Eric John Toone
Professor Emeritus of Chemistry
Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry,
traditional enzymology, isothermal titration
microcalorimetry, and the techniques of directed evolution.
Current Appointments & Affiliations
- Professor Emeritus of Chemistry, Chemistry, Trinity College of Arts & Sciences 2018
- Faculty Network Member of The Energy Initiative, Nicholas Institute-Energy Initiative, Initiatives 2012
- Bass Fellow, Chemistry, Trinity College of Arts & Sciences 2003
Contact Information
- 3236 French Science Center, Durham, NC 27708
- Box 90346, Durham, NC 27708-0346
-
eric.toone@duke.edu
(919) 660-1506
-
Breakthrough Energy Ventures
- Background
-
Education, Training, & Certifications
- Ph.D., University of Toronto (Canada) 1988
- M.S., University of Toronto (Canada) 1985
- B.S., University of Guelph (Canada) 1983
-
Previous Appointments & Affiliations
- Professor of Biochemistry, Biochemistry, Basic Science Departments 2011 - 2018
- Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2002 - 2017
- Vice Provost for Innovation and Entrepreneurship, Duke University 2013 - 2017
- Faculty Director of the I & E Certificate Program, Duke Innovation & Entrepreneurship, Initiatives 2015 - 2017
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2002 - 2017
- Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 2010 - 2011
- Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 1996 - 2003
- Anne T. and Robert M. Bass Professor, Chemistry, Trinity College of Arts & Sciences 2002
- Associate Professor, Chemistry, Trinity College of Arts & Sciences 1996 - 2001
- Anne T. and Robert M. Bass Associate Professor, Chemistry, Trinity College of Arts & Sciences 1998 - 2001
- Assistant Professor, Trinity College of Arts & Sciences, Duke University 1993 - 1996
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 1994 - 1996
- Assistant Professor, Chemistry, Trinity College of Arts & Sciences 1990 - 1996
- Recognition
-
In the News
-
OCT 6, 2016 -
SEP 19, 2016 -
JUL 26, 2016 Tech Crunch -
JUL 22, 2016 -
JUN 15, 2016 Duke Magazine -
MAR 25, 2016 The Atlantic -
MAR 2, 2016 The News & Observer -
MAR 1, 2016 -
NOV 2, 2015 -
OCT 2, 2015 -
SEP 1, 2015 -
MAR 12, 2015 The News & Observer -
MAR 11, 2015 -
SEP 25, 2014 WRAL TechWire -
SEP 12, 2014 -
APR 11, 2014
-
-
Awards & Honors
- Expertise
-
Global Scholarship
- Research
-
Selected Grants
- Adjuvant Discovery Program (Option #1) awarded by National Institutes of Health 2014 - 2017
- Adjuvant Discovery Program awarded by National Institutes of Health 2014 - 2017
- LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeae awarded by National Institutes of Health 2011 - 2017
- Structural and Biochemical Studies of LpxC Inhibition awarded by National Institutes of Health 2003 - 2014
- Replacement Equipment Components for an 800 MHz NMR Spectrometer awarded by National Institutes of Health 2010 - 2011
- Purchase of a Q-TOF LC/MS System awarded by National Institutes of Health 2010 - 2011
- NIRT: Hierarchical Bionanomanufacturing awarded by National Science Foundation 2006 - 2010
- Biocatalytic Nanolithography awarded by National Science Foundation 2006 - 2010
- Tissue Transglutaminase in Neurologic Injury awarded by National Institutes of Health 2006 - 2009
- The Evolution of Synthetically Useful Aldolases awarded by National Institutes of Health 2002 - 2006
- Origin and Application of the Cluster Glycoside Effect awarded by National Institutes of Health 1999 - 2006
- Structure and Regulation of hsp90 Chaperones awarded by National Institutes of Health 2005
- Pyruvate Aldolases in Organic Synthesis awarded by National Institutes of Health 1993 - 1998
- Pyruvate Aldolases in Organic Synthesis awarded by National Institutes of Health 1993 - 1998
- Pyruvate Aldolases in Organic Synthesis awarded by National Institutes of Health 1993 - 1998
- Structure and Energetics of Protein-Carbohydrate Complexes awarded by National Institutes of Health 1994 - 1996
- Publications & Artistic Works
-
Selected Publications
-
Books
-
Toone, E. J. Preface. Vol. 78 1, 2011.
-
Toone, E. J. Advances in Enzymology and Related Areas of Molecular Biology. Vol. 78, 2011. https://doi.org/10.1002/9781118105771.Full Text
-
Toone, E. J. Advances in Enzymology and Related Areas of Molecular Biology. Vol. 77, 2011. https://doi.org/10.1002/9780470920541.Full Text
-
Toone, E. J. Advances in Enzymology: And Related Areas of Molecular Biology. Vol. 75, 2010. https://doi.org/10.1002/9780471224464.Full Text
-
Toone, E. J. Advances in enzymology and related areas of molecular biology. Vol. 76, 2008. https://doi.org/10.1002/9780470392881.Full Text
-
-
Academic Articles
-
Martorana, Alessandra M., Elisabete C. C. M. Moura, Paola Sperandeo, Flavia Di Vincenzo, Xiaofei Liang, Eric Toone, Pei Zhou, and Alessandra Polissi. “Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli.” Front Mol Biosci 8 (2021): 758228. https://doi.org/10.3389/fmolb.2021.758228.Full Text Open Access Copy Link to Item
-
Lemaître, Nadine, Xiaofei Liang, Javaria Najeeb, Chul-Jin Lee, Marie Titecat, Emmanuelle Leteurtre, Michel Simonet, Eric J. Toone, Pei Zhou, and Florent Sebbane. “Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.” Mbio 8, no. 4 (July 25, 2017). https://doi.org/10.1128/mBio.00674-17.Full Text Open Access Copy Link to Item
-
Titecat, Marie, Xiaofei Liang, Chul-Jin Lee, Audrey Charlet, Didier Hocquet, Thierry Lambert, Jean-Marie Pagès, et al. “High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.” J Antimicrob Chemother 71, no. 10 (October 2016): 2874–82. https://doi.org/10.1093/jac/dkw210.Full Text Open Access Copy Link to Item
-
Liang, Xiaofei, Ramesh Gopalaswamy, Frank Navas, Eric J. Toone, and Pei Zhou. “A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.” J Org Chem 81, no. 10 (May 20, 2016): 4393–98. https://doi.org/10.1021/acs.joc.6b00589.Full Text Open Access Copy Link to Item
-
Lee, Chul-Jin, Xiaofei Liang, Qinglin Wu, Javaria Najeeb, Jinshi Zhao, Ramesh Gopalaswamy, Marie Titecat, et al. “Drug design from the cryptic inhibitor envelope.” Nat Commun 7 (February 25, 2016): 10638. https://doi.org/10.1038/ncomms10638.Full Text Open Access Copy Link to Item
-
King, Jason R., Carleen M. Bowers, and Eric J. Toone. “Specific binding at the cellulose binding module-cellulose interface observed by force spectroscopy.” Langmuir : The Acs Journal of Surfaces and Colloids 31, no. 11 (March 2015): 3431–40. https://doi.org/10.1021/la504836u.Full Text
-
Sund, J. B., C. P. Causey, S. D. Wolter, C. B. Parker, B. R. Stoner, E. J. Toone, and J. T. Glass. “Diamond surface functionalization with biomimicry - Amine surface tether and thiol moiety for electrochemical sensors.” Applied Surface Science 301 (May 15, 2014): 293–99. https://doi.org/10.1016/j.apsusc.2014.02.067.Full Text
-
Bowers, C. M., M. Zhang, Y. Lyubarskaya, E. J. Toone, C. Tang, and A. A. Shestopalov. “Structural Modifications in Bilayered Molecular Systems Lead to Predictable Changes in Their Electronic Properties.” Advanced Materials Interfaces 1, no. 2 (April 1, 2014). https://doi.org/10.1002/admi.201300109.Full Text
-
Lee, Chul-Jin, Xiaofei Liang, Ramesh Gopalaswamy, Javaria Najeeb, Eugene D. Ark, Eric J. Toone, and Pei Zhou. “Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.” Acs Chem Biol 9, no. 1 (January 17, 2014): 237–46. https://doi.org/10.1021/cb400067g.Full Text Link to Item
-
Sund, J. B., C. P. Causey, S. D. Wolter, C. B. Parker, B. R. Stoner, E. J. Toone, and J. T. Glass. “Diamond surface functionalization with biomimicry - Amine surface tether and thiol moiety for electrochemical sensors.” Applied Surface Science, 2014.
-
Xia, Wenle, David Gooden, Leihua Liu, Sumin Zhao, Erik J. Soderblom, Eric J. Toone, Wayne F. Beyer, Harold Walder, and Neil L. Spector. “Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.” Plos One 9, no. 2 (2014): e88983. https://doi.org/10.1371/journal.pone.0088983.Full Text Link to Item
-
Wang, Y., J. R. King, P. Wu, D. L. Pelzman, D. N. Beratan, and E. J. Toone. “Correction to "Enthalpic Signature of Methonium Desolvation Revealed in a Synthetic Host-Guest System Based on Cucurbit[7]uril".” J Am Chem Soc 135, no. 46 (November 20, 2013): 17650. https://doi.org/10.1021/ja408346j.Full Text Link to Item
-
Liang, Xiaofei, Chul-Jin Lee, Jinshi Zhao, Eric J. Toone, and Pei Zhou. “Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.” J Med Chem 56, no. 17 (September 12, 2013): 6954–66. https://doi.org/10.1021/jm4007774.Full Text Link to Item
-
Grant, Gerald A., Todd Hankinson, Carrie Muh, and Aaron Dumont. “The 62nd Annual Meeting of the Congress of Neurological Surgeons was held in Chicago, Illinois from October 6-10, 2012. Preface.” Neurosurgery 60 Suppl 1 (August 2013): v. https://doi.org/10.1227/NEU.0000000000000006.Full Text Link to Item
-
Toone, Eric, and Han de Winde. “Energy biotechnology in 2013: advanced technology development for breakthroughs in fuels and chemicals production.” Current Opinion in Biotechnology 24, no. 3 (June 2013): 367–68. https://doi.org/10.1016/j.copbio.2013.04.009.Full Text
-
Bowers, Carleen M., David A. Carlson, Monica Rivera, Robert L. Clark, and Eric J. Toone. “Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy.” The Journal of Physical Chemistry. B 117, no. 17 (May 2013): 4755–62. https://doi.org/10.1021/jp309393s.Full Text
-
Wang, Yi, Jason R. King, Pan Wu, Daniel L. Pelzman, David N. Beratan, and Eric J. Toone. “Enthalpic signature of methonium desolvation revealed in a synthetic host-guest system based on cucurbit[7]uril.” Journal of the American Chemical Society 135, no. 16 (April 2013): 6084–91. https://doi.org/10.1021/ja311327v.Full Text
-
Bowers, Carleen M., David A. Carlson, Alexander A. Shestopalov, Robert L. Clark, and Eric J. Toone. “A general and efficient cantilever functionalization technique for AFM molecular recognition studies.” Biopolymers 97, no. 10 (October 2012): 761–65. https://doi.org/10.1002/bip.22061.Full Text
-
Wilfong, Erin M., Yu Du, and Eric J. Toone. “An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1.” Bioorganic & Medicinal Chemistry Letters 22, no. 20 (October 2012): 6521–24. https://doi.org/10.1016/j.bmcl.2012.05.032.Full Text
-
Bowers, Carleen M., Alexander A. Shestopalov, Robert L. Clark, and Eric J. Toone. “Multicomponent patterning of indium tin oxide.” Acs Applied Materials & Interfaces 4, no. 8 (August 2012): 3932–37. https://doi.org/10.1021/am300768f.Full Text
-
Cheriyan, Manoj, Eric J. Toone, and Carol A. Fierke. “Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates.” Biochemistry 51, no. 8 (February 2012): 1658–68. https://doi.org/10.1021/bi201899b.Full Text
-
Coombs, G. S., A. A. Schmitt, C. A. Canning, A. Alok, I. C. C. Low, N. Banerjee, S. Kaur, et al. “Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.” Oncogene 31, no. 2 (January 12, 2012): 213–25. https://doi.org/10.1038/onc.2011.228.Full Text Link to Item
-
Yamazaki, Akihiro, Jin Li, Quan Zeng, Devanshi Khokhani, William C. Hutchins, Angela C. Yost, Eulandria Biddle, Eric J. Toone, Xin Chen, and Ching-Hong Yang. “Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system.” Antimicrobial Agents and Chemotherapy 56, no. 1 (January 2012): 36–43. https://doi.org/10.1128/aac.00732-11.Full Text
-
Bowers, Carleen M., Eric J. Toone, Robert L. Clark, and Alexander A. Shestopalov. “Soft lithographic functionalization and patterning oxide-free silicon and germanium.” Journal of Visualized Experiments : Jove, no. 58 (December 2011): 3478. https://doi.org/10.3791/3478.Full Text
-
Cheriyan, Manoj, Matthew J. Walters, Brian D. Kang, Laura L. Anzaldi, Eric J. Toone, and Carol A. Fierke. “Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate.” Bioorganic & Medicinal Chemistry 19, no. 21 (November 2011): 6447–53. https://doi.org/10.1016/j.bmc.2011.08.056.Full Text
-
Lund, Line Naomi, Trine Christensen, Eric Toone, Gunnar Houen, Arne Staby, and Phaedria Marie St Hilaire. “Exploring variation in binding of Protein A and Protein G to immunoglobulin type G by isothermal titration calorimetry.” Journal of Molecular Recognition : Jmr 24, no. 6 (November 2011): 945–52. https://doi.org/10.1002/jmr.1140.Full Text
-
Wilfong, Erin M., Yuri Kogiso, Sivaramakrishnan Muthukrishnan, Thomas Kowatz, Yu Du, Amber Bowie, James H. Naismith, Christopher M. Hadad, Eric J. Toone, and Terry L. Gustafson. “A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model.” Journal of the American Chemical Society 133, no. 30 (August 2011): 11515–23. https://doi.org/10.1021/ja1098287.Full Text
-
Nguyen, Bidong D., Doreen Cunningham, Xiaofei Liang, Xin Chen, Eric J. Toone, Christian R. H. Raetz, Pei Zhou, and Raphael H. Valdivia. “Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.” Proc Natl Acad Sci U S A 108, no. 25 (June 21, 2011): 10284–89. https://doi.org/10.1073/pnas.1107478108.Full Text Link to Item
-
Morris, Carleen J., Alexander A. Shestopalov, Brian H. Gold, Robert L. Clark, and Eric J. Toone. “Patterning NHS-terminated SAMs on germanium.” Langmuir : The Acs Journal of Surfaces and Colloids 27, no. 10 (May 2011): 6486–89. https://doi.org/10.1021/la200374k.Full Text
-
Shestopalov, Alexander A., Carleen J. Morris, Briana N. Vogen, Amanda Hoertz, Robert L. Clark, and Eric J. Toone. “Soft-lithographic approach to functionalization and nanopatterning oxide-free silicon.” Langmuir : The Acs Journal of Surfaces and Colloids 27, no. 10 (May 2011): 6478–85. https://doi.org/10.1021/la200373g.Full Text
-
Hwang, Sunhee, Allison A. Schmitt, Andrea E. Luteran, Eric J. Toone, and Dewey G. McCafferty. “Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST.” Biochemistry 50, no. 4 (February 2011): 546–57. https://doi.org/10.1021/bi101776t.Full Text
-
Lee, Chul-Jin, Xiaofei Liang, Xin Chen, Daina Zeng, Sang Hoon Joo, Hak Suk Chung, Adam W. Barb, et al. “Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.” Chem Biol 18, no. 1 (January 28, 2011): 38–47. https://doi.org/10.1016/j.chembiol.2010.11.011.Full Text Link to Item
-
Liang, Xiaofei, Chul-Jin Lee, Xin Chen, Hak Suk Chung, Daina Zeng, Christian R. H. Raetz, Yaoxian Li, Pei Zhou, and Eric J. Toone. “Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.” Bioorg Med Chem 19, no. 2 (January 15, 2011): 852–60. https://doi.org/10.1016/j.bmc.2010.12.017.Full Text Link to Item
-
Toone, Eric J. “Advances in enzymology and related areas of molecular biology. Preface.” Advances in Enzymology and Related Areas of Molecular Biology 78 (January 2011): ix–xi.
-
Toone, Eric J. “Bacterial infection remains a leading cause of death in both Western and developing world. Preface.” Advances in Enzymology and Related Areas of Molecular Biology 77 (January 2011): xi–xiii.
-
Colomer, Josep, Allison A. Schmitt, Eric J. Toone, and Anthony R. Means. “Identification and inhibitory properties of a novel Ca(2+)/calmodulin antagonist.” Biochemistry 49, no. 19 (May 2010): 4244–54. https://doi.org/10.1021/bi1001213.Full Text Open Access Copy
-
Shestopalov, Alexander A., Robert L. Clark, and Eric J. Toone. “Catalytic microcontact printing on chemically functionalized H-terminated silicon.” Langmuir : The Acs Journal of Surfaces and Colloids 26, no. 3 (February 2010): 1449–51. https://doi.org/10.1021/la903465f.Full Text Open Access Copy
-
Shestopalov, Alexander A., Robert L. Clark, and Eric J. Toone. “Inkless microcontact printing on SAMs of Boc- and TBS-protected thiols.” Nano Letters 10, no. 1 (January 2010): 43–46. https://doi.org/10.1021/nl902588d.Full Text Open Access Copy
-
Toone, E. J. “Forcing a closer look.” Biopolymers 93, no. 1 (January 1, 2010). https://doi.org/10.1002/bip.21330.Full Text
-
Wilfong, Erin M., Ursala Locklear, and Eric J. Toone. “A single step purification for autolytic zinc proteinases.” Bioorganic & Medicinal Chemistry Letters 20, no. 1 (January 2010): 280–82. https://doi.org/10.1016/j.bmcl.2009.10.114.Full Text
-
Rivera, M., C. Morris, D. Carlson, E. J. Toone, D. G. Cole, and R. L. Clark. “Minimizing tip-sample contact force in automated atomic force microscope based force spectroscopy.” Proceedings of the Asme Design Engineering Technical Conference 6 (December 1, 2009): 731–36. https://doi.org/10.1115/DETC2009-87378.Full Text
-
Gao, Weiping, Wenge Liu, J Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, and Ashutosh Chilkoti. “In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics.” Proc Natl Acad Sci U S A 106, no. 36 (September 8, 2009): 15231–36. https://doi.org/10.1073/pnas.0904378106.Full Text Link to Item
-
Arnold, John J., Yash Choksi, Xin Chen, Atsushi Shimazaki, John Hatten, Eric J. Toone, David L. Epstein, and Pratap Challa. “Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.” J Ocul Pharmacol Ther 25, no. 3 (June 2009): 179–86. https://doi.org/10.1089/jop.2008.0107.Full Text Link to Item
-
Chakrapani, Harinath, Michael D. Bartberger, and Eric J. Toone. “C-nitroso donors of nitric oxide.” The Journal of Organic Chemistry 74, no. 4 (February 2009): 1450–53. https://doi.org/10.1021/jo802517t.Full Text
-
Toone, Eric J. “Advances in enzymology and related areas of molecular biology. Preface.” Advances in Enzymology and Related Areas of Molecular Biology 76 (January 2009): ix–x.
-
Williams, Gavin J., and Jon S. Thorson. “Natural product glycosyltransferases: properties and applications.” Advances in Enzymology and Related Areas of Molecular Biology 76 (January 2009): 55–119. https://doi.org/10.1002/9780470392881.ch2.Full Text
-
Lai, Thung-S, Yusha Liu, Tim Tucker, Kurt R. Daniel, David C. Sane, Eric Toone, James R. Burke, Warren J. Strittmatter, and Charles S. Greenberg. “Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.” Chem Biol 15, no. 9 (September 22, 2008): 969–78. https://doi.org/10.1016/j.chembiol.2008.07.015.Full Text Link to Item
-
Walters, Matthew J., Velupillai Srikannathasan, Andrew R. McEwan, James H. Naismith, Carol A. Fierke, and Eric J. Toone. “Characterization and crystal structure of Escherichia coli KDPGal aldolase.” Bioorganic & Medicinal Chemistry 16, no. 2 (January 2008): 710–20. https://doi.org/10.1016/j.bmc.2007.10.043.Full Text
-
Cheriyan, Manoj, Eric J. Toone, and Carol A. Fierke. “Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates.” Protein Science : A Publication of the Protein Society 16, no. 11 (November 2007): 2368–77. https://doi.org/10.1110/ps.073042907.Full Text
-
Shestopalov, Alexander A., Robert L. Clark, and Eric J. Toone. “Inkless microcontact printing on self-assembled monolayers of fmoc-protected aminothiols.” Journal of the American Chemical Society 129, no. 45 (November 2007): 13818–19. https://doi.org/10.1021/ja076226k.Full Text
-
Snyder, Phillip W., Matthew S. Johannes, Briana N. Vogen, Robert L. Clark, and Eric J. Toone. “Biocatalytic microcontact printing.” The Journal of Organic Chemistry 72, no. 19 (September 2007): 7459–61. https://doi.org/10.1021/jo0711541.Full Text
-
Matsuoka, K., Y. Goshu, Y. Takezawa, T. Mori, J. I. Sakamoto, A. Yamada, T. Onaga, et al. “Practical synthesis of fully protected globotriaose and its glycopolymers.” Carbohydrate Polymers 69, no. 2 (June 1, 2007): 326–35. https://doi.org/10.1016/j.carbpol.2006.10.011.Full Text
-
Snyder, Phillip W., Gwangrog Lee, Piotr E. Marszalek, Robert L. Clark, and Eric J. Toone. “A stochastic, cantilever approach to the evaluation of solution phase thermodynamic quantities.” Proceedings of the National Academy of Sciences of the United States of America 104, no. 8 (February 2007): 2579–84. https://doi.org/10.1073/pnas.0606604104.Full Text
-
Cheryian, M., E. J. Toone, and C. A. Fierke. “Substrate specificity of the electrophilic binding site of KDPG aldolase is altered by mutagenesis (Submitted).” Bioorg. Med. Chem., 2007.
-
Walters, Matthew J., and Eric J. Toone. “Pyruvate aldolases in chiral carbon-carbon bond formation.” Nature Protocols 2, no. 7 (January 2007): 1825–30. https://doi.org/10.1038/nprot.2007.260.Full Text
-
Sidebotham, D., A. Mckee, M. Gillham, and J. H. Levy. “Preface.” Cardiothoracic Critical Care, January 1, 2007, ix–ix. https://doi.org/10.1016/B978-075067572-7.50002-3.Full Text
-
Perry, Jennifer L., Michael R. Goldsmith, T Richard Williams, Kyle P. Radack, Trine Christensen, Justin Gorham, Melissa A. Pasquinelli, Eric J. Toone, David N. Beratan, and John D. Simon. “Binding of warfarin influences the acid-base equilibrium of H242 in sudlow site I of human serum albumin.” Photochemistry and Photobiology 82, no. 5 (September 2006): 1365–69. https://doi.org/10.1562/2006-02-23-ra-811.Full Text
-
Fullerton, Stephen W. B., Jennifer S. Griffiths, Alexandra B. Merkel, Manoj Cheriyan, Nathan J. Wymer, Michael J. Hutchins, Carol A. Fierke, Eric J. Toone, and James H. Naismith. “Mechanism of the Class I KDPG aldolase.” Bioorganic & Medicinal Chemistry 14, no. 9 (May 2006): 3002–10. https://doi.org/10.1016/j.bmc.2005.12.022.Full Text
-
Pamula, V. K., V. Srinivasan, H. Chakrapani, R. B. Fair, and E. J. Toone. “A droplet-based lab-on-a-chip for colorimetric detection of nitroaromatic explosives.” Proceedings of the Ieee International Conference on Micro Electro Mechanical Systems (Mems), October 25, 2005, 722–25. https://doi.org/10.1109/MEMSYS.2005.1454031.Full Text
-
Zhao, Yi-Lei, Patrick R. McCarren, K. N. Houk, Bo Yoon Choi, and Eric J. Toone. “Nitrosonium-catalyzed decomposition of s-nitrosothiols in solution: a theoretical and experimental study.” Journal of the American Chemical Society 127, no. 31 (August 2005): 10917–24. https://doi.org/10.1021/ja050018f.Full Text
-
Winter-Vann, Ann M., Rudi A. Baron, Waihay Wong, June dela Cruz, John D. York, David M. Gooden, Martin O. Bergo, Stephen G. Young, Eric J. Toone, and Patrick J. Casey. “A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.” Proc Natl Acad Sci U S A 102, no. 12 (March 22, 2005): 4336–41. https://doi.org/10.1073/pnas.0408107102.Full Text Link to Item
-
Mori, T., K. Hatano, K. Matsuoka, Y. Esumi, E. J. Toone, and D. Terunuma. “Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose.” Tetrahedron 61, no. 11 (March 14, 2005): 2751–60. https://doi.org/10.1016/j.tet.2005.01.090.Full Text
-
Gooden, David M., Harinath Chakrapani, and Eric J. Toone. “C-nitroso compounds: synthesis, physicochemical properties and biological activities.” Current Topics in Medicinal Chemistry 5, no. 7 (January 2005): 687–705. https://doi.org/10.2174/1568026054679353.Full Text
-
Snyder, P. W., G. Lee, P. E. Marszalke, R. L. Clark, and E. J. Toone. “Quantitative determination of analytes by force microscopy (Submitted).” J. Am. Chem. Soc., 2005.
-
Griffiths, Jennifer S., Manoj Cheriyan, Jayme B. Corbell, Luka Pocivavsek, Carol A. Fierke, and Eric J. Toone. “A bacterial selection for the directed evolution of pyruvate aldolases.” Bioorganic & Medicinal Chemistry 12, no. 15 (August 2004): 4067–74. https://doi.org/10.1016/j.bmc.2004.05.034.Full Text
-
Perry, J. L., T. Christensen, M. R. Goldsmith, E. J. Toone, D. N. Beratan, and J. D. Simon. “Binding of ochratoxin a to human serum albumin stabilized by a protein-ligand ion pair.” Journal of Physical Chemistry B 107, no. 31 (August 7, 2003): 7884–88. https://doi.org/10.1021/jp034783x.Full Text
-
Debenham, Sheryl D., Phillip W. Snyder, and Eric J. Toone. “Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands.” The Journal of Organic Chemistry 68, no. 15 (July 2003): 5805–11. https://doi.org/10.1021/jo0207271.Full Text
-
Christensen, Trine, David M. Gooden, Joyce E. Kung, and Eric J. Toone. “Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction.” Journal of the American Chemical Society 125, no. 24 (June 2003): 7357–66. https://doi.org/10.1021/ja021240c.Full Text
-
Houk, K. N., Bruce N. Hietbrink, Michael D. Bartberger, Patrick R. McCarren, Bo Yoon Choi, Robert D. Voyksner, Jonathan S. Stamler, and Eric J. Toone. “Nitroxyl disulfides, novel intermediates in transnitrosation reactions.” Journal of the American Chemical Society 125, no. 23 (June 2003): 6972–76. https://doi.org/10.1021/ja029655l.Full Text
-
Christensen, Trine, and Eric J. Toone. “Calorimetric evaluation of protein-carbohydrate affinities.” Methods in Enzymology 362 (January 2003): 486–504. https://doi.org/10.1016/s0076-6879(03)01032-2.Full Text
-
Lundquist, J. J., B. M. Kiburz, J. K. Wu, K. D. Gibbs, and E. J. Toone. “Towards high affinity carbohydrate-binding proteins: Directed evolution of murine galectin-3.” Canadian Journal of Chemistry 80, no. 8 (December 3, 2002): 999–1009. https://doi.org/10.1139/v02-086.Full Text
-
Choi, B. Y., R. D. Voyksner, and E. J. Toone. “Analysis of S-nitrosothiol decomposition.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, December 1, 2002, 799–800.
-
Stamler, Jonathan S., and Eric J. Toone. “The decomposition of thionitrites.” Current Opinion in Chemical Biology 6, no. 6 (December 2002): 779–85. https://doi.org/10.1016/s1367-5931(02)00383-6.Full Text
-
Griffiths, Jennifer S., Nathan J. Wymer, Eugenia Njolito, S. Niranjanakumari, Carol A. Fierke, and Eric J. Toone. “Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase.” Bioorganic & Medicinal Chemistry 10, no. 3 (March 2002): 545–50. https://doi.org/10.1016/s0968-0896(01)00307-8.Full Text
-
Lundquist, Joseph J., and Eric J. Toone. “The cluster glycoside effect.” Chemical Reviews 102, no. 2 (February 2002): 555–78. https://doi.org/10.1021/cr000418f.Full Text
-
Bartberger, M. D., J. D. Mannion, S. C. Powell, J. S. Stamler, K. N. Houk, and E. J. Toone. “S-N dissociation energies of S-nitrosothiols: on the origins of nitrosothiol decomposition rates.” Journal of the American Chemical Society 123, no. 36 (September 2001): 8868–69. https://doi.org/10.1021/ja0109390.Full Text
-
Moya, M. P., A. J. Gow, T. J. McMahon, E. J. Toone, I. M. Cheifetz, R. N. Goldberg, and J. S. Stamler. “S-nitrosothiol repletion by an inhaled gas regulates pulmonary function.” Proc Natl Acad Sci U S A 98, no. 10 (May 8, 2001): 5792–97. https://doi.org/10.1073/pnas.091109498.Full Text Link to Item
-
DiTusa, C. A., K. A. McCall, T. Christensen, M. Mahapatro, C. A. Fierke, and E. J. Toone. “Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants.” Biochemistry 40, no. 18 (May 2001): 5345–51. https://doi.org/10.1021/bi0017327.Full Text
-
DiTusa, C. A., T. Christensen, K. A. McCall, C. A. Fierke, and E. J. Toone. “Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase.” Biochemistry 40, no. 18 (May 2001): 5338–44. https://doi.org/10.1021/bi001731e.Full Text
-
Ditusa, C. A., C. A. Fierke, and E. J. Toone. “Thermodynamics of Metal Ion Bonding. II. Metal Ion Binding by Mutated Carbonic Anhydrases.” Biochemistry 40, no. 18 (2001): 5345–51.
-
Wymer, N., L. V. Buchanan, D. Henderson, N. Mehta, C. H. Botting, L. Pocivavsek, C. A. Fierke, E. J. Toone, and J. H. Naismith. “Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.” Structure (London, England : 1993) 9, no. 1 (January 2001): 1–9. https://doi.org/10.1016/s0969-2126(00)00555-4.Full Text
-
Lundquist, J. J., S. D. Debenham, and E. J. Toone. “Multivalency effects in protein--carbohydrate interaction: the binding of the Shiga-like toxin 1 binding subunit to multivalent C-linked glycopeptides.” The Journal of Organic Chemistry 65, no. 24 (December 2000): 8245–50. https://doi.org/10.1021/jo000943e.Full Text
-
Bartberger, M. D., K. N. Houk, S. C. Powell, J. D. Mannion, K. Y. Lo, J. S. Stamler, and E. J. Toone. “Theory, spectroscopy, and crystallographic analysis of S-nitrosothiols: Conformational distribution dictates spectroscopic behavior [7].” Journal of the American Chemical Society 122, no. 24 (June 21, 2000): 5889–90. https://doi.org/10.1021/ja994476y.Full Text
-
Trzaska, S. M., E. J. Toone, and A. L. Crumbliss. “Microcalorimetric determination of thermodynamic parameters for ionophore-siderophore host-guest complex formation.” Inorganic Chemistry 39, no. 6 (March 2000): 1071–75. https://doi.org/10.1021/ic9908571.Full Text
-
Debenham, S. D., and E. J. Toone. “Regioselective reduction of 4,6-O-benzylidenes using triethylsilane and BF3.Et2O.” Tetrahedron Asymmetry 11, no. 2 (February 11, 2000): 385–87. https://doi.org/10.1016/S0957-4166(99)00584-4.Full Text
-
Wymer, N., and E. J. Toone. “Enzyme-catalyzed synthesis of carbohydrates.” Current Opinion in Chemical Biology 4, no. 1 (February 2000): 110–19. https://doi.org/10.1016/s1367-5931(99)00061-7.Full Text
-
Corbell, J. B., J. J. Lundquist, and E. J. Toone. “A comparison of biological and calorimetric analyses of multivalent glycodendrimer ligands for concanavalin A.” Tetrahedron Asymmetry 11, no. 1 (January 28, 2000): 95–111. https://doi.org/10.1016/S0957-4166(99)00589-3.Full Text
-
Bartberger, M. D., K. N. Houk, S. Powell, J. Mannion, K. Y. K. Lo, J. S. Stamler, and E. J. Toone. “Nuclear Magnetic Resonance and Visible Spectroscopy of S-Nitrosothiols. Conformational Distribution Dictates Spectroscopic Behavior.” J. Am. Chem. Soc. 122 (2000): 5889–90.
-
Corbell, J. B., J. J. Lundquist, and E. J. Toone. “Biological and Calorimetric Analysis of Multivalent Glycodendrimers Ligands for Concanavalin A.” Tetrahedron Asymm. 11 (2000): 95–111.
-
Debenham, S., and E. J. Toone. “A Facile Method for the Reductive Deprotection of Carbohydrate Benzylidene Protecting Groups.” Tetrahedron Asymm., 2000, 385–87.
-
Lundquist, J. J., S. D. Debenham, and E. J. Toone. “Calorimetric and Biological Evaluation of Shigalike Toxin1 Binding to Multivalent C-Linked Glycopeptides.” J. Org. Chem. 65 (2000): 8245–50.
-
Wymer, N., and E. J. Toone. “Enzymatic Carbohydrate Synthesis.” Current Opinion in Chemical Biology 4 (2000): 110–19.
-
Debenham, S. D., J. Cossrow, and E. J. Toone. “Synthesis of α- and β-carbon-linked serine analogues of the P(k) trisaccharide.” Journal of Organic Chemistry 64, no. 25 (December 10, 1999): 9153–63. https://doi.org/10.1021/jo991096m.Full Text
-
Dimick, S. M., S. C. Powell, S. A. McMahon, D. N. Moothoo, J. H. Naismith, and E. J. Toone. “On the meaning of affinity: Cluster glycoside effects and concanavalin A.” Journal of the American Chemical Society 121, no. 44 (November 10, 1999): 10286–96. https://doi.org/10.1021/ja991729e.Full Text
-
Buchanan, L. V., N. Mehta, L. Pocivavsek, S. Niranjanakumari, E. J. Toone, and J. H. Naismith. “Initiating a structural study of 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.” Acta Crystallographica. Section D, Biological Crystallography 55, no. Pt 11 (November 1999): 1946–48. https://doi.org/10.1107/s0907444999011166.Full Text
-
Wymer, N., L. V. Buchanan, N. Mehta, L. Pocivavsek, S. Nirjanakumari, E. J. Toone, and J. H. Naismith. “Initiating a Structural Study of KDPG Aldolase from Escherichia coli.” Acta Cryst. D55 (1999): 1946–48.
-
Cotterill, I. C., D. P. Henderson, M. C. Shelton, and E. J. Toone. “The synthetic utility of KDPGal aldolase.” Journal of Molecular Catalysis B Enzymatic 5, no. 1–4 (September 15, 1998): 103–11. https://doi.org/10.1016/S1381-1177(98)00087-3.Full Text
-
Moothoo, D. N., S. A. McMahon, S. M. Dimick, E. J. Toone, and J. H. Naismith. “Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis.” Acta Crystallographica. Section D, Biological Crystallography 54, no. Pt 5 (September 1998): 1023–25. https://doi.org/10.1107/s0907444998003965.Full Text
-
Cotterill, I. C., M. C. Shelton, D. E. W. Machemer, D. P. Henderson, and E. J. Toone. “Effect of phosphorylation on the reaction rate of unnatural electrophiles with 2-keto-3-deoxy-6-phosphogluconate aldolase.” Journal of the Chemical Society Perkin Transactions 1, no. 7 (April 7, 1998): 1335–41. https://doi.org/10.1039/a706764j.Full Text
-
Henderson, D. P., I. C. Cotterill, M. C. Shelton, and E. J. Toone. “2-Keto-3-deoxy-6-phosphogalactonate Aldolase as a Catalyst for Stereocontrolled Carbon-Carbon Bond Formation.” Journal of Organic Chemistry 63, no. 4 (February 20, 1998): 906–7. https://doi.org/10.1021/jo9718814.Full Text
-
Cotterill, I. C., M. C. Shelton, D. F. Henderson, and E. J. Toone. “Phosphate as Both a Activating and Protecting Group in Aldolase-Based Syntheses.” J. Chem. Soc. Perkin Trans. I 7 (1998): 1335–42.
-
Henderson, Darla P., Michael C. Shelton, Ian C. Cotterill, and Eric J. Toone. “Stereospecific Preparation of the N-Terminal Amino Acid Moiety of Nikkomycins K(X) and K(Z) via a Multiple Enzyme Synthesis.” The Journal of Organic Chemistry 62, no. 23 (November 1997): 7910–11. https://doi.org/10.1021/jo971549s.Full Text
-
Stamler, J. S., E. J. Toone, S. A. Lipton, and N. J. Sucher. “(S)NO signals: translocation, regulation, and a consensus motif.” Neuron 18, no. 5 (May 1997): 691–96. https://doi.org/10.1016/s0896-6273(00)80310-4.Full Text
-
Harris, S. L., L. Craig, J. S. Mehroke, M. Rashed, M. B. Zwick, K. Kenar, E. J. Toone, et al. “Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies.” Proceedings of the National Academy of Sciences of the United States of America 94, no. 6 (March 1997): 2454–59. https://doi.org/10.1073/pnas.94.6.2454.Full Text
-
Debenham, S. D., J. S. Debenham, M. J. Burk, and E. J. Toone. “Synthesis of carbon-linked glycopeptides through catalytic asymmetric hydrogenation.” Journal of the American Chemical Society 119, no. 41 (January 1, 1997): 9897–98. https://doi.org/10.1021/ja971324z.Full Text
-
Oas, T. G., and E. J. Toone. “Thermodynamic Solvent Isotope Effects and Molecular Hydorphobicity.” Adv. Biophys. Chem. 6 (1997): 1–52.
-
Stamler, J. S., E. J. Toone, S. Lipton, and N. Sucher. “(S)NO Signals: A Consensus Motif.” Neuron 18 (1997): 691.
-
Gupta, D., S. Oscarson, T. S. Raju, P. Stanley, E. J. Toone, and C. F. Brewer. “A comparison of the fine saccharide-binding specificity of Dioclea grandiflora lectin and concanavalin A.” European Journal of Biochemistry 242, no. 2 (December 1996): 320–26. https://doi.org/10.1111/j.1432-1033.1996.0320r.x.Full Text
-
Shelton, M. C., I. C. Cotterill, S. T. A. Novak, R. M. Poonawala, S. Sudarshan, and E. J. Toone. “2-keto-3-deoxy-6-phosphogluconate aldolases as catalysts for stereocontrolled carbon-carbon bond formation.” Journal of the American Chemical Society 118, no. 9 (December 1, 1996).
-
Chervenak, M. C., and E. J. Toone. “Analysis of the binding specificities of oligomannoside-binding proteins using methylated monosaccharides.” Bioorganic & Medicinal Chemistry 4, no. 11 (November 1996): 1963–77. https://doi.org/10.1016/s0968-0896(96)00178-2.Full Text
-
Weatherman, R. V., K. H. Mortell, M. Chervenak, L. L. Kiessling, and E. J. Toone. “Specificity of C-glycoside complexation by mannose/glucose specific lectins.” Biochemistry 35, no. 11 (March 1996): 3619–24. https://doi.org/10.1021/bi951916z.Full Text
-
Clark, C., D. Bast, A. M. Sharp, P. M. St Hilaire, R. Agha, P. E. Stein, E. J. Toone, R. J. Read, and J. L. Brunton. “Phenylalanine 30 plays an important role in receptor binding of verotoxin-1.” Molecular Microbiology 19, no. 4 (February 1996): 891–99. https://doi.org/10.1046/j.1365-2958.1996.427962.x.Full Text
-
Shelton, M. C., I. C. Cotterill, S. T. A. Novak, R. M. Poonawala, S. Sudarshan, and E. J. Toone. “Keto-3-Deoxy-6-Phosphogluconate Aldolases as Catalysts for Stereocontrolled Carbon-Carbon Bond Formation.” J. Am. Chem. Soc. 118 (1996): 2117–25.
-
Shelton, M. C., I. C. Cotterill, S. T. A. Novak, R. M. Poonawala, S. Sudarshan, and E. J. Toone. “2-Keto-3-deoxy-6-phosphogluconate aldolases as catalysts for stereocontrolled carbon-carbon bond formation.” Journal of the American Chemical Society 118, no. 9 (January 1, 1996): 2117–25. https://doi.org/10.1021/ja952596+.Full Text
-
Chervenak, M. C., and E. J. Toone. “Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities.” Biochemistry 34, no. 16 (April 1995): 5685–95. https://doi.org/10.1021/bi00016a045.Full Text
-
Chervenak, M. C., and E. J. Toone. “Corrections. Calorimetric Analysis of the Binding of Lectins with Overlapping Carbohydrate-Binding Ligand Specificities (Biochemistry (1995) 34(16) (5685–5695) (10.1021/bi00016a045)).” Biochemistry 34, no. 24 (January 1, 1995): 7966. https://doi.org/10.1021/bi00024a022.Full Text
-
Isbister, B. D., P. M. S. Hilaire, and E. J. Toone. “Spatial Organization versus Total Surface Area as a Predictor of Protein Hydrophobicity. The Hydrophobicity of the Concanavalin A Binding Site†.” Journal of the American Chemical Society 117, no. 51 (January 1, 1995): 12877–78. https://doi.org/10.1021/ja00156a033.Full Text
-
Shelton, M. C., and E. J. Toone. “Differential dye-ligand chromatography as a general purification protocol for 2-keto-3-deoxy-6-phosphogluconate aldolases.” Tetrahedron: Asymmetry 6, no. 1 (January 1, 1995): 207–11. https://doi.org/10.1016/0957-4166(94)00376-M.Full Text
-
St Hilaire, P. M., M. K. Boyd, and E. J. Toone. “Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor.” Biochemistry 33, no. 48 (December 1994): 14452–63. https://doi.org/10.1021/bi00252a011.Full Text
-
Chervenak, M. C., and E. J. Toone. “A Direct Measure of the Contribution of Solvent Reorganization to the Enthalpy of Binding.” Journal of the American Chemical Society 116, no. 23 (November 1, 1994): 10533–39. https://doi.org/10.1021/ja00102a021.Full Text
-
Simon, S. A., E. A. Disalvo, K. Gawrisch, V. Borovyagin, E. Toone, S. S. Schiffman, D. Needham, and T. J. McIntosh. “Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid.” Biophys J 66, no. 6 (June 1994): 1943–58. https://doi.org/10.1016/S0006-3495(94)80988-9.Full Text Link to Item
-
Simon, S. A., E. A. Sisalvo, K. Gawrisch, V. Borovyagin, E. J. Toone, S. S. Schiffman, D. Needham, and T. J. McIntosh. “A Molecular Mechanism for Increasing Adhesion Between Neutral Lipid Membranes: Interbilayer Bridges Formed by Tannic Acid.” Biophys. J. 66 (1994): 1943–57.
-
Toone, E. J. “Structure and energetics of protein-carbohydrate complexes.” Current Opinion in Structural Biology 4, no. 5 (January 1, 1994): 719–28. https://doi.org/10.1016/S0959-440X(94)90170-8.Full Text
-
Williams, B. A., and E. J. Toone. “Calorimetric Evaluation of Enzyme Kinetic Parameters.” Journal of Organic Chemistry 58, no. 13 (January 1, 1993): 3507–10. https://doi.org/10.1021/jo00065a010.Full Text
-
Williams, B. A., M. C. Chervenak, and E. J. Toone. “Energetics of lectin-carbohydrate binding. A microcalorimetric investigation of concanavalin A-oligomannoside complexation.” The Journal of Biological Chemistry 267, no. 32 (November 1992): 22907–11. https://doi.org/10.1016/s0021-9258(18)50033-8.Full Text
-
Allen, S. T., G. R. Heintzelman, and E. J. Toone. “Pyruvate Aldolases as Reagents for Stereospecific Aldol Condensation.” Journal of Organic Chemistry 57, no. 2 (January 1, 1992): 426–27. https://doi.org/10.1021/jo00028a005.Full Text
-
Hamakawa, Y., and H. Matsunami. “Preface.” Solar Energy Materials 23, no. 2–4 (December 1, 1991): 3. https://doi.org/10.1016/0165-1633(91)90111-W.Full Text
-
Toone, E. J., E. S. Simon, and G. M. Whitesides. “Enzymatic Synthesis of Uridine 5′-Diphosphoglucuronic Acid on a Gram Scale.” Journal of Organic Chemistry 56, no. 19 (September 1, 1991): 5603–6. https://doi.org/10.1021/jo00019a026.Full Text
-
Toone, E. J., and J. B. Jones. “Enzymes in organic synthesis 49. Resolutions of racemic monocyclic esters with pig liver esterase.” Tetrahedron: Asymmetry 2, no. 3 (January 1, 1991): 207–22. https://doi.org/10.1016/S0957-4166(00)82360-5.Full Text
-
Toone, E. J., and J. B. Jones. “Enzymes in Organic Synthesis. 50. Probing the Dimensions of the Large Hydrophobic Binding Region of the Active Site of Pig Liver Esterase Using Substituted Aryl Malonate Substrates.” Tetrahedron Asym. 2 (1991): 207.
-
Toone, E. J., and J. B. Jones. “Enzymes in organic synthesis 50. Probing the dimensions of the large hydrophobic binding region of the active site of pig liver esterase using substituted aryl malonate substrates.” Tetrahedron: Asymmetry 2, no. 10 (January 1, 1991): 1041–52. https://doi.org/10.1016/S0957-4166(00)86155-8.Full Text
-
Osten, C. H. von der, C. Gioannetti, C. Barbas, R. L. Pederson, Y. F. Wang, C. H. Wong, A. Ozaki, E. Toone, G. M. Whitesides, and A. J. Sinskey. “Molecular cloning of aldolases for synthetic applications.” Annals of the New York Academy of Sciences 613 (January 1990): 771–75. https://doi.org/10.1111/j.1749-6632.1990.tb18262.x.Full Text
-
Ozaki, A., E. J. Toone, G. M. Whitesides, C. H. vonderOsten, and A. J. Sinskey. “Overproduction and Substrate Specificity of a Bacterial Fuculose-1-phosphate Aldolase: A New Enzymatic Catalyst for Stereocontrolled Aldol Condensation.” Journal of the American Chemical Society 112, no. 12 (January 1, 1990): 4970–71. https://doi.org/10.1021/ja00168a058.Full Text
-
Toone, E. J., M. J. Werth, and J. Bryan Jones. “Active-Site Model for Interpreting and Predicting the Specificity of Pig Liver Esterase.” Journal of the American Chemical Society 112, no. 12 (January 1, 1990): 4946–52. https://doi.org/10.1021/ja00168a047.Full Text
-
Toone, E. “Computer Software Reviews.” Journal of the American Chemical Society 111, no. 5 (March 1, 1989): 1942–43. https://doi.org/10.1021/ja00187a600.Full Text
-
Simon, E. S., E. J. Toone, G. Ostroff, M. D. Bednarski, and G. M. Whitesides. “Preparation of cytidine 5'-monophospho-N-acetylneuraminic acid and uridine 5'-diphosphoglucuronic acid; syntheses of alpha-2, 6-sialyllactosamine, alpha-2, 6-sialyllactose, and hyaluronic acid.” Methods in Enzymology 179 (January 1989): 275–87. https://doi.org/10.1016/0076-6879(89)79129-1.Full Text
-
Toone, E. J., E. S. Simon, M. D. Bednarski, and G. M. Whitesides. “Enzyme-catalyzed synthesis of carbohydrates.” Tetrahedron 45, no. 17 (January 1, 1989): 5365–5422. https://doi.org/10.1016/S0040-4020(01)89487-4.Full Text
-
Lam, L. K. P., C. M. Brown, L. Lym, E. J. Toone, J. B. Jones, and B. D. Jeso. “Enzymes in organic synthesis. 42. Investigation of the effects of the isozymal composition of pig liver esterase on its stereoselectivity in preparative-scale ester hydrolyses of asymmetric synthetic value.” Journal of the American Chemical Society 110, no. 13 (January 1, 1988): 4409–11. https://doi.org/10.1021/ja00221a049.Full Text
-
Lemiere, G. L., R. A. Dommisse, J. A. Lepoivre, F. C. Alderweireldt, H. Hiemstra, H. Wynberg, J. B. Jones, and E. J. Toone. “Determination of the Absolute Configuration of Six-Membered-Ring Ketones by 13C NMR.” Journal of the American Chemical Society 109, no. 5 (March 1, 1987): 1363–70. https://doi.org/10.1021/ja00239a013.Full Text
-
Toone, E. J., and J. B. Jones. “Enzymes in organic synthesis. 40. Evaluation of the enantioselectivity of the pig liver esterase catalyzed hydrolyses of racemic piperidine carboxylic acid esters.” Canadian Journal of Chemistry 65, no. 12 (January 1, 1987): 2722–26. https://doi.org/10.1139/v87-452.Full Text
-
Burton, R. M., and B. Obel. “Preface.” Technovation 5, no. 1–3 (January 1, 1986): 7. https://doi.org/10.1016/0166-4972(86)90039-8.Full Text
-
BUNCE, N. J., and E. J. TOONE. “PHOTOCHEMISTRY OF BENZOPHENONE IN ACIDIFIED METHANOL.” Journal of Chemical Research S, no. 5 (January 1, 1983): 115–115.Link to Item
-
Bunce, N. J., C. T. Deschutter, and E. J. Toone. “Photolysis of some ortho-methylated monochlorobiphenyls.” Journal of the Chemical Society, Perkin Transactions 2, no. 6 (January 1, 1983): 859–61. https://doi.org/10.1039/P29830000859.Full Text
-
-
Book Sections
-
Broder, J. “Preface,” xi–xii, 2011. https://doi.org/10.1016/B978-1-4160-6113-7.10024-9.Full Text
-
Burkhalter, N. F., S. M. Dimick, and E. J. Toone. “Protein-carbohydrate interaction: Fundamental considerations.” In Carbohydrates in Chemistry and Biology, 2–4:863–914, 2008. https://doi.org/10.1002/9783527618255.ch31.Full Text
-
Dodds, D. R., and P. E. J. Toone. “Preface,” 2:xiii, 1994. https://doi.org/10.1016/0968-0896(94)80002-2.Full Text
-
-
Other Articles
-
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.
