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Felicia Ruffin

Research Program Leader, Tier 1
Medicine, Infectious Diseases
Box 102359 DUMC, Durham, NC 27710
0207 F Hosp South, Durham, NC 27710

Current Appointments & Affiliations


Research Program Leader, Tier 1 Medicine, Infectious Diseases, Medicine

Recent Publications


Reproducible identification of Staphylococcus aureus bacteremia clinical subphenotypes.

Journal Article Clin Infect Dis · November 27, 2025 BACKGROUND: Clinical heterogeneity in Staphylococcus aureus bacteremia (SAB) complicates clinical management and research. We have previously identified five clinically distinct subphenotypes of SAB associated with differences in outcomes and response to a ... Full text Link to item Cite

Escherichia coli Type III Secretion System 2 Is Associated With Patient Mortality in Bloodstream Infections.

Journal Article J Infect Dis · November 14, 2025 BACKGROUND: Escherichia coli has an extensive accessory genome, though its role in affecting patient mortality is unknown. METHODS: We performed whole genome sequencing with E. coli bacteremia isolates. Pan-genome analysis was used to identify flexible gen ... Full text Link to item Cite

Female Sex and Mortality in Patients With Gram-Negative Bacteremia: A Systematic Review and Meta-Analysis.

Journal Article JAMA Netw Open · November 3, 2025 IMPORTANCE: Female sex has been identified as a risk factor for mortality in Staphylococcus aureus bloodstream infection (SA-BSI). It is unknown whether this association extends to bloodstream infections with other bacterial species. OBJECTIVE: To investig ... Full text Link to item Cite
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Recent Grants


Genomic determinants of antibiotic treatment failure in S. aureus bacteremia

ResearchResearch Program Leader · Awarded by National Institutes of Health · 2024 - 2029

Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality

ResearchResearch Program Leader · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

HLA Fine Mapping to Elucidate S. aureus Susceptibility - R01 RPPR

ResearchClinical Research Nurse · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026

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