Journal ArticleProstate Cancer Prostatic Dis · March 2023
BACKGROUND: Evolving data suggest that men with high-risk localized prostate cancer may benefit from more potent androgen receptor inhibition in the context of curative intent radiotherapy. Recently updated American Society for Clinical Oncology (ASCO) evi ...
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Journal ArticleRadiographics · 2022
Prostate MRI is increasingly being used to make diagnoses and guide management for patients receiving definitive radiation treatment for prostate cancer. Radiologists should be familiar with the potential uses of prostate MRI in radiation therapy planning ...
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Journal ArticleFront Oncol · 2020
Lymph node recurrent prostate cancer is a common clinical scenario that is likely to increase significantly with the widespread adoption of novel positron emission tomography (PET) agents. Despite increasing evidence that localized therapy is disease modif ...
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Journal ArticleFront Oncol · 2020
OBJECTIVES: Stereotactic Body Radiation Therapy (SBRT) offers definitive treatment for localized prostate cancer with comparable efficacy and toxicity to conventionally fractionated radiotherapy. Decreasing the number of treatment visits from over 40 to fi ...
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Journal ArticleAdv Radiat Oncol · 2020
PURPOSE: The current situation of coronavirus disease 2019 (COVID-19) is rapidly evolving. Radiation therapy facilities are places of concentrated patient interactions. Oncology patients with immunosuppression are at a higher risk for contracting severe ac ...
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Journal ArticleJ Clin Neurosci · September 2017
PURPOSE: Prior studies suggest a high incidence of leptomeningeal failure (LMF) in breast cancer metastatic to brain. This study examines breast cancer-specific variables affecting development of LMF and survival after Gamma-Knife Radiosurgery (GKS). METHO ...
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Journal ArticleJ Med Imaging Radiat Oncol · August 2017
INTRODUCTION: In this study, we assessed clinical outcomes of patients with brain metastases from a gastrointestinal (GI) primary cancer and patterns of failure after stereotactic radiosurgery including failure within the radiosurgical volume, distant fail ...
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Journal ArticleBiofabrication · June 7, 2017
Despite having yielded extensive breakthroughs in cancer research, traditional 2D cell cultures have limitations in studying cancer progression and metastasis and screening therapeutic candidates. 3D systems can allow cells to grow, migrate, and interact w ...
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Journal ArticleNanoscale · December 21, 2015
Radiotherapy is a key component of cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic index of radiotherapy. DNA double-strand repair inhibitors (DSBRIs) are amon ...
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Journal ArticleBiomaterials · May 2015
Histone deacetylase inhibitors (HDACIs) represent a class of promising agents that can improve radiotherapy in cancer treatment. However, the full therapeutic potential of HDACIs as radiosensitizers has been restricted by limited efficacy in solid malignan ...
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Journal ArticleNanoscale · February 14, 2015
Chemosensitizers can improve the therapeutic index of chemotherapy and overcome treatment resistance. Successful translation of chemosensitizers depends on the development of strategies that can preferentially deliver chemosensitizers to tumors while avoid ...
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Journal ArticleNanoscale · February 21, 2014
The effects of nanoparticle (NP) properties, such as size, shape and surface charge, on their efficacy and toxicity have been studied extensively. However, the effect of controlled drug release on NP efficacy and toxicity has not been thoroughly evaluated ...
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Journal ArticleNanomedicine · February 2014
UNLABELLED: Current preclinical evaluations of nanoparticle taxanes have focused on the effect of nanoparticle size and shape on the efficacy and toxicity. It is generally assumed that nanoparticle therapeutics have the same cellular response on tumor and ...
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Journal ArticleIntegr Biol (Camb) · January 2014
Nanoparticles can be engineered with distinctive composition, size, shape, and surface chemistry to enable novel techniques in a wide range of biological applications. The unique properties of nanoparticles and their behavior in biological milieu also enab ...
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Journal ArticleInt J Radiat Oncol Biol Phys · July 1, 2013
PURPOSE: A key research objective in radiation oncology is to identify agents that can improve chemoradiation therapy. Nanoparticle (NP) chemotherapeutics possess several properties, such as preferential accumulation in tumors, that are uniquely suited for ...
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Journal ArticleCancer Research · April 15, 2013
AbstractNanoparticle (NP) formulations of taxanes overcome the need for excipients and improve the delivery of taxane therapeutics to tumors. These advantages have resulted in rapid clinical translation of N ...
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Journal ArticleCancer Research · April 15, 2013
AbstractSystemic drug toxicity and multi-drug resistance are the two major obstacles in the treatment of cancer. While multi-drug resistance can be easily overcome by the use of chemosensitizers, the process ...
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Journal ArticleCancer Research · April 15, 2013
AbstractKU55933 is a potent and specific inhibitor of the Ataxia Telangiectasia Mutated (ATM) protein. Given ATM's critical role in DNA damage repair, specifically double-strand break repair, KU55933 holds h ...
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Journal ArticleProc Natl Acad Sci U S A · May 22, 2012
One of the promises of nanoparticle (NP) carriers is the reformulation of promising therapeutics that have failed clinical development due to pharmacologic challenges. However, current nanomedicine research has been focused on the delivery of established a ...
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Journal ArticleJ Vis Exp · September 20, 2011
Nanotechnology is a relatively new branch of science that involves harnessing the unique properties of particles that are nanometers in scale (nanoparticles). Nanoparticles can be engineered in a precise fashion where their size, composition and surface ch ...
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