Eda K Holl | Scholars@Duke

Eda K Holl
Adjunct Assistant Professor in the Department of Surgery

Current Research Interests

Traditionally, researchers have investigated the impact of aberrant inflammation on the development of autoimmune disorders. We now appreciate that this concept spreads beyond autoimmunity. Inflammation that has been misregulated can affect how we respond to pathogenic challenge as well as cancer surveillance. My research efforts have focused on identifying ways to modulate both beneficial and detrimental inflammation to treat various immune disorders and cancer. We are currently developing molecular therapeutic compounds to control unresolved inflammation that can lead to autoimmunity. Additionally, we are utilizing several immunotherapy approaches (vaccines, oncolytic viruses and immune checkpoint molecules) to elicit anti-tumor responses in immunologically cold tumors, in order to uncover mechanisms of immune resistance in tumors. We combine our pre-clinical studies with ongoing clinical work to best address current clinical needs across different disease types.

Current Appointments & Affiliations

Adjunct Assistant Professor in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2020
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

DUMC 103035, Durham, NC 27710
PO Box 103035, Durham, NC 27710
eda.holl@duke.edu (919) 960-7078

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2010
Previous Appointments & Affiliations
- Assistant Professor of Surgery, Surgery, Surgical Sciences, Surgery 2014 - 2020
Research
Selected Grants
- Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer awarded by Department of Defense 2016 - 2024
- Tumor draining lymph node B cells as regulators of melanoma progression awarded by Department of Defense 2020 - 2021
- Targeting DAMP-induced inflammation to prevent metastasis awarded by Department of Defense 2016 - 2020
- Therapeutic Targeting of B7-H3 to Reverse Prostate Cancer Treatment Resistance awarded by Department of Defense 2016 - 2020
- Retrospective Review Evaluating the PSA Changes in Patients with Metastatic Castrate Resistant Prostate Cancer after Sipuleucel-T treatment awarded by Dendreon Corporation 2015 - 2017
- Regulation of inflammatory responses by nucleic-acid binding polymers awarded by National Institutes of Health 2012 - 2014
- Nucleic Acid Binding Polymers as Anti-Inflammatory Agents awarded by National Institutes of Health 2011 - 2013
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Beasley, Georgia M., Michael C. Brown, Norma E. Farrow, Karenia Landa, Rami N. Al-Rohil, Maria Angelica Selim, Aaron D. Therien, et al. “Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma.” J Immunother Cancer 10, no. 9 (September 2022). https://doi.org/10.1136/jitc-2022-005052.
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  - Therien, Aaron D., Georgia M. Beasley, Kristen E. Rhodin, Norma E. Farrow, Douglas S. Tyler, David Boczkowski, Rami N. Al-Rohil, Eda K. Holl, and Smita K. Nair. “Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis.” Front Immunol 13 (2022): 952220. https://doi.org/10.3389/fimmu.2022.952220.
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  - Farrow, Norma E., Eda K. Holl, Jeanne Jung, Junheng Gao, Sin-Ho Jung, Rami N. Al-Rohil, Maria A. Selim, et al. “Characterization of Sentinel Lymph Node Immune Signatures and Implications for Risk Stratification for Adjuvant Therapy in Melanoma.” Ann Surg Oncol 28, no. 7 (July 2021): 3501–10. https://doi.org/10.1245/s10434-020-09277-w.
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  - Holl, Eda K., Victoria Frazier, Karenia Landa, David Boczkowski, Bruce Sullenger, and Smita K. Nair. “Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer.” Mol Ther 29, no. 5 (May 5, 2021): 1772–81. https://doi.org/10.1016/j.ymthe.2020.12.026.
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  - Brown, Michael C., Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, et al. “Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.” Nat Commun 12, no. 1 (March 25, 2021): 1858. https://doi.org/10.1038/s41467-021-22088-1.
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  - Beasley, Georgia M., Aaron D. Therien, Eda K. Holl, Rami Al-Rohil, Maria Angelica Selim, Nellie E. Farrow, Liuliu Pan, et al. “Dissecting the immune landscape of tumor draining lymph nodes in melanoma with high-plex spatially resolved protein detection.” Cancer Immunol Immunother 70, no. 2 (February 2021): 475–83. https://doi.org/10.1007/s00262-020-02698-2.
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  - Johnston, Ashley W., Jonathan C. Routh, J Todd Purves, John S. Wiener, Angela Sinani, and Eda K. Holl. “Immune Expression in Children With Vesicoureteral Reflux: A Pilot Study.” Urology 148 (February 2021): 254–59. https://doi.org/10.1016/j.urology.2020.10.003.
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  - Holl, Eda K., Megan A. McNamara, Patrick Healy, Monika Anand, Raoul S. Concepcion, Coleman D. Breland, Igor Dumbudze, et al. “Prolonged PSA stabilization and overall survival following sipuleucel-T monotherapy in metastatic castration-resistant prostate cancer patients.” Prostate Cancer Prostatic Dis 22, no. 4 (December 2019): 588–92. https://doi.org/10.1038/s41391-019-0144-3.
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  - Holl, E. K., J. C. Routh, A. W. Johnston, V. Frazier, H. E. Rice, E. T. Tracy, and S. K. Nair. “Immune expression in children with Wilms tumor: a pilot study.” J Pediatr Urol 15, no. 5 (October 2019): 441.e1-441.e8. https://doi.org/10.1016/j.jpurol.2019.03.011.
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  - Holl, Eda K., Victoria N. Frazier, Karenia Landa, Georgia M. Beasley, E Shelley Hwang, and Smita K. Nair. “Examining Peripheral and Tumor Cellular Immunome in Patients With Cancer.” Front Immunol 10 (2019): 1767. https://doi.org/10.3389/fimmu.2019.01767.
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  - Brown, Michael C., Eda K. Holl, David Boczkowski, Elena Dobrikova, Mubeen Mosaheb, Vidya Chandramohan, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.” Sci Transl Med 9, no. 408 (September 20, 2017). https://doi.org/10.1126/scitranslmed.aan4220.
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  - Holl, Eda K., Michael C. Brown, David Boczkowski, Megan A. McNamara, Daniel J. George, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.” Oncotarget 7, no. 48 (November 29, 2016): 79828–41. https://doi.org/10.18632/oncotarget.12975.
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  - Holl, E. K., K. L. Shumansky, L. B. Borst, A. D. Burnette, C. J. Sample, E. A. Ramsburg, and B. A. Sullenger. “Erratum: Scavenging nucleic acid debris to combat autoimmunity and infectious disease (Proceedings of the National Academy of Sciences of the United States of America (2016) 113: 35 (9728-9733) DOI: 10.1073/pnas.1607011113).” Proceedings of the National Academy of Sciences of the United States of America 113, no. 42 (October 18, 2016): E6545. https://doi.org/10.1073/pnas.1615444113.
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  - Holl, Eda K., Kara L. Shumansky, Luke B. Borst, Angela D. Burnette, Christopher J. Sample, Elizabeth A. Ramsburg, and Bruce A. Sullenger. “Scavenging nucleic acid debris to combat autoimmunity and infectious disease.” Proc Natl Acad Sci U S A 113, no. 35 (August 30, 2016): 9728–33. https://doi.org/10.1073/pnas.1607011113.
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  - Holl, Eda K., Irving C. Allen, and Jennifer Martinez. “Holding the Inflammatory System in Check: TLRs and NLRs.” Mediators Inflamm 2016 (2016): 8156816. https://doi.org/10.1155/2016/8156816.
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  - McNamara, Megan A., Smita K. Nair, and Eda K. Holl. “RNA-Based Vaccines in Cancer Immunotherapy.” J Immunol Res 2015 (2015): 794528. https://doi.org/10.1155/2015/794528.
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  - Holl, Eda K., Jennifer E. Bond, Maria A. Selim, Tosan Ehanire, Bruce Sullenger, and Howard Levinson. “The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction.” Plast Reconstr Surg 134, no. 3 (September 2014): 420e-433e. https://doi.org/10.1097/PRS.0000000000000471.
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  - Holl, Eda K. “Generation of bone marrow and fetal liver chimeric mice.” Methods Mol Biol 1032 (2013): 315–21. https://doi.org/10.1007/978-1-62703-496-8_24.
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  - Holl, Eda K., Kara L. Shumansky, George Pitoc, Elizabeth Ramsburg, and Bruce A. Sullenger. “Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses.” Plos One 8, no. 7 (2013): e69413. https://doi.org/10.1371/journal.pone.0069413.
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  - Roney, Kelly, Eda Holl, and Jenny Ting. “Immune plexins and semaphorins: old proteins, new immune functions.” Protein Cell 4, no. 1 (January 2013): 17–26. https://doi.org/10.1007/s13238-012-2108-4.
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  - Schneider, Monika, Albert G. Zimmermann, Reid A. Roberts, Lu Zhang, Karen V. Swanson, Haitao Wen, Beckley K. Davis, et al. “The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.” Nat Immunol 13, no. 9 (September 2012): 823–31. https://doi.org/10.1038/ni.2378.
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  - Jain, Shashank, George A. Pitoc, Eda K. Holl, Ying Zhang, Luke Borst, Kam W. Leong, Jaewoo Lee, and Bruce A. Sullenger. “Nucleic acid scavengers inhibit thrombosis without increasing bleeding.” Proc Natl Acad Sci U S A 109, no. 32 (August 7, 2012): 12938–43. https://doi.org/10.1073/pnas.1204928109.
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  - Holl, Eda K., Kelly E. Roney, Irving C. Allen, Erin Steinbach, Janelle C. Arthur, Adam Buntzman, Scott Plevy, Jeffrey Frelinger, and Jenny P-Y Ting. “Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production.” Plos One 7, no. 8 (2012): e43333. https://doi.org/10.1371/journal.pone.0043333.
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  - Holl, Eda K., Brian P. O’Connor, T Matt Holl, Kelly E. Roney, Albert G. Zimmermann, Sushmita Jha, Garnett Kelsoe, and Jenny P-Y Ting. “Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.” J Immunol 186, no. 10 (May 15, 2011): 5603–11. https://doi.org/10.4049/jimmunol.1003464.
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  - Roney, Kelly E., Brian P. O’Connor, Haitao Wen, Eda K. Holl, Elizabeth H. Guthrie, Beckley K. Davis, Stephen W. Jones, et al. “Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation.” Plos One 6, no. 9 (2011): e24795. https://doi.org/10.1371/journal.pone.0024795.
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  - Allen, Irving C., Erin McElvania TeKippe, Rita-Marie T. Woodford, Joshua M. Uronis, Eda K. Holl, Arlin B. Rogers, Hans H. Herfarth, Christian Jobin, and Jenny P-Y Ting. “The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.” J Exp Med 207, no. 5 (May 10, 2010): 1045–56. https://doi.org/10.1084/jem.20100050.
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  - Allen, Irving C., Margaret A. Scull, Chris B. Moore, Eda K. Holl, Erin McElvania-TeKippe, Debra J. Taxman, Elizabeth H. Guthrie, Raymond J. Pickles, and Jenny P-Y Ting. “The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.” Immunity 30, no. 4 (April 17, 2009): 556–65. https://doi.org/10.1016/j.immuni.2009.02.005.
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  - O’Connor, Brian P., So-Young Eun, Zhengmao Ye, Alla L. Zozulya, John D. Lich, Chris B. Moore, Heather A. Iocca, et al. “Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.” Proc Natl Acad Sci U S A 105, no. 35 (September 2, 2008): 13015–20. https://doi.org/10.1073/pnas.0803386105.
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Scholarly, Clinical, & Service Activities
Service to Duke
- IRB. 2015 2015

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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles

Service to Duke