Francis Ali-Osman | Scholars@Duke

Francis Ali-Osman
Margaret Harris and David Silverman Professor of Neuro-Oncology Research

Current Appointments & Affiliations

Margaret Harris and David Silverman Professor of Neuro-Oncology Research, Neurosurgery, Neuro-Oncology, Neurosurgery 2004
Professor Emeritus in Neurosurgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003

Contact Information

199 Medical Science Research B, Durham, NC 27710
Box 3156 Med Ctr, Durham, NC 27710
francis.aliosman@duke.edu (919) 681-5769

Background
Education, Training, & Certifications
- D.Sc., Free University of Berlin (Germany) 1982
Duke Appointment History
- Professor in Pathology, Pathology, Clinical Science Departments 2004 - 2018
- Professor in Neurosurgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2017 - 2018
- Professor of Surgery, Surgery, Surgical Sciences, Surgery 2004 - 2017
- Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2003
Expertise
Global Scholarship
- Research
  - Ghana (Country)
Research
Selected Grants
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- P53-dependent GSTP1 Gene Regulation and Glioma Drug Resistance awarded by National Institutes of Health 2010 - 2015
- Protein Kinase C and GSTP1 interactions in glioma drug resistance awarded by National Institutes of Health 2008 - 2014
- NCI Howard Temin Award (K01) Transition awarded by National Institutes of Health 2006 - 2012
- Novel Targeted Therapeutics for CNS Malignancies awarded by National Institutes of Health 2006 - 2011
- Radionuclide-based Molecular Imaging of the DNA Repair Protein AGT awarded by National Institutes of Health 2009 - 2011
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- DNA Methylation and GSTP1 Gene Regulation in Gliomas awarded by National Institutes of Health 2002 - 2008
- Planning a Duke Academic Public Private Partnership Program (AP4) Center awarded by National Cancer Institute 2004 - 2006
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Amirian, E Susan, Quinn T. Ostrom, Georgina N. Armstrong, Rose K. Lai, Xiangjun Gu, Daniel I. Jacobs, Ali Jalali, et al. “Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 28, no. 3 (March 2019): 555–62. https://doi.org/10.1158/1055-9965.epi-18-0702.
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  - Erdal, Serap, Bridget J. McCarthy, Natalia Gurule, Marianne Berwick, Emily Gonzales, Johanna Byrd, Kristina Flores, et al. “Application of mutagen sensitivity assay in a glioma case-control study..” Toxicology Reports 5 (January 9, 2018): 183–88. https://doi.org/10.1016/j.toxrep.2017.12.010.
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  - Madala, Hanumantha Rao, Surendra R. Punganuru, Francis Ali-Osman, Ruiwen Zhang, and Kalkunte S. Srivenugopal. “Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts..” Oncotarget 9, no. 3 (January 2018): 3459–82. https://doi.org/10.18632/oncotarget.23320.
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  - Melin, Beatrice S., Jill S. Barnholtz-Sloan, Margaret R. Wrensch, Christoffer Johansen, Dora Il’yasova, Ben Kinnersley, Quinn T. Ostrom, et al. “Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors..” Nature Genetics 49, no. 5 (May 2017): 789–94. https://doi.org/10.1038/ng.3823.
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  - Paranjpe, Ameya, Nathan I. Bailey, Santhi Konduri, George C. Bobustuc, Francis Ali-Osman, Mohd A. Yusuf, Surendra R. Punganuru, et al. “New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy..” Journal of Biomedical Research 30, no. 5 (September 2016): 393–410. https://doi.org/10.7555/JBR.30.20160040.
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  - Amirian, E Susan, Michael E. Scheurer, Renke Zhou, Margaret R. Wrensch, Georgina N. Armstrong, Daniel Lachance, Sara H. Olson, et al. “History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC)..” Cancer Medicine 5, no. 6 (June 2016): 1352–58. https://doi.org/10.1002/cam4.682.
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  - Amirian, E Susan, Renke Zhou, Margaret R. Wrensch, Sara H. Olson, Michael E. Scheurer, Dora Il’yasova, Daniel Lachance, et al. “Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 25, no. 2 (February 2016): 282–90. https://doi.org/10.1158/1055-9965.EPI-15-0847.
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  - Amirian, E Susan, Georgina N. Armstrong, Renke Zhou, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Dora Il’yasova, et al. “The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium..” American Journal of Epidemiology 183, no. 2 (January 2016): 85–91. https://doi.org/10.1093/aje/kwv235.
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  - Okamura, Tatsunori, Gamil Antoun, Stephen T. Keir, Henry Friedman, Darell D. Bigner, and Francis Ali-Osman. “Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells..” The Journal of Biological Chemistry 290, no. 52 (December 2015): 30866–78. https://doi.org/10.1074/jbc.M115.656140.
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  - Brown, Kristine E., Gustavo Chagoya, Shawn G. Kwatra, Timothy Yen, Stephen T. Keir, Mary Cooter, Katherine A. Hoadley, et al. “Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development..” Journal of Neurochemistry 133, no. 5 (June 2015): 730–38. https://doi.org/10.1111/jnc.13032.
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  - Jalali, Ali, E Susan Amirian, Matthew N. Bainbridge, Georgina N. Armstrong, Yanhong Liu, Spyros Tsavachidis, Shalini N. Jhangiani, et al. “Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium..” Scientific Reports 5 (February 5, 2015). https://doi.org/10.1038/srep08278.
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  - Bainbridge, Matthew N., Georgina N. Armstrong, M Monica Gramatges, Alison A. Bertuch, Shalini N. Jhangiani, Harsha Doddapaneni, Lora Lewis, et al. “Germline mutations in shelterin complex genes are associated with familial glioma..” J Natl Cancer Inst 107, no. 1 (January 2015). https://doi.org/10.1093/jnci/dju384.
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  - Brown, K. E., G. Chagoya, S. G. Kwatra, T. Yen, S. T. Keir, M. Cooter, K. A. Hoadley, et al. “Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: Implications for drug development.” Journal of Neurochemistry 133, no. 5 (2015): 730–38. https://doi.org/10.1111/jnc.13032.
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  - Lidsky, Michael, Gamil Antoun, Paul Speicher, Bartley Adams, Ryan Turley, Christi Augustine, Douglas Tyler, and Francis Ali-Osman. “Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells..” The Journal of Biological Chemistry 289, no. 40 (October 2014): 27714–26. https://doi.org/10.1074/jbc.M113.532432.
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  - Paranjpe, Ameya, Ruiwen Zhang, Francis Ali-Osman, George C. Bobustuc, and Kalkunte S. Srivenugopal. “Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage..” Carcinogenesis 35, no. 3 (March 2014): 692–702. https://doi.org/10.1093/carcin/bgt366.
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  - Kinev, Alexander V., Vrad Levering, Kenneth Young, Francis Ali-Osman, George A. Truskey, Mark W. Dewhirst, and Dora Il’yasova. “Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose..” Cancer Invest 31, no. 5 (June 2013): 359–64. https://doi.org/10.3109/07357907.2013.789903.
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  - “Correction.” Cancer Science 104, no. 2 (February 2013): 274–274. https://doi.org/10.1111/cas.12109.
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  - Yang, W., L. Wang, G. Roehn, R. D. Pearlstein, F. Ali-Osman, H. Pan, R. Goldbrunner, M. Krantz, C. Harms, and W. Paschen. “Small ubiquitin-like modifier 1-3 is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.” Cancer Science 104, no. 1 (2013): 70–77. https://doi.org/10.1111/cas.12047.
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  - Yang, Wei, Liangli Wang, Gabriele Roehn, Robert D. Pearlstein, Francis Ali-Osman, Hongjie Pan, Roland Goldbrunner, Matthew Krantz, Christoph Harms, and Wulf Paschen. “Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival..” Cancer Science 104, no. 1 (January 2013): 70–77. https://doi.org/10.1111/cas.12047.
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  - Okamura, Tatsunori, and Francis Ali-Osman. “Abstract 2162: EGFR-induced interaction of GSTP1 with the SH2-domain of Grb2 enhances Ras downstream activation in human glioma cells.” Cancer Research 72, no. 8 Supplement (April 15, 2012): 2162–2162. https://doi.org/10.1158/1538-7445.am2012-2162.
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  - Turley, Ryan S., Michael E. Lidsky, Douglas S. Tyler, and Francis Ali-Osman. “Abstract 2012: MAP kinase activation and suppression of anti-apoptotic Bcl-2 family members are associated with induction of apoptotic death in melanoma cells following down-regulation of glutathione S-transferase P1.” Cancer Research 72, no. 8 Supplement (April 15, 2012): 2012–2012. https://doi.org/10.1158/1538-7445.am2012-2012.
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  - Lachance, Daniel H., Ping Yang, Derek R. Johnson, Paul A. Decker, Thomas M. Kollmeyer, Lucie S. McCoy, Terri Rice, et al. “Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking..” American Journal of Epidemiology 174, no. 5 (September 2011): 574–81. https://doi.org/10.1093/aje/kwr124.
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  - Cao, Xinyu, Mark Dewhirst, Francis Ali-Osman, and Hui-Wen Lo. “Abstract 2337: Defining significance of the novel tGLI1 transcription factor in cancer growth and progression.” Cancer Research 71, no. 8 Supplement (April 15, 2011): 2337–2337. https://doi.org/10.1158/1538-7445.am2011-2337.
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  - Okamura, Tatsunori, and Francis Ali-osman. “Abstract 703: GSTP1 inhibition of HSP27 phosphorylation contributes to glioma drug resistance.” Cancer Research 71, no. 8 Supplement (April 15, 2011): 703–703. https://doi.org/10.1158/1538-7445.am2011-703.
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  - Turley, Ryan S., Jiewu Liu, Douglas Tyler, and Francis Ali-Osman. “Abstract 1635: Short hairpin RNA-mediated transcriptional suppression of glutathione S-transferase P1 suppresses growth and induces apoptosis through altered MAP kinase signaling in melanoma cells.” Cancer Research 71, no. 8 Supplement (April 15, 2011): 1635–1635. https://doi.org/10.1158/1538-7445.am2011-1635.
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  - Cao, Xinyu, Hu Zhu, Francis Ali-Osman, and Hui-Wen Lo. “EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis..” Molecular Cancer 10 (March 9, 2011). https://doi.org/10.1186/1476-4598-10-26.
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  - McCarthy, Bridget J., Kristin Rankin, Dora Il’yasova, Serap Erdal, Nicholas Vick, Francis Ali-Osman, Darell D. Bigner, and Faith Davis. “Assessment of type of allergy and antihistamine use in the development of glioma..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 20, no. 2 (February 2011): 370–78. https://doi.org/10.1158/1055-9965.EPI-10-0948.
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  - Advani, Anjali S., Mazyar Shadman, Francis Ali-Osman, Andrew Barker, Lisa Rybicki, Matt Kalaycio, Mikkael A. Sekeres, et al. “A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse..” Clinical Lymphoma, Myeloma & Leukemia 10, no. 6 (December 2010): 473–76. https://doi.org/10.3816/clml.2010.n.082.
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  - Jones, Lee W., Francis Ali-Osman, Eric Lipp, Jennifer E. Marcello, Bridget McCarthy, Lucie McCoy, Terri Rice, Margaret Wrensch, and Dora Il’yasova. “Association between body mass index and mortality in patients with glioblastoma mutliforme..” Cancer Causes & Control : Ccc 21, no. 12 (December 2010): 2195–2201. https://doi.org/10.1007/s10552-010-9639-x.
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  - Cui, Bo, Stewart P. Johnson, Nancy Bullock, Francis Ali-Osman, Darell D. Bigner, and Henry S. Friedman. “Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells..” Journal of Biomedical Research 24, no. 6 (November 2010): 424–35. https://doi.org/10.1016/S1674-8301(10)60057-7.
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  - Singh, Simendra, Tatsunori Okamura, and Francis Ali-Osman. “Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells..” Biochemical Pharmacology 80, no. 9 (November 2010): 1343–55. https://doi.org/10.1016/j.bcp.2010.07.019.
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  - Toshimitsu, Hiroaki, Yasunori Yoshimoto, Christina K. Augustine, James C. Padussis, Jin S. Yoo, M. Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma..” Annals of Surgical Oncology 17, no. 8 (August 2010): 2247–54. https://doi.org/10.1245/s10434-010-0971-x.
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  - Zhu, Hu, Xinyu Cao, Francis Ali-Osman, Stephen Keir, and Hui-Wen Lo. “EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity..” Cancer Letters 294, no. 1 (August 2010): 101–10. https://doi.org/10.1016/j.canlet.2010.01.028.
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  - Augustine, Christina K., Hiroaki Toshimitsu, Sin-Ho Jung, Patricia A. Zipfel, Jin S. Yoo, Yasunori Yoshimoto, M Angelica Selim, et al. “Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy..” Molecular Cancer Therapeutics 9, no. 7 (July 2010): 2090–2101. https://doi.org/10.1158/1535-7163.mct-10-0073.
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  - Crout, Christopher A., Liang-Piu Koh, Jon P. Gockerman, Joseph O. Moore, Carlos Decastro, Gwynn D. Long, Louis Diehl, et al. “Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy..” Cancer Investigation 28, no. 6 (July 2010): 654–60. https://doi.org/10.3109/07357901003631015.
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  - Augustine, Christina K., Sin-Ho Jung, Insuk Sohn, Jin Soo Yoo, Yasunori Yoshimoto, John A. Olson, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma..” Molecular Cancer Therapeutics 9, no. 4 (April 6, 2010): 779–90. https://doi.org/10.1158/1535-7163.mct-09-0764.
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  - Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes..” Molecular Cancer Research : Mcr 8, no. 2 (February 9, 2010): 232–45. https://doi.org/10.1158/1541-7786.MCR-09-0391.
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  - Lo, Hui-Wen, Hu Zhu, Xinyu Cao, Amy Aldrich, and Francis Ali-Osman. “A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion..” Cancer Research 69, no. 17 (September 2009): 6790–98. https://doi.org/10.1158/0008-5472.CAN-09-0886.
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  - Okamura, Tatsunori, Simendra Singh, John Buolamwini, Timothy Haystead, Henry Friedman, Darell Bigner, and Francis Ali-Osman. “Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor..” J Biol Chem 284, no. 25 (June 19, 2009): 16979–89. https://doi.org/10.1074/jbc.M808153200.
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  - Cui, B., S. P. Johnson, N. Bullock, F. Ali-Osman, D. D. Bigner, and H. S. Friedman. “Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway..” Molecular Pharmacology 75, no. 6 (June 2009): 1356–63. https://doi.org/10.1124/mol.108.053124.
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  - Antoun, Gamil, and Francis Ali-Osman. “Structural and functional analysis of Nucleophosmin I (NPM1) in human malignant gliomas.” Cancer Research 69 (May 1, 2009).
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  - Okamura, Tatsunori, and Francis Ali-Osman. “Phosphorylation of a C-terminal tyrosine of GSTP1 by EGFR dissociates GSTP1 from the GSTP1-JNK complex leading to JNK activation in glioblastoma cells.” Cancer Research 69 (May 1, 2009).
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  - Singh, Simendra, and Francis Ali-Osman. “Serine-phosphorylation of the GSTP1 protein by PKC\#945; increase GSTP1-mediated cisplatin metabolism and descrease cisplatin-induced DNA interstrand cross link formation and cisplatin sensitivity in human glioma cells.” Cancer Research 69 (May 1, 2009).
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  - Zhu, Hu, Xinyu Cao, Amy Aldrich, Francis Ali-Osman, and Hui-Wen Lo. “EGFR and EGFRvIII attenuate drug-induced apoptosis in glioblastomas via mitochondrial transport and interaction with pro-apoptotic proteins:A novel EGFR/EGFRvIII-mediated mechanism in drug resistance.” Cancer Research 69 (May 1, 2009).
  - Il’yasova, Dora, Bridget McCarthy, Jennifer Marcello, Joellen M. Schildkraut, Patricia G. Moorman, Bhuma Krishnamachari, Francis Ali-Osman, Darell D. Bigner, and Faith Davis. “Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 18, no. 4 (April 2009): 1232–38. https://doi.org/10.1158/1055-9965.EPI-08-0995.
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  - Okamura, Tatsunori, Simendrah Singh, John K. Buolamwini, Henry S. Friedman, Darell D. Bigner, and Francis Ali-Osman. “EGF RECEPTOR TYROSINE KINASE MEDIATES A NOVEL PATHWAY OF DRUG RESISTANCE IN MALIGNANT GLIOMAS VIA TYROSINE PHOSPHORYLATION AND FUNCTIONAL ACTIVATION OF GLUTATHIONE S-TRANSFERASE P1.” Neuro Oncology 11, no. 2 (April 1, 2009): 218–218.
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  - Augustine, Christina K., Jin Soo Yoo, Anil Potti, Yasunori Yoshimoto, Patricia A. Zipfel, Henry S. Friedman, Joseph R. Nevins, Francis Ali-Osman, and Douglas S. Tyler. “Genomic and molecular profiling predicts response to temozolomide in melanoma..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 15, no. 2 (January 2009): 502–10. https://doi.org/10.1158/1078-0432.ccr-08-1916.
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  - Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 14, no. 19 (October 2008): 6042–54. https://doi.org/10.1158/1078-0432.CCR-07-4923.
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  - Maxwell, Jill A., Stewart P. Johnson, Roger E. McLendon, David W. Lister, Krystle S. Horne, Ahmed Rasheed, Jennifer A. Quinn, et al. “Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 14, no. 15 (August 2008): 4859–68. https://doi.org/10.1158/1078-0432.CCR-07-4807.
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  - Xie, Tong-Xin, Kenneth D. Aldape, Weida Gong, Takao Kanzawa, Dima Suki, Seiji Kondo, Frederick Lang, Francis Ali-Osman, Raymond Sawaya, and Suyun Huang. “Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor..” International Journal of Oncology 33, no. 1 (July 2008): 5–15.
  - Augustine, C. K., S. Jung, A. Potti, I. Sohn, J. S. Yoo, P. Zipfel, J. Olson, F. Ali-Osman, J. R. Nevins, and D. S. Tyler. “Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma..” J Clin Oncol 26, no. 15_suppl (May 20, 2008).
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  - Augustine, C. K., S. Jung, A. Potti, I. Sohn, J. S. Yoo, P. Zipfel, J. Olson, F. Ali-Osman, J. R. Nevins, and D. S. Tyler. “Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 9077–9077. https://doi.org/10.1200/jco.2008.26.15_suppl.9077.
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  - Lo, Hui-Wen, Lisa Stephenson, Xinyu Cao, Mira Milas, Raphael Pollock, and Francis Ali-Osman. “Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene..” Mol Cancer Res 6, no. 5 (May 2008): 843–50. https://doi.org/10.1158/1541-7786.MCR-07-2105.
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  - Lo, Hui-Wen, and Francis Ali-Osman. “Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance..” Curr Opin Pharmacol 7, no. 4 (August 2007): 367–74. https://doi.org/10.1016/j.coph.2007.06.009.
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  - Tew, Kenneth D. “Redox pathways in cancer drug discovery..” Current Opinion in Pharmacology 7, no. 4 (August 2007): 353–54. https://doi.org/10.1016/j.coph.2007.07.003.
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  - Yoshimoto, Yasunori, Christina K. Augustine, Jin S. Yoo, Patricia A. Zipfel, M Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents..” Molecular Cancer Therapeutics 6, no. 5 (May 4, 2007): 1492–1500. https://doi.org/10.1158/1535-7163.mct-06-0718.
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  - Maxwell, Jill A., Stewart P. Johnson, Jennifer A. Quinn, Roger E. McLendon, Francis Ali-Osman, Allan H. Friedman, James E. Herndon, et al. “Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma..” Molecular Cancer Therapeutics 5, no. 10 (October 2006): 2531–39. https://doi.org/10.1158/1535-7163.mct-06-0106.
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  - Cheng, C Lynn, Stewart P. Johnson, Stephen T. Keir, Jennifer A. Quinn, Francis Ali-Osman, Csaba Szabo, Hongshan Li, et al. “Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft..” Molecular Cancer Therapeutics 4, no. 9 (September 2005): 1364–68. https://doi.org/10.1158/1535-7163.mct-05-0128.
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  - Shou, J., K. S. Srivenugopal, S. R. S. Mullapudi, F. F. Lang, J. S. Rao, and F. Ali-Osman. “Erratum: Enforced expression of wild-type p53 curtails the transcription of the O⁶-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents (Clinical Cancer Research (May 1, 2001) 7 (1398-1409)).” Clinical Cancer Research 11, no. 6 (March 15, 2005). https://doi.org/10.1158/1078-0432.CCR-11-6-COR.
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  - Shou, J., K. S. Srivenugopal, S. R. S. Mullapudi, F. F. Lang, J. S. Rao, and F. Ali-Osman. “Article on the enforced expression of wild-type p53 and the transcription of the O-6 -methylguanine-DNA methyltransferase gene (vol 7, pg 1398, 2001).” Clinical Cancer Research 11, no. 6 (March 15, 2005): 2449–2449.
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  - Lo, Hui-Wen, Gamil R. Antoun, and Francis Ali-Osman. “The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells..” Cancer Research 64, no. 24 (December 2004): 9131–38. https://doi.org/10.1158/0008-5472.can-04-0283.
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  - Okcu, M Fatih, Mano Selvan, Li-E Wang, Linda Stout, Rodrigo Erana, Gladstone Airewele, Phyllis Adatto, et al. “Glutathione S-transferase polymorphisms and survival in primary malignant glioma..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 10, no. 8 (April 2004): 2618–25. https://doi.org/10.1158/1078-0432.ccr-03-0053.
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  - Xie, Tong-Xin, Daoyan Wei, Mingguang Liu, Allen C. Gao, Francis Ali-Osman, Raymond Sawaya, and Suyun Huang. “Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis..” Oncogene 23, no. 20 (April 2004): 3550–60. https://doi.org/10.1038/sj.onc.1207383.
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  - Barnette, Phillip, Rebecca Scholl, Mary Blandford, Linda Ballard, Alexander Tsodikov, Jalene Magee, Susana Williams, et al. “High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 13, no. 2 (February 2004): 304–13. https://doi.org/10.1158/1055-9965.epi-03-0178.
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  - Konduri, Santhi D., Kalkunte S. Srivenugopal, Niranjan Yanamandra, Dzung H. Dinh, William C. Olivero, Meena Gujrati, Donald C. Foster, et al. “Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells..” Oncogene 22, no. 29 (July 2003): 4509–16. https://doi.org/10.1038/sj.onc.1206695.
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  - Wang, Yunfei, Margaret R. Spitz, Matthew B. Schabath, Francis Ali-Osman, Hilario Mata, and Xifeng Wu. “Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study..” Lung Cancer (Amsterdam, Netherlands) 40, no. 1 (April 2003): 25–32. https://doi.org/10.1016/s0169-5002(02)00537-8.
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  - Konduri, S. D., K. S. Srivenugopal, N. Yanamandra, D. H. Dinh, W. C. Olivero, M. Gujrati, D. C. Foster, et al. “Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), in human glioma cells.” Oncogene 22, no. 29 (2003): 4509–16. https://doi.org/10.1038/sj.onc.1206695.
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  - Zheng, T., T. R. Holford, S. H. Zahm, P. H. Owens, P. Boyle, Y. Zhang, B. Zhang, J. P. Wise, L. P. Stephenson, and F. Ali-Osman. “Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk..” British Journal of Cancer 88, no. 1 (January 2003): 58–62. https://doi.org/10.1038/sj.bjc.6600708.
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  - Ishimoto, Tricia M., and Francis Ali-Osman. “Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli..” Pharmacogenetics 12, no. 7 (October 2002): 543–53. https://doi.org/10.1097/00008571-200210000-00006.
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  - Zheng, Tongzhang, Theodore R. Holford, Shelia H. Zahm, Patricia H. Owens, Peter Boyle, Yawei Zhang, John Pierce Wise, Lisa Pleasants Stephenson, and Francis Ali-Osman. “Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States)..” Cancer Causes & Control : Ccc 13, no. 7 (September 2002): 637–45. https://doi.org/10.1023/a:1019500109267.
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  - Srivenugopal, Kalkunte S., and Francis Ali-Osman. “The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein..” Oncogene 21, no. 38 (August 2002): 5940–45. https://doi.org/10.1038/sj.onc.1205762.
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  - Bacolod, Manny D., Stewart P. Johnson, Francis Ali-Osman, Paul Modrich, Nancy S. Bullock, O Michael Colvin, Darell D. Bigner, and Henry S. Friedman. “Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma..” Molecular Cancer Therapeutics 1, no. 9 (July 2002): 727–36.
  - Srivenugopal, Kalkunte S., Srinivas R. S. Mullapudi, and Francis Ali-Osman. “Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay..” Cancer Letters 181, no. 1 (July 2002): 87–93. https://doi.org/10.1016/s0304-3835(01)00823-0.
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  - Madden, R. M., K. W. Chan, L. P. Stephenson, and F. Ali-Osman. “Analysis and significance of the genetic polymorphism of the glutathione S-transferase P1 gene locus in pediatric tumors.” Pediatric Research 51, no. 4 (April 2002): 233A-233A.
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  - Konduri, Santhi D., Francis Ali Osman, Chilukuri N. Rao, Harish Srinivas, Niranjan Yanamandra, Anastasia Tasiou, Dzung H. Dinh, et al. “Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas..” Oncogene 21, no. 6 (January 2002): 921–28. https://doi.org/10.1038/sj.onc.1204983.
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  - Lo, Hui-Wen, and Francis Ali-Osman. “Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation..” Journal of Cellular Biochemistry 87, no. 1 (January 2002): 103–16. https://doi.org/10.1002/jcb.10275.
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  - Shou, Jiang, Francis Ali-Osman, Asha S. Multani, Sen Pathak, Paolo Fedi, and Kalkunte S. Srivenugopal. “Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA..” Oncogene 21, no. 6 (January 2002): 878–89. https://doi.org/10.1038/sj.onc.1205138.
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  - Mohanam, S., S. L. Jasti, S. R. Kondraganti, N. Chandrasekar, S. S. Lakka, Y. Kin, G. N. Fuller, et al. “Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells..” Oncogene 20, no. 28 (June 2001): 3665–73. https://doi.org/10.1038/sj.onc.1204480.
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  - Srivenugopal, K. S., J. Shou, S. R. Mullapudi, F. F. Lang, J. S. Rao, and F. Ali-Osman. “Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 7, no. 5 (May 2001): 1398–1409.
  - Lakka, S. S., R. Rajagopal, M. K. Rajan, P. M. Mohan, Y. Adachi, D. H. Dinh, W. C. Olivero, et al. “Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 7, no. 4 (April 2001): 1087–93.
  - Ali-Osman, F., K. Srivenugopal, and R. Sawaya. “The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents..” The New England Journal of Medicine 344, no. 9 (March 2001).
  - Buckner, J. C., and T. J. Moynihan. “The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents..” The New England Journal of Medicine 344, no. 9 (March 2001). https://doi.org/10.1056/nejm200103013440914.
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  - Lo, H. W., and F. Ali-Osman. “The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site.” Chemico Biological Interactions 133, no. 1–3 (February 28, 2001): 320–21.
  - Maugard, C. M., J. Charrier, A. Pitard, L. Campion, O. Akande, L. Pleasants, and F. Ali-Osman. “Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier..” International Journal of Cancer 91, no. 3 (February 2001): 334–39. https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1057>3.0.co;2-h.
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  - Kondraganti, S., S. Mohanam, S. K. Chintala, Y. Kin, S. L. Jasti, C. Nirmala, S. S. Lakka, et al. “Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion..” Cancer Research 60, no. 24 (December 2000): 6851–55.
  - Nirmala, C., S. L. Jasti, R. Sawaya, A. P. Kyritsis, S. D. Konduri, F. Ali-Osman, J. S. Rao, and S. Mohanam. “Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions..” International Journal of Cancer 88, no. 5 (December 2000): 766–71. https://doi.org/10.1002/1097-0215(20001201)88:5<766::aid-ijc13>3.0.co;2-y.
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  - Mullapudi, S. R., F. Ali-Osman, J. Shou, and K. S. Srivenugopal. “DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells..” The Biochemical Journal 351 Pt 2 (October 2000): 393–402. https://doi.org/10.1042/bj3510393.
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  - Ramachandran, S., P. R. Hoban, F. Ichii-Jones, L. Pleasants, F. Ali-Osman, J. T. Lear, A. G. Smith, et al. “Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours..” Pharmacogenetics 10, no. 6 (August 2000): 545–56. https://doi.org/10.1097/00008571-200008000-00008.
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  - Antoun, G., S. B. Baylin, and F. Ali-Osman. “DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA..” Journal of Cellular Biochemistry 77, no. 3 (April 2000): 372–81. https://doi.org/10.1002/(sici)1097-4644(20000601)77:3<372::aid-jcb3>3.0.co;2-p.
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  - Chandrasekar, N., S. Jasti, W. K. Alfred-Yung, F. Ali-Osman, D. H. Dinh, W. C. Olivero, M. Gujrati, et al. “Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions..” Clinical & Experimental Metastasis 18, no. 4 (January 2000): 337–42. https://doi.org/10.1023/a:1010833730407.
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  - Lakka, S. S., S. L. Jasti, A. P. Kyritsis, W. K. Yung, F. Ali-Osman, G. L. Nicolson, and J. S. Rao. “Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades..” Clinical & Experimental Metastasis 18, no. 3 (January 2000): 245–52. https://doi.org/10.1023/a:1006724826083.
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  - Srivenugopal, K. S., S. R. Mullapudi, J. Shou, T. K. Hazra, and F. Ali-Osman. “Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells..” Cancer Research 60, no. 2 (January 2000): 282–87.
  - Lo, H. W., and F. Ali-Osman. “Differential transactivation of the hGSTP1 promoter by individual direct/everted repeat retinoic acid response elements in intron 5 of the hGSTP1 gene.” Clinical Chemistry and Enzymology Communications 8, no. 4–6 (December 1, 1999): 293–302.
  - Ali-Osman, F., and J. Buolanwini. “Molecular modeling based design of novel anticancer therapeutics that target the active sites of polymorphic GSTP1 proteins..” Clinical Cancer Research 5 (November 1999): 3841S-3841S.
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  - Multani, A. S., M. Ozen, S. Sen, A. K. Mandal, J. E. Price, D. Fan, R. Radinsky, et al. “Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin..” Int J Oncol 15, no. 3 (September 1999): 423–29.
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  - Chan, J. Y., and F. Ali-Osman. “In vitro repair synthesis of BCNU-induced DNA damage..” Cancer Biochemistry Biophysics 16, no. 3 (October 1998): 273–86.
  - Ali-Osman, F., K. D. Tew, and R. C. Strange. “Special issue: Glutathione and glutathione-linked enzymes in human cancer and other diseases - Preface.” Chemico Biological Interactions 112 (April 24, 1998): XIII–XIV.
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  - Anderson, C. M., A. C. Buzaid, J. Sussman, J. J. Lee, F. Ali-Osman, P. G. Braunschweiger, C. Plager, et al. “Nitric oxide and neopterin levels and clinical response in stage III melanoma patients receiving concurrent biochemotherapy..” Melanoma Research 8, no. 2 (April 1998): 149–55.
  - Buzaid, A. C., F. Ali-Osman, N. Akande, E. A. Grimm, J. J. Lee, A. Bedikian, O. Eton, et al. “DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma..” Melanoma Research 8, no. 2 (April 1998): 145–48.
  - Keller, C., and F. Ali-Osman. “Translational inhibition of messenger RNA of the human pi class glutathione S-transferase by antisense oligodeoxyribonucleotides..” Chemico Biological Interactions 111–112 (April 1998): 307–23. https://doi.org/10.1016/s0009-2797(97)00168-3.
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  - Lo, H. W., and F. Ali-Osman. “Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line..” Chemico Biological Interactions 111–112 (April 1998): 91–102. https://doi.org/10.1016/s0009-2797(97)00153-1.
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  - Ali-Osman, F. “Antisense oligonucleotide downregulation of human glutathione S-transferase-PI gene expression for enhanced efficacy of cancer chemotherapy.” International Journal of Pediatric Hematology/Oncology 5, no. 1 (January 1, 1998): 48–49.
  - Lo, H. W., and F. Ali-Osman. “Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements..” J Biol Chem 272, no. 52 (December 26, 1997): 32743–49. https://doi.org/10.1074/jbc.272.52.32743.
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  - Ali-Osman, F., J. M. Brunner, T. M. Kutluk, and K. Hess. “Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 3, no. 12 Pt 1 (December 1997): 2253–61.
  - Ali-Osman, F., J. M. Brunner, T. M. Kutluk, and K. Hess. “Prognostic significance of glutathione S-transferase π expression and subcellular localization in human gliomas.” Clinical Cancer Research 3, no. 12 I (December 1, 1997): 2253–61.
  - Ali-Osman, F., J. M. Brunner, T. M. Kutluk, and K. Hess. “Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas.” Clinical Cancer Research 3, no. 12 (December 1997): 2253–61.
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  - Chintala, S. K., F. Ali-Osman, S. Mohanam, A. Rayford, Y. Go, Z. L. Gokaslan, E. Gagercas, et al. “Effect of cisplatin and BCNU on MMP-2 levels in human glioblastoma cell lines in vitro..” Clinical & Experimental Metastasis 15, no. 4 (July 1997): 361–67. https://doi.org/10.1023/a:1018442003163.
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  - Friedman, H. S., S. P. Johnson, Q. Dong, S. C. Schold, B. K. Rasheed, S. H. Bigner, F. Ali-Osman, et al. “Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft..” Cancer Research 57, no. 14 (July 1997): 2933–36.
  - Go, Y., S. K. Chintala, A. Rayford, E. Gagercas, F. Ali-Osman, B. Venkaiah, R. Sawaya, Z. Gokaslan, G. L. Nicolson, and J. S. Rao. “Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro..” Clinical & Experimental Metastasis 15, no. 4 (July 1997): 447–52. https://doi.org/10.1023/a:1018462507706.
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  - Srivenugopal, K. S., and F. Ali-Osman. “Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues..” Cancer Letters 117, no. 1 (July 1997): 105–11. https://doi.org/10.1016/s0304-3835(97)00210-3.
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  - Ali-Osman, F., O. Akande, G. Antoun, J. X. Mao, and J. Buolamwini. “Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins..” J Biol Chem 272, no. 15 (April 11, 1997): 10004–12. https://doi.org/10.1074/jbc.272.15.10004.
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  - Brandt, T. Y., and F. Ali-Osman. “Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells..” Toxicology and Applied Pharmacology 143, no. 1 (March 1997): 22–29. https://doi.org/10.1006/taap.1996.8010.
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  - Hare, C. B., G. B. Elion, O. M. Colvin, F. Ali-Osman, O. W. Griffith, W. P. Petros, S. Keir, S. L. Marcelli, D. D. Bigner, and H. S. Friedman. “Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft..” Cancer Chemotherapy and Pharmacology 40, no. 5 (January 1997): 409–14. https://doi.org/10.1007/s002800050678.
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  - OSMAN, F. A. “Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.” J. Biol. Chem. 272 (1997): 10004–12.
  - Srivenugopal, K. S., and F. Ali-Osman. “Coordinate up-regulation of cyclin-dependent kinase 4 and its inhibitor p16(INK4) in human glioma cells following chloroethylnitrosourea-induced DNA damage.” International Journal of Oncology 11, no. 6 (January 1, 1997): 1251–56.
  - Ali-Osman, F., G. Antoun, H. Wang, S. Rajagopal, and E. Gagucas. “Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells..” Molecular Pharmacology 49, no. 6 (June 1996): 1012–20.
  - Srivenugopal, K. S., and F. Ali-Osman. “Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells..” Oncogene 12, no. 9 (May 1996): 2029–34.
  - Ali-Osman, F. “Culture of human normal brain and malignant brain tumors for cellular, molecular, and pharmacological studies..” Methods in Molecular Medicine 2 (January 1996): 63–80. https://doi.org/10.1385/0-89603-335-x:63.
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  - Dong, Q., N. Bullock, F. Ali-Osman, O. M. Colvin, D. D. Bigner, and H. S. Friedman. “Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines..” Cancer Chemotherapy and Pharmacology 37, no. 3 (January 1996): 242–46. https://doi.org/10.1007/bf00688323.
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  - Moynihan, K., G. B. Elion, F. Ali-Osman, S. Marcelli, S. Keir, D. D. Bigner, and H. S. Friedman. “Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta..” Cancer Chemotherapy and Pharmacology 38, no. 4 (January 1996): 349–54. https://doi.org/10.1007/s002800050494.
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  - Srivenugopal, K. S., X. H. Yuan, H. S. Friedman, and F. Ali-Osman. “Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea..” Biochemistry 35, no. 4 (January 1996): 1328–34. https://doi.org/10.1021/bi9518205.
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  - Wei, Q., X. Xu, L. Cheng, R. J. Legerski, and F. Ali-Osman. “Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR..” Cancer Research 55, no. 21 (November 1995): 5025–29.
  - Spence, A. M., J. S. Rasey, L. Dwyer-Hansen, Z. Grunbaum, J. Livesey, L. Chin, N. Nelson, D. Stein, K. A. Krohn, and F. Ali-Osman. “Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates..” Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology 35, no. 3 (June 1995): 216–26. https://doi.org/10.1016/0167-8140(95)01543-p.
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  - Aggarwal, B. B., E. Pocsik, K. Totpal, and F. Ali-Osman. “Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene..” Febs Letters 357, no. 1 (January 1995): 1–6. https://doi.org/10.1016/0014-5793(94)01299-g.
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  - Ali-Osman, F., A. Rairkar, and P. Young. “Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells..” Cancer Biochemistry Biophysics 14, no. 4 (January 1995): 231–41.
  - Li, L., H. Yoo, F. F. Becker, F. Ali-Osman, and J. Y. Chan. “Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid..” Biochemical and Biophysical Research Communications 206, no. 2 (January 1995): 764–74. https://doi.org/10.1006/bbrc.1995.1108.
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  - Aggarwal, B. B., E. Pocsik, F. Ali-Osman, and K. Totpal. “Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor..” Febs Letters 354, no. 1 (October 1994): 12–16. https://doi.org/10.1016/0014-5793(94)01073-0.
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  - Buzaid, A. C., E. A. Grimm, F. Ali-Osman, S. Ring, O. Eton, N. E. Papadopoulos, A. Bedikian, C. Plager, S. S. Legha, and R. Benjamin. “Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results..” Melanoma Research 4, no. 5 (October 1994): 327–30.
  - Yoshida, M., A. R. Khokhar, Y. Kido, F. Ali-Osman, and Z. H. Siddik. “Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin..” Biochemical Pharmacology 48, no. 4 (August 1994): 793–99. https://doi.org/10.1016/0006-2952(94)90058-2.
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  - Friedman, H. S., M. E. Dolan, S. H. Kaufmann, O. M. Colvin, O. W. Griffith, R. C. Moschel, S. C. Schold, D. D. Bigner, and F. Ali-Osman. “Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan..” Cancer Research 54, no. 13 (July 1994): 3487–93.
  - Aggarwal, B. B., K. Totpal, F. Ali-Osman, R. J. Budde, and E. Pocsik. “pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor..” Febs Letters 345, no. 2–3 (May 1994): 219–24. https://doi.org/10.1016/0014-5793(94)00441-2.
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  - Pocsik, E., R. Mihalik, F. Ali-Osman, and B. B. Aggarwal. “Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response..” Journal of Cellular Biochemistry 54, no. 4 (April 1994): 453–64. https://doi.org/10.1002/jcb.240540412.
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  - Ali-Osman, F., M. S. Berger, A. Rairkar, and D. E. Stein. “Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy..” Journal of Cellular Biochemistry 54, no. 1 (January 1994): 11–19. https://doi.org/10.1002/jcb.240540103.
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  - Rao, J. S., P. A. Steck, P. Tofilon, D. Boyd, F. Ali-Osman, W. G. Stetler-Stevenson, L. A. Liotta, and R. Sawaya. “Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model..” Journal of Neuro Oncology 18, no. 2 (January 1994): 129–38. https://doi.org/10.1007/bf01050419.
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  - Sawaya, R., P. J. Tofilon, S. Mohanam, F. Ali-Osman, L. A. Liotta, W. G. Stetler-Stevenson, and J. S. Rao. “Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes..” International Journal of Cancer 56, no. 2 (January 1994): 214–18. https://doi.org/10.1002/ijc.2910560212.
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  - Ali-Osman, F., M. S. Berger, S. Rajagopal, A. Spence, and R. B. Livingston. “Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells..” Cancer Research 53, no. 23 (December 1993): 5663–68.
  - Ishikawa, T., and F. Ali-Osman. “Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance..” The Journal of Biological Chemistry 268, no. 27 (September 1993): 20116–25.
  - Mohanam, S., R. Sawaya, I. McCutcheon, F. Ali-Osman, D. Boyd, and J. S. Rao. “Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody..” Cancer Research 53, no. 18 (September 1993): 4143–47.
  - Sriram, R., and F. Ali-Osman. “Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line..” Biochemistry and Molecular Biology International 30, no. 6 (August 1993): 1053–60.
  - Silbergeld, D. L., M. R. Mayberg, M. S. Berger, F. Ali-Osman, W. A. Kelly, and C. M. Shaw. “Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations..” Journal of Neuro Oncology 16, no. 1 (April 1993): 39–46. https://doi.org/10.1007/bf01324833.
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  - Genka, S., J. Deutsch, U. H. Shetty, P. L. Stahle, V. John, I. M. Lieberburg, F. Ali-Osman, S. I. Rapoport, and N. H. Greig. “Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil..” Clinical & Experimental Metastasis 11, no. 2 (March 1993): 131–40. https://doi.org/10.1007/bf00114971.
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  - Spence, A. M., M. S. Berger, R. B. Livingston, F. Ali-Osman, and B. Griffin. “Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure..” Journal of Neuro Oncology 12, no. 2 (February 1992): 187–91. https://doi.org/10.1007/bf00172671.
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  - Silbergeld, D. L., F. Ali-Osman, and H. R. Winn. “Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells..” Journal of Neurosurgery 75, no. 4 (October 1991): 604–12. https://doi.org/10.3171/jns.1991.75.4.0604.
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  - Silbergeld, D. L., and F. Ali-Osman. “Isolation and characterization of microvessels from normal brain and brain tumors..” Journal of Neuro Oncology 11, no. 1 (August 1991): 49–55. https://doi.org/10.1007/bf00166997.
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  - Ali-Osman, F., D. E. Stein, and A. Renwick. “Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines..” Cancer Research 50, no. 21 (November 1990): 6976–80.
  - Ali-Osman, F., and D. Schofield. “Cellular and molecular studies in brain and nervous system oncology..” Current Opinion in Oncology 2, no. 4 (August 1990): 655–65.
  - Srivenugopal, K. S., and F. Ali-Osman. “Stimulation and inhibition of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced strand breaks and interstrand cross-linking in Col E1 plasmid deoxyribonucleic acid by polyamines and inorganic cations..” Biochemical Pharmacology 40, no. 3 (August 1990): 473–79. https://doi.org/10.1016/0006-2952(90)90545-v.
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  - Sriram, R., and F. Ali-Osman. “S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells..” Analytical Biochemistry 187, no. 2 (June 1990): 345–48. https://doi.org/10.1016/0003-2697(90)90467-n.
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  - Ali-Osman, F., K. Srivenugopal, M. S. Berger, and D. E. Stein. “DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance..” Anticancer Research 10, no. 3 (May 1990): 677–82.
  - Canady, K. S., F. Ali-Osman, and E. W. Rubel. “Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells..” Glia 3, no. 5 (January 1990): 368–74. https://doi.org/10.1002/glia.440030508.
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  - Sriram, R., and F. Ali-Osman. “S₁-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells.” Analytical Biochemistry 187, no. 2 (1990): 345–48. https://doi.org/10.1016/0003-2697(90)90467-N.
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  - Ali-Osman, F., J. Caughlan, and G. S. Gray. “Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione..” Cancer Research 49, no. 21 (November 1989): 5954–58.
  - Ali-Osman, F. “Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione..” Cancer Research 49, no. 19 (October 1989): 5258–61.
  - Ali-Osman, F., and P. A. Beltz. “Optimization and characterization of the capillary human tumor clonogenic cell assay..” Cancer Research 48, no. 3 (February 1988): 715–24.
  - Ali-Osman, F., J. Giblin, D. Dougherty, and M. L. Rosenblum. “Application of in vivo and in vitro pharmacokinetics for physiologically relevant drug exposure in a human tumor clonogenic cell assay..” Cancer Research 47, no. 14 (July 1987): 3718–24.
  - Moezzi, J., F. Ali-Osman, and M. J. Murphy. “Rapid method for permanent slide preparation of colonies in soft agar cultures..” International Journal of Cell Cloning 4, no. 5 (September 1986): 368–74. https://doi.org/10.1002/stem.5530040508.
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  - Moezzi, J., F. Ali-Osman, G. L. Nicholson, J. S. Ungerleider, and M. J. Murphy. “Relationship between histopathology and in vitro clonogenicity in breast cancer..” Breast Cancer Research and Treatment 8, no. 2 (January 1986): 147–56. https://doi.org/10.1007/bf01807703.
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  - Hübner, G. E., F. Ali-Osman, M. Kastner, C. Papadimitriou, and H. R. Maurer. “Reculturing of cells from primary CFU-C colonies..” Zeitschrift Fur Naturforschung. Section C, Biosciences 40, no. 11–12 (November 1985): 891–97.
  - Ali-Osman, F., J. Giblin, M. Berger, M. J. Murphy, and M. L. Rosenblum. “Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas..” Cancer Research 45, no. 9 (September 1985): 4185–91.
  - Ali-Osman, F., M. L. Rosenblum, D. D. Giannini, and V. A. Levin. “Potential antiglioma activity of 9-hydroxy-2-N-methylellipticine as determined by pharmacological and human tumor clonogenic cell studies..” Cancer Research 45, no. 7 (July 1985): 2988–92.
  - Ali-Osman, F., J. Giblin, and M. Berger. “In vitro bone marrow cytotoxicity of nitrosoureas: Possible role for carbamoylation.” Proceedings of the American Association for Cancer Research VOL. 26 (January 1, 1985).
  - Berger, M. S., R. E. Talcott, M. L. Rosenblum, M. Silva, F. AliOsman, and M. T. Smith. “Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations..” Journal of Toxicology and Environmental Health 16, no. 5 (January 1985): 713–19. https://doi.org/10.1080/15287398509530781.
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  - Dittmar, W., G. Klitschka, R. Braun, F. Ali-Osman, C. Meckert, and H. R. Maurer. “In vitro and in vivo investigations for the development of cytostatic methylhydrazones..” Journal of Cancer Research and Clinical Oncology 110, no. 2 (January 1985): 110–14. https://doi.org/10.1007/bf00402721.
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  - Maurer, H. R., C. Meckert, F. Ali-Osman, and J. Musil. “Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU)..” Arzneimittel Forschung 34, no. 9 (January 1984): 939–43.
  - Osman, F. A., J. Bier, H. Bier, T. Siegel, H. R. Maurer, and S. Ohanian. “Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity..” International Journal of Cell Cloning 1, no. 2 (June 1983): 118–27. https://doi.org/10.1002/stem.5530010206.
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  - Ali Osman, F., H. R. Maurer, and J. Bier. “In vitro cytostatic drug sensitivity testing in the human tumor stem cell assay: A modified method for the determination of the sensitivity index.” Tumor Diagnostik Und Therapie 4, no. 1 (January 1, 1983): 1–6.
  - Ali-Osman, F., and H. R. Maurer. “Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity..” Journal of Cancer Research and Clinical Oncology 106, no. 1 (January 1983): 17–20. https://doi.org/10.1007/bf00399892.
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  - Neumeier, R., F. Ali-Osman, and H. R. Maurer. “Two different types of granulocyte colony-stimulating factor produced by bovine lung tissue..” Blut 44, no. 1 (January 1982): 21–27. https://doi.org/10.1007/bf00320683.
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  - Maurer, H. R., and F. Ali-Osman. “Tumor stem cell cloning in agar-containing capillaries..” Die Naturwissenschaften 68, no. 7 (July 1981): 381–83. https://doi.org/10.1007/bf01058036.
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  - Ali-Osman, F., and H. R. Maurer. “Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays..” Journal of Cancer Research and Clinical Oncology 98, no. 3 (January 1980): 221–31. https://doi.org/10.1007/bf00410786.
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  - Osman, F. A., and H. R. Maurer. “Comparative cell kinetic studies of the L1210 leukemic line differential, effects of cytostatics and a lymphocyte chalone extract on this cell line and on peripheral human lymphocytes after PHA-stimulation.” Cell and Tissue Kinetics 13, no. 2 (January 1, 1980).
- Book Sections
  - Buolamwini, J. K., and F. Ali-Osman. “Dynamic docking study of the binding of 1-chloro-2,4-dinitrobenzene in the putative electrophile binding site of naturally occurring human glutathione s-transferase pi allelo-polymorphic proteins.” In Biologically Active Natural Products: Pharmaceuticals, 188–98, 1999. https://doi.org/10.1201/9781420048650.
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- Other Articles
  - Augustine, C. K., J. S. Yoo, A. Potti, Y. Yoshimoto, P. A. Zipfel, H. S. Friedman, J. R. Nevins, F. Ali-Osman, and D. S. Tyler. “Correction: Article on genomic and molecular profiling to predict response to temozolomide (Clinical Cancer Research (2009) 15, (502-510)).” Clinical Cancer Research, May 1, 2009. https://doi.org/10.1158/1078-0432.CCR-15-9-COR.
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- Conference Papers
  - Amirian, E Susan, Georgina Armstrong, Renke Zhou, Margaret Wrensch, Sara Olson, Michael Scheurer, Dora Il’yasova, et al. “DEMOGRAPHICS AND LIFESTYLE FACTORS IN GLIOMA RISK: A REPORT FROM THE GLIOMA INTERNATIONAL CASE-CONTROL STUDY.” In Neuro Oncology, 18:57–58. OXFORD UNIV PRESS INC, 2016.
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  - Advani, Anjali S., William Tse, Xuefei Jia, Paul Elson, Brenda Cooper, Francis Ali-Osman, Jino Park, et al. “Long-Term Follow-up Results: A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed c-Kit Positive Acute Myeloid Leukemia (AML).” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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  - Lidsky, M. E., R. S. Turley, P. Speicher, C. K. Augustine, F. Ali-Osman, and D. S. Tyler. “Termination of BRAF Targeted Therapy Augments Tumor Growth in the Setting of Vemurafenib Resistance.” In Annals of Surgical Oncology, 20:S90–S90. SPRINGER, 2013.
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  - Flores, Rafael Diaz, Fernando Rivera, John Zink, Colleen Stoeppel, Francis Ali-Osman, Ming-Mei Liu, Joseph Minei, and Christian Minshall. “ADRENOMEDULLIN (ADM) LEVELS IN BONCHOALVEOLAR LAVAGE (BAL) PREDICT VENTILATOR ASSOCIATED PNEUMONIA (VAP) IN PATIENTS WITH A HIGH CLINICAL PULMONARY INFECTION SCORE (CPIS).” In Critical Care Medicine, 40:U114–U114, 2012.
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  - Advani, Anjali, Brenda Cooper, Olumuyiwa Sowunmi, Paul Elson, Francis Ali-Osman, Jino Park, Arati Rao, et al. “A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed C-Kit Positive Acute Myeloid Leukemia (AML).” In Blood, Vol. 120. AMER SOC HEMATOLOGY, 2012.
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  - Antoun, Gamil R., R. McLendon, H. Friedman, A. Friedman, D. Bigner, and F. Ali-Osman. “The mutational status of the p53 tumor suppressor gene is a determinant of GSTP1 expression and mediates GSTP1-dependent drug resistance in human glioblastoma.” In Cancer Research, Vol. 72, 2012. https://doi.org/10.1158/1538-7445.AM2012-1177.
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  - Cao, Xinyu, Hu Zhu, Darell Bigner, Francis Ali-Osman, and Hui-Wen Lo. “GAIN-OF-FUNCTION tGLI1 TRANSCRIPTION FACTOR AUGMENTS ANCHORAGE-INDEPENDENT GROWTH OF MEDULLOBLASTOMA CELLS AND CONFERS THEIR RESISTANCE TO SMO INHIBITORS.” In Neuro Oncology, 13:I9–I9. OXFORD UNIV PRESS INC, 2011.
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  - Cao, Xinyu, Hu Zhu, Darell Bigner, Francis Ali-Osman, and Hui-Wen Lo. “EGFR AND EGFRvIII UNDERGO STRESS- AND EGFR KINASE INHIBITOR-INDUCED MITOCHONDRIAL TRANSLOCALIZATION IN GLIOBLASTOMA: A POTENTIAL MECHANISM OF EGFR- AND EGFRvIII-DRIVEN ANTAGONISM OF APOPTOSIS AND DRUG RESPONSE.” In Neuro Oncology, 13:I8–9. OXFORD UNIV PRESS INC, 2011.
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  - Zhu, Hu, Xinyu Cao, Steve Keir, Darell Bigner, Francis Ali-Osman, and Hui-Wen Lo. “UPREGULATION OF VEGF-A GENE EXPRESSION BY THE tGLI1 TRANSCRIPTION FACTOR CONTRIBUTES TO GLIOBLASTOMA ANGIOGENESIS.” In Neuro Oncology, 13:I15–16. OXFORD UNIV PRESS INC, 2011.
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  - Zhu, Hu, Xinyu Cao, Steve Keir, Francis Ali-Osman, and Hui-Wen Lo. “UNDERSTANDING AND TARGETING KINASE-INDEPENDENT ACTIVITY OF EGFR AND EGFRVIII TO OVERCOME GBM DRUG RESISTANCE.” In Neuro Oncology, 12:8–8. OXFORD UNIV PRESS INC, 2010.
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  - Ali-Osman, Francis, Kouros Owzar, Bartley Adams, Eric Lipp, James Herdon, Dora Illyasova, Faith Davis, et al. “GENETIC DIVERSITY ASSOCIATED WITH SURVIVAL IN MALIGNANT GLIOMAS IDENTIFIED BY LINKAGE DISEQUILIBRIUM-BASED ANALYSIS OF HAPLOTYPE BLOCK REGIONS OF DNA REPAIR GENES.” In Neuro Oncology, 11:891–891. OXFORD UNIV PRESS INC, 2009.
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  - Okamura, Tatsunori, and Francis Ali-Osman. “DIRECT TYROSINE PHOSPHORYLATION OF GSTP1 BY EGFR INDUCES JNK ACTIVATION IN GLIOBLASTOMA CELLS.” In Neuro Oncology, 11:894–894. OXFORD UNIV PRESS INC, 2009.
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  - Lo, Hui-Wen, Lisa Stephenson, Xinyu Cao, Raphael Pollock, Mira Milas, and Francis Ali-Osman. “IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN GSTP1 GENE AS A NOVEL TRANSCRIPTIONAL TARGET OF THE P53 TUMOR SUPPRESSOR GENE.” In Neuro Oncology, 10:766–766. OXFORD UNIV PRESS INC, 2008.
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  - Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “CONSTITUTIVE STAT3 ACTIVATION FREQUENTLY COEXISTS WITH EGFR EXPRESSION IN HIGH-GRADE GLIOMAS AND TARGETING STAT3 SENSITIZES THEM TO ANTI-EGFR AND ALKYLATING AGENTS.” In Neuro Oncology, 10:766–766. OXFORD UNIV PRESS INC, 2008.
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  - Okamura, Tatsunori, Simendra Singh, Darell Bigner, and Francis Ali-Osman. “LIGAND-DEPENDENT ACTIVATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INDUCES EARLY DRUG RESISTANCE IN BRAIN TUMOR CELLS VIA ACTIVATION OF ITS DOWNSTREAM TARGET GLUTATHIONE S-TRANSFERASE P1.” In Neuro Oncology, 10:782–782. OXFORD UNIV PRESS INC, 2008.
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  - Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Stat3 constitutive activation is associated with glioma tumor grade: Pathway profiling and therapy.” In Neuro Oncology, 9:550–550. DUKE UNIV PRESS, 2007.
  - Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Targeting constitutively activated stat3 sensitizes medulloblastomas to chemotherapeutic agents.” In Neuro Oncology, 9:560–560. DUKE UNIV PRESS, 2007.
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  - Wang, Jiangbo, Renshui Liu, Michael Bond, Minyong Chen, Simandra Singh, Francis Ali-Osman, Robert J. Lefkowitz, et al. “Targeting hedgehog signaling in medulloblastoma.” In Neuro Oncology, 9:560–61. DUKE UNIV PRESS, 2007.
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  - Ali-Osman, Francis. “Polymorphism of the promoter of the epidermal growth factor (EGF) gene in patients, its distribution and correlation with survival in glioma patients.” In Neuro Oncology, 8:420–420. DUKE UNIV PRESS, 2006.
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  - Okamura, Tatsunori, Timothy Haystead, Darell D. Bigner, and Francis Ali-Osman. “Glutathione S-transferase P1 (GSTP1) is a novel downstream target of Akt in human gliomas.” In Neuro Oncology, 8:400–400. DUKE UNIV PRESS, 2006.
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  - Yoo, J., C. K. Augustine, Y. Yoshimoto, R. P. Petersen, S. K. Pruitt, F. Ali-Osman, and D. S. Tyler. “Role of BAY 43-9006 in combination with temozolomide and melphalan in metastatic melanoma.” In Annals of Surgical Oncology, 13:12–12. SPRINGER, 2006.
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  - Wanko, S. O., J. P. Gockerman, J. O. Moore, C. de Castro, L. Diehl, R. Pronitz, C. Gasparetto, et al. “Multimodal dose dense therapy for mantle cell lymphoma..” In Blood, 106:463B-463B. AMER SOC HEMATOLOGY, 2005.
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  - Yoo, Jin S., Yasunori Yoshimoto, Rebecca P. Petersen, Scott K. Pruitt, Francis Ali-Osman, and Douglas S. Tyler. “Glutathione S-transferase as a marker of metastatic potential in malignant melanoma.” In Journal of the American College of Surgeons, 201:S84–S84. Elsevier BV, 2005. https://doi.org/10.1016/j.jamcollsurg.2005.06.197.
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  - Ali-Osman, F., H. Lo, G. Antoun, A. Friedman, H. Friedman, and D. Bigner. “A novel mechanism of PKA- and PKC-dependent drug resistance in human gliomas involving phosphorylation and metabolic activation of glutathione S-transferase P1 (GSTP1).” In Neuro Oncology, 7:377–377. DUKE UNIV PRESS, 2005.
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  - Ali-Osman, F., J. E. Herndon, L. Stephenson, F. Davis, B. McCarthy, D. Reardon, A. Friedman, R. McClendon, H. Friedman, and D. D. Bigner. “Prevalence and prognostic significance of polymorphisms at the glutathione S-transferase M1, M3, P1, and T1 gene loci in human astrocytomas.” In Neuro Oncology, 7:304–304. DUKE UNIV PRESS, 2005.
  - Ishimoto, T., and F. Ali-Osman. “Pharmacogenetics of the human glutathione S-transferase P1 gene and tumor response to chemotherapy.” In European Journal of Cancer, 38:S157–58, 2002.
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  - Scholl, R., M. Blandford, L. Ballard, J. B. Magee, S. Williams, M. Robertson, F. Ali-Osman, R. Lemons, and C. Keller. “A high throughput fluorescent assay for the detection of glutathione S-transferase polymorphic alleles.” In American Journal of Human Genetics, 71:463–463, 2002.
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