Current Appointments & Affiliations
Assistant Professor in Dermatology
·
2021 - Present
Dermatology,
Clinical Science Departments
Recent Publications
SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy.
Journal Article Cancer Res · August 3, 2022 UNLABELLED: The type I interferon response plays a pivotal role in promoting antitumor immune activity in response to radiotherapy. The identification of approaches to boost the radiation-induced type I interferon response could help improve the efficacy o ... Full text Link to item CiteATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation.
Journal Article J Clin Invest · February 1, 2021 Novel approaches are needed to boost the efficacy of immune checkpoint blockade (ICB) therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA double-stranded breaks (DSBs) and coordinating their repair. Recent data indicate ... Full text Link to item CiteInhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Journal Article Nature · December 2020 Despite its success in achieving the long-term survival of 10-30% of treated individuals, immune therapy is still ineffective for most patients with cancer1,2. Many efforts are therefore underway to identify new approaches that enhance such immune 'checkpo ... Full text Link to item CiteRecent Grants
Novel roles of PCSK9 in regulating the tumor immune microenvironment during radiotherapy
ResearchCo-Principal Investigator · Awarded by National Cancer Institute · 2022 - 2027Targeting ATM to boost systemic effects of radiotherapy and immunotherapy
ResearchCo-Principal Investigator · Awarded by National Cancer Institute · 2021 - 2026Necroptotic genes in cancer cellular response to radiation
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2024View All Grants
Education, Training & Certifications
Sun Yat Sen University (China) ·
2001
Ph.D.
Sichuan University (China) ·
1987
B.S.