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Felicia Ruffin

Research Program Leader, Tier 1
Medicine, Infectious Diseases
Box 102359 DUMC, Durham, NC 27710
0207 F Hosp South, Durham, NC 27710

Current Appointments & Affiliations


Research Program Leader, Tier 1 Medicine, Infectious Diseases, Medicine

Recent Publications


Reproducible Identification of Staphylococcus aureus Bacteremia Clinical Subphenotypes.

Journal Article Clin Infect Dis · April 30, 2026 BACKGROUND: Clinical heterogeneity in Staphylococcus aureus bacteremia (SAB) complicates clinical management and research. We have previously identified 5 clinically distinct subphenotypes of SAB associated with differences in outcomes and response to adju ... Full text Link to item Cite

Virulence Phenotypes Differentiate Persistent vs. Resolving Isolates of Human Staphylococcus aureus Bacteremia.

Journal Article Antibiotics (Basel) · March 25, 2026 BACKGROUND: Staphylococcus aureus bacteremia (SAB) is a common and life-threatening bloodstream infection often caused by methicillin-resistant SA (MRSA) isolates. Up to 35% of SAB patients fail to clear infection with gold-standard anti-MRSA antibiotics, ... Full text Link to item Cite

Genetics and environment distinctively shape the human immune cell epigenome.

Journal Article Nat Genet · February 2026 The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for transposase-acce ... Full text Link to item Cite
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Recent Grants


Genomic determinants of antibiotic treatment failure in S. aureus bacteremia

ResearchResearch Program Leader · Awarded by National Institutes of Health · 2024 - 2029

Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality

ResearchResearch Program Leader · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

HLA Fine Mapping to Elucidate S. aureus Susceptibility - R01 RPPR

ResearchClinical Research Nurse · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026

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