Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Pediatric Nephrology, University of California - Los Angeles 2004 - 2007
  • Residency: Children's Hospital, Los Angeles, Children's Hospital 2002 - 2004
  • Internship: Children's Hospital, Los Angeles, Children's Hospital 2001 - 2002
  • M.D., Oregon Health and Science University 2001
• 

  Previous Appointments & Affiliations

  • Associate Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2016 - 2020
  • Associate Professor in the Department of Surgery, Surgery, Abdominal Transplant Surgery, Surgery 2018 - 2020
• 

  Leadership & Clinical Positions at Duke

  • Pediatric Kidney Transplant Medical Director
• Research
• 

  Selected Grants

  • Defining the Landscape of HLA Risk Alleles in Primary Nephrotic Syndrome and Post Kidney Transplant Recurrence awarded by National Institutes of Health 2020 - 2025
  • Advancing Transplantation Outcomes in Children - Mechnistic awarded by Boston Children's Hospital 2021 - 2023
  • Novel development ofan acoustofluidic device for targeted antibody removal in pediatric organ transplan rejection awarded by National Institutes of Health 2021 - 2023
  • Acoustic Device to Prevent Antibody Mediated Organ Transplant Failure awarded by Hartwell Foundation 2019 - 2023
  • CareDx-Self Mgmt Mobile App awarded by CareDx, Inc. 2020 - 2022
  • Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant awarded by University of Minnesota 2019 - 2020
  • The impact of Epstein Barr virus infection on the immune response in pediatric transplant recipients awarded by Stanford University 2018 - 2019
• 

  External Relationships

  • CareDx
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • David, Emeraghi, Minghua Zhu, Braden C. Bennett, Daniel Cheng, Paul Schroder, Amanda Nichols, William Parker, Allan D. Kirk, Nancie MacIver, and Eileen T. Chambers. “Undernutrition and Hypoleptinemia Modulate Alloimmunity and CMV-specific Viral Immunity in Transplantation.” Transplantation 105, no. 12 (December 1, 2021): 2554–63. https://doi.org/10.1097/TP.0000000000003743.
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    • Shaw, Brian I., Alejandro Ochoa, Cliburn Chan, Chloe Nobuhara, Rasheed Gbadegesin, Annette M. Jackson, and Eileen T. Chambers. “HLA Loci and Recurrence of Focal Segmental Glomerulosclerosis in Pediatric Kidney Transplantation.” Transplant Direct 7, no. 10 (October 2021): e748. https://doi.org/10.1097/TXD.0000000000001201.
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    • Shaw, Brian I., Hui-Jie Lee, Cliburn Chan, Robert Ettenger, Paul Grimm, Meghan Pearl, Elaine F. Reed, et al. “Relationship between antithymocyte globulin, T cell phenotypes, and clinical outcomes in pediatric kidney transplantation.” Am J Transplant 21, no. 2 (February 2021): 766–75. https://doi.org/10.1111/ajt.16263.
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    • Chambers, Eileen Tsai. “Role of low-dose calcineurin inhibitor regimens in pediatric kidney transplantation.” Am J Transplant 21, no. 1 (January 2021): 11–12. https://doi.org/10.1111/ajt.16159.
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    • Pearl, Meghan H., Lucia Chen, Rim ElChaki, David Elashoff, David W. Gjertson, Maura Rossetti, Patricia L. Weng, Qiuheng Zhang, Elaine F. Reed, and Eileen Tsai Chambers. “Endothelin Type A Receptor Antibodies Are Associated With Angiotensin II Type 1 Receptor Antibodies, Vascular Inflammation, and Decline in Renal Function in Pediatric Kidney Transplantation.” Kidney Int Rep 5, no. 11 (November 2020): 1925–36. https://doi.org/10.1016/j.ekir.2020.09.004.
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    • Blew, Kathryn H., Annabelle Chua, John Foreman, Rasheed Gbadegesin, Annette Jackson, Shashi Nagaraj, Rebecca Sadun, Del Wigfall, Allan D. Kirk, and Eileen T. Chambers. “Tailored use of belatacept in adolescent kidney transplantation.” Am J Transplant 20, no. 3 (March 2020): 884–88. https://doi.org/10.1111/ajt.15611.
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    • Shaw, Brian I., Daniel K. Cheng, Chaitanya R. Acharya, Robert B. Ettenger, Herbert Kim Lyerly, Qing Cheng, Allan D. Kirk, and Eileen T. Chambers. “An age-independent gene signature for monitoring acute rejection in kidney transplantation.” Theranostics 10, no. 15 (2020): 6977–86. https://doi.org/10.7150/thno.42110.
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    • Chambers, Eileen Tsai, and Rasheed A. Gbadegesin. “Aberrant IgM on T cells: biomarker or pathogenic factor in childhood nephrotic syndrome?” Kidney Int 96, no. 4 (October 2019): 818–20. https://doi.org/10.1016/j.kint.2019.05.031.
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    • Pearl, Meghan H., Jonathan Grotts, Maura Rossetti, Qiuheng Zhang, David W. Gjertson, Patricia Weng, David Elashoff, Elaine F. Reed, and Eileen Tsai Chambers. “Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies.” Kidney Int Rep 4, no. 4 (April 2019): 541–50. https://doi.org/10.1016/j.ekir.2018.12.011.
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    • Pelletier, Jonathan H., Karan R. Kumar, Rachel Engen, Adam Bensimhon, Jennifer D. Varner, Michelle N. Rheault, Tarak Srivastava, et al. “Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study.” Pediatr Nephrol 34, no. 3 (March 2019): 539. https://doi.org/10.1007/s00467-018-4103-3.
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    • Freischlag, Kyle W., Vivian Chen, Shashi K. Nagaraj, Annabelle N. Chua, Dongfeng Chen, Delbert R. Wigfall, John W. Foreman, Rasheed Gbadegesin, Deepak Vikraman, and Eileen T. Chambers. “Psychosocial Assessment of Candidates for Transplantation (PACT) Score Identifies High Risk Patients in Pediatric Renal Transplantation.” Front Pediatr 7 (2019): 102. https://doi.org/10.3389/fped.2019.00102.
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    • Pelletier, Jonathan H., Karan R. Kumar, Rachel Engen, Adam Bensimhon, Jennifer D. Varner, Michelle N. Rheault, Tarak Srivastava, et al. “Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings.” Pediatr Nephrol 33, no. 10 (October 2018): 1773–80. https://doi.org/10.1007/s00467-018-3994-3.
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    • Pearl, Meghan H., Qiuheng Zhang, Miguel Fernando Palma Diaz, Jonathan Grotts, Maura Rossetti, David Elashoff, David W. Gjertson, Patricia Weng, Elaine F. Reed, and Eileen Tsai Chambers. “Angiotensin II Type 1 receptor antibodies are associated with inflammatory cytokines and poor clinical outcomes in pediatric kidney transplantation.” Kidney Int 93, no. 1 (January 2018): 260–69. https://doi.org/10.1016/j.kint.2017.06.034.
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    • Weng, Patricia L., Juan Carlos Alejos, Nancy Halnon, Qiuheng Zhang, Elaine F. Reed, and Eileen Tsai Chambers. “Long-term outcomes of simultaneous heart and kidney transplantation in pediatric recipients.” Pediatr Transplant 21, no. 7 (November 2017). https://doi.org/10.1111/petr.13023.
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    • Ettenger, R., H. Chin, K. Kesler, N. Bridges, P. Grimm, E. F. Reed, M. Sarwal, et al. “Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation.” Am J Transplant 17, no. 6 (June 2017): 1549–62. https://doi.org/10.1111/ajt.14169.
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    • Hickey, Michelle J., Ying Zheng, Nicole Valenzuela, Qiuheng Zhang, Carolyn Krystal, Erik Lum, Eileen W. Tsai, et al. “New priorities: Analysis of the New Kidney Allocation System on UCLA patients transplanted from the deceased donor waitlist.” Human Immunology 78, no. 1 (January 2017): 41–48. https://doi.org/10.1016/j.humimm.2016.10.020.
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    • Pizzo, Helen P., Robert B. Ettenger, David W. Gjertson, Elaine F. Reed, Jennifer Zhang, H Albin Gritsch, and Eileen W. Tsai. “Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence.” Pediatric Nephrology 31, no. 12 (December 2016): 2345–52. https://doi.org/10.1007/s00467-016-3422-5.
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    • Freischlag, Kyle, Meghan H. Pearl, and Eileen T. Chambers. “The Clinical Impact of Non-HLA Antibodies in Solid Organ Transplantation.” Clin Transpl 32 (2016): 31–43.
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    • Tsai, Eileen W., Pornpimol Rianthavorn, David W. Gjertson, William D. Wallace, Elaine F. Reed, and Robert B. Ettenger. “CD20+ Lymphocytes in Renal Allografts Are Associated with Poor Graft Survival in Pediatric Patients.” Transplantation 82, no. 12 (December 27, 2006): 1769–73. https://doi.org/10.1097/01.tp.0000250572.46679.45.
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  • Book Sections

    • Chambers, E. T., and A. D. Kirk. “Antilymphocyte globulin, monoclonal antibodies, and fusion proteins.” In Kidney Transplantation - Principles and Practice, 283–312, 2019. https://doi.org/10.1016/B978-0-323-53186-3.00019-X.
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    • Shaw, B. I., and E. T. Chambers. “Precision medicine in solid organ transplantation.” In Genomic and Precision Medicine: Infectious and Inflammatory Disease, 401–12, 2019. https://doi.org/10.1016/B978-0-12-801496-7.00020-4.
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    • Pelletier, J. H., E. E. David, A. N. Chua, and E. T. Chambers. “Acute and chronic kidney transplant rejection in adolescents: Causes and treatment.” In Adolescents with Chronic Kidney Disease: From Diagnosis to End-Stage Disease, 247–68, 2018. https://doi.org/10.1007/978-3-319-97220-6_15.
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  • Conference Papers

    • David, E., M. Zhu, W. Parker, N. MacIver, A. D. Kirk, and E. T. Chambers. “The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses.” In American Journal of Transplantation, 20:749–749, 2020.
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    • David, E., M. Zhu, W. Parker, N. MacIver, A. D. Kirk, and E. T. Chambers. “Undernutrition and Hypoleptinemia Modulate Cytomegalovirus Infection.” In American Journal of Transplantation, 20:749–50, 2020.
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    • Pearl, M., E. T. Chambers, A. Kirk, R. Garro, B. L. Warshaw, P. Grimm, R. Ettenger, and E. Reed. “Angiotensin II Type 1 Receptor Antibodies are Associated with Younger Age and Renal Dysfunction in Pediatric Kidney Transplantation.” In American Journal of Transplantation, 20:475–76, 2020.
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    • Shaw, B. I., H. Lee, C. Chan, R. B. Ettenger, P. Grimm, E. F. Reed, M. Sarwal, et al. “Obesity and Terminally Differentiated T Cells in Pediatric Kidney Transplantation.” In American Journal of Transplantation, 20:1012–1012, 2020.
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    • Chambers, E. T., C. Chan, R. Ettenger, P. Grimm, E. Reed, M. Sarwal, L. Stempora, et al. “Undernutrition is Associated with Impaired T Cell Protective Immunity in Pediatric Kidney Transplantation.” In American Journal of Transplantation, 19:373–373. WILEY, 2019.
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    • Chambers, E. T., O. Martinez, M. Robien, C. Chan, R. Ettenger, P. Grimm, H. Lee, et al. “NK Cells Are Associated with Alloimmune Failure in Transplanted Children.” In American Journal of Transplantation, 19:339–339. WILEY, 2019.
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    • Shaw, B. I., D. K. Cheng, Q. Cheng, C. R. Acharya, A. D. Kirk, and E. T. Chambers. “A Novel Genomic Approach for Acute Rejection across All Age Groups in Kidney Transplantation.” In American Journal of Transplantation, 19:519–519. WILEY, 2019.
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    • Shaw, B. I., L. Stempora, C. Chan, R. B. Ettenger, P. C. Grimm, H. Lee, E. F. Reed, et al. “Antithymocyte Globulin is Associated with Mature T Cell Phenotypes and Decreased Risk of Non-EBV Infections in Transplanted Children.” In American Journal of Transplantation, 19:466–67. WILEY, 2019.
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    • Chambers, E. T., R. Ettenger, H. -. J. Lee, C. Chan, L. Stempora, B. Warshaw, P. Grimm, E. F. Reed, M. Sarwal, and A. Kirk. “T cell Phenotypes Predict Infectious Risk in Transplanted Children.” In American Journal of Transplantation, 18:476–476. WILEY, 2018.
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    • Pearl, M., J. Grotts, M. Rossetti, Q. Zhang, P. Weng, E. Reed, and E Tsai Chambers. “Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients.” In American Journal of Transplantation, 18:268–268. WILEY, 2018.
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