Skip to main content

Fay-Wei Li

Associate Professor of Biology
Biology
137 Biosci Box 90338, Durham, NC 27708
124 Science Drive FFSC 3332, Durham, NC 27708

Overview


We seek to explore the fascinating but obscure biology of seed-free plants (i.e., ferns, lycophytes, and bryophytes). Our scope is broad, ranging from biodiversity research, plant-microbe interaction, comparative genomics, molecular genetics, to protein biochemistry. The current thrust of our research activities centers on cyanobacteria symbiosis, CO2-concentrating mechanism, and sex chromosomes in hornworts, and the evolution of giant genomes in ferns and lycophytes. 

Current Duke Appointments & Affiliations


Associate Professor of Biology · 2026 - Present Biology, Trinity College of Arts & Sciences

Recent Scholarly Works


Hornwort pyrenoids: a terrestrial exception with engineering lessons.

Journal article Plant physiology · April 2026 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) underpins nearly all primary production yet remains a slow, error-prone enzyme because it catalyzes both carboxylation and oxygenation, the latter initiating photorespiration and reducing net carbon ... Full text Cite

An unconventional Rubisco small subunit underpins the CO<sub>2</sub>-concentrating organelle in land plants.

Journal article Science (New York, N.Y.) · March 2026 In many algae, photosynthesis is boosted by biophysical CO2-concentrating mechanisms, which pack the CO2-fixing enzyme Rubisco into liquid-like organelles called pyrenoids. Engineering C3 crops with algal pyrenoids could in ... Full text Cite

Nitroxysomes as a Potential Solution for Engineering Biological Nitrogen Fixation.

Journal article ACS synthetic biology · February 2026 Nitrogenase catalyzes the reduction of atmospheric nitrogen gas to ammonia, forming the foundation of biological nitrogen fixation in diazotrophic microbes. While functional nitrogenase can be assembled in non-native hosts, its activity is severely limited ... Full text Cite
View All Scholarly Works

Education


Duke University · 2015 Ph.D.