Donna Crenshaw | Scholars@Duke

Donna Crenshaw
Executive in Residence in the Pratt School of Engineering

Current Appointments & Affiliations

Executive in Residence in the Pratt School of Engineering, Pratt School of Engineering, Duke University 2016
Executive Team Member of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014

Contact Information

Box 90141, Durham, NC 27705
Room 260, 304 North Building, Research Drive, PO Box 90141, Durham, NC 27708
donna.crenshaw@duke.edu (919) 660-1915
Duke Center for Applied Genomics and Precision Medicine
Duke MEDx
LinkedIn Profile

Background
Education, Training, & Certifications
- M.H.A., University of North Carolina - Chapel Hill 2013
- Ph.D., Duke University 1993
Recognition
In the News
- OCT 1, 2021 Pratt School of Engineering
  
  A New Home for Innovation at the Pratt School
- APR 2, 2020
  
  Solving Pressing Challenges: 3D Printing of Medical Grade Face Shields
Research
External Relationships
- 3Silk, Inc
- Biomeme, Inc
- MeTree&You
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lutz, Michael W., Donna Crenshaw, Kathleen A. Welsh-Bohmer, Daniel K. Burns, and Allen D. Roses. “New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.” Curr Neurol Neurosci Rep 16, no. 5 (May 2016): 48. https://doi.org/10.1007/s11910-016-0643-8.
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  - Crenshaw, Donna G., Karen Asin, William K. Gottschalk, Zhifeng Liang, Nanyin Zhang, and Allen D. Roses. “Effects of low doses of pioglitazone on resting-state functional connectivity in conscious rat brain.” Plos One 10, no. 2 (2015): e0117973. https://doi.org/10.1371/journal.pone.0117973.
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  - Linnertz, Colton, Lauren Anderson, William Gottschalk, Donna Crenshaw, Michael W. Lutz, Jawara Allen, Sunita Saith, et al. “The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.” Alzheimers Dement 10, no. 5 (September 2014): 541–51. https://doi.org/10.1016/j.jalz.2013.08.280.
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  - Roses, Allen D., Ann M. Saunders, Michael W. Lutz, Nanyin Zhang, Ahmad R. Hariri, Karen E. Asin, Donna G. Crenshaw, Kumar Budur, Daniel K. Burns, and Stephen K. Brannan. “New applications of disease genetics and pharmacogenetics to drug development.” Curr Opin Pharmacol 14 (February 2014): 81–89. https://doi.org/10.1016/j.coph.2013.12.002.
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  - Roses, Allen D., Michael W. Lutz, Donna G. Crenshaw, Iris Grossman, Ann M. Saunders, and W Kirby Gottschalk. “TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.” Alzheimers Dement 9, no. 2 (March 2013): 132–36. https://doi.org/10.1016/j.jalz.2012.10.009.
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  - Crenshaw, D. G., W. K. Gottschalk, M. W. Lutz, I. Grossman, A. M. Saunders, J. R. Burke, K. A. Welsh-Bohmer, S. K. Brannan, D. K. Burns, and A. D. Roses. “Using genetics to enable studies on the prevention of Alzheimer's disease.” Clin Pharmacol Ther 93, no. 2 (February 2013): 177–85. https://doi.org/10.1038/clpt.2012.222.
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  - Linnertz, Colton, Ann M. Saunders, Michael W. Lutz, Donna M. Crenshaw, Iris Grossman, Daniel K. Burns, Keith E. Whitfield, et al. “Characterization of the poly-T variant in the TOMM40 gene in diverse populations.” Plos One 7, no. 2 (2012): e30994. https://doi.org/10.1371/journal.pone.0030994.
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  - Lutz, Michael W., Donna G. Crenshaw, Ann M. Saunders, and Allen D. Roses. “The importance of being connected.” J Alzheimers Dis 24, no. 2 (2011): 247–51. https://doi.org/10.3233/JAD-2010-101765.
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  - Roses, A. D., M. W. Lutz, H. Amrine-Madsen, A. M. Saunders, D. G. Crenshaw, S. S. Sundseth, M. J. Huentelman, K. A. Welsh-Bohmer, and E. M. Reiman. “A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.” Pharmacogenomics J 10, no. 5 (October 2010): 375–84. https://doi.org/10.1038/tpj.2009.69.
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  - Grossman, Iris, Michael W. Lutz, Donna G. Crenshaw, Ann M. Saunders, Daniel K. Burns, and Allen D. Roses. “Alzheimer's disease: diagnostics, prognostics and the road to prevention.” Epma J 1, no. 2 (June 2010): 293–303. https://doi.org/10.1007/s13167-010-0024-3.
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  - Lutz, Michael W., Donna G. Crenshaw, Ann M. Saunders, and Allen D. Roses. “Genetic variation at a single locus and age of onset for Alzheimer's disease.” Alzheimers Dement 6, no. 2 (March 2010): 125–31. https://doi.org/10.1016/j.jalz.2010.01.011.
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  - Akkari, P Anthony, Thomas W. Swanson, Donna G. Crenshaw, Iris Grossman, Scott Sundseth, Daniel K. Burns, and Allen D. Roses. “Pipeline pharmacogenetics: a novel approach to integrating pharmaco-genetics into drug development.” Current Pharmaceutical Design 15, no. 32 (January 2009): 3754–63. https://doi.org/10.2174/138161209789649538.
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  - Crenshaw, D. G., J. Yang, A. R. Means, and S. Kornbluth. “The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1.” Embo J 17, no. 5 (August 10, 1998): 1315–27. https://doi.org/10.1093/emboj/17.5.1315.
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  - Crenshaw, D. G., and T. Hsieh. “Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. I. In vitro studies.” J Biol Chem 268, no. 28 (October 5, 1993): 21328–34.
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  - Crenshaw, D. G., and T. Hsieh. “Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. II. In vivo studies.” J Biol Chem 268, no. 28 (October 5, 1993): 21335–43.
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  - Andrews, T John, Donna M. Greenwood, and David Yellowlees. “Catalytically active hybrids formed in vitro between large and small subunits of different procaryotic ribulose bisphosphate carboxylases.” Archives of Biochemistry and Biophysics 234, no. 1 (October 1984): 313–17. https://doi.org/10.1016/0003-9861(84)90354-0.
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- Book Sections
  - Means, Anthony R., Christina R. Karl, Donna G. Crenshaw, and Jennifer S. Dayton. “Traversing the cell cycle: The calcium/calmodulin connection.” In Calcium as a Cellular Regulator, edited by Ernesto Carafoli and Claude Klee, 512–28. New York: Oxford University Press, USA, 1999.
- Conference Papers
  - Budur, Kumar, Ferenc Martenyi, Kathleen A. Welsh-Bohmer, Daniel K. Burns, Carl Chiang, Janet O’Neil, Grant Runyan, et al. “A Pharmacogenetics Supported Clinical Trial to Delay Onset of Mild Cognitive Impairment due to Alzheimer's Disease Using Low Dose Pioglitazone: The Tommorrow Study.” In Neuropsychopharmacology, 39:S342–S342. NATURE PUBLISHING GROUP, 2014.
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  - HSIEH, T., M. LEE, D. CRENSHAW, S. BROWN, and A. CHEN. “STRUCTURES AND FUNCTIONS OF DNA TOPOISOMERASES.” In Journal of Cellular Biochemistry, 150–150. WILEY-LISS, 1993.
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  - CRENSHAW, D. G., and T. S. HSIEH. “CHARACTERIZATION OF THE FUNCTION OF THE CARBOXYL TERMINAL DOMAIN OF THE TYPE-II TOPOISOMERASE FROM DROSOPHILA-MELANOGASTER.” In Faseb Journal, 5:A811–A811. FEDERATION AMER SOC EXP BIOL, 1991.
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Education, Training, & Certifications

In the News

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers