Francis Ali-Osman | Scholars@Duke

Francis Ali-Osman
Margaret Harris and David Silverman Professor of Neuro-Oncology Research

Current Appointments & Affiliations

Margaret Harris and David Silverman Professor of Neuro-Oncology Research, Neurosurgery, Neuro-Oncology, Neurosurgery 2004
Professor Emeritus in Neurosurgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003

Contact Information

199 Medical Science Research B, Durham, NC 27710
Box 3156 Med Ctr, Durham, NC 27710
francis.aliosman@duke.edu (919) 681-5769

Background
Education, Training, & Certifications
- D.Sc., Free University of Berlin (Germany) 1982
Duke Appointment History
- Professor in Pathology, Pathology, Clinical Science Departments 2004 - 2018
- Professor in Neurosurgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2017 - 2018
- Professor of Surgery, Surgery, Surgical Sciences, Surgery 2004 - 2017
- Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2003
Expertise
Global Scholarship
- Research
  - Ghana (Country)
Research
Selected Grants
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- P53-dependent GSTP1 Gene Regulation and Glioma Drug Resistance awarded by National Institutes of Health 2010 - 2015
- Protein Kinase C and GSTP1 interactions in glioma drug resistance awarded by National Institutes of Health 2008 - 2014
- NCI Howard Temin Award (K01) Transition awarded by National Institutes of Health 2006 - 2012
- Novel Targeted Therapeutics for CNS Malignancies awarded by National Institutes of Health 2006 - 2011
- Radionuclide-based Molecular Imaging of the DNA Repair Protein AGT awarded by National Institutes of Health 2009 - 2011
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- DNA Methylation and GSTP1 Gene Regulation in Gliomas awarded by National Institutes of Health 2002 - 2008
- Planning a Duke Academic Public Private Partnership Program (AP4) Center awarded by National Cancer Institute 2004 - 2006
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Amirian, ES, Ostrom, QT, Armstrong, GN, Lai, RK, Gu, X, Jacobs, DI, Jalali, A, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, JM, Ali-Osman, F, Sadetzki, S, Jenkins, RB, Lachance, DH, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Johansen, C, Houlston, RS, Scheurer, ME, Shete, S, Amos, CI, Melin, B, and Bondy, ML. "Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 28, no. 3 (March 2019): 555-562. Full Text
  - Erdal, S, McCarthy, BJ, Gurule, N, Berwick, M, Gonzales, E, Byrd, J, Flores, K, Shimek, J, Il'yasova, D, Ali-Osman, F, Bigner, DD, Davis, FG, Leyba, AN, and White, KAM. "Application of mutagen sensitivity assay in a glioma case-control study." Toxicology Reports 5 (January 9, 2018): 183-188. Full Text
  - Madala, HR, Punganuru, SR, Ali-Osman, F, Zhang, R, and Srivenugopal, KS. "Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts." Oncotarget 9, no. 3 (January 2018): 3459-3482. Full Text
  - Melin, BS, Barnholtz-Sloan, JS, Wrensch, MR, Johansen, C, Il'yasova, D, Kinnersley, B, Ostrom, QT, Labreche, K, Chen, Y, Armstrong, G, Liu, Y, Eckel-Passow, JE, Decker, PA, Labussière, M, Idbaih, A, Hoang-Xuan, K, Di Stefano, A-L, Mokhtari, K, Delattre, J-Y, Broderick, P, Galan, P, Gousias, K, Schramm, J, Schoemaker, MJ, Fleming, SJ, Herms, S, Heilmann, S, Nöthen, MM, Wichmann, H-E, Schreiber, S, Swerdlow, A, Lathrop, M, Simon, M, Sanson, M, Andersson, U, Rajaraman, P, Chanock, S, Linet, M, Wang, Z, Yeager, M, GliomaScan Consortium, , Wiencke, JK, Hansen, H, McCoy, L, Rice, T, Kosel, ML, Sicotte, H, Amos, CI, Bernstein, JL, Davis, F, Lachance, D, Lau, C, Merrell, RT, Shildkraut, J, Ali-Osman, F, Sadetzki, S, Scheurer, M, Shete, S, Lai, RK, Claus, EB, Olson, SH, Jenkins, RB, Houlston, RS, and Bondy, ML. "Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors." Nature Genetics 49, no. 5 (May 2017): 789-794. Full Text
  - Paranjpe, A, Bailey, NI, Konduri, S, Bobustuc, GC, Ali-Osman, F, Yusuf, MA, Punganuru, SR, Madala, HR, Basak, D, Mostofa, A, and Srivenugopal, KS. "New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy." Journal of Biomedical Research 30, no. 5 (September 2016): 393-410. Full Text
  - Amirian, ES, Scheurer, ME, Zhou, R, Wrensch, MR, Armstrong, GN, Lachance, D, Olson, SH, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Jenkins, RB, Bernstein, JL, Merrell, RT, Davis, FG, Lai, R, Shete, S, Amos, CI, Melin, BS, and Bondy, ML. "History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC)." Cancer Medicine 5, no. 6 (June 2016): 1352-1358. Full Text
  - Amirian, ES, Zhou, R, Wrensch, MR, Olson, SH, Scheurer, ME, Il'yasova, D, Lachance, D, Armstrong, GN, McCoy, LS, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Bernstein, JL, Merrell, RT, Davis, FG, Lai, R, Shete, S, Amos, CI, Melin, BS, and Bondy, ML. "Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 25, no. 2 (February 2016): 282-290. Full Text
  - Amirian, ES, Armstrong, GN, Zhou, R, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Davis, FG, Lai, R, Shete, S, Amos, CI, Scheurer, ME, Aldape, K, Alafuzoff, I, Brännström, T, Broholm, H, Collins, P, Giannini, C, Rosenblum, M, Tihan, T, Melin, BS, and Bondy, ML. "The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium." American Journal of Epidemiology 183, no. 2 (January 2016): 85-91. Full Text
  - Okamura, T, Antoun, G, Keir, ST, Friedman, H, Bigner, DD, and Ali-Osman, F. "Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells." The Journal of Biological Chemistry 290, no. 52 (December 2015): 30866-30878. Full Text
  - Brown, KE, Chagoya, G, Kwatra, SG, Yen, T, Keir, ST, Cooter, M, Hoadley, KA, Rasheed, A, Lipp, ES, Mclendon, R, Ali-Osman, F, Bigner, DD, Sampson, JH, and Kwatra, MM. "Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development." Journal of Neurochemistry 133, no. 5 (June 2015): 730-738. Full Text
  - Jalali, A, Amirian, ES, Bainbridge, MN, Armstrong, GN, Liu, Y, Tsavachidis, S, Jhangiani, SN, Plon, SE, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Davis, FG, Lai, R, Shete, S, Aldape, K, Amos, CI, Muzny, DM, Gibbs, RA, Melin, BS, and Bondy, ML. "Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium." Scientific Reports 5 (February 5, 2015): 8278-null. Full Text
  - Bainbridge, MN, Armstrong, GN, Gramatges, MM, Bertuch, AA, Jhangiani, SN, Doddapaneni, H, Lewis, L, Tombrello, J, Tsavachidis, S, Liu, Y, Jalali, A, Plon, SE, Lau, CC, Parsons, DW, Claus, EB, Barnholtz-Sloan, J, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Walsh, KM, Davis, FG, Lai, R, Shete, S, Aldape, K, Amos, CI, Thompson, PA, Muzny, DM, Gibbs, RA, Melin, BS, Bondy, ML, and Gliogene Consortium, . "Germline mutations in shelterin complex genes are associated with familial glioma." Journal of the National Cancer Institute 107, no. 1 (January 2015): 384-null. Full Text
  - Brown, KE, Chagoya, G, Kwatra, SG, Yen, T, Keir, ST, Cooter, M, Hoadley, KA, Rasheed, A, Lipp, ES, McLendon, R, Ali-Osman, F, Bigner, DD, Sampson, JH, and Kwatra, MM. "Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: Implications for drug development." Journal of Neurochemistry 133, no. 5 (2015): 730-738. Full Text
  - Lidsky, M, Antoun, G, Speicher, P, Adams, B, Turley, R, Augustine, C, Tyler, D, and Ali-Osman, F. "Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells." The Journal of Biological Chemistry 289, no. 40 (October 2014): 27714-27726. Full Text
  - Paranjpe, A, Zhang, R, Ali-Osman, F, Bobustuc, GC, and Srivenugopal, KS. "Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage." Carcinogenesis 35, no. 3 (March 2014): 692-702. Full Text
  - Kinev, AV, Levering, V, Young, K, Ali-Osman, F, Truskey, GA, Dewhirst, MW, and Il'yasova, D. "Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose." Cancer Invest 31, no. 5 (June 2013): 359-364. Full Text Link to Item
  - "Correction." Cancer Science 104, no. 2 (February 2013): 274-274. Full Text
  - Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Science 104, no. 1 (January 2013): 70-77. Full Text
  - Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Science 104, no. 1 (2013): 70-77. Full Text
  - Okamura, T, and Ali-Osman, F. "Abstract 2162: EGFR-induced interaction of GSTP1 with the SH2-domain of Grb2 enhances Ras downstream activation in human glioma cells." Cancer Research 72, no. 8 Supplement (April 15, 2012): 2162-2162. Full Text
  - Turley, RS, Lidsky, ME, Tyler, DS, and Ali-Osman, F. "Abstract 2012: MAP kinase activation and suppression of anti-apoptotic Bcl-2 family members are associated with induction of apoptotic death in melanoma cells following down-regulation of glutathione S-transferase P1." Cancer Research 72, no. 8 Supplement (April 15, 2012): 2012-2012. Full Text
  - Lachance, DH, Yang, P, Johnson, DR, Decker, PA, Kollmeyer, TM, McCoy, LS, Rice, T, Xiao, Y, Ali-Osman, F, Wang, F, Stoddard, SM, Sprau, DJ, Kosel, ML, Wiencke, JK, Wiemels, JL, Patoka, JS, Davis, F, McCarthy, B, Rynearson, AL, Worra, JB, Fridley, BL, O'Neill, BP, Buckner, JC, Il'yasova, D, Jenkins, RB, and Wrensch, MR. "Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking." American Journal of Epidemiology 174, no. 5 (September 2011): 574-581. Full Text
  - Cao, X, Dewhirst, M, Ali-Osman, F, and Lo, H-W. "Abstract 2337: Defining significance of the novel tGLI1 transcription factor in cancer growth and progression." Cancer Research 71, no. 8 Supplement (April 15, 2011): 2337-2337. Full Text
  - Okamura, T, and Ali-osman, F. "Abstract 703: GSTP1 inhibition of HSP27 phosphorylation contributes to glioma drug resistance." Cancer Research 71, no. 8 Supplement (April 15, 2011): 703-703. Full Text
  - Turley, RS, Liu, J, Tyler, D, and Ali-Osman, F. "Abstract 1635: Short hairpin RNA-mediated transcriptional suppression of glutathione S-transferase P1 suppresses growth and induces apoptosis through altered MAP kinase signaling in melanoma cells." Cancer Research 71, no. 8 Supplement (April 15, 2011): 1635-1635. Full Text
  - Cao, X, Zhu, H, Ali-Osman, F, and Lo, H-W. "EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis." Molecular Cancer 10 (March 9, 2011): 26-null. Full Text
  - McCarthy, BJ, Rankin, K, Il'yasova, D, Erdal, S, Vick, N, Ali-Osman, F, Bigner, DD, and Davis, F. "Assessment of type of allergy and antihistamine use in the development of glioma." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 20, no. 2 (February 2011): 370-378. Full Text
  - Advani, AS, Shadman, M, Ali-Osman, F, Barker, A, Rybicki, L, Kalaycio, M, Sekeres, MA, de Castro, CM, Diehl, LF, Moore, JO, Beaven, A, Copelan, E, Sobecks, R, Talea, P, and Rizzieri, DA. "A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse." Clinical Lymphoma, Myeloma & Leukemia 10, no. 6 (December 2010): 473-476. Full Text
  - Jones, LW, Ali-Osman, F, Lipp, E, Marcello, JE, McCarthy, B, McCoy, L, Rice, T, Wrensch, M, and Il'yasova, D. "Association between body mass index and mortality in patients with glioblastoma mutliforme." Cancer Causes & Control : Ccc 21, no. 12 (December 2010): 2195-2201. Full Text
  - Cui, B, Johnson, SP, Bullock, N, Ali-Osman, F, Bigner, DD, and Friedman, HS. "Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells." Journal of Biomedical Research 24, no. 6 (November 2010): 424-435. Full Text
  - Singh, S, Okamura, T, and Ali-Osman, F. "Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells." Biochemical Pharmacology 80, no. 9 (November 2010): 1343-1355. Full Text
  - Toshimitsu, H, Yoshimoto, Y, Augustine, CK, Padussis, JC, Yoo, JS, Angelica Selim, M, Pruitt, SK, Friedman, HS, Ali-Osman, F, and Tyler, DS. "Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma." Annals of Surgical Oncology 17, no. 8 (August 2010): 2247-2254. Full Text
  - Zhu, H, Cao, X, Ali-Osman, F, Keir, S, and Lo, H-W. "EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity." Cancer Letters 294, no. 1 (August 2010): 101-110. Full Text
  - Augustine, CK, Toshimitsu, H, Jung, S-H, Zipfel, PA, Yoo, JS, Yoshimoto, Y, Selim, MA, Burchette, J, Beasley, GM, McMahon, N, Padussis, J, Pruitt, SK, Ali-Osman, F, and Tyler, DS. "Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy." Molecular Cancer Therapeutics 9, no. 7 (July 2010): 2090-2101. Full Text
  - Crout, CA, Koh, L-P, Gockerman, JP, Moore, JO, Decastro, C, Long, GD, Diehl, L, Gasparetto, C, Niedzwiecki, D, Edwards, J, Prosnitz, L, Horwitz, M, Chute, J, Morris, A, Davis, P, Beaven, A, Chao, NJ, Ali-Osman, F, and Rizzieri, DA. "Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy." Cancer Invest 28, no. 6 (July 2010): 654-660. Full Text Link to Item
  - Augustine, CK, Jung, S-H, Sohn, I, Yoo, JS, Yoshimoto, Y, Olson, JA, Friedman, HS, Ali-Osman, F, and Tyler, DS. "Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma." Molecular Cancer Therapeutics 9, no. 4 (April 6, 2010): 779-790. Full Text
  - Lo, H-W, Cao, X, Zhu, H, and Ali-Osman, F. "Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes." Molecular Cancer Research : Mcr 8, no. 2 (February 9, 2010): 232-245. Full Text
  - Lo, H-W, Zhu, H, Cao, X, Aldrich, A, and Ali-Osman, F. "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion." Cancer Research 69, no. 17 (September 2009): 6790-6798. Full Text
  - Cui, B, Johnson, SP, Bullock, N, Ali-Osman, F, Bigner, DD, and Friedman, HS. "Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway." Mol Pharmacol 75, no. 6 (June 2009): 1356-1363. Full Text Link to Item
  - Okamura, T, Singh, S, Buolamwini, J, Haystead, T, Friedman, H, Bigner, D, and Ali-Osman, F. "Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor." The Journal of Biological Chemistry 284, no. 25 (June 2009): 16979-16989. Full Text
  - Antoun, G, and Ali-Osman, F. "Structural and functional analysis of Nucleophosmin I (NPM1) in human malignant gliomas." Cancer Research 69 (May 1, 2009). Link to Item
  - Okamura, T, and Ali-Osman, F. "Phosphorylation of a C-terminal tyrosine of GSTP1 by EGFR dissociates GSTP1 from the GSTP1-JNK complex leading to JNK activation in glioblastoma cells." Cancer Research 69 (May 1, 2009). Link to Item
  - Singh, S, and Ali-Osman, F. "Serine-phosphorylation of the GSTP1 protein by PKC\#945; increase GSTP1-mediated cisplatin metabolism and descrease cisplatin-induced DNA interstrand cross link formation and cisplatin sensitivity in human glioma cells." Cancer Research 69 (May 1, 2009). Link to Item
  - Zhu, H, Cao, X, Aldrich, A, Ali-Osman, F, and Lo, H-W. "EGFR and EGFRvIII attenuate drug-induced apoptosis in glioblastomas via mitochondrial transport and interaction with pro-apoptotic proteins:A novel EGFR/EGFRvIII-mediated mechanism in drug resistance." Cancer Research 69 (May 1, 2009). Link to Item
  - Il'yasova, D, McCarthy, B, Marcello, J, Schildkraut, JM, Moorman, PG, Krishnamachari, B, Ali-Osman, F, Bigner, DD, and Davis, F. "Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 18, no. 4 (April 2009): 1232-1238. Full Text
  - Okamura, T, Singh, S, Buolamwini, JK, Friedman, HS, Bigner, DD, and Ali-Osman, F. "EGF RECEPTOR TYROSINE KINASE MEDIATES A NOVEL PATHWAY OF DRUG RESISTANCE IN MALIGNANT GLIOMAS VIA TYROSINE PHOSPHORYLATION AND FUNCTIONAL ACTIVATION OF GLUTATHIONE S-TRANSFERASE P1." NEURO-ONCOLOGY 11, no. 2 (April 2009): 218-218. Link to Item
  - Augustine, CK, Yoo, JS, Potti, A, Yoshimoto, Y, Zipfel, PA, Friedman, HS, Nevins, JR, Ali-Osman, F, and Tyler, DS. "Genomic and molecular profiling predicts response to temozolomide in melanoma." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 2 (January 2009): 502-510. Full Text
  - Lo, H-W, Cao, X, Zhu, H, and Ali-Osman, F. "Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 14, no. 19 (October 2008): 6042-6054. Full Text
  - Maxwell, JA, Johnson, SP, McLendon, RE, Lister, DW, Horne, KS, Rasheed, A, Quinn, JA, Ali-Osman, F, Friedman, AH, Modrich, PL, Bigner, DD, and Friedman, HS. "Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 14, no. 15 (August 2008): 4859-4868. Full Text
  - Xie, T-X, Aldape, KD, Gong, W, Kanzawa, T, Suki, D, Kondo, S, Lang, F, Ali-Osman, F, Sawaya, R, and Huang, S. "Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor." Int J Oncol 33, no. 1 (July 2008): 5-15. Link to Item
  - Augustine, CK, Jung, S, Potti, A, Sohn, I, Yoo, JS, Zipfel, P, Jr, OJ, Ali-Osman, F, Nevins, JR, and Tyler, DS. "Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma." JOURNAL OF CLINICAL ONCOLOGY 26, no. 15 (May 20, 2008). Full Text Link to Item
  - Augustine, CK, Jung, S, Potti, A, Sohn, I, Yoo, JS, Zipfel, P, Olson, J, Ali-Osman, F, Nevins, JR, and Tyler, DS. "Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma." J Clin Oncol 26, no. 15_suppl (May 20, 2008): 9077-. Link to Item
  - Lo, H-W, Stephenson, L, Cao, X, Milas, M, Pollock, R, and Ali-Osman, F. "Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene." Molecular Cancer Research : Mcr 6, no. 5 (May 2008): 843-850. Full Text
  - Lo, H-W, and Ali-Osman, F. "Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance." Current Opinion in Pharmacology 7, no. 4 (August 6, 2007): 367-374. (Review) Full Text
  - Yoshimoto, Y, Augustine, CK, Yoo, JS, Zipfel, PA, Selim, MA, Pruitt, SK, Friedman, HS, Ali-Osman, F, and Tyler, DS. "Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents." Molecular Cancer Therapeutics 6, no. 5 (May 4, 2007): 1492-1500. Full Text
  - Tew, KD, and Ali-Osman, F. "Redox pathways in cancer drug discovery." Current Opinion in Pharmacology 7, no. 4 (2007): 353-354. Full Text
  - Maxwell, JA, Johnson, SP, Quinn, JA, McLendon, RE, Ali-Osman, F, Friedman, AH, Herndon, JE, Bierau, K, Bigley, J, Bigner, DD, and Friedman, HS. "Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma." Mol Cancer Ther 5, no. 10 (October 2006): 2531-2539. Full Text Link to Item
  - Cheng, CL, Johnson, SP, Keir, ST, Quinn, JA, Ali-Osman, F, Szabo, C, Li, H, Salzman, AL, Dolan, ME, Modrich, P, Bigner, DD, and Friedman, HS. "Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft." Molecular Cancer Therapeutics 4, no. 9 (September 2005): 1364-1368. Full Text
  - "Correction: Article on the Enforced Expression of Wild-Type p53 and the Transcription of the O6-Methylguanine-DNA Methyltransferase Gene." Clinical Cancer Research 11, no. 6 (March 15, 2005): 2449-2449. Full Text
  - Shou, J, Srivenugopal, KS, Mullapudi, SRS, Lang, FF, Rao, JS, and Ali-Osman, F. "Article on the enforced expression of wild-type p53 and the transcription of the O-6 -methylguanine-DNA methyltransferase gene (vol 7, pg 1398, 2001)." Clinical Cancer Research 11, no. 6 (March 15, 2005): 2449-2449. Link to Item
  - Lo, H-W, Antoun, GR, and Ali-Osman, F. "The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells." Cancer Res 64, no. 24 (December 15, 2004): 9131-9138. Full Text Link to Item
  - Okcu, MF, Selvan, M, Wang, L-E, Stout, L, Erana, R, Airewele, G, Adatto, P, Hess, K, Ali-Osman, F, Groves, M, Yung, AWK, Levin, VA, Wei, Q, and Bondy, M. "Glutathione S-transferase polymorphisms and survival in primary malignant glioma." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 10, no. 8 (April 2004): 2618-2625. Full Text
  - Xie, T-X, Wei, D, Liu, M, Gao, AC, Ali-Osman, F, Sawaya, R, and Huang, S. "Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis." Oncogene 23, no. 20 (April 2004): 3550-3560. Full Text
  - Barnette, P, Scholl, R, Blandford, M, Ballard, L, Tsodikov, A, Magee, J, Williams, S, Robertson, M, Ali-Osman, F, Lemons, R, and Keller, C. "High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 13, no. 2 (February 2004): 304-313. Full Text
  - Konduri, SD, Srivenugopal, KS, Yanamandra, N, Dinh, DH, Olivero, WC, Gujrati, M, Foster, DC, Kisiel, W, Ali-Osman, F, Kondraganti, S, Lakka, SS, and Rao, JS. "Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells." Oncogene 22, no. 29 (July 2003): 4509-4516. Full Text
  - Wang, Y, Spitz, MR, Schabath, MB, Ali-Osman, F, Mata, H, and Wu, X. "Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study." Lung Cancer 40, no. 1 (April 2003): 25-32. Link to Item
  - Zheng, T, Holford, TR, Zahm, SH, Owens, PH, Boyle, P, Zhang, Y, Zhang, B, Wise, JP, Stephenson, LP, and Ali-Osman, F. "Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk." Br J Cancer 88, no. 1 (January 13, 2003): 58-62. Full Text Link to Item
  - Konduri, SD, Srivenugopal, KS, Yanamandra, N, Dinh, DH, Olivero, WC, Gujrati, M, Foster, DC, Kisiel, W, Ali-Osman, F, Kondraganti, S, Lakka, SS, and Rao, JS. "Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), in human glioma cells." Oncogene 22, no. 29 (2003): 4509-4516. Full Text
  - Ishimoto, TM, and Ali-Osman, F. "Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli." Pharmacogenetics 12, no. 7 (October 2002): 543-553. Full Text
  - Zheng, T, Holford, TR, Zahm, SH, Owens, PH, Boyle, P, Zhang, Y, Wise, JP, Stephenson, LP, and Ali-Osman, F. "Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States)." Cancer Causes & Control : Ccc 13, no. 7 (September 2002): 637-645. Full Text
  - Srivenugopal, KS, and Ali-Osman, F. "The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein." Oncogene 21, no. 38 (August 29, 2002): 5940-5945. Full Text Link to Item
  - Srivenugopal, KS, Mullapudi, SRS, and Ali-Osman, F. "Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay." Cancer Lett 181, no. 1 (July 8, 2002): 87-93. Link to Item
  - Bacolod, MD, Johnson, SP, Ali-Osman, F, Modrich, P, Bullock, NS, Colvin, OM, Bigner, DD, and Friedman, HS. "Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma." Molecular Cancer Therapeutics 1, no. 9 (July 2002): 727-736.
  - Madden, RM, Chan, KW, Stephenson, LP, and Ali-Osman, F. "Analysis and significance of the genetic polymorphism of the glutathione S-transferase P1 gene locus in pediatric tumors." Pediatric Research 51, no. 4 (April 2002): 233A-233A. Link to Item
  - Shou, J, Ali-Osman, F, Multani, AS, Pathak, S, Fedi, P, and Srivenugopal, KS. "Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA." Oncogene 21, no. 6 (January 31, 2002): 878-889. Full Text Link to Item
  - Konduri, SD, Osman, FA, Rao, CN, Srinivas, H, Yanamandra, N, Tasiou, A, Dinh, DH, Olivero, WC, Gujrati, M, Foster, DC, Kisiel, W, Kouraklis, G, and Rao, JS. "Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas." Oncogene 21, no. 6 (2002): 921-928. Full Text
  - Lo, H-W, and Ali-Osman, F. "Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation." J Cell Biochem 87, no. 1 (2002): 103-116. Full Text Link to Item
  - Mohanam, S, Jasti, SL, Kondraganti, SR, Chandrasekar, N, Lakka, SS, Kin, Y, Fuller, GN, Yung, AW, Kyritsis, AP, Dinh, DH, Olivero, WC, Gujrati, M, Ali-Osman, F, and Rao, JS. "Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells." Oncogene 20, no. 28 (June 21, 2001): 3665-3673. Full Text Link to Item
  - Srivenugopal, KS, Shou, J, Mullapudi, SR, Lang, FF, Rao, JS, and Ali-Osman, F. "Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents." Clin Cancer Res 7, no. 5 (May 2001): 1398-1409. Link to Item
  - Lakka, SS, Rajagopal, R, Rajan, MK, Mohan, PM, Adachi, Y, Dinh, DH, Olivero, WC, Gujrati, M, Ali-Osman, F, Roth, JA, Yung, WK, Kyritsis, AP, and Rao, JS. "Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 7, no. 4 (April 2001): 1087-1093.
  - Ali-Osman, F, Srivenugopal, K, and Sawaya, R. "The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents." N Engl J Med 344, no. 9 (March 1, 2001): 687-. (Letter) Link to Item
  - Maugard, CM, Charrier, J, Pitard, A, Campion, L, Akande, O, Pleasants, L, and Ali-Osman, F. "Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier." International Journal of Cancer 91, no. 3 (February 2001): 334-339. Full Text
  - Buckner, JC, Moynihan, TJ, Quinn, DI, Schlegel, U, Ali-Osman, F, Srivenugopal, K, Sawaya, R, Esteller, M, Herman, JG, and Weinstein, JN. "The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents [1] (multiple letters)." New England Journal of Medicine 344, no. 9 (2001): 686-688. Full Text
  - Lo, H-W, and Ali-Osman, F. "The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site." Chemico-Biological Interactions 133, no. 1-3 (2001): 320-321.
  - Kondraganti, S, Mohanam, S, Chintala, SK, Kin, Y, Jasti, SL, Nirmala, C, Lakka, SS, Adachi, Y, Kyritsis, AP, Ali-Osman, F, Sawaya, R, Fuller, GN, and Rao, JS. "Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion." Cancer Research 60, no. 24 (December 2000): 6851-6855.
  - Nirmala, C, Jasti, SL, Sawaya, R, Kyritsis, AP, Konduri, SD, Ali-Osman, F, Rao, JS, and Mohanam, S. "Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions." International Journal of Cancer 88, no. 5 (December 2000): 766-771. Full Text
  - Mullapudi, SR, Ali-Osman, F, Shou, J, and Srivenugopal, KS. "DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells." Biochem J 351 Pt 2 (October 15, 2000): 393-402. Link to Item
  - Ramachandran, S, Hoban, PR, Ichii-Jones, F, Pleasants, L, Ali-Osman, F, Lear, JT, Smith, AG, Bowers, B, Jones, PW, Fryer, AA, and Strange, RC. "Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours." Pharmacogenetics 10, no. 6 (August 2000): 545-556. Full Text
  - Antoun, G, Baylin, SB, and Ali-Osman, F. "DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA." J Cell Biochem 77, no. 3 (April 2000): 372-381. Link to Item
  - Chandrasekar, N, Jasti, S, Alfred-Yung, WK, Ali-Osman, F, Dinh, DH, Olivero, WC, Gujrati, M, Kyritsis, AP, Nicolson, GL, Rao, JS, and Mohanam, S. "Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions." Clin Exp Metastasis 18, no. 4 (2000): 337-342. Link to Item
  - Lakka, SS, Jasti, SL, Kyritsis, AP, Yung, WK, Ali-Osman, F, Nicolson, GL, and Rao, JS. "Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades." Clin Exp Metastasis 18, no. 3 (2000): 245-252. Link to Item
  - Srivenugopal, KS, Mullapudi, SR, Shou, J, Hazra, TK, and Ali-Osman, F. "Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells." Cancer Research 60, no. 2 (January 2000): 282-287.
  - Lo, HW, and Ali-Osman, F. "Differential transactivation of the hGSTP1 promoter by individual direct/everted repeat retinoic acid response elements in intron 5 of the hGSTP1 gene." Clinical Chemistry and Enzymology Communications 8, no. 4-6 (December 1, 1999): 293-302.
  - Ali-Osman, F, and Buolanwini, J. "Molecular modeling based design of novel anticancer therapeutics that target the active sites of polymorphic GSTP1 proteins." Clinical Cancer Research 5 (November 1999): 3841S-3841S. Link to Item
  - Multani, AS, Ozen, M, Sen, S, Mandal, AK, Price, JE, Fan, D, Radinsky, R, Ali-Osman, F, Von Eschenbach, AC, Fidler, IJ, and Pathak, S. "Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin." Int J Oncol 15, no. 3 (September 1999): 423-429. Link to Item
  - Chan, JY, and Ali-Osman, F. "In vitro repair synthesis of BCNU-induced DNA damage." Cancer Biochem Biophys 16, no. 3 (October 1998): 273-286. Link to Item
  - Ali-Osman, F, Tew, KD, and Strange, RC. "Special issue: Glutathione and glutathione-linked enzymes in human cancer and other diseases - Preface." Chemico Biological Interactions 112 (April 24, 1998): XIII-XIV. Link to Item
  - Keller, C, and Ali-Osman, F. "Translational inhibition of messenger RNA of the human pi class glutathione S-transferase by antisense oligodeoxyribonucleotides." Chem Biol Interact 111-112 (April 24, 1998): 307-323. Link to Item
  - Lo, HW, and Ali-Osman, F. "Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line." Chem Biol Interact 111-112 (April 24, 1998): 91-102. Link to Item
  - Anderson, CM, Buzaid, AC, Sussman, J, Lee, JJ, Ali-Osman, F, Braunschweiger, PG, Plager, C, Bedikian, A, Papadopoulos, N, Eton, O, Legha, SS, and Grimm, EA. "Nitric oxide and neopterin levels and clinical response in stage III melanoma patients receiving concurrent biochemotherapy." Melanoma Res 8, no. 2 (April 1998): 149-155. Link to Item
  - Buzaid, AC, Ali-Osman, F, Akande, N, Grimm, EA, Lee, JJ, Bedikian, A, Eton, O, Papadopoulos, N, Plager, C, Legha, SS, and Benjamin, RS. "DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma." Melanoma Research 8, no. 2 (April 1998): 145-148.
  - Ali-Osman, F. "Antisense oligonucleotide downregulation of human glutathione S-transferase-PI gene expression for enhanced efficacy of cancer chemotherapy." International Journal of Pediatric Hematology/Oncology 5, no. 1 (January 1, 1998): 48-49.
  - Lo, HW, and Ali-Osman, F. "Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements." J Biol Chem 272, no. 52 (December 26, 1997): 32743-32749. Link to Item
  - Ali-Osman, F, Brunner, JM, Kutluk, TM, and Hess, K. "Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas." Clin Cancer Res 3, no. 12 Pt 1 (December 1997): 2253-2261. Link to Item
  - Ali-Osman, F, Brunner, JM, Kutluk, TM, and Hess, K. "Prognostic significance of glutathione S-transferase π expression and subcellular localization in human gliomas." Clinical Cancer Research 3, no. 12 I (December 1, 1997): 2253-2261.
  - Ali-Osman, F, Brunner, JM, Kutluk, TM, and Hess, K. "Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas." Clinical Cancer Research 3, no. 12 (December 1997): 2253-2261. Link to Item
  - Srivenugopal, KS, and Ali-Osman, F. "Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues." Cancer Lett 117, no. 1 (July 15, 1997): 105-111. Link to Item
  - Chintala, SK, Ali-Osman, F, Mohanam, S, Rayford, A, Go, Y, Gokaslan, ZL, Gagercas, E, Venkaiah, B, Sawaya, R, Nicolson, GL, and Rao, JS. "Effect of cisplatin and BCNU on MMP-2 levels in human glioblastoma cell lines in vitro." Clin Exp Metastasis 15, no. 4 (July 1997): 361-367. Link to Item
  - Friedman, HS, Johnson, SP, Dong, Q, Schold, SC, Rasheed, BK, Bigner, SH, Ali-Osman, F, Dolan, E, Colvin, OM, Houghton, P, Germain, G, Drummond, JT, Keir, S, Marcelli, S, Bigner, DD, and Modrich, P. "Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft." Cancer Research 57, no. 14 (July 1997): 2933-2936.
  - Go, Y, Chintala, SK, Rayford, A, Gagercas, E, Ali-Osman, F, Venkaiah, B, Sawaya, R, Gokaslan, Z, Nicolson, GL, and Rao, JS. "Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro." Clin Exp Metastasis 15, no. 4 (July 1997): 447-452. Link to Item
  - Ali-Osman, F, Akande, O, Antoun, G, Mao, JX, and Buolamwini, J. "Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins." The Journal of Biological Chemistry 272, no. 15 (April 1997): 10004-10012. Full Text
  - Brandt, TY, and Ali-Osman, F. "Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells." Toxicol Appl Pharmacol 143, no. 1 (March 1997): 22-29. Full Text Link to Item
  - Hare, CB, Elion, GB, Colvin, OM, Ali-Osman, F, Griffith, OW, Petros, WP, Keir, S, Marcelli, SL, Bigner, DD, and Friedman, HS. "Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft." Cancer Chemotherapy and Pharmacology 40, no. 5 (January 1997): 409-414. Full Text
  - OSMAN, FA. "Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins." J. Biol. Chem. 272 (1997): 10004-10012.
  - Srivenugopal, KS, and Ali-Osman, F. "Coordinate up-regulation of cyclin-dependent kinase 4 and its inhibitor p16(INK4) in human glioma cells following chloroethylnitrosourea-induced DNA damage." International Journal of Oncology 11, no. 6 (January 1, 1997): 1251-1256.
  - Ali-Osman, F, Antoun, G, Wang, H, Rajagopal, S, and Gagucas, E. "Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells." Mol Pharmacol 49, no. 6 (June 1996): 1012-1020. Link to Item
  - Srivenugopal, KS, and Ali-Osman, F. "Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells." Oncogene 12, no. 9 (May 2, 1996): 2029-2034. Link to Item
  - Ali-Osman, F. "Culture of human normal brain and malignant brain tumors for cellular, molecular, and pharmacological studies." Methods Mol Med 2 (1996): 63-80. Full Text Link to Item
  - Dong, Q, Bullock, N, Ali-Osman, F, Colvin, OM, Bigner, DD, and Friedman, HS. "Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines." Cancer Chemotherapy and Pharmacology 37, no. 3 (January 1996): 242-246. Full Text
  - Moynihan, K, Elion, GB, Ali-Osman, F, Marcelli, S, Keir, S, Bigner, DD, and Friedman, HS. "Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta." Cancer Chemotherapy and Pharmacology 38, no. 4 (January 1996): 349-354. Full Text
  - Srivenugopal, KS, Yuan, XH, Friedman, HS, and Ali-Osman, F. "Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea." Biochemistry 35, no. 4 (January 1996): 1328-1334. Full Text
  - Wei, Q, Xu, X, Cheng, L, Legerski, RJ, and Ali-Osman, F. "Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR." Cancer Research 55, no. 21 (November 1995): 5025-5029.
  - Spence, AM, Rasey, JS, Dwyer-Hansen, L, Grunbaum, Z, Livesey, J, Chin, L, Nelson, N, Stein, D, Krohn, KA, and Ali-Osman, F. "Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates." Radiother Oncol 35, no. 3 (June 1995): 216-226. Link to Item
  - Li, L, Yoo, H, Becker, FF, Ali-Osman, F, and Chan, JY. "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid." Biochem Biophys Res Commun 206, no. 2 (January 17, 1995): 764-774. Link to Item
  - Aggarwal, BB, Pocsik, E, Totpal, K, and Ali-Osman, F. "Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene." FEBS Lett 357, no. 1 (January 2, 1995): 1-6. Link to Item
  - Ali-Osman, F, Rairkar, A, and Young, P. "Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells." Cancer Biochemistry Biophysics 14, no. 4 (January 1995): 231-241.
  - Aggarwal, BB, Pocsik, E, Ali-Osman, F, and Totpal, K. "Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor." FEBS Lett 354, no. 1 (October 31, 1994): 12-16. Link to Item
  - Buzaid, AC, Grimm, EA, Ali-Osman, F, Ring, S, Eton, O, Papadopoulos, NE, Bedikian, A, Plager, C, Legha, SS, and Benjamin, R. "Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results." Melanoma Research 4, no. 5 (October 1994): 327-330.
  - Yoshida, M, Khokhar, AR, Kido, Y, Ali-Osman, F, and Siddik, ZH. "Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin." Biochem Pharmacol 48, no. 4 (August 17, 1994): 793-799. Link to Item
  - Friedman, HS, Dolan, ME, Kaufmann, SH, Colvin, OM, Griffith, OW, Moschel, RC, Schold, SC, Bigner, DD, and Ali-Osman, F. "Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan." Cancer Research 54, no. 13 (July 1994): 3487-3493.
  - Aggarwal, BB, Totpal, K, Ali-Osman, F, Budde, RJ, and Pocsik, E. "pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor." Febs Letters 345, no. 2-3 (May 1994): 219-224. Full Text
  - Pocsik, E, Mihalik, R, Ali-Osman, F, and Aggarwal, BB. "Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response." J Cell Biochem 54, no. 4 (April 1994): 453-464. Full Text Link to Item
  - Sawaya, R, Tofilon, PJ, Mohanam, S, Ali-Osman, F, Liotta, LA, Stetler-Stevenson, WG, and Rao, JS. "Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes." Int J Cancer 56, no. 2 (January 15, 1994): 214-218. Link to Item
  - Ali-Osman, F, Berger, MS, Rairkar, A, and Stein, DE. "Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy." J Cell Biochem 54, no. 1 (January 1994): 11-19. Full Text Link to Item
  - Rao, JS, Steck, PA, Tofilon, P, Boyd, D, Ali-Osman, F, Stetler-Stevenson, WG, Liotta, LA, and Sawaya, R. "Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model." J Neurooncol 18, no. 2 (1994): 129-138. (Review) Link to Item
  - Ali-Osman, F, Berger, MS, Rajagopal, S, Spence, A, and Livingston, RB. "Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells." Cancer Res 53, no. 23 (December 1, 1993): 5663-5668. Link to Item
  - Mohanam, S, Sawaya, R, McCutcheon, I, Ali-Osman, F, Boyd, D, and Rao, JS. "Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody." Cancer Res 53, no. 18 (September 15, 1993): 4143-4147. Link to Item
  - Ishikawa, T, and Ali-Osman, F. "Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance." The Journal of Biological Chemistry 268, no. 27 (September 1993): 20116-20125.
  - Sriram, R, and Ali-Osman, F. "Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line." Biochem Mol Biol Int 30, no. 6 (August 1993): 1053-1060. Link to Item
  - Silbergeld, DL, Mayberg, MR, Berger, MS, Ali-Osman, F, Kelly, WA, and Shaw, CM. "Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations." J Neurooncol 16, no. 1 (April 1993): 39-46. Link to Item
  - Genka, S, Deutsch, J, Shetty, UH, Stahle, PL, John, V, Lieberburg, IM, Ali-Osman, F, Rapoport, SI, and Greig, NH. "Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil." Clin Exp Metastasis 11, no. 2 (March 1993): 131-140. Link to Item
  - Spence, AM, Berger, MS, Livingston, RB, Ali-Osman, F, and Griffin, B. "Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure." J Neurooncol 12, no. 2 (February 1992): 187-191. Link to Item
  - Silbergeld, DL, Ali-Osman, F, and Winn, HR. "Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells." J Neurosurg 75, no. 4 (October 1991): 604-612. Full Text Link to Item
  - Silbergeld, DL, and Ali-Osman, F. "Isolation and characterization of microvessels from normal brain and brain tumors." Journal of Neuro Oncology 11, no. 1 (August 1991): 49-55. Full Text
  - Ali-Osman, F, Stein, DE, and Renwick, A. "Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines." Cancer Res 50, no. 21 (November 1, 1990): 6976-6980. Link to Item
  - Ali-Osman, F, and Schofield, D. "Cellular and molecular studies in brain and nervous system oncology." Curr Opin Oncol 2, no. 4 (August 1990): 655-665. (Review) Link to Item
  - Srivenugopal, KS, and Ali-Osman, F. "Stimulation and inhibition of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced strand breaks and interstrand cross-linking in Col E1 plasmid deoxyribonucleic acid by polyamines and inorganic cations." Biochem Pharmacol 40, no. 3 (August 1, 1990): 473-479. Link to Item
  - Sriram, R, and Ali-Osman, F. "S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells." Anal Biochem 187, no. 2 (June 1990): 345-348. Link to Item
  - Ali-Osman, F, Srivenugopal, K, Berger, MS, and Stein, DE. "DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance." Anticancer Res 10, no. 3 (May 1990): 677-682. Link to Item
  - Canady, KS, Ali-Osman, F, and Rubel, EW. "Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells." Glia 3, no. 5 (January 1990): 368-374. Full Text
  - Sriram, R, and Ali-Osman, F. "S₁-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells." Analytical Biochemistry 187, no. 2 (1990): 345-348. Full Text
  - Ali-Osman, F, Caughlan, J, and Gray, GS. "Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione." Cancer Res 49, no. 21 (November 1, 1989): 5954-5958. Link to Item
  - Ali-Osman, F. "Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione." Cancer Res 49, no. 19 (October 1, 1989): 5258-5261. Link to Item
  - Ali-Osman, F, and Beltz, PA. "Optimization and characterization of the capillary human tumor clonogenic cell assay." Cancer Res 48, no. 3 (February 1, 1988): 715-724. Link to Item
  - Ali-Osman, F, Giblin, J, Dougherty, D, and Rosenblum, ML. "Application of in vivo and in vitro pharmacokinetics for physiologically relevant drug exposure in a human tumor clonogenic cell assay." Cancer Res 47, no. 14 (July 15, 1987): 3718-3724. Link to Item
  - Moezzi, J, Ali-Osman, F, and Murphy, MJ. "Rapid method for permanent slide preparation of colonies in soft agar cultures." Int J Cell Cloning 4, no. 5 (September 1986): 368-374. Full Text Link to Item
  - Moezzi, J, Ali-Osman, F, Nicholson, GL, Ungerleider, JS, and Murphy, MJ. "Relationship between histopathology and in vitro clonogenicity in breast cancer." Breast Cancer Res Treat 8, no. 2 (1986): 147-156. Link to Item
  - Hübner, GE, Ali-Osman, F, Kastner, M, Papadimitriou, C, and Maurer, HR. "Reculturing of cells from primary CFU-C colonies." Z Naturforsch C 40, no. 11-12 (November 1985): 891-897. Link to Item
  - Ali-Osman, F, Giblin, J, Berger, M, Murphy, MJ, and Rosenblum, ML. "Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas." Cancer Res 45, no. 9 (September 1985): 4185-4191. Link to Item
  - Ali-Osman, F, Rosenblum, ML, Giannini, DD, and Levin, VA. "Potential antiglioma activity of 9-hydroxy-2-N-methylellipticine as determined by pharmacological and human tumor clonogenic cell studies." Cancer Res 45, no. 7 (July 1985): 2988-2992. Link to Item
  - Ali-Osman, F, Giblin, J, and Berger, M. "In vitro bone marrow cytotoxicity of nitrosoureas: Possible role for carbamoylation." Proceedings of the American Association for Cancer Research VOL. 26 (January 1, 1985).
  - Berger, MS, Talcott, RE, Rosenblum, ML, Silva, M, AliOsman, F, and Smith, MT. "Use of quinones in brain-tumor therapy: Preliminary results of preclinical laboratory investigations." Journal of Toxicology and Environmental Health 16, no. 5 (1985): 713-719.
  - Dittmar, W, Klitschka, G, Braun, R, Ali-Osman, F, Meckert, C, and Maurer, HR. "In vitro and in vivo investigations for the development of cytostatic methylhydrazones." J Cancer Res Clin Oncol 110, no. 2 (1985): 110-114. Link to Item
  - Maurer, HR, Meckert, C, Ali-Osman, F, and Musil, J. "Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU)." Arzneimittelforschung 34, no. 9 (1984): 939-943. Link to Item
  - Ali Osman, F, Maurer, HR, and Bier, J. "In vitro cytostatic drug sensitivity testing in the human tumor stem cell assay: A modified method for the determination of the sensitivity index." Tumor Diagnostik Und Therapie 4, no. 1 (January 1, 1983): 1-6.
  - Ali-Osman, F, and Maurer, HR. "Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity." J Cancer Res Clin Oncol 106, no. 1 (1983): 17-20. Link to Item
  - Osman, FA, Bier, J, Bier, H, Siegel, T, Maurer, HR, and Ohanian, S. "Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity." International Journal of Cell Cloning 1, no. 2 (1983): 118-127.
  - Neumeier, R, Ali-Osman, F, and Maurer, HR. "Two different types of granulocyte colony-stimulating factor produced by bovine lung tissue." Blut 44, no. 1 (January 1982): 21-27. Link to Item
  - Maurer, HR, and Ali-Osman, F. "Tumor stem cell cloning in agar-containing capillaries." Naturwissenschaften 68, no. 7 (July 1981): 381-383. Link to Item
  - Ali-Osman, F, and Maurer, HR. "Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays." J Cancer Res Clin Oncol 98, no. 3 (1980): 221-231. Link to Item
  - Osman, FA, and Maurer, HR. "Comparative cell kinetic studies of the L1210 leukemic line differential, effects of cytostatics and a lymphocyte chalone extract on this cell line and on peripheral human lymphocytes after PHA-stimulation." Cell and Tissue Kinetics 13, no. 2 (January 1, 1980): 208-null.
- Book Sections
  - Buolamwini, JK, and Ali-Osman, F. "Dynamic docking study of the binding of 1-chloro-2,4-dinitrobenzene in the putative electrophile binding site of naturally occurring human glutathione s-transferase pi allelo-polymorphic proteins." In Biologically Active Natural Products: Pharmaceuticals, 188-198. January 1, 1999. Full Text
- Other Articles
  - Augustine, CK, Yoo, JS, Potti, A, Yoshimoto, Y, Zipfel, PA, Friedman, HS, Nevins, JR, Ali-Osman, F, and Tyler, DS. "Correction: Article on genomic and molecular profiling to predict response to temozolomide (Clinical Cancer Research (2009) 15, (502-510))." Clinical Cancer Research 15, no. 9 (May 1, 2009): 3240-null. Full Text
- Conference Papers
  - Amirian, ES, Armstrong, G, Zhou, R, Wrensch, M, Olson, S, Scheurer, M, Il'yasova, D, Lachance, D, Lau, C, Claus, E, Barnholtz-Sloan, J, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, R, Jenkins, R, Bernstein, J, Merrell, R, Davis, F, Lai, R, Shete, S, Amos, C, Melin, B, and Bondy, M. "DEMOGRAPHICS AND LIFESTYLE FACTORS IN GLIOMA RISK: A REPORT FROM THE GLIOMA INTERNATIONAL CASE-CONTROL STUDY." 21st Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology. Scottsdale, AZ. November 17, 2016 - November 20, 2016.: OXFORD UNIV PRESS INC, November 1, 2016. Link to Item
  - Advani, AS, Tse, W, Jia, X, Elson, P, Cooper, B, Ali-Osman, F, Park, J, Rao, AV, Rizzieri, DA, Wang, ES, Cotta, CV, Kalaycio, M, Sobecks, RM, Rouphail, B, Maciejewski, JP, Fensterl, J, Bailey, L, Carew, JS, Foster, B, Rush, ML, Adams, D, Griffiths, EA, and Sekeres, MA. "Long-Term Follow-up Results: A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed c-Kit Positive Acute Myeloid Leukemia (AML)." December 3, 2015. Link to Item
  - Lidsky, ME, Turley, RS, Speicher, P, Augustine, CK, Ali-Osman, F, and Tyler, DS. "Termination of BRAF Targeted Therapy Augments Tumor Growth in the Setting of Vemurafenib Resistance." 66th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO). National Harbor, MD. March 6, 2013 - March 9, 2013.: SPRINGER, February 1, 2013. Link to Item
  - Flores, RD, Rivera, F, Zink, J, Stoeppel, C, Ali-Osman, F, Liu, M-M, Minei, J, and Minshall, C. "ADRENOMEDULLIN (ADM) LEVELS IN BONCHOALVEOLAR LAVAGE (BAL) PREDICT VENTILATOR ASSOCIATED PNEUMONIA (VAP) IN PATIENTS WITH A HIGH CLINICAL PULMONARY INFECTION SCORE (CPIS)." December 2012. Link to Item
  - Advani, A, Cooper, B, Sowunmi, O, Elson, P, Ali-Osman, F, Park, J, Rao, A, Rizzieri, DA, Wang, ES, Cotta, C, Sekeres, MA, Kalaycio, M, Sobecks, R, Rouphail, B, Maciejewski, JP, Davis, R, Bailey, L, Foster, B, Rush, ML, Adams, D, and Tse, W. "A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed C-Kit Positive Acute Myeloid Leukemia (AML)." November 16, 2012. Link to Item
  - Antoun, GR, McLendon, R, Friedman, H, Friedman, A, Bigner, D, and Ali-Osman, F. "Abstract 1177: The mutational status of the p53 tumor suppressor gene is a determinant of GSTP1 expression and mediates GSTP1-dependent drug resistance in human glioblastoma." : American Association for Cancer Research (AACR), April 15, 2012. Full Text
  - Cao, X, Zhu, H, Bigner, D, Ali-Osman, F, and Lo, H-W. "GAIN-OF-FUNCTION tGLI1 TRANSCRIPTION FACTOR AUGMENTS ANCHORAGE-INDEPENDENT GROWTH OF MEDULLOBLASTOMA CELLS AND CONFERS THEIR RESISTANCE TO SMO INHIBITORS." May 2011. Link to Item
  - Cao, X, Zhu, H, Bigner, D, Ali-Osman, F, and Lo, H-W. "EGFR AND EGFRvIII UNDERGO STRESS- AND EGFR KINASE INHIBITOR-INDUCED MITOCHONDRIAL TRANSLOCALIZATION IN GLIOBLASTOMA: A POTENTIAL MECHANISM OF EGFR- AND EGFRvIII-DRIVEN ANTAGONISM OF APOPTOSIS AND DRUG RESPONSE." May 2011. Link to Item
  - Zhu, H, Cao, X, Keir, S, Bigner, D, Ali-Osman, F, and Lo, H-W. "UPREGULATION OF VEGF-A GENE EXPRESSION BY THE tGLI1 TRANSCRIPTION FACTOR CONTRIBUTES TO GLIOBLASTOMA ANGIOGENESIS." May 2011. Link to Item
  - Zhu, H, Cao, X, Keir, S, Ali-Osman, F, and Lo, H-W. "UNDERSTANDING AND TARGETING KINASE-INDEPENDENT ACTIVITY OF EGFR AND EGFRVIII TO OVERCOME GBM DRUG RESISTANCE." Advances in Inflammatory Bowel Diseases Crohns and Colitis Foundations National Clinical and Research Conference. Hollywood, FL. December 9, 2010 - December 12, 2010.: OXFORD UNIV PRESS INC, November 1, 2010. Link to Item
  - Ali-Osman, F, Owzar, K, Adams, B, Lipp, E, Herdon, J, Illyasova, D, Davis, F, Vick, N, Friedman, A, McClendon, R, Reardon, D, Friedman, H, Weale, M, and Bigner, D. "GENETIC DIVERSITY ASSOCIATED WITH SURVIVAL IN MALIGNANT GLIOMAS IDENTIFIED BY LINKAGE DISEQUILIBRIUM-BASED ANALYSIS OF HAPLOTYPE BLOCK REGIONS OF DNA REPAIR GENES." December 2009. Link to Item
  - Okamura, T, and Ali-Osman, F. "DIRECT TYROSINE PHOSPHORYLATION OF GSTP1 BY EGFR INDUCES JNK ACTIVATION IN GLIOBLASTOMA CELLS." 3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology. Yokohama, JAPAN. May 11, 2009 - May 14, 2009.: OXFORD UNIV PRESS INC, December 1, 2009. Link to Item
  - Lo, H-W, Cao, X, Zhu, H, and Ali-Osman, F. "CONSTITUTIVE STAT3 ACTIVATION FREQUENTLY COEXISTS WITH EGFR EXPRESSION IN HIGH-GRADE GLIOMAS AND TARGETING STAT3 SENSITIZES THEM TO ANTI-EGFR AND ALKYLATING AGENTS." 13th Annual Meeting of the Society-for-Neuro-Oncology (SNO). Las Vegas, NV. November 20, 2008 - November 23, 2008.: OXFORD UNIV PRESS INC, October 1, 2008. Link to Item
  - Lo, H-W, Stephenson, L, Cao, X, Pollock, R, Milas, M, and Ali-Osman, F. "IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN GSTP1 GENE AS A NOVEL TRANSCRIPTIONAL TARGET OF THE P53 TUMOR SUPPRESSOR GENE." 13th Annual Meeting of the Society-for-Neuro-Oncology (SNO). Las Vegas, NV. November 20, 2008 - November 23, 2008.: OXFORD UNIV PRESS INC, October 1, 2008. Link to Item
  - Okamura, T, Singh, S, Bigner, D, and Ali-Osman, F. "LIGAND-DEPENDENT ACTIVATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INDUCES EARLY DRUG RESISTANCE IN BRAIN TUMOR CELLS VIA ACTIVATION OF ITS DOWNSTREAM TARGET GLUTATHIONE S-TRANSFERASE P1." October 2008. Link to Item
  - Lo, H-W, Cao, X, Zhu, H, and Ali-Osman, F. "Stat3 constitutive activation is associated with glioma tumor grade: Pathway profiling and therapy." 12th Annual Meeting of the Society-for-Neuro-Oncology. Dallas, TX. November 15, 2007 - November 18, 2007.: DUKE UNIV PRESS, October 1, 2007. Link to Item
  - Lo, H-W, Cao, X, Zhu, H, and Ali-Osman, F. "Targeting constitutively activated stat3 sensitizes medulloblastomas to chemotherapeutic agents." 12th Annual Meeting of the Society-for-Neuro-Oncology. Dallas, TX. November 15, 2007 - November 18, 2007.: DUKE UNIV PRESS, October 1, 2007. Link to Item
  - Wang, J, Liu, R, Bond, M, Chen, M, Singh, S, Ali-Osman, F, Lefkowitz, RJ, Diehl, AM, Lyerly, HK, Barak, L, and Chen, W. "Targeting hedgehog signaling in medulloblastoma." October 2007. Link to Item
  - Ali-Osman, F. "Polymorphism of the promoter of the epidermal growth factor (EGF) gene in patients, its distribution and correlation with survival in glioma patients." 7th Congress of the European-Association-for-Neuro-Oncology (EANO). Vienna, AUSTRIA. September 14, 2006 - September 17, 2006.: DUKE UNIV PRESS, October 1, 2006. Link to Item
  - Okamura, T, Haystead, T, Bigner, DD, and Ali-Osman, F. "Glutathione S-transferase P1 (GSTP1) is a novel downstream target of Akt in human gliomas." October 2006. Link to Item
  - Yoo, J, Augustine, CK, Yoshimoto, Y, Petersen, RP, Pruitt, SK, Ali-Osman, F, and Tyler, DS. "Role of BAY 43-9006 in combination with temozolomide and melphalan in metastatic melanoma." February 2006. Link to Item
  - Wanko, SO, Gockerman, JP, Moore, JO, de Castro, C, Diehl, L, Pronitz, R, Gasparetto, C, Chute, J, Horwitz, M, Morris, A, Ali-Osman, F, Rao, A, Niedzweicki, D, Long, GD, Chao, NJ, and Rizzieri, DA. "Multimodal dose dense therapy for mantle cell lymphoma." November 16, 2005. Link to Item
  - Yoo, JS, Yoshimoto, Y, Petersen, RP, Pruitt, SK, Ali-Osman, F, and Tyler, DS. "Glutathione S-transferase as a marker of metastatic potential in malignant melanoma." : Elsevier BV, September 2005. Full Text
  - Ali-Osman, F, Herndon, JE, Stephenson, L, Davis, F, McCarthy, B, Reardon, D, Friedman, A, McClendon, R, Friedman, H, and Bigner, DD. "Prevalence and prognostic significance of polymorphisms at the glutathione S-transferase M1, M3, P1, and T1 gene loci in human astrocytomas." July 2005. Link to Item
  - Ali-Osman, F, Lo, H, Antoun, G, Friedman, A, Friedman, H, and Bigner, D. "A novel mechanism of PKA- and PKC-dependent drug resistance in human gliomas involving phosphorylation and metabolic activation of glutathione S-transferase P1 (GSTP1)." July 2005. Link to Item
  - Ishimoto, T, and Ali-Osman, F. "Pharmacogenetics of the human glutathione S-transferase P1 gene and tumor response to chemotherapy." November 2002. Link to Item
  - Scholl, R, Blandford, M, Ballard, L, Magee, JB, Williams, S, Robertson, M, Ali-Osman, F, Lemons, R, and Keller, C. "A high throughput fluorescent assay for the detection of glutathione S-transferase polymorphic alleles." October 2002. Link to Item

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