Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Assistant Professor - Research, Department Of Radiation Oncology, University of Colorado School of Medicine 2009 - 2011
  • Research Instructor, Department Of Radiation Oncology, University of Colorado School of Medicine 2006 - 2009
  • Research Associate, Department Of Radiation Oncology, Duke University 2003 - 2006
  • Postdoctoral Fellow, Department Of Molecular Sciences, University of Tennessee Health Science Center 2001 - 2003
  • Research Scientist / Vice Director, Guangzhou Institute Of Trauma, Guangzhou Medical College (China) 1996 - 2001
  • Ph.D., Sun Yat Sen University (China) 2001
  • Research Associate, Guangzhoured Cross Hospital, Guangzhou Medical College (China) 1987 - 1996
  • B.S., Sichuan University (China) 1987
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Dermatology, Dermatology, Clinical Science Departments 2011 - 2020
• Research
• 

  Selected Grants

  • Targeting ATM to boost systemic effects of radiotherapy and immunotherapy awarded by National Institutes of Health 2021 - 2026
  • Necroptotic genes in cancer cellular response to radiation awarded by National Institutes of Health 2017 - 2023
  • Targeting apoptotic caspases to enhance cancer radiotherapy awarded by National Institutes of Health 2017 - 2022
  • Pro-oncogenic roles of apoptotic caspases awarded by National Institutes of Health 2014 - 2020
  • Molecular Mechanisms of Tumor Response to Cytotoxic Chemotherapy awarded by National Institutes of Health 2011 - 2016
  • HIF Genes in Head and Neck Cancer Radiotherapy awarded by National Institutes of Health 2012 - 2015
  • A mechanistic investigation of space radiation-induced carcinogensis awarded by National Aeronautics and Space Administration 2012 - 2013
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hu, Mengjie, Min Zhou, Xuhui Bao, Dong Pan, Meng Jiao, Xinjian Liu, Fang Li, and Chuan-Yuan Li. “ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation.” J Clin Invest 131, no. 3 (February 1, 2021). https://doi.org/10.1172/JCI139333.
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    • Liu, Xinjian, Xuhui Bao, Mengjie Hu, Hanman Chang, Meng Jiao, Jin Cheng, Liyi Xie, Qian Huang, Fang Li, and Chuan-Yuan Li. “Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.” Nature 588, no. 7839 (December 2020): 693–98. https://doi.org/10.1038/s41586-020-2911-7.
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    • Liu, Xinjian, Mengjie Hu, Pei Liu, Meng Jiao, Min Zhou, Andrew K. Lee, Fang Li, and Chuan-Yuan Li. “ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.” Cancer Res 80, no. 8 (April 15, 2020): 1669–80. https://doi.org/10.1158/0008-5472.CAN-19-2255.
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    • Lee, Andrew K., Dong Pan, Xuhui Bao, Mengjie Hu, Fang Li, and Chuan-Yuan Li. “Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy.” Radiat Res 193, no. 4 (April 2020): 305–17. https://doi.org/10.1667/RADE-20-00013.
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    • Bao, Xuhui, Xinjian Liu, Fang Li, and Chuan-Yuan Li. “Limited MOMP, ATM, and their roles in carcinogenesis and cancer treatment.” Cell Biosci 10 (2020): 81. https://doi.org/10.1186/s13578-020-00442-y.
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    • Zhao, Ruya, Rayan Kaakati, Andrew K. Lee, Xinjian Liu, Fang Li, and Chuan-Yuan Li. “Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond.” Cancer Metastasis Rev 37, no. 2–3 (September 2018): 227–36. https://doi.org/10.1007/s10555-018-9736-y.
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    • Zhou, Min, Xinjian Liu, Zonghai Li, Qian Huang, Fang Li, and Chuan-Yuan Li. “Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells.” Int J Cancer 143, no. 4 (August 15, 2018): 921–30. https://doi.org/10.1002/ijc.31374.
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    • Cartwright, Ian M., Xinjian Liu, Min Zhou, Fang Li, and Chuan-Yuan Li. “Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis.” Elife 6 (July 10, 2017). https://doi.org/10.7554/eLife.26371.
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    • Liu, Xinjian, Fang Li, Qian Huang, Zhengxiang Zhang, Ling Zhou, Yu Deng, Min Zhou, et al. “Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells.” Cell Res 27, no. 6 (June 2017): 764–83. https://doi.org/10.1038/cr.2017.41.
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    • Li, Fang, Xinjian Liu, John H. Sampson, Darell D. Bigner, and Chuan-Yuan Li. “Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors.” Cancer Res 76, no. 17 (September 1, 2016): 5143–50. https://doi.org/10.1158/0008-5472.CAN-16-0171.
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    • Liu, Xinjian, Yujun He, Fang Li, Qian Huang, Takamitsu A. Kato, Russell P. Hall, and Chuan-Yuan Li. “Redefining the roles of apoptotic factors in carcinogenesis.” Mol Cell Oncol 3, no. 3 (May 2016): e1054550. https://doi.org/10.1080/23723556.2015.1054550.
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    • Liu, Xinjian, Min Zhou, Ling Mei, Jiaying Ruan, Qian Hu, Jing Peng, Hang Su, et al. “Key roles of necroptotic factors in promoting tumor growth.” Oncotarget 7, no. 16 (April 19, 2016): 22219–33. https://doi.org/10.18632/oncotarget.7924.
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    • Liu, Xinjian, Yujun He, Fang Li, Qian Huang, Takamitsu A. Kato, Russell P. Hall, and Chuan-Yuan Li. “Caspase-3 promotes genetic instability and carcinogenesis.” Mol Cell 58, no. 2 (April 16, 2015): 284–96. https://doi.org/10.1016/j.molcel.2015.03.003.
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    • Liu, XinJian, Qian Huang, Fang Li, and Chuan-Yuan Li. “Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression.” Sci China Life Sci 57, no. 9 (September 2014): 867–75. https://doi.org/10.1007/s11427-014-4730-2.
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    • Donato, Anne L., Qian Huang, Xinjian Liu, Fang Li, Mary A. Zimmerman, and Chuan-Yuan Li. “Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy.” J Invest Dermatol 134, no. 6 (June 2014): 1686–92. https://doi.org/10.1038/jid.2014.18.
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    • Donato, A. L., Q. Huang, X. Liu, F. Li, M. A. Zimmerman, and C. Y. Li. “Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy.” Journal of Investigative Dermatology 134, no. 6 (January 1, 2014): 1686–92. https://doi.org/10.1038/jid.2014.18.
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    • Ng, Wooi-Loon, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, and Chuan-Yuan Li. “Molecular mechanisms involved in tumor repopulation after radiotherapy.” Transl Cancer Res 2, no. 5 (October 1, 2013): 442–48. https://doi.org/10.3978/j.issn.2218-676X.2013.10.03.
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    • Zimmerman, Mary A., Qian Huang, Fang Li, Xinjiang Liu, and Chuan-Yuan Li. “Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy.” Semin Radiat Oncol 23, no. 4 (October 2013): 288–95. https://doi.org/10.1016/j.semradonc.2013.05.003.
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    • Wang, Shuiliang, Jingcao Huang, Hui Lyu, Bo Cai, Xiaoping Yang, Fang Li, Jianming Tan, et al. “Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer.” Breast Cancer Res 15, no. 5 (2013): R101. https://doi.org/10.1186/bcr3563.
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    • Kon, Takashi, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, and Chuan-Yuan Li. “Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA.” Transl Cancer Res 1, no. 2 (June 2012): 4–14. https://doi.org/10.3978/j.issn.2218-676X.2012.05.02.
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    • Brogan, John, Fang Li, Wenrong Li, Zhimin He, Qian Huang, and Chuan-Yuan Li. “Imaging molecular pathways: reporter genes.” Radiat Res 177, no. 4 (April 2012): 508–13. https://doi.org/10.1667/rr2918.1.
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    • Liu, Xinjian, Fang Li, Elizabeth A. Stubblefield, Barbara Blanchard, Toni L. Richards, Gaynor A. Larson, Yujun He, et al. “Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.” Cell Res 22, no. 2 (February 2012): 321–32. https://doi.org/10.1038/cr.2011.181.
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    • Li, Fang, Byoung Y. Ryu, Robin L. Krueger, Scott A. Heldt, and Lorraine M. Albritton. “Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins.” J Virol 86, no. 1 (January 2012): 373–81. https://doi.org/10.1128/JVI.05411-11.
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    • Huang, Qian, Fang Li, Xinjian Liu, Wenrong Li, Wei Shi, Fei-Fei Liu, Brian O’Sullivan, et al. “Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.” Nat Med 17, no. 7 (July 3, 2011): 860–66. https://doi.org/10.1038/nm.2385.
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    • Li, Wenrong, Fang Li, Qian Huang, Jingping Shen, Frank Wolf, Yujun He, Xinjian Liu, Y Angela Hu, Joel S. Bedford, and Chuan-Yuan Li. “Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo.” Cancer Res 71, no. 12 (June 15, 2011): 4130–37. https://doi.org/10.1158/0008-5472.CAN-10-2540.
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    • Wolf, Frank, Wenrong Li, Fang Li, and Chuan-Yuan Li. “Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours.” Int J Hyperthermia 27, no. 5 (2011): 427–34. https://doi.org/10.3109/02656736.2011.566593.
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    • Wolf, Frank, Wenrong Li, Fang Li, and Chuan-Yuan Li. “Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy.” Int J Radiat Oncol Biol Phys 79, no. 1 (January 1, 2011): 233–38. https://doi.org/10.1016/j.ijrobp.2010.08.001.
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    • Li, Fang, Zhimin He, Jingping Shen, Qian Huang, Wenrong Li, Xinjian Liu, Yujun He, Frank Wolf, and Chuan-Yuan Li. “Apoptotic caspases regulate induction of iPSCs from human fibroblasts.” Cell Stem Cell 7, no. 4 (October 8, 2010): 508–20. https://doi.org/10.1016/j.stem.2010.09.003.
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    • Li, Fang, Qian Huang, Jiang Chen, Yuanlin Peng, Dennis R. Roop, Joel S. Bedford, and Chuan-Yuan Li. “Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.” Sci Signal 3, no. 110 (February 23, 2010): ra13. https://doi.org/10.1126/scisignal.2000634.
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    • Viola, Ronald J., James M. Provenzale, Fang Li, Chuan-Yuan Li, Hong Yuan, Jessica Tashjian, and Mark W. Dewhirst. “In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.” Ajr Am J Roentgenol 191, no. 6 (December 2008): 1779–84. https://doi.org/10.2214/AJR.07.4060.
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    • Li, Wenrong, Fang Li, Qian Huang, Barbara Frederick, Shideng Bao, and Chuan-Yuan Li. “Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.” Cancer Res 68, no. 13 (July 1, 2008): 4990–97. https://doi.org/10.1158/0008-5472.CAN-07-5984.
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    • Li, Fang, Pierre Sonveaux, Zahid N. Rabbani, Shanling Liu, Bin Yan, Qian Huang, Zeljko Vujaskovic, Mark W. Dewhirst, and Chuan-Yuan Li. “Regulation of HIF-1alpha stability through S-nitrosylation.” Mol Cell 26, no. 1 (April 13, 2007): 63–74. https://doi.org/10.1016/j.molcel.2007.02.024.
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    • Yan, B., H. Wang, F. Li, and C. -. Y. Li. “Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.” Br J Cancer 95, no. 12 (December 18, 2006): 1696–1700. https://doi.org/10.1038/sj.bjc.6603484.
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    • Yan, Bin, Huili Wang, Zahid N. Rabbani, Yulin Zhao, Wenrong Li, Yuqing Yuan, Fang Li, Mark W. Dewhirst, and Chuan-Yuan Li. “Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation.” Cancer Res 66, no. 24 (December 15, 2006): 11565–70. https://doi.org/10.1158/0008-5472.CAN-06-2540.
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    • Yan, B., H. Wang, D. Zhuo, F. Li, T. Kon, M. Dewhirst, and C. -. Y. Li. “Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.” Oncogene 25, no. 39 (August 31, 2006): 5370–76. https://doi.org/10.1038/sj.onc.1209535.
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    • Liu, Shanling, He Wang, Zhonghui Yang, Takashi Kon, Jiangao Zhu, Yiting Cao, Fang Li, John Kirkpatrick, Christopher V. Nicchitta, and Chuan-Yuan Li. “Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.” Cancer Res 65, no. 20 (October 15, 2005): 9126–31. https://doi.org/10.1158/0008-5472.CAN-05-0945.
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    • Zhang, Xiuwu, Takashi Kon, He Wang, Fang Li, Qian Huang, Zahid N. Rabbani, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst, and Chuan-Yuan Li. “Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha.” Cancer Res 64, no. 22 (November 15, 2004): 8139–42. https://doi.org/10.1158/0008-5472.CAN-03-2301.
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