Erin V Shea

Journal Article Pediatric Cardiology · January 1, 2024 Patients with a single ventricle heart who had Fontan palliation (S/P Fontan) are at increased risk for acquired morbidity. Insulin resistance (IR) is a predictor of cardiac morbidity and mortality. A single-center, cross-sectional study using S/P Fontan a ... Full text Cite

Pediatric Heart Transplant Rejection After COVID-19 Infection.

Journal Article Transplant Proc · October 2023 BACKGROUND: Infections have been associated with rejection episodes in solid organ transplant recipients. We report an association between COVID-19 infection and heart transplant (HT) rejection. CASE DESCRIPTION: The patient was 14 years old and 6.5 years ... Full text Link to item Cite

Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.

Journal Article Drug Metab Dispos · January 2013 Studies in microsomal and reconstituted systems have shown that the presence of one cytochrome P450 isoform can significantly influence the catalytic activity of another isoform. In this study, we assessed whether CYP2E1 could influence the catalytic activ ... Full text Link to item Cite

Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions.

Journal Article Biochemistry · May 17, 2011 Cytochrome P450 (CYP or P450)-mediated drug metabolism requires the interaction of P450s with their redox partner, cytochrome P450 reductase (CPR). In this work, we have investigated the role of P450 hydrophobic residues in complex formation with CPR and u ... Full text Link to item Cite