Scholars@Duke
Emily Fahrig Cole

Emily Fahrig Cole

Assistant Professor of Dermatology
Dermatology
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Selected Publications

Quantitative sensory testing in notalgia paresthetica reveals small fiber-type-specific differences in non-pruritic sensitivity: a pilot study.

Journal Article Pain reports · August 2024 IntroductionNotalgia paresthetica (NP) is a chronic condition characterized by pruritus and other unpleasant dysesthetic sensations unilaterally on the subscapular back. Its specific underlying mechanisms are largely unknown, though hypothesized t ... Full text Cite

Efficacy and Safety of Systemic Corticosteroids for Urticaria: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Journal Article J Allergy Clin Immunol Pract · April 18, 2024 BACKGROUND: Short courses of adjunctive systemic corticosteroids are commonly used to treat acute urticaria and chronic urticaria flares (both with and without mast cell-mediated angioedema), but their benefits and harms are unclear. OBJECTIVE: To evaluate ... Full text Link to item Cite

Comparing Clinical Outcomes of Steroid-Sparing Therapy With Rituximab Versus Rituximab Alone in Pemphigus.

Journal Article J Drugs Dermatol · March 1, 2024 BACKGROUND: Previous clinical trials have demonstrated that rituximab therapy combined with conventional steroid-sparing therapy (SST) has increased rates of disease control for mucous membrane pemphigoid compared with rituximab alone. However, limited dat ... Full text Link to item Cite

Correlation between PainDETECT Questionnaire and Quantitative Sensory Testing for the Detection of Neuropathic Pain in Hidradenitis Suppurativa.

Journal Article Dermatology · 2024 BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that is often severely painful due to nociceptive mechanisms (i.e., stimulation of cutaneous nociceptors). However, patient-reported pain character suggests that neuropathy ma ... Full text Link to item Cite

United States expert panel consensus on uniform nomenclature and diagnosis for neuropathic pruritus

Journal Article Itch · January 2024 Importance:Neuropathic pruritus is a debilitating condition lacking a uniform approach to nomenclature and diagnosis. Full text Cite

Quantitative Sensory Testing to Characterize Sensory Changes in Hidradenitis Suppurativa Skin Lesions.

Journal Article JAMA Dermatol · October 1, 2023 IMPORTANCE: Pain is the most impactful symptom in patients with hidradenitis suppurativa (HS). Characterization of sensory profiles may improve understanding of pain mechanisms in HS and facilitate identification of effective pain management strategies. OB ... Full text Link to item Cite

Transcriptional profiling of cutaneous immunotoxicity from melanoma immunotherapy

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · 2022 Cite

Pain Management Recommendations Among International Hidradenitis Suppurativa Guidelines

Chapter · January 1, 2022 Pain is the most burdensome symptom of hidradenitis suppurativa (HS), accounting for greater impairment in HS-related quality of life (QoL) than even disease severity. Although it has received relatively less attention, pruritus is also common in HS and co ... Full text Cite

Dupilumab-induced erythema nodosum

Journal Article JAAD Case Reports · January 1, 2022 Full text Cite

Assessing Disease Outcome Measures in Bullous Pemphigoid on Standard-Of-Care Therapies.

Journal Article JID Innov · December 2021 Bullous pemphigoid (BP) is an autoimmune blistering disease resulting in pruritus and cutaneous blistering. Longitudinal studies characterizing the disease course of patients with BP on conventional therapy are lacking. We sought to characterize the change ... Full text Link to item Cite

TH2 sensitization in the skin-gut-brain axis: How early-life Th2-mediated inflammation may negatively perpetuate developmental and psychologic abnormalities.

Journal Article Pediatr Dermatol · September 2021 We recently reported children with comorbid atopic dermatitis (AD), asthma, allergic rhinitis, and food allergies displaying a 2.7-fold increase in developmental delays.2 To this end, we hypothesize unregulated increases in T helper-2 (Th2)-driven inflamma ... Full text Link to item Cite

Childhood atopic dermatitis is associated with cognitive dysfunction: A National Health Interview Survey study from 2008 to 2018.

Journal Article Ann Allergy Asthma Immunol · June 2021 BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease in children and adults. Little is known regarding the association of childhood AD with cognitive dysfunction. OBJECTIVE: To evaluate the association of AD and cognitive dysfunction, i ... Full text Link to item Cite

Quantitative sensory testing in notalgia paresthetica reveals small fiber-type-specific differences in non-pruritic sensitivity: a pilot study.

Journal Article Pain reports · August 2024 IntroductionNotalgia paresthetica (NP) is a chronic condition characterized by pruritus and other unpleasant dysesthetic sensations unilaterally on the subscapular back. Its specific underlying mechanisms are largely unknown, though hypothesized t ... Full text Cite

Efficacy and Safety of Systemic Corticosteroids for Urticaria: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Journal Article J Allergy Clin Immunol Pract · April 18, 2024 BACKGROUND: Short courses of adjunctive systemic corticosteroids are commonly used to treat acute urticaria and chronic urticaria flares (both with and without mast cell-mediated angioedema), but their benefits and harms are unclear. OBJECTIVE: To evaluate ... Full text Link to item Cite

Comparing Clinical Outcomes of Steroid-Sparing Therapy With Rituximab Versus Rituximab Alone in Pemphigus.

Journal Article J Drugs Dermatol · March 1, 2024 BACKGROUND: Previous clinical trials have demonstrated that rituximab therapy combined with conventional steroid-sparing therapy (SST) has increased rates of disease control for mucous membrane pemphigoid compared with rituximab alone. However, limited dat ... Full text Link to item Cite

Correlation between PainDETECT Questionnaire and Quantitative Sensory Testing for the Detection of Neuropathic Pain in Hidradenitis Suppurativa.

Journal Article Dermatology · 2024 BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that is often severely painful due to nociceptive mechanisms (i.e., stimulation of cutaneous nociceptors). However, patient-reported pain character suggests that neuropathy ma ... Full text Link to item Cite

United States expert panel consensus on uniform nomenclature and diagnosis for neuropathic pruritus

Journal Article Itch · January 2024 Importance:Neuropathic pruritus is a debilitating condition lacking a uniform approach to nomenclature and diagnosis. Full text Cite

Quantitative Sensory Testing to Characterize Sensory Changes in Hidradenitis Suppurativa Skin Lesions.

Journal Article JAMA Dermatol · October 1, 2023 IMPORTANCE: Pain is the most impactful symptom in patients with hidradenitis suppurativa (HS). Characterization of sensory profiles may improve understanding of pain mechanisms in HS and facilitate identification of effective pain management strategies. OB ... Full text Link to item Cite

Transcriptional profiling of cutaneous immunotoxicity from melanoma immunotherapy

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · 2022 Cite

Pain Management Recommendations Among International Hidradenitis Suppurativa Guidelines

Chapter · January 1, 2022 Pain is the most burdensome symptom of hidradenitis suppurativa (HS), accounting for greater impairment in HS-related quality of life (QoL) than even disease severity. Although it has received relatively less attention, pruritus is also common in HS and co ... Full text Cite

Dupilumab-induced erythema nodosum

Journal Article JAAD Case Reports · January 1, 2022 Full text Cite

Assessing Disease Outcome Measures in Bullous Pemphigoid on Standard-Of-Care Therapies.

Journal Article JID Innov · December 2021 Bullous pemphigoid (BP) is an autoimmune blistering disease resulting in pruritus and cutaneous blistering. Longitudinal studies characterizing the disease course of patients with BP on conventional therapy are lacking. We sought to characterize the change ... Full text Link to item Cite

TH2 sensitization in the skin-gut-brain axis: How early-life Th2-mediated inflammation may negatively perpetuate developmental and psychologic abnormalities.

Journal Article Pediatr Dermatol · September 2021 We recently reported children with comorbid atopic dermatitis (AD), asthma, allergic rhinitis, and food allergies displaying a 2.7-fold increase in developmental delays.2 To this end, we hypothesize unregulated increases in T helper-2 (Th2)-driven inflamma ... Full text Link to item Cite

Childhood atopic dermatitis is associated with cognitive dysfunction: A National Health Interview Survey study from 2008 to 2018.

Journal Article Ann Allergy Asthma Immunol · June 2021 BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease in children and adults. Little is known regarding the association of childhood AD with cognitive dysfunction. OBJECTIVE: To evaluate the association of AD and cognitive dysfunction, i ... Full text Link to item Cite

Itch-related quality of life impact across 3 autoimmune blistering diseases: a retrospective cohort study

Journal Article Itch · July 2020 Introduction:Autoimmune blistering diseases (AIBD) produce a range of debilitating symptoms potentially greatly impacting quality of life (QoL). We sought to compare the disease-related a ... Full text Cite

The Quality-of-Life Impact of Chronic Itch Compared to Pain

Chapter · March 20, 2020 Itch and Pain: Similarities, Interactions and Differences is the only available, up-to-date guide to current information in this important area, ideal for basic scientists as well as clinicians in dermatology, pain, neurology, medicine, ... ... Cite

Updates on diagnosis and management of autoimmune blistering diseases.

Journal Article G Ital Dermatol Venereol · February 2020 Over the last several decades, advances in the understanding of the pathogenesis of autoimmune blistering diseases has resulted in significant improvements in diagnosis and management. These improvements include new diagnostic assays and therapies targeted ... Full text Link to item Cite

The Effects of Surgery Type and Chemotherapy on Early-Stage Breast Cancer Patients' Quality of Life Over 2-Year Follow-up.

Journal Article Ann Surg Oncol · March 2016 BACKGROUND: We examined the effects of surgery type and adjuvant chemotherapy on change in early-stage breast cancer patients' quality of life (QOL) over time. METHODS: A cohort of 549 patients (33.5% ductal carcinoma in situ, 66.5% stages I/IIA) were inte ... Full text Link to item Cite

Neurocutaneous disease: Neurocutaneous dysesthesias.

Journal Article J Am Acad Dermatol · February 2016 Dysesthesia is a generic term for a cutaneous symptom--such as pruritus, burning, tingling, stinging, anesthesia, hypoesthesia, tickling, crawling, cold sensation, or even pain--without a primary cutaneous condition in a well-defined location that is often ... Full text Link to item Cite

A suture-based liver retraction method for laparoscopic bariatric procedures: results from a large case series.

Journal Article Surg Obes Relat Dis · 2015 BACKGROUND: Laparoscopic bariatric surgery requires retraction of the left lobe of the liver to provide adequate operative view and working space. Conventional approaches utilize a mechanical retractor and require additional incision(s), and at times an as ... Full text Link to item Cite

Capgras syndrome in homocystinuria.

Journal Article Biol Psychiatry · September 15, 2014 Full text Link to item Cite

Social but safe? Quality and safety of diabetes-related online social networks.

Journal Article J Am Med Inform Assoc · May 1, 2011 OBJECTIVE: To foster informed decision-making about health social networking (SN) by patients and clinicians, the authors evaluated the quality/safety of SN sites' policies and practices. DESIGN: Multisite structured observation of diabetes-focused SN site ... Full text Link to item Cite