Edmund Hilton Jooste | Scholars@Duke

Edmund Hilton Jooste
Professor of Anesthesiology

Dr Jooste’s initial research focus was in the investigation of the smooth muscle airway effects of various non-depolarizing muscle relaxants. Recently, Dr Jooste has been involved in clinical research, investigating the pharmacokinetics and pharmacodynamics of anesthetic agents in children and in particular the cardiovascular effects of dexmedetomidine. His clinical practice focuses on the anesthesia care of children with congenital cardiac disease.

Current Appointments & Affiliations

Professor of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2021
Professor in Pediatrics, Pediatrics, Clinical Science Departments 2020

Contact Information

edmund.jooste@duke.edu

Background
Education, Training, & Certifications
- M.B.B.S., University of Pretoria (South Africa) 1995
Previous Appointments & Affiliations
- Professor of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2019 - 2020
- Professor in Pediatrics, Pediatrics, Clinical Science Departments 2019 - 2020
- Associate Professor of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2011 - 2019
- Associate Professor in Pediatrics, Pediatrics, Clinical Science Departments 2012 - 2019
- Instructor Temporary in the Department of Anesthesiology, Anesthesiology, Pediatrics, Anesthesiology 2011
Research
Selected Grants
- Turek - Step 2 Project awarded by Enzyvant 2022 - 2024
- Pain Control with Regional Anesthesia following Pediatric Cardiac Surgery: A Randomized Double-Blinded Pilot Study awarded by Society for Pediatric Anesthesia 2023
- Enzyvant Monkey Study awarded by Enzyvant 2019 - 2022
- A PHASE 3/4 RANDOMIZED, DOUBLE-BLIND, DOSE-RANGING STUDY OF THE SAFETY AND EFFICACY OF DEXMEDETOMIDINE (DEX) USED WITH PROPOFOL (PRO) AS NEEDED FOR PROCEDURAL SEDATION OF PEDIATRIC SUBJECTS ¿1 MONTH TO <17 YEARS OF AGE UNDERGOING MRI SCANS awarded by Pfizer, Inc. 2020 - 2022
- ATIII Coagulation System in Infants-Investigator Led Study Agreement awarded by Grifols USA, LLC 2014 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Finucane, Elizabeth, Edmund Jooste, and Kelly A. Machovec. “Neuromonitoring Modalities in Pediatric Cardiac Anesthesia: A Review of the Literature.” J Cardiothorac Vasc Anesth 34, no. 12 (December 2020): 3420–28. https://doi.org/10.1053/j.jvca.2020.02.054.
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  - Barnett, Annika M., Kelly A. Machovec, Warwick A. Ames, Hercilia M. Homi, Jennifer L. Turi, Jeannie Koo, Matthew Fuller, and Edmund H. Jooste. “The effect of intraoperative methadone during pediatric cardiac surgery on postoperative opioid requirements.” Paediatr Anaesth 30, no. 7 (July 2020): 773–79. https://doi.org/10.1111/pan.13903.
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  - Greene, Nathaniel H., Edmund H. Jooste, Dylan P. Thibault, Amelia S. Wallace, Alice Wang, David F. Vener, Roland A. Matsouaka, et al. “A Study of Practice Behavior for Endotracheal Intubation Site for Children With Congenital Heart Disease Undergoing Surgery: Impact of Endotracheal Intubation Site on Perioperative Outcomes-An Analysis of the Society of Thoracic Surgeons Congenital Cardiac Anesthesia Society Database.” Anesth Analg 129, no. 4 (October 2019): 1061–68. https://doi.org/10.1213/ANE.0000000000003594.
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  - Machovec, Kelly A., and Edmund H. Jooste. “The Database Dilemma: An Imperfect but Critical Tool to Improve Quality and Benchmark Outcomes.” J Cardiothorac Vasc Anesth 33, no. 10 (October 2019): 2615–17. https://doi.org/10.1053/j.jvca.2019.03.065.
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  - Machovec, Kelly A., and Edmund H. Jooste. “Pediatric Transfusion Algorithms: Coming to a Cardiac Operating Room Near You.” J Cardiothorac Vasc Anesth 33, no. 7 (July 2019): 2017–29. https://doi.org/10.1053/j.jvca.2018.12.008.
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  - Jones, Stephanie E., Edmund H. Jooste, Erin A. Gottlieb, Jamie Schwartz, Dheeraj Goswami, Nischal K. Gautam, Claudia Benkwitz, et al. “Preoperative Laboratory Studies for Pediatric Cardiac Surgery Patients: A Multi-Institutional Perspective.” Anesth Analg 128, no. 5 (May 2019): 1051–54. https://doi.org/10.1213/ANE.0000000000004114.
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  - Kamyszek, Reed W., Harold J. Leraas, Uttara P. Nag, Lindsey A. Olivere, Amanda L. Nash, Hanna R. Kemeny, Jina Kim, et al. “Routine postprocedure ultrasound increases rate of detection of femoral arterial thrombosis in infants after cardiac catheterization.” Catheter Cardiovasc Interv 93, no. 4 (March 1, 2019): 652–59. https://doi.org/10.1002/ccd.28009.
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  - Jooste, Edmund H., Rebecca Scholl, Yi-Hung Wu, Robert D. B. Jaquiss, Andrew J. Lodge, Warwick A. Ames, H Mayumi Homi, et al. “Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery.” J Cardiothorac Vasc Anesth 33, no. 2 (February 2019): 396–402. https://doi.org/10.1053/j.jvca.2018.05.052.
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  - Jooste, Edmund H., and Kelly A. Machovec. “Hypercoagulability - The Underdiagnosed and Undertreated Nemesis of Congenital Heart Surgery.” J Cardiothorac Vasc Anesth 32, no. 4 (August 2018): 1664–66. https://doi.org/10.1053/j.jvca.2018.01.016.
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  - Al-Subu, Awni, Edmund Jooste, Christoph P. Hornik, Gregory A. Fleming, Ira M. Cheifetz, and George Ofori-Amanfo. “Correlation between minute carbon dioxide elimination and pulmonary blood flow in single-ventricle patients after stage 1 palliation and 2-ventricle patients with intracardiac shunts: A pilot study.” Paediatr Anaesth 28, no. 7 (July 2018): 618–24. https://doi.org/10.1111/pan.13423.
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  - Einhorn, Lisa M., Brad M. Taicher, Nathaniel H. Greene, Leon J. Reinstein, Edmund H. Jooste, Michael J. Campbell, and Kelly A. Machovec. “Percutaneous endoscopic gastrostomy vs surgical gastrostomy in infants with congenital heart disease.” Paediatr Anaesth 28, no. 7 (July 2018): 612–17. https://doi.org/10.1111/pan.13416.
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  - Van Driest, Sara L., Edmund H. Jooste, Yaping Shi, Leena Choi, Leon Darghosian, Kevin D. Hill, Andrew H. Smith, Prince J. Kannankeril, Dan M. Roden, and Lorraine B. Ware. “Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery.” Jama Pediatr 172, no. 7 (July 1, 2018): 655–63. https://doi.org/10.1001/jamapediatrics.2018.0614.
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  - Jooste, Edmund H., and Kelly A. Machovec. “It is Time to Stop Missing the Forest for the Trees: The Debate on Corticosteroid Use in Pediatric Heart Surgery.” J Cardiothorac Vasc Anesth 31, no. 6 (December 2017): 1957–59. https://doi.org/10.1053/j.jvca.2017.06.035.
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  - Alberts, Melissa, Robert C. Groom, Richard Walczak, Robert Kramer, Adrienne Karpiel, Jeanette Dieter, Lisa Sheth, Nathaniel H. Greene, and Edmund H. Jooste. “In Vitro Evaluation of the Fresenius Kabi CATSmart Autotransfusion System.” J Extra Corpor Technol 49, no. 2 (June 2017): 107–11.
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  - Tew, Shannon, Manuel L. Fontes, Nathaniel H. Greene, Miklos D. Kertai, George Ofori-Amanfo, Robert D. B. Jaquiss, Andrew J. Lodge, et al. “Natural history of nonimmune-mediated thrombocytopenia and acute kidney injury in pediatric open-heart surgery.” Paediatr Anaesth 27, no. 3 (March 2017): 305–13. https://doi.org/10.1111/pan.13063.
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  - Jooste, Edmund H., Gregory B. Hammer, Christian R. Reyes, Vaibhav Katkade, and Peter Szmuk. “Phase IV, Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Patients Undergoing Procedure-Type Sedation.” Front Pharmacol 8 (2017): 529. https://doi.org/10.3389/fphar.2017.00529.
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  - Jooste, Edmund H., Kelly A. Machovec, Lisa M. Einhorn, Warwick A. Ames, Hercilia M. Homi, Robert D. B. Jaquiss, Andrew J. Lodge, Jerrold H. Levy, and Ian J. Welsby. “3-Factor Prothrombin Complex Concentrates in Infants With Refractory Bleeding After Cardiac Surgery.” J Cardiothorac Vasc Anesth 30, no. 6 (December 2016): 1627–31. https://doi.org/10.1053/j.jvca.2016.01.029.
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  - Amhaz, Hassan H., Kate Buretta, Edmund H. Jooste, Kelly Machovec, Jeffery R. Marcus, and Warwick A. Ames. “Upper Extremity Peripheral Intravenous Line Infiltration With Concomitant Loss of Pulses Treated With Lipoaspiration: A Case Report.” A a Case Rep 7, no. 9 (November 1, 2016): 185–87. https://doi.org/10.1213/XAA.0000000000000381.
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  - Machovec, Kelly A., Gregory Smigla, Warwick A. Ames, Courtney Schwimer, H Mayumi Homi, Ishwori B. Dhakal, Robert D. B. Jaquiss, Andrew J. Lodge, and Edmund H. Jooste. “Reduction in blood transfusion in a cohort of infants having cardiac surgery with cardiopulmonary bypass after instituting a goal-directed transfusion policy.” Perfusion 31, no. 7 (October 2016): 598–603. https://doi.org/10.1177/0267659116640866.
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  - Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “In Reply.” Anesthesiology 125, no. 2 (August 2016): 438–39. https://doi.org/10.1097/ALN.0000000000001190.
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  - Machovec, Kelly A., Robert D. B. Jaquiss, David D. Kaemmer, Warwick A. Ames, Hercilia M. Homi, Richard J. Walczak, Andrew J. Lodge, and Edmund H. Jooste. “Cardiopulmonary Bypass Strategy for a Cyanotic Child With Hemoglobin SC Disease.” Ann Thorac Surg 101, no. 6 (June 2016): 2373–75. https://doi.org/10.1016/j.athoracsur.2015.09.046.
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  - Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.” Anesthesiology 124, no. 2 (February 2016): 339–52. https://doi.org/10.1097/ALN.0000000000000959.
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  - McCartney, Sharon L., Kelly Machovec, and Edmund H. Jooste. “Uncorrected Tetralogy of Fallot, Biventricular Dysfunction, and a Large Pericardial Effusion.” J Cardiothorac Vasc Anesth 29, no. 5 (October 2015): 1391–95. https://doi.org/10.1053/j.jvca.2015.06.033.
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  - Machovec, Kelly A., Edmund H. Jooste, Richard J. Walczak, Hercilia Mayumi Homi, Robert D. B. Jaquiss, Andrew J. Lodge, and Warwick A. Ames. “A change in anticoagulation monitoring improves safety, reduces transfusion, and reduces costs in infants on cardiopulmonary bypass.” Paediatr Anaesth 25, no. 6 (June 2015): 580–86. https://doi.org/10.1111/pan.12591.
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  - Machovec, Kelly A., Edmund H. Jooste, and Warwick A. Ames. “Ventricular pacing for induced hypotension in a toddler.” A a Case Rep 3, no. 3 (August 1, 2014): 38–39. https://doi.org/10.1213/XAA.0000000000000045.
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  - Yang, Charles I., Gavin F. Fine, Edmund H. Jooste, Rebecca Mutich, Stephen A. Walczak, and Etsuro K. Motoyama. “The effect of cisatracurium and rocuronium on lung function in anesthetized children.” Anesth Analg 117, no. 6 (December 2013): 1393–1400. https://doi.org/10.1213/ANE.0b013e3182a6d191.
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  - Jooste, Edmund H., Wendy A. Haft, Warwick A. Ames, Frederick S. Sherman, and Manuel C. Vallejo. “Anesthetic care of parturients with single ventricle physiology.” J Clin Anesth 25, no. 5 (August 2013): 417–23. https://doi.org/10.1016/j.jclinane.2012.08.003.
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  - Chrysostomou, Constantinos, Victor O. Morell, Peter Wearden, Joan Sanchez-de-Toledo, Edmund H. Jooste, and Lee Beerman. “Dexmedetomidine: therapeutic use for the termination of reentrant supraventricular tachycardia.” Congenit Heart Dis 8, no. 1 (2013): 48–56. https://doi.org/10.1111/j.1747-0803.2012.00669.x.
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  - Chrysostomou, Constantinos, Joan Sanchez-de-Toledo, Peter Wearden, Edmund H. Jooste, Steven E. Lichtenstein, Patrick M. Callahan, Tunga Suresh, et al. “Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations.” Ann Thorac Surg 92, no. 3 (September 2011): 964–72. https://doi.org/10.1016/j.athoracsur.2011.04.099.
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  - Jooste, E. H., W. T. Muhly, J. W. Ibinson, T. Suresh, D. Damian, A. Phadke, P. Callahan, et al. “Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization.” Anesth Analg 111, no. 6 (December 2010): 1490–96. https://doi.org/10.1213/ANE.0b013e3181f7e2ab.
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  - Chrysostomou, Constantinos, Steven E. Lichtenstein, Edmund H. Jooste, Patrick Callahan, Tunga Suresh, Lee Beerman, Dana Shiderly, et al. “Perioperative Use of the Alpha-2 Adrenergic Agonist Dexmedetomidine, Reduces the Incidence of Supraventricular and Ventricular Tachyarrhythmias in Patients Undergoing Congenital Cardiac Surgery.” Circulation 122, no. 21 (November 23, 2010).
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  - Lazol, Judith P., Steven E. Lichtenstein, Edmund H. Jooste, Dana Shiderly, Nivedit A. Kudchadker, Gregory H. Tatum, Richard A. Orr, et al. “Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study.” Pediatr Crit Care Med 11, no. 5 (September 2010): 589–92. https://doi.org/10.1097/PCC.0b013e3181ceae7d.
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  - Tuchman, Jay B., M. Concetta Lupa, and Edmund H. Jooste. “Emergency airway management of tracheo-innominate fistulas in the pediatric population.” Can J Anaesth 57, no. 9 (September 2010): 865–67. https://doi.org/10.1007/s12630-010-9342-0.
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  - Chrysostomou, Constantinos, Rukmini Komarlu, Steven Lichtenstein, Dana Shiderly, Gaurav Arora, Richard Orr, Peter D. Wearden, Victor O. Morell, Ricardo Munoz, and Edmund H. Jooste. “Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease.” Intensive Care Med 36, no. 5 (May 2010): 836–42. https://doi.org/10.1007/s00134-010-1782-z.
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  - Bailey, Ann G., Peggy P. McNaull, Edmund Jooste, and Jay B. Tuchman. “Perioperative crystalloid and colloid fluid management in children: where are we and how did we get here?” Anesth Analg 110, no. 2 (February 1, 2010): 375–90. https://doi.org/10.1213/ANE.0b013e3181b6b3b5.
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  - Manrique, Ana M., Margarita Arroyo, Yan Lin, Samar R. El Khoudary, Erin Colvin, Steven Lichtenstein, Constantinos Chrysostomou, et al. “Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study.” J Thorac Cardiovasc Surg 139, no. 1 (January 2010): 162-169.e2. https://doi.org/10.1016/j.jtcvs.2009.07.064.
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  - Tuchman, J. B., M. Concetta Lupa, and E. H. Jooste. “Emergency airway management of tracheo-innominate fistulas in the pediatric population.” Canadian Journal of Anesthesia, 2010, 1–3.
  - Manrique, Ana, Edmund H. Jooste, Bradley A. Kuch, Steven E. Lichtenstein, Victor Morell, Ricardo Munoz, Demetrius Ellis, and Peter J. Davis. “The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass.” Anesth Analg 109, no. 1 (July 2009): 45–52. https://doi.org/10.1213/ane.0b013e3181a7f00a.
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  - Jooste, Edmund H., Thomas Chalifoux, and Lynn M. Broadman. “A perioperative strategy for the placement of a thoracic epidural catheter in a pediatric patient on high-dose enoxaprin.” Paediatr Anaesth 17, no. 9 (September 2007): 907–9. https://doi.org/10.1111/j.1460-9592.2007.02290.x.
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  - Jooste, Edmund, Yi Zhang, and Charles W. Emala. “Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways.” Anesthesiology 106, no. 4 (April 2007): 763–72. https://doi.org/10.1097/01.anes.0000264763.48920.c9.
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  - Jooste, Edmund H., Amit Sharma, Yi Zhang, and Charles W. Emala. “Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor.” Anesthesiology 103, no. 6 (December 2005): 1195–1203. https://doi.org/10.1097/00000542-200512000-00014.
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  - Jooste, Edmund H., Susumu Ohkawa, and Lena S. Sun. “Fiberoptic intubation with dexmedetomidine in two children with spinal cord impingements.” Anesth Analg 101, no. 4 (October 2005): 1248. https://doi.org/10.1213/01.ANE.0000173765.94392.80.
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  - Jooste, Edmund, Yi Zhang, and Charles W. Emala. “Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle.” Anesthesiology 102, no. 1 (January 2005): 117–24. https://doi.org/10.1097/00000542-200501000-00020.
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  - Jooste, Edmund, Farrah Klafter, Carol A. Hirshman, and Charles W. Emala. “A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism.” Anesthesiology 98, no. 4 (April 2003): 906–11. https://doi.org/10.1097/00000542-200304000-00017.
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- Book Sections
  - Ames, W., K. Hill, and E. H. Jooste. “Anesthesia in the cardiac catheterization laboratory and MRI.” In Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care, 721–41, 2014. https://doi.org/10.1007/978-1-4471-4619-3_147.
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- Conference Papers
  - Darghosian, Leon, Yaping Shi, Leena Choi, Andrew H. Smith, Edmund H. Jooste, Kevin D. Hill, Prince J. Kannankeril, Lorraine B. Ware, and Sara L. Van Driest. “Postoperative Acetaminophen Dose is Associated With Lower Rate of Acute Kidney Injury After Cardiac Surgery and Cardiopulmonary Bypass.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers