Scholars@Duke
Fengming Chen

Fengming Chen

Assistant Professor of Pathology
Pathology
fengming.chen@duke.edu
Room 302M, Davison Building, Duke South Green Zone, Durham, NC 27710
Room 302M, Davison Building, Duke South Green Zone, Durham, NC 27710

Selected Publications

The utility of the mHAI scoring system in pediatric autoimmune hepatitis diagnosis and its association with treatment response.

Journal Article Ann Diagn Pathol · December 2024 Autoimmune hepatitis (AIH) is a chronic inflammatory autoimmune disease with either acute or chronic presentation. Previous scoring systems have primarily focused on chronic hepatitis, but none have been validated in an acute setting of pediatric patients. ... Full text Link to item Cite

Optimizing DCD Liver Grafts With Prolonged Warm Ischemic Time Using Stabilized Plasmin in a Static Cold Storage Orthotopic Rat Liver Transplant Model.

Journal Article Transplant Direct · August 2024 BACKGROUND: The clinical success of liver transplantation has led to increased demand, requiring further expansion of the donor pool. Therapeutic interventions to optimize organs from donation after circulatory death (DCD) have significant potential to mit ... Full text Link to item Cite

Extra-appendiceal mucinous neoplasms: A tumour with clinicopathologic similarities to low- and high-grade appendiceal counterpart.

Journal Article Hum Pathol · June 2024 AIMS: Appendiceal mucinous neoplasms feature neoplastic mucinous epithelium with pushing borders and densely fibrotic walls. We have identified five examples of analogous colorectal tumours. METHODS AND RESULTS: Slides, pathology reports, and clinical data ... Full text Link to item Cite

Idiopathic Megaduodenum in a Teenager: A Case Report.

Journal Article Cureus · January 2024 Megaduodenum is a rare clinical syndrome characterized by significant duodenal dilation, elongation, and hypertrophy. Given its rarity and nonspecific clinical manifestations, megaduodenum may be misdiagnosed, leading to delays in surgical care and increas ... Full text Open Access Link to item Cite

Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs.

Journal Article Mod Pathol · April 2022 Risk stratification of gastrointestinal stromal tumors (GISTs) is based on experience with tumors of the stomach, small bowel, and rectum, which are far more common than GISTs of other sites. In this study from 47 institutions, we analyzed GISTs of the eso ... Full text Link to item Cite

A Contemporary Clinicopathologic Analysis of Primary Urothelial Carcinoma of the Urethra Without Concurrent Renal Pelvic, Ureteral, or Bladder Carcinoma.

Journal Article Int J Surg Pathol · February 2022 Primary urothelial carcinoma (UCa) of the urethra is relatively uncommon, and the underlying pathogenesis has not been well characterized, especially in the absence of concurrent UCa at other sites. A search for cases of primary UCa of the urethra was cond ... Full text Link to item Cite

Diagnostic challenges of intra-operative frozen consultation for gastrointestinal signet ring cell carcinoma†.

Journal Article Histopathology · January 2021 AIMS: Signet ring cell carcinoma (SRCC) is challenging to recognise on intra-operative frozen sections, with known high false-negative rates. The objective of this study was to investigate common factors contributing to discrepancies between intra-operativ ... Full text Link to item Cite

Giant Primary Retroperitoneal Serous Cystadenoma: A Rare Entity Mimicking Multiple Neoplastic and Nonneoplastic Processes.

Journal Article Arch Pathol Lab Med · April 2020 Serous cystadenoma, often known as ovarian serous cystadenoma, is one of the common benign ovarian neoplasms. On the other hand, primary retroperitoneal serous cystadenoma is an extremely rare benign entity whose pathogenesis has not been well understood. ... Full text Link to item Cite

Hit or a miss: Concordance between histopathologic-endoscopic findings in gastric mucosal biopsies.

Journal Article Ann Diagn Pathol · February 2019 BACKGROUND: Current literature shows a variable degree of concordance between endoscopic and histopathologic findings in gastric mucosal biopsies. Most prior studies have focused on specific gastric entities such as gastritis in patients with high prevalen ... Full text Link to item Cite

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism.

Journal Article J Proteome Res · January 4, 2019 The constitutive androstane receptor (CAR; NR1I3) contributes important regulatory roles in biotransformation, xenobiotic transport function, energy metabolism and lipid homeostasis. In this investigation, global serum and liver tissue metabolomes were ass ... Full text Link to item Cite

Pseudohyperphosphatemia in a patient with incidentally identified progression of smoldering myeloma.

Journal Article Clin Chim Acta · December 2018 BACKGROUND: Pseudohyperphosphatemia is a rare laboratory finding in MM, especially in patients with smoldering myeloma (SMM) progressing to symptomatic multiple myeloma (MM). Laboratorians and clinicians should be aware of this phenomenon and take necessar ... Full text Link to item Cite

Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.

Journal Article Biochem J · February 15, 2014 The CAR (constitutive androstane receptor; NR1I3) is a critical xenobiotic sensor that regulates xenobiotic metabolism, drug clearance, energy and lipid homoeostasis, cell proliferation and development. Although constitutively active, in hepatocytes CAR is ... Full text Link to item Cite

The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells.

Journal Article Dev Biol · December 15, 2013 Expression of the constitutive androstane receptor (CAR, NR1I3) is enriched in the mature mammalian liver and increasingly recognized for its prominent role in regulating a myriad of processes including biotransformation, chemical transport, energy metabol ... Full text Link to item Cite

Differentiation of human embryonic stem cells along a hepatic lineage.

Journal Article Chem Biol Interact · March 15, 2011 The limited availability of hepatic tissue suitable for the treatment of liver disease and drug discovery research advances the generation of hepatic-like cells from alternative sources as a valuable approach. In this investigation we exploited a unique he ... Full text Link to item Cite

Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity.

Journal Article J Biol Chem · January 28, 2011 Extracellular signal-regulated kinase-1 and -2 (ERK1/2) proteins regulate a variety of cellular functions, including cell proliferation and differentiation, by interacting with and phosphorylating substrate proteins. Two docking sites, common docking (CD/E ... Full text Link to item Cite

NO inhibits hyperoxia-induced NF-κB activation in neonatal pulmonary microvascular endothelial cells.

Journal Article Pediatr Res · December 2010 Inhaled NO (iNO) may be protective against hyperoxic injury in the premature lung, but the mechanism is unknown. We hypothesized that NO would prevent hyperoxia-induced nuclear factor kappa B (NF-κB) activation in neonatal pulmonary microvascular endotheli ... Full text Link to item Cite

Using Caenorhabditis elegans as a model organism for evaluating extracellular signal-regulated kinase docking domain inhibitors.

Journal Article J Cell Commun Signal · December 2008 We have recently identified several novel ATP-independent inhibitors that target the extracellular signal-regulated kinase-2 (ERK2) protein and inhibit substrate phosphorylation. To further characterize these compounds, we describe the use of C. elegans as ... Full text Link to item Cite

Valepotriate-induced apoptosis of gastric cancer cell line MKN-45

Journal Article World Chinese Journal of Digestology · January 1, 2007 AIM: To study the apoptosis of gastric cancer cell line MKN-45 induced by valepotriate and its relationship with the expression of Caspase, P53, and Survivin. METHODS: Gastric cancer cell line MKN-45 was divided into 4 groups, named group A (control), B (t ... Full text Cite

Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure.

Journal Article Bioorg Med Chem Lett · December 15, 2006 The extracellular signal-regulated kinases (ERK1 and ERK2) are important mediators of cell proliferation. Constitutive activation of the ERK proteins plays a critical role in the proliferation of many human cancers. Taking advantage of recently identified ... Full text Link to item Cite

Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.

Journal Article Cell Prolif · August 2006 Extracellular signal-regulated kinase activity is essential for mediating cell cycle progression from G(1) phase to S phase (DNA synthesis). In contrast, the role of extracellular signal-regulated kinase during G(2) phase and mitosis (M phase) is largely u ... Full text Link to item Cite

Variations of very low-density lipoprotein receptor subtype expression in gastrointestinal adenocarcinoma cells with various differentiations.

Journal Article World J Gastroenterol · May 14, 2005 AIM: This study is aimed at investigating the expression and possible significances of very low-density lipoprotein receptor (VLDLR) subtypes in gastroenteric adenocarcinoma tissues and cells with various differentiations. METHODS: Thirty-one cases of gast ... Full text Link to item Cite

Effect of fatty acid synthase inhibitor on growth and apoptosis of human gastric cancer cells

Journal Article World Chinese Journal of Digestology · January 1, 2004 AIM: To investigate the effect of fatty acid synthase inhibitor-cerulenin on the growth and apoptosis of human gastric cancer cells. METHODS: The inhibitory effect of cerulenin was observed at 2.5, 5, 10, 20 and 40 mg/L on the growth of MKN28, SGC7901 and ... Full text Cite