Scholars@Duke
Edward Pritchett

Edward Pritchett

Adjunct Professor in the Department of Medicine
Medicine, Cardiology
ed.pritchett@edwardpritchett.com
Box 102359 Dumnc, Durham, NC 27715
PMB 333, 1821 Hillandale Rd, Ste 1B, Durham, NC 27705

Selected Publications

Randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a single oral dose of vanoxerine for the conversion of subjects with recent onset atrial fibrillation or flutter to normal sinus rhythm: RESTORE SR.

Journal Article Heart Rhythm · September 2016 BACKGROUND: Vanoxerine is an oral, 1,4-dialkylpiperazine derivative antiarrhythmic drug being evaluated for pharmacological cardioversion of atrial fibrillation (AF). OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of vanoxerin ... Full text Link to item Cite

Vernakalant hydrochloride for rapid conversion of atrial fibrillation: a phase 3, randomized, placebo-controlled trial.

Journal Article Circulation · March 25, 2008 BACKGROUND: The present study assessed the efficacy and safety of vernakalant hydrochloride (RSD1235), a novel compound, for the conversion of atrial fibrillation (AF). METHODS AND RESULTS: Patients were randomized in a 2:1 ratio to receive vernakalant or ... Full text Link to item Cite

Azimilide for the treatment of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia: results of a randomized trial and insights on the concordance of symptoms and recurrent arrhythmias.

Journal Article J Cardiovasc Electrophysiol · February 2008 INTRODUCTION: Azimilide hydrochloride is an investigational antiarrhythmic medication that had shown evidence of efficacy in prolonging the time to recurrence of atrial fibrillation (AF) or atrial flutter (AFL) and paroxysmal supraventricular tachycardia ( ... Full text Link to item Cite

Monitoring the ACTIVE-W trial: some issues in monitoring a noninferiority trial.

Journal Article Am Heart J · January 2008 Noninferiority comparisons of new to current therapies and the use of composite outcomes represent significant advances in the design of clinical trials. They increasingly characterize trials of new cardiovascular agents, posing new challenges to Data Safe ... Full text Link to item Cite

Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart disease.

Journal Article Am J Cardiol · July 15, 2006 Azimilide hydrochloride (azimilide), an investigational antiarrhythmic drug, has shown variable efficacy in preventing atrial fibrillation (AF). This study was designed to assess its efficacy in maintaining sinus rhythm in patients with paroxysmal AF and h ... Full text Link to item Cite

Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm.

Journal Article Am Heart J · May 2006 BACKGROUND: Azimilide dihydrochloride (azimilide) is an investigational antiarrhythmic drug that has been tested in patients with a variety of arrhythmias. In patients with atrial fibrillation, it has shown excellent efficacy in some previous trials and mi ... Full text Link to item Cite

Efficacy and safety of sustained-release propafenone (propafenone SR) for patients with atrial fibrillation.

Journal Article Am J Cardiol · October 15, 2003 The objective of this randomized, double-blind, placebo-controlled clinical trial was to test the efficacy and safety of a new sustained-release preparation of the antiarrhythmic drug propafenone (propafenone SR) in reducing the frequency of symptomatic ar ... Full text Link to item Cite

Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillation.

Journal Article J Clin Pharmacol · April 2002 The purpose of this study was to assess the effect of azimilide, a Class III antiarrhythmic drug, on ECG conduction intervals recorded during sinus rhythm in patients with a history of symptomatic atrial fibrillation or atrial flutter. In Phase I clinical ... Link to item Cite

Antiarrhythmic effects of azimilide in atrial fibrillation: efficacy and dose-response. Azimilide Supraventricular Arrhythmia Program 3 (SVA-3) Investigators.

Journal Article J Am Coll Cardiol · September 2000 OBJECTIVES: The purpose of this study was to assess the effectiveness of azimilide, a class III antiarrhythmic drug, in reducing the frequency of symptomatic arrhythmia recurrences in patients with atrial fibrillation, atrial flutter or both. BACKGROUND: A ... Full text Link to item Cite

Observations on the transition from intermittent to permanent atrial fibrillation.

Journal Article Am Heart J · July 2000 BACKGROUND: Quantitative data on the frequency with which transition from intermittent to permanent atrial fibrillation occurs are lacking. We conducted this study to determine the proportion of patients with intermittent atrial fibrillation who progress t ... Full text Link to item Cite

Effect of dofetilide on survival in patients with supraventricular arrhythmias.

Journal Article Am Heart J · November 1999 OBJECTIVES: This study compared survival between patients taking dofetilide and patients taking placebo in a pooled analysis of randomized clinical trials of patients with supraventricular arrhythmias. BACKGROUND: Clinical trials of antiarrhythmic drugs us ... Full text Link to item Cite

Clinical features of Wolff-Parkinson-White syndrome.

Journal Article Am Heart J · September 1999 Wolff-Parkinson-White syndrome is the most common form of ventricular preexcitation. Understanding this syndrome is fundamental for anyone interested in learning about arrhythmias. This review addresses (1) the historic sequence of events that led to the u ... Full text Link to item Cite

Cost effectiveness of inpatient initiation of antiarrhythmic therapy for supraventricular tachycardias.

Journal Article Am J Cardiol · December 15, 1997 This study assessed the cost effectiveness of inpatient antiarrhythmic therapy initiation for supraventricular tachycardias using a metaanalysis of proarrhythmic risk and a decision analysis that compared inpatient to outpatient therapy initiation. A MEDLI ... Full text Link to item Cite

Evaluation of the effect of transthoracic cardioversion from ventricular tachycardia to sinus rhythm on left atrial mechanical function.

Journal Article Am J Cardiol · December 15, 1996 We measured left atrial function during sinus rhythm before and after ventricular tachycardia was induced in an electrophysiology laboratory, using peak transmitral A-wave velocity from pulsed-Doppler transthoracic echocardiography as a marker of left atri ... Full text Link to item Cite

Heart rate during spontaneous and induced paroxysmal supraventricular tachycardia.

Journal Article Pacing Clin Electrophysiol · December 1995 It is generally assumed that paroxysmal supraventricular tachycardia (PSVT) induced during invasive electrophysiological study reproduces the patient's spontaneous, clinical arrhythmia. Even in the absence of antiarrhythmic drugs, however, there may be sig ... Full text Link to item Cite

Incidence of symptomatic atrial fibrillation in patients with paroxysmal supraventricular tachycardia.

Journal Article J Am Coll Cardiol · April 1995 OBJECTIVES: This study was performed to determine the incidence of symptomatic, sustained atrial fibrillation in a group of patients with paroxysmal supraventricular tachycardia. The effects of the mechanism of paroxysmal supraventricular tachycardia (atri ... Full text Link to item Cite

Flecainide acetate for paroxysmal supraventricular tachyarrhythmias. The Flecainide Supraventricular Tachycardia Study Group.

Journal Article Am J Cardiol · September 15, 1994 Flecainide has been shown to be effective in short-term, controlled studies for prevention of paroxysmal supraventricular tachycardia (SVT) and paroxysmal atrial fibrillation (AF). However, it is unknown whether this beneficial response is maintained durin ... Full text Link to item Cite

Evaluation of outpatients experiencing implantable cardioverter defibrillator shocks associated with minimal symptoms.

Journal Article Pacing Clin Electrophysiol · May 1994 Patients receiving minimally symptomatic shocks from their implantable cardioverter defibrillators were studied prospectively using transtelephonic ECG loop monitoring. The time course to the first subsequent shock was evaluated. Twenty-nine consecutive pa ... Full text Link to item Cite

A system for the analysis of long-term electrocardiographic studies in clinical research and training.

Journal Article Comput Biomed Res · August 1983 A computer system has been developed for the analysis of data from long-term electrocardiographic studies in the context of an institution committed to clinical research and training. The major characteristics required of such a system are intelligence, fl ... Full text Link to item Cite

High-performance liquid chromatographic analysis of diltiazem and its metabolite in plasma.

Journal Article J Chromatogr · January 14, 1983 A rapid, selective and reproducible high-performance liquid chromatographic method for the analysis in plasma of the calcium channel blocking agent, diltiazem, and one of its metabolites, deacetyldiltiazem is described. The method involves extraction with ... Full text Link to item Cite

Effect of verapamil on left ventricular function at rest and during exercise in normal men.

Journal Article J Cardiovasc Pharmacol · 1983 Verapamil is a calcium channel blocking agent used primarily for treatment of arrhythmias and coronary artery disease. It may also depress myocardial contractility. The purpose of this study was to assess the effect of verapamil on left ventricular functio ... Full text Link to item Cite

Hemodynamic effects of the antiarrhythmic drug pirmenol.

Journal Article Clin Pharmacol Ther · August 1982 We examined the hemodynamic effects of pirmenol, a new antiarrhythmic drug, for the first time in man. Right and left heart pressures, Fick cardiac output, and radionuclide ejection fraction were measured before and during infusion of pirmenol in 10 patien ... Full text Link to item Cite

DETECTION AND MECHANISMS OF ARRHYTHMOGENIC EPILEPSY - REPLY

Journal Article AMERICAN HEART JOURNAL · 1981 Full text Cite

Arrhythmogenic epilepsy: an hypothesis.

Journal Article Am Heart J · November 1980 This report describes a clinical syndrome of arrhythmias that may have neural origin. Two patients presented with episodes of loss of consciousness, disorientation, and paroxysmal supraventricular tachycardia (PSVT). One patient reported experiencing neuro ... Full text Link to item Cite

Ventricular fibrillation in the Wolff-Parkinson-White syndrome.

Journal Article N Engl J Med · November 15, 1979 To examine the risk of ventricular fibrillation in patients with the Wolff-Parkinson-White syndrome, we compared patients who had this syndrome and a history of ventricular fibrillation related to preexcitation with patients who had the syndrome without th ... Full text Link to item Cite

The preexcitation syndromes.

Journal Article Prog Cardiovasc Dis · 1978 Current methodology permits one to define the functional basis of the preexcitation syndromes with reasonable certainty and to develop a rationale for instituting trials of medical therapy. Future studies will hopefully result in a more exact definition of ... Full text Link to item Cite

Atrial fibrillation in the preexcitation syndrome.

Journal Article Am J Cardiol · October 1977 One hundred patients with proved accessory pathways of the Kent bundle type were studied with multiple intracardiac catheters. During the procedure 16 had atrial fibrillation. Two patterns of induction of atrial fibrillation were noted. In most patients an ... Full text Link to item Cite