David Stuart Millington | Scholars@Duke

David Stuart Millington
Professor Emeritus of Pediatrics

Development of new mass spectrometric methods for the analysis of disease-specific metabolites in human physiological fluids for application to the diagnosis of inborn errors of metabolism. The development of automated methods based on tandem mass spectrometry for the analysis of these metabolites in blood spots and urine from neonates, with a view to revolutionizing newborn screening methodology.
Development and application of mass spectrometry based biomarker assays for monitoring treatment and diagnosis of lysosomal storage diseases (LSDs).
Development and application of methods for analysis of drugs used in human clinical trials.
Application of "lab-on-a-chip" technology, based on digital microfluidics, to enzymatic and DNA- based assays used in newborn screening and at the point of care.
Development and application of new methods for studing clucose metabolism both in vivo and in vitro using stable isotope labeling with tandem mass spectrometry.
Development and application of methods for the analysis of urine markers of oxidative stress, using tandem mass spectrometry.

Current Appointments & Affiliations

Professor Emeritus of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 2015

Contact Information

801-6 Capitola Drive, Box 103856, Durham, NC 27713
Box 3028 Med Ctr, Durham, NC 27710
milli014@duke.edu (919) 684-0757

Background
Education, Training, & Certifications
- Ph.D., University of Liverpool 1969
Duke Appointment History
- Professor of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 2006 - 2015
- Research Professor of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 1998 - 2006
- Associate Research Professor of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 1997 - 1998
- Associate Research Professor of Pediatrics, Pediatrics, Clinical Science Departments 1994 - 1997
Research
Selected Grants
- Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia awarded by National Institutes of Health 2011 - 2018
- Dietary therapy in mitochondrial trifunctional protein deficiency awarded by Ultragenyx Pharmaceutical 2014 - 2015
- Development and validation of a UPLC-MS/MS assay for urinary keratan sulfate (uKS) awarded by BioMarin Pharmaceutical, Inc. 2013 - 2015
- Lab on a Chip for Multiplexed Newborn Screening of Lysosomal Storage Disease awarded by Baebies, Inc 2009 - 2015
- Multidisciplinary Neonatal Training Grant awarded by National Institutes of Health 2010 - 2015
- Adoptive Immunotherapy for GBM During Hematopoietic Recovery from Temozolomide awarded by National Institutes of Health 2009 - 2014
- Training course for expanded (MS/MS) newborn screening laboratory follow-up coordinators awarded by Association of Public Health Laboratories 2014
- Urinary F2-isoprostanes as a new biomarker for the risk of type 2 diabetes awarded by National Institutes of Health 2009 - 2013
- Pharmacometabolomics Research Network awarded by National Institutes of Health 2010 - 2011
- Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health 2003 - 2009
- Metabolic Profiling to Identify Alcohol Biomarker Signature awarded by National Institutes of Health 2006 - 2009
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Millington, DS. "The Role of Technology in Newborn Screening." North Carolina Medical Journal 80, no. 1 (January 2019): 49-53. Full Text
  - Millington, D, Norton, S, Singh, R, Sista, R, Srinivasan, V, and Pamula, V. "Digital microfluidics comes of age: high-throughput screening to bedside diagnostic testing for genetic disorders in newborns." Expert Review of Molecular Diagnostics 18, no. 8 (August 2018): 701-712. Full Text
  - Nasca, C, Bigio, B, Lee, FS, Young, SP, Kautz, MM, Albright, A, Beasley, J, Millington, DS, Mathé, AA, Kocsis, JH, Murrough, JW, McEwen, BS, and Rasgon, N. "Acetyl-l-carnitine deficiency in patients with major depressive disorder." Proceedings of the National Academy of Sciences of the United States of America 115, no. 34 (August 2018): 8627-8632. Full Text
  - Pomerantz, DJ, Ferdinandusse, S, Cogan, J, Cooper, DN, Reimschisel, T, Robertson, A, Bican, A, McGregor, T, Gauthier, J, Millington, DS, Andrae, JLW, Tschannen, MR, Helbling, DC, Demos, WM, Denis, S, Wanders, RJA, Newman, JN, Hamid, R, Phillips, JA, and Collaborators of UDN, . "Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant." American Journal of Medical Genetics. Part A 176, no. 3 (March 2018): 692-698. Full Text
  - Millington, DS. "Response to Gelb et al.: "Comparison of tandem mass spectrometry to fluorimetry for newborn screening of LSDs"." Molecular genetics and metabolism reports 12 (September 2017): 98-. (letter) Full Text
  - Millington, DS, and Bali, DM. "Misinformation regarding tandem mass spectrometric vs fluorometric assays to screen newborns for LSDs." Molecular Genetics and Metabolism Reports 11 (June 2017): 72-73. (Letter) Full Text
  - Peake, RWA, Marsden, DL, Bodamer, OA, Gelb, MH, Millington, DS, and Wijburg, F. "Newborn Screening for Lysosomal Storage Disorders: Quo Vadis?." Clinical Chemistry 62, no. 11 (November 2016): 1430-1438. Full Text
  - Sampat, R, Young, S, Rosen, A, Bernhard, D, Millington, D, Factor, S, and Jinnah, HA. "Potential mechanisms for low uric acid in Parkinson disease." Journal of neural transmission (Vienna, Austria : 1996) 123, no. 4 (April 2016): 365-370. Full Text
  - Ledford, CK, Butler, RJ, Queen, RM, and Bolognesi, MP. "In reply." The Journal of arthroplasty 30, no. 5 (May 2015): 896-. (Letter) Full Text
  - Zhang, H, Wood, T, Young, SP, and Millington, DS. "A straightforward, quantitative ultra-performance liquid chromatography-tandem mass spectrometric method for heparan sulfate, dermatan sulfate and chondroitin sulfate in urine: an improved clinical screening test for the mucopolysaccharidoses." Molecular Genetics and Metabolism 114, no. 2 (February 2015): 123-128. Full Text
  - Houten, SM, Denis, S, Te Brinke, H, Jongejan, A, van Kampen, AHC, Bradley, EJ, Baas, F, Hennekam, RCM, Millington, DS, Young, SP, Frazier, DM, Gucsavas-Calikoglu, M, and Wanders, RJA. "Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia." Human molecular genetics 23, no. 18 (September 2014): 5009-5016. Full Text
  - Ullal, AJ, Millington, DS, and Bali, DS. "Development of a fluorometric microtiter plate based enzyme assay for MPS IVA (Morquio type A) using dried blood spots." Molecular genetics and metabolism reports 1 (January 2014): 461-464. Full Text
  - Ullal, AJ, Millington, DS, and Bali, DS. "Development of a fluorometric microtiter plate-based enzyme assay for arylsulfatase B (MPS VI) using dried blood spots." Molecular genetics and metabolism reports 1 (January 2014): 465-467. Full Text
  - "Novel application of digital microfluidics for the detection of biotinidase deficiency in newborns." Clinical Biochemistry 46, no. 18 (December 1, 2013): 1889-1891. Full Text
  - Graham, C, Sista, RS, Kleinert, J, Wu, N, Eckhardt, A, Bali, D, Millington, DS, and Pamula, VK. "Novel application of digital microfluidics for the detection of biotinidase deficiency in newborns." Clinical Biochemistry 46, no. 18 (December 2013): 1889-1891. Full Text
  - Sista, RS, Wang, T, Wu, N, Graham, C, Eckhardt, A, Winger, T, Srinivasan, V, Bali, D, Millington, DS, and Pamula, VK. "Multiplex newborn screening for Pompe, Fabry, Hunter, Gaucher, and Hurler diseases using a digital microfluidic platform." Clinica Chimica Acta; International Journal of Clinical Chemistry 424 (September 2013): 12-18. Full Text
  - El-Gharbawy, AH, Goldstein, JL, Millington, DS, Vaisnins, AE, Schlune, A, Barshop, BA, Schulze, A, Koeberl, DD, and Young, SP. "Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency." Molecular Genetics and Metabolism 109, no. 2 (June 2013): 215-217. Full Text
  - Sista, RS, Wang, T, Wu, N, Graham, C, Eckhardt, A, Bali, D, Millington, DS, and Pamula, VK. "Rapid assays for Gaucher and Hurler diseases in dried blood spots using digital microfluidics." Molecular Genetics and Metabolism 109, no. 2 (June 2013): 218-220. Full Text
  - El-Gharbawy, AH, Goldstein, JL, Millington, DS, Vaisnins, AE, Schlune, A, Barshop, BA, Schulze, A, Koeberl, DD, and Young, SP. "Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency." Molecular Genetics and Metabolism 109, no. 2 (2013): 215-217. Full Text
  - Sista, RS, Wang, T, Wu, N, Graham, C, Eckhardt, A, Bali, D, Millington, DS, and Pamula, VK. "Rapid assays for Gaucher and Hurler diseases in dried blood spots using digital microfluidics." Molecular Genetics and Metabolism 109, no. 2 (2013): 218-220. Full Text
  - Zhang, H, Young, SP, and Millington, DS. "Quantification of glycosaminoglycans in urine by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry." Curr Protoc Hum Genet Chapter 17 (2013): Unit-17.12. Full Text Link to Item
  - Tolun, AA, Scarbrough, PM, Zhang, H, McKillop, J-A, Wang, F, Kishnani, PS, Millington, DS, Young, SP, and Il'yasova, D. "Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome." Ann Epidemiol 22, no. 12 (December 2012): 892-894. Full Text Link to Item
  - Thompson, JW, Zhang, H, Smith, P, Hillman, S, Moseley, MA, and Millington, DS. "Extraction and analysis of carnitine and acylcarnitines by electrospray ionization tandem mass spectrometry directly from dried blood and plasma spots using a novel autosampler." Rapid Communications in Mass Spectrometry : Rcm 26, no. 21 (November 2012): 2548-2554. Full Text
  - Clark, PJ, Thompson, AJ, Vock, DM, Kratz, LE, Tolun, AA, Muir, AJ, McHutchison, JG, Subramanian, M, Millington, DM, Kelley, RI, and Patel, K. "Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner." Hepatology 56, no. 1 (July 2012): 49-56. Full Text Link to Item
  - Auray-Blais, C, Lavoie, P, Zhang, H, Gagnon, R, Clarke, JTR, Maranda, B, Young, SP, An, Y, and Millington, DS. "An improved method for glycosaminoglycan analysis by LC-MS/MS of urine samples collected on filter paper." Clinica Chimica Acta; International Journal of Clinical Chemistry 413, no. 7-8 (April 2012): 771-778. Full Text
  - Tolun, AA, Graham, C, Shi, Q, Sista, RS, Wang, T, Eckhardt, AE, Pamula, VK, Millington, DS, and Bali, DS. "A novel fluorometric enzyme analysis method for Hunter syndrome using dried blood spots." Molecular Genetics and Metabolism 105, no. 3 (March 2012): 519-521. Full Text
  - Young, SP, Piraud, M, Goldstein, JL, Zhang, H, Rehder, C, Laforet, P, Kishnani, PS, Millington, DS, Bashir, MR, and Bali, DS. "Assessing disease severity in Pompe disease: the roles of a urinary glucose tetrasaccharide biomarker and imaging techniques." Am J Med Genet C Semin Med Genet 160C, no. 1 (February 15, 2012): 50-58. Full Text Link to Item
  - Il'yasova, D, Spasojevic, I, Base, K, Zhang, H, Wang, F, Young, SP, Millington, DS, D'Agostino, RB, and Wagenknecht, LE. "Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes." Diabetes Care 35, no. 1 (January 2012): 173-174. Full Text
  - Sista, RS, Eckhardt, AE, Wang, T, Graham, C, Rouse, JL, Norton, SM, Srinivasan, V, Pollack, MG, Tolun, AA, Bali, D, Millington, DS, and Pamula, VK. "Digital microfluidic platform for multiplexing enzyme assays: implications for lysosomal storage disease screening in newborns." Clinical Chemistry 57, no. 10 (October 2011): 1444-1451. Full Text
  - Zhang, H, Young, SP, Auray-Blais, C, Orchard, PJ, Tolar, J, and Millington, DS. "Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry." Clinical Chemistry 57, no. 7 (July 2011): 1005-1012. Full Text
  - Auray-Blais, C, Bhérer, P, Gagnon, R, Young, SP, Zhang, HH, An, Y, Clarke, JTR, and Millington, DS. "Efficient analysis of urinary glycosaminoglycans by LC-MS/MS in mucopolysaccharidoses type I, II and VI." Mol Genet Metab 102, no. 1 (January 2011): 49-56. Full Text Link to Item
  - Il'yasova, D, Kennedy, K, Spasojevic, I, Wang, F, Tolun, AA, Base, K, Young, SP, Kelly Marcom, P, Marks, J, Millington, DS, and Dewhirst, MW. "Individual responses to chemotherapy-induced oxidative stress." Breast Cancer Research and Treatment 125, no. 2 (January 2011): 583-589. Full Text
  - Millington, DS, and Stevens, RD. "Acylcarnitines: analysis in plasma and whole blood using tandem mass spectrometry." Methods Mol Biol 708 (2011): 55-72. Full Text Link to Item
  - Auray-Blais, C, Ntwari, A, Clarke, JTR, Warnock, DG, Oliveira, JP, Young, SP, Millington, DS, Bichet, DG, Sirrs, S, West, ML, Casey, R, Hwu, W-L, Keutzer, JM, Zhang, XK, and Gagnon, R. "How well does urinary lyso-Gb3 function as a biomarker in Fabry disease?." Clinica Chimica Acta; International Journal of Clinical Chemistry 411, no. 23-24 (December 2010): 1906-1914. Full Text
  - Dessein, A-F, Fontaine, M, Andresen, BS, Gregersen, N, Brivet, M, Rabier, D, Napuri-Gouel, S, Dobbelaere, D, Mention-Mulliez, K, Martin-Ponthieu, A, Briand, G, Millington, DS, Vianey-Saban, C, Wanders, RJA, and Vamecq, J. "A novel mutation of the ACADM gene (c.145C>G) associated with the common c.985A>G mutation on the other ACADM allele causes mild MCAD deficiency: a case report. (Published online)" Orphanet J Rare Dis 5 (October 5, 2010): 26-. Full Text Open Access Copy Link to Item
  - Tolun, AA, Zhang, H, Il'yasova, D, Sztáray, J, Young, SP, and Millington, DS. "Allantoin in human urine quantified by ultra-performance liquid chromatography-tandem mass spectrometry." Analytical Biochemistry 402, no. 2 (July 2010): 191-193. Full Text
  - Il'yasova, D, Spasojevic, I, Wang, F, Tolun, AA, Base, K, Young, SP, Marcom, PK, Marks, J, Mixon, G, DiGiulio, R, and Millington, DS. "Urinary biomarkers of oxidative status in a clinical model of oxidative assault." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 19, no. 6 (June 2010): 1506-1510. Full Text
  - Millington, DS, Sista, R, Eckhardt, A, Rouse, J, Bali, D, Goldberg, R, Cotten, M, Buckley, R, and Pamula, V. "Digital microfluidics: a future technology in the newborn screening laboratory?." Seminars in Perinatology 34, no. 2 (April 2010): 163-169. Full Text
  - Zhang, H, Il'yasova, D, Sztaray, J, Young, SP, Wang, F, and Millington, DS. "Quantification of the oxidative damage biomarker 2,3-dinor-8-isoprostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry." Analytical Biochemistry 399, no. 2 (April 2010): 302-304. Full Text
  - Auray-Blais, C, Millington, DS, Barr, C, Young, SP, Mills, K, and Clarke, JTR. "Gb(3)/creatinine biomarkers for Fabry disease: issues to consider." Mol Genet Metab 97, no. 3 (July 2009): 237-. (Letter) Full Text Link to Item
  - Goldstein, JL, Young, SP, Changela, M, Dickerson, GH, Zhang, H, Dai, J, Peterson, D, Millington, DS, Kishnani, PS, and Bali, DS. "Screening for Pompe disease using a rapid dried blood spot method: experience of a clinical diagnostic laboratory." Muscle Nerve 40, no. 1 (July 2009): 32-36. Full Text Link to Item
  - Surwit, RS, Lane, JD, Millington, DS, Zhang, H, Feinglos, MN, Minda, S, Merwin, R, Kuhn, CM, Boston, RC, and Georgiades, A. "Hostility and minimal model of glucose kinetics in African American women." Psychosomatic Medicine 71, no. 6 (July 2009): 646-651. Full Text
  - Young, SP, Zhang, H, Corzo, D, Thurberg, BL, Bali, D, Kishnani, PS, and Millington, DS. "Long-term monitoring of patients with infantile-onset Pompe disease on enzyme replacement therapy using a urinary glucose tetrasaccharide biomarker." Genetics in Medicine : Official Journal of the American College of Medical Genetics 11, no. 7 (July 2009): 536-541. Full Text
  - Newgard, CB, An, J, Bain, JR, Muehlbauer, MJ, Stevens, RD, Lien, LF, Haqq, AM, Shah, SH, Arlotto, M, Slentz, CA, Rochon, J, Gallup, D, Ilkayeva, O, Wenner, BR, Yancy, WS, Eisenson, H, Musante, G, Surwit, R, Millington, DS, Butler, MD, and Svetkey, LP. "A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance." Cell Metabolism 9, no. 6 (June 2009): 565-566. Full Text
  - Auray-Blais, C, Millington, DS, Young, SP, Clarke, JTR, and Schiffmann, R. "Proposed high-risk screening protocol for Fabry disease in patients with renal and vascular disease." J Inherit Metab Dis 32, no. 2 (April 2009): 303-308. (Letter) Full Text Link to Item
  - Newgard, CB, An, J, Bain, JR, Muehlbauer, MJ, Stevens, RD, Lien, LF, Haqq, AM, Shah, SH, Arlotto, M, Slentz, CA, Rochon, J, Gallup, D, Ilkayeva, O, Wenner, BR, Yancy, WS, Eisenson, H, Musante, G, Surwit, RS, Millington, DS, Butler, MD, and Svetkey, LP. "A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance." Cell Metabolism 9, no. 4 (April 2009): 311-326. Full Text
  - Zhang, H, Stevens, RD, Young, SP, Surwit, R, Georgiades, A, Boston, R, and Millington, DS. "A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6]glucose as a tracer." Clinical Chemistry 55, no. 3 (March 2009): 527-532. Full Text
  - Lien, LF, Haqq, AM, Arlotto, M, Slentz, CA, Muehlbauer, MJ, McMahon, RL, Rochon, J, Gallup, D, Bain, JR, Ilkayeva, O, Wenner, BR, Stevens, RD, Millington, DS, Muoio, DM, Butler, MD, Newgard, CB, and Svetkey, LP. "The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain." Omics : a Journal of Integrative Biology 13, no. 1 (February 2009): 21-35. Full Text
  - Millington, DS. "Rapid and effective screening for lysosomal storage disease: how close are we?." Clin Chem 54, no. 10 (October 2008): 1592-1594. Full Text Link to Item
  - Wolfgang, MJ, Cha, SH, Millington, DS, Cline, G, Shulman, GI, Suwa, A, Asaumi, M, Kurama, T, Shimokawa, T, and Lane, MD. "Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight." Journal of Neurochemistry 105, no. 4 (May 2008): 1550-1559. Full Text
  - AURAYBLAIS, C, CYR, D, DROUIN, R, CLARKE, J, and MILLINGTON, D. "Use of urinary globotriaosylceramide for fabry disease screening in Canada." Clinical Therapeutics 30 (2008): S79-S80. Full Text
  - Lee, CR, Geaghan, S, Millington, D, Bennett, M, Von Dadelszen, P, Currier, B, Helmer, G, Lorey, F, Yeo, KT, Hawker, C, Lo, S, Ritchie, J, Sadrzadeh, S, Hammett-Stabler, C, Dufour, DR, and Welch, S. "Guidelines for clinical laboratory practice: Evaluation of maternal-fetal risk and reference values in pregnancy. Section V and VII." Acta Bioquimica Clinica Latinoamericana 41, no. 4 (October 1, 2007): 563-586. (Review)
  - Koeberl, DD, Sun, BD, Damodaran, TV, Brown, T, Millington, DS, Benjamin, DK, Bird, A, Schneider, A, Hillman, S, Jackson, M, Beaty, RM, and Chen, YT. "Erratum: Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia." Gene Therapy 14, no. 3 (February 2007): 281-281. Full Text
  - Koeberl, DD, Sun, BD, Damodaran, TV, Brown, T, Millington, DS, Benjamin, DK, Bird, A, Schneider, A, Hillman, S, Jackson, M, Beaty, RM, and Chen, YT. "Erratum: Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia." Gene Therapy 13, no. 19 (October 2006): 1430-1430. Full Text
  - Koeberl, DD, Sun, BD, Damodaran, TV, Brown, T, Millington, DS, Benjamin, DK, Bird, A, Schneider, A, Hillman, S, Jackson, M, Beaty, RM, and Chen, YT. "Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia." Gene Therapy 13, no. 17 (September 2006): 1281-1289. Full Text
  - Pedersen, CB, Bischoff, C, Christensen, E, Simonsen, H, Lund, AM, Young, SP, Koeberl, DD, Millington, DS, Roe, CR, Roe, DS, Wanders, RJA, Ruiter, JPN, Keppen, LD, Stein, Q, Knudsen, I, Gregersen, N, and Andresen, BS. "Variations in IBD (ACAD8) in children with elevated C4-carnitine detected by tandem mass spectrometry newborn screening." Pediatr Res 60, no. 3 (September 2006): 315-320. Full Text Link to Item
  - "American College of Medical Genetics Newborn Screening Expert Group. Newborn Screening: Toward a Uniform Screening Panel and System--Executive Summary. PEDIATRICS 2006;117:S296-S307." Pediatrics 118, no. 2 (August 1, 2006): 851-851. Full Text
  - "Erratum." Genetics in Medicine 8, no. 6 (June 2006): 382-382. Full Text
  - ACMG Work Group on Management of Pompe Disease, , Kishnani, PS, Steiner, RD, Bali, D, Berger, K, Byrne, BJ, Case, LE, Crowley, JF, Downs, S, Howell, RR, Kravitz, RM, Mackey, J, Marsden, D, Martins, AM, Millington, DS, Nicolino, M, O'Grady, G, Patterson, MC, Rapoport, DM, Slonim, A, Spencer, CT, Tifft, CJ, and Watson, MS. "Pompe disease diagnosis and management guideline." Genetics in Medicine : Official Journal of the American College of Medical Genetics 8, no. 5 (May 2006): 267-288. Full Text
  - Sweetman, L, Millington, DS, Therrell, BL, Hannon, WH, Popovich, B, Watson, MS, Mann, MY, Lloyd-Puryear, MA, and van Dyck, PC. "Naming and counting disorders (conditions) included in newborn screening panels." Pediatrics 117, no. 5 Pt 2 (May 2006): S308-S314. Full Text
  - Zhang, H, Kallwass, H, Young, SP, Carr, C, Dai, J, Kishnani, PS, Millington, DS, Keutzer, J, Chen, Y-T, and Bali, D. "Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease." Genetics in Medicine : Official Journal of the American College of Medical Genetics 8, no. 5 (May 2006): 302-306.
  - Frazier, DM, Millington, DS, McCandless, SE, Koeberl, DD, Weavil, SD, Chaing, SH, and Muenzer, J. "The tandem mass spectrometry newborn screening experience in North Carolina: 1997-2005." J Inherit Metab Dis 29, no. 1 (February 2006): 76-85. Full Text Link to Item
  - Kao, H-J, Cheng, C-F, Chen, Y-H, Hung, S-L, Huang, C-C, Millington, D, Kikuchi, T, Wu, J-Y, and Chen, Y-T. "ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein β-subunit." Human Molecular Genetics 15, no. 24 (2006): 3569-3577. Full Text
  - Haqq, AM, Lien, LF, Boan, J, Arlotto, M, Slentz, CA, Muehlbauer, MJ, Rochon, J, Gallup, D, McMahon, RL, Bain, JR, Stevens, R, Millington, D, Butler, MD, Newgard, CB, and Svetkey, LP. "The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design." Contemporary Clinical Trials 26, no. 6 (December 2005): 616-625. Full Text
  - An, Y, Young, SP, Kishnani, PS, Millington, DS, Amalfitano, A, Corz, D, and Chen, Y-T. "Glucose tetrasaccharide as a biomarker for monitoring the therapeutic response to enzyme replacement therapy for Pompe disease." Mol Genet Metab 85, no. 4 (August 2005): 247-254. Full Text Link to Item
  - Millington, DS. "Newborn screening for lysosomal storage disorders." Clin Chem 51, no. 5 (May 2005): 808-809. Full Text Link to Item
  - An, J, Muoio, DM, Shiota, M, Fujimoto, Y, Cline, GW, Shulman, GI, Koves, TR, Stevens, R, Millington, D, and Newgard, CB. "Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance." Nature Medicine 10, no. 3 (March 2004): 268-274. Full Text
  - Wu, J-Y, Kao, H-J, Li, S-C, Stevens, R, Hillman, S, Millington, D, and Chen, Y-T. "ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease." The Journal of Clinical Investigation 113, no. 3 (February 2004): 434-440. Full Text
  - Young, SP, Matern, D, Gregersen, N, Stevens, RD, Bali, D, Liu, H-M, Koeberl, DD, and Millington, DS. "A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency." Clinica Chimica Acta; International Journal of Clinical Chemistry 337, no. 1-2 (November 2003): 103-113. Full Text
  - Koeberl, DD, Young, SP, Gregersen, NS, Vockley, J, Smith, WE, Benjamin, DK, An, Y, Weavil, SD, Chaing, SH, Bali, D, McDonald, MT, Kishnani, PS, Chen, Y-T, and Millington, DS. "Rare disorders of metabolism with elevated butyryl- and isobutyryl-carnitine detected by tandem mass spectrometry newborn screening." Pediatric Research 54, no. 2 (August 2003): 219-223. Full Text
  - Young, SP, Stevens, RD, An, Y, Chen, Y-T, and Millington, DS. "Analysis of a glucose tetrasaccharide elevated in Pompe disease by stable isotope dilution-electrospray ionization tandem mass spectrometry." Anal Biochem 316, no. 2 (May 15, 2003): 175-180. Link to Item
  - Koeberl, DD, Millington, DS, Smith, WE, Weavil, SD, Muenzer, J, McCandless, SE, Kishnani, PS, McDonald, MT, Chaing, S, Boney, A, Moore, E, and Frazier, DM. "Evaluation of 3-methylcrotonyl-CoA carboxylase deficiency detected by tandem mass spectrometry newborn screening." Journal of Inherited Metabolic Disease 26, no. 1 (January 2003): 25-35. Full Text
  - "Isomeric oligosaccharide analysis using hydrophilic interaction LC-ESI-MS/MS." Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics (December 1, 2002): 413-414.
  - "An LC-MS/MS method for determination of glycosaminoglycan content of urine for the diagnosis of mucopolysaccharidoses." Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics (December 1, 2002): 597-598.
  - Kohn, MC, Tohmaz, AS, Giroux, KJ, Blumenthal, GM, Feezor, MD, and Millington, DS. "Robustness of MetaNet graph models: predicting control of urea production in humans." Biosystems 65, no. 1 (February 2002): 61-78. Link to Item
  - Millington, D. "Newborn Screening for Metabolic Diseases." American Scientist 90, no. 1 (2002): 40-40. Full Text
  - Simpson, DM, Katzenstein, D, Haidich, B, Millington, D, Yiannoutsos, C, Schifitto, G, McArthur, J, and AIDS Clinical Trials Group Protocol 291/860 Study Team, . "Plasma carnitine in HIV-associated neuropathy." Aids (London, England) 15, no. 16 (November 2001): 2207-2208. (Letter) Full Text
  - Cox, KB, Hamm, DA, Millington, DS, Matern, D, Vockley, J, Rinaldo, P, Pinkert, CA, Rhead, WJ, Lindsey, JR, and Wood, PA. "Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse." Human Molecular Genetics 10, no. 19 (September 2001): 2069-2077. Full Text
  - Smith, WE, Millington, DS, Koeberl, DD, and Lesser, PS. "Glutaric acidemia, type I, missed by newborn screening in an infant with dystonia following promethazine administration." Pediatrics 107, no. 5 (May 2001): 1184-1187. Full Text
  - Matern, D, Hart, P, Murtha, AP, Vockley, J, Gregersen, N, Millington, DS, and Treem, WR. "Acute fatty liver of pregnancy associated with short-chain acyl-coenzyme A dehydrogenase deficiency." J Pediatr 138, no. 4 (April 2001): 585-588. Full Text Link to Item
  - An, Y, Young, SP, Hillman, SL, Van Hove, JL, Chen, YT, and Millington, DS. "Liquid chromatographic assay for a glucose tetrasaccharide, a putative biomarker for the diagnosis of Pompe disease." Anal Biochem 287, no. 1 (December 1, 2000): 136-143. Full Text Link to Item
  - Center, SA, Harte, J, Watrous, D, Reynolds, A, Watson, TD, Markwell, PJ, Millington, DS, Wood, PA, Yeager, AE, and Erb, HN. "The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine." Journal of Veterinary Internal Medicine 14, no. 6 (November 2000): 598-608. Full Text
  - Van Hove, JL, Kahler, SG, Feezor, MD, Ramakrishna, JP, Hart, P, Treem, WR, Shen, JJ, Matern, D, and Millington, DS. "Acylcarnitines in plasma and blood spots of patients with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase defiency." J Inherit Metab Dis 23, no. 6 (September 2000): 571-582. Link to Item
  - Stevens, RD, Hillman, SL, Worthy, S, Sanders, D, and Millington, DS. "Assay for free and total carnitine in human plasma using tandem mass spectrometry." Clin Chem 46, no. 5 (May 2000): 727-729. Link to Item
  - Shen, JJ, Matern, D, Millington, DS, Hillman, S, Feezor, MD, Bennett, MJ, Qumsiyeh, M, Kahler, SG, Chen, YT, and Van Hove, JL. "Acylcarnitines in fibroblasts of patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and other fatty acid oxidation disorders." J Inherit Metab Dis 23, no. 1 (February 2000): 27-44. Link to Item
  - Gibson, KM, Burlingame, TG, Hogema, B, Jakobs, C, Schutgens, RBH, Millington, D, Roe, CR, Roe, DS, Sweetman, L, Steiner, RD, Linck, L, Pohowalla, P, Sacks, M, Kiss, D, Rinaldo, P, and Vockley, J. "2-Methylbutyryl-coenzyme a dehydrogenase deficiency: A new inborn error of L-isoleucine metabolism." Pediatric Research 47, no. 6 (2000): 830-833.
  - Ahmad, A, Kahler, SG, Kishnani, PS, Artigas-Lopez, M, Pappu, AS, Steiner, R, Millington, DS, and Van Hove, JL. "Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate." American Journal of Medical Genetics 87, no. 4 (December 1999): 331-338. Full Text
  - "Untypical case of multiple acyl-CoA-dehydrogenase deficiency." Klinische Padiatrie 211, no. 5 (November 4, 1999): 413-416.
  - Lee, C, Tsai, FJ, Wu, JY, Peng, CT, Tsai, CH, Hwu, WL, Wang, TR, and Millington, DS. "3-hydroxy-3-methylglutaric aciduria presenting with Reye like syndrome: report of one case." Acta Paediatr Taiwan 40, no. 6 (November 1999): 445-447. Link to Item
  - Rose, M, Matern, D, Millington, DS, and Lehnert, W. "[Atypical course of a multiple acyl-CoA-dehydrogenase deficiency]." Klin Padiatr 211, no. 5 (September 1999): 413-416. Full Text Link to Item
  - Matern, D, Strauss, AW, Hillman, SL, Mayatepek, E, Millington, DS, and Trefz, FK. "Diagnosis of mitochondrial trifunctional protein deficiency in a blood spot from the newborn screening card by tandem mass spectrometry and DNA analysis." Pediatr Res 46, no. 1 (July 1999): 45-49. Link to Item
  - Rose, M, Matern, D, Millington, DS, and Lehnert, W. "Untypical case of multiple acyl-CoA-dehydrogenase deficiency." Klinische Padiatrie 211, no. 5 (1999): 413-416.
  - Kurtz, DM, Rinaldo, P, Rhead, WJ, Tian, L, Millington, DS, Vockley, J, Hamm, DA, Brix, AE, Lindsey, JR, Pinkert, CA, O'Brien, WE, and Wood, PA. "Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation." Proceedings of the National Academy of Sciences of the United States of America 95, no. 26 (December 1998): 15592-15597. Full Text
  - Russell, BG, Moddeman, WE, Birkbeck, JC, Wright, SE, Millington, DS, Stevens, RD, and Dombrowski, KE. "Surface structure of human mucin using X-ray photoelectron spectroscopy." Biospectroscopy 4, no. 4 (1998): 257-266. Full Text
  - Russell, BG, Moddeman, WE, Birkbeck, JC, Wright, SE, Millington, DS, Stevens, RD, and Dombrowski, KE. "Surface structure of human mucin using X-ray photoelectron spectroscopy." Biospectroscopy 4, no. 4 (January 1998): 257-266. Full Text
  - Triggs, WJ, Gilmore, RL, Millington, DS, Cibula, J, Bunch, TS, and Harman, E. "Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure." Int J Clin Pharmacol Ther 35, no. 9 (September 1997): 353-356. Link to Item
  - "Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung." American Journal of Physiology Lung Cellular and Molecular Physiology 272, no. 6 16-6 (June 1, 1997).
  - Kantrow, SP, Huang, YC, Whorton, AR, Grayck, EN, Knight, JM, Millington, DS, and Piantadosi, CA. "Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung." The American Journal of Physiology 272, no. 6 Pt 1 (June 1997): L1167-L1173. Full Text
  - Treem, WR, Shoup, ME, Hale, DE, Bennett, MJ, Rinaldo, P, Millington, DS, Stanley, CA, Riely, CA, and Hyams, JS. "Acute fatty liver of pregnancy, hemolysis, elevated liver enzymes, and low platelets syndrome, and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency." The American Journal of Gastroenterology 91, no. 11 (November 1996): 2293-2300.
  - Stevens, MJ, Lattimer, SA, Feldman, EL, Helton, ED, Millington, DS, Sima, AA, and Greene, DA. "Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat." Metabolism 45, no. 7 (July 1996): 865-872. Link to Item
  - Chace, DH, Hillman, SL, Millington, DS, Kahler, SG, Adam, BW, and Levy, HL. "Rapid diagnosis of homocystinuria and other hypermethioninemias from newborns' blood spots by tandem mass spectrometry." Clin Chem 42, no. 3 (March 1996): 349-355. Link to Item
  - Feoli-Fonseca, JC, Lambert, M, Mitchell, G, Melançon, SB, Dallaire, L, Millington, DS, and Qureshi, IA. "Chronic sodium benzoate therapy in children with inborn errors of urea synthesis: effect on carnitine metabolism and ammonia nitrogen removal." Biochem Mol Med 57, no. 1 (February 1996): 31-36. Link to Item
  - Brivet, M, Slama, A, Millington, DS, Roe, CR, Demaugre, F, Legrand, A, Boutron, A, Poggi, F, and Saudubray, JM. "Retrospective diagnosis of carnitine-acylcarnitine translocase deficiency by acylcarnitine analysis in the proband Guthrie card and enzymatic studies in the parents." J Inherit Metab Dis 19, no. 2 (1996): 181-184. Link to Item
  - Van Hove, JL, Kishnani, P, Muenzer, J, Wenstrup, RJ, Summar, ML, Brummond, MR, Lachiewicz, AM, Millington, DS, and Kahler, SG. "Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia." Am J Med Genet 59, no. 4 (December 4, 1995): 444-453. Full Text Link to Item
  - Röschinger, W, Millington, DS, Gage, DA, Huang, ZH, Iwamoto, T, Yano, S, Packman, S, Johnston, K, Berry, SA, and Sweetman, L. "3-Hydroxyisovalerylcarnitine in patients with deficiency of 3-methylcrotonyl CoA carboxylase." Clin Chim Acta 240, no. 1 (August 31, 1995): 35-51. Link to Item
  - Chace, DH, Hillman, SL, Millington, DS, Kahler, SG, Roe, CR, and Naylor, EW. "Rapid diagnosis of maple syrup urine disease in blood spots from newborns by tandem mass spectrometry." Clin Chem 41, no. 1 (January 1995): 62-68. Link to Item
  - Rutledge, SL, Berry, GT, Stanley, CA, Hove, JLKV, and Millington, D. "Glycine and l-carnitine therapy in 3-methylcrotonyl-CoA carboxylase deficiency." Journal of Inherited Metabolic Disease 18, no. 3 (1995): 299-305. Full Text
  - Tein, I, Sloane, AE, Donner, EJ, Lehotay, DC, Millington, DS, and Kelley, RI. "Fatty acid oxidation abnormalities in childhood-onset spinal muscular atrophy: primary or secondary defect(s)?." Pediatr Neurol 12, no. 1 (January 1995): 21-30. Link to Item
  - van Hove, JL, Rutledge, SL, Nada, MA, Kahler, SG, and Millington, DS. "3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency." J Inherit Metab Dis 18, no. 5 (1995): 592-601. Link to Item
  - Matchar, DB, McCrory, DC, Millington, DS, and Feussner, JR. "Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency." Am J Med Sci 308, no. 5 (November 1994): 276-283. Link to Item
  - Ozand, PT, Rashed, M, Millington, DS, Sakati, N, Hazzaa, S, Rahbeeni, Z, al Odaib, A, Youssef, N, Mazrou, A, and Gascon, GG. "Ethylmalonic aciduria: an organic acidemia with CNS involvement and vasculopathy." Brain Dev 16 Suppl (November 1994): 12-22. Link to Item
  - Bonaventura, C, Bonaventura, J, Stevens, R, and Millington, D. "Acrylamide in polyacrylamide gels can modify proteins during electrophoresis." Anal Biochem 222, no. 1 (October 1994): 44-48. Full Text Link to Item
  - Stevens, RD, Bonaventura, J, Bonaventura, C, Fennel, TR, and Millington, DS. "Application of electrospray ionization mass spectrometry for analysis of haemoglobin adducts with acrylonitrile." Biochem Soc Trans 22, no. 2 (May 1994): 543-547. Link to Item
  - Treem, WR, Rinaldo, P, Hale, DE, Stanley, CA, Millington, DS, Hyams, JS, Jackson, S, and Turnbull, DM. "Acute fatty liver of pregnancy and long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency." Hepatology (Baltimore, Md.) 19, no. 2 (February 1994): 339-345. Full Text
  - Van Hove, JL, Kahler, SG, Millington, DS, Roe, DS, Chace, DH, Heales, SJ, and Roe, CR. "Intravenous L-carnitine and acetyl-L-carnitine in medium-chain acyl-coenzyme A dehydrogenase deficiency and isovaleric acidemia." Pediatric Research 35, no. 1 (January 1994): 96-101. Full Text
  - Van Hove, JL, Zhang, W, Kahler, SG, Roe, CR, Chen, YT, Terada, N, Chace, DH, Iafolla, AK, Ding, JH, and Millington, DS. "Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood." American Journal of Human Genetics 52, no. 5 (May 1993): 958-966.
  - "Dietary supplement L-carnitine: Analysis of different brands to determine bioavailability and content." Clinical Research and Regulatory Affairs 10, no. 2 (January 1, 1993): 71-80.
  - Chace, DH, Millington, DS, Terada, N, Kahler, SG, Roe, CR, and Hofman, LF. "Rapid diagnosis of phenylketonuria by quantitative analysis for phenylalanine and tyrosine in neonatal blood spots by tandem mass spectrometry." Clinical Chemistry 39, no. 1 (January 1993): 66-71.
  - Van Hove, JL, Chace, DH, Kahler, SG, and Millington, DS. "Acylcarnitines in amniotic fluid: application to the prenatal diagnosis of propionic acidaemia." J Inherit Metab Dis 16, no. 2 (1993): 361-367. Link to Item
  - Doerge, DR, Bajic, S, and Millington, DS. "Analysis of pesticides using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry." Rapid Communications in Mass Spectrometry 6, no. 11 (November 1992): 663-666. Full Text
  - Roe, DS, Terada, N, and Millington, DS. "Automated analysis for free and short-chain acylcarnitine in plasma with a centrifugal analyzer." Clin Chem 38, no. 11 (November 1992): 2215-2220. Link to Item
  - Campistol, J, Ribes, A, Alvarez, L, Christensen, E, and Millington, DS. "Glutaric aciduria type I: unusual biochemical presentation." J Pediatr 121, no. 1 (July 1992): 83-86. Link to Item
  - Portilla, D, Mandel, LJ, Bar-Sagi, D, and Millington, DS. "Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules." The American Journal of Physiology 262, no. 3 Pt 2 (March 1992): F354-F360. Full Text
  - Mao, LF, Millington, DS, and Schulz, H. "Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid." The Journal of Biological Chemistry 267, no. 5 (February 1992): 3143-3146.
  - Berman, J, Green, M, Sugg, E, Anderegg, R, Millington, DS, Norwood, DL, McGeehan, J, and Wiseman, J. "Rapid optimization of enzyme substrates using defined substrate mixtures." J Biol Chem 267, no. 3 (January 25, 1992): 1434-1437. Link to Item
  - Bennett, MJ, Rinaldo, P, Yokota, I, Millington, DS, and Coates, PM. "Letter to the Editor." Pediatric Pathology 12, no. 4 (January 1992): 621-625. Full Text
  - Ding, JH, Bross, P, Yang, BZ, Iafolla, AK, Millington, DS, Roe, CR, Gregersen, N, and Chen, YT. "Genetic heterogeneity in MCAD deficiency: frequency of K329E allele and identification of three additional mutant alleles." Prog Clin Biol Res 375 (1992): 479-488. Link to Item
  - Millington, DS, Terada, N, Chace, DH, Chen, YT, Ding, JH, Kodo, N, and Roe, CR. "The role of tandem mass spectrometry in the diagnosis of fatty acid oxidation disorders." Prog Clin Biol Res 375 (1992): 339-354. Link to Item
  - Ribes, A, Riudor, E, Briones, P, Christensen, E, Campistol, J, and Millington, DS. "Significance of bound glutarate in the diagnosis of glutaric aciduria type I." Journal of Inherited Metabolic Disease 15, no. 3 (January 1992): 367-370. Full Text
  - Millington, DS, Kodo, N, Terada, N, Roe, D, and Chace, DH. "The analysis of diagnostic markers of genetic disorders in human blood and urine using tandem mass spectrometry with liquid secondary ion mass spectrometry." International Journal of Mass Spectrometry and Ion Processes 111 (December 1991): 211-228. Full Text
  - Bennett, MJ, Rinaldo, P, Millington, DS, Tanaka, K, Yokota, I, and Coates, PM. "Medium-chain acyl-CoA dehydrogenase deficiency: postmortem diagnosis in a case of sudden infant death and neonatal diagnosis of an affected sibling." Pediatric Pathology 11, no. 6 (November 1991): 889-895. Full Text
  - Millington, DS, Norwood, DL, Kodo, N, Moore, R, Green, MD, and Berman, J. "Biomedical applications of high-performance liquid chromatography-mass spectrometry with continuous-flow fast atom bombardment." Journal of Chromatography 562, no. 1-2 (January 1991): 47-58.
  - Howell, JA, and Hargis, LG. "Ultraviolet and light absorption spectrometry." Analytical Chemistry 62, no. 12 (June 15, 1990): 155-169. Full Text
  - Burlingame, AL, Millington, DS, Norwood, DL, and Russell, DH. "Mass spectrometry." Analytical Chemistry 62, no. 12 (June 1990): 268R-303R. (Review) Full Text
  - Norwood, DL, Bus, CA, and Millington, DS. "Combined high-performance liquid chromatographic-continuous-flow fast atom bombardment mass spectrometric analysis of acylcoenzyme A compounds." J Chromatogr 527, no. 2 (May 18, 1990): 289-301. Link to Item
  - Roe, CR, Millington, DS, Norwood, DL, Kodo, N, Sprecher, H, Mohammed, BS, Nada, M, Schulz, H, and McVie, R. "2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation." The Journal of Clinical Investigation 85, no. 5 (May 1990): 1703-1707. Full Text
  - Kodo, N, Millington, DS, Norwood, DL, and Roe, CR. "Quantitative assay of free and total carnitine using tandem mass spectrometry." Clin Chim Acta 186, no. 3 (January 31, 1990): 383-390. Link to Item
  - Bennett, MJ, Coates, PM, Hale, DE, Millington, DS, Pollitt, RJ, Rinaldo, P, Roe, CR, and Tanaka, K. "Analysis of abnormal urinary metabolites in the newborn period in medium-chain acyl-CoA dehydrogenase deficiency." J Inherit Metab Dis 13, no. 5 (1990): 707-715. Link to Item
  - Millington, DS, Kodo, N, Norwood, DL, and Roe, CR. "Tandem mass spectrometry: a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism." Journal of Inherited Metabolic Disease 13, no. 3 (January 1990): 321-324. Full Text
  - Moore, R, Millington, DS, Norwood, D, Kodo, N, Robinson, P, and Glasgow, JF. "Identification of phenylpropionylcarnitine, a new metabolite of phenylpropionic acid, in a patient with medium chain acyl-CoA dehydrogenase deficiency." J Inherit Metab Dis 13, no. 3 (1990): 325-329. Link to Item
  - Roe, CR, Millington, DS, Kahler, SG, Kodo, N, and Norwood, DL. "Carnitine homeostasis in the organic acidurias." Progress in Clinical and Biological Research 321 (January 1990): 383-402. (Review)
  - Wood, PA, Amendt, BA, Rhead, WJ, Armstrong, D, Millington, DS, and Inoue, F. "A murine model for short-chain acyl-CoA dehydrogenase deficiency." Prog Clin Biol Res 321 (1990): 427-434. Link to Item
  - Chen, LS, Millington, DS, Maltby, DA, and McNamara, JO. "Effects of intranigral application of clinically-effective anticonvulsants on electroshock-induced seizures." Neuropharmacology 28, no. 8 (August 1989): 781-786. Full Text
  - Kahler, SG, Millington, DS, Cederbaum, SD, Vargas, J, Bond, LD, Maltby, DA, Gale, DS, and Roe, CR. "Parenteral nutrition in propionic and methylmalonic acidemia." J Pediatr 115, no. 2 (August 1989): 235-241. Link to Item
  - Millington, DS, Norwood, DL, Kodo, N, Roe, CR, and Inoue, F. "Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography/mass spectrometry to the analysis of acylcarnitines in human urine, blood, and tissue." Analytical Biochemistry 180, no. 2 (August 1989): 331-339. Full Text
  - Sansbury, K, Millington, DS, and Coleman, RA. "Hepatic monoacylglycerol acyltransferase: ontogeny and characterization of an activity associated with the chick embryo." J Lipid Res 30, no. 8 (August 1989): 1251-1258. Link to Item
  - Millington, DS, and Roe, CR. "Medium-chain acyl-CoA dehydrogenase deficiency." N Engl J Med 320, no. 18 (May 4, 1989): 1219-. (Letter) Full Text Link to Item
  - Wood, PA, Amendt, BA, Rhead, WJ, Millington, DS, Inoue, F, and Armstrong, D. "Short-chain acyl-coenzyme A dehydrogenase deficiency in mice." Pediatric Research 25, no. 1 (January 1989): 38-43. Full Text
  - Norwood, DL, Kodo, N, and Millington, DS. "Application of continuous-flow liquid chromatography/fast-atom bombardment mass spectrometry to the analysis of diagnostic acylcarnitines in human urine." Rapid Commun Mass Spectrom 2, no. 12 (December 1988): 269-272. Full Text Link to Item
  - Pramanik, BC, Hinton, SM, Millington, DS, Dourdeville, TA, and Slaughter, CA. "Analysis of phenylthiohydantoin amino acid mixtures for sequencing by thermospray liquid chromatography/mass spectrometry." Anal Biochem 175, no. 1 (November 15, 1988): 305-318. Link to Item
  - Pinkston, JD, Owens, GD, Burkes, LJ, Delaney, TE, Millington, DS, and Maltby, DA. "Capillary supercritical fluid chromatography-mass spectrometry using a "high mass" quadrupole and splitless injection." Analytical Chemistry 60, no. 10 (May 15, 1988): 962-966. Full Text
  - Dietrich, AM, Millington, DS, and Seo, Y-H. "Specific identification of synthetic organic chemicals in river water using liquid—liquid extraction and resin adsorption coupled with electron impact, chemical ionization and accurate mass measurement gas chromatography—mass spectrometry analyses." Journal of Chromatography A 436 (January 1988): 229-241. Full Text
  - Kramer, SP, Johnson, JL, Ribeiro, AA, Millington, DS, and Rajagopalan, KV. "The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase." The Journal of Biological Chemistry 262, no. 34 (December 1987): 16357-16363.
  - Millington, DS, Roe, CR, and Maltby, DA. "Characterization of new diagnostic acylcarnitines in patients with beta-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry." Biomed Environ Mass Spectrom 14, no. 12 (December 1987): 711-716. Full Text Link to Item
  - Matchar, DB, Feussner, JR, Millington, DS, Wilkinson, RH, Watson, DJ, and Gale, D. "Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation." Ann Intern Med 106, no. 5 (May 1987): 707-710. Link to Item
  - Roe, CR, Millington, DS, Maltby, DA, and Wellman, RB. "Post-mortem recognition of inherited metabolic disorders from specific acylcarnitines in tissue in cases of sudden infant death." Lancet 1, no. 8531 (February 28, 1987): 512-. (Letter) Link to Item
  - Frimmel, FH, Millington, DS, and Christman, RF. "Quantitative determination of organic compounds in extracts of activated carbon by means of GC/MS." Fresenius' Zeitschrift für Analytische Chemie 327, no. 2 (1987): 149-153. Full Text
  - Frimmel, FH, Millington, DS, and Christman, RF. "Quantifizierung organischer Substanzen in Aktivkohleextrakten mit Hilfe der Gas-Chromatographie/Massenspektrometrie." Fresenius' Zeitschrift F�R Analytische Chemie 327, no. 2 (1987): 149-153. Full Text
  - Millington, DS, Roe, CR, Maltby, DA, and Inoue, F. "Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia." J Pediatr 110, no. 1 (January 1987): 56-60. Link to Item
  - Gaskell, SJ, Guenat, C, Millington, DS, Maltby, DA, and Roe, CR. "Differentiation of isomeric acylcarnitines using tandem mass spectrometry." Anal Chem 58, no. 13 (November 1986): 2801-2805. Link to Item
  - Dietrich, AM, Gallagher, DL, Derosa, PM, Millington, DS, and Digiano, FA. "Enhancement of N-nitrosamine formation on granular-activated carbon from N-methylaniline and nitrite." Environ Sci Technol 20, no. 10 (October 1, 1986): 1050-1055. Full Text Link to Item
  - Roe, CR, Millington, DS, and Maltby, DA. "Identification of 3-methylglutarylcarnitine. A new diagnostic metabolite of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency." J Clin Invest 77, no. 4 (April 1986): 1391-1394. Full Text Link to Item
  - Maltby, DA, and Millington, DS. "Analysis of volatile free fatty acids in human urine by capillary column gas chromatography/mass spectrometry." Clin Chim Acta 155, no. 2 (March 16, 1986): 167-172. Link to Item
  - Millington, DS, Maltby, DA, and Roe, CR. "Rapid detection of argininosuccinic aciduria and citrullinuria by fast atom bombardment and tandem mass spectrometry." Clin Chim Acta 155, no. 2 (March 16, 1986): 173-178. Link to Item
  - Szakal-Quin, G, Graham, DG, Millington, DS, Maltby, DA, and McPhail, AT. "Stereoisomer effects on the Paal-Knorr synthesis of pyrroles." The Journal of Organic Chemistry 51, no. 5 (March 1986): 621-624. Full Text
  - Coleman, RA, Walsh, JP, Millington, DS, and Maltby, DA. "Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver." Journal of Lipid Research 27, no. 2 (February 1986): 158-165.
  - Roe, CR, Millington, DS, Maltby, DA, and Kinnebrew, P. "Recognition of medium-chain acyl-CoA dehydrogenase deficiency in asymptomatic siblings of children dying of sudden infant death or Reye-like syndromes." J Pediatr 108, no. 1 (January 1986): 13-18. Link to Item
  - "QUANTITATIVE ANALYSIS OF FORMALDEHYDE CONDENSATES IN THE VAPOR STATE." Advances in Chemistry Series (December 1, 1985): 57-65.
  - Gray, TK, Millington, DS, Maltby, DA, Williams, ME, Cohen, MS, and Dodd, RC. "Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a metabolite that may induce differentiation of the human monoblastic cell line U937." Proceedings of the National Academy of Sciences of the United States of America 82, no. 23 (December 1985): 8218-8221. Full Text
  - Roe, CR, Millington, DS, Maltby, DA, Bohan, TP, Kahler, SG, and Chalmers, RA. "Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency." Pediatr Res 19, no. 5 (May 1985): 459-466. Link to Item
  - Millington, DS, Bohan, TP, Roe, CR, Yergey, AL, and Liberato, DJ. "Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry." Clin Chim Acta 145, no. 1 (January 15, 1985): 69-76. Link to Item
  - Millington, DS, Bohan, TP, Roe, CR, Yergey, AL, and Liberato, DJ. "Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry." Clinica Chimica Acta 145, no. 1 (January 1985): 69-76. Full Text
  - "QUALITATIVE AND QUANTITATIVE ANALYSIS OF SYNTHETIC ORGANIC POLLUTANTS IN RIVER WATER BY GC/MS." Annual Conference on Mass Spectrometry and Allied Topics (December 1, 1984): 259-260.
  - "IDENTIFICATION AND QUANTITATIVE ANALYSIS OF ACYLCARNITINES IN HUMAN URINE BY THERMOSPRAY HPLC/MS." Annual Conference on Mass Spectrometry and Allied Topics (December 1, 1984): 76-77.
  - "GC/MS ANALYSIS OF FREE SHORT CHAIN CARBOXYLIC ACIDS BY ON-COLUMN INJECTION ON A FUSED SILICA CAPILLARY COLUMN." Annual Conference on Mass Spectrometry and Allied Topics (December 1, 1984): 583-584.
  - "CHARACTERIZATION OF COENZYME A AND ITS ACYL DERIVATIVES BY FAB-MS/MS." Annual Conference on Mass Spectrometry and Allied Topics (December 1, 1984): 398-399.
  - Gold, A, Utterback, DF, and Millington, DS. "Quantitative analysis of gas-phase formaldehyde molecular species at equilibrium with formalin solution." Anal Chem 56, no. 14 (December 1984): 2879-2882. Link to Item
  - Roe, CR, Millington, DS, Maltby, DA, Kahler, SG, and Bohan, TP. "L-carnitine therapy in isovaleric acidemia." J Clin Invest 74, no. 6 (December 1984): 2290-2295. Full Text Link to Item
  - Roe, CR, Millington, DS, Maltby, DA, Bohan, TP, and Hoppel, CL. "L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia." The Journal of Clinical Investigation 73, no. 6 (June 1984): 1785-1788. Full Text
  - Yergey, AL, Liberato, DJ, and Millington, DS. "Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives." Analytical Biochemistry 139, no. 2 (June 1984): 278-283. Full Text
  - Millington, DS, Roe, CR, and Maltby, DA. "Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease." Biomed Mass Spectrom 11, no. 5 (May 1984): 236-241. Full Text Link to Item
  - Utterback, DF, Millington, DS, and Gold, A. "Characterization and determination of formaldehyde oligomers by capillary column gas chromatography." Analytical Chemistry 56, no. 3 (March 1984): 470-473. Full Text
  - "FORMALDEHYDE CONDENSATION PRODUCTS IN THE GAS PHASE." National Meeting American Chemical Society, Division of Environmental Chemistry 24, no. 1 (January 1, 1984): 78-81.
  - Chalmers, RA, Stacey, TE, Tracey, BM, de Sousa, C, Roe, CR, Millington, DS, and Hoppel, CL. "L-Carnitine insufficiency in disorders of organic acid metabolism: response to L-carnitine by patients with methylmalonic aciduria and 3-hydroxy-3-methylglutaric aciduria." J Inherit Metab Dis 7 Suppl 2 (1984): 109-110. Link to Item
  - "ANALYSIS OF ORGANIC COMPOUNDS ADSORBED ON GRANULAR ACTIVATED CARBON FILTERS USED IN TREATMENT PLANTS." Water Chlorination: Environmental Impact and Health Effects 4, no. nook 1 (December 1, 1983): 445-454.
  - "CHARACTERIZATION OF FORMALDEHYDE OLIGOMERS BY CAPILLARY GC/AMMONIA CI." Annual Conference on Mass Spectrometry and Allied Topics (December 1, 1983): 229-230.
  - "ORGANIC REACTION PRODUCTS OF CHLORINE DIOXIDE AND NATURAL AQUATIC FULVIC ACIDS." Water Chlorination: Environmental Impact and Health Effects 4, no. nook 1 (December 1, 1983): 219-229.
  - "CHLORINATION PRODUCTS FROM AQUATIC HUMIC MATERIAL AT NEUTRAL pH." Water Chlorination: Environmental Impact and Health Effects 4, no. nook 1 (December 1, 1983): 191-200.
  - "CHARACTERIZATION AND ANALYSIS OF ACYLCARNITINES BY FAB AND B/E LINKED SCANNING: APPLICATION TO METABOLIC DISEASE." Annual Conference on Mass Spectrometry and Allied Topics (December 1, 1983): 361-362.
  - DiGiano, FA. "ENHANCEMENT OF N-NITROSAMINE FORMATION ON GRANULAR ACTIVATED CARBON FROM N-METHYL ANILINE." National Meeting American Chemical Society, Division of Environmental Chemistry 23, no. 2 (December 1, 1983): 382-383.
  - Johnson, JD. "BY-PRODUCTS OF CHLORINATION: SPECIFIC COMPOUNDS AND THEIR RELATIONSHIP TO TOTAL ORGANIC HALOGEN." National Meeting American Chemical Society, Division of Environmental Chemistry 23, no. 2 (December 1, 1983): 65-68.
  - Roe, CR, Hoppel, CL, Stacey, TE, Chalmers, RA, Tracey, BM, and Millington, DS. "Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups." Arch Dis Child 58, no. 11 (November 1983): 916-920. Link to Item
  - Christman, RF, Norwood, DL, Millington, DS, Johnson, JD, and Stevens, AA. "Identity and yields of major halogenated products of aquatic fulvic acid chlorination." Environ Sci Technol 17, no. 10 (October 1, 1983): 625-628. Full Text Link to Item
  - Dietrich, AM, Millington, DS, and Christman, RF. "SPECIFIC IDENTIFICATION OF ORGANIC POLLUTANTS IN HAW RIVER WATER USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY." Report - Water Resources Research Institute of The University of North Carolina , no. 206 (January 1, 1983).
  - Dietrich, AM, Millington, DS, and Christman, RF. "SPECIFIC IDENTIFICATION OF ORGANIC POLLUTANTS IN HAW RIVER WATER USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY." Report - Water Resources Research Institute of The University of North Carolina , no. 206 (1983): var-paging.
  - Millington, DS, Kamei, T, Bertino, D, and Maltby, D. "ANALYSIS OF ORGANIC MATERIAL ACCUMULATED ON GRANULAR ACTIVATED CARBON FILTERS USED IN DRINKING WATER TREATMENT." Annual Conference on Mass Spectrometry and Allied Topics (1983): 460--.
  - Johnson, JD, Christman, RF, Norwood, DL, and Millington, DS. "Reaction products of aquatic humic substances with chlorine." Environ Health Perspect 46 (December 1982): 63-71. Link to Item
  - Liao, W, Christman, RF, Johnson, JD, Millington, DS, and Hass, JR. "Structural characterization of aquatic humic material." Environ Sci Technol 16, no. 7 (July 1, 1982): 403-410. Full Text Link to Item
  - Pandey, RC, Rinehart, KL, and Millington, DS. "The structures of dermostatins A and B 1,2." Hindustan Antibiot Bull 22, no. 3-4 (February 1980): 47-61. Link to Item
  - Gaskell, SJ, Pike, AW, and Millington, DS. "The fragmentation of stereoisomeric androstanediolt-butyldimethylsilyl ethers. A study by linked field scanning." Biological Mass Spectrometry 6, no. 2 (February 1979): 78-81. Full Text
  - Gaskell, SJ, and Millington, DS. "Selected metastable peak monitoring: a new specific technique in quantitative gas chromatography mass spectrometry." Biomed Mass Spectrom 5, no. 9 (September 1978): 557-558. Full Text Link to Item
  - Millington, DS. "New techniques in quantitative mass spectrometry." J Reprod Fertil 51, no. 1 (September 1977): 303-308. Link to Item
  - Liesch, JM, Millington, DS, Pandey, RC, and Rinehart, KL. "Berninamycin. 2. Products of acidic hydrolysis, methanolysis, and acetolysis of berninamycin A1." J Am Chem Soc 98, no. 25 (December 8, 1976): 8237-8249. Link to Item
  - Millington, DS, Golder, MP, Cowley, T, London, D, Roberts, H, Butt, WR, and Griffiths, K. "In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones." Acta Endocrinol (Copenh) 82, no. 3 (July 1976): 561-571. Link to Item
  - Golder, MP, Millington, DS, Cowley, TH, Griffiths, K, Roberts, H, London, DR, and Butt, WR. "Proceedings: Hormonal control of steroid synthesis by a feminizing adrenal tumour." J Endocrinol 67, no. 2 (November 1975): 17P-. Link to Item
  - Millington, DS, Buoy, ME, Brooks, G, Harper, ME, and Griffiths, K. "Thin-layer chromatography and high resolution selected ion monitoring for the analysis of C19 steroids in human hyperplastic prostate tissue." Biological Mass Spectrometry 2, no. 4 (August 1975): 219-224. Full Text
  - Millington, DS. "Determination of hormonal steroid concentrations in biological extracts by high resolution mass fragmentography." J Steroid Biochem 6, no. 3-4 (March 1975): 239-245. Link to Item
  - Games, DE, Jackson, AH, Khan, NA, and Millington, DS. "Alkaloids of some African, Asian, Polynesian and Australian species of Erythrina." Lloydia 37, no. 4 (December 1974): 581-588. Link to Item
  - Hargreaves, RT, Johnson, RD, Millington, DS, Mondal, MH, Beavers, W, Becker, L, Young, C, and Rinehart, KL. "Alkaloids of American species of Erythrina." Lloydia 37, no. 4 (December 1974): 569-580. Link to Item
  - Millington, DS, Jones, T, Jenner, D, and Griffiths, K. "Proceedings: Measurement of endogenous steroid levels in human breast tumours by mass fragmentography." J Endocrinol 61, no. 2 (May 1974): LIV-LV. Link to Item
  - Millington, DS, Steinman, DH, and Rinehart, KL. "Isolation, gas chromatography-mass spectrometry, and structures of new alkaloids from Erythrina folkersii Krukoff and Moldenke and Erythrina salviiflora Krukoff and Barneby." J Am Chem Soc 96, no. 6 (March 20, 1974): 1909-1917. Link to Item
  - Games, DE, Jackson, AH, Millington, DS, and Rossiter, M. "The field ionization spectra of some natural coumarins." Biomed Mass Spectrom 1, no. 1 (February 1974): 5-9. Link to Item
  - Pandey, RC, Rinehart, KL, Millington, DS, and Swami, MB. "Letter: Polyene antibiotics. VI. The structures of dermostatins A and B." J Antibiot (Tokyo) 26, no. 8 (August 1973): 475-477. Link to Item
  - Stoll, MS, Elder, GH, Games, DE, O'Hanlon, P, Millington, DS, and Jackson, AH. "Isocoproporphyrin: nuclear-magnetic-resonance-and mass-spectral methods for the determination of porphyrin structure." Biochem J 131, no. 2 (February 1973): 429-432. Link to Item
  - Pandey, RC, Narasimhachari, N, Rinehart, KL, and Millington, DS. "Polyene antibiotics. IV. Structure of chainin." J Am Chem Soc 94, no. 12 (June 14, 1972): 4306-4310. Link to Item
  - Agarwal, KL, Johnstone, RA, Kenner, GW, Millington, DS, and Sheppard, RC. "Mass spectrometry of N-methylated peptide derivatives." Nature 219, no. 5153 (August 3, 1968): 498-499. Link to Item
- Book Sections
  - Young, S, Millington, D, and Klintworth, GK. "Disorders of amino acid metabolism." In Garner and Klintworth's Pathobiology of Ocular Disease Part B, Third Edition, 953-982. January 1, 2007.
  - Millington, DS, Sista, R, Bali, D, Eckhardt, AE, and Pamula, V. "Development of Biomarker Assays for Clinical Diagnostics Using a Digital Microfluidics Platform(Published online)." In Dried Blood Spots, 325-331.: John Wiley & Sons, Inc.,. Full Text
  - Millington, DS, Zhang, H, Moseley, MA, Thompson, JW, and Smith, P. "Direct Solvent Extraction and Analysis of Biomarkers in Dried Blood Spots Using a Flow-Through Autosampler(Published online)." In Dried Blood Spots, 314-324.: John Wiley & Sons, Inc.,. Full Text

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