Overview
Dr. Crosby received her PhD in Immunology from the University of Pennsylvania where she used models of chronic infection to understand how the immune system causes damage to healthy tissue. She arrived at Duke for a postdoctoral fellowship where she applied this knowledge to test new therapies that bypass this immune system regulation to treat breast cancer. Dr. Crosby remained at Duke to start her own research program in 2021.
Current Appointments & Affiliations
Assistant Professor in Surgery
·
2021 - Present
Surgery, Surgical Sciences,
Surgery
Assistant Professor in Molecular Genetics and Microbiology
·
2023 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Assistant Professor in Integrative Immunobiology
·
2024 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2023 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity.
Journal Article Sci Immunol · December 19, 2025 Tumor antigen vaccination represents an appealing approach for cancer but has failed to materialize as oncologic standard of care. To understand long-term vaccine efficacy, we conducted a retrospective analysis of patients with human epidermal growth recep ... Full text Link to item CiteAbstract B074: scRNA-seq from FFPE tissue resolves the tumor microenvironment of intraductal papillary mucinous neoplasms
Conference Cancer Research · September 28, 2025 AbstractIntraductal papillary mucinous neoplasms (IPMN) are precancerous cysts representing the only radiographically identifiable precursor to pa ... Full text CiteAbstract A009: Characterizing the pre-metastatic liver in PDAC patients using scRNA-seq of FFPE tissue
Conference Cancer Research · September 28, 2025 AbstractPancreatic ductal adenocarcinoma (PDAC) remains an essentially incurable disease. Even among patients considered for curative-intent surge ... Full text CiteRecent Grants
Advanced Immunobiology Traning Program for Surgeons
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Allergy and Infectious Diseases · 2019 - 2029Targeted vaccination against common resistance genes and neoepitope mutation drivers to treat and prevent endocrine-resistant ER+ Breast Cancer
ResearchCo Investigator · Awarded by Department of Defense · 2024 - 2027Spatial multiomic evaluation of clinical responders with advanced triple negative breast cancer from KEYNOTE-890 to validate a published CXCR3 gene signature
ResearchPrincipal Investigator · Awarded by Department of Defense · 2023 - 2027View All Grants
Education, Training & Certifications
University of Pennsylvania ·
2014
Ph.D.
Bucknell University ·
2009
B.S.