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Edina Wang

Adjunct Associate in the Department of Radiation Oncology
Radiation Oncology

Selected Publications


Second generation anti-androgens and androgen deprivation therapy with radiation therapy in the definitive management of high-risk prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · March 2023 BACKGROUND: Evolving data suggest that men with high-risk localized prostate cancer may benefit from more potent androgen receptor inhibition in the context of curative intent radiotherapy. Recently updated American Society for Clinical Oncology (ASCO) evi ... Full text Link to item Cite

Prostate MRI in Stereotactic Body Radiation Treatment Planning and Delivery for Localized Prostate Cancer.

Journal Article Radiographics · 2022 Prostate MRI is increasingly being used to make diagnoses and guide management for patients receiving definitive radiation treatment for prostate cancer. Radiologists should be familiar with the potential uses of prostate MRI in radiation therapy planning ... Full text Link to item Cite

Rationale for Involved Field Stereotactic Body Radiation Therapy-Enhanced Intermittent Androgen Deprivation Therapy in Hormone-Sensitive Nodal Oligo-Recurrent Prostate Cancer Following Prostate Stereotactic Body Radiation Therapy.

Journal Article Front Oncol · 2020 Lymph node recurrent prostate cancer is a common clinical scenario that is likely to increase significantly with the widespread adoption of novel positron emission tomography (PET) agents. Despite increasing evidence that localized therapy is disease modif ... Full text Link to item Cite

Ten-Year Single Institutional Analysis of Geographic and Demographic Characteristics of Patients Treated With Stereotactic Body Radiation Therapy for Localized Prostate Cancer.

Journal Article Front Oncol · 2020 OBJECTIVES: Stereotactic Body Radiation Therapy (SBRT) offers definitive treatment for localized prostate cancer with comparable efficacy and toxicity to conventionally fractionated radiotherapy. Decreasing the number of treatment visits from over 40 to fi ... Full text Link to item Cite

Novel Coronavirus International Public Health Emergency: Guidance on Radiation Oncology Facility Operation.

Journal Article Adv Radiat Oncol · 2020 PURPOSE: The current situation of coronavirus disease 2019 (COVID-19) is rapidly evolving. Radiation therapy facilities are places of concentrated patient interactions. Oncology patients with immunosuppression are at a higher risk for contracting severe ac ... Full text Link to item Cite

Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases.

Journal Article J Clin Neurosci · September 2017 PURPOSE: Prior studies suggest a high incidence of leptomeningeal failure (LMF) in breast cancer metastatic to brain. This study examines breast cancer-specific variables affecting development of LMF and survival after Gamma-Knife Radiosurgery (GKS). METHO ... Full text Link to item Cite

Gamma Knife radiosurgery for brain metastases from gastrointestinal primary.

Journal Article J Med Imaging Radiat Oncol · August 2017 INTRODUCTION: In this study, we assessed clinical outcomes of patients with brain metastases from a gastrointestinal (GI) primary cancer and patterns of failure after stereotactic radiosurgery including failure within the radiosurgical volume, distant fail ... Full text Link to item Cite

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy.

Journal Article Biofabrication · June 7, 2017 Despite having yielded extensive breakthroughs in cancer research, traditional 2D cell cultures have limitations in studying cancer progression and metastasis and screening therapeutic candidates. 3D systems can allow cells to grow, migrate, and interact w ... Full text Link to item Cite

Artist's Statement: Reflection.

Journal Article Acad Med · December 2016 Full text Link to item Cite

Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.

Journal Article Nanoscale · December 21, 2015 Radiotherapy is a key component of cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic index of radiotherapy. DNA double-strand repair inhibitors (DSBRIs) are amon ... Full text Link to item Cite

Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors.

Journal Article Biomaterials · May 2015 Histone deacetylase inhibitors (HDACIs) represent a class of promising agents that can improve radiotherapy in cancer treatment. However, the full therapeutic potential of HDACIs as radiosensitizers has been restricted by limited efficacy in solid malignan ... Full text Link to item Cite

Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity.

Journal Article Nanoscale · February 14, 2015 Chemosensitizers can improve the therapeutic index of chemotherapy and overcome treatment resistance. Successful translation of chemosensitizers depends on the development of strategies that can preferentially deliver chemosensitizers to tumors while avoid ... Full text Link to item Cite

Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity.

Journal Article Nanoscale · February 21, 2014 The effects of nanoparticle (NP) properties, such as size, shape and surface charge, on their efficacy and toxicity have been studied extensively. However, the effect of controlled drug release on NP efficacy and toxicity has not been thoroughly evaluated ... Full text Link to item Cite

Differential cell responses to nanoparticle docetaxel and small molecule docetaxel at a sub-therapeutic dose range.

Journal Article Nanomedicine · February 2014 UNLABELLED: Current preclinical evaluations of nanoparticle taxanes have focused on the effect of nanoparticle size and shape on the efficacy and toxicity. It is generally assumed that nanoparticle therapeutics have the same cellular response on tumor and ... Full text Link to item Cite

Nanoparticles and their applications in cell and molecular biology.

Journal Article Integr Biol (Camb) · January 2014 Nanoparticles can be engineered with distinctive composition, size, shape, and surface chemistry to enable novel techniques in a wide range of biological applications. The unique properties of nanoparticles and their behavior in biological milieu also enab ... Full text Link to item Cite

Preclinical evaluation of Genexol-PM, a nanoparticle formulation of paclitaxel, as a novel radiosensitizer for the treatment of non-small cell lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2013 PURPOSE: A key research objective in radiation oncology is to identify agents that can improve chemoradiation therapy. Nanoparticle (NP) chemotherapeutics possess several properties, such as preferential accumulation in tumors, that are uniquely suited for ... Full text Link to item Cite

Abstract 4517: Differential cellular response to nanoparticle docetaxel and docetaxel at sub-therapeutic dose range.

Journal Article Cancer Research · April 15, 2013 AbstractNanoparticle (NP) formulations of taxanes overcome the need for excipients and improve the delivery of taxane therapeutics to tumors. These advantages have resulted in rapid clinical translation of N ... Full text Cite

Abstract 4522: Nanoparticle chemosensitization.

Journal Article Cancer Research · April 15, 2013 AbstractSystemic drug toxicity and multi-drug resistance are the two major obstacles in the treatment of cancer. While multi-drug resistance can be easily overcome by the use of chemosensitizers, the process ... Full text Cite

Abstract 4530: Nanoparticle formulation of KU55933 as a potent radiosensitizer.

Journal Article Cancer Research · April 15, 2013 AbstractKU55933 is a potent and specific inhibitor of the Ataxia Telangiectasia Mutated (ATM) protein. Given ATM's critical role in DNA damage repair, specifically double-strand break repair, KU55933 holds h ... Full text Cite

Second generation anti-androgens and androgen deprivation therapy with radiation therapy in the definitive management of high-risk prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · March 2023 BACKGROUND: Evolving data suggest that men with high-risk localized prostate cancer may benefit from more potent androgen receptor inhibition in the context of curative intent radiotherapy. Recently updated American Society for Clinical Oncology (ASCO) evi ... Full text Link to item Cite

Prostate MRI in Stereotactic Body Radiation Treatment Planning and Delivery for Localized Prostate Cancer.

Journal Article Radiographics · 2022 Prostate MRI is increasingly being used to make diagnoses and guide management for patients receiving definitive radiation treatment for prostate cancer. Radiologists should be familiar with the potential uses of prostate MRI in radiation therapy planning ... Full text Link to item Cite

Rationale for Involved Field Stereotactic Body Radiation Therapy-Enhanced Intermittent Androgen Deprivation Therapy in Hormone-Sensitive Nodal Oligo-Recurrent Prostate Cancer Following Prostate Stereotactic Body Radiation Therapy.

Journal Article Front Oncol · 2020 Lymph node recurrent prostate cancer is a common clinical scenario that is likely to increase significantly with the widespread adoption of novel positron emission tomography (PET) agents. Despite increasing evidence that localized therapy is disease modif ... Full text Link to item Cite

Ten-Year Single Institutional Analysis of Geographic and Demographic Characteristics of Patients Treated With Stereotactic Body Radiation Therapy for Localized Prostate Cancer.

Journal Article Front Oncol · 2020 OBJECTIVES: Stereotactic Body Radiation Therapy (SBRT) offers definitive treatment for localized prostate cancer with comparable efficacy and toxicity to conventionally fractionated radiotherapy. Decreasing the number of treatment visits from over 40 to fi ... Full text Link to item Cite

Novel Coronavirus International Public Health Emergency: Guidance on Radiation Oncology Facility Operation.

Journal Article Adv Radiat Oncol · 2020 PURPOSE: The current situation of coronavirus disease 2019 (COVID-19) is rapidly evolving. Radiation therapy facilities are places of concentrated patient interactions. Oncology patients with immunosuppression are at a higher risk for contracting severe ac ... Full text Link to item Cite

Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases.

Journal Article J Clin Neurosci · September 2017 PURPOSE: Prior studies suggest a high incidence of leptomeningeal failure (LMF) in breast cancer metastatic to brain. This study examines breast cancer-specific variables affecting development of LMF and survival after Gamma-Knife Radiosurgery (GKS). METHO ... Full text Link to item Cite

Gamma Knife radiosurgery for brain metastases from gastrointestinal primary.

Journal Article J Med Imaging Radiat Oncol · August 2017 INTRODUCTION: In this study, we assessed clinical outcomes of patients with brain metastases from a gastrointestinal (GI) primary cancer and patterns of failure after stereotactic radiosurgery including failure within the radiosurgical volume, distant fail ... Full text Link to item Cite

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy.

Journal Article Biofabrication · June 7, 2017 Despite having yielded extensive breakthroughs in cancer research, traditional 2D cell cultures have limitations in studying cancer progression and metastasis and screening therapeutic candidates. 3D systems can allow cells to grow, migrate, and interact w ... Full text Link to item Cite

Artist's Statement: Reflection.

Journal Article Acad Med · December 2016 Full text Link to item Cite

Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.

Journal Article Nanoscale · December 21, 2015 Radiotherapy is a key component of cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic index of radiotherapy. DNA double-strand repair inhibitors (DSBRIs) are amon ... Full text Link to item Cite

Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors.

Journal Article Biomaterials · May 2015 Histone deacetylase inhibitors (HDACIs) represent a class of promising agents that can improve radiotherapy in cancer treatment. However, the full therapeutic potential of HDACIs as radiosensitizers has been restricted by limited efficacy in solid malignan ... Full text Link to item Cite

Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity.

Journal Article Nanoscale · February 14, 2015 Chemosensitizers can improve the therapeutic index of chemotherapy and overcome treatment resistance. Successful translation of chemosensitizers depends on the development of strategies that can preferentially deliver chemosensitizers to tumors while avoid ... Full text Link to item Cite

Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity.

Journal Article Nanoscale · February 21, 2014 The effects of nanoparticle (NP) properties, such as size, shape and surface charge, on their efficacy and toxicity have been studied extensively. However, the effect of controlled drug release on NP efficacy and toxicity has not been thoroughly evaluated ... Full text Link to item Cite

Differential cell responses to nanoparticle docetaxel and small molecule docetaxel at a sub-therapeutic dose range.

Journal Article Nanomedicine · February 2014 UNLABELLED: Current preclinical evaluations of nanoparticle taxanes have focused on the effect of nanoparticle size and shape on the efficacy and toxicity. It is generally assumed that nanoparticle therapeutics have the same cellular response on tumor and ... Full text Link to item Cite

Nanoparticles and their applications in cell and molecular biology.

Journal Article Integr Biol (Camb) · January 2014 Nanoparticles can be engineered with distinctive composition, size, shape, and surface chemistry to enable novel techniques in a wide range of biological applications. The unique properties of nanoparticles and their behavior in biological milieu also enab ... Full text Link to item Cite

Preclinical evaluation of Genexol-PM, a nanoparticle formulation of paclitaxel, as a novel radiosensitizer for the treatment of non-small cell lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2013 PURPOSE: A key research objective in radiation oncology is to identify agents that can improve chemoradiation therapy. Nanoparticle (NP) chemotherapeutics possess several properties, such as preferential accumulation in tumors, that are uniquely suited for ... Full text Link to item Cite

Abstract 4517: Differential cellular response to nanoparticle docetaxel and docetaxel at sub-therapeutic dose range.

Journal Article Cancer Research · April 15, 2013 AbstractNanoparticle (NP) formulations of taxanes overcome the need for excipients and improve the delivery of taxane therapeutics to tumors. These advantages have resulted in rapid clinical translation of N ... Full text Cite

Abstract 4522: Nanoparticle chemosensitization.

Journal Article Cancer Research · April 15, 2013 AbstractSystemic drug toxicity and multi-drug resistance are the two major obstacles in the treatment of cancer. While multi-drug resistance can be easily overcome by the use of chemosensitizers, the process ... Full text Cite

Abstract 4530: Nanoparticle formulation of KU55933 as a potent radiosensitizer.

Journal Article Cancer Research · April 15, 2013 AbstractKU55933 is a potent and specific inhibitor of the Ataxia Telangiectasia Mutated (ATM) protein. Given ATM's critical role in DNA damage repair, specifically double-strand break repair, KU55933 holds h ... Full text Cite

Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery.

Journal Article Proc Natl Acad Sci U S A · May 22, 2012 One of the promises of nanoparticle (NP) carriers is the reformulation of promising therapeutics that have failed clinical development due to pharmacologic challenges. However, current nanomedicine research has been focused on the delivery of established a ... Full text Link to item Cite

Formulation of diblock polymeric nanoparticles through nanoprecipitation technique.

Journal Article J Vis Exp · September 20, 2011 Nanotechnology is a relatively new branch of science that involves harnessing the unique properties of particles that are nanometers in scale (nanoparticles). Nanoparticles can be engineered in a precise fashion where their size, composition and surface ch ... Full text Link to item Cite