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Felicia Ruffin

Research Program Leader, Tier 1
Medicine, Infectious Diseases
Box 102359 DUMC, Durham, NC 27710
0207 F Hosp South, Durham, NC 27710

Current Appointments & Affiliations


Research Program Leader, Tier 1 Medicine, Infectious Diseases, Medicine

Recent Publications


Early cytokine signatures and clinical phenotypes discriminate persistent from resolving MRSA bacteremia.

Journal Article BMC Infect Dis · February 18, 2025 BACKGROUND: Staphylococcus aureus bacteremia (SAB) is a prevalent life-threatening infection often caused by methicillin-resistant S. aureus (MRSA). Up to 30% of SAB patients fail to clear infection even with gold-standard anti-MRSA antibiotics. This pheno ... Full text Link to item Cite

Combination Therapy Is Not Associated with Decreased Mortality in Infectious Endocarditis: A Systematic Review and Meta-Analysis.

Journal Article Microorganisms · November 2, 2024 Untreated infective endocarditis (IE) is uniformly fatal. The practice of combination antibiotic therapy for IE is recommended by treatment guidelines but largely unsupported by high-quality evidence. This study aimed to assess the efficacy of combination ... Full text Link to item Cite

A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease.

Journal Article J Antimicrob Chemother · September 3, 2024 OBJECTIVES: Escherichia coli can cause infections in the urinary tract and in normally sterile body sites leading to invasive E. coli disease (IED), including bacteraemia and sepsis, with older populations at increased risk. We aimed to estimate the theore ... Full text Link to item Cite
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Recent Grants


Genomic determinants of antibiotic treatment failure in S. aureus bacteremia

ResearchClinical Research Coordinator · Awarded by National Institutes of Health · 2024 - 2029

Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality

ResearchResearch Program Leader · Awarded by National Institutes of Health · 2022 - 2027

HLA Fine Mapping to Elucidate S. aureus Susceptibility - R01 RPPR

ResearchClinical Research Nurse · Awarded by National Institutes of Health · 2021 - 2026

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