Greg D. Field
Assistant Professor of Neurobiology
My laboratory studies how the retina processes visual scenes and transmits this information to the brain. We use multi-electrode arrays to record the activity of hundreds of retina neurons simultaneously in conjunction with transgenic mouse lines and chemogenetics to manipulate neural circuit function. We are interested in three major areas. First, we work to understand how neurons in the retina are functionally connected. Second we are studying how light-adaptation and circadian rhythms alter visual processing in the retina. Finally, we are working to understand the mechanisms of retinal degenerative conditions and we are investigating potential treatments in animal models.
Current Appointments & Affiliations
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2015
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2015
Contact Information
- Box 3209, Durham, NC 27710
- Bryan Research Building, 311 Research Drive Room 427D, Durham, NC 27710
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field@neuro.duke.edu
(919) 681-7503
- Background
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Education, Training, & Certifications
- Ph.D., University of Washington 2004
- Recognition
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In the News
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SEP 13, 2018
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- Expertise
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Subject Headings
- Action Potentials
- Adaptation, Physiological
- Algorithms
- Aminobutyrates
- Animals
- Artifacts
- Axons
- Bayesian Statistical Decision Theory
- Behavior, Animal
- Calcium
- Calibration
- Cells, Cultured
- Chelating Agents
- Color Vision
- Computer Simulation
- Contrast Sensitivity
- Electrophysiological Phenomena
- Evoked Potentials
- Extracellular Fluid
- Eye Enucleation
- Interneurons
- Light
- Membrane Potentials
- Nerve Net
- Neural Pathways
- Neurobiology
- Neurons
- Neurophysiology
- Night Vision
- Noise
- Nonlinear Dynamics
- Normal Distribution
- Photic Stimulation
- Photons
- Photoreceptors
- Poisson Distribution
- Reaction Time
- Retina
- Retina--Diseases
- Retinal Ganglion Cells
- Retinal Neurons
- Signal Transduction
- Synapses
- Time Factors
- Vision
- Vision, Ocular
- Visual Fields
- Research
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Selected Grants
- In Vivo Modeling of Mitochondrial Complex I Deficiency in Retinal Ganglion Cells awarded by National Institutes of Health 2018 - 2023
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Revealing neural computations through combined optical and electrical recordings awarded by National Institutes of Health 2019 - 2021
- The structure and significance of correlated activity among retinal ganglion cells awarded by National Institutes of Health 2018 - 2020
- The Impact of Dopamine and Melatonin on light and circadian dependent response in the retina awarded by Ruth K. Broad Biomedical Research Foundation 2017 - 2019
- Light Adaptation and Circadian Modulation awarded by National Institutes of Health 2014 - 2019
- Analyses of retinal circuits after rod rescue in a mouse model of human blindness awarded by University of Southern California 2016 - 2018
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Mapping the Functional Connectivity of the Mammalian Retina awarded by Whitehall Foundation, Inc. 2015 - 2017
- Neurochemical Pathyways in the Inner Retina awarded by University of California - Los Angeles 2014 - 2016
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Grove, JCR, Hirano, AA, de Los Santos, J, McHugh, CF, Purohit, S, Field, GD, Brecha, NC, and Barnes, S. "Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina." Plos Biology 17, no. 4 (April 2019): e3000200-null. Full Text
- Kling, A, Field, GD, Brainard, DH, and Chichilnisky, EJ. "Probing Computation in the Primate Visual System at Single-Cone Resolution." Annual Review of Neuroscience (March 11, 2019). Full Text Open Access Copy
- Field, GD, Uzzell, V, Chichilnisky, EJ, and Rieke, F. "Temporal resolution of single-photon responses in primate rod photoreceptors and limits imposed by cellular noise." Journal of Neurophysiology 121, no. 1 (January 2019): 255-268. Full Text Open Access Copy
- Johnson, EN, Westbrook, T, Shayesteh, R, Chen, EL, Schumacher, JW, Fitzpatrick, D, and Field, GD. "Distribution and diversity of intrinsically photosensitive retinal ganglion cells in tree shrew." The Journal of Comparative Neurology 527, no. 1 (January 2019): 328-344. Full Text Open Access Copy
- Ravi, S, Ahn, D, Greschner, M, Chichilnisky, EJ, and Field, GD. "Pathway-Specific Asymmetries between ON and OFF Visual Signals." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 38, no. 45 (November 2018): 9728-9740. Full Text
- Yao, X, Cafaro, J, McLaughlin, AJ, Postma, FR, Paul, DL, Awatramani, G, and Field, GD. "Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells." Neuron 100, no. 1 (October 2018): 216-228.e6. Full Text Open Access Copy
- Ray, TA, Roy, S, Kozlowski, C, Wang, J, Cafaro, J, Hulbert, SW, Wright, CV, Field, GD, and Kay, JN. "Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact." Elife 7 (April 3, 2018). Full Text Open Access Copy
- Solomon, AM, Westbrook, T, Field, GD, and McGee, AW. "Nogo receptor 1 is expressed by nearly all retinal ganglion cells." Plos One 13, no. 5 (January 2018): e0196565-null. Full Text Open Access Copy
- Sethuramanujam, S, Yao, X, deRosenroll, G, Briggman, KL, Field, GD, and Awatramani, GB. ""Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit." Neuron 96, no. 5 (December 2017): 1099-1111.e3. Full Text Open Access Copy
- Yu, W-Q, Grzywacz, NM, Lee, E-J, and Field, GD. "Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats." Journal of neurophysiology 118, no. 1 (July 2017): 434-454. Full Text
- Field, GD, and Sampath, AP. "Behavioural and physiological limits to vision in mammals." Philosophical transactions of the Royal Society of London. Series B, Biological sciences 372, no. 1717 (April 2017). (Review) Full Text
- Greschner, M, Heitman, AK, Field, GD, Li, PH, Ahn, D, Sher, A, Litke, AM, and Chichilnisky, EJ. "Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging." Current Biology : Cb 26, no. 15 (August 2016): 1935-1942. Full Text Open Access Copy
- Freeman, J, Field, GD, Li, PH, Greschner, M, Gunning, DE, Mathieson, K, Sher, A, Litke, AM, Paninski, L, Simoncelli, EP, and Chichilnisky, EJ. "Mapping nonlinear receptive field structure in primate retina at single cone resolution." Elife 4 (October 30, 2015). Full Text Open Access Copy
- Li, PH, Gauthier, JL, Schiff, M, Sher, A, Ahn, D, Field, GD, Greschner, M, Callaway, EM, Litke, AM, and Chichilnisky, EJ. "Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 35, no. 11 (March 2015): 4663-4675. Full Text Open Access Copy
- Li, PH, Field, GD, Greschner, M, Ahn, D, Gunning, DE, Mathieson, K, Sher, A, Litke, AM, and Chichilnisky, EJ. "Retinal representation of the elementary visual signal." Neuron 82, no. 2 (April 16, 2014): 500-null. Full Text Open Access Copy
- Greschner, M, Field, GD, Li, PH, Schiff, ML, Gauthier, JL, Ahn, D, Sher, A, Litke, AM, and Chichilnisky, EJ. "A polyaxonal amacrine cell population in the primate retina." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 34, no. 10 (March 2014): 3597-3606. Full Text Open Access Copy
- Li, PH, Field, GD, Greschner, M, Ahn, D, Gunning, DE, Mathieson, K, Sher, A, Litke, AM, and Chichilnisky, EJ. "Retinal representation of the elementary visual signal." Neuron 81, no. 1 (January 2014): 130-139. Full Text Open Access Copy
- Sadeghi, K, Gauthier, JL, Field, GD, Greschner, M, Agne, M, Chichilnisky, EJ, and Paninski, L. "Monte Carlo methods for localization of cones given multielectrode retinal ganglion cell recordings." Network (Bristol, England) 24, no. 1 (January 2013): 27-51. Full Text Open Access Copy
- Doi, E, Gauthier, JL, Field, GD, Shlens, J, Sher, A, Greschner, M, Machado, TA, Jepson, LH, Mathieson, K, Gunning, DE, Litke, AM, Paninski, L, Chichilnisky, EJ, and Simoncelli, EP. "Efficient coding of spatial information in the primate retina." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 32, no. 46 (November 2012): 16256-16264. Full Text Open Access Copy
- Greschner, M, Shlens, J, Bakolitsa, C, Field, GD, Gauthier, JL, Jepson, LH, Sher, A, Litke, AM, and Chichilnisky, EJ. "Correlated firing among major ganglion cell types in primate retina." The Journal of Physiology 589, no. Pt 1 (January 2011): 75-86. Full Text Open Access Copy
- Conway, BR, Chatterjee, S, Field, GD, Horwitz, GD, Johnson, EN, Koida, K, and Mancuso, K. "Advances in Color Science: From Retina to Behavior (vol 30, pg 14955, 2010)." Journal of Neuroscience 30, no. 49 (December 8, 2010). Open Access Copy Link to Item
- Conway, BR, Chatterjee, S, Field, GD, Horwitz, GD, Johnson, EN, Koida, K, and Mancuso, K. "Advances in color science: From retina to behavior (The Journal of Neuroscience (2010) (14955-14963))." Journal of Neuroscience 30, no. 49 (December 8, 2010). Open Access Copy
- Conway, BR, Chatterjee, S, Field, GD, Horwitz, GD, Johnson, EN, Koida, K, and Mancuso, K. "Advances in color science: from retina to behavior." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 45 (November 2010): 14955-14963. (Review) Full Text Open Access Copy
- Field, GD, Gauthier, JL, Sher, A, Greschner, M, Machado, TA, Jepson, LH, Shlens, J, Gunning, DE, Mathieson, K, Dabrowski, W, Paninski, L, Litke, AM, and Chichilnisky, EJ. "Functional connectivity in the retina at the resolution of photoreceptors." Nature 467, no. 7316 (October 2010): 673-677. Full Text Open Access Copy
- Okawa, H, Miyagishima, KJ, Arman, AC, Hurley, JB, Field, GD, and Sampath, AP. "Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity." The Journal of Physiology 588, no. Pt 11 (June 2010): 1947-1960. Full Text Open Access Copy
- Field, GD, Greschner, M, Gauthier, JL, Rangel, C, Shlens, J, Sher, A, Marshak, DW, Litke, AM, and Chichilnisky, EJ. "High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina." Nature Neuroscience 12, no. 9 (September 2009): 1159-1164. Full Text Open Access Copy
- Gauthier, JL, Field, GD, Sher, A, Greschner, M, Shlens, J, Litke, AM, and Chichilnisky, EJ. "Receptive fields in primate retina are coordinated to sample visual space more uniformly." PLoS biology 7, no. 4 (April 2009): e1000063-. Full Text
- Gauthier, JL, Field, GD, Sher, A, Shlens, J, Greschner, M, Litke, AM, and Chichilnisky, EJ. "Uniform signal redundancy of parasol and midget ganglion cells in primate retina." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 14 (April 2009): 4675-4680. Full Text
- Shlens, J, Field, GD, Gauthier, JL, Greschner, M, Sher, A, Litke, AM, and Chichilnisky, EJ. "The structure of large-scale synchronized firing in primate retina." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 15 (April 2009): 5022-5031. Full Text
- Gauthier, JL, Field, GD, Sher, A, Greschner, M, Shlens, J, Litke, AM, and Chichilnisky, EJ. "Receptive fields in primate retina are coordinated to sample visual space more uniformly." PLoS Biology 7, no. 4 (2009): 0747-0755. Full Text
- Shlens, J, Field, GD, Gauthier, JL, Grivich, MI, Petrusca, D, Sher, A, Litke, AM, and Chichilnisky, EJ. "The structure of multi-neuron firing patterns in primate retina (Journal of Neuroscience (August 9, 2006) (8254-8266))." Journal of Neuroscience 28, no. 5 (January 30, 2008).
- Shlens, J, Field, GD, Gauthier, JL, Grivich, MI, Petrusca, D, Sher, A, Litke, AM, and Chichilnisky, EJ. "The structure of multi-neuron firing patterns in primate retina (vol 26, pg 8254, 2006)." Journal of Neuroscience 28, no. 5 (January 30, 2008). Link to Item
- Field, GD, Sher, A, Gauthier, JL, Greschner, M, Shlens, J, Litke, AM, and Chichilnisky, EJ. "Spatial properties and functional organization of small bistratified ganglion cells in primate retina." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, no. 48 (November 2007): 13261-13272. Full Text
- Petrusca, D, Grivich, MI, Sher, A, Field, GD, Gauthier, JL, Greschner, M, Shlens, J, Chichilnisky, EJ, and Litke, AM. "Identification and characterization of a Y-like primate retinal ganglion cell type." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, no. 41 (October 2007): 11019-11027. Full Text
- Field, GD, and Chichilnisky, EJ. "Information processing in the primate retina: circuitry and coding." Annual Review of Neuroscience 30 (January 2007): 1-30. (Review) Full Text
- Shlens, J, Field, GD, Gauthier, JL, Grivich, MI, Petrusca, D, Sher, A, Litke, AM, and Chichilnisky, EJ. "The structure of multi-neuron firing patterns in primate retina." The Journal of neuroscience : the official journal of the Society for Neuroscience 26, no. 32 (August 2006): 8254-8266. Full Text
- Field, GD, Sampath, AP, and Rieke, F. "Retinal processing near absolute threshold: from behavior to mechanism." Annual review of physiology 67 (January 2005): 491-514. (Review) Full Text
- Field, GD, and Rieke, F. "Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors." Neuron 35, no. 4 (August 2002): 733-747. Full Text
- Field, GD, and Rieke, F. "Nonlinear signal transfer from mouse rods to bipolar cells and implications for visual sensitivity." Neuron 34, no. 5 (May 2002): 773-785. Full Text
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Conference Papers
- Pahlberg, J, Wang, T, Cafaro, J, Field, GD, Sampath, AP, and Chen, J. "Analyses Of Retinal Circuits After Rod Rescue In A Mouse Model Of Human Blindness." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Seattle, WA. May 1, 2016 - May 5, 2016.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, September 1, 2016. Link to Item
- Field, GD, Gauthier, JL, Greschner, M, Sher, A, Jepson, L, Litke, AM, and Chichilnisky, EJ. "Retinal Ganglion Cell Nonlinear Subunit Structure at Single-Cone Resolution." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010. Link to Item
- Field, GD, and Rieke, F. "Reproducibility of the single photon response in mammalian photoreceptors." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. FT LAUDERDALE, FLORIDA. May 5, 2002 - May 10, 2002.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, May 1, 2002. Link to Item
- Field, GD, Chichilnisky, EJ, and Rieke, F. "Signal and noise in mammalian rods and the implications for retinal processing." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, March 15, 2001. Link to Item
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- Teaching & Mentoring
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Recent Courses
- NEUROBIO 793: Research in Neurobiology 2019
- NEUROSCI 496: Research Independent Study 4 2019
- NEUROBIO 795: Special Topics in Neuroscience 2018
- NEUROSCI 494: Research Independent Study 2 2018
- NEUROSCI 495: Research Independent Study 3 2018
- NEUROBIO 720D: Circuits and Computation 2017
- NEUROSCI 493: Research Independent Study 1 2017
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Advising & Mentoring
- I primarily mentor Ph.D. candidates in the Neurobiology Graduate Program. I provide training opportunities for postdoctoral fellows. I also mentor exceptionally talented undergraduate neuroscience majors looking for research opportunities in neurobiology, vision science, or retinal physiology.
Available to mentor:
- PhD
- Post-Doc
- Undergraduate
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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