Research Interests
Dr. Samei’s scientific expertise include x-ray imaging, theoretical imaging models, simulation methods, and experimental techniques in medical image formation, quantification, and perception. His research aims to bridge the gap between scientific scholarship and clinical practice, in the meaningful realization of translational research, and in clinical processes that are informed by scientific evidence. He has advanced image quality and safety metrics and radiometrics that are clinically relevant and that can be used to design, optimize, and monitor interpretive and quantitative performance of imaging techniques. These have been implemented in advanced imaging performance characterization, procedural optimization, and clinical dose and quality analytics. His most recent research interests have been virtual clinical trial across a broad spectrum of oncologic, pulmonary, cardiac, and vascular diseases, and developing methodological advances that provide smart fusions of principle-informed and AI-based, data-informed approaches to scientific inquiry.
Selected Grants
Research Triangle Center of Excellence in Regulatory Science and Innovation
ResearchCo-Principal Investigator · Awarded by University of North Carolina - Chapel Hill · 2023 - 2028Accuracy and Precision in CT Quantification of COPD Through Virtual Imaging Trials
ResearchInvestigator · Awarded by National Heart, Lung, and Blood Institute · 2021 - 2026Personalized Digital Twin for Precise Lung Stereotactic Body Radiation Therapy (SBRT) Driven by Fractional 4D Volumetric Imaging
ResearchPrincipal Investigator · Awarded by Emory University · 2024 - 2026Center for Virtual Imaging Trials
ResearchPrincipal Investigator · Awarded by National Institute of Biomedical Imaging and Bioengineering · 2021 - 2025Quality and Safety Monitoring of Clinical Computed Tomography Practice
ResearchPrincipal Investigator · Awarded by Metis · 2021 - 2025Simulation Tools for 3D and 4D CT and Dosimetry
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2007 - 2025Photon Counting Computed Tomography for Detection of Small Liver Metastases: Comparison to Conventional and Dual-Energy Systems
ResearchCo Investigator · Awarded by Society of Abdominal Radiology · 2022 - 2024Prospective Comparison of Low Dose Computed Tomography to Conventional Dose Computed Tomography for the Evaluation of Glenoid Anatomy in Shoulder Arthroplasty
ResearchInvestigator · Awarded by Piedmont Orthopedic Foundation · 2022 - 2023Precision Cardiac CT: Development of a Computational Platform for Optimizing Imaging
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2023Enabling accurate identification and quantification of brown adipose tissue mass by xenon enhanced computed tomography
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2020 - 2022Open-access X-ray and CT simulation toolkit for research in cancer imaging and dosimetry
ResearchCo Investigator · Awarded by GE Global Research · 2019 - 2021Advanced Spectral CT System Design Through Virtual Imaging
ResearchPrincipal Investigator · Awarded by GE Healthcare · 2020 - 20213D Printing of Anatomically Realistic Phantoms for Optimization of Imaging Algorithms
ResearchInvestigator · Awarded by National Institutes of Health · 2018 - 2021Design for systematic consistency of quality and dose in contrast enhanced CT
ResearchPrincipal Investigator · Awarded by Bracco Diagnostics, Inc. · 2018 - 2020Physics Associates Affiliate Residency Program
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Physics Associates · 2017 - 2020Training in Medical Imaging
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2020Imaging Physics Residency Grant
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by American Association of Physicists in Medicine · 2014 - 2018Reconstruction Software Evaluation
ResearchPrincipal Investigator · Awarded by Siemens Medical Solutions USA, Inc. · 2014 - 2018Methodology and Reference Image set for Volumetric Characterization and Compliance
ResearchPrincipal Investigator · Awarded by Radiological Society of North America · 2014 - 2017Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization
ResearchPrincipal Investigator · Awarded by Radiological Society of North America · 2014 - 2017Advancement and Effective Implementation of Dose and Risk Monitoring Systems
ResearchPrincipal Investigator · Awarded by GE Healthcare · 2014 - 2017Decreased Variability for Robust Imaging-based Quantification of Tumor Heterogeneity
ResearchAdvisor · Awarded by Radiological Society of North America · 2015 - 2017IAEA scientific visit and training
ConferencePrincipal Investigator · Awarded by International Atomic Energy Agency · 2016 - 2016Duke Clinical Imaging Physics Group Fellowship
FellowshipPrincipal Investigator · Awarded by Bracco Foundation · 2015 - 2016A Diagnostic Capability Concurrence study of a SSXI Mobile Fluoroscopy System and the OEC 9900 Elite Mobile Fluoroscopy
Clinical TrialInvestigator · Awarded by General Electric Corporation · 2013 - 2016X-Ray Scatter and Phase Imaging for Explosive Detection
ResearchCo-Principal Investigator · Awarded by US Department of Homeland Security · 2011 - 20153D Digital Breast Phantoms For Multimodality Research
ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2014Cross-disciplinary Training in Medical Physics
Inst. Training Prgm or CMEDirector · Awarded by National Institutes of Health · 2007 - 2013Information-Theoretic Based CAD in Mammography
ResearchScientist · Awarded by National Institutes of Health · 2003 - 2011Tomosynthesis for Improved Breast Cancer Detection
ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2011Bi-Plane Correlation Imaging for Early Detection of Lung Cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2010Task-Specific Optimization of Mammographic Systems
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2004 - 2007Resolution Requirements for Mammographic Displays
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2006Early Detection of Lung Cancer via Bi-plane Correlation Chest Imaging
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2004External Relationships
- 12 Sigmas Medical Imaging
- GE Healthcare
- Gammex / Sun Nuclear
- Imalogix, LLC
- METIS Health Analytics, LLC
- Siemens Medical Solutions
- Silomedics, LLC
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.