Edmund Hilton Jooste | Scholars@Duke

Edmund Hilton Jooste
Associate Professor of Anesthesiology

Dr Jooste’s initial research focus was in the investigation of the smooth muscle airway effects of various non-depolarizing muscle relaxants. Recently, Dr Jooste has been involved in clinical research, investigating the pharmacokinetics and pharmacodynamics of anesthetic agents in children and in particular the cardiovascular effects of dexmedetomidine. His clinical practice focuses on the anesthesia care of children with congenital cardiac disease.

Current Appointments & Affiliations

Associate Professor of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2011
Associate Professor in Pediatrics, Pediatrics, Clinical Science Departments 2012

Contact Information

edmund.jooste@duke.edu

Background
Education, Training, & Certifications
- M.B.B.S., University of Pretoria (South Africa) 1995
Duke Appointment History
- Instructor Temporary in the Department of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2011
Research
Selected Grants
- ATIII Coagulation System in Infants-Investigator Led Study Agreement awarded by Grifols USA, LLC 2014 - 2016
Publications & Artistic Works
Selected Publications
- Book Sections
  - Ames, W, Hill, K, and Jooste, EH. "Anesthesia in the cardiac catheterization laboratory and MRI." In Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care, 721-741. January 1, 2014. Full Text
- Journal Articles
  - Jooste, EH, and Machovec, KA. "It is Time to Stop Missing the Forest for the Trees: The Debate on Corticosteroid Use in Pediatric Heart Surgery." Journal of cardiothoracic and vascular anesthesia 31, no. 6 (December 2017): 1957-1959. Full Text
  - Alberts, M, Groom, RC, Walczak, R, Kramer, R, Karpiel, A, Dieter, J, Sheth, L, Greene, NH, and Jooste, EH. "In Vitro Evaluation of the Fresenius Kabi CATSmart Autotransfusion System." The journal of extra-corporeal technology 49, no. 2 (June 2017): 107-111.
  - Tew, S, Fontes, ML, Greene, NH, Kertai, MD, Ofori-Amanfo, G, Jaquiss, RDB, Lodge, AJ, Ames, WA, Homi, HM, Machovec, KA, and Jooste, EH. "Natural history of nonimmune-mediated thrombocytopenia and acute kidney injury in pediatric open-heart surgery." Paediatric anaesthesia 27, no. 3 (March 2017): 305-313. Full Text
  - Jooste, EH, Hammer, GB, Reyes, CR, Katkade, V, and Szmuk, P. "Phase IV, Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Patients Undergoing Procedure-Type Sedation." Frontiers in pharmacology 8 (January 2017): 529-. Full Text
  - Jooste, EH, Machovec, KA, Einhorn, LM, Ames, WA, Homi, HM, Jaquiss, RDB, Lodge, AJ, Levy, JH, and Welsby, IJ. "3-Factor Prothrombin Complex Concentrates in Infants With Refractory Bleeding After Cardiac Surgery." Journal of cardiothoracic and vascular anesthesia 30, no. 6 (December 2016): 1627-1631. Full Text
  - Amhaz, HH, Buretta, K, Jooste, EH, Machovec, K, Marcus, JR, and Ames, WA. "Upper Extremity Peripheral Intravenous Line Infiltration With Concomitant Loss of Pulses Treated With Lipoaspiration: A Case Report." A & A case reports 7, no. 9 (November 2016): 185-187. Full Text
  - Machovec, KA, Smigla, G, Ames, WA, Schwimer, C, Homi, HM, Dhakal, IB, Jaquiss, RDB, Lodge, AJ, and Jooste, EH. "Reduction in blood transfusion in a cohort of infants having cardiac surgery with cardiopulmonary bypass after instituting a goal-directed transfusion policy." Perfusion 31, no. 7 (October 2016): 598-603. Full Text
  - Machovec, KA, Jaquiss, RDB, Kaemmer, DD, Ames, WA, Homi, HM, Walczak, RJ, Lodge, AJ, and Jooste, EH. "Cardiopulmonary Bypass Strategy for a Cyanotic Child With Hemoglobin SC Disease." The Annals of thoracic surgery 101, no. 6 (June 2016): 2373-2375. Full Text
  - McCartney, SL, Machovec, K, and Jooste, EH. "Uncorrected Tetralogy of Fallot, Biventricular Dysfunction, and a Large Pericardial Effusion." Journal of cardiothoracic and vascular anesthesia 29, no. 5 (October 2015): 1391-1395. Full Text Open Access Copy
  - Machovec, KA, Jooste, EH, Walczak, RJ, Homi, HM, Jaquiss, RDB, Lodge, AJ, and Ames, WA. "A change in anticoagulation monitoring improves safety, reduces transfusion, and reduces costs in infants on cardiopulmonary bypass." Paediatric anaesthesia 25, no. 6 (June 2015): 580-586. Full Text
  - Machovec, KA, Jooste, EH, and Ames, WA. "Ventricular pacing for induced hypotension in a toddler." A & A case reports 3, no. 3 (August 2014): 38-39. Full Text
  - Yang, CI, Fine, GF, Jooste, EH, Mutich, R, Walczak, SA, and Motoyama, EK. "The effect of cisatracurium and rocuronium on lung function in anesthetized children." Anesth Analg 117, no. 6 (December 2013): 1393-1400. Full Text Link to Item
  - Jooste, EH, Haft, WA, Ames, WA, Sherman, FS, and Vallejo, MC. "Anesthetic care of parturients with single ventricle physiology." J Clin Anesth 25, no. 5 (August 2013): 417-423. (Review) Full Text Link to Item
  - Chrysostomou, C, Morell, VO, Wearden, P, Sanchez-de-Toledo, J, Jooste, EH, and Beerman, L. "Dexmedetomidine: therapeutic use for the termination of reentrant supraventricular tachycardia." Congenit Heart Dis 8, no. 1 (January 2013): 48-56. Full Text Link to Item
  - Jooste, EH, Haft, WA, Ames, WA, Sherman, FS, and Vallejo, MC. "Anesthetic care of parturients with single ventricle physiology." Journal of Clinical Anesthesia 25, no. 5 (2013): 417-423. Full Text
  - Chrysostomou, C, Sanchez-de-Toledo, J, Wearden, P, Jooste, EH, Lichtenstein, SE, Callahan, PM, Suresh, T, O'Malley, E, Shiderly, D, Haney, J, Yoshida, M, Orr, R, Munoz, R, and Morell, VO. "Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations." Ann Thorac Surg 92, no. 3 (September 2011): 964-972. Full Text Link to Item
  - Jooste, EH, Muhly, WT, Ibinson, JW, Suresh, T, Damian, D, Phadke, A, Callahan, P, Miller, S, Feingold, B, Lichtenstein, SE, Cain, JG, Chrysostomou, C, and Davis, PJ. "Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization." Anesth Analg 111, no. 6 (December 2010): 1490-1496. Full Text Link to Item
  - Chrysostomou, C, Lichtenstein, SE, Jooste, EH, Callahan, P, Suresh, T, Beerman, L, Shiderly, D, Omalley, E, Orr, R, Yoshida, M, Wearden, P, Morell, VO, Munoz, R, and Sanchez-de-Toledo, J. "Perioperative Use of the Alpha-2 Adrenergic Agonist Dexmedetomidine, Reduces the Incidence of Supraventricular and Ventricular Tachyarrhythmias in Patients Undergoing Congenital Cardiac Surgery." CIRCULATION 122, no. 21 (November 23, 2010). Link to Item
  - Lazol, JP, Lichtenstein, SE, Jooste, EH, Shiderly, D, Kudchadker, NA, Tatum, GH, Orr, RA, Wearden, PD, Morell, VO, Munoz, RA, and Chrysostomou, C. "Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study." Pediatr Crit Care Med 11, no. 5 (September 2010): 589-592. Full Text Link to Item
  - Tuchman, JB, Concetta Lupa, M, and Jooste, EH. "Emergency airway management of tracheo-innominate fistulas in the pediatric population." Can J Anaesth 57, no. 9 (September 2010): 865-867. (Letter) Full Text Link to Item
  - Chrysostomou, C, Komarlu, R, Lichtenstein, S, Shiderly, D, Arora, G, Orr, R, Wearden, PD, Morell, VO, Munoz, R, and Jooste, EH. "Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease." Intensive Care Med 36, no. 5 (May 2010): 836-842. Full Text Link to Item
  - Bailey, AG, McNaull, PP, Jooste, E, and Tuchman, JB. "Perioperative crystalloid and colloid fluid management in children: where are we and how did we get here?." Anesth Analg 110, no. 2 (February 1, 2010): 375-390. (Review) Full Text Link to Item
  - Manrique, AM, Arroyo, M, Lin, Y, El Khoudary, SR, Colvin, E, Lichtenstein, S, Chrysostomou, C, Orr, R, Jooste, E, Davis, P, Wearden, P, Morell, V, and Munoz, R. "Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study." J Thorac Cardiovasc Surg 139, no. 1 (January 2010): 162-169.e2. Full Text Link to Item
  - Tuchman, JB, Lupa, MC, and Jooste, EH. "Emergency airway management of tracheo-innominate fistulas in the pediatric population." Canadian Journal of Anesthesia (2010): 1-3. Full Text
  - Manrique, A, Jooste, EH, Kuch, BA, Lichtenstein, SE, Morell, V, Munoz, R, Ellis, D, and Davis, PJ. "The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass." Anesth Analg 109, no. 1 (July 2009): 45-52. Full Text Link to Item
  - Jooste, EH, Chalifoux, T, and Broadman, LM. "A perioperative strategy for the placement of a thoracic epidural catheter in a pediatric patient on high-dose enoxaprin." Paediatr Anaesth 17, no. 9 (September 2007): 907-909. (Letter) Full Text Link to Item
  - Jooste, E, Zhang, Y, and Emala, CW. "Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways." Anesthesiology 106, no. 4 (April 2007): 763-772. Full Text Link to Item
  - Jooste, EH, Sharma, A, Zhang, Y, and Emala, CW. "Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor." Anesthesiology 103, no. 6 (December 2005): 1195-1203. Link to Item
  - Jooste, EH, Ohkawa, S, and Sun, LS. "Fiberoptic intubation with dexmedetomidine in two children with spinal cord impingements." Anesth Analg 101, no. 4 (October 2005): 1248-. (Letter) Full Text Link to Item
  - Jooste, E, Zhang, Y, and Emala, CW. "Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle." Anesthesiology 102, no. 1 (January 2005): 117-124. Link to Item
  - Jooste, E, Klafter, F, Hirshman, CA, and Emala, CW. "A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism." Anesthesiology 98, no. 4 (April 2003): 906-911. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Book Sections

Journal Articles