Scholars@Duke
David Scott Enterline

David Scott Enterline

Consulting Associate in the Department of Radiology
Radiology, Neuroradiology
enter001@mc.duke.edu
Box 3808 Med Ctr, Durham, NC 27710
1531A Hosp North, Durham, NC 27710

Selected Publications

High Spatial-Resolution Skull Base Imaging With Photon-Counting Computed Tomography and Energy-Integrating Computed Tomography: A Comparative Phantom Study.

Journal Article J Comput Assist Tomogr · July 2023 Photon-counting computed tomography (PCCT) offers better high-resolution and noise performance than energy integrating detector (EID) CT. In this work, we compared both technologies for imaging of the temporal bone and skull base. A clinical PCCT system an ... Full text Link to item Cite

Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models.

Journal Article Sci Transl Med · February 8, 2023 D2C7-immunotoxin (IT), a dual-specific IT targeting wild-type epidermal growth factor receptor (EGFR) and mutant EGFR variant III (EGFRvIII) proteins, demonstrates encouraging survival outcomes in a subset of patients with glioblastoma. We hypothesized tha ... Full text Link to item Cite

Juxtametallic Bipolar Bone Radiofrequency Ablation: Thermal Monitoring in an Ex-Vivo Model with Specimen MRI and Histopathologic Correlation.

Journal Article J Vasc Interv Radiol · December 2022 PURPOSE: To measure the ablation zone temperature and nontarget tissue temperature during radiofrequency (RF) ablation in bone containing metal instrumentation versus no metal instrumentation (control group). MATERIALS AND METHODS: Ex vivo experiments were ... Full text Link to item Cite

Augmented reality overlay fluoroscopic guidance versus CT-fluoroscopic guidance for sacroplasty.

Journal Article Clin Imaging · May 2022 PURPOSE: To evaluate patient outcomes after sacroplasty (percutaneous sacral augmentation) with guidance using CT compared to fluoroscopy with augmented reality overlay using fluoroscopic cone-beam CT and FDA-approved software (CBCT-AF). MATERIALS AND METH ... Full text Link to item Cite

ADC Histogram Analysis of Pediatric Low-Grade Glioma Treated with Selumetinib: A Report from the Pediatric Brain Tumor Consortium.

Journal Article AJNR Am J Neuroradiol · March 2022 BACKGROUND AND PURPOSE: Selumetinib is a promising MAP (mitogen-activated protein) kinase (MEK) 1/2 inhibitor treatment for pediatric low-grade gliomas. We hypothesized that MR imaging-derived ADC histogram metrics would be associated with survival and res ... Full text Link to item Cite

Safety and diagnostic efficacy of gadoteridol for magnetic resonance imaging of the brain and spine in children 2 years of age and younger.

Journal Article Pediatr Radiol · September 2021 BACKGROUND: Neonates and young children require efficacious magnetic resonance imaging (MRI) examinations but are potentially more susceptible to the short- and long-term adverse effects of gadolinium-based contrast agents due to the immaturity of their bo ... Full text Link to item Cite

Safety and Diagnostic Efficacy of Gadobenate Dimeglumine in MRI of the Brain and Spine of Neonates and Infants.

Journal Article AJNR Am J Neuroradiol · December 2019 BACKGROUND AND PURPOSE: Contrast-enhanced MR imaging provides essential information for pediatric imaging applications. We evaluated gadobenate dimeglumine for contrast-enhanced MR imaging of infants younger than 2 years of age. MATERIALS AND METHODS: Nine ... Full text Link to item Cite

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.

Journal Article Lancet Oncol · July 2019 BACKGROUND: Paediatric low-grade glioma is the most common CNS tumour of childhood. Although overall survival is good, disease often recurs. No single universally accepted treatment exists for these patients; however, standard cytotoxic chemotherapies are ... Full text Link to item Cite

Contrast Administration in CT: A Patient-Centric Approach.

Journal Article J Am Coll Radiol · March 2019 Patient-centric care has garnered the attention of the radiology community. The authors describe a patient-centric approach to iodinated contrast administration designed to optimize the diagnostic yield of contrast-enhanced CT while minimizing patient iodi ... Full text Link to item Cite

Neuroimaging findings in infantile Pompe patients treated with enzyme replacement therapy.

Journal Article Molecular genetics and metabolism · February 2018 BackgroundRecombinant human acid α-glucosidase (rhGAA) enzyme replacement therapy (ERT) has prolonged survival in infantile Pompe disease (IPD), but has unmasked central nervous system (CNS) changes.MethodsBrain imaging, consisting of com ... Full text Cite

Principles of T2 *-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging.

Journal Article J Magn Reson Imaging · February 2015 Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is used to track the first pass of an exogenous, paramagnetic, nondiffusible contrast agent through brain tissue, and has emerged as a powerful tool in the characterization of brain tumor ... Full text Link to item Cite

Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics.

Journal Article BMC Med Genomics · June 25, 2014 BACKGROUND: Chiari Type I Malformation (CMI) is characterized by herniation of the cerebellar tonsils through the foramen magnum at the base of the skull, resulting in significant neurologic morbidity. As CMI patients display a high degree of clinical vari ... Full text Open Access Link to item Cite

Vascular communications between donor and recipient tissues after successful full face transplantation.

Journal Article Am J Transplant · March 2014 The vascular reorganization after facial transplantation has important implications on future surgical planning. The purpose of this study was to evaluate blood flow (BF) after full face transplantation using wide area-detector computed tomography (CT) tec ... Full text Link to item Cite

Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation.

Journal Article Annals of human genetics · January 2014 Chiari Type I Malformation (CMI) is characterized by herniation of the cerebellar tonsils through the base of the skull. Although cerebellar tonsillar herniation (CTH) is hypothesized to result from an underdeveloped posterior cranial fossa (PF), patients ... Full text Cite

Estimation of radiation exposure for brain perfusion CT: standard protocol compared with deviations in protocol.

Journal Article AJR Am J Roentgenol · November 2013 OBJECTIVE: The purpose of this study was to measure the organ doses and estimate the effective dose for the standard brain perfusion CT protocol and erroneous protocols. MATERIALS AND METHODS: An anthropomorphic phantom with metal oxide semiconductor field ... Full text Link to item Cite

CT angiography for surgical planning in face transplantation candidates.

Journal Article AJNR Am J Neuroradiol · October 2013 Facial allotransplantation replaces missing facial structures with anatomically identical tissues, providing desired functional, esthetic, and psychosocial benefits far superior to those of conventional methods. On the basis of very encouraging initial res ... Full text Link to item Cite

Perfusion MRI: the five most frequently asked clinical questions.

Journal Article AJR Am J Roentgenol · September 2013 OBJECTIVE: This article addresses questions that radiologists frequently ask when planning, performing, processing, and interpreting MRI perfusion studies in CNS imaging. CONCLUSION: Perfusion MRI is a promising tool in assessing stroke, brain tumors, and ... Full text Link to item Cite

Trends in spinal pain management injections in academic radiology departments.

Journal Article AJNR Am J Neuroradiol · January 2013 BACKGROUND AND PURPOSE: There is a paucity of information present in the current literature with regard to the role of SPMI performance in academic radiology centers. Our aim was to evaluate the current practice patterns for the performance of SPMIs in aca ... Full text Link to item Cite

Perfusion MRI: the five most frequently asked technical questions.

Journal Article AJR Am J Roentgenol · January 2013 OBJECTIVE: This and its companion article address the 10 most frequently asked questions that radiologists face when planning, performing, processing, and interpreting different MR perfusion studies in CNS imaging. CONCLUSION: Perfusion MRI is a promising ... Full text Link to item Cite

Stratified whole genome linkage analysis of Chiari type I malformation implicates known Klippel-Feil syndrome genes as putative disease candidates.

Journal Article PLoS One · 2013 Chiari Type I Malformation (CMI) is characterized by displacement of the cerebellar tonsils below the base of the skull, resulting in significant neurologic morbidity. Although multiple lines of evidence support a genetic contribution to disease, no genes ... Full text Open Access Link to item Cite

SU-D-217BCD-06: Evaluation of Effective Dose during Neuro 3-D Imaging Using a C-Arm Cone-Beam CT System.

Journal Article Med Phys · June 2012 PURPOSE: The purpose of this study was three-fold: 1) to estimate the organ doses and effective dose (ED) for patients undergoing neuro 3D-imaging protocols, 2) to study the effect of beam collimation on ED, and 3) to derive protocol-specific DAP-to-ED con ... Full text Link to item Cite

Radiation dose from 3D rotational X-ray imaging: organ and effective dose with conversion factors.

Journal Article Radiat Prot Dosimetry · June 2012 The purpose of this study was to measure organ doses and the effective dose (ED) using a three-dimensional rotational X-ray (3D-RX) system and to determine the ED conversion factor from the dose area product (DAP) for skull, spine and biliary protocols. A ... Full text Link to item Cite

Neuroradiology: Case 19

Chapter · January 19, 2012 Cite

Neuroradiology: Case 13

Chapter · January 19, 2012 Cite

Neuroradiology: Case5

Chapter · January 19, 2012 Cite

Neuroradiology: Case 23

Chapter · January 19, 2012 Cite

Neuroradiology

Chapter · January 19, 2012 Cite

Stent-assisted coil emboilization of ruptured intracranial aneurysms: A retrospective multicenter review.

Journal Article Surg Neurol Int · 2012 BACKGROUND: The purpose of this study is to retrospectively review our experience with stent-assisted embolization of patients with an acutely ruptured cerebral aneurysm. METHODS: Medical records and imaging were reviewed for 36 patients who underwent sten ... Full text Link to item Cite

Thromboembolic complications after Neuroform stent-assisted treatment of cerebral aneurysms: the Duke Cerebrovascular Center experience in 235 patients with 274 stents.

Journal Article Neurosurgery · August 2011 BACKGROUND: The Neuroform Stent has facilitated the endovascular treatment of wide-necked cerebral aneurysms. It is unknown which factors pose risks of thromboembolic events after stent placement. OBJECTIVE: This series is the largest single-center study r ... Full text Link to item Cite

Endovascular management of inadvertent brachiocephalic arterial catheterization.

Journal Article J Neurosurg · January 2011 OBJECT: Inadvertent catheterization of brachiocephalic arteries (carotid artery, subclavian artery, or vertebral artery) during attempted placement of a central venous catheter can have potentially disastrous complications. While removal of the catheter in ... Full text Link to item Cite

CT angiography of the neck and brain

Journal Article · December 1, 2008 The evolution of multidetector computed tomography (MDCT) has allowed the development and advancement of CT angiography (CTA). While the concept of carotid artery evaluation by CT was introduced by Heinz and others in 1984 [1,2], it has taken recent techno ... Full text Cite

Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15.

Journal Article Am J Med Genet A · December 15, 2006 Chiari type I malformation (CMI; OMIM 118420) is narrowly defined when the tonsils of the cerebellum extend below the foramen magnum, leading to a variety of neurological symptoms. It is widely thought that a small posterior fossa (PF) volume, relative to ... Full text Link to item Cite

A practical approach to CT angiography of the neck and brain.

Journal Article Tech Vasc Interv Radiol · December 2006 Computed tomography angiography (CTA) is a rapidly developing technology with great potential. This is particularly true for evaluating neurovascular disease. Clinical stroke because of atherosclerotic disease of the carotid and vertebral arteries is a com ... Full text Link to item Cite

Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.

Journal Article Environ Health Perspect · October 2006 BACKGROUND: Folate metabolism pathway genes have been examined for association with neural tube defects (NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect. Most studies addressed these genes individually, often wit ... Full text Link to item Cite

CT angiography of the neck and brain

Journal Article · January 1, 2006 The evolution of multidetector computed tomography (MDCT) has allowed the development and advancement of CT angiography (CTA). While the concept of carotid artery evaluation by CT was introduced by Heinz and others in 1984 [1, 2], it has taken recent techn ... Full text Cite

Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10.

Journal Article J Med Genet · December 2005 Neural tube defects (NTDs) are the second most common birth defects (1 in 1000 live births) in the world. Periconceptional maternal folate supplementation reduces NTD risk by 50-70%; however, studies of folate related and other developmental genes in human ... Full text Link to item Cite

Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2.

Journal Article Birth Defects Res A Clin Mol Teratol · November 2005 BACKGROUND: Vitamin A (retinol), in the form of retinoic acid (RA), is essential for normal development of the human embryo. Studies in the mouse and zebrafish have shown that retinol is metabolized in the developing spinal cord and must be maintained in a ... Full text Link to item Cite

SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects.

Journal Article Hum Genet · July 2005 Neural tube defects (NTDs) are common birth defects, occurring in approximately 1/1,000 births; both genetic and environmental factors are implicated. To date, no major genetic risk factors have been identified. Throughout development, cell adhesion molecu ... Full text Link to item Cite

Intra-arterial thrombolytic therapy in peri-coronary angiography ischemic stroke.

Journal Article Stroke · May 2005 BACKGROUND: Intra-arterial thrombolysis (IAT) for peri-coronary angiography (CA) stroke may be safe and efficacious. However, IAT may increase the risk of intracranial hemorrhage (ICH). METHODS: A retrospective study was performed involving 3 university ho ... Full text Link to item Cite

Thrombolytic therapy of acute ischemic stroke: correlation of angiographic recanalization with clinical outcome.

Journal Article AJNR Am J Neuroradiol · April 2005 BACKGROUND AND PURPOSE: The effect of vessel patency, following recombinant tissue plasminogen activator (rtPA) administration, on clinical outcome in acute ischemic stroke (AIS) has been controversial. We studied the effect of recanalization following int ... Link to item Cite

Recurrence risks for neural tube defects in siblings of patients with lipomyelomeningocele.

Journal Article Genet Med · January 2005 PURPOSE: Neural tube defects (NTDs) are a group of widely varying congenital malformations resulting from incomplete or improper fusion of the neural tube during embryonic development. NTDs are traditionally classified by the presence or absence of a layer ... Full text Link to item Cite

Early carotid artery stenting and angioplasty in patients with acute ischemic stroke.

Journal Article Neurosurgery · December 2004 OBJECTIVE: To determine the safety of early percutaneous endovascular carotid angioplasty and stenting (CAS) after an ischemic stroke. METHODS: The neurointerventional database was reviewed for patients who underwent CAS after an acute ischemic stroke in t ... Full text Link to item Cite

TERC is not a major gene in human neural tube defects.

Journal Article Birth Defects Res A Clin Mol Teratol · August 2004 BACKGROUND: Neural tube defects (NTDs) are the second most common birth defects, after congenital heart defects. Telomerase, the reverse transcriptase that maintains telomere DNA, has been shown to be important for neural tube development and bilateral sym ... Full text Link to item Cite

The value of magnetic resonance imaging in the evaluation of fatty filum terminale.

Journal Article Neurosurgery · February 2004 OBJECTIVE: To determine whether there are magnetic resonance imaging (MRI) characteristics of fatty fila that are correlated with neurological deficits, especially in the presence of a normal-level conus medullaris. METHODS: Lumbosacral MRI scans were revi ... Full text Link to item Cite

Review Article: Chiari Type I Malformation with or Without Syringomyelia: Prevalence and Genetics.

Journal Article J Genet Couns · August 2003 Chiari type I malformation has traditionally been defined as a downward herniation of the cerebellar tonsils of ≥5 mm through the foramen magnum and it is likely associated with a volumetrically reduced posterior fossa. Syringomyelia is commonly associated ... Full text Link to item Cite

Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects.

Journal Article Clin Genet · March 2003 Folate supplementation appears to reduce the risk for neural tube defects (NTDs). Methylenetetrahydrofolate reductase (MTHFR) is a candidate gene in the folate metabolism pathway that has been extensively studied in different human populations. We examined ... Full text Link to item Cite

Delayed stenosis following placement of a polyethylene terephthalate endograft in the cervical carotid artery. Report of three cases.

Journal Article J Neurosurg · February 2003 Three patients with carotid artery (CA) pseudoaneurysms were treated using four polyethylene terephthalate endografts (Wallgraft endoprostheses). Two patients received a single graft and one patient with bilateral pseudoaneurysms received two grafts. Compl ... Full text Link to item Cite

T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families.

Journal Article Am J Med Genet · July 1, 2002 We investigated the T locus as a candidate gene in a series of patients and families with lumbosacral myelomeningocele. Single-strand conformation polymorphism (SSCP) analysis was used to identify sequence variation in all 8 exons and in intron 7 of this l ... Full text Link to item Cite

Observer variability in assessing lumbar spinal stenosis severity on magnetic resonance imaging and its relation to cross-sectional spinal canal area.

Journal Article Spine (Phila Pa 1976) · May 15, 2002 STUDY DESIGN: Magnetic resonance image grading of lumbar spinal stenosis severity was analyzed retrospectively using a common clinical format. OBJECTIVE: To assess the interobserver and intraobserver reliability of magnetic resonance image used to grade pa ... Full text Link to item Cite

A novel mutation in the gene encoding noggin is not causative in human neural tube defects.

Journal Article J Neurogenet · 2002 Neural tube defects (NTD) are a common birth defect, with both genetic and environmental contributions to their etiology. In mouse, null mutations in Noggin result in fully-penetrant NTDs. We investigated Noggin for mutations that may predispose to human N ... Link to item Cite

Endodermal cyst of the oculomotor nerve.

Journal Article Neuroradiology · December 2001 Endodermal cysts are rare congenital intracranial lesions. Although histologically benign, they can become symptomatic as a result of mass effect and cause neurological deficits. We report a 30-year-old woman who presented with paresis of her right oculomo ... Full text Link to item Cite

CT fluoroscopy--guided interventional procedures: techniques and radiation dose to radiologists.

Journal Article Radiology · July 2001 PURPOSE: To determine the radiation dose to radiologists who perform computed tomographic (CT) fluoroscopic interventional procedures by using a quick-check method and a low-milliampere technique. MATERIALS AND METHODS: Two hundred twenty CT fluoroscopy--g ... Full text Link to item Cite

Endovascular treatment of cerebral vasospasm.

Journal Article J Vasc Interv Radiol · May 2000 Full text Link to item Cite

A genetic hypothesis for Chiari I malformation with or without syringomyelia.

Journal Article Neurosurg Focus · March 15, 2000 In several reports the authors have suggested occasional familial aggregation of syringomyelia and/or Chiari 1 malformation (CM1). Familial aggregation is one characteristic of traits that have an underlying genetic basis. The authors provide evidence for ... Full text Link to item Cite

Genetic studies in neural tube defects. NTD Collaborative Group.

Journal Article Pediatr Neurosurg · January 2000 Neural tube defects (NTD) are one of the most common birth defects and are caused by both environmental and genetic factors. The approach to identifying the genes predisposing to NTD, through linkage analysis and candidate gene analysis, is reviewed along ... Full text Link to item Cite

Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.

Journal Article Clin Genet · August 1999 Neural tube defects are a common, complex disorder with genetic and environmental components to risk. We investigated the previously reported interaction between homozygosity for the thermolabile variant at the methylenetetrahydrofolate reductase and heter ... Full text Link to item Cite

Iodine-131-metaiodobenzylguanidine uptake in metastatic carcinoid tumor to the orbit.

Journal Article J Nucl Med · April 1998 Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1%-13% of all orbital masses (1). In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit followed by metasta ... Link to item Cite

Neurosyphilis in patients with AIDS.

Journal Article Neuroimaging Clin N Am · May 1997 Syphilis has become much more prevalent because of the dramatic increase in immunocompromised patients. The increase in immunocompromised patients is mainly secondary to AIDS. This article is put forth to refamiliarize the reader with syphilis, specificall ... Link to item Cite

Neuroimaging of AIDS. I. Fungal infections of the central nervous system.

Journal Article Neuroimaging Clin N Am · May 1997 Fungal infections of the central nervous system are quite uncommon and most frequently occur in immunocompromised patients, such as those with AIDS. This article outlines the most common fungal infections that occur in the central nervous system. Even thou ... Link to item Cite

Fungal infections of the central nervous system

Journal Article Neuroimaging Clinics of North America · January 1, 1997 Fungal infections of the central nervous system are quite uncommon and most frequently occur in immunocompromised patients, such as those with AIDS. This article outlines the most common fungal infections that occur in the central nervous system. Even thou ... Cite

The eighth cranial nerve.

Journal Article Top Magn Reson Imaging · June 1996 This review discusses the eighth cranial nerve with emphasis on magnetic resonance imaging (MRI). Normal anatomy of the component nerves as well as pathology that affects it are examined. MRI techniques used to evaluate this area are also presented. ... Link to item Cite

Unusual pattern of enhancement in cryptococcal meningitis: in vivo findings with postmortem correlation.

Journal Article J Comput Assist Tomogr · 1996 Leptomeningeal enhancement on CT and MR imaging studies secondary to cryptococcal meningitis is an uncommon finding. In immunocompromised patients, this meningitis incites only a mild inflammatory reaction and abnormalities are often absent on imaging stud ... Full text Link to item Cite

MRI of papillary meningiomas in children.

Journal Article Pediatr Radiol · November 1995 We report two cases of papillary meningioma in children. The MRI appearance of this special type of meningioma is described for the first time. Both lesions were dura based and associated with cystic components. We review the literature pertaining to this ... Link to item Cite

Cyst of the falciform ligament of the liver.

Journal Article AJR Am J Roentgenol · February 1984 Full text Link to item Cite

An adherence tensiometer for evaluation of burn dressings.

Journal Article Plast Reconstr Surg · February 1980 The measurement of adherence is a function of pulling force and velocity. The machine described measures and records adherence accurately and precisely. In both engineering and clinical laboratory tests, it has shown the ability to be used as standard equi ... Full text Link to item Cite

Burn wound sepsis: effect of delayed treatment with topical chemotherapy on survival.

Journal Article J Trauma · February 1980 Using a standardized laboratory rat model of burn wound sepsis, a regimen of once a day application of Silvadene has been found to be more effective treatment than Sulfamylon or cerium-Silvadene. Delaying treatment following infection resulted in decreased ... Link to item Cite