Scholars@Duke
Emma C Rossi

Emma C Rossi

Associate Professor of Obstetrics and Gynecology
Obstetrics and Gynecology, Gynecologic Oncology

Selected Publications

Relationship between abnormal p53 expression and high-risk histology in endometrial cancers and living in proximity to hog concentrated animal feeding operations in North Carolina.

Journal Article Gynecol Oncol Rep · August 2025 OBJECTIVE: Prior research demonstrated a 2.27-fold increase in uterine cancer mortality among North Carolinians living near hog concentrated animal feeding operations (CAFOs). Endometrial cancer (EC) accounts for 90% of uterine cancer cases. Mutation and a ... Full text Link to item Cite

The doc versus the bot: A pilot study to assess the quality and accuracy of physician and chatbot responses to clinical questions in gynecologic oncology.

Journal Article Gynecol Oncol Rep · October 2024 Artificial intelligence (AI) applications to medical care are currently under investigation. We aimed to evaluate and compare the quality and accuracy of physician and chatbot responses to common clinical questions in gynecologic oncology. In this cross-se ... Full text Link to item Cite

Delayed publication of clinical trials in gynecologic oncology.

Journal Article Gynecol Oncol · April 2024 OBJECTIVES: Delays in clinical trial publication can hinder timely implementation of evidence-based practices. We sought to determine publication rates and time to publication for clinical trials addressing gynecologic malignancies. METHODS: All clinical t ... Full text Link to item Cite

The RECOURSE Study: Long-term Oncologic Outcomes Associated With Robotically Assisted Minimally Invasive Procedures for Endometrial, Cervical, Colorectal, Lung, or Prostate Cancer: A Systematic Review and Meta-analysis.

Journal Article Annals of surgery · March 2023 ObjectiveTo assess long-term outcomes with robotic versus laparoscopic/thoracoscopic and open surgery for colorectal, urologic, endometrial, cervical, and thoracic cancers.BackgroundMinimally invasive surgery provides perioperative benefi ... Full text Cite

Sentinel lymph node biopsy in high-grade endometrial cancer: a systematic review and meta-analysis of performance characteristics.

Journal Article Am J Obstet Gynecol · October 2021 OBJECTIVE: A sentinel lymph node biopsy is widely accepted as the standard of care for surgical staging in low-grade endometrial cancer, but its value in high-grade endometrial cancer remains controversial. The aim of this systematic review and meta-analys ... Full text Link to item Cite

Development of a surgical competency assessment tool for sentinel lymph node dissection by minimally invasive surgery for endometrial cancer.

Journal Article Int J Gynecol Cancer · May 2021 INTRODUCTION: Sentinel lymph node dissection is widely used in the staging of endometrial cancer. Variation in surgical techniques potentially impacts diagnostic accuracy and oncologic outcomes, and poses barriers to the comparison of outcomes across insti ... Full text Link to item Cite

Sentinel lymph node (SLN) isolated tumor cells (ITCs) in otherwise stage I/II endometrioid endometrial cancer: To treat or not to treat?

Journal Article Gynecol Oncol · May 2021 OBJECTIVES: To assess associations between treatment and recurrence-free survival (RFS) among patients with isolated tumor cells (ITCs) in sentinel lymph nodes (SLN) and otherwise stage I/II endometrioid endometrial cancer (EC). METHODS: A multi-institutio ... Full text Link to item Cite

Genomic profiling of endometrial cancer and relationship with volume of endometrial cancer disease spread

Journal Article Gynecologic Oncology Reports · May 1, 2021 Objectives: Lymph node (LN) metastasis and genomic profiles are important prognostic factors in endometrial cancer (EMCA). However, the prognostic significance of low volume metastasis found in sentinel lymph nodes (SLN) is unknown. We sought to determine ... Full text Cite

Implementation and evaluation of a novel subspecialty society fellows robotic surgical course: the SGO minimally invasive academy surgical curriculum.

Journal Article J Gynecol Oncol · March 2021 OBJECTIVE: To evaluate the utility of a society-based robotic surgery training program for fellows in gynecologic oncology. METHODS: All participants underwent a 2-day robotic surgery training course between 2015-2017. The course included interactive didac ... Full text Link to item Cite

Controversies in Sentinel Lymph Node Biopsy for Gynecologic Malignancies.

Journal Article J Minim Invasive Gynecol · March 2021 OBJECTIVE: Sentinel lymph node (SLN) biopsy represents an evolution in the advancement of minimally invasive surgical techniques for gynecologic cancers. Prospective and retrospective studies have consistently shown its accuracy in the detection of lymph n ... Full text Link to item Cite

When to operate, hesitate and reintegrate: society of gynecologic oncology surgical considerations during the covid-19 pandemic

Journal Article Obstetrical and Gynecological Survey · January 1, 2021 The COVID-19 pandemic has challenged our abilities to provide timely surgical care for patients, including women with gynecologic cancer. In March 2020, the American College of Surgeons, The US Surgeon General, and many medical and surgical academic societ ... Full text Cite

When to Operate, Hesitate and Reintegrate: Society of Gynecologic Oncology Surgical Considerations during the COVID-19 Pandemic.

Journal Article Gynecol Oncol · August 2020 The COVID-19 pandemic has challenged our ability to provide timely surgical care for our patients. In response, the U.S. Surgeon General, the American College of Srugeons, and other surgical professional societies recommended postponing elective surgical p ... Full text Link to item Cite

Defining the learning curve for successful staging with sentinel lymph node biopsy for endometrial cancer among surgeons at an academic institution.

Journal Article Int J Gynecol Cancer · March 2020 BACKGROUND: Sentinel lymph node (SLN) biopsy is increasingly used in endometrial cancer staging; however, success of the technique is variable, and the learning curve needs to be better understood. Success is defined as identification of a SLN specimen con ... Full text Link to item Cite

Current state of sentinel lymph nodes for women with endometrial cancer.

Journal Article Int J Gynecol Cancer · March 2019 Sentinel lymph node (SLN) biopsy has been investigated as an alternative to conventional pelvic and para-aorticlymphadenectomy for the surgical staging of endometrial cancer. Clinical trials have established the accuracy of sentinel nodes in the detecting ... Full text Link to item Cite

Extent of lymphadenectomy and postoperative major complications among women with endometrial cancer treated with minimally invasive surgery.

Journal Article Am J Obstet Gynecol · March 2019 BACKGROUND: In patients with endometrial cancer, sentinel lymphadenectomy is used to accurately prognosticate extent of disease, and has been proposed as a method to decrease the incidence of medical and surgical complications associated with more extensiv ... Full text Link to item Cite

Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103).

Journal Article Cancer Chemother Pharmacol · January 2019 PURPOSE: The primary objective of this study was to determine the recommended dose of the vascular disrupting agent, BNC105P, in combination with gemcitabine and carboplatin in patients with ovarian cancer in first or second relapse with a minimum 4 month ... Full text Link to item Cite

Benign hysterectomy performed by gynecologic oncologists: Is selection bias altering our ability to measure surgical quality?

Journal Article Gynecol Oncol · October 2018 OBJECTIVE: To compare the characteristics of women undergoing hysterectomy for benign disease with either a benign gynecologist or a gynecologic oncologist and to assess for differences in complication rates with and without risk adjustment. METHODS: Patie ... Full text Link to item Cite

Surgical readmission and survival in women with ovarian cancer: Are short-term quality metrics incentivizing decreased long-term survival?

Journal Article Gynecol Oncol · December 2017 OBJECTIVES: To determine the association between treatment with neoadjuvant chemotherapy (NACT) or primary debulking surgery (PDS) and readmission after surgical hospitalization as well as overall survival among women with stage IIIC epithelial ovarian can ... Full text Link to item Cite

Sentinel Lymph Node Biopsy in Endometrial Cancer: a New Standard of Care?

Journal Article Curr Treat Options Oncol · September 18, 2017 Lymph node status is one of the most important factors in determining prognosis and the need for adjuvant treatment in endometrial cancer (EMCA). Unfortunately, full lymphadenectomy bears significant surgical and postoperative risks. The majority of patien ... Full text Link to item Cite

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations.

Journal Article Gynecol Oncol · August 2017 The emphasis in contemporary medical oncology has been "precision" or "personalized" medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node ... Full text Link to item Cite

Variation in neoadjuvant chemotherapy utilization for epithelial ovarian cancer at high volume hospitals in the United States and associated survival.

Journal Article Gynecol Oncol · June 2017 OBJECTIVE: To estimate variation in the use of neoadjuvant chemotherapy by high volume hospitals and to determine the association between hospital utilization of neoadjuvant chemotherapy and survival. METHODS: We identified incident cases of stage IIIC or ... Full text Link to item Cite

Sentinel Lymph Node Technique in Endometrial Cancer.

Journal Article Obstet Gynecol Surv · May 2017 IMPORTANCE: Endometrial cancer (EMCA) is the most common gynecologic malignancy, with an estimated 54,000 new cases and 10,000 deaths in the United States in 2015. Lymph node metastasis is the most significant prognostic factor in EMCA. Sentinel lymph node ... Full text Link to item Cite

A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.

Journal Article Lancet Oncol · March 2017 BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold ... Full text Link to item Cite

Detection of sentinel nodes for endometrial cancer with robotic assisted fluorescence imaging: cervical versus hysteroscopic injection.

Journal Article Int J Gynecol Cancer · November 2013 OBJECTIVE: Sentinel lymph node (SLN) mapping with indocyanine green (ICG) detected by robotic near infrared (NIR) imaging is a feasible technique. The optimal site of injection (cervical or endometrial) for endometrial cancer has yet to be determined. We p ... Full text Link to item Cite

A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth.

Journal Article Mol Cancer Ther · May 2013 Secreted frizzled-related protein 2 (SFRP2) is overexpressed in human angiosarcoma and breast cancer and stimulates angiogenesis via activation of the calcineurin/NFATc3 pathway. There are conflicting reports in the literature as to whether SFRP2 is an ant ... Full text Link to item Cite

Is bilateral lymphadenectomy for midline squamous carcinoma of the vulva always necessary? An analysis from Gynecologic Oncology Group (GOG) 173.

Journal Article Gynecol Oncol · February 2013 OBJECTIVE: To determine which patients with near midline lesions may safely undergo unilateral groin dissection based on clinical exam and lymphoscintigraphy (LSG) results. METHODS: Patients participating in GOG-173 underwent sentinel lymph node (SLN) loca ... Full text Link to item Cite

Cytokine use and survival in the first-line treatment of ovarian cancer: a Gynecologic Oncology Group Study.

Conference Gynecol Oncol · December 2012 BACKGROUND: Granulocyte colony stimulating factor (G-CSF) and erythropoietin stimulating agents (ESA) may be used to support patients during chemotherapy. We assessed whether G-CSF or ESA were associated with progression or death in patients with ovarian c ... Full text Link to item Cite

Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study.

Journal Article J Clin Oncol · November 1, 2012 PURPOSE: To determine the safety of sentinel lymph node biopsy as a replacement for inguinal femoral lymphadenectomy in selected women with vulvar cancer. PATIENTS AND METHODS: Eligible women had squamous cell carcinoma, at least 1-mm invasion, and tumor s ... Full text Link to item Cite

Minimally invasive surgery versus laparotomy in women with high grade endometrial cancer: a multi-site study performed at high volume cancer centers.

Journal Article Gynecol Oncol · August 2012 OBJECTIVE: The study aim was to compare outcomes in women with high-grade endometrial cancer (EC) who underwent surgical staging via minimally invasive surgery (MIS) versus laparotomy. METHODS: This is a retrospective, multi-institutional cohort study of p ... Full text Link to item Cite

Robotically assisted fluorescence-guided lymph node mapping with ICG for gynecologic malignancies: a feasibility study.

Journal Article Gynecol Oncol · January 2012 OBJECTIVE: Traditional techniques of sentinel lymph node (SLN) mapping for endometrial and cervical cancer present challenges which may be overcome with newer technologies such as near infrared (NIR) imaging of the fluorescent dye Indocyanine green (ICG). ... Full text Link to item Cite

Tumor diameter as a predictor in endometrial cancer surgery: Yanazume, et al.

Journal Article American Journal of Obstetrics and Gynecology · June 1, 2011 Full text Cite

Discussion: 'Tumor diameter as a predictor in endometrial cancer surgery' by Yanazume et al.

Journal Article Am J Obstet Gynecol · June 2011 In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Yanazume S, Saito T, Eto T, et al. Reassessment o ... Full text Link to item Cite

Ovarian Sex Cord-Stromal Tumors

Chapter · October 7, 2009 Full text Cite

Perioperative outcomes of robotically assisted hysterectomy for benign cases with complex pathology.

Journal Article Obstet Gynecol · September 2009 OBJECTIVE: To report on the perioperative outcomes after robotically assisted total hysterectomy for benign indications in a large patient population with predominantly complex pathology. METHODS: One hundred fifty-two patients underwent robotic hysterecto ... Full text Link to item Cite

The ponderal index in triplets: IV. Relationship with maternal height.

Journal Article J Perinat Med · 2004 The purpose of the study was to further evaluate the relationship between maternal height and neonatal ponderal index and length. A total of 774 triplet sets with matched maternal stature was available for analyses. We found a significant correlation betwe ... Full text Link to item Cite