric microtiter plate-based enzyme assay for arylsulfatase B (MPS VI) using dried blood spots.” Mol Genet Metab Rep 1 (2014): 465–67. https://doi.org/10.1016/j.ymgmr.2014.10.005.
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    • Graham, Carrie, Ramakrishna S. Sista, Jairus Kleinert, Ning Wu, Allen Eckhardt, Deeksha Bali, David S. Millington, and Vamsee K. Pamula. “Novel application of digital microfluidics for the detection of biotinidase deficiency in newborns.” Clin Biochem 46, no. 18 (December 2013): 1889–91. https://doi.org/10.1016/j.clinbiochem.2013.09.003.
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    • Sista, Ramakrishna S., Tong Wang, Ning Wu, Carrie Graham, Allen Eckhardt, Theodore Winger, Vijay Srinivasan, Deeksha Bali, David S. Millington, and Vamsee K. Pamula. “Multiplex newborn screening for Pompe, Fabry, Hunter, Gaucher, and Hurler diseases using a digital microfluidic platform.” Clin Chim Acta 424 (September 23, 2013): 12–18. https://doi.org/10.1016/j.cca.2013.05.001.
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    • El-Gharbawy, Areeg H., Jennifer L. Goldstein, David S. Millington, Amie E. Vaisnins, Andrea Schlune, Bruce A. Barshop, Andreas Schulze, Dwight D. Koeberl, and Sarah P. Young. “Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency.” Mol Genet Metab 109, no. 2 (June 2013): 215–17. https://doi.org/10.1016/j.ymgme.2013.03.003.
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    • Sista, Ramakrishna S., Tong Wang, Ning Wu, Carrie Graham, Allen Eckhardt, Deeksha Bali, David S. Millington, and Vamsee K. Pamula. “Rapid assays for Gaucher and Hurler diseases in dried blood spots using digital microfluidics.” Mol Genet Metab 109, no. 2 (June 2013): 218–20. https://doi.org/10.1016/j.ymgme.2013.03.010.
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    • Zhang, Haoyue, Sarah P. Young, and David S. Millington. “Quantification of glycosaminoglycans in urine by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry.” Curr Protoc Hum Genet Chapter 17 (2013): Unit-17.12. https://doi.org/10.1002/0471142905.hg1712s76.
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    • Tolun, Adviye A., Peter M. Scarbrough, Haoyue Zhang, Jane-Ann McKillop, Frances Wang, Priya S. Kishnani, David S. Millington, Sarah P. Young, and Dora Il’yasova. “Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome.” Ann Epidemiol 22, no. 12 (December 2012): 892–94. https://doi.org/10.1016/j.annepidem.2012.09.005.
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    • Thompson, J Will, Haoyue Zhang, Peter Smith, Steven Hillman, M Arthur Moseley, and David S. Millington. “Extraction and analysis of carnitine and acylcarnitines by electrospray ionization tandem mass spectrometry directly from dried blood and plasma spots using a novel autosampler.” Rapid Commun Mass Spectrom 26, no. 21 (November 15, 2012): 2548–54. https://doi.org/10.1002/rcm.6370.
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    • Young, S. P., H. Zhang, T. Wood, H. Fu, C. Auray-Blais, D. D. Koeberl, and D. S. Millington. “QUANTIFICATION OF GLYCOSAMINOGLYCANS IN HUMAN URINE AND MOUSE TISSUE BY UPLC-MS/MS.” Journal of Inherited Metabolic Disease 35 (September 1, 2012): S88–S88.
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    • Clark, Paul J., Alexander J. Thompson, David M. Vock, Lisa E. Kratz, Adviye A. Tolun, Andrew J. Muir, John G. McHutchison, et al. “Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner.” Hepatology 56, no. 1 (July 2012): 49–56. https://doi.org/10.1002/hep.25631.
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    • Auray-Blais, Christiane, Pamela Lavoie, Haoyue Zhang, René Gagnon, Joe T. R. Clarke, Bruno Maranda, Sarah P. Young, Yan An, and David S. Millington. “An improved method for glycosaminoglycan analysis by LC-MS/MS of urine samples collected on filter paper.” Clin Chim Acta 413, no. 7–8 (April 11, 2012): 771–78. https://doi.org/10.1016/j.cca.2012.01.012.
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    • Tolun, Adviye A., Carrie Graham, Qun Shi, Ramakrishna S. Sista, Tong Wang, Allen E. Eckhardt, Vamsee K. Pamula, David S. Millington, and Deeksha S. Bali. “A novel fluorometric enzyme analysis method for Hunter syndrome using dried blood spots.” Mol Genet Metab 105, no. 3 (March 2012): 519–21. https://doi.org/10.1016/j.ymgme.2011.12.011.
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    • Young, Sarah P., Monique Piraud, Jennifer L. Goldstein, Haoyue Zhang, Catherine Rehder, Pascal Laforet, Priya S. Kishnani, David S. Millington, Mustafa R. Bashir, and Deeksha S. Bali. “Assessing disease severity in Pompe disease: the roles of a urinary glucose tetrasaccharide biomarker and imaging techniques.” Am J Med Genet C Semin Med Genet 160C, no. 1 (February 15, 2012): 50–58. https://doi.org/10.1002/ajmg.c.31320.
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    • Il’yasova, Dora, Ivan Spasojevic, Karel Base, Haoyue Zhang, Frances Wang, Sarah P. Young, David S. Millington, Ralph B. D’Agostino, and Lynne E. Wagenknecht. “Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes.” Diabetes Care 35, no. 1 (January 2012): 173–74. https://doi.org/10.2337/dc11-1502.
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    • Sista, Ramakrishna S., Allen E. Eckhardt, Tong Wang, Carrie Graham, Jeremy L. Rouse, Scott M. Norton, Vijay Srinivasan, et al. “Digital microfluidic platform for multiplexing enzyme assays: implications for lysosomal storage disease screening in newborns.” Clin Chem 57, no. 10 (October 2011): 1444–51. https://doi.org/10.1373/clinchem.2011.163139.
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    • Zhang, Haoyue, Sarah P. Young, Christiane Auray-Blais, Paul J. Orchard, Jakub Tolar, and David S. Millington. “Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry.” Clin Chem 57, no. 7 (July 2011): 1005–12. https://doi.org/10.1373/clinchem.2010.161141.
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    • Auray-Blais, Christiane, Patrick Bhérer, René Gagnon, Sarah P. Young, Haoyue H. Zhang, Yan An, Joe T. R. Clarke, and David S. Millington. “Efficient analysis of urinary glycosaminoglycans by LC-MS/MS in mucopolysaccharidoses type I, II and VI.” Mol Genet Metab 102, no. 1 (January 2011): 49–56. https://doi.org/10.1016/j.ymgme.2010.09.003.
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    • Il’yasova, Dora, Kelly Kennedy, Ivan Spasojevic, Frances Wang, Adviye A. Tolun, Karel Base, Sarah P. Young, et al. “Individual responses to chemotherapy-induced oxidative stress.” Breast Cancer Res Treat 125, no. 2 (January 2011): 583–89. https://doi.org/10.1007/s10549-010-1158-7.
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    • Millington, David S., and Robert D. Stevens. “Acylcarnitines: analysis in plasma and whole blood using tandem mass spectrometry.” Methods Mol Biol 708 (2011): 55–72. https://doi.org/10.1007/978-1-61737-985-7_3.
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    • Auray-Blais, Christiane, Aimé Ntwari, Joe T. R. Clarke, David G. Warnock, João Paulo Oliveira, Sarah P. Young, David S. Millington, et al. “How well does urinary lyso-Gb3 function as a biomarker in Fabry disease?” Clin Chim Acta 411, no. 23–24 (December 14, 2010): 1906–14. https://doi.org/10.1016/j.cca.2010.07.038.
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    • Dessein, Anne-Frédérique, Monique Fontaine, Brage S. Andresen, Niels Gregersen, Michèle Brivet, Daniel Rabier, Silvia Napuri-Gouel, et al. “A novel mutation of the ACADM gene (c.145C>G) associated with the common c.985A>G mutation on the other ACADM allele causes mild MCAD deficiency: a case report.” Orphanet J Rare Dis 5 (October 5, 2010): 26. https://doi.org/10.1186/1750-1172-5-26.
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    • Tolun, Adviye A., Haoyue Zhang, Dora Il’yasova, Judit Sztáray, Sarah P. Young, and David S. Millington. “Allantoin in human urine quantified by ultra-performance liquid chromatography-tandem mass spectrometry.” Anal Biochem 402, no. 2 (July 15, 2010): 191–93. https://doi.org/10.1016/j.ab.2010.03.033.
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    • Il’yasova, Dora, Ivan Spasojevic, Frances Wang, Adviye A. Tolun, Karel Base, Sarah P. Young, P Kelly Marcom, et al. “Urinary biomarkers of oxidative status in a clinical model of oxidative assault.” Cancer Epidemiol Biomarkers Prev 19, no. 6 (June 2010): 1506–10. https://doi.org/10.1158/1055-9965.EPI-10-0211.
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    • Zhang, Haoyue, Dora Il’yasova, Judit Sztaray, Sarah P. Young, Frances Wang, and David S. Millington. “Quantification of the oxidative damage biomarker 2,3-dinor-8-isoprostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry.” Anal Biochem 399, no. 2 (April 15, 2010): 302–4. https://doi.org/10.1016/j.ab.2009.12.024.
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    • Millington, David S., Ramakrishna Sista, Allen Eckhardt, Jeremy Rouse, Deeksha Bali, Ronald Goldberg, Michael Cotten, Rebecca Buckley, and Vamsee Pamula. “Digital microfluidics: a future technology in the newborn screening laboratory?” Semin Perinatol 34, no. 2 (April 2010): 163–69. https://doi.org/10.1053/j.semperi.2009.12.008.
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    • Auray-Blais, Christiane, David S. Millington, Caroline Barr, Sarah P. Young, Kevin Mills, and Joe T. R. Clarke. “Gb(3)/creatinine biomarkers for Fabry disease: issues to consider.” Mol Genet Metab 97, no. 3 (July 2009): 237. https://doi.org/10.1016/j.ymgme.2009.04.006.
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    • Goldstein, Jennifer L., Sarah P. Young, Mohita Changela, Gwen H. Dickerson, Haoyue Zhang, Jian Dai, Denise Peterson, David S. Millington, Priya S. Kishnani, and Deeksha S. Bali. “Screening for Pompe disease using a rapid dried blood spot method: experience of a clinical diagnostic laboratory.” Muscle Nerve 40, no. 1 (July 2009): 32–36. https://doi.org/10.1002/mus.21376.
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    • Surwit, Richard S., James D. Lane, David S. Millington, Haoyue Zhang, Mark N. Feinglos, Sharon Minda, Rhonda Merwin, Cynthia M. Kuhn, Raymond C. Boston, and Anastasia Georgiades. “Hostility and minimal model of glucose kinetics in African American women.” Psychosom Med 71, no. 6 (July 2009): 646–51. https://doi.org/10.1097/PSY.0b013e3181acee4c.
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    • Young, Sarah P., Haoyue Zhang, Deyanira Corzo, Beth L. Thurberg, Deeksha Bali, Priya S. Kishnani, and David S. Millington. “Long-term monitoring of patients with infantile-onset Pompe disease on enzyme replacement therapy using a urinary glucose tetrasaccharide biomarker.” Genet Med 11, no. 7 (July 2009): 536–41. https://doi.org/10.1097/GIM.0b013e3181a87867.
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    • Newgard, C. B., J. An, J. R. Bain, M. J. Muehlbauer, R. D. Stevens, L. F. Lien, A. M. Haqq, et al. “A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance (DOI:10.1016/j.cmet.2009.02.002).” Cell Metabolism 9, no. 6 (May 14, 2009): 565–66. https://doi.org/10.1016/j.cmet.2009.05.001.
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    • Auray-Blais, C., D. S. Millington, S. P. Young, J. T. R. Clarke, and R. Schiffmann. “Proposed high-risk screening protocol for Fabry disease in patients with renal and vascular disease.” J Inherit Metab Dis 32, no. 2 (April 2009): 303–8. https://doi.org/10.1007/s10545-009-1055-6.
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    • Newgard, Christopher B., Jie An, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, Lillian F. Lien, Andrea M. Haqq, et al. “A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.” Cell Metab 9, no. 4 (April 2009): 311–26. https://doi.org/10.1016/j.cmet.2009.02.002.
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    • Zhang, Haoyue, Robert D. Stevens, Sarah P. Young, Richard Surwit, Anastasia Georgiades, Raymond Boston, and David S. Millington. “A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6]glucose as a tracer.” Clin Chem 55, no. 3 (March 2009): 527–32. https://doi.org/10.1373/clinchem.2008.113654.
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    • Lien, Lillian F., Andrea M. Haqq, Michelle Arlotto, Cris A. Slentz, Michael J. Muehlbauer, Ross L. McMahon, James Rochon, et al. “The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.” Omics 13, no. 1 (February 2009): 21–35. https://doi.org/10.1089/omi.2008.0035.
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    • Auray-Blais, C., D. Cyr, R. Drouin, J. T. R. Clarke, and D. S. Millington. “Use of urinary globotriaosylceramide for fabry disease screening in Canada.” Clinical Therapeutics 30, no. SUPPL. 3 (November 19, 2008). https://doi.org/10.1016/S0149-2918(08)00360-3.
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    • Millington, David S. “Rapid and effective screening for lysosomal storage disease: how close are we?” Clin Chem 54, no. 10 (October 2008): 1592–94. https://doi.org/10.1373/clinchem.2008.112110.
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    • Wolfgang, Michael J., Seung Hun Cha, David S. Millington, Gary Cline, Gerald I. Shulman, Akira Suwa, Makoto Asaumi, Takeshi Kurama, Teruhiko Shimokawa, and M Daniel Lane. “Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight.” J Neurochem 105, no. 4 (May 2008): 1550–59. https://doi.org/10.1111/j.1471-4159.2008.05255.x.
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    • Sherwin, J. E., G. Lockitch, P. Rosenthal, S. Rhone, L. A. Magee, E. R. Ashwood, B. M. Goldsmith, et al. “Guidelines for clinical laboratory practice: Evaluation of maternal-fetal risk and reference values in pregnancy. Section V and VII.” Acta Bioquimica Clinica Latinoamericana 41, no. 4 (October 1, 2007): 563–86.
    • Koeberl, D. D., B. D. Sun, T. V. Damodaran, T. Brown, D. S. Millington, J. K. Benjamin, A. Bird, et al. “Erratum: Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia (Gene Therapy (2006) vol. 13 (1281-1289) 10.1038/sj.gt.3302774).” Gene Therapy 14, no. 3 (February 1, 2007): 281. https://doi.org/10.1038/sj.gt.3302903.
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    • Kao, Hsiao-Jung, Ching-Feng Cheng, Yen-Hui Chen, Shuen-Iu Hung, Cheng-Chih Huang, David Millington, Tateki Kikuchi, Jer-Yuarn Wu, and Yuan-Tsong Chen. “ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit.” Hum Mol Genet 15, no. 24 (December 15, 2006): 3569–77. https://doi.org/10.1093/hmg/ddl433.
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    • Koeberl, D. D., B. D. Sun, T. V. Damodaran, T. Brown, D. S. Millington, D. K. Benjamin, A. Bird, et al. “Erratum: Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia (Gene Therapy (2006) vol. 13 (1281-1289) 10.1038/sj.gt.3302774)).” Gene Therapy 13, no. 19 (October 1, 2006): 1430. https://doi.org/10.1038/sj.gt.3302857.
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    • Pedersen, Christina B., Claus Bischoff, Ernst Christensen, Henrik Simonsen, Allan M. Lund, Sarah P. Young, Dwight D. Koeberl, et al. “Variations in IBD (ACAD8) in children with elevated C4-carnitine detected by tandem mass spectrometry newborn screening.” Pediatr Res 60, no. 3 (September 2006): 315–20. https://doi.org/10.1203/01.pdr.0000233085.72522.04.
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    • Koeberl, D. D., B. D. Sun, T. V. Damodaran, T. Brown, D. S. Millington, D. K. Benjamin, A. Bird, et al. “Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia.” Gene Ther 13, no. 17 (September 2006): 1281–89. https://doi.org/10.1038/sj.gt.3302774.
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    • Sweetman, L., D. S. Millington, and B. L. Therrell. “Erratum: Naming and counting disorders (conditions) included in newborn screening panels (Pediatrics (May 2006) 117 (S308-S314) doi 10.1542/peds.2005- 2633J).” Pediatrics 118, no. 2 (August 1, 2006): 851. https://doi.org/10.1542/peds.2006-1566.
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    • Kishnani, P. S., R. D. Steiner, D. Bali, K. Berger, B. J. Byrne, L. E. Case, J. F. Crowley, et al. “Erratum: Pompe disease diagnosis and management guidelines (Genetics in Medicine (May 2006) 8 (267-288)).” Genetics in Medicine 8, no. 6 (June 1, 2006): 382. https://doi.org/10.1097/00125817-200606000-00008.
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    • Sweetman, Lawrence, David S. Millington, Bradford L. Therrell, W Harry Hannon, Bradley Popovich, Michael S. Watson, Marie Y. Mann, Michele A. Lloyd-Puryear, and Peter C. van Dyck. “Naming and counting disorders (conditions) included in newborn screening panels.” Pediatrics 117, no. 5 Pt 2 (May 2006): S308–14. https://doi.org/10.1542/peds.2005-2633J.
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    • Kishnani, Priya S., Robert D. Steiner, Deeksha Bali, Kenneth Berger, Barry J. Byrne, Laura E. Case, John F. Crowley, et al. “Pompe disease diagnosis and management guideline.” Genet Med 8, no. 5 (May 2006): 267–88. https://doi.org/10.1097/01.gim.0000218152.87434.f3.
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    • Zhang, Haoyue, Helmut Kallwass, Sarah P. Young, Cortney Carr, Jian Dai, Priya S. Kishnani, David S. Millington, Joan Keutzer, Yuan-Tsong Chen, and Deeksha Bali. “Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease.” Genet Med 8, no. 5 (May 2006): 302–6. https://doi.org/10.1097/01.gim.0000217781.66786.9b.
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    • Frazier, D. M., D. S. Millington, S. E. McCandless, D. D. Koeberl, S. D. Weavil, S. H. Chaing, and J. Muenzer. “The tandem mass spectrometry newborn screening experience in North Carolina: 1997-2005.” J Inherit Metab Dis 29, no. 1 (February 2006): 76–85. https://doi.org/10.1007/s10545-006-0228-9.
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    • Haqq, Andrea M., Lillian F. Lien, Jarol Boan, Michelle Arlotto, Cris A. Slentz, Michael J. Muehlbauer, James Rochon, et al. “The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.” Contemp Clin Trials 26, no. 6 (December 2005): 616–25. https://doi.org/10.1016/j.cct.2005.09.003.
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    • An, Yan, Sarah P. Young, Priya S. Kishnani, David S. Millington, Andrea Amalfitano, Deyanira Corz, and Yuan-Tsong Chen. “Glucose tetrasaccharide as a biomarker for monitoring the therapeutic response to enzyme replacement therapy for Pompe disease.” Mol Genet Metab 85, no. 4 (August 2005): 247–54. https://doi.org/10.1016/j.ymgme.2005.03.010.
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    • Millington, David S. “Newborn screening for lysosomal storage disorders.” Clin Chem 51, no. 5 (May 2005): 808–9. https://doi.org/10.1373/clinchem.2005.048553.
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    • An, Jie, Deborah M. Muoio, Masakazu Shiota, Yuka Fujimoto, Gary W. Cline, Gerald I. Shulman, Timothy R. Koves, Robert Stevens, David Millington, and Christopher B. Newgard. “Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.” Nat Med 10, no. 3 (March 2004): 268–74. https://doi.org/10.1038/nm995.
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    • Wu, Jer-Yuarn, Hsiao-Jung Kao, Sing-Chung Li, Robert Stevens, Steven Hillman, David Millington, and Yuan-Tsong Chen. “ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.” J Clin Invest 113, no. 3 (February 2004): 434–40. https://doi.org/10.1172/JCI19574.
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    • Young, Sarah P., Dietrich Matern, Niels Gregersen, Robert D. Stevens, Deeksha Bali, Hui-Ming Liu, Dwight D. Koeberl, and David S. Millington. “A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency.” Clin Chim Acta 337, no. 1–2 (November 2003): 103–13. https://doi.org/10.1016/j.cccn.2003.07.006.
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    • Koeberl, Dwight D., Sarah P. Young, Niels S. Gregersen, Jerry Vockley, Wendy E. Smith, Daniel Kelly Benjamin, Yan An, et al. “Rare disorders of metabolism with elevated butyryl- and isobutyryl-carnitine detected by tandem mass spectrometry newborn screening.” Pediatr Res 54, no. 2 (August 2003): 219–23. https://doi.org/10.1203/01.PDR.0000074972.36356.89.
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    • Young, Sarah P., Robert D. Stevens, Yan An, Yuan-Tsong Chen, and David S. Millington. “Analysis of a glucose tetrasaccharide elevated in Pompe disease by stable isotope dilution-electrospray ionization tandem mass spectrometry.” Anal Biochem 316, no. 2 (May 15, 2003): 175–80. https://doi.org/10.1016/s0003-2697(03)00056-3.
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    • Koeberl, D. D., D. S. Millington, W. E. Smith, S. D. Weavil, J. Muenzer, S. E. McCandless, P. S. Kishnani, et al. “Evaluation of 3-methylcrotonyl-CoA carboxylase deficiency detected by tandem mass spectrometry newborn screening.” J Inherit Metab Dis 26, no. 1 (2003): 25–35. https://doi.org/10.1023/a:1024015227863.
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    • An, Y., R. D. Stevens, J. Muenzer, J. T. R. Clarke, and D. S. Millington. “An LC-MS/MS method for determination of glycosaminoglycan content of urine for the diagnosis of mucopolysaccharidoses.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, December 1, 2002, 597–98.
    • Young, S. P., Y. An, J. Van Hove, R. D. Stevens, Y. T. Chen, and D. S. Millington. “Isomeric oligosaccharide analysis using hydrophilic interaction LC-ESI-MS/MS.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, December 1, 2002, 413–14.
    • Kohn, Michael C., Abdul S. Tohmaz, Karen J. Giroux, Gregory M. Blumenthal, Michael D. Feezor, and David S. Millington. “Robustness of MetaNet graph models: predicting control of urea production in humans.” Biosystems 65, no. 1 (February 2002): 61–78. https://doi.org/10.1016/s0303-2647(02)00002-3.
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    • Millington, D. S. “Newborn screening for metabolic diseases.” American Scientist 90, no. 1 (January 1, 2002): 40–47. https://doi.org/10.1511/2002.13.752.
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    • Simpson, D. M., D. Katzenstein, B. Haidich, D. Millington, C. Yiannoutsos, G. Schifitto, J. McArthur, and J. AIDS Clinical Trials Group Protocol 291/860 Study Team. “Plasma carnitine in HIV-associated neuropathy.” Aids 15, no. 16 (November 9, 2001): 2207–8. https://doi.org/10.1097/00002030-200111090-00025.
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    • Cox, K. B., D. A. Hamm, D. S. Millington, D. Matern, J. Vockley, P. Rinaldo, C. A. Pinkert, W. J. Rhead, J. R. Lindsey, and P. A. Wood. “Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse.” Hum Mol Genet 10, no. 19 (September 15, 2001): 2069–77. https://doi.org/10.1093/hmg/10.19.2069.
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    • Smith, W. E., D. S. Millington, D. D. Koeberl, and P. S. Lesser. “Glutaric acidemia, type I, missed by newborn screening in an infant with dystonia following promethazine administration.” Pediatrics 107, no. 5 (May 2001): 1184–87. https://doi.org/10.1542/peds.107.5.1184.
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    • Matern, D., P. Hart, A. P. Murtha, J. Vockley, N. Gregersen, D. S. Millington, and W. R. Treem. “Acute fatty liver of pregnancy associated with short-chain acyl-coenzyme A dehydrogenase deficiency.” J Pediatr 138, no. 4 (April 2001): 585–88. https://doi.org/10.1067/mpd.2001.111814.
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    • An, Y., S. P. Young, S. L. Hillman, J. L. Van Hove, Y. T. Chen, and D. S. Millington. “Liquid chromatographic assay for a glucose tetrasaccharide, a putative biomarker for the diagnosis of Pompe disease.” Anal Biochem 287, no. 1 (December 1, 2000): 136–43. https://doi.org/10.1006/abio.2000.4838.
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    • Koeberl, D. D., S. Young, M. McDonald, G. Vockley, N. Gregersen, A. Boney, and D. S. Millington. “Detection by newborn screening of asymptomatic, putative short-chain acylCoA dehydrogenase (SCAD) deficiency.” American Journal of Human Genetics 67, no. 4 (October 1, 2000): 278–278.
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    • Smith, W. E., J. Muenzer, D. Frazier, D. S. Millington, P. S. Kishnani, M. McDonald, and D. D. Koeberl. “Evaluation of elevated hydroxyisovalerylcarnitine in the newborn screen by tandem mass spectrometry.” American Journal of Human Genetics 67, no. 4 (October 1, 2000): 292–292.
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    • Van Hove, J. L., S. G. Kahler, M. D. Feezor, J. P. Ramakrishna, P. Hart, W. R. Treem, J. J. Shen, D. Matern, and D. S. Millington. “Acylcarnitines in plasma and blood spots of patients with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase defiency.” J Inherit Metab Dis 23, no. 6 (September 2000): 571–82. https://doi.org/10.1023/a:1005673828469.
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    • Gibson, K. M., T. G. Burlingame, B. Hogema, C. Jakobs, R. B. Schutgens, D. Millington, C. R. Roe, et al. “2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism.” Pediatr Res 47, no. 6 (June 2000): 830–33. https://doi.org/10.1203/00006450-200006000-00025.
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    • Stevens, R. D., S. L. Hillman, S. Worthy, D. Sanders, and D. S. Millington. “Assay for free and total carnitine in human plasma using tandem mass spectrometry.” Clin Chem 46, no. 5 (May 2000): 727–29.
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    • Shen, J. J., D. Matern, D. S. Millington, S. Hillman, M. D. Feezor, M. J. Bennett, M. Qumsiyeh, S. G. Kahler, Y. T. Chen, and J. L. Van Hove. “Acylcarnitines in fibroblasts of patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and other fatty acid oxidation disorders.” J Inherit Metab Dis 23, no. 1 (February 2000): 27–44. https://doi.org/10.1023/a:1005694712583.
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    • Center, S. A., J. Harte, D. Watrous, A. Reynolds, T. D. Watson, P. J. Markwell, D. S. Millington, P. A. Wood, A. E. Yeager, and H. N. Erb. “The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine.” J Vet Intern Med 14, no. 6 (2000): 598–608. https://doi.org/10.1892/0891-6640(2000)014<0598:tcameo>2.3.co;2.
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    • Ahmad, A., S. G. Kahler, P. S. Kishnani, M. Artigas-Lopez, A. S. Pappu, R. Steiner, D. S. Millington, and J. L. Van Hove. “Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate.” Am J Med Genet 87, no. 4 (December 3, 1999): 331–38. https://doi.org/10.1002/(sici)1096-8628(19991203)87:4<331::aid-ajmg10>3.0.co;2-k.
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    • Matern, D., P. Hart, A. P. Murtha, G. Vockley, N. Gregersen, D. S. Millington, and W. R. Treem. “Broadening the spectrum of fetal fatty acid beta-oxidation (FAO) disorders causing liver disease in pregnant women.” American Journal of Human Genetics 65, no. 4 (October 1, 1999): A45–A45.
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    • Matern, D., A. W. Strauss, S. L. Hillman, E. Mayatepek, D. S. Millington, and F. K. Trefz. “Diagnosis of mitochondrial trifunctional protein deficiency in a blood spot from the newborn screening card by tandem mass spectrometry and DNA analysis.” Pediatr Res 46, no. 1 (July 1999): 45–49. https://doi.org/10.1203/00006450-199907000-00008.
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    • Rose, M., D. Matern, D. S. Millington, and W. Lehnert. “Untypical case of multiple acyl-CoA-dehydrogenase deficiency.” Klinische Padiatrie 211, no. 5 (1999): 413–16.
    • Lee, C., F. J. Tsai, J. Y. Wu, C. T. Peng, C. H. Tsai, W. L. Hwu, T. R. Wang, and D. S. Millington. “3-hydroxy-3-methylglutaric aciduria presenting with Reye like syndrome: report of one case.” Acta Paediatr Taiwan 40, no. 6 (1999): 445–47.
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    • Rose, M., D. Matern, D. S. Millington, and W. Lehnert. “[Atypical course of a multiple acyl-CoA-dehydrogenase deficiency].” Klin Padiatr 211, no. 5 (1999): 413–16. https://doi.org/10.1055/s-2008-1043823.
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    • Kurtz, D. M., P. Rinaldo, W. J. Rhead, L. Tian, D. S. Millington, J. Vockley, D. A. Hamm, et al. “Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation.” Proc Natl Acad Sci U S A 95, no. 26 (December 22, 1998): 15592–97. https://doi.org/10.1073/pnas.95.26.15592.
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    • Russell, B. G., W. E. Moddeman, J. C. Birkbeck, S. E. Wright, D. S. Millington, R. D. Stevens, and K. E. Dombrowski. “Surface structure of human mucin using X-ray photoelectron spectroscopy.” Biospectroscopy 4, no. 4 (1998): 257–66. https://doi.org/10.1002/(sici)1520-6343(1998)4:4<257::aid-bspy4>3.0.co;2-#.
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    • Triggs, W. J., R. L. Gilmore, D. S. Millington, J. Cibula, T. S. Bunch, and E. Harman. “Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure.” Int J Clin Pharmacol Ther 35, no. 9 (September 1997): 353–56.
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    • Kantrow, S. P., Y. C. T. Huang, A. R. Whorton, E. N. Grayck, J. M. Knight, D. S. Millington, and C. A. Piantadosi. “Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung.” American Journal of Physiology Lung Cellular and Molecular Physiology 272, no. 6 (June 1, 1997): L1167–73.
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    • Kantrow, S. P., Y. C. Huang, A. R. Whorton, E. N. Grayck, J. M. Knight, D. S. Millington, and C. A. Piantadosi. “Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung.” Am J Physiol 272, no. 6 Pt 1 (June 1997): L1167–73. https://doi.org/10.1152/ajplung.1997.272.6.L1167.
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    • Treem, W. R., M. E. Shoup, D. E. Hale, M. J. Bennett, P. Rinaldo, D. S. Millington, C. A. Stanley, C. A. Riely, and J. S. Hyams. “Acute fatty liver of pregnancy, hemolysis, elevated liver enzymes, and low platelets syndrome, and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency.” Am J Gastroenterol 91, no. 11 (November 1996): 2293–2300.
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    • Stevens, M. J., S. A. Lattimer, E. L. Feldman, E. D. Helton, D. S. Millington, A. A. Sima, and D. A. Greene. “Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat.” Metabolism 45, no. 7 (July 1996): 865–72. https://doi.org/10.1016/s0026-0495(96)90161-4.
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    • Chace, D. H., S. L. Hillman, D. S. Millington, S. G. Kahler, B. W. Adam, and H. L. Levy. “Rapid diagnosis of homocystinuria and other hypermethioninemias from newborns' blood spots by tandem mass spectrometry.” Clin Chem 42, no. 3 (March 1996): 349–55.
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    • Feoli-Fonseca, J. C., M. Lambert, G. Mitchell, S. B. Melançon, L. Dallaire, D. S. Millington, and I. A. Qureshi. “Chronic sodium benzoate therapy in children with inborn errors of urea synthesis: effect on carnitine metabolism and ammonia nitrogen removal.” Biochem Mol Med 57, no. 1 (February 1996): 31–36. https://doi.org/10.1006/bmme.1996.0006.
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    • Brivet, M., A. Slama, D. S. Millington, C. R. Roe, F. Demaugre, A. Legrand, A. Boutron, F. Poggi, and J. M. Saudubray. “Retrospective diagnosis of carnitine-acylcarnitine translocase deficiency by acylcarnitine analysis in the proband Guthrie card and enzymatic studies in the parents.” J Inherit Metab Dis 19, no. 2 (1996): 181–84. https://doi.org/10.1007/BF01799424.
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    • Van Hove, J. L., P. Kishnani, J. Muenzer, R. J. Wenstrup, M. L. Summar, M. R. Brummond, A. M. Lachiewicz, D. S. Millington, and S. G. Kahler. “Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia.” Am J Med Genet 59, no. 4 (December 4, 1995): 444–53. https://doi.org/10.1002/ajmg.1320590410.
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    • Röschinger, W., D. S. Millington, D. A. Gage, Z. H. Huang, T. Iwamoto, S. Yano, S. Packman, K. Johnston, S. A. Berry, and L. Sweetman. “3-Hydroxyisovalerylcarnitine in patients with deficiency of 3-methylcrotonyl CoA carboxylase.” Clin Chim Acta 240, no. 1 (August 31, 1995): 35–51. https://doi.org/10.1016/0009-8981(95)06126-2.
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    • Chace, D. H., S. L. Hillman, D. S. Millington, S. G. Kahler, C. R. Roe, and E. W. Naylor. “Rapid diagnosis of maple syrup urine disease in blood spots from newborns by tandem mass spectrometry.” Clin Chem 41, no. 1 (January 1995): 62–68.
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    • Hove, J. L. van, S. L. Rutledge, M. A. Nada, S. G. Kahler, and D. S. Millington. “3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency.” J Inherit Metab Dis 18, no. 5 (1995): 592–601. https://doi.org/10.1007/BF02436004.
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    • Rutledge, S. L., G. T. Berry, C. A. Stanley, J. L. van Hove, and D. Millington. “Glycine and L-carnitine therapy in 3-methylcrotonyl-CoA carboxylase deficiency.” J Inherit Metab Dis 18, no. 3 (1995): 299–305. https://doi.org/10.1007/BF00710419.
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    • Tein, I., A. E. Sloane, E. J. Donner, D. C. Lehotay, D. S. Millington, and R. I. Kelley. “Fatty acid oxidation abnormalities in childhood-onset spinal muscular atrophy: primary or secondary defect(s)?” Pediatr Neurol 12, no. 1 (January 1995): 21–30. https://doi.org/10.1016/0887-8994(94)00100-g.
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    • Matchar, D. B., D. C. McCrory, D. S. Millington, and J. R. Feussner. “Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency.” Am J Med Sci 308, no. 5 (November 1994): 276–83. https://doi.org/10.1097/00000441-199411000-00004.
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    • Ozand, P. T., M. Rashed, D. S. Millington, N. Sakati, S. Hazzaa, Z. Rahbeeni, A. al Odaib, N. Youssef, A. Mazrou, and G. G. Gascon. “Ethylmalonic aciduria: an organic acidemia with CNS involvement and vasculopathy.” Brain Dev 16 Suppl (November 1994): 12–22. https://doi.org/10.1016/0387-7604(94)90092-2.
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    • Bonaventura, C., J. Bonaventura, R. Stevens, and D. Millington. “Acrylamide in polyacrylamide gels can modify proteins during electrophoresis.” Anal Biochem 222, no. 1 (October 1994): 44–48. https://doi.org/10.1006/abio.1994.1451.
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    • Stevens, R. D., J. Bonaventura, C. Bonaventura, T. R. Fennel, and D. S. Millington. “Application of electrospray ionization mass spectrometry for analysis of haemoglobin adducts with acrylonitrile.” Biochem Soc Trans 22, no. 2 (May 1994): 543–47. https://doi.org/10.1042/bst0220543.
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    • Treem, W. R., P. Rinaldo, D. E. Hale, C. A. Stanley, D. S. Millington, J. S. Hyams, S. Jackson, and D. M. Turnbull. “Acute fatty liver of pregnancy and long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency.” Hepatology 19, no. 2 (February 1994): 339–45.
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    • Van Hove, J. L., S. G. Kahler, D. S. Millington, D. S. Roe, D. H. Chace, S. J. Heales, and C. R. Roe. “Intravenous L-carnitine and acetyl-L-carnitine in medium-chain acyl-coenzyme A dehydrogenase deficiency and isovaleric acidemia.” Pediatr Res 35, no. 1 (January 1994): 96–101. https://doi.org/10.1203/00006450-199401000-00020.
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    • Van Hove, J. L., W. Zhang, S. G. Kahler, C. R. Roe, Y. T. Chen, N. Terada, D. H. Chace, A. K. Iafolla, J. H. Ding, and D. S. Millington. “Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood.” Am J Hum Genet 52, no. 5 (May 1993): 958–66.
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    • Millington, D. S., and G. Dubay. “Dietary supplement L-carnitine: Analysis of different brands to determine bioavailability and content.” Clinical Research and Regulatory Affairs 10, no. 2 (January 1, 1993): 71–80.
    • Chace, D. H., D. S. Millington, N. Terada, S. G. Kahler, C. R. Roe, and L. F. Hofman. “Rapid diagnosis of phenylketonuria by quantitative analysis for phenylalanine and tyrosine in neonatal blood spots by tandem mass spectrometry.” Clin Chem 39, no. 1 (January 1993): 66–71.
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    • Van Hove, J. L., D. H. Chace, S. G. Kahler, and D. S. Millington. “Acylcarnitines in amniotic fluid: application to the prenatal diagnosis of propionic acidaemia.” J Inherit Metab Dis 16, no. 2 (1993): 361–67. https://doi.org/10.1007/BF00710283.
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    • Roe, D. S., N. Terada, and D. S. Millington. “Automated analysis for free and short-chain acylcarnitine in plasma with a centrifugal analyzer.” Clin Chem 38, no. 11 (November 1992): 2215–20.
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    • Campistol, J., A. Ribes, L. Alvarez, E. Christensen, and D. S. Millington. “Glutaric aciduria type I: unusual biochemical presentation.” J Pediatr 121, no. 1 (July 1992): 83–86. https://doi.org/10.1016/s0022-3476(05)82548-x.
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    • Portilla, D., L. J. Mandel, D. Bar-Sagi, and D. S. Millington. “Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules.” Am J Physiol 262, no. 3 Pt 2 (March 1992): F354–60. https://doi.org/10.1152/ajprenal.1992.262.3.F354.
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    • Mao, L. F., D. S. Millington, and H. Schulz. “Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid.” J Biol Chem 267, no. 5 (February 15, 1992): 3143–46.
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    • Berman, J., M. Green, E. Sugg, R. Anderegg, D. S. Millington, D. L. Norwood, J. McGeehan, and J. Wiseman. “Rapid optimization of enzyme substrates using defined substrate mixtures.” J Biol Chem 267, no. 3 (January 25, 1992): 1434–37.
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    • Bennett, M. J., P. Rinaldo, I. Yokota, D. S. Millington, and P. M. Coates. “Letter to the editor.” Fetal and Pediatric Pathology 12, no. 4 (January 1, 1992): 621–25. https://doi.org/10.3109/15513819209024213.
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    • Ding, J. H., P. Bross, B. Z. Yang, A. K. Iafolla, D. S. Millington, C. R. Roe, N. Gregersen, and Y. T. Chen. “Genetic heterogeneity in MCAD deficiency: frequency of K329E allele and identification of three additional mutant alleles.” Prog Clin Biol Res 375 (1992): 479–88.
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    • Doerge, D. R., S. Bajic, and D. S. Millington. “Analysis of pesticides using liquid chromatography/atmospheric‐pressure chemical ionization mass spectrometry.” Rapid Communications in Mass Spectrometry 6, no. 11 (January 1, 1992): 663–66. https://doi.org/10.1002/rcm.1290061107.
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    • Millington, D. S., N. Terada, D. H. Chace, Y. T. Chen, J. H. Ding, N. Kodo, and C. R. Roe. “The role of tandem mass spectrometry in the diagnosis of fatty acid oxidation disorders.” Prog Clin Biol Res 375 (1992): 339–54.
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    • Ribes, A., E. Riudor, P. Briones, E. Christensen, J. Campistol, and D. S. Millington. “Significance of bound glutarate in the diagnosis of glutaric aciduria type I.” J Inherit Metab Dis 15, no. 3 (1992): 367–70. https://doi.org/10.1007/BF02435978.
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    • Millington, D. S., N. Kodo, N. Terada, D. Roe, and D. H. Chace. “The analysis of diagnostic markers of genetic disorders in human blood and urine using tandem mass spectrometry with liquid secondary ion mass spectrometry.” International Journal of Mass Spectrometry and Ion Processes 111, no. C (December 16, 1991): 211–28. https://doi.org/10.1016/0168-1176(91)85056-R.
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    • Millington, D. S., D. L. Norwood, N. Kodo, R. Moore, M. D. Green, and J. Berman. “Biomedical applications of high-performance liquid chromatography-mass spectrometry with continuous-flow fast atom bombardment.” J Chromatogr 562, no. 1–2 (January 2, 1991): 47–58. https://doi.org/10.1016/0378-4347(91)80563-r.
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    • Bennett, M. J., P. Rinaldo, D. S. Millington, K. Tanaka, I. Yokota, and P. M. Coates. “Medium-chain acyl-CoA dehydrogenase deficiency: postmortem diagnosis in a case of sudden infant death and neonatal diagnosis of an affected sibling.” Pediatr Pathol 11, no. 6 (1991): 889–95. https://doi.org/10.3109/15513819109065485.
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    • Burlingame, A. L., D. S. Millington, D. L. Norwood, and D. H. Russell. “Mass spectrometry.” Anal Chem 62, no. 12 (June 15, 1990): 268R-303R.
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    • Norwood, D. L., C. A. Bus, and D. S. Millington. “Combined high-performance liquid chromatographic-continuous-flow fast atom bombardment mass spectrometric analysis of acylcoenzyme A compounds.” J Chromatogr 527, no. 2 (May 18, 1990): 289–301. https://doi.org/10.1016/s0378-4347(00)82113-1.
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    • Roe, C. R., D. S. Millington, D. L. Norwood, N. Kodo, H. Sprecher, B. S. Mohammed, M. Nada, H. Schulz, and R. McVie. “2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation.” J Clin Invest 85, no. 5 (May 1990): 1703–7. https://doi.org/10.1172/JCI114624.
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    • Kodo, N., D. S. Millington, D. L. Norwood, and C. R. Roe. “Quantitative assay of free and total carnitine using tandem mass spectrometry.” Clin Chim Acta 186, no. 3 (January 31, 1990): 383–90. https://doi.org/10.1016/0009-8981(90)90324-l.
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    • Burlingame, A. L., D. S. Millington, D. L. Norwood, and D. H. Russell. “Mass Spectrometry.” Analytical Chemistry 62, no. 12 (January 1, 1990): 155–69. https://doi.org/10.1021/ac00211a014.
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    • Roe, C. R., D. S. Millington, S. G. Kahler, N. Kodo, and D. L. Norwood. “Carnitine homeostasis in the organic acidurias.” Prog Clin Biol Res 321 (1990): 383–402.
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    • Wood, P. A., B. A. Amendt, W. J. Rhead, D. Armstrong, D. S. Millington, and F. Inoue. “A murine model for short-chain acyl-CoA dehydrogenase deficiency.” Prog Clin Biol Res 321 (1990): 427–34.
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    • Bennett, M. J., P. M. Coates, D. E. Hale, D. S. Millington, R. J. Pollitt, P. Rinaldo, C. R. Roe, and K. Tanaka. “Analysis of abnormal urinary metabolites in the newborn period in medium-chain acyl-CoA dehydrogenase deficiency.” J Inherit Metab Dis 13, no. 5 (1990): 707–15. https://doi.org/10.1007/BF01799572.
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    • Millington, D. S., N. Kodo, D. L. Norwood, and C. R. Roe. “Tandem mass spectrometry: a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism.” J Inherit Metab Dis 13, no. 3 (1990): 321–24. https://doi.org/10.1007/BF01799385.
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    • Moore, R., D. S. Millington, D. Norwood, N. Kodo, P. Robinson, and J. F. Glasgow. “Identification of phenylpropionylcarnitine, a new metabolite of phenylpropionic acid, in a patient with medium chain acyl-CoA dehydrogenase deficiency.” J Inherit Metab Dis 13, no. 3 (1990): 325–29. https://doi.org/10.1007/BF01799386.
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    • Kahler, S. G., D. S. Millington, S. D. Cederbaum, J. Vargas, L. D. Bond, D. A. Maltby, D. S. Gale, and C. R. Roe. “Parenteral nutrition in propionic and methylmalonic acidemia.” J Pediatr 115, no. 2 (August 1989): 235–41. https://doi.org/10.1016/s0022-3476(89)80071-x.
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    • Sansbury, K., D. S. Millington, and R. A. Coleman. “Hepatic monoacylglycerol acyltransferase: ontogeny and characterization of an activity associated with the chick embryo.” J Lipid Res 30, no. 8 (August 1989): 1251–58.
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    • Chen, L. S., D. S. Millington, D. A. Maltby, and J. O. McNamara. “Effects of intranigral application of clinically-effective anticonvulsants on electroshock-induced seizures.” Neuropharmacology 28, no. 8 (August 1989): 781–86. https://doi.org/10.1016/0028-3908(89)90167-6.
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    • Millington, D. S., D. L. Norwood, N. Kodo, C. R. Roe, and F. Inoue. “Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography/mass spectrometry to the analysis of acylcarnitines in human urine, blood, and tissue.” Anal Biochem 180, no. 2 (August 1, 1989): 331–39. https://doi.org/10.1016/0003-2697(89)90441-7.
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    • Millington, D. S., and C. R. Roe. “Medium-chain acyl-CoA dehydrogenase deficiency.” N Engl J Med 320, no. 18 (May 4, 1989): 1219. https://doi.org/10.1056/NEJM198905043201817.
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    • Wood, P. A., B. A. Amendt, W. J. Rhead, D. S. Millington, F. Inoue, and D. Armstrong. “Short-chain acyl-coenzyme A dehydrogenase deficiency in mice.” Pediatr Res 25, no. 1 (January 1989): 38–43. https://doi.org/10.1203/00006450-198901000-00010.
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    • Norwood, D. L., N. Kodo, and D. S. Millington. “Application of continuous-flow liquid chromatography/fast-atom bombardment mass spectrometry to the analysis of diagnostic acylcarnitines in human urine.” Rapid Commun Mass Spectrom 2, no. 12 (December 1988): 269–72. https://doi.org/10.1002/rcm.1290021205.
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    • Pramanik, B. C., S. M. Hinton, D. S. Millington, T. A. Dourdeville, and C. A. Slaughter. “Analysis of phenylthiohydantoin amino acid mixtures for sequencing by thermospray liquid chromatography/mass spectrometry.” Anal Biochem 175, no. 1 (November 15, 1988): 305–18. https://doi.org/10.1016/0003-2697(88)90394-6.
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    • Pinkston, J. D., G. D. Owens, L. J. Burkes, T. E. Delaney, D. S. Millington, and D. A. Maltby. “Capillary Supercritical Fluid Chromatography—Mass Spectrometry Using A “High Mass” Quadrupole and Splitless Injection.” Analytical Chemistry 60, no. 10 (May 1, 1988): 962–66. https://doi.org/10.1021/ac00161a003.
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    • Dietrich, A. M., D. S. Millington, and Y. H. Seo. “Specific identification of synthetic organic chemicals in river water using liquid-liquid extraction and resin adsorption coupled with electron impact, chemical ionization and accurate mass measurement gas chromatography-mass spectrometry analyses.” Journal of Chromatography A 436, no. C (January 1, 1988): 229–41. https://doi.org/10.1016/S0021-9673(00)94581-3.
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    • Kramer, S. P., J. L. Johnson, A. A. Ribeiro, D. S. Millington, and K. V. Rajagopalan. “The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase.” J Biol Chem 262, no. 34 (December 5, 1987): 16357–63.
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    • Millington, D. S., C. R. Roe, and D. A. Maltby. “Characterization of new diagnostic acylcarnitines in patients with beta-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry.” Biomed Environ Mass Spectrom 14, no. 12 (December 1987): 711–16. https://doi.org/10.1002/bms.1200141204.
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    • Matchar, D. B., J. R. Feussner, D. S. Millington, R. H. Wilkinson, D. J. Watson, and D. Gale. “Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation.” Ann Intern Med 106, no. 5 (May 1987): 707–10. https://doi.org/10.7326/0003-4819-106-5-707.
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    • Roe, C. R., D. S. Millington, D. A. Maltby, and R. B. Wellman. “Post-mortem recognition of inherited metabolic disorders from specific acylcarnitines in tissue in cases of sudden infant death.” Lancet 1, no. 8531 (February 28, 1987): 512. https://doi.org/10.1016/s0140-6736(87)92126-x.
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    • Frimmel, F. H., D. S. Millington, and R. F. Christman. “Quantitative determination of organic compounds in extracts of activated carbon by means of GC/MS.” Fresenius’ Zeitschrift Für Analytische Chemie 327, no. 2 (January 1, 1987): 149–53. https://doi.org/10.1007/BF00469808.
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    • Millington, D. S., C. R. Roe, D. A. Maltby, and F. Inoue. “Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia.” J Pediatr 110, no. 1 (January 1987): 56–60. https://doi.org/10.1016/s0022-3476(87)80288-3.
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    • Gaskell, S. J., C. Guenat, D. S. Millington, D. A. Maltby, and C. R. Roe. “Differentiation of isomeric acylcarnitines using tandem mass spectrometry.” Anal Chem 58, no. 13 (November 1986): 2801–5. https://doi.org/10.1021/ac00126a048.
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    • Dietrich, A. M., D. L. Gallagher, P. M. Derosa, D. S. Millington, and F. A. Digiano. “Enhancement of N-nitrosamine formation on granular-activated carbon from N-methylaniline and nitrite.” Environ Sci Technol 20, no. 10 (October 1, 1986): 1050–55. https://doi.org/10.1021/es00152a016.
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    • Roe, C. R., D. S. Millington, and D. A. Maltby. “Identification of 3-methylglutarylcarnitine. A new diagnostic metabolite of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency.” J Clin Invest 77, no. 4 (April 1986): 1391–94. https://doi.org/10.1172/JCI112446.
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    • Maltby, D. A., and D. S. Millington. “Analysis of volatile free fatty acids in human urine by capillary column gas chromatography/mass spectrometry.” Clin Chim Acta 155, no. 2 (March 16, 1986): 167–72. https://doi.org/10.1016/0009-8981(86)90279-2.
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    • Millington, D. S., D. A. Maltby, and C. R. Roe. “Rapid detection of argininosuccinic aciduria and citrullinuria by fast atom bombardment and tandem mass spectrometry.” Clin Chim Acta 155, no. 2 (March 16, 1986): 173–78. https://doi.org/10.1016/0009-8981(86)90280-9.
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    • Coleman, R. A., J. P. Walsh, D. S. Millington, and D. A. Maltby. “Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver.” J Lipid Res 27, no. 2 (February 1986): 158–65.
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    • Roe, C. R., D. S. Millington, D. A. Maltby, and P. Kinnebrew. “Recognition of medium-chain acyl-CoA dehydrogenase deficiency in asymptomatic siblings of children dying of sudden infant death or Reye-like syndromes.” J Pediatr 108, no. 1 (January 1986): 13–18. https://doi.org/10.1016/s0022-3476(86)80762-4.
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    • Szakál-Quin, G., D. G. Graham, D. S. Millington, D. A. Maltby, and A. T. McPhail. “Stereoisomer Effects on the Paal-Knorr Synthesis of Pyrroles.” Journal of Organic Chemistry 51, no. 5 (January 1, 1986): 621–24. https://doi.org/10.1021/jo00355a010.
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    • Gray, T. K., D. S. Millington, D. A. Maltby, M. E. Williams, M. S. Cohen, and R. C. Dodd. “Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a metabolite that may induce differentiation of the human monoblastic cell line U937.” Proc Natl Acad Sci U S A 82, no. 23 (December 1985): 8218–21. https://doi.org/10.1073/pnas.82.23.8218.
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    • Roe, C. R., D. S. Millington, D. A. Maltby, T. P. Bohan, S. G. Kahler, and R. A. Chalmers. “Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency.” Pediatr Res 19, no. 5 (May 1985): 459–66. https://doi.org/10.1203/00006450-198505000-00011.
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    • Millington, D. S., T. P. Bohan, C. R. Roe, A. L. Yergey, and D. J. Liberato. “Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry.” Clin Chim Acta 145, no. 1 (January 15, 1985): 69–76. https://doi.org/10.1016/0009-8981(85)90020-8.
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    • Utterback, D. F., A. Gold, and D. S. Millington. “QUANTITATIVE ANALYSIS OF FORMALDEHYDE CONDENSATES IN THE VAPOR STATE.” Advances in Chemistry Series, January 1, 1985, 57–65. https://doi.org/10.1021/ba-1985-0210.ch005.
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    • Dietrich, A. M., Y. H. Seo, D. Cutugno, and D. S. Millington. “QUALITATIVE AND QUANTITATIVE ANALYSIS OF SYNTHETIC ORGANIC POLLUTANTS IN RIVER WATER BY GC/MS.” Annual Conference on Mass Spectrometry and Allied Topics, December 1, 1984, 259–60.
    • Gold, A., D. F. Utterback, and D. S. Millington. “Quantitative analysis of gas-phase formaldehyde molecular species at equilibrium with formalin solution.” Anal Chem 56, no. 14 (December 1984): 2879–82. https://doi.org/10.1021/ac00278a058.
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    • Liberato, D. J., A. L. Yergey, and D. S. Millington. “IDENTIFICATION AND QUANTITATIVE ANALYSIS OF ACYLCARNITINES IN HUMAN URINE BY THERMOSPRAY HPLC/MS.” Annual Conference on Mass Spectrometry and Allied Topics, December 1, 1984, 76–77.
    • Maltby, D. A., D. S. Millington, and C. R. Roe. “GC/MS ANALYSIS OF FREE SHORT CHAIN CARBOXYLIC ACIDS BY ON-COLUMN INJECTION ON A FUSED SILICA CAPILLARY COLUMN.” Annual Conference on Mass Spectrometry and Allied Topics, December 1, 1984, 583–84.
    • Millington, D. S., and D. A. Maltby. “CHARACTERIZATION OF COENZYME A AND ITS ACYL DERIVATIVES BY FAB-MS/MS.” Annual Conference on Mass Spectrometry and Allied Topics, December 1, 1984, 398–99.
    • Roe, C. R., D. S. Millington, D. A. Maltby, S. G. Kahler, and T. P. Bohan. “L-carnitine therapy in isovaleric acidemia.” J Clin Invest 74, no. 6 (December 1984): 2290–95. https://doi.org/10.1172/JCI111657.
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    • Roe, C. R., D. S. Millington, D. A. Maltby, T. P. Bohan, and C. L. Hoppel. “L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia.” J Clin Invest 73, no. 6 (June 1984): 1785–88. https://doi.org/10.1172/JCI111387.
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    • Yergey, A. L., D. J. Liberato, and D. S. Millington. “Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives.” Anal Biochem 139, no. 2 (June 1984): 278–83. https://doi.org/10.1016/0003-2697(84)90003-4.
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    • Millington, D. S., C. R. Roe, and D. A. Maltby. “Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease.” Biomed Mass Spectrom 11, no. 5 (May 1984): 236–41. https://doi.org/10.1002/bms.1200110508.
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    • Chalmers, R. A., T. E. Stacey, B. M. Tracey, C. de Sousa, C. R. Roe, D. S. Millington, and C. L. Hoppel. “L-Carnitine insufficiency in disorders of organic acid metabolism: response to L-carnitine by patients with methylmalonic aciduria and 3-hydroxy-3-methylglutaric aciduria.” J Inherit Metab Dis 7 Suppl 2 (1984): 109–10. https://doi.org/10.1007/978-94-009-5612-4_29.
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    • Utterback, D. F., A. Gold, and D. S. Millington. “FORMALDEHYDE CONDENSATION PRODUCTS IN THE GAS PHASE.” National Meeting  American Chemical Society, Division of Environmental Chemistry 24, no. 1 (January 1, 1984): 78–81.
    • Utterback, D. F., D. S. Millington, and A. Gold. “Characterization and Determination of Formaldehyde Oligomers by Capillary Column Gas Chromatography.” Analytical Chemistry 56, no. 3 (January 1, 1984): 470–73. https://doi.org/10.1021/ac00267a040.
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    • Colclough, C. A., D. J. Johnson, R. F. Christman, and D. S. Millington. “ORGANIC REACTION PRODUCTS OF CHLORINE DIOXIDE AND NATURAL AQUATIC FULVIC ACIDS.” Water Chlorination: Environmental Impact and Health Effects 4, no. nook 1 (December 1, 1983): 219–29.
    • Dietrich, A. M., P. DeRosa, D. Gallagher, D. S. Millington, and F. A. DiGiano. “ENHANCEMENT OF N-NITROSAMINE FORMATION ON GRANULAR ACTIVATED CARBON FROM N-METHYL ANILINE.” National Meeting  American Chemical Society, Division of Environmental Chemistry 23, no. 2 (December 1, 1983): 382–83.
    • Millington, D. S., C. R. Roe, and D. A. Maltby. “CHARACTERIZATION AND ANALYSIS OF ACYLCARNITINES BY FAB AND B/E LINKED SCANNING: APPLICATION TO METABOLIC DISEASE.” Annual Conference on Mass Spectrometry and Allied Topics, December 1, 1983, 361–62.
    • Millington, D. S., D. J. Bertino, T. Kamei, and R. F. Christman. “ANALYSIS OF ORGANIC COMPOUNDS ADSORBED ON GRANULAR ACTIVATED CARBON FILTERS USED IN TREATMENT PLANTS.” Water Chlorination: Environmental Impact and Health Effects 4, no. nook 1 (December 1, 1983): 445–54.
    • Millington, D. S., D. Utterback, and A. R. Gold. “CHARACTERIZATION OF FORMALDEHYDE OLIGOMERS BY CAPILLARY GC/AMMONIA CI.” Annual Conference on Mass Spectrometry and Allied Topics, December 1, 1983, 229–30.
    • Millington, D. S., T. Kamei, D. Bertino, and D. Maltby. “ANALYSIS OF ORGANIC MATERIAL ACCUMULATED ON GRANULAR ACTIVATED CARBON FILTERS USED IN DRINKING WATER TREATMENT.” Annual Conference on Mass Spectrometry and Allied Topics, December 1, 1983, 460.
    • Norwood, D. L., D. J. Johnson, R. F. Christman, and D. S. Millington. “CHLORINATION PRODUCTS FROM AQUATIC HUMIC MATERIAL AT NEUTRAL pH.” Water Chlorination: Environmental Impact and Health Effects 4, no. nook 1 (December 1, 1983): 191–200.
    • Norwood, D. L., G. P. Thompson, J. J. St. Aubin, D. S. Millington, R. F. Christman, and J. D. Johnson. “BY-PRODUCTS OF CHLORINATION: SPECIFIC COMPOUNDS AND THEIR RELATIONSHIP TO TOTAL ORGANIC HALOGEN.” National Meeting  American Chemical Society, Division of Environmental Chemistry 23, no. 2 (December 1, 1983): 65–68.
    • Roe, C. R., C. L. Hoppel, T. E. Stacey, R. A. Chalmers, B. M. Tracey, and D. S. Millington. “Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups.” Arch Dis Child 58, no. 11 (November 1983): 916–20. https://doi.org/10.1136/adc.58.11.916.
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    • Christman, R. F., D. L. Norwood, D. S. Millington, J. D. Johnson, and A. A. Stevens. “Identity and yields of major halogenated products of aquatic fulvic acid chlorination.” Environ Sci Technol 17, no. 10 (October 1, 1983): 625–28. https://doi.org/10.1021/es00116a012.
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    • Dietrich, A. M., D. S. Millington, and R. F. Christman. “SPECIFIC IDENTIFICATION OF ORGANIC POLLUTANTS IN HAW RIVER WATER USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY.” Report  Water Resources Research Institute of the University of North Carolina, no. 206 (August 1, 1983).
    • Dietrich, A. M., D. S. Millington, and R. F. Christman. “SPECIFIC IDENTIFICATION OF ORGANIC POLLUTANTS IN HAW RIVER WATER USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY.” Report  Water Resources Research Institute of the University of North Carolina, no. 206 (January 1, 1983).
    • Johnson, J. D., R. F. Christman, D. L. Norwood, and D. S. Millington. “Reaction products of aquatic humic substances with chlorine.” Environ Health Perspect 46 (December 1982): 63–71. https://doi.org/10.1289/ehp.824663.
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    • Liao, W., R. F. Christman, J. D. Johnson, D. S. Millington, and J. R. Hass. “Structural characterization of aquatic humic material.” Environ Sci Technol 16, no. 7 (July 1, 1982): 403–10. https://doi.org/10.1021/es00101a007.
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    • Pandey, R. C., K. L. Rinehart, and D. S. Millington. “The structures of dermostatins A and B 1,2.” Hindustan Antibiot Bull 22, no. 3–4 (1980): 47–61.
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    • Gaskell, S. J., A. W. Pike, and D. S. Millington. “The fragmentation of stereoisomeric androstanediol t‐butyldimethylsilyl ethers. A study by linked field scanning.” Biological Mass Spectrometry 6, no. 2 (January 1, 1979): 78–81. https://doi.org/10.1002/bms.1200060208.
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    • Gaskell, S. J., and D. S. Millington. “Selected metastable peak monitoring: a new specific technique in quantitative gas chromatography mass spectrometry.” Biomed Mass Spectrom 5, no. 9 (September 1978): 557–58. https://doi.org/10.1002/bms.1200050910.
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    • Millington, D. S. “New techniques in quantitative mass spectrometry.” J Reprod Fertil 51, no. 1 (September 1977): 303–8. https://doi.org/10.1530/jrf.0.0510303.
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    • Liesch, J. M., D. S. Millington, R. C. Pandey, and K. L. Rinehart. “Berninamycin. 2. Products of acidic hydrolysis, methanolysis, and acetolysis of berninamycin A1.” J Am Chem Soc 98, no. 25 (December 8, 1976): 8237–49. https://doi.org/10.1021/ja00441a058.
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    • Millington, D. S., M. P. Golder, T. Cowley, D. London, H. Roberts, W. R. Butt, and K. Griffiths. “In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones.” Acta Endocrinol (Copenh) 82, no. 3 (July 1976): 561–71. https://doi.org/10.1530/acta.0.0820561.
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    • Golder, M. P., D. S. Millington, T. H. Cowley, K. Griffiths, H. Roberts, D. R. London, and W. R. Butt. “Proceedings: Hormonal control of steroid synthesis by a feminizing adrenal tumour.” J Endocrinol 67, no. 2 (November 1975): 17P.
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    • Millington, D. S. “Determination of hormonal steroid concentrations in biological extracts by high resolution mass fragmentography.” J Steroid Biochem 6, no. 3–4 (1975): 239–45. https://doi.org/10.1016/0022-4731(75)90139-9.
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    • Millington, D. S., M. E. Buoy, G. Brooks, M. E. Harper, and K. Griffiths. “Thin‐layer chromatography and high resolution selected ion monitoring for the analysis of C19 steroids in human hyperplastic prostate tissue.” Biological Mass Spectrometry 2, no. 4 (January 1, 1975): 219–24. https://doi.org/10.1002/bms.1200020411.
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    • Games, D. E., A. H. Jackson, N. A. Khan, and D. S. Millington. “Alkaloids of some African, Asian, Polynesian and Australian species of Erythrina.” Lloydia 37, no. 4 (December 1974): 581–88.
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    • Hargreaves, R. T., R. D. Johnson, D. S. Millington, M. H. Mondal, W. Beavers, L. Becker, C. Young, and K. L. Rinehart. “Alkaloids of American species of Erythrina.” Lloydia 37, no. 4 (December 1974): 569–80.
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    • Millington, D. S., T. Jones, D. Jenner, and K. Griffiths. “Proceedings: Measurement of endogenous steroid levels in human breast tumours by mass fragmentography.” J Endocrinol 61, no. 2 (May 1974): LIV–LV.
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    • Millington, D. S., D. H. Steinman, and K. L. Rinehart. “Isolation, gas chromatography-mass spectrometry, and structures of new alkaloids from Erythrina folkersii Krukoff and Moldenke and Erythrina salviiflora Krukoff and Barneby.” J Am Chem Soc 96, no. 6 (March 20, 1974): 1909–17. https://doi.org/10.1021/ja00813a043.
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    • Games, D. E., A. H. Jackson, D. S. Millington, and M. Rossiter. “The field ionization spectra of some natural coumarins.” Biomed Mass Spectrom 1, no. 1 (February 1974): 5–9. https://doi.org/10.1002/bms.1200010104.
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    • Pandey, R. C., K. L. Rinehart, D. S. Millington, and M. B. Swami. “Letter: Polyene antibiotics. VI. The structures of dermostatins A and B.” J Antibiot (Tokyo) 26, no. 8 (August 1973): 475–77. https://doi.org/10.7164/antibiotics.26.475.
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    • Stoll, M. S., G. H. Elder, D. E. Games, P. O’Hanlon, D. S. Millington, and A. H. Jackson. “Isocoproporphyrin: nuclear-magnetic-resonance-and mass-spectral methods for the determination of porphyrin structure.” Biochem J 131, no. 2 (February 1973): 429–32. https://doi.org/10.1042/bj1310429.
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    • Pandey, R. C., N. Narasimhachari, K. L. Rinehart, and D. S. Millington. “Polyene antibiotics. IV. Structure of chainin.” J Am Chem Soc 94, no. 12 (June 14, 1972): 4306–10. https://doi.org/10.1021/ja00767a045.
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    • Agarwal, K. L., R. A. Johnstone, G. W. Kenner, D. S. Millington, and R. C. Sheppard. “Mass spectrometry of N-methylated peptide derivatives.” Nature 219, no. 5153 (August 3, 1968): 498–99. https://doi.org/10.1038/219498a0.
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  • Book Sections

    • Millington, D. S. “Mass spectrometry.” In Encyclopedia of Analytical Science, 437–42, 2019. https://doi.org/10.1016/B978-0-12-409547-2.14534-2.
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    • Norwood, D. L., G. P. Thompson, J. J. S. Aubin, D. S. Millington, R. F. Christman, and J. D. Johnson. “By-products of chlorination: Specific compounds and their relationship to total organic halogen.” In Safe Drinking Water: The Impact of Chemicals on a Limited Resource, 109–21, 2017.
    • Chien, Yin-Hsiu, Jennifer L. Goldstein, Wuh-Liang Hwu, P Brian Smith, Ni-Chung Lee, Shu-Chuan Chiang, Adviye A. Tolun, et al. “Baseline Urinary Glucose Tetrasaccharide Concentrations in Patients with Infantile- and Late-Onset Pompe Disease Identified by Newborn Screening.,” 19:67–73, 2015. https://doi.org/10.1007/8904_2014_366.
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    • Millington, D. S., R. Sista, D. Bali, A. E. Eckhardt, and V. Pamula. “Development of Biomarker Assays for Clinical Diagnostics Using a Digital Microfluidics Platform.” In Dried Blood Spots: Applications and Techniques, 9781118054697:325–31, 2014. https://doi.org/10.1002/9781118890837.ch25.
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    • Millington, D. S., H. Zhang, M. Arthur Moseley, J. Will Thompson, and P. Smith. “Direct Solvent Extraction and Analysis of Biomarkers in Dried Blood Spots Using a Flow-Through Autosampler.” In Dried Blood Spots: Applications and Techniques, 9781118054697:314–24, 2014. https://doi.org/10.1002/9781118890837.ch24.
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    • Koeberl, D. D., S. Young, D. Millington, and G. K. Klintworth. “Disorders of amino acid metabolism.” In Garner and Klintworth’s Pathobiology of Ocular Disease Part B, Third Edition, 953–82, 2007.

  • Conference Papers

    • Zhang, Haoyue, Patricia I. Dickson, Agnes H. Chen, Marla Weetall, Steven Q. Le, David S. Millington, and Sarah P. Young. “Quantification of dermatan sulfate and heparan sulfate in cerebrospinal fluid using liquid chromatography-tandem mass spectrometry for therapeutic monitoring of patients with mucopolysaccharidoses.” In Molecular Genetics and Metabolism, 117:S123–S123. Elsevier BV, 2016. https://doi.org/10.1016/j.ymgme.2015.12.494.
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    • Rubach, Matthew P., Salvatore Florence, Haoyue Zhang, Nicholas M. Anstey, Tsin W. Yeo, David S. Millington, J Brice Weinberg, Esther D. Mwaikambo, and Donald L. Granger. “INCREASED TOTAL BODY ARGININE FLUX AND DECREASED NITRIC OXIDE SYNTHESIS IN SEVERE FALCIPARUM MALARIA.” In American Journal of Tropical Medicine and Hygiene, 93:189–189. AMER SOC TROP MED & HYGIENE, 2015.
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    • Mori, Mad, Jennifer L. Goldstein, Sarah P. Young, David S. Millington, and Dwight D. Koeberl. “A family with X-linked creatine transporter deficiency diagnosed by whole exome sequencing.” In Molecular Genetics and Metabolism, 114:344–45. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015.
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    • Ulla, Anirudh J., Deeksha Bali, Tim Wood, and David S. Millington. “DRIED BLOOD SPOT ENZYMATIC ASSAYS FOR MPS TYPE IVA (MORQUIO) AND TYPE VI (MAROTEAUX-LAMY) SYNDROMES.” In Molecular Genetics and Metabolism, 111:251–251. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2014.
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    • Ullal, Anirudh J., David S. Millington, Timothy C. Wood, and Deeksha Bali. “The development and validation of dried blood spot enzymatic assays for MPS type IV A (Morquio) and type VI (Maroteaux-Lamy) syndromes.” In Molecular Genetics and Metabolism, 111:S106–S106. Elsevier BV, 2014. https://doi.org/10.1016/j.ymgme.2013.12.263.
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    • Young, Sarah P., Haoyue Zhang, Michelle Canfield, Arnie Vaisnins-Carroll, Christiane Auray-Blais, Marie McDonald, and David S. Millington. “Assessment of urinary globotriaosylsphingosine (lyso-Gb(3)), globotriaosylceramide (gb(3)) by LC-MS/MS in patients with fabry disease.” In Molecular Genetics and Metabolism, 105:364–65. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012.
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    • Zhang, Haoyue, Tim Wood, Haiyan Fu, Christiane Auray-Blais, Sarah P. Young, Dwight Koeberl, and David S. Millington. “Quantification of glycosaminoglycans in human urine and mouse tissue by UPLC-MS/MS.” In Molecular Genetics and Metabolism, 105:365–66. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012.
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    • Clark, Paul J., Alexander J. Thompson, David M. Vock, Lisa E. Kratz, Adviye A. Tolun, Hao Yue Zhang, Andrew J. Muir, et al. “METABOLOMIC ANALYSIS DEMONSTRATES HEPATITIS C VIRUS GENOTYPES G2/3 SELECTIVELY PERTURB DISTAL STEPS IN CHOLESTEROL BIOSYNTHESIS.” In Hepatology, 54:1333A-1333A. WILEY-BLACKWELL, 2011.
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    • Auray-Blais, Christiane, Paméla Lavoie, René Gagnon, Joe T. R. Clarke, Yan An, Sarah P. Young, Haoyue Zhang, and David S. Millington. “Efficient urine filter paper mass spectrometry methodology for glycosaminoglycan quantification.” In Molecular Genetics and Metabolism, 102:S5–6. Elsevier BV, 2011. https://doi.org/10.1016/j.ymgme.2010.11.017.
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    • Auray-Blais, C., P. Lavoie, R. Gagnon, J. T. R. Clarke, B. Maranda, Y. An, S. P. Young, H. Zhang, and D. S. Millington. “GLYCOSAMINOGLYCAN QUANTIFICATION BY LC/MS-MS FOR MUCOPOLYSACCHARIDOSES.” In Journal of Inherited Metabolic Disease, 34:S217–S217. SPRINGER, 2011.
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    • Dessein, A. F., M. Fontaine, B. S. Andresen, N. Gregersen, M. Brivet, D. Rabier, S. Napuri-Gouel, et al. “MILD MCAD MAY ALSO BE DIAGNOSED BY MEASURING WHOLE BLOOD ACYLCARNITINE PRODUCTION RATES GENERATED FROM DEUTERATED PALMITATE.” In Journal of Inherited Metabolic Disease, 33:S80–S80. SPRINGER, 2010.
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    • Auray-Blais, Christiane, Patrick Bhérer, René Gagnon, Joe T. R. Clarke, Haoyue Zhang, Yan An, Sarah P. Young, and David S. Millington. “7. A urinary glycosaminoglycan analysis by tandem mass spectrometry.” In Molecular Genetics and Metabolism, 99:S9–S9. Elsevier BV, 2010. https://doi.org/10.1016/j.ymgme.2009.10.024.
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    • Auray-Blais, Christiane, René Gagnon, David G. Warnock, Sarah P. Young, David S. Millington, and Joe T. R. Clarke. “8. How useful is urinary lyso-Gb3 as a biomarker for Fabry disease?” In Molecular Genetics and Metabolism, 99:S9–S9. Elsevier BV, 2010. https://doi.org/10.1016/j.ymgme.2009.10.025.
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    • Auray-Blais, Christiane, Rene Gagnon, Joe T. R. Clarke, Sarah P. Young, and David S. Millington. “METABOLOMICS, BIOMARKER DISCOVERY AND FABRY DISEASE: AN EFFICIENT PLATFORM IS NECESSARY!.” In Clinical Therapeutics, 32:S112–S112. ELSEVIER, 2010.
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    • Goldstein, J. L., S. P. Young, M. Changela, G. H. Dickerson, H. Zhang, J. Dai, D. Peterson, D. S. Millington, P. S. Kishnani, and D. S. Bali. “LABORATORY EXPERIENCE OF USING DRIED BLOOD SPOT ASSAY TO DIAGNOSE POMPE DISEASE.” In Muscle & Nerve, 40:708–9. JOHN WILEY & SONS INC, 2009.
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    • Jimenez-Sanchez, G., I. Silva-Zolezzi, G. Thomas, D. S. Millington, and D. Valle. “Partial phenotypic correction of the 70kDa peroxisomal membrane protein (PMP70) deficient mouse by making it PPAR alpha deficient.” In American Journal of Human Genetics, 71:195–195. UNIV CHICAGO PRESS, 2002.
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    • Silva-Zolezzi, I., K. J. Hebron, G. Thomas, D. S. Millington, V. Valle, and G. Jimenez-Sanchez. “Impaired fuel homeostasis leads to defective non-shivering thermogenesis in the 70kDa Peroxisomal Membrane Protein (PMP70) deficient mouse.” In American Journal of Human Genetics, 71:541–541. UNIV CHICAGO PRESS, 2002.
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    • An, Y., D. S. Millington, P. Kishnani, A. Amalfitano, and Y. T. Chen. “Validation of glucose tetrasaccharide as a biomarker for diagnosis and mornitoring enzyme replacement therapy for Pompe disease.” In American Journal of Human Genetics, 69:482–482. UNIV CHICAGO PRESS, 2001.
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    • Muenzer, J., D. M. Frazier, S. D. Weavil, D. S. Millington, E. G. Moore, S. W. Burton, C. A. Currie, and S. H. Chaing. “Incidence of metabolic disorders detected by newborn screening in North Carolina using tandem mass spectrometry.” In American Journal of Human Genetics, 67:36–36. UNIV CHICAGO PRESS, 2000.
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    • DIONSIVICI, C., B. GARAVAGLIA, A. BARTULI, F. INVERNIZZI, S. DIDONATO, G. SABETTA, S. G. KAHLER, and D. S. MILLINGTON. “CARNITINE ACYLCARNITINE TRANSLOCASE DEFICIENCY - BENIGN COURSE WITHOUT CARDIAC INVOLVEMENT.” In Pediatric Research, 37:A147–A147. WILLIAMS & WILKINS, 1995.
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    • CHACE, D. H., and D. S. MILLINGTON. “NEONATAL SCREENING FOR INBORN-ERRORS OF METABOLISM BY AUTOMATED DYNAMIC LIQUID SECONDARY-ION TANDEM MASS-SPECTROMETRY.” In New Horizons in Neonatal Screening, edited by J. P. Farriaux and J. L. Dhondt, 1041:373–76. ELSEVIER SCIENCE PUBL B V, 1994.
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    • MATCHAR, D. B., J. R. FEUSSNER, D. J. WATSON, R. H. WILKINSON, and D. S. MILLINGTON. “URINARY METHYLMALONIC ACID ASSAY IN THE DIAGNOSIS OF VITAMIN-B12 DEFICIENCY - THE GOLD STANDARD.” In Clinical Research, 34:A376–A376. SLACK INC, 1986.
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    • MATCHAR, D. B., J. R. FEUSSNER, D. J. WATSON, R. H. WILKINSON, D. S. MILLINGTON, and D. GALE. “URINARY METHYLMALONIC ACID ASSAY IN THE DIAGNOSIS OF VITAMIN-B12 DEFICIENCY - THE GOLD STANDARD.” In Clinical Research, 34:A271–A271. SLACK INC, 1986.
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    • SCHEINMAN, J. I., D. S. MILLINGTON, D. A. GALE, and C. ROE. “ASSAY FOR URINE AND PLASMA OXALATE BY GC/MS ISOTOPE-DILUTION.” In Kidney International, 29:202–202. BLACKWELL SCIENCE INC, 1986.
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    • MATCHAR, D. B., J. R. FEUSSNER, D. J. WATSON, J. WILKINSON, D. S. MILLINGTON, and D. GALE. “LOW SERUM VITAMIN-B12 LEVELS - DO THEY DENOTE DEFICIENCY.” In Clinical Research, 33:A727–A727. SLACK INC, 1985.
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    • SCHEINMAN, J. I., D. GALE, C. R. ROE, and D. S. MILLINGTON. “RELIABLE MEASUREMENT OF URINE AND PLASMA OXALATE BY GC/MS.” In Kidney International, 27:126–126. BLACKWELL SCIENCE INC, 1985.
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