Edmund Hilton Jooste | Scholars@Duke

Edmund Hilton Jooste
Professor of Anesthesiology

Dr Jooste’s initial research focus was in the investigation of the smooth muscle airway effects of various non-depolarizing muscle relaxants. Recently, Dr Jooste has been involved in clinical research, investigating the pharmacokinetics and pharmacodynamics of anesthetic agents in children and in particular the cardiovascular effects of dexmedetomidine. His clinical practice focuses on the anesthesia care of children with congenital cardiac disease.

Current Appointments & Affiliations

Professor of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2019
Associate Professor in Pediatrics, Pediatrics, Clinical Science Departments 2012

Contact Information

edmund.jooste@duke.edu

Background
Education, Training, & Certifications
- M.B.B.S., University of Pretoria (South Africa) 1995
Duke Appointment History
- Associate Professor of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2011 - 2019
- Instructor Temporary in the Department of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2011
Research
Selected Grants
- ATIII Coagulation System in Infants-Investigator Led Study Agreement awarded by Grifols USA, LLC 2014 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Jooste, EH, Scholl, R, Wu, Y-H, Jaquiss, RDB, Lodge, AJ, Ames, WA, Homi, HM, Machovec, KA, Greene, NH, Donahue, BS, Shah, N, and Benkwitz, C. "Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery." Journal of Cardiothoracic and Vascular Anesthesia 33, no. 2 (February 2019): 396-402. Full Text
  - Machovec, KA, and Jooste, EH. "Pediatric Transfusion Algorithms: Coming to a Cardiac Operating Room Near You." Journal of Cardiothoracic and Vascular Anesthesia (December 5, 2018). (Review) Full Text
  - Kamyszek, RW, Leraas, HJ, Nag, UP, Olivere, LA, Nash, AL, Kemeny, HR, Kim, J, Hill, KD, Fleming, GA, Jooste, EH, Otto, J, and Tracy, ET. "Routine postprocedure ultrasound increases rate of detection of femoral arterial thrombosis in infants after cardiac catheterization." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions (November 23, 2018). Full Text
  - Greene, NH, Jooste, EH, Thibault, DP, Wallace, AS, Wang, A, Vener, DF, Matsouaka, RA, Jacobs, ML, Jacobs, JP, Hill, KD, and Ames, WA. "A Study of Practice Behavior for Endotracheal Intubation Site for Children With Congenital Heart Disease Undergoing Surgery: Impact of Endotracheal Intubation Site on Perioperative Outcomes-An Analysis of the Society of Thoracic Surgeons Congenital Cardiac Anesthesia Society Database." Anesthesia and Analgesia (September 5, 2018). Full Text Open Access Copy
  - Jooste, EH, and Machovec, KA. "Hypercoagulability - The Underdiagnosed and Undertreated Nemesis of Congenital Heart Surgery." Journal of Cardiothoracic and Vascular Anesthesia 32, no. 4 (August 2018): 1664-1666. Full Text
  - Al-Subu, A, Jooste, E, Hornik, CP, Fleming, GA, Cheifetz, IM, and Ofori-Amanfo, G. "Correlation between minute carbon dioxide elimination and pulmonary blood flow in single-ventricle patients after stage 1 palliation and 2-ventricle patients with intracardiac shunts: A pilot study." Paediatric Anaesthesia 28, no. 7 (July 2018): 618-624. Full Text
  - Einhorn, LM, Taicher, BM, Greene, NH, Reinstein, LJ, Jooste, EH, Campbell, MJ, and Machovec, KA. "Percutaneous endoscopic gastrostomy vs surgical gastrostomy in infants with congenital heart disease." Paediatric Anaesthesia 28, no. 7 (July 2018): 612-617. Full Text
  - Van Driest, SL, Jooste, EH, Shi, Y, Choi, L, Darghosian, L, Hill, KD, Smith, AH, Kannankeril, PJ, Roden, DM, and Ware, LB. "Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery." Jama Pediatrics 172, no. 7 (July 2018): 655-663. Full Text
  - Jooste, EH, and Machovec, KA. "It is Time to Stop Missing the Forest for the Trees: The Debate on Corticosteroid Use in Pediatric Heart Surgery." Journal of cardiothoracic and vascular anesthesia 31, no. 6 (December 2017): 1957-1959. Full Text
  - Alberts, M, Groom, RC, Walczak, R, Kramer, R, Karpiel, A, Dieter, J, Sheth, L, Greene, NH, and Jooste, EH. "In Vitro Evaluation of the Fresenius Kabi CATSmart Autotransfusion System." The Journal of Extra Corporeal Technology 49, no. 2 (June 2017): 107-111.
  - Tew, S, Fontes, ML, Greene, NH, Kertai, MD, Ofori-Amanfo, G, Jaquiss, RDB, Lodge, AJ, Ames, WA, Homi, HM, Machovec, KA, and Jooste, EH. "Natural history of nonimmune-mediated thrombocytopenia and acute kidney injury in pediatric open-heart surgery." Paediatric Anaesthesia 27, no. 3 (March 2017): 305-313. Full Text
  - Jooste, EH, Hammer, GB, Reyes, CR, Katkade, V, and Szmuk, P. "Phase IV, Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Patients Undergoing Procedure-Type Sedation." Frontiers in Pharmacology 8 (January 2017): 529-null. Full Text
  - Jooste, EH, Machovec, KA, Einhorn, LM, Ames, WA, Homi, HM, Jaquiss, RDB, Lodge, AJ, Levy, JH, and Welsby, IJ. "3-Factor Prothrombin Complex Concentrates in Infants With Refractory Bleeding After Cardiac Surgery." Journal of cardiothoracic and vascular anesthesia 30, no. 6 (December 2016): 1627-1631. Full Text
  - Amhaz, HH, Buretta, K, Jooste, EH, Machovec, K, Marcus, JR, and Ames, WA. "Upper Extremity Peripheral Intravenous Line Infiltration With Concomitant Loss of Pulses Treated With Lipoaspiration: A Case Report." A & A case reports 7, no. 9 (November 2016): 185-187. Full Text
  - Machovec, KA, Smigla, G, Ames, WA, Schwimer, C, Homi, HM, Dhakal, IB, Jaquiss, RDB, Lodge, AJ, and Jooste, EH. "Reduction in blood transfusion in a cohort of infants having cardiac surgery with cardiopulmonary bypass after instituting a goal-directed transfusion policy." Perfusion 31, no. 7 (October 2016): 598-603. Full Text
  - Kertai, MD, Zhou, S, Karhausen, JA, Cooter, M, Jooste, E, Li, Y-J, White, WD, Aronson, S, Podgoreanu, MV, Gaca, J, Welsby, IJ, Levy, JH, Stafford-Smith, M, Mathew, JP, and Fontes, ML. "In Reply." Anesthesiology 125, no. 2 (August 2016): 438-439. (Letter) Full Text
  - Machovec, KA, Jaquiss, RDB, Kaemmer, DD, Ames, WA, Homi, HM, Walczak, RJ, Lodge, AJ, and Jooste, EH. "Cardiopulmonary Bypass Strategy for a Cyanotic Child With Hemoglobin SC Disease." The Annals of thoracic surgery 101, no. 6 (June 2016): 2373-2375. Full Text
  - Kertai, MD, Zhou, S, Karhausen, JA, Cooter, M, Jooste, E, Li, Y-J, White, WD, Aronson, S, Podgoreanu, MV, Gaca, J, Welsby, IJ, Levy, JH, Stafford-Smith, M, Mathew, JP, and Fontes, ML. "Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery." Anesthesiology 124, no. 2 (February 2016): 339-352. Full Text Open Access Copy
  - McCartney, SL, Machovec, K, and Jooste, EH. "Uncorrected Tetralogy of Fallot, Biventricular Dysfunction, and a Large Pericardial Effusion." Journal of cardiothoracic and vascular anesthesia 29, no. 5 (October 2015): 1391-1395. Full Text Open Access Copy
  - Machovec, KA, Jooste, EH, Walczak, RJ, Homi, HM, Jaquiss, RDB, Lodge, AJ, and Ames, WA. "A change in anticoagulation monitoring improves safety, reduces transfusion, and reduces costs in infants on cardiopulmonary bypass." Paediatric anaesthesia 25, no. 6 (June 2015): 580-586. Full Text
  - Machovec, KA, Jooste, EH, and Ames, WA. "Ventricular pacing for induced hypotension in a toddler." A & A case reports 3, no. 3 (August 2014): 38-39. Full Text
  - Yang, CI, Fine, GF, Jooste, EH, Mutich, R, Walczak, SA, and Motoyama, EK. "The effect of cisatracurium and rocuronium on lung function in anesthetized children." Anesthesia and Analgesia 117, no. 6 (December 2013): 1393-1400. Full Text
  - Jooste, EH, Haft, WA, Ames, WA, Sherman, FS, and Vallejo, MC. "Anesthetic care of parturients with single ventricle physiology." J Clin Anesth 25, no. 5 (August 2013): 417-423. (Review) Full Text Link to Item
  - Chrysostomou, C, Morell, VO, Wearden, P, Sanchez-de-Toledo, J, Jooste, EH, and Beerman, L. "Dexmedetomidine: therapeutic use for the termination of reentrant supraventricular tachycardia." Congenit Heart Dis 8, no. 1 (January 2013): 48-56. Full Text Link to Item
  - Jooste, EH, Haft, WA, Ames, WA, Sherman, FS, and Vallejo, MC. "Anesthetic care of parturients with single ventricle physiology." Journal of Clinical Anesthesia 25, no. 5 (2013): 417-423. Full Text
  - Chrysostomou, C, Sanchez-de-Toledo, J, Wearden, P, Jooste, EH, Lichtenstein, SE, Callahan, PM, Suresh, T, O'Malley, E, Shiderly, D, Haney, J, Yoshida, M, Orr, R, Munoz, R, and Morell, VO. "Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations." The Annals of Thoracic Surgery 92, no. 3 (September 2011): 964-972. Full Text
  - Jooste, EH, Muhly, WT, Ibinson, JW, Suresh, T, Damian, D, Phadke, A, Callahan, P, Miller, S, Feingold, B, Lichtenstein, SE, Cain, JG, Chrysostomou, C, and Davis, PJ. "Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization." Anesthesia and Analgesia 111, no. 6 (December 2010): 1490-1496. Full Text
  - Chrysostomou, C, Lichtenstein, SE, Jooste, EH, Callahan, P, Suresh, T, Beerman, L, Shiderly, D, Omalley, E, Orr, R, Yoshida, M, Wearden, P, Morell, VO, Munoz, R, and Sanchez-de-Toledo, J. "Perioperative Use of the Alpha-2 Adrenergic Agonist Dexmedetomidine, Reduces the Incidence of Supraventricular and Ventricular Tachyarrhythmias in Patients Undergoing Congenital Cardiac Surgery." CIRCULATION 122, no. 21 (November 23, 2010). Link to Item
  - Lazol, JP, Lichtenstein, SE, Jooste, EH, Shiderly, D, Kudchadker, NA, Tatum, GH, Orr, RA, Wearden, PD, Morell, VO, Munoz, RA, and Chrysostomou, C. "Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study." Pediatr Crit Care Med 11, no. 5 (September 2010): 589-592. Full Text Link to Item
  - Tuchman, JB, Concetta Lupa, M, and Jooste, EH. "Emergency airway management of tracheo-innominate fistulas in the pediatric population." Can J Anaesth 57, no. 9 (September 2010): 865-867. (Letter) Full Text Link to Item
  - Chrysostomou, C, Komarlu, R, Lichtenstein, S, Shiderly, D, Arora, G, Orr, R, Wearden, PD, Morell, VO, Munoz, R, and Jooste, EH. "Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease." Intensive Care Medicine 36, no. 5 (May 2010): 836-842. Full Text
  - Bailey, AG, McNaull, PP, Jooste, E, and Tuchman, JB. "Perioperative crystalloid and colloid fluid management in children: where are we and how did we get here?." Anesthesia and Analgesia 110, no. 2 (February 2010): 375-390. (Review) Full Text
  - Manrique, AM, Arroyo, M, Lin, Y, El Khoudary, SR, Colvin, E, Lichtenstein, S, Chrysostomou, C, Orr, R, Jooste, E, Davis, P, Wearden, P, Morell, V, and Munoz, R. "Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study." J Thorac Cardiovasc Surg 139, no. 1 (January 2010): 162-169.e2. Full Text Link to Item
  - Tuchman, JB, Lupa, MC, and Jooste, EH. "Emergency airway management of tracheo-innominate fistulas in the pediatric population." Canadian Journal of Anesthesia (2010): 1-3. Full Text
  - Manrique, A, Jooste, EH, Kuch, BA, Lichtenstein, SE, Morell, V, Munoz, R, Ellis, D, and Davis, PJ. "The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass." Anesth Analg 109, no. 1 (July 2009): 45-52. Full Text Link to Item
  - Jooste, EH, Chalifoux, T, and Broadman, LM. "A perioperative strategy for the placement of a thoracic epidural catheter in a pediatric patient on high-dose enoxaprin." Paediatr Anaesth 17, no. 9 (September 2007): 907-909. (Letter) Full Text Link to Item
  - Jooste, E, Zhang, Y, and Emala, CW. "Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways." Anesthesiology 106, no. 4 (April 2007): 763-772. Full Text
  - Jooste, EH, Sharma, A, Zhang, Y, and Emala, CW. "Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor." Anesthesiology 103, no. 6 (December 2005): 1195-1203. Full Text
  - Jooste, EH, Ohkawa, S, and Sun, LS. "Fiberoptic intubation with dexmedetomidine in two children with spinal cord impingements." Anesth Analg 101, no. 4 (October 2005): 1248-. (Letter) Full Text Link to Item
  - Jooste, E, Zhang, Y, and Emala, CW. "Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle." Anesthesiology 102, no. 1 (January 2005): 117-124. Link to Item
  - Jooste, E, Klafter, F, Hirshman, CA, and Emala, CW. "A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism." Anesthesiology 98, no. 4 (April 2003): 906-911. Link to Item
- Book Sections
  - Ames, W, Hill, K, and Jooste, EH. "Anesthesia in the cardiac catheterization laboratory and MRI." In Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care, 721-741. January 1, 2014. Full Text
- Conference Papers
  - Darghosian, L, Shi, Y, Choi, L, Smith, AH, Jooste, EH, Hill, KD, Kannankeril, PJ, Ware, LB, and Van Driest, SL. "Postoperative Acetaminophen Dose is Associated With Lower Rate of Acute Kidney Injury After Cardiac Surgery and Cardiopulmonary Bypass." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers