Francis Ali-Osman | Scholars@Duke

Francis Ali-Osman
Margaret Harris and David Silverman Professor of Neuro-Oncology Research

Current Appointments & Affiliations

Margaret Harris and David Silverman Professor of Neuro-Oncology Research, Neurosurgery, Neuro-Oncology, Neurosurgery 2004
Professor in Neurosurgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2017
Professor in Pathology, Pathology, Clinical Science Departments 2004
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003

Contact Information

199 Medical Science Research Building, Durham, NC 27710
Box 3156 Med Ctr, Durham, NC 27710
francis.aliosman@duke.edu (919) 681-5769

Background
Education, Training, & Certifications
- D.Sc., Free University of Berlin (Germany) 1982
Duke Appointment History
- Professor of Surgery, Surgery, Surgical Sciences, Surgery 2015 - 2017
- Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2003
Expertise
Global Scholarship
- Research
  - Ghana (Country)
Research
Selected Grants
- Duke SPORE in Brain Cancer awarded by National Institutes of Health 2014 - 2019
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- P53-dependent GSTP1 Gene Regulation and Glioma Drug Resistance awarded by National Institutes of Health 2010 - 2015
- Protein Kinase C and GSTP1 interactions in glioma drug resistance awarded by National Institutes of Health 2008 - 2014
- NCI Howard Temin Award (K01) Transition awarded by National Institutes of Health 2006 - 2012
- Novel Targeted Therapeutics for CNS Malignancies awarded by National Institutes of Health 2006 - 2011
- Radionuclide-based Molecular Imaging of the DNA Repair Protein AGT awarded by National Institutes of Health 2009 - 2011
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- DNA Methylation and GSTP1 Gene Regulation in Gliomas awarded by National Institutes of Health 2002 - 2008
- Planning a Duke Academic Public Private Partnership Program (AP4) Center awarded by National Cancer Institute 2004 - 2006
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Advani, AS, Tse, W, Jia, X, Elson, P, Cooper, B, Ali-Osman, F, Park, J, Rao, AV, Rizzieri, DA, Wang, ES, Cotta, CV, Kalaycio, M, Sobecks, RM, Rouphail, B, Maciejewski, JP, Fensterl, J, Bailey, L, Carew, JS, Foster, B, Rush, ML, Adams, D, Griffiths, EA, and Sekeres, MA. "Long-Term Follow-up Results: A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed c-Kit Positive Acute Myeloid Leukemia (AML)." December 3, 2015. Link to Item
  - Advani, A, Cooper, B, Sowunmi, O, Elson, P, Ali-Osman, F, Park, J, Rao, A, Rizzieri, DA, Wang, ES, Cotta, C, Sekeres, MA, Kalaycio, M, Sobecks, R, Rouphail, B, Maciejewski, JP, Davis, R, Bailey, L, Foster, B, Rush, ML, Adams, D, and Tse, W. "A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed C-Kit Positive Acute Myeloid Leukemia (AML)." November 16, 2012. Link to Item
  - Antoun, GR, McLendon, R, Friedman, H, Friedman, A, Bigner, D, and Ali-Osman, F. "The mutational status of the p53 tumor suppressor gene is a determinant of GSTP1 expression and mediates GSTP1-dependent drug resistance in human glioblastoma." April 15, 2012. Full Text Link to Item
  - Cao, X, Zhu, H, Bigner, D, Ali-Osman, F, and Lo, H-W. "GAIN-OF-FUNCTION tGLI1 TRANSCRIPTION FACTOR AUGMENTS ANCHORAGE-INDEPENDENT GROWTH OF MEDULLOBLASTOMA CELLS AND CONFERS THEIR RESISTANCE TO SMO INHIBITORS." May 2011. Link to Item
  - Cao, X, Zhu, H, Bigner, D, Ali-Osman, F, and Lo, H-W. "EGFR AND EGFRvIII UNDERGO STRESS- AND EGFR KINASE INHIBITOR-INDUCED MITOCHONDRIAL TRANSLOCALIZATION IN GLIOBLASTOMA: A POTENTIAL MECHANISM OF EGFR- AND EGFRvIII-DRIVEN ANTAGONISM OF APOPTOSIS AND DRUG RESPONSE." May 2011. Link to Item
  - Zhu, H, Cao, X, Keir, S, Bigner, D, Ali-Osman, F, and Lo, H-W. "UPREGULATION OF VEGF-A GENE EXPRESSION BY THE tGLI1 TRANSCRIPTION FACTOR CONTRIBUTES TO GLIOBLASTOMA ANGIOGENESIS." May 2011. Link to Item
  - Ali-Osman, F, Owzar, K, Adams, B, Lipp, E, Herdon, J, Illyasova, D, Davis, F, Vick, N, Friedman, A, McClendon, R, Reardon, D, Friedman, H, Weale, M, and Bigner, D. "GENETIC DIVERSITY ASSOCIATED WITH SURVIVAL IN MALIGNANT GLIOMAS IDENTIFIED BY LINKAGE DISEQUILIBRIUM-BASED ANALYSIS OF HAPLOTYPE BLOCK REGIONS OF DNA REPAIR GENES." December 2009. Link to Item
  - Okamura, T, Singh, S, Bigner, D, and Ali-Osman, F. "LIGAND-DEPENDENT ACTIVATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INDUCES EARLY DRUG RESISTANCE IN BRAIN TUMOR CELLS VIA ACTIVATION OF ITS DOWNSTREAM TARGET GLUTATHIONE S-TRANSFERASE P1." October 2008. Link to Item
  - Wang, J, Liu, R, Bond, M, Chen, M, Singh, S, Ali-Osman, F, Lefkowitz, RJ, Diehl, AM, Lyerly, HK, Barak, L, and Chen, W. "Targeting hedgehog signaling in medulloblastoma." October 2007. Link to Item
  - Okamura, T, Haystead, T, Bigner, DD, and Ali-Osman, F. "Glutathione S-transferase P1 (GSTP1) is a novel downstream target of Akt in human gliomas." October 2006. Link to Item
  - Yoo, J, Augustine, CK, Yoshimoto, Y, Petersen, RP, Pruitt, SK, Ali-Osman, F, and Tyler, DS. "Role of BAY 43-9006 in combination with temozolomide and melphalan in metastatic melanoma." February 2006. Link to Item
  - Wanko, SO, Gockerman, JP, Moore, JO, de Castro, C, Diehl, L, Pronitz, R, Gasparetto, C, Chute, J, Horwitz, M, Morris, A, Ali-Osman, F, Rao, A, Niedzweicki, D, Long, GD, Chao, NJ, and Rizzieri, DA. "Multimodal dose dense therapy for mantle cell lymphoma." November 16, 2005. Link to Item
  - Yoo, JS, Yoshimoto, Y, Petersen, RP, Pruitt, SK, Ali-Osman, F, and Tyler, DS. "Glutathione S-transferase as a marker of metastatic potential in malignant melanoma." September 2005. Full Text Link to Item
  - Ali-Osman, F, Herndon, JE, Stephenson, L, Davis, F, McCarthy, B, Reardon, D, Friedman, A, McClendon, R, Friedman, H, and Bigner, DD. "Prevalence and prognostic significance of polymorphisms at the glutathione S-transferase M1, M3, P1, and T1 gene loci in human astrocytomas." July 2005. Link to Item
  - Ali-Osman, F, Lo, H, Antoun, G, Friedman, A, Friedman, H, and Bigner, D. "A novel mechanism of PKA- and PKC-dependent drug resistance in human gliomas involving phosphorylation and metabolic activation of glutathione S-transferase P1 (GSTP1)." July 2005. Link to Item
- Journal Articles
  - Madala, HR, Punganuru, SR, Ali-Osman, F, Zhang, R, and Srivenugopal, KS. "Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts." Oncotarget 9, no. 3 (January 2018): 3459-3482. Full Text
  - Melin, BS, Barnholtz-Sloan, JS, Wrensch, MR, Johansen, C, Il'yasova, D, Kinnersley, B, Ostrom, QT, Labreche, K, Chen, Y, Armstrong, G, Liu, Y, Eckel-Passow, JE, Decker, PA, Labussière, M, Idbaih, A, Hoang-Xuan, K, Di Stefano, A-L, Mokhtari, K, Delattre, J-Y, Broderick, P, Galan, P, Gousias, K, Schramm, J, Schoemaker, MJ, Fleming, SJ, Herms, S, Heilmann, S, Nöthen, MM, Wichmann, H-E, Schreiber, S, Swerdlow, A, Lathrop, M, Simon, M, Sanson, M, Andersson, U, Rajaraman, P, Chanock, S, and Linet, M et al. "Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors." Nature genetics 49, no. 5 (May 2017): 789-794. Full Text
  - Paranjpe, A, Bailey, NI, Konduri, S, Bobustuc, GC, Ali-Osman, F, Yusuf, MA, Punganuru, SR, Madala, HR, Basak, D, Mostofa, A, and Srivenugopal, KS. "New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy." Journal of biomedical research 30, no. 5 (September 2016): 393-410. Full Text
  - Amirian, ES, Scheurer, ME, Zhou, R, Wrensch, MR, Armstrong, GN, Lachance, D, Olson, SH, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Jenkins, RB, Bernstein, JL, Merrell, RT, Davis, FG, Lai, R, Shete, S, Amos, CI, Melin, BS, and Bondy, ML. "History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC)." Cancer medicine 5, no. 6 (June 2016): 1352-1358. Full Text
  - Amirian, ES, Zhou, R, Wrensch, MR, Olson, SH, Scheurer, ME, Il'yasova, D, Lachance, D, Armstrong, GN, McCoy, LS, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Bernstein, JL, Merrell, RT, Davis, FG, Lai, R, Shete, S, Amos, CI, Melin, BS, and Bondy, ML. "Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 25, no. 2 (February 2016): 282-290. Full Text
  - Amirian, ES, Armstrong, GN, Zhou, R, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Davis, FG, Lai, R, Shete, S, Amos, CI, Scheurer, ME, Aldape, K, Alafuzoff, I, Brännström, T, Broholm, H, Collins, P, Giannini, C, Rosenblum, M, Tihan, T, Melin, BS, and Bondy, ML. "The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium." American journal of epidemiology 183, no. 2 (January 2016): 85-91. Full Text
  - Mangram, AJ, Oguntodu, OF, Hollingworth, AK, Prokuski, L, Steinstra, A, Collins, M, Sucher, JF, Ali-Osman, F, and Dzandu, JK. "Geriatric trauma G-60 falls with hip fractures: A pilot study of acute pain management using femoral nerve fascia iliac blocks." The journal of trauma and acute care surgery 79, no. 6 (December 2015): 1067-1072. Full Text
  - Okamura, T, Antoun, G, Keir, ST, Friedman, H, Bigner, DD, and Ali-Osman, F. "Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells." The Journal of biological chemistry 290, no. 52 (December 2015): 30866-30878. Full Text
  - Brown, KE, Chagoya, G, Kwatra, SG, Yen, T, Keir, ST, Cooter, M, Hoadley, KA, Rasheed, A, Lipp, ES, Mclendon, R, Ali-Osman, F, Bigner, DD, Sampson, JH, and Kwatra, MM. "Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development." Journal of neurochemistry 133, no. 5 (June 2015): 730-738. Full Text
  - Jalali, A, Amirian, ES, Bainbridge, MN, Armstrong, GN, Liu, Y, Tsavachidis, S, Jhangiani, SN, Plon, SE, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Davis, FG, Lai, R, Shete, S, Aldape, K, Amos, CI, Muzny, DM, Gibbs, RA, Melin, BS, and Bondy, ML. "Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium." Scientific reports 5 (February 5, 2015): 8278-. Full Text
  - Bainbridge, MN, Armstrong, GN, Gramatges, MM, Bertuch, AA, Jhangiani, SN, Doddapaneni, H, Lewis, L, Tombrello, J, Tsavachidis, S, Liu, Y, Jalali, A, Plon, SE, Lau, CC, Parsons, DW, Claus, EB, Barnholtz-Sloan, J, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Walsh, KM, Davis, FG, Lai, R, Shete, S, Aldape, K, Amos, CI, Thompson, PA, Muzny, DM, Gibbs, RA, Melin, BS, and Bondy, ML et al. "Germline mutations in shelterin complex genes are associated with familial glioma." JNCI Journal of the National Cancer Institute 107, no. 1 (January 2015): 384-. Full Text
  - Brown, KE, Chagoya, G, Kwatra, SG, Yen, T, Keir, ST, Cooter, M, Hoadley, KA, Rasheed, A, Lipp, ES, McLendon, R, Ali-Osman, F, Bigner, DD, Sampson, JH, and Kwatra, MM. "Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: Implications for drug development." Journal of Neurochemistry 133, no. 5 (2015): 730-738. Full Text
  - Lidsky, M, Antoun, G, Speicher, P, Adams, B, Turley, R, Augustine, C, Tyler, D, and Ali-Osman, F. "Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells." The Journal of biological chemistry 289, no. 40 (October 2014): 27714-27726. Full Text
  - Paranjpe, A, Zhang, R, Ali-Osman, F, Bobustuc, GC, and Srivenugopal, KS. "Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage." Carcinogenesis 35, no. 3 (March 2014): 692-702. Full Text Link to Item
  - Kinev, AV, Levering, V, Young, K, Ali-Osman, F, Truskey, GA, Dewhirst, MW, and Il'yasova, D. "Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose." Cancer Invest 31, no. 5 (June 2013): 359-364. Full Text Link to Item
  - Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 conjugation is activated in human astrocytic brain tumors and is required for glioblastoma cell survival (vol 104, pg 70, 2013)." CANCER SCIENCE 104, no. 2 (February 2013): 274-274. Full Text Link to Item
  - Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Sci 104, no. 1 (January 2013): 70-77. Full Text Link to Item
  - Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Science 104, no. 1 (2013): 70-77. Full Text
  - Turley, RS, Lidsky, ME, Tyler, DS, and Ali-Osman, F. "Abstract 2012: MAP kinase activation and suppression of anti-apoptotic Bcl-2 family members are associated with induction of apoptotic death in melanoma cells following down-regulation of glutathione S-transferase P1." Cancer Research 72, no. 8 Supplement (April 15, 2012): 2012-2012. Full Text
  - Lachance, DH, Yang, P, Johnson, DR, Decker, PA, Kollmeyer, TM, McCoy, LS, Rice, T, Xiao, Y, Ali-Osman, F, Wang, F, Stoddard, SM, Sprau, DJ, Kosel, ML, Wiencke, JK, Wiemels, JL, Patoka, JS, Davis, F, McCarthy, B, Rynearson, AL, Worra, JB, Fridley, BL, O'Neill, BP, Buckner, JC, Il'yasova, D, Jenkins, RB, and Wrensch, MR. "Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking." Am J Epidemiol 174, no. 5 (September 1, 2011): 574-581. Full Text Link to Item
  - Turley, RS, Liu, J, Tyler, D, and Ali-Osman, F. "Abstract 1635: Short hairpin RNA-mediated transcriptional suppression of glutathione S-transferase P1 suppresses growth and induces apoptosis through altered MAP kinase signaling in melanoma cells." Cancer Research 71, no. 8 Supplement (April 15, 2011): 1635-1635. Full Text
  - Cao, X, Zhu, H, Ali-Osman, F, and Lo, H-W. "EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. (Published online)" Mol Cancer 10 (March 9, 2011): 26-. Full Text Link to Item
  - McCarthy, BJ, Rankin, K, Il'yasova, D, Erdal, S, Vick, N, Ali-Osman, F, Bigner, DD, and Davis, F. "Assessment of type of allergy and antihistamine use in the development of glioma." Cancer Epidemiol Biomarkers Prev 20, no. 2 (February 2011): 370-378. Full Text Link to Item
  - Advani, AS, Shadman, M, Ali-Osman, F, Barker, A, Rybicki, L, Kalaycio, M, Sekeres, MA, de Castro, CM, Diehl, LF, Moore, JO, Beaven, A, Copelan, E, Sobecks, R, Talea, P, and Rizzieri, DA. "A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse." Clin Lymphoma Myeloma Leuk 10, no. 6 (December 2010): 473-476. Full Text Link to Item
  - Jones, LW, Ali-Osman, F, Lipp, E, Marcello, JE, McCarthy, B, McCoy, L, Rice, T, Wrensch, M, and Il'yasova, D. "Association between body mass index and mortality in patients with glioblastoma mutliforme." Cancer Causes Control 21, no. 12 (December 2010): 2195-2201. Full Text Link to Item
  - Cui, B, Johnson, SP, Bullock, N, Ali-Osman, F, Bigner, DD, and Friedman, HS. "Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells." J Biomed Res 24, no. 6 (November 2010): 424-435. Full Text Link to Item
  - Singh, S, Okamura, T, and Ali-Osman, F. "Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells." Biochem Pharmacol 80, no. 9 (November 1, 2010): 1343-1355. Full Text Link to Item
  - Toshimitsu, H, Yoshimoto, Y, Augustine, CK, Padussis, JC, Yoo, JS, Angelica Selim, M, Pruitt, SK, Friedman, HS, Ali-Osman, F, and Tyler, DS. "Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma." Ann Surg Oncol 17, no. 8 (August 2010): 2247-2254. Full Text Link to Item
  - Zhu, H, Cao, X, Ali-Osman, F, Keir, S, and Lo, H-W. "EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity." Cancer Lett 294, no. 1 (August 1, 2010): 101-110. Full Text Link to Item
  - Augustine, CK, Toshimitsu, H, Jung, S-H, Zipfel, PA, Yoo, JS, Yoshimoto, Y, Selim, MA, Burchette, J, Beasley, GM, McMahon, N, Padussis, J, Pruitt, SK, Ali-Osman, F, and Tyler, DS. "Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy." Mol Cancer Ther 9, no. 7 (July 2010): 2090-2101. Full Text Link to Item
  - Crout, CA, Koh, L-P, Gockerman, JP, Moore, JO, Decastro, C, Long, GD, Diehl, L, Gasparetto, C, Niedzwiecki, D, Edwards, J, Prosnitz, L, Horwitz, M, Chute, J, Morris, A, Davis, P, Beaven, A, Chao, NJ, Ali-Osman, F, and Rizzieri, DA. "Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy." Cancer Invest 28, no. 6 (July 2010): 654-660. Full Text Link to Item
  - Augustine, CK, Jung, S-H, Sohn, I, Yoo, JS, Yoshimoto, Y, Olson, JA, Friedman, HS, Ali-Osman, F, and Tyler, DS. "Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma." Mol Cancer Ther 9, no. 4 (April 2010): 779-790. Full Text Link to Item
  - Lo, H-W, Cao, X, Zhu, H, and Ali-Osman, F. "Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes." Mol Cancer Res 8, no. 2 (February 2010): 232-245. Full Text Link to Item
  - Lo, H-W, Zhu, H, Cao, X, Aldrich, A, and Ali-Osman, F. "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion." Cancer Res 69, no. 17 (September 1, 2009): 6790-6798. Link to Item
  - Okamura, T, Singh, S, Buolamwini, J, Haystead, T, Friedman, H, Bigner, D, and Ali-Osman, F. "Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor." J Biol Chem 284, no. 25 (June 19, 2009): 16979-16989. Full Text Link to Item
  - Cui, B, Johnson, SP, Bullock, N, Ali-Osman, F, Bigner, DD, and Friedman, HS. "Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway." Mol Pharmacol 75, no. 6 (June 2009): 1356-1363. Full Text Link to Item
  - Il'yasova, D, McCarthy, B, Marcello, J, Schildkraut, JM, Moorman, PG, Krishnamachari, B, Ali-Osman, F, Bigner, DD, and Davis, F. "Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls." Cancer Epidemiol Biomarkers Prev 18, no. 4 (April 2009): 1232-1238. Full Text Link to Item
  - Okamura, T, Singh, S, Buolamwini, JK, Friedman, HS, Bigner, DD, and Ali-Osman, F. "EGF RECEPTOR TYROSINE KINASE MEDIATES A NOVEL PATHWAY OF DRUG RESISTANCE IN MALIGNANT GLIOMAS VIA TYROSINE PHOSPHORYLATION AND FUNCTIONAL ACTIVATION OF GLUTATHIONE S-TRANSFERASE P1." NEURO-ONCOLOGY 11, no. 2 (April 2009): 218-218. Link to Item
  - Augustine, CK, Yoo, JS, Potti, A, Yoshimoto, Y, Zipfel, PA, Friedman, HS, Nevins, JR, Ali-Osman, F, and Tyler, DS. "Genomic and molecular profiling predicts response to temozolomide in melanoma." Clin Cancer Res 15, no. 2 (January 15, 2009): 502-510. Full Text Link to Item
  - Lo, H-W, Cao, X, Zhu, H, and Ali-Osman, F. "Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators." Clin Cancer Res 14, no. 19 (October 1, 2008): 6042-6054. Full Text Link to Item
  - Maxwell, JA, Johnson, SP, McLendon, RE, Lister, DW, Horne, KS, Rasheed, A, Quinn, JA, Ali-Osman, F, Friedman, AH, Modrich, PL, Bigner, DD, and Friedman, HS. "Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma." Clin Cancer Res 14, no. 15 (August 1, 2008): 4859-4868. Full Text Link to Item
  - Xie, T-X, Aldape, KD, Gong, W, Kanzawa, T, Suki, D, Kondo, S, Lang, F, Ali-Osman, F, Sawaya, R, and Huang, S. "Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor." Int J Oncol 33, no. 1 (July 2008): 5-15. Link to Item
  - Augustine, CK, Jung, S, Potti, A, Sohn, I, Yoo, JS, Zipfel, P, Jr, OJ, Ali-Osman, F, Nevins, JR, and Tyler, DS. "Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma." JOURNAL OF CLINICAL ONCOLOGY 26, no. 15 (May 20, 2008). Full Text Link to Item
  - Augustine, CK, Jung, S, Potti, A, Sohn, I, Yoo, JS, Zipfel, P, Olson, J, Ali-Osman, F, Nevins, JR, and Tyler, DS. "Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma." J Clin Oncol 26, no. 15_suppl (May 20, 2008): 9077-. Link to Item
  - Lo, H-W, Stephenson, L, Cao, X, Milas, M, Pollock, R, and Ali-Osman, F. "Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene." Mol Cancer Res 6, no. 5 (May 2008): 843-850. Full Text Link to Item
  - Lo, H-W, and Ali-Osman, F. "Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance." Curr Opin Pharmacol 7, no. 4 (August 2007): 367-374. (Review) Full Text Link to Item
  - Yoshimoto, Y, Augustine, CK, Yoo, JS, Zipfel, PA, Selim, MA, Pruitt, SK, Friedman, HS, Ali-Osman, F, and Tyler, DS. "Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents." Mol Cancer Ther 6, no. 5 (May 2007): 1492-1500. Full Text Link to Item
  - Tew, KD, and Ali-Osman, F. "Redox pathways in cancer drug discovery." Current Opinion in Pharmacology 7, no. 4 (2007): 353-354. Full Text
  - Maxwell, JA, Johnson, SP, Quinn, JA, McLendon, RE, Ali-Osman, F, Friedman, AH, Herndon, JE, Bierau, K, Bigley, J, Bigner, DD, and Friedman, HS. "Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma." Mol Cancer Ther 5, no. 10 (October 2006): 2531-2539. Full Text Link to Item
  - Cheng, CL, Johnson, SP, Keir, ST, Quinn, JA, Ali-Osman, F, Szabo, C, Li, H, Salzman, AL, Dolan, ME, Modrich, P, Bigner, DD, and Friedman, HS. "Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft." Mol Cancer Ther 4, no. 9 (September 2005): 1364-1368. Full Text Link to Item
  - Shou, J, Srivenugopal, KS, Mullapudi, SRS, Jr, FFL, Rao, JS, and Ali-Osman, F. "Erratum: Enforced expression of wild-type p53 curtails the transcription of the O⁶-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents (Clinical Cancer Research (May 1, 2001) 7 (1398-1409))." Clinical Cancer Research 11, no. 6 (2005): 2449--. Full Text
  - Lo, H-W, Antoun, GR, and Ali-Osman, F. "The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells." Cancer Res 64, no. 24 (December 15, 2004): 9131-9138. Full Text Link to Item
  - Xie, T-X, Wei, D, Liu, M, Gao, AC, Ali-Osman, F, Sawaya, R, and Huang, S. "Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis." Oncogene 23, no. 20 (April 29, 2004): 3550-3560. Full Text Link to Item
  - Okcu, MF, Selvan, M, Wang, L-E, Stout, L, Erana, R, Airewele, G, Adatto, P, Hess, K, Ali-Osman, F, Groves, M, Yung, AWK, Levin, VA, Wei, Q, and Bondy, M. "Glutathione S-transferase polymorphisms and survival in primary malignant glioma." Clinical cancer research : an official journal of the American Association for Cancer Research 10, no. 8 (April 2004): 2618-2625. Full Text
  - Barnette, P, Scholl, R, Blandford, M, Ballard, L, Tsodikov, A, Magee, J, Williams, S, Robertson, M, Ali-Osman, F, Lemons, R, and Keller, C. "High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population." Cancer Epidemiol Biomarkers Prev 13, no. 2 (February 2004): 304-313. Link to Item
  - Konduri, SD, Srivenugopal, KS, Yanamandra, N, Dinh, DH, Olivero, WC, Gujrati, M, Foster, DC, Kisiel, W, Ali-Osman, F, Kondraganti, S, Lakka, SS, and Rao, JS. "Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells." Oncogene 22, no. 29 (July 17, 2003): 4509-4516. Full Text Link to Item
  - Wang, Y, Spitz, MR, Schabath, MB, Ali-Osman, F, Mata, H, and Wu, X. "Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study." Lung Cancer 40, no. 1 (April 2003): 25-32. Link to Item
  - Zheng, T, Holford, TR, Zahm, SH, Owens, PH, Boyle, P, Zhang, Y, Zhang, B, Wise, JP, Stephenson, LP, and Ali-Osman, F. "Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk." Br J Cancer 88, no. 1 (January 13, 2003): 58-62. Full Text Link to Item
  - Ishimoto, TM, and Ali-Osman, F. "Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli." Pharmacogenetics 12, no. 7 (October 2002): 543-553. Link to Item
  - Zheng, T, Holford, TR, Zahm, SH, Owens, PH, Boyle, P, Zhang, Y, Wise, JP, Stephenson, LP, and Ali-Osman, F. "Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States)." Cancer Causes Control 13, no. 7 (September 2002): 637-645. Link to Item
  - Srivenugopal, KS, and Ali-Osman, F. "The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein." Oncogene 21, no. 38 (August 29, 2002): 5940-5945. Full Text Link to Item
  - Srivenugopal, KS, Mullapudi, SRS, and Ali-Osman, F. "Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay." Cancer Lett 181, no. 1 (July 8, 2002): 87-93. Link to Item
  - Bacolod, MD, Johnson, SP, Ali-Osman, F, Modrich, P, Bullock, NS, Colvin, OM, Bigner, DD, and Friedman, HS. "Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma." Mol Cancer Ther 1, no. 9 (July 2002): 727-736. Link to Item
  - Shou, J, Ali-Osman, F, Multani, AS, Pathak, S, Fedi, P, and Srivenugopal, KS. "Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA." Oncogene 21, no. 6 (January 31, 2002): 878-889. Full Text Link to Item
  - Konduri, SD, Osman, FA, Rao, CN, Srinivas, H, Yanamandra, N, Tasiou, A, Dinh, DH, Olivero, WC, Gujrati, M, Foster, DC, Kisiel, W, Kouraklis, G, and Rao, JS. "Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas." Oncogene 21, no. 6 (2002): 921-928. Full Text
  - Lo, H-W, and Ali-Osman, F. "Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation." J Cell Biochem 87, no. 1 (2002): 103-116. Full Text Link to Item
  - Mohanam, S, Jasti, SL, Kondraganti, SR, Chandrasekar, N, Lakka, SS, Kin, Y, Fuller, GN, Yung, AW, Kyritsis, AP, Dinh, DH, Olivero, WC, Gujrati, M, Ali-Osman, F, and Rao, JS. "Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells." Oncogene 20, no. 28 (June 21, 2001): 3665-3673. Full Text Link to Item
  - Srivenugopal, KS, Shou, J, Mullapudi, SR, Lang, FF, Rao, JS, and Ali-Osman, F. "Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents." Clin Cancer Res 7, no. 5 (May 2001): 1398-1409. Link to Item
  - Lakka, SS, Rajagopal, R, Rajan, MK, Mohan, PM, Adachi, Y, Dinh, DH, Olivero, WC, Gujrati, M, Ali-Osman, F, Roth, JA, Yung, WK, Kyritsis, AP, and Rao, JS. "Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines." Clin Cancer Res 7, no. 4 (April 2001): 1087-1093. Link to Item
  - Ali-Osman, F, Srivenugopal, K, and Sawaya, R. "The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents." N Engl J Med 344, no. 9 (March 1, 2001): 687-. (Letter) Link to Item
  - Maugard, CM, Charrier, J, Pitard, A, Campion, L, Akande, O, Pleasants, L, and Ali-Osman, F. "Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier." Int J Cancer 91, no. 3 (February 1, 2001): 334-339. Link to Item
  - Buckner, JC, Moynihan, TJ, Quinn, DI, Schlegel, U, Ali-Osman, F, Srivenugopal, K, Sawaya, R, Esteller, M, Herman, JG, and Weinstein, JN. "The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents [1] (multiple letters)." New England Journal of Medicine 344, no. 9 (2001): 686-688. Full Text
  - Lo, H-W, and Ali-Osman, F. "The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site." Chemico-Biological Interactions 133, no. 1-3 (2001): 320-321.
  - Kondraganti, S, Mohanam, S, Chintala, SK, Kin, Y, Jasti, SL, Nirmala, C, Lakka, SS, Adachi, Y, Kyritsis, AP, Ali-Osman, F, Sawaya, R, Fuller, GN, and Rao, JS. "Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion." Cancer Res 60, no. 24 (December 15, 2000): 6851-6855. Link to Item
  - Nirmala, C, Jasti, SL, Sawaya, R, Kyritsis, AP, Konduri, SD, Ali-Osman, F, Rao, JS, and Mohanam, S. "Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions." Int J Cancer 88, no. 5 (December 1, 2000): 766-771. Link to Item
  - Mullapudi, SR, Ali-Osman, F, Shou, J, and Srivenugopal, KS. "DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells." Biochem J 351 Pt 2 (October 15, 2000): 393-402. Link to Item
  - Ramachandran, S, Hoban, PR, Ichii-Jones, F, Pleasants, L, Ali-Osman, F, Lear, JT, Smith, AG, Bowers, B, Jones, PW, Fryer, AA, and Strange, RC. "Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours." Pharmacogenetics 10, no. 6 (August 2000): 545-556. Link to Item
  - Antoun, G, Baylin, SB, and Ali-Osman, F. "DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA." J Cell Biochem 77, no. 3 (April 2000): 372-381. Link to Item
  - Srivenugopal, KS, Mullapudi, SR, Shou, J, Hazra, TK, and Ali-Osman, F. "Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells." Cancer Res 60, no. 2 (January 15, 2000): 282-287. Link to Item
  - Chandrasekar, N, Jasti, S, Alfred-Yung, WK, Ali-Osman, F, Dinh, DH, Olivero, WC, Gujrati, M, Kyritsis, AP, Nicolson, GL, Rao, JS, and Mohanam, S. "Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions." Clin Exp Metastasis 18, no. 4 (2000): 337-342. Link to Item
  - Lakka, SS, Jasti, SL, Kyritsis, AP, Yung, WK, Ali-Osman, F, Nicolson, GL, and Rao, JS. "Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades." Clin Exp Metastasis 18, no. 3 (2000): 245-252. Link to Item
  - Multani, AS, Ozen, M, Sen, S, Mandal, AK, Price, JE, Fan, D, Radinsky, R, Ali-Osman, F, Von Eschenbach, AC, Fidler, IJ, and Pathak, S. "Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin." Int J Oncol 15, no. 3 (September 1999): 423-429. Link to Item
  - Chan, JY, and Ali-Osman, F. "In vitro repair synthesis of BCNU-induced DNA damage." Cancer Biochem Biophys 16, no. 3 (October 1998): 273-286. Link to Item
  - Keller, C, and Ali-Osman, F. "Translational inhibition of messenger RNA of the human pi class glutathione S-transferase by antisense oligodeoxyribonucleotides." Chem Biol Interact 111-112 (April 24, 1998): 307-323. Link to Item
  - Lo, HW, and Ali-Osman, F. "Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line." Chem Biol Interact 111-112 (April 24, 1998): 91-102. Link to Item
  - Anderson, CM, Buzaid, AC, Sussman, J, Lee, JJ, Ali-Osman, F, Braunschweiger, PG, Plager, C, Bedikian, A, Papadopoulos, N, Eton, O, Legha, SS, and Grimm, EA. "Nitric oxide and neopterin levels and clinical response in stage III melanoma patients receiving concurrent biochemotherapy." Melanoma Res 8, no. 2 (April 1998): 149-155. Link to Item
  - Buzaid, AC, Ali-Osman, F, Akande, N, Grimm, EA, Lee, JJ, Bedikian, A, Eton, O, Papadopoulos, N, Plager, C, Legha, SS, and Benjamin, RS. "DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma." Melanoma Res 8, no. 2 (April 1998): 145-148. Link to Item
  - Lo, HW, and Ali-Osman, F. "Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements." J Biol Chem 272, no. 52 (December 26, 1997): 32743-32749. Link to Item
  - Ali-Osman, F, Brunner, JM, Kutluk, TM, and Hess, K. "Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas." Clin Cancer Res 3, no. 12 Pt 1 (December 1997): 2253-2261. Link to Item
  - Friedman, HS, Johnson, SP, Dong, Q, Schold, SC, Rasheed, BK, Bigner, SH, Ali-Osman, F, Dolan, E, Colvin, OM, Houghton, P, Germain, G, Drummond, JT, Keir, S, Marcelli, S, Bigner, DD, and Modrich, P. "Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft." Cancer Res 57, no. 14 (July 15, 1997): 2933-2936. Link to Item
  - Srivenugopal, KS, and Ali-Osman, F. "Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues." Cancer Lett 117, no. 1 (July 15, 1997): 105-111. Link to Item
  - Chintala, SK, Ali-Osman, F, Mohanam, S, Rayford, A, Go, Y, Gokaslan, ZL, Gagercas, E, Venkaiah, B, Sawaya, R, Nicolson, GL, and Rao, JS. "Effect of cisplatin and BCNU on MMP-2 levels in human glioblastoma cell lines in vitro." Clin Exp Metastasis 15, no. 4 (July 1997): 361-367. Link to Item
  - Go, Y, Chintala, SK, Rayford, A, Gagercas, E, Ali-Osman, F, Venkaiah, B, Sawaya, R, Gokaslan, Z, Nicolson, GL, and Rao, JS. "Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro." Clin Exp Metastasis 15, no. 4 (July 1997): 447-452. Link to Item
  - Ali-Osman, F, Akande, O, Antoun, G, Mao, JX, and Buolamwini, J. "Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins." J Biol Chem 272, no. 15 (April 11, 1997): 10004-10012. Link to Item
  - Brandt, TY, and Ali-Osman, F. "Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells." Toxicol Appl Pharmacol 143, no. 1 (March 1997): 22-29. Full Text Link to Item
  - Ali-Osman, F, Brunner, JM, Kutluk, TM, and Hess, K. "Prognostic significance of glutathione S-transferase π expression and subcellular localization in human gliomas." Clinical Cancer Research 3, no. 12 I (1997): 2253-2261.
  - Hare, CB, Elion, GB, Colvin, OM, Ali-Osman, F, Griffith, OW, Petros, WP, Keir, S, Marcelli, SL, Bigner, DD, and Friedman, HS. "Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft." Cancer Chemother Pharmacol 40, no. 5 (1997): 409-414. Full Text Link to Item
  - Ali-Osman, F, Antoun, G, Wang, H, Rajagopal, S, and Gagucas, E. "Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells." Mol Pharmacol 49, no. 6 (June 1996): 1012-1020. Link to Item
  - Srivenugopal, KS, and Ali-Osman, F. "Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells." Oncogene 12, no. 9 (May 2, 1996): 2029-2034. Link to Item
  - Srivenugopal, KS, Yuan, XH, Friedman, HS, and Ali-Osman, F. "Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea." Biochemistry 35, no. 4 (January 30, 1996): 1328-1334. Full Text Link to Item
  - Ali-Osman, F. "Culture of human normal brain and malignant brain tumors for cellular, molecular, and pharmacological studies." Methods Mol Med 2 (1996): 63-80. Full Text Link to Item
  - Dong, Q, Bullock, N, Ali-Osman, F, Colvin, OM, Bigner, DD, and Friedman, HS. "Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines." Cancer Chemother Pharmacol 37, no. 3 (1996): 242-246. Link to Item
  - Moynihan, K, Elion, GB, Ali-Osman, F, Marcelli, S, Keir, S, Bigner, DD, and Friedman, HS. "Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta." Cancer Chemother Pharmacol 38, no. 4 (1996): 349-354. Link to Item
  - Wei, Q, Xu, X, Cheng, L, Legerski, RJ, and Ali-Osman, F. "Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR." Cancer research 55, no. 21 (November 1995): 5025-5029.
  - Spence, AM, Rasey, JS, Dwyer-Hansen, L, Grunbaum, Z, Livesey, J, Chin, L, Nelson, N, Stein, D, Krohn, KA, and Ali-Osman, F. "Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates." Radiother Oncol 35, no. 3 (June 1995): 216-226. Link to Item
  - Li, L, Yoo, H, Becker, FF, Ali-Osman, F, and Chan, JY. "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid." Biochem Biophys Res Commun 206, no. 2 (January 17, 1995): 764-774. Link to Item
  - Aggarwal, BB, Pocsik, E, Totpal, K, and Ali-Osman, F. "Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene." FEBS Lett 357, no. 1 (January 2, 1995): 1-6. Link to Item
  - Ali-Osman, F, Rairkar, A, and Young, P. "Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells." Cancer Biochem Biophys 14, no. 4 (January 1995): 231-241. Link to Item
  - Aggarwal, BB, Pocsik, E, Ali-Osman, F, and Totpal, K. "Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor." FEBS Lett 354, no. 1 (October 31, 1994): 12-16. Link to Item
  - Buzaid, AC, Grimm, EA, Ali-Osman, F, Ring, S, Eton, O, Papadopoulos, NE, Bedikian, A, Plager, C, Legha, SS, and Benjamin, R. "Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results." Melanoma Res 4, no. 5 (October 1994): 327-330. Link to Item
  - Yoshida, M, Khokhar, AR, Kido, Y, Ali-Osman, F, and Siddik, ZH. "Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin." Biochem Pharmacol 48, no. 4 (August 17, 1994): 793-799. Link to Item
  - Friedman, HS, Dolan, ME, Kaufmann, SH, Colvin, OM, Griffith, OW, Moschel, RC, Schold, SC, Bigner, DD, and Ali-Osman, F. "Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan." Cancer Res 54, no. 13 (July 1, 1994): 3487-3493. Link to Item
  - Aggarwal, BB, Totpal, K, Ali-Osman, F, Budde, RJ, and Pocsik, E. "pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor." FEBS Lett 345, no. 2-3 (May 30, 1994): 219-224. Link to Item
  - Pocsik, E, Mihalik, R, Ali-Osman, F, and Aggarwal, BB. "Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response." J Cell Biochem 54, no. 4 (April 1994): 453-464. Full Text Link to Item
  - Sawaya, R, Tofilon, PJ, Mohanam, S, Ali-Osman, F, Liotta, LA, Stetler-Stevenson, WG, and Rao, JS. "Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes." Int J Cancer 56, no. 2 (January 15, 1994): 214-218. Link to Item
  - Ali-Osman, F, Berger, MS, Rairkar, A, and Stein, DE. "Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy." J Cell Biochem 54, no. 1 (January 1994): 11-19. Full Text Link to Item
  - Rao, JS, Steck, PA, Tofilon, P, Boyd, D, Ali-Osman, F, Stetler-Stevenson, WG, Liotta, LA, and Sawaya, R. "Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model." J Neurooncol 18, no. 2 (1994): 129-138. (Review) Link to Item
  - Ali-Osman, F, Berger, MS, Rajagopal, S, Spence, A, and Livingston, RB. "Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells." Cancer Res 53, no. 23 (December 1, 1993): 5663-5668. Link to Item
  - Ishikawa, T, and Ali-Osman, F. "Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance." J Biol Chem 268, no. 27 (September 25, 1993): 20116-20125. Link to Item
  - Mohanam, S, Sawaya, R, McCutcheon, I, Ali-Osman, F, Boyd, D, and Rao, JS. "Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody." Cancer Res 53, no. 18 (September 15, 1993): 4143-4147. Link to Item
  - Sriram, R, and Ali-Osman, F. "Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line." Biochem Mol Biol Int 30, no. 6 (August 1993): 1053-1060. Link to Item
  - Silbergeld, DL, Mayberg, MR, Berger, MS, Ali-Osman, F, Kelly, WA, and Shaw, CM. "Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations." J Neurooncol 16, no. 1 (April 1993): 39-46. Link to Item
  - Genka, S, Deutsch, J, Shetty, UH, Stahle, PL, John, V, Lieberburg, IM, Ali-Osman, F, Rapoport, SI, and Greig, NH. "Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil." Clin Exp Metastasis 11, no. 2 (March 1993): 131-140. Link to Item
  - Spence, AM, Berger, MS, Livingston, RB, Ali-Osman, F, and Griffin, B. "Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure." J Neurooncol 12, no. 2 (February 1992): 187-191. Link to Item
  - Silbergeld, DL, Ali-Osman, F, and Winn, HR. "Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells." J Neurosurg 75, no. 4 (October 1991): 604-612. Full Text Link to Item
  - Silbergeld, DL, and Ali-Osman, F. "Isolation and characterization of microvessels from normal brain and brain tumors." J Neurooncol 11, no. 1 (August 1991): 49-55. Link to Item
  - Ali-Osman, F, Stein, DE, and Renwick, A. "Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines." Cancer Res 50, no. 21 (November 1, 1990): 6976-6980. Link to Item
  - Ali-Osman, F, and Schofield, D. "Cellular and molecular studies in brain and nervous system oncology." Curr Opin Oncol 2, no. 4 (August 1990): 655-665. (Review) Link to Item
  - Srivenugopal, KS, and Ali-Osman, F. "Stimulation and inhibition of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced strand breaks and interstrand cross-linking in Col E1 plasmid deoxyribonucleic acid by polyamines and inorganic cations." Biochem Pharmacol 40, no. 3 (August 1, 1990): 473-479. Link to Item
  - Sriram, R, and Ali-Osman, F. "S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells." Anal Biochem 187, no. 2 (June 1990): 345-348. Link to Item
  - Ali-Osman, F, Srivenugopal, K, Berger, MS, and Stein, DE. "DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance." Anticancer Res 10, no. 3 (May 1990): 677-682. Link to Item
  - Canady, KS, Ali-Osman, F, and Rubel, EW. "Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells." Glia 3, no. 5 (1990): 368-374. Full Text Link to Item
  - Ali-Osman, F, Caughlan, J, and Gray, GS. "Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione." Cancer Res 49, no. 21 (November 1, 1989): 5954-5958. Link to Item
  - Ali-Osman, F. "Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione." Cancer Res 49, no. 19 (October 1, 1989): 5258-5261. Link to Item
  - Ali-Osman, F, and Beltz, PA. "Optimization and characterization of the capillary human tumor clonogenic cell assay." Cancer Res 48, no. 3 (February 1, 1988): 715-724. Link to Item
  - Ali-Osman, F, Giblin, J, Dougherty, D, and Rosenblum, ML. "Application of in vivo and in vitro pharmacokinetics for physiologically relevant drug exposure in a human tumor clonogenic cell assay." Cancer Res 47, no. 14 (July 15, 1987): 3718-3724. Link to Item
  - Moezzi, J, Ali-Osman, F, and Murphy, MJ. "Rapid method for permanent slide preparation of colonies in soft agar cultures." Int J Cell Cloning 4, no. 5 (September 1986): 368-374. Full Text Link to Item
  - Moezzi, J, Ali-Osman, F, Nicholson, GL, Ungerleider, JS, and Murphy, MJ. "Relationship between histopathology and in vitro clonogenicity in breast cancer." Breast Cancer Res Treat 8, no. 2 (1986): 147-156. Link to Item
  - Hübner, GE, Ali-Osman, F, Kastner, M, Papadimitriou, C, and Maurer, HR. "Reculturing of cells from primary CFU-C colonies." Z Naturforsch C 40, no. 11-12 (November 1985): 891-897. Link to Item
  - Ali-Osman, F, Giblin, J, Berger, M, Murphy, MJ, and Rosenblum, ML. "Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas." Cancer Res 45, no. 9 (September 1985): 4185-4191. Link to Item
  - Ali-Osman, F, Rosenblum, ML, Giannini, DD, and Levin, VA. "Potential antiglioma activity of 9-hydroxy-2-N-methylellipticine as determined by pharmacological and human tumor clonogenic cell studies." Cancer Res 45, no. 7 (July 1985): 2988-2992. Link to Item
  - Berger, MS, Talcott, RE, Rosenblum, ML, Silva, M, AliOsman, F, and Smith, MT. "Use of quinones in brain-tumor therapy: Preliminary results of preclinical laboratory investigations." Journal of Toxicology and Environmental Health 16, no. 5 (1985): 713-719.
  - Dittmar, W, Klitschka, G, Braun, R, Ali-Osman, F, Meckert, C, and Maurer, HR. "In vitro and in vivo investigations for the development of cytostatic methylhydrazones." J Cancer Res Clin Oncol 110, no. 2 (1985): 110-114. Link to Item
  - Maurer, HR, Meckert, C, Ali-Osman, F, and Musil, J. "Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU)." Arzneimittelforschung 34, no. 9 (1984): 939-943. Link to Item
  - Ali-Osman, F, and Maurer, HR. "Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity." J Cancer Res Clin Oncol 106, no. 1 (1983): 17-20. Link to Item
  - Osman, FA, Bier, J, Bier, H, Siegel, T, Maurer, HR, and Ohanian, S. "Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity." International Journal of Cell Cloning 1, no. 2 (1983): 118-127.
  - Neumeier, R, Ali-Osman, F, and Maurer, HR. "Two different types of granulocyte colony-stimulating factor produced by bovine lung tissue." Blut 44, no. 1 (January 1982): 21-27. Link to Item
  - Maurer, HR, and Ali-Osman, F. "Tumor stem cell cloning in agar-containing capillaries." Naturwissenschaften 68, no. 7 (July 1981): 381-383. Link to Item
  - Ali-Osman, F, and Maurer, HR. "Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays." J Cancer Res Clin Oncol 98, no. 3 (1980): 221-231. Link to Item
- Other Articles
  - Augustine, CK, Yoo, JS, Potti, A, Yoshimoto, Y, Zipfel, PA, Friedman, HS, Nevins, JR, Ali-Osman, F, and Tyler, DS. "Correction: Article on genomic and molecular profiling to predict response to temozolomide (Clinical Cancer Research (2009) 15, (502-510))." Clinical Cancer Research 15, no. 9 (2009): 3240--. Full Text

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