Donald Serafin | Scholars@Duke

Donald Serafin
Professor Emeritus of Surgery

Current Research Efforts: Working in collaboration with Bruce Klitzman, Ph.D., Director of the Plastic Surgery Research Laboratories, investigations continue on altering the thrombogenicity of microvascular prostheses. Efforts have been directed in reducing the thrombogenicity of (ePTFE) expanded polytetrafluroethylene vascular grafts utilizing hydrostatic pressure. Vascular prostheses were placed in saline under 6,000 psig hydrostatic pressure in an attempt to eliminate small pockets of gas known as gas nuclei trapped within the surface interstices of the graft material. By elimination of these gas nuclei thrombogenicity was significantly reduced.
In other studies it has been demonstrated that ePTFE treated grafts with TDMAC in Heparin also resulted in reduced thrombogenicity of the graft.
Other studies include the quantification of platelet emboli downstream from a vascular prosthesis, utilizing an isolated muscle technique which permits continuous monitoring of the microcirculation in the cremaster muscle. Current studies demonstrated that TDMAC Heparin on ePTFE microvascular prostheses not only improved graft patency rates but enhanced perfusion and reduced microemboli.
Ongoing investigations include the isolation and attachment of microvascular endothelial cells to ePTFE vascular graft material. Pretreatment of the graft material with denucleation and TDMAC with and without fibronectin demonstrated a highly significant retention of microvascular endothelial cells to the prosthesis. Current studies are underway to evaluate the degree to which these microvascular endothelial cells are metabolically active.

Current Appointments & Affiliations

Professor Emeritus of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery, Surgery 2000

Contact Information

300 Crutchfield, Durham, NC 27704
Box 3372 Med Ctr, Durham, NC 27710
donald.serafin@duke.edu (919) 684-3347

Background
Education, Training, & Certifications
- M.D., Duke University 1964
Duke Appointment History
- Consulting Professor in the Department of Surgery, Surgery, Section of Surgical Disciplines 2000 - 2012
- Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery, Surgery 1981 - 2000
- Chief, Division of Plastic and Maxillofacial in the Department of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery, Surgery 1985 - 1997
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kwon, H. B., D. I. Mackie, R. Bonnavion, A. L. Mercier, C. S. M. Helker, T. Son, S. Guenter, et al. “The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling.” Acs Pharmacology and Translational Science 3, no. 4 (August 14, 2020): 676–89. https://doi.org/10.1021/acsptsci.0c00020.
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  - Serafin, D Stephen, Natalie R. Harris, Natalie R. Nielsen, Duncan I. Mackie, and Kathleen M. Caron. “Dawn of a New RAMPage.” Trends Pharmacol Sci 41, no. 4 (April 2020): 249–65. https://doi.org/10.1016/j.tips.2020.01.009.
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  - Antonia, Ricardo J., Johnny Castillo, Laura E. Herring, D Stephen Serafin, Pengda Liu, Lee M. Graves, Albert S. Baldwin, and Robert S. Hagan. “TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877.” Sci Rep 9, no. 1 (September 17, 2019): 13470. https://doi.org/10.1038/s41598-019-49707-8.
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  - Serafin, D Stephen, Brittney Allyn, Maria F. Sassano, Roman G. Timoshchenko, Daniel Mattox, Jaime M. Brozowski, David P. Siderovski, et al. “Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.” Molecular Immunology 106 (February 2019): 12–21. https://doi.org/10.1016/j.molimm.2018.12.016.
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  - Nandedkar, Sanjeev D., Donald B. Sanders, Lisa D. Hobson-Webb, Santoshi Billlakota, Paul E. Barkhaus, and Erik V. Stalberg. “Reply.” Muscle Nerve 58, no. 4 (October 2018): E31–32. https://doi.org/10.1002/mus.26198.
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  - Mainz, Emilie R., D Stephen Serafin, Tuong T. Nguyen, Teresa K. Tarrant, Christopher E. Sims, and Nancy L. Allbritton. “Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.” Anal Chem 88, no. 15 (August 2, 2016): 7786–92. https://doi.org/10.1021/acs.analchem.6b01801.
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  - Billard, Matthew J., David J. Fitzhugh, Joel S. Parker, Jaime M. Brozowski, Marcus W. McGinnis, Roman G. Timoshchenko, D Stephen Serafin, et al. “G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.” Plos One 11, no. 4 (2016): e0152856. https://doi.org/10.1371/journal.pone.0152856.
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  - Rogers, Jennifer L., Donald S. Serafin, Roman G. Timoshchenko, and Teresa K. Tarrant. “Cellular targeting in autoimmunity.” Curr Allergy Asthma Rep 12, no. 6 (December 2012): 495–510. https://doi.org/10.1007/s11882-012-0307-y.
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  - Chi, B., D. Serafin, and W. O. Robertson. “Drug imprinting ('unit labeling')--an update and a plea!.” Veterinary and Human Toxicology 45, no. 1 (February 2003): 1–2.
  - Serafin, D. “Effect of warm ischemia on neovascularization of island flaps - Invited discussion.” Journal of Reconstructive Microsurgery 17, no. 8 (November 1, 2001): 650–51.
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  - Serafin, D. “Invited discussion.” Journal of Reconstructive Microsurgery 17, no. 8 (January 1, 2001): 650–51.
  - Ritter, E. F., J. C. Cronan, A. M. Rudner, D. Serafin, and B. Klitzman. “Improved microsurgical anastomotic patency with low molecular weight heparin.” J Reconstr Microsurg 14, no. 5 (July 1998): 331–36. https://doi.org/10.1055/s-2007-1000186.
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  - Ritter, E. F., Y. B. Kim, H. P. Reischl, D. Serafin, A. M. Rudner, and B. Klitzman. “Heparin coating of vascular prostheses reduces thromboemboli.” Surgery 122, no. 5 (November 1997): 888–92. https://doi.org/10.1016/s0039-6060(97)90329-9.
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  - Ritter, E. F., M. Axelrod, K. W. Minn, E. Eades, A. M. Rudner, D. Serafin, and B. Klitzman. “Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol.” Plast Reconstr Surg 100, no. 4 (September 1997): 973–80. https://doi.org/10.1097/00006534-199709001-00021.
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  - Viscardi, P. J., E. A. Page, H. G. Clark, D. Serafin, and B. Klitzman. “Iloprost in alginate decreases the thrombogenicity of expanded polytetrafluoroethylene.” J Reconstr Microsurg 13, no. 4 (May 1997): 303–6. https://doi.org/10.1055/s-2007-1000240.
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  - Heinz, T., J. Perfect, W. Schell, E. Ritter, G. Ruff, and D. Serafin. “Soft-tissue fungal infections: surgical management of 12 immunocompromised patients.” Plast Reconstr Surg 97, no. 7 (June 1996): 1391–99. https://doi.org/10.1097/00006534-199606000-00011.
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  - Ritter, E. F., J. P. Anthony, L. S. Levin, C. P. Demas, B. Klitzman, D. Skarada, and D. Serafin. “Microsurgical composite tissue transplantation at difficult recipient sites facilitated by preliminary installation of vein grafts as arteriovenous loops.” J Reconstr Microsurg 12, no. 4 (May 1996): 231–40. https://doi.org/10.1055/s-2007-1006482.
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  - Zavitsanos, G., L. Huang, W. Panza, D. Serafin, and B. Klitzman. “Limiting impairment of muscle function following ischemia and reperfusion in rabbits.” J Reconstr Microsurg 12, no. 3 (April 1996): 183–87. https://doi.org/10.1055/s-2007-1006474.
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  - Yuen, J. C., A. T. Zhou, D. Serafin, and G. S. Georgiade. “Long-term sequelae following median sternotomy wound infection and flap reconstruction.” Ann Plast Surg 35, no. 6 (December 1995): 585–89. https://doi.org/10.1097/00000637-199512000-00005.
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  - Kim, Y. B., H. P. Reisch, D. Serafin, and B. Klitzman. “Evaluation of the thrombogenecity of microvascular prosthesis by in vivo microscopy.” J Korean Med Sci 9, no. 5 (October 1994): 357–61. https://doi.org/10.3346/jkms.1994.9.5.357.
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  - Riski, J. E., R. M. Mason, and D. Serafin. “Contribution of prosthetic therapy in the management of nasopharyngeal stenosis following uvulopalatopharyngoplasty.” J Prosthet Dent 67, no. 2 (February 1992): 141–43. https://doi.org/10.1016/0022-3913(92)90443-e.
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  - Minn, K. W., D. Serafin, E. Mikat, and B. Klitzman. “Reconstruction of rat femoral veins with microvascular prostheses.” Plast Reconstr Surg 87, no. 3 (March 1991): 536–42. https://doi.org/10.1097/00006534-199103000-00022.
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  - Clinton, M. S., R. S. Sepka, D. Bristol, W. C. Pederson, W. J. Barwick, D. Serafin, and B. Klitzman. “Establishment of normal ranges of laser Doppler blood flow in autologous tissue transplants.” Plast Reconstr Surg 87, no. 2 (February 1991): 299–309. https://doi.org/10.1097/00006534-199102000-00012.
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  - Axelrod, M., D. Serafin, and B. Klitzman. “Ultraviolet light and free radicals: an immunologic theory of epidermal carcinogenesis.” Plast Reconstr Surg 86, no. 3 (September 1990): 582–93. https://doi.org/10.1097/00006534-199009000-00037.
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  - Goldberg, M., D. Serafin, and B. Klitzman. “Quantification of neutrophil adhesion to skeletal muscle venules following ischemia-reperfusion.” J Reconstr Microsurg 6, no. 3 (July 1990): 267–70. https://doi.org/10.1055/s-2007-1006829.
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  - Perona, B. P., J. V. Bartolome, R. S. Sepka, D. Serafin, and B. Klitzman. “Acute difluoromethylornithine treatment increases skin flap survival in rats.” Ann Plast Surg 25, no. 1 (July 1990): 26–28. https://doi.org/10.1097/00000637-199007000-00006.
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  - Eshbaugh, W. G., B. G. Forley, E. F. Ritter, D. Serafin, and B. Klitzman. “Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine.” Plast Reconstr Surg 85, no. 4 (April 1990): 593–96. https://doi.org/10.1097/00006534-199004000-00015.
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  - Burk, R. W., D. Serafin, and B. Klitzman. “Toxic effects of catecholamines on skin.” Plast Reconstr Surg 85, no. 1 (January 1990): 92–99. https://doi.org/10.1097/00006534-199001000-00016.
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  - SERAFIN, D. “THE INFERIOR GLUTEAL FREE FLAP IN BREAST RECONSTRUCTION.” Plastic and Reconstructive Surgery 84, no. 6 (December 1, 1989): 884–85.
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  - Simmons, R., D. Serafin, and K. McCarty. “Pathologic considerations in the high-risk breast patient.” Clin Plast Surg 15, no. 4 (October 1988): 655–65.
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  - Serafin, D. “Of medicine and the breast.” North Carolina Medical Journal 49, no. 5 (May 1988): 255–63.
  - Gelman, J., J. V. Bartolome, S. Jenkins, D. Serafin, S. M. Schanberg, and B. Klitzman. “Reduced cell death in skin flaps in rats treated with difluoromethylornithine.” Faseb J 1, no. 6 (December 1987): 474–77. https://doi.org/10.1096/fasebj.1.6.3119414.
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  - Huang, L., C. T. Privalle, D. Serafin, and B. Klitzman. “Increased survival of skin flaps by scavengers of superoxide radical.” Faseb J 1, no. 2 (August 1987): 129–32. https://doi.org/10.1096/fasebj.1.2.3038647.
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  - Jenkins, S. D., R. S. Sepka, W. J. Barwick, D. Serafin, and B. Klitzman. “Routine clinical use of laser Doppler flowmeter to monitor free tissue transfer: preliminary results.” J Reconstr Microsurg 3, no. 4 (July 1987): 281–83. https://doi.org/10.1055/s-2007-1006996.
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  - Riski, J. E., N. G. Georgiade, D. Serafin, W. Barwick, G. S. Georgiade, and R. Riefkohl. “The orticochea pharyngoplasty and primary palatoplasty: an evaluation.” Ann Plast Surg 18, no. 4 (April 1987): 303–9. https://doi.org/10.1097/00000637-198704000-00006.
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  - SERAFIN, D. “COMBINED TRANSPLANTATION OF FREE-TISSUES - DISCUSSION.” Plastic and Reconstructive Surgery 79, no. 2 (February 1, 1987): 234–36.
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  - BERNHARDT, P., R. SIMMONS, G. GEORGIADE, R. RIEFKOHL, N. GEORGIADE, D. SERAFIN, E. COX, and K. MCCARTY. “ATYPICAL PROLIFERATIVE LESIONS IN BREASTS CONTRALATERAL TO BREASTS RESECTED FOR CARCINOMA.” Laboratory Investigation 56, no. 1 (January 1, 1987): A6–A6.
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  - Serafín, D. “Discussion.” Plastic and Reconstructive Surgery 79, no. 2 (January 1, 1987): 234–36.
  - Riski, J. E., D. Serafin, R. Riefkohl, G. S. Georgiade, and N. G. Georgiade. “A rationale for modifying the site of insertion of the orticochea pharyngoplasty.” Plast Reconstr Surg 73, no. 6 (June 1984): 882–94. https://doi.org/10.1097/00006534-198406000-00003.
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  - Georgiade, G., N. Georgiade, R. Riefkohl, D. Serafin, and W. Barwick. “Breast reconstruction following mastectomy.” N C Med J 45, no. 2 (February 1984): 81–85.
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  - SERAFIN, D. “LATE NECROSIS OF A LATISSIMUS DORSI FREE FLAP - DISCUSSION.” Plastic and Reconstructive Surgery 74, no. 2 (January 1, 1984): 279–81.
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  - SERAFIN, D. “SUCCESSFUL REPLANTATION OF AN AMPUTATED UPPER LIP - DISCUSSION.” Plastic and Reconstructive Surgery 73, no. 4 (January 1, 1984): 669–70.
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  - Serafin, D. “Successful replantation of an amputated upper lip.” Plastic and Reconstructive Surgery 73, no. 4 (January 1, 1984): 669–70. https://doi.org/10.1097/00006534-198404000-00028.
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  - Serafin, D. “Late necrosis of a latissimus dorsi free flap.” Plastic and Reconstructive Surgery 74, no. 2 (January 1, 1984): 279–81. https://doi.org/10.1097/00006534-198408000-00019.
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  - Serafin, D., M. Dimond, and R. France. “Factitious vesicocutaneous fistula: an enigma in diagnosis and treatment.” Plast Reconstr Surg 72, no. 1 (July 1983): 81–89.
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  - Serafin, D., and V. E. Voci. “Reconstruction of the lower extremity. Microsurgical composite tissue transplantation.” Clin Plast Surg 10, no. 1 (January 1983): 55–72.
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  - Clodius, L., P. J. Smith, J. Bruna, and D. Serafin. “The lymphatics of the groin flap.” Ann Plast Surg 9, no. 6 (December 1982): 447–58. https://doi.org/10.1097/00000637-198212000-00001.
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  - Serafin, D., V. E. Voci, and N. G. Georgiade. “Microsurgical composite tissue transplantation: indications and technical considerations in breast reconstruction following mastectomy.” Plast Reconstr Surg 70, no. 1 (July 1982): 24–36.
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  - Barwick, W. J., D. J. Goodkind, and D. Serafin. “The free scapular flap.” Plast Reconstr Surg 69, no. 5 (May 1982): 779–87. https://doi.org/10.1097/00006534-198205000-00007.
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  - Georgiade, N., D. Serafin, G. Georgiade, and K. S. McCarty. “Subcutaneous mastectomy: an evolution of concept and technique.” Ann Plast Surg 8, no. 1 (January 1982): 8–19. https://doi.org/10.1097/00000637-198201000-00005.
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  - Serafin, D. “Free latissimus dorsi muscle flap coverage of an electrical burn of the lower extremity.” Plastic and Reconstructive Surgery 69, no. 1 (January 1, 1982): 129. https://doi.org/10.1097/00006534-198269010-00023.
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  - Serafin, D., M. DeLand, C. B. Lesesne, P. J. Smith, K. T. Noell, and N. Georgiade. “Reconstruction with vascularized composite tissue in patients with excessive injury following surgery and irradiation.” Ann Plast Surg 8, no. 1 (January 1982): 35–54. https://doi.org/10.1097/00000637-198201000-00008.
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  - Serafin, D., and N. Georgiade. “Nipple-areola reconstruction after mastectomy.” Ann Plast Surg 8, no. 1 (January 1982): 29–34. https://doi.org/10.1097/00000637-198201000-00007.
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  - Georgiade, N., G. Georgiade, D. Serafin, and R. Riefkohl. “Twenty-five year evaluation of external halo fixation for severe maxillofacial injuries.” Plast Reconstr Surg 68, no. 3 (September 1981): 444–47.
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  - Poletti, Luis S., and Donald Serafin. “Subcutaneous Flap as an Alternative to Venous Anastomosis in Replantation Surgery.” Plastic and Reconstructive Surgery 68, no. 2 (August 1981): 235–36. https://doi.org/10.1097/00006534-198108000-00021.
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  - Georgiade, G., R. Riefkohl, D. Serafin, and N. Georgiade. “A silent but lethal injury associated with facial trauma.” Plast Reconstr Surg 67, no. 5 (May 1981): 665–67. https://doi.org/10.1097/00006534-198105000-00018.
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  - Serafin, D., C. B. Lesesne, R. Y. Mullen, and N. G. Georgiade. “Transcutaneous PO2 monitoring for assessing viability and predicting survival of skin flaps: experimental and clinical correlations.” J Microsurg 2, no. 3 (March 1981): 165–78. https://doi.org/10.1002/micr.1920020303.
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  - Georgiade, N., G. Georgiade, D. Serafin, and R. Riefkohl. “Twenty–five year evaluation of external halo fixation for severe maxillofacial injuries.” Plastic and Reconstructive Surgery 68, no. 3 (January 1, 1981): 444–47. https://doi.org/10.1097/00006534-198109000-00040.
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  - Serafin, D. “Microsurgery: past, present, and future.” Plast Reconstr Surg 66, no. 5 (November 1980): 781–85.
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  - Serafin, D., R. Riefkohl, I. Thomas, and N. G. Georgiade. “Vascularized rib-periosteal and osteocutaneous reconstruction of the maxilla and mandible: an assessment.” Plast Reconstr Surg 66, no. 5 (November 1980): 718–27. https://doi.org/10.1097/00006534-198011000-00007.
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  - Georgiade, G., R. Riefkohl, D. Serafin, and N. Georgiade. “Use of skin staples in plastic surgery.” Ann Plast Surg 5, no. 4 (October 1980): 324–25. https://doi.org/10.1097/00000637-198010000-00014.
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  - Serafin, D., R. E. Sabatier, R. L. Morris, and N. G. Georgiade. “Reconstruction of the lower extremity with vascularized composite tissue: improved tissue survival and specific indications.” Plast Reconstr Surg 66, no. 2 (August 1980): 230–41. https://doi.org/10.1097/00006534-198008000-00012.
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  - Mendell, N. R., M. A. Spence, K. Gladstien, J. Brunette, A. Stevens, E. Clifford, N. Georgiade, K. L. Pickrell, D. Serafin, and G. W. Quinn. “Multifactorial/threshold models and their application to cleft lip and cleft palate.” Prog Clin Biol Res 46 (1980): 387–406.
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  - Serafin, D., and P. J. Smith. “Vascularized transplantation of skeletal muscle: a case report.” J Microsurg 1, no. 4 (January 1980): 259–66. https://doi.org/10.1002/micr.1920010403.
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  - Georgiade, N. G., D. Serafin, and W. Barwick. “Late development of hematoma around a breast implant, necessitating removal.” Plast Reconstr Surg 64, no. 5 (November 1979): 708–10.
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  - Serafin, D. “The nurse anesthetist, a changing role: past, present and future.” Aana J 47, no. 5 (October 1979): 533–36.
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  - Georgiade, N. G., D. Serafin, R. Morris, and G. Georgiade. “Reduction mammaplasty utilizing an inferior pedicle nipple-areolar flap.” Ann Plast Surg 3, no. 3 (September 1979): 211–18. https://doi.org/10.1097/00000637-197909000-00003.
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  - Georgiade, N. G., D. Serafin, R. Riefkohl, and G. S. Georgiade. “Is there a reduction mammaplasty for "all seasons?".” Plast Reconstr Surg 63, no. 6 (June 1979): 765–73.
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  - Serafin, D., and N. G. Georgiade. “Plastic surgery.” Jama 241, no. 13 (March 30, 1979): 1386–87.
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  - Serafin, D. “Invited commentary.” World Journal of Surgery 3, no. 1 (January 1, 1979): 125–26. https://doi.org/10.1007/BF01556400.
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  - Serafin, D., and N. G. Georgiade. “Transfer of free flaps to provide well-vascularized, thick cover for breast reconstructions after radical mastectomy.” Plast Reconstr Surg 62, no. 4 (October 1978): 527–36. https://doi.org/10.1097/00006534-197810000-00005.
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  - Serafin, D., and N. G. Georgiade. “Microsurgical composite tissue transplantation.” Ann Surg 187, no. 6 (June 1978): 620–28. https://doi.org/10.1097/00000658-197806000-00006.
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  - Serafin, D., N. G. Georgiade, K. S. Given, and R. M. Goldwyn. “Transfer of free flaps to provide well-vascularized, thick cover for breast reconstruction after radical mastectomy.” Plastic and Reconstructive Surgery 62, no. 5 (January 1, 1978): 777. https://doi.org/10.1097/00006534-197811000-00026.
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  - Serafin, D., A. Villarreal-Rios, and N. G. Georgiade. “A rib-containing free flap to reconstruct mandibular defects.” Br J Plast Surg 30, no. 4 (October 1977): 263–66. https://doi.org/10.1016/0007-1226(77)90113-8.
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  - Serafin, D., J. C. Shearin, and N. G. Georgiade. “The vascularization of free flaps: a clinical and experimental correlation.” Plast Reconstr Surg 60, no. 2 (August 1977): 233–41. https://doi.org/10.1097/00006534-197708000-00010.
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  - Serafin, D., and N. G. Georgiade. “Microsurgical composite tissue transplantation: a new method of immediate reconstruction of extensive defects.” Am J Surg 133, no. 6 (June 1977): 752–57. https://doi.org/10.1016/0002-9610(77)90172-6.
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  - Serafin, D., N. G. Georgiade, and D. H. Smith. “Comparison of free flaps with pedicled flaps for coverage of defects of the leg or foot.” Plast Reconstr Surg 59, no. 4 (April 1977): 492–99.
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  - Lanier, V. C., D. Serafin, H. F. Kleinert, J. E. Kutz, E. Atasoy, and G. Lister. “Microvascular procedures in reconstructive surgery.” South Med J 69, no. 12 (December 1976): 1595–97. https://doi.org/10.1097/00007611-197612000-00031.
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  - Serafin, D., C. L. Puckett, and G. McCarty. “Successful treatment of acute vascular insufficiency in a hand by intra-arterial fibrinolysin, heparin, and reserpine. Case report.” Plast Reconstr Surg 58, no. 4 (October 1976): 506–9. https://doi.org/10.1097/00006534-197610000-00025.
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  - Shearin, J. C., D. Serafin, and N. Georgiade. “Microvascular anastomosis: an experimental model utilizing the rabbit ear.” Plast Reconstr Surg 58, no. 4 (October 1976): 454–58.
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  - Serafin, D., N. G. Georgiade, and C. R. Peters. “Microsurgical composite tissue transplantation: a method of immediate reconstruction of the head and neck.” Clin Plast Surg 3, no. 3 (July 1976): 447–57.
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  - Serafin, D., A. V. Rios, and N. Georgiade. “Fourteen free groin flap transfers.” Plast Reconstr Surg 57, no. 6 (June 1976): 707–15. https://doi.org/10.1097/00006534-197606000-00005.
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  - Serafin, D., and N. G. Georgiade. “Microsurgical composite tissue transplantation: a new horizon in plastic and reconstructive surgery.” N C Med J 37, no. 5 (May 1976): 246–48.
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  - Serafin, D., J. E. Kutz, and H. E. Kleinert. “Replantation of a completely amputated distal thumb without venous anastomosis. Case report.” Plast Reconstr Surg 52, no. 5 (November 1973): 579–82. https://doi.org/10.1097/00006534-197311000-00024.
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  - Serafin, D., R. A. Vogel, and K. Given. “Intravascular coagulation--a source of possible error in carbon-clearance determinations.” J Surg Res 15, no. 5 (November 1973): 319–26. https://doi.org/10.1016/0022-4804(73)90095-4.
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  - Kleinert, H. E., D. Serafin, J. E. Kutz, and E. Atasoy. “Reimplantation of amputated digits and hands.” Orthop Clin North Am 4, no. 4 (October 1973): 957–67.
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  - Kleinert, H. E., D. Serafin, and R. K. Daniel. “The place of microsurgery in hand surgery.” Orthop Clin North Am 4, no. 4 (October 1973): 929–44.
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  - Serafin, D., H. H. Stone, L. D. Kolb, and J. D. Martin. “Alterations in reticulo-endothelial functions as produced by the administration of bacterial toxins.” Am Surg 34, no. 10 (October 1968): 714–16.
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  - McGarity, W. C., and D. Serafin. “Brucellosis. Indications for splenectomy.” Am J Surg 115, no. 3 (March 1968): 355–63. https://doi.org/10.1016/0002-9610(68)90160-8.
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- Other Articles
  - Forley, B. G., L. Huang, J. Bartolome, D. Serafin, and B. Klitzman. “The potential role of polyamine inhibition in keloid therapy.” Surgical Forum, January 1, 1988.
  - KLITZMAN, B., J. GELMAN, D. SERAFIN, R. SEPKA, S. SCHANBERG, and J. V. BARTOLOME. “PROTECTION OF RAT SKIN AGAINST ISCHEMIC DAMAGE WITH DIFLUOROMETHYLORNITHINE.” Federation Proceedings. FEDERATION AMER SOC EXP BIOL, March 5, 1987.
    Link to Item
  - KLITZMAN, B., N. SCHRADER, R. SEPKA, and D. SERAFIN. “RELATIVE EFFECTS OF RED-CELLS AND PLATELETS ON RAT SKIN FLAP SURVIVAL.” Federation Proceedings. FEDERATION AMER SOC EXP BIOL, March 5, 1987.
    Link to Item
  - Ball, R., D. Serafin, and B. Klitzman. “Rat skin flap necrosis reduced with topical chlorpromazine.” Surgical Forum, January 1, 1987.
  - KLITZMAN, B., R. S. SEPKA, and D. SERAFIN. “EFFECTS OF SYSTEMIC HEMATOCRIT ON RAT SKIN FLAP SURVIVAL.” Biorheology. PERGAMON-ELSEVIER SCIENCE LTD, January 1, 1986.
    Link to Item
- Conference Papers
  - HUSSEIN, M., S. ABDELALEEM, M. ELFALAKY, D. SERAFIN, and B. KLITZMAN. “CORRELATION BETWEEN SKELETAL-MUSCLE HIGH-ENERGY ADENINE-NUCLEOTIDE CONTENT AND APPLIED PRESSURE.” In Faseb Journal, 9:A693–A693. FEDERATION AMER SOC EXP BIOL, 1995.
    Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Publications

Academic Articles

Other Articles

Conference Papers