Fang Li | Scholars@Duke

Fang Li
Assistant Professor in Dermatology

Current Appointments & Affiliations

Assistant Professor in Dermatology, Dermatology, Clinical Science Departments 2011

Contact Information

905 South Lasalle St, 3048 GSRB1, Durham, NC 27710
Box 3135 Med Ctr, Durham, NC 27710
fang.li@duke.edu (919) 681-5461

Background
Education, Training, & Certifications
- Assistant Professor - Research, Department Of Radiation Oncology, University of Colorado School of Medicine 2009 - 2011
- Research Instructor, Department Of Radiation Oncology, University of Colorado School of Medicine 2006 - 2009
- Research Associate, Department Of Radiation Oncology, Duke University 2003 - 2006
- Postdoctoral Fellow, Department Of Molecular Sciences, University of Tennessee, Memphis 2001 - 2003
- Research Scientist / Vice Director, Guangzhou Institute Of Trauma, Guangzhou Medical College (China) 1996 - 2001
- Ph.D., Sun Yat Sen University (China) 2001
- Research Associate, Guangzhoured Cross Hospital, Guangzhou Medical College (China) 1987 - 1996
- B.S., Sichuan University 1987
Research
Selected Grants
- Pro-oncogenic roles of apoptotic caspases awarded by National Institutes of Health 2014 - 2029
- Targeting apoptotic caspases to enhance cancer radiotherapy awarded by National Institutes of Health 2017 - 2022
- Necroptotic genes in cancer cellular response to radiation awarded by National Institutes of Health 2017 - 2022
- Molecular Mechanisms of Tumor Response to Cytotoxic Chemotherapy awarded by National Institutes of Health 2011 - 2016
- HIF Genes in Head and Neck Cancer Radiotherapy awarded by National Institutes of Health 2012 - 2015
- A mechanistic investigation of space radiation-induced carcinogensis awarded by National Aeronautics and Space Administration 2012 - 2013
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Zhao, R, Kaakati, R, Lee, AK, Liu, X, Li, F, and Li, C-Y. "Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond." Cancer Metastasis Reviews 37, no. 2-3 (September 2018): 227-236. Full Text
  - Zhou, M, Liu, X, Li, Z, Huang, Q, Li, F, and Li, C-Y. "Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells." International Journal of Cancer 143, no. 4 (August 2018): 921-930. Full Text
  - Cartwright, IM, Liu, X, Zhou, M, Li, F, and Li, C-Y. "Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis." Elife 6 (July 10, 2017). Full Text
  - Liu, X, Li, F, Huang, Q, Zhang, Z, Zhou, L, Deng, Y, Zhou, M, Fleenor, DE, Wang, H, Kastan, MB, and Li, C-Y. "Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells." Cell research 27, no. 6 (June 2017): 764-783. Full Text
  - Li, F, Liu, X, Sampson, JH, Bigner, DD, and Li, C-Y. "Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors." Cancer Research 76, no. 17 (September 2016): 5143-5150. Full Text
  - Liu, X, He, Y, Li, F, Huang, Q, Kato, TA, Hall, RP, and Li, C-Y. "Redefining the roles of apoptotic factors in carcinogenesis." Molecular & Cellular Oncology 3, no. 3 (May 2016): e1054550-null. Full Text
  - Liu, X, Zhou, M, Mei, L, Ruan, J, Hu, Q, Peng, J, Su, H, Liao, H, Liu, S, Liu, W, Wang, H, Huang, Q, Li, F, and Li, C-Y. "Key roles of necroptotic factors in promoting tumor growth." Oncotarget 7, no. 16 (April 2016): 22219-22233. Full Text
  - Liu, X, He, Y, Li, F, Huang, Q, Kato, TA, Hall, RP, and Li, C-Y. "Caspase-3 promotes genetic instability and carcinogenesis." Molecular Cell 58, no. 2 (April 9, 2015): 284-296. Full Text
  - Liu, X, He, Y, Li, F, Huang, Q, Kato, TA, Hall, RP, and Li, CY. "Caspase-3 Promotes Genetic Instability and Carcinogenesis." Molecular Cell 58, no. 2 (January 1, 2015): 284-296. Full Text
  - Liu, X, Huang, Q, Li, F, and Li, C-Y. "Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression." Science China. Life Sciences 57, no. 9 (September 2014): 867-875. Full Text
  - Donato, AL, Huang, Q, Liu, X, Li, F, Zimmerman, MA, and Li, C-Y. "Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy." The Journal of Investigative Dermatology 134, no. 6 (June 2014): 1686-1692. Full Text
  - Donato, AL, Huang, Q, Liu, X, Li, F, Zimmerman, MA, and Li, C-Y. "Caspase 3 Promotes Surviving Melanoma Tumor Cell Growth after Cytotoxic Therapy." Journal of Investigative Dermatology 134, no. 6 (June 2014): 1686-1692. Full Text
  - Ng, W-L, Huang, Q, Liu, X, Zimmerman, M, Li, F, and Li, C-Y. "Molecular mechanisms involved in tumor repopulation after radiotherapy." Translational Cancer Research 2, no. 5 (October 2013): 442-448. Full Text
  - Zimmerman, MA, Huang, Q, Li, F, Liu, X, and Li, C-Y. "Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy." Seminars in Radiation Oncology 23, no. 4 (October 2013): 288-295. (Review) Full Text
  - Wang, S, Huang, J, Lyu, H, Cai, B, Yang, X, Li, F, Tan, J, Edgerton, SM, Thor, AD, Lee, C-K, and Liu, B. "Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer." Breast Cancer Research : Bcr 15, no. 5 (January 2013): R101-null. Full Text
  - Kon, T, Zhang, X, Huang, Q, Yang, Z, Liu, S, Yan, B, Li, F, Wang, H, and Li, C-Y. "Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA." Translational Cancer Research 1, no. 2 (June 2012): 4-14. Full Text
  - Brogan, J, Li, F, Li, W, He, Z, Huang, Q, and Li, C-Y. "Imaging molecular pathways: reporter genes." Radiation Research 177, no. 4 (April 2012): 508-513. (Review) Full Text
  - Liu, X, Li, F, Stubblefield, EA, Blanchard, B, Richards, TL, Larson, GA, He, Y, Huang, Q, Tan, A-C, Zhang, D, Benke, TA, Sladek, JR, Zahniser, NR, and Li, C-Y. "Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells." Cell Research 22, no. 2 (February 2012): 321-332. Full Text
  - Li, F, Ryu, BY, Krueger, RL, Heldt, SA, and Albritton, LM. "Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins." Journal of Virology 86, no. 1 (January 2012): 373-381. Full Text
  - Huang, Q, Li, F, Liu, X, Li, W, Shi, W, Liu, F-F, O'Sullivan, B, He, Z, Peng, Y, Tan, A-C, Zhou, L, Shen, J, Han, G, Wang, X-J, Thorburn, J, Thorburn, A, Jimeno, A, Raben, D, Bedford, JS, and Li, C-Y. "Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy." Nature Medicine 17, no. 7 (July 3, 2011): 860-866. Full Text
  - Li, W, Li, F, Huang, Q, Shen, J, Wolf, F, He, Y, Liu, X, Hu, YA, Bedford, JS, and Li, C-Y. "Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo." Cancer Research 71, no. 12 (June 2011): 4130-4137. Full Text
  - Wolf, F, Li, W, Li, F, and Li, C-Y. "Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours." International Journal of Hyperthermia 27, no. 5 (2011): 427-434. Full Text
  - Wolf, F, Li, W, Li, F, and Li, C-Y. "Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy." International Journal of Radiation Oncology Biology Physics 79, no. 1 (2011): 233-238. Full Text
  - Li, F, Huang, Q, Chen, J, Peng, Y, Roop, DR, Bedford, JS, and Li, C-Y. "Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration." Science Signaling 3, no. 110 (February 23, 2010): ra13-null. Full Text
  - Li, F, He, Z, Shen, J, Huang, Q, Li, W, Liu, X, He, Y, Wolf, F, and Li, C-Y. "Apoptotic caspases regulate induction of iPSCs from human fibroblasts." Cell Stem Cell 7, no. 4 (2010): 508-520. Full Text
  - Viola, RJ, Provenzale, JM, Li, F, Li, C-Y, Yuan, H, Tashjian, J, and Dewhirst, MW. "In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy." AJR Am J Roentgenol 191, no. 6 (December 2008): 1779-1784. Full Text Link to Item
  - Li, W, Li, F, Huang, Q, Frederick, B, Bao, S, and Li, C-Y. "Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo." Cancer Research 68, no. 13 (July 2008): 4990-4997. Full Text
  - Li, F, Sonveaux, P, Rabbani, ZN, Liu, S, Yan, B, Huang, Q, Vujaskovic, Z, Dewhirst, MW, and Li, C-Y. "Regulation of HIF-1alpha stability through S-nitrosylation." Molecular Cell 26, no. 1 (April 2007): 63-74. Full Text
  - Yan, B, Wang, H, Li, F, and Li, C-Y. "Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation." Br J Cancer 95, no. 12 (December 18, 2006): 1696-1700. Full Text Link to Item
  - Yan, B, Wang, H, Rabbani, ZN, Zhao, Y, Li, W, Yuan, Y, Li, F, Dewhirst, MW, and Li, C-Y. "Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation." Cancer Research 66, no. 24 (December 2006): 11565-11570. Full Text
  - Yan, B, Wang, H, Wang, H, Zhuo, D, Li, F, Kon, T, Dewhirst, M, and Li, C-Y. "Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner." Oncogene 25, no. 39 (August 31, 2006): 5370-5376. Full Text Link to Item
  - Liu, S, Wang, H, Yang, Z, Kon, T, Zhu, J, Cao, Y, Li, F, Kirkpatrick, J, Nicchitta, CV, and Li, C-Y. "Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression." Cancer Res 65, no. 20 (October 15, 2005): 9126-9131. Full Text Link to Item
  - Zhang, X, Kon, T, Wang, H, Li, F, Huang, Q, Rabbani, ZN, Kirkpatrick, JP, Vujaskovic, Z, Dewhirst, MW, and Li, C-Y. "Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha." Cancer Res 64, no. 22 (November 15, 2004): 8139-8142. Full Text Link to Item

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Education, Training, & Certifications

Selected Grants

Selected Publications

Journal Articles