Scholars@Duke
David Stuart Millington

David Stuart Millington

Professor Emeritus of Pediatrics
Pediatrics, Medical Genetics
milli014@duke.edu
Box 3028 Med Ctr, Durham 27710
801-6 Capitola Drive, Box 103856, Durham 27713

Overview

Development of new mass spectrometric methods for the analysis of disease-specific metabolites in human physiological fluids for application to the diagnosis of inborn errors of metabolism. The development of automated methods based on tandem mass spectrometry for the analysis of these metabolites in blood spots and urine from neonates, with a view to revolutionizing newborn screening methodology.
Development and application of mass spectrometry based biomarker assays for monitoring treatment and diagnosis of lysosomal storage diseases (LSDs).
Development and application of methods for analysis of drugs used in human clinical trials.
Application of "lab-on-a-chip" technology, based on digital microfluidics, to enzymatic and DNA- based assays used in newborn screening and at the point of care.
Development and application of new methods for studing clucose metabolism both in vivo and in vitro using stable isotope labeling with tandem mass spectrometry.
Development and application of methods for the analysis of urine markers of oxidative stress, using tandem mass spectrometry.

Current Appointments & Affiliations

Professor Emeritus of Pediatrics · 2015 - Present Pediatrics, Medical Genetics, Pediatrics

Education, Training & Certifications

University of Liverpool (United Kingdom) · 1969 Ph.D.