Overview
Program Start Year: 2020
Mari Shinohara Laboratory
Mari Shinohara Laboratory
Recent Publications
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense.
Journal Article Mucosal Immunol · October 2024 The olfactory mucosa is important for both the sense of smell and as a mucosal immune barrier to the upper airway and brain. However, little is known about how the immune system mediates the conflicting goals of neuronal maintenance and inflammation in thi ... Full text Link to item CiteLoss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.
Journal Article Nat Commun · October 6, 2022 Production of a functional peripheral T cell compartment typically involves massive expansion of the bone marrow progenitors that seed the thymus. There are two main phases of expansion during T cell development, following T lineage commitment of double-ne ... Full text Link to item CiteNeutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis.
Journal Article Biomedicines · August 2020 Aberrant neutrophil extracellular trap (NET) formation and the loss of barrier integrity in inflamed intestinal tissues have long been associated with inflammatory bowel disease (IBD). However, whether NETs alter intestinal epithelium permeability during c ... Full text CiteRecent Grants
Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infections
ResearchResearch Assistant · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026Protective role of Clec7a/dectin-1 in CNS autoimmunity
ResearchResearch Assistant · Awarded by National Institute of Neurological Disorders and Stroke · 2020 - 2025View All Grants