Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • D.Sc., Free University of Berlin (Germany) 1982
• 

  Duke Appointment History

  • Professor in Pathology, Pathology, Clinical Science Departments 2004 - 2018
  • Professor in Neurosurgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2017 - 2018
  • Professor of Surgery, Surgery, Surgical Sciences, Surgery 2004 - 2017
  • Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2003
• Expertise
• 

  Global Scholarship

  • Research

    • Ghana (Country) 
• Research
• 

  Selected Grants

  • Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
  • Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
  • P53-dependent GSTP1 Gene Regulation and Glioma Drug Resistance awarded by National Institutes of Health 2010 - 2015
  • Protein Kinase C and GSTP1 interactions in glioma drug resistance awarded by National Institutes of Health 2008 - 2014
  • Nuclear EGFR Signaling Network in Human Cancer awarded by National Institutes of Health 2006 - 2012
  • Novel Targeted Therapeutics for CNS Malignancies awarded by National Institutes of Health 2006 - 2011
  • Radionuclide-based Molecular Imaging of the DNA Repair Protein AGT awarded by National Institutes of Health 2009 - 2011
  • Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
  • DNA Methylation and GSTP1 Gene Regulation in Gliomas awarded by National Institutes of Health 2002 - 2008
  • Planning a Duke Academic Public Private Partnership Program (AP4) Center awarded by National Cancer Institute 2004 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Sjöberg, Rickard L., Wendy Yi-Ying Wu, Anna M. Dahlin, Spiridon Tsavachidis, Spiridon Gliogene Group, Melissa L. Bondy, and Beatrice Melin. “Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study.” J Neurooncol 145, no. 2 (November 2019): 287–94. https://doi.org/10.1007/s11060-019-03294-w.
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    • Amirian, E Susan, Quinn T. Ostrom, Georgina N. Armstrong, Rose K. Lai, Xiangjun Gu, Daniel I. Jacobs, Ali Jalali, et al. “Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis.” Cancer Epidemiol Biomarkers Prev 28, no. 3 (March 2019): 555–62. https://doi.org/10.1158/1055-9965.EPI-18-0702.
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    • Madala, Hanumantha Rao, Surendra R. Punganuru, Francis Ali-Osman, Ruiwen Zhang, and Kalkunte S. Srivenugopal. “Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts.” Oncotarget 9, no. 3 (January 9, 2018): 3459–82. https://doi.org/10.18632/oncotarget.23320.
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    • Erdal, Serap, Bridget J. McCarthy, Natalia Gurule, Marianne Berwick, Emily Gonzales, Johanna Byrd, Kristina Flores, et al. “Application of mutagen sensitivity assay in a glioma case-control study.” Toxicol Rep 5 (2018): 183–88. https://doi.org/10.1016/j.toxrep.2017.12.010.
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    • Melin, Beatrice S., Jill S. Barnholtz-Sloan, Margaret R. Wrensch, Christoffer Johansen, Dora Il’yasova, Ben Kinnersley, Quinn T. Ostrom, et al. “Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.” Nat Genet 49, no. 5 (May 2017): 789–94. https://doi.org/10.1038/ng.3823.
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    • Paranjpe, Ameya, Nathan I. Bailey, Santhi Konduri, George C. Bobustuc, Francis Ali-Osman, Mohd A. Yusuf, Surendra R. Punganuru, et al. “New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy.” J Biomed Res 30, no. 5 (September 2016): 393–410. https://doi.org/10.7555/JBR.30.20160040.
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    • Amirian, E Susan, Michael E. Scheurer, Renke Zhou, Margaret R. Wrensch, Georgina N. Armstrong, Daniel Lachance, Sara H. Olson, et al. “History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC).” Cancer Med 5, no. 6 (June 2016): 1352–58. https://doi.org/10.1002/cam4.682.
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    • Amirian, E Susan, Renke Zhou, Margaret R. Wrensch, Sara H. Olson, Michael E. Scheurer, Dora Il’yasova, Daniel Lachance, et al. “Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study.” Cancer Epidemiol Biomarkers Prev 25, no. 2 (February 2016): 282–90. https://doi.org/10.1158/1055-9965.EPI-15-0847.
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    • Amirian, E Susan, Georgina N. Armstrong, Renke Zhou, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Dora Il’yasova, et al. “The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.” Am J Epidemiol 183, no. 2 (January 15, 2016): 85–91. https://doi.org/10.1093/aje/kwv235.
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    • Okamura, Tatsunori, Gamil Antoun, Stephen T. Keir, Henry Friedman, Darell D. Bigner, and Francis Ali-Osman. “Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.” J Biol Chem 290, no. 52 (December 25, 2015): 30866–78. https://doi.org/10.1074/jbc.M115.656140.
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    • Brown, Kristine E., Gustavo Chagoya, Shawn G. Kwatra, Timothy Yen, Stephen T. Keir, Mary Cooter, Katherine A. Hoadley, et al. “Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development.” J Neurochem 133, no. 5 (June 2015): 730–38. https://doi.org/10.1111/jnc.13032.
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    • Jalali, Ali, E Susan Amirian, Matthew N. Bainbridge, Georgina N. Armstrong, Yanhong Liu, Spyros Tsavachidis, Shalini N. Jhangiani, et al. “Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.” Sci Rep 5 (February 5, 2015): 8278. https://doi.org/10.1038/srep08278.
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    • Bainbridge, Matthew N., Georgina N. Armstrong, M Monica Gramatges, Alison A. Bertuch, Shalini N. Jhangiani, Harsha Doddapaneni, Lora Lewis, et al. “Germline mutations in shelterin complex genes are associated with familial glioma.” J Natl Cancer Inst 107, no. 1 (January 2015): 384. https://doi.org/10.1093/jnci/dju384.
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    • Lidsky, Michael, Gamil Antoun, Paul Speicher, Bartley Adams, Ryan Turley, Christi Augustine, Douglas Tyler, and Francis Ali-Osman. “Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells.” J Biol Chem 289, no. 40 (October 3, 2014): 27714–26. https://doi.org/10.1074/jbc.M113.532432.
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    • Paranjpe, Ameya, Ruiwen Zhang, Francis Ali-Osman, George C. Bobustuc, and Kalkunte S. Srivenugopal. “Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.” Carcinogenesis 35, no. 3 (March 2014): 692–702. https://doi.org/10.1093/carcin/bgt366.
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    • Kinev, Alexander V., Vrad Levering, Kenneth Young, Francis Ali-Osman, George A. Truskey, Mark W. Dewhirst, and Dora Il’yasova. “Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose.” Cancer Invest 31, no. 5 (June 2013): 359–64. https://doi.org/10.3109/07357907.2013.789903.
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    • “Correction.” Cancer Science 104, no. 2 (February 2013): 274–274. https://doi.org/10.1111/cas.12109.
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    • Yang, Wei, Liangli Wang, Gabriele Roehn, Robert D. Pearlstein, Francis Ali-Osman, Hongjie Pan, Roland Goldbrunner, Matthew Krantz, Christoph Harms, and Wulf Paschen. “Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.” Cancer Sci 104, no. 1 (January 2013): 70–77. https://doi.org/10.1111/cas.12047.
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    • Okamura, Tatsunori, and Francis Ali-Osman. “Abstract 2162: EGFR-induced interaction of GSTP1 with the SH2-domain of Grb2 enhances Ras downstream activation in human glioma cells.” Molecular and Cellular Biology, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-2162.
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    • Turley, Ryan S., Michael E. Lidsky, Douglas S. Tyler, and Francis Ali-Osman. “Abstract 2012: MAP kinase activation and suppression of anti-apoptotic Bcl-2 family members are associated with induction of apoptotic death in melanoma cells following down-regulation of glutathione S-transferase P1.” Molecular and Cellular Biology, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-2012.
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    • Lachance, Daniel H., Ping Yang, Derek R. Johnson, Paul A. Decker, Thomas M. Kollmeyer, Lucie S. McCoy, Terri Rice, et al. “Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.” Am J Epidemiol 174, no. 5 (September 1, 2011): 574–81. https://doi.org/10.1093/aje/kwr124.
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    • Cao, Xinyu, Mark Dewhirst, Francis Ali-Osman, and Hui-Wen Lo. “Abstract 2337: Defining significance of the novel tGLI1 transcription factor in cancer growth and progression.” Tumor Biology, April 15, 2011. https://doi.org/10.1158/1538-7445.am2011-2337.
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    • Okamura, Tatsunori, and Francis Ali-osman. “Abstract 703: GSTP1 inhibition of HSP27 phosphorylation contributes to glioma drug resistance.” Experimental and Molecular Therapeutics, April 15, 2011. https://doi.org/10.1158/1538-7445.am2011-703.
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    • Turley, Ryan S., Jiewu Liu, Douglas Tyler, and Francis Ali-Osman. “Abstract 1635: Short hairpin RNA-mediated transcriptional suppression of glutathione S-transferase P1 suppresses growth and induces apoptosis through altered MAP kinase signaling in melanoma cells.” Experimental and Molecular Therapeutics, April 15, 2011. https://doi.org/10.1158/1538-7445.am2011-1635.
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    • Cao, Xinyu, Hu Zhu, Francis Ali-Osman, and Hui-Wen Lo. “EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis.” Mol Cancer 10 (March 9, 2011): 26. https://doi.org/10.1186/1476-4598-10-26.
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    • McCarthy, Bridget J., Kristin Rankin, Dora Il’yasova, Serap Erdal, Nicholas Vick, Francis Ali-Osman, Darell D. Bigner, and Faith Davis. “Assessment of type of allergy and antihistamine use in the development of glioma.” Cancer Epidemiol Biomarkers Prev 20, no. 2 (February 2011): 370–78. https://doi.org/10.1158/1055-9965.EPI-10-0948.
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    • Advani, Anjali S., Mazyar Shadman, Francis Ali-Osman, Andrew Barker, Lisa Rybicki, Matt Kalaycio, Mikkael A. Sekeres, et al. “A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse.” Clin Lymphoma Myeloma Leuk 10, no. 6 (December 2010): 473–76. https://doi.org/10.3816/CLML.2010.n.082.
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    • Jones, Lee W., Francis Ali-Osman, Eric Lipp, Jennifer E. Marcello, Bridget McCarthy, Lucie McCoy, Terri Rice, Margaret Wrensch, and Dora Il’yasova. “Association between body mass index and mortality in patients with glioblastoma mutliforme.” Cancer Causes Control 21, no. 12 (December 2010): 2195–2201. https://doi.org/10.1007/s10552-010-9639-x.
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    • Cui, Bo, Stewart P. Johnson, Nancy Bullock, Francis Ali-Osman, Darell D. Bigner, and Henry S. Friedman. “Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells.” J Biomed Res 24, no. 6 (November 2010): 424–35. https://doi.org/10.1016/S1674-8301(10)60057-7.
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    • Singh, Simendra, Tatsunori Okamura, and Francis Ali-Osman. “Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.” Biochem Pharmacol 80, no. 9 (November 1, 2010): 1343–55. https://doi.org/10.1016/j.bcp.2010.07.019.
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    • Toshimitsu, Hiroaki, Yasunori Yoshimoto, Christina K. Augustine, James C. Padussis, Jin S. Yoo, M. Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.” Ann Surg Oncol 17, no. 8 (August 2010): 2247–54. https://doi.org/10.1245/s10434-010-0971-x.
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    • Zhu, Hu, Xinyu Cao, Francis Ali-Osman, Stephen Keir, and Hui-Wen Lo. “EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.” Cancer Lett 294, no. 1 (August 1, 2010): 101–10. https://doi.org/10.1016/j.canlet.2010.01.028.
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    • Augustine, Christina K., Hiroaki Toshimitsu, Sin-Ho Jung, Patricia A. Zipfel, Jin S. Yoo, Yasunori Yoshimoto, M Angelica Selim, et al. “Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.” Mol Cancer Ther 9, no. 7 (July 2010): 2090–2101. https://doi.org/10.1158/1535-7163.MCT-10-0073.
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    • Crout, Christopher A., Liang-Piu Koh, Jon P. Gockerman, Joseph O. Moore, Carlos Decastro, Gwynn D. Long, Louis Diehl, et al. “Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy.” Cancer Invest 28, no. 6 (July 2010): 654–60. https://doi.org/10.3109/07357901003631015.
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    • Augustine, Christina K., Sin-Ho Jung, Insuk Sohn, Jin Soo Yoo, Yasunori Yoshimoto, John A. Olson, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.” Mol Cancer Ther 9, no. 4 (April 2010): 779–90. https://doi.org/10.1158/1535-7163.MCT-09-0764.
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    • Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes.” Mol Cancer Res 8, no. 2 (February 2010): 232–45. https://doi.org/10.1158/1541-7786.MCR-09-0391.
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    • Lo, Hui-Wen, Hu Zhu, Xinyu Cao, Amy Aldrich, and Francis Ali-Osman. “A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.” Cancer Res 69, no. 17 (September 1, 2009): 6790–98. https://doi.org/10.1158/0008-5472.CAN-09-0886.
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    • Okamura, Tatsunori, Simendra Singh, John Buolamwini, Timothy Haystead, Henry Friedman, Darell Bigner, and Francis Ali-Osman. “Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.” J Biol Chem 284, no. 25 (June 19, 2009): 16979–89. https://doi.org/10.1074/jbc.M808153200.
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    • Cui, B., S. P. Johnson, N. Bullock, F. Ali-Osman, D. D. Bigner, and H. S. Friedman. “Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.” Mol Pharmacol 75, no. 6 (June 2009): 1356–63. https://doi.org/10.1124/mol.108.053124.
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    • Antoun, Gamil, and Francis Ali-Osman. “Structural and functional analysis of Nucleophosmin I (NPM1) in human malignant gliomas.” Cancer Research 69 (May 1, 2009).
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    • Okamura, Tatsunori, and Francis Ali-Osman. “Phosphorylation of a C-terminal tyrosine of GSTP1 by EGFR dissociates GSTP1 from the GSTP1-JNK complex leading to JNK activation in glioblastoma cells.” Cancer Research 69 (May 1, 2009).
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    • Singh, Simendra, and Francis Ali-Osman. “Serine-phosphorylation of the GSTP1 protein by PKC\#945; increase GSTP1-mediated cisplatin metabolism and descrease cisplatin-induced DNA interstrand cross link formation and cisplatin sensitivity in human glioma cells.” Cancer Research 69 (May 1, 2009).
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    • Zhu, Hu, Xinyu Cao, Amy Aldrich, Francis Ali-Osman, and Hui-Wen Lo. “EGFR and EGFRvIII attenuate drug-induced apoptosis in glioblastomas via mitochondrial transport and interaction with pro-apoptotic proteins:A novel EGFR/EGFRvIII-mediated mechanism in drug resistance.” Cancer Research 69 (May 1, 2009).
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    • Il’yasova, Dora, Bridget McCarthy, Jennifer Marcello, Joellen M. Schildkraut, Patricia G. Moorman, Bhuma Krishnamachari, Francis Ali-Osman, Darell D. Bigner, and Faith Davis. “Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls.” Cancer Epidemiol Biomarkers Prev 18, no. 4 (April 2009): 1232–38. https://doi.org/10.1158/1055-9965.EPI-08-0995.
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    • Okamura, Tatsunori, Simendrah Singh, John K. Buolamwini, Henry S. Friedman, Darell D. Bigner, and Francis Ali-Osman. “EGF RECEPTOR TYROSINE KINASE MEDIATES A NOVEL PATHWAY OF DRUG RESISTANCE IN MALIGNANT GLIOMAS VIA TYROSINE PHOSPHORYLATION AND FUNCTIONAL ACTIVATION OF GLUTATHIONE S-TRANSFERASE P1.” Neuro Oncology 11, no. 2 (April 1, 2009): 218–218.
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    • Augustine, Christina K., Jin Soo Yoo, Anil Potti, Yasunori Yoshimoto, Patricia A. Zipfel, Henry S. Friedman, Joseph R. Nevins, Francis Ali-Osman, and Douglas S. Tyler. “Genomic and molecular profiling predicts response to temozolomide in melanoma.” Clin Cancer Res 15, no. 2 (January 15, 2009): 502–10. https://doi.org/10.1158/1078-0432.CCR-08-1916.
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    • Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators.” Clin Cancer Res 14, no. 19 (October 1, 2008): 6042–54. https://doi.org/10.1158/1078-0432.CCR-07-4923.
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    • Maxwell, Jill A., Stewart P. Johnson, Roger E. McLendon, David W. Lister, Krystle S. Horne, Ahmed Rasheed, Jennifer A. Quinn, et al. “Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma.” Clin Cancer Res 14, no. 15 (August 1, 2008): 4859–68. https://doi.org/10.1158/1078-0432.CCR-07-4807.
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    • Xie, Tong-Xin, Kenneth D. Aldape, Weida Gong, Takao Kanzawa, Dima Suki, Seiji Kondo, Frederick Lang, Francis Ali-Osman, Raymond Sawaya, and Suyun Huang. “Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor.” Int J Oncol 33, no. 1 (July 2008): 5–15.
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    • Augustine, C. K., S. Jung, A. Potti, I. Sohn, J. S. Yoo, P. Zipfel, J. Olson, F. Ali-Osman, J. R. Nevins, and D. S. Tyler. “Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 9077.
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    • Augustine, C. K., S. Jung, A. Potti, I. Sohn, J. S. Yoo, P. Zipfel, Olson J. Jr, F. Ali-Osman, J. R. Nevins, and D. S. Tyler. “Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.” Journal of Clinical Oncology 26, no. 15 (May 20, 2008). https://doi.org/10.1200/jco.2008.26.15_suppl.9077.
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    • Lo, Hui-Wen, Lisa Stephenson, Xinyu Cao, Mira Milas, Raphael Pollock, and Francis Ali-Osman. “Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.” Mol Cancer Res 6, no. 5 (May 2008): 843–50. https://doi.org/10.1158/1541-7786.MCR-07-2105.
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    • Lo, Hui-Wen, and Francis Ali-Osman. “Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.” Curr Opin Pharmacol 7, no. 4 (August 2007): 367–74. https://doi.org/10.1016/j.coph.2007.06.009.
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    • Tew, Kenneth D. “Redox pathways in cancer drug discovery.” Curr Opin Pharmacol 7, no. 4 (August 2007): 353–54. https://doi.org/10.1016/j.coph.2007.07.003.
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    • Yoshimoto, Yasunori, Christina K. Augustine, Jin S. Yoo, Patricia A. Zipfel, M Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.” Mol Cancer Ther 6, no. 5 (May 2007): 1492–1500. https://doi.org/10.1158/1535-7163.MCT-06-0718.
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    • Maxwell, Jill A., Stewart P. Johnson, Jennifer A. Quinn, Roger E. McLendon, Francis Ali-Osman, Allan H. Friedman, James E. Herndon, et al. “Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma.” Mol Cancer Ther 5, no. 10 (October 2006): 2531–39. https://doi.org/10.1158/1535-7163.MCT-06-0106.
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    • Cheng, C Lynn, Stewart P. Johnson, Stephen T. Keir, Jennifer A. Quinn, Francis Ali-Osman, Csaba Szabo, Hongshan Li, et al. “Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.” Mol Cancer Ther 4, no. 9 (September 2005): 1364–68. https://doi.org/10.1158/1535-7163.MCT-05-0128.
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    • Shou, J., K. S. Srivenugopal, S. R. S. Mullapudi, F. F. Lang, J. S. Rao, and F. Ali-Osman. “Erratum: Enforced expression of wild-type p53 curtails the transcription of the O⁶-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents (Clinical Cancer Research (May 1, 2001) 7 (1398-1409)).” Clinical Cancer Research 11, no. 6 (March 15, 2005). https://doi.org/10.1158/1078-0432.CCR-11-6-COR.
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    • Shou, J., K. S. Srivenugopal, S. R. S. Mullapudi, F. F. Lang, J. S. Rao, and F. Ali-Osman. “Article on the enforced expression of wild-type p53 and the transcription of the O-6 -methylguanine-DNA methyltransferase gene (vol 7, pg 1398, 2001).” Clinical Cancer Research 11, no. 6 (March 15, 2005): 2449–2449.
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    • Lo, Hui-Wen, Gamil R. Antoun, and Francis Ali-Osman. “The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.” Cancer Res 64, no. 24 (December 15, 2004): 9131–38. https://doi.org/10.1158/0008-5472.CAN-04-0283.
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    • Xie, Tong-Xin, Daoyan Wei, Mingguang Liu, Allen C. Gao, Francis Ali-Osman, Raymond Sawaya, and Suyun Huang. “Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis.” Oncogene 23, no. 20 (April 29, 2004): 3550–60. https://doi.org/10.1038/sj.onc.1207383.
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    • Okcu, M Fatih, Mano Selvan, Li-E Wang, Linda Stout, Rodrigo Erana, Gladstone Airewele, Phyllis Adatto, et al. “Glutathione S-transferase polymorphisms and survival in primary malignant glioma.” Clin Cancer Res 10, no. 8 (April 15, 2004): 2618–25. https://doi.org/10.1158/1078-0432.ccr-03-0053.
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    • Barnette, Phillip, Rebecca Scholl, Mary Blandford, Linda Ballard, Alexander Tsodikov, Jalene Magee, Susana Williams, et al. “High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population.” Cancer Epidemiol Biomarkers Prev 13, no. 2 (February 2004): 304–13. https://doi.org/10.1158/1055-9965.epi-03-0178.
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    • Konduri, Santhi D., Kalkunte S. Srivenugopal, Niranjan Yanamandra, Dzung H. Dinh, William C. Olivero, Meena Gujrati, Donald C. Foster, et al. “Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.” Oncogene 22, no. 29 (July 17, 2003): 4509–16. https://doi.org/10.1038/sj.onc.1206695.
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    • Wang, Yunfei, Margaret R. Spitz, Matthew B. Schabath, Francis Ali-Osman, Hilario Mata, and Xifeng Wu. “Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study.” Lung Cancer 40, no. 1 (April 2003): 25–32. https://doi.org/10.1016/s0169-5002(02)00537-8.
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    • Zheng, T., T. R. Holford, S. H. Zahm, P. H. Owens, P. Boyle, Y. Zhang, B. Zhang, J. P. Wise, L. P. Stephenson, and F. Ali-Osman. “Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk.” Br J Cancer 88, no. 1 (January 13, 2003): 58–62. https://doi.org/10.1038/sj.bjc.6600708.
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    • Ishimoto, Tricia M., and Francis Ali-Osman. “Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli.” Pharmacogenetics 12, no. 7 (October 2002): 543–53. https://doi.org/10.1097/00008571-200210000-00006.
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    • Zheng, Tongzhang, Theodore R. Holford, Shelia H. Zahm, Patricia H. Owens, Peter Boyle, Yawei Zhang, John Pierce Wise, Lisa Pleasants Stephenson, and Francis Ali-Osman. “Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States).” Cancer Causes Control 13, no. 7 (September 2002): 637–45. https://doi.org/10.1023/a:1019500109267.
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    • Srivenugopal, Kalkunte S., and Francis Ali-Osman. “The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.” Oncogene 21, no. 38 (August 29, 2002): 5940–45. https://doi.org/10.1038/sj.onc.1205762.
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    • Srivenugopal, Kalkunte S., Srinivas R. S. Mullapudi, and Francis Ali-Osman. “Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay.” Cancer Lett 181, no. 1 (July 8, 2002): 87–93. https://doi.org/10.1016/s0304-3835(01)00823-0.
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    • Bacolod, Manny D., Stewart P. Johnson, Francis Ali-Osman, Paul Modrich, Nancy S. Bullock, O Michael Colvin, Darell D. Bigner, and Henry S. Friedman. “Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.” Mol Cancer Ther 1, no. 9 (July 2002): 727–36.
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    • Madden, R. M., K. W. Chan, L. P. Stephenson, and F. Ali-Osman. “Analysis and significance of the genetic polymorphism of the glutathione S-transferase P1 gene locus in pediatric tumors.” Pediatric Research 51, no. 4 (April 2002): 233A-233A.
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    • Konduri, Santhi D., Francis Ali Osman, Chilukuri N. Rao, Harish Srinivas, Niranjan Yanamandra, Anastasia Tasiou, Dzung H. Dinh, et al. “Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.” Oncogene 21, no. 6 (January 31, 2002): 921–28. https://doi.org/10.1038/sj.onc.1204983.
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    • Shou, Jiang, Francis Ali-Osman, Asha S. Multani, Sen Pathak, Paolo Fedi, and Kalkunte S. Srivenugopal. “Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.” Oncogene 21, no. 6 (January 31, 2002): 878–89. https://doi.org/10.1038/sj.onc.1205138.
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    • Lo, Hui-Wen, and Francis Ali-Osman. “Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.” J Cell Biochem 87, no. 1 (2002): 103–16. https://doi.org/10.1002/jcb.10275.
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    • Mohanam, S., S. L. Jasti, S. R. Kondraganti, N. Chandrasekar, S. S. Lakka, Y. Kin, G. N. Fuller, et al. “Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.” Oncogene 20, no. 28 (June 21, 2001): 3665–73. https://doi.org/10.1038/sj.onc.1204480.
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    • Srivenugopal, K. S., J. Shou, S. R. Mullapudi, F. F. Lang, J. S. Rao, and F. Ali-Osman. “Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents.” Clin Cancer Res 7, no. 5 (May 2001): 1398–1409.
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    • Lakka, S. S., R. Rajagopal, M. K. Rajan, P. M. Mohan, Y. Adachi, D. H. Dinh, W. C. Olivero, et al. “Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines.” Clin Cancer Res 7, no. 4 (April 2001): 1087–93.
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    • Ali-Osman, F., K. Srivenugopal, and R. Sawaya. “The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.” N Engl J Med 344, no. 9 (March 1, 2001): 687.
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    • Buckner, J. C., and T. J. Moynihan. “The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.” N Engl J Med 344, no. 9 (March 1, 2001): 686.
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    • Lo, H. W., and F. Ali-Osman. “The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site.” Chemico Biological Interactions 133, no. 1–3 (February 28, 2001): 320–21.
    • Maugard, C. M., J. Charrier, A. Pitard, L. Campion, O. Akande, L. Pleasants, and F. Ali-Osman. “Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier.” Int J Cancer 91, no. 3 (February 1, 2001): 334–39. https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1057>3.0.co;2-h.
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    • Kondraganti, S., S. Mohanam, S. K. Chintala, Y. Kin, S. L. Jasti, C. Nirmala, S. S. Lakka, et al. “Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion.” Cancer Res 60, no. 24 (December 15, 2000): 6851–55.
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    • Nirmala, C., S. L. Jasti, R. Sawaya, A. P. Kyritsis, S. D. Konduri, F. Ali-Osman, J. S. Rao, and S. Mohanam. “Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions.” Int J Cancer 88, no. 5 (December 1, 2000): 766–71. https://doi.org/10.1002/1097-0215(20001201)88:5<766::aid-ijc13>3.0.co;2-y.
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    • Mullapudi, S. R., F. Ali-Osman, J. Shou, and K. S. Srivenugopal. “DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.” Biochem J 351 Pt 2 (October 15, 2000): 393–402.
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    • Ramachandran, S., P. R. Hoban, F. Ichii-Jones, L. Pleasants, F. Ali-Osman, J. T. Lear, A. G. Smith, et al. “Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours.” Pharmacogenetics 10, no. 6 (August 2000): 545–56. https://doi.org/10.1097/00008571-200008000-00008.
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    • Antoun, G., S. B. Baylin, and F. Ali-Osman. “DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.” J Cell Biochem 77, no. 3 (April 2000): 372–81.
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    • Srivenugopal, K. S., S. R. Mullapudi, J. Shou, T. K. Hazra, and F. Ali-Osman. “Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.” Cancer Res 60, no. 2 (January 15, 2000): 282–87.
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    • Chandrasekar, N., S. Jasti, W. K. Alfred-Yung, F. Ali-Osman, D. H. Dinh, W. C. Olivero, M. Gujrati, et al. “Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions.” Clin Exp Metastasis 18, no. 4 (2000): 337–42. https://doi.org/10.1023/a:1010833730407.
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    • Lakka, S. S., S. L. Jasti, A. P. Kyritsis, W. K. Yung, F. Ali-Osman, G. L. Nicolson, and J. S. Rao. “Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.” Clin Exp Metastasis 18, no. 3 (2000): 245–52. https://doi.org/10.1023/a:1006724826083.
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    • Lo, H. W., and F. Ali-Osman. “Differential transactivation of the hGSTP1 promoter by individual direct/everted repeat retinoic acid response elements in intron 5 of the hGSTP1 gene.” Clinical Chemistry and Enzymology Communications 8, no. 4–6 (December 1, 1999): 293–302.
    • Ali-Osman, F., and J. Buolanwini. “Molecular modeling based design of novel anticancer therapeutics that target the active sites of polymorphic GSTP1 proteins.” Clinical Cancer Research 5 (November 1999): 3841S-3841S.
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    • Multani, A. S., M. Ozen, S. Sen, A. K. Mandal, J. E. Price, D. Fan, R. Radinsky, et al. “Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin.” Int J Oncol 15, no. 3 (September 1999): 423–29. https://doi.org/10.3892/ijo.15.3.423.
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    • Chan, J. Y., and F. Ali-Osman. “In vitro repair synthesis of BCNU-induced DNA damage.” Cancer Biochem Biophys 16, no. 3 (October 1998): 273–86.
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    • Ali-Osman, F., K. D. Tew, and R. C. Strange. “Special issue: Glutathione and glutathione-linked enzymes in human cancer and other diseases - Preface.” Chemico Biological Interactions 112 (April 24, 1998): XIII–XIV.
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    • Keller, C., and F. Ali-Osman. “Translational inhibition of messenger RNA of the human pi class glutathione S-transferase by antisense oligodeoxyribonucleotides.” Chem Biol Interact 111–112 (April 24, 1998): 307–23. https://doi.org/10.1016/s0009-2797(97)00168-3.
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    • Lo, H. W., and F. Ali-Osman. “Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line.” Chem Biol Interact 111–112 (April 24, 1998): 91–102. https://doi.org/10.1016/s0009-2797(97)00153-1.
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    • Anderson, C. M., A. C. Buzaid, J. Sussman, J. J. Lee, F. Ali-Osman, P. G. Braunschweiger, C. Plager, et al. “Nitric oxide and neopterin levels and clinical response in stage III melanoma patients receiving concurrent biochemotherapy.” Melanoma Res 8, no. 2 (April 1998): 149–55. https://doi.org/10.1097/00008390-199804000-00008.
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    • Buzaid, A. C., F. Ali-Osman, N. Akande, E. A. Grimm, J. J. Lee, A. Bedikian, O. Eton, et al. “DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma.” Melanoma Res 8, no. 2 (April 1998): 145–48. https://doi.org/10.1097/00008390-199804000-00007.
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    • Ali-Osman, F. “Antisense oligonucleotide downregulation of human glutathione S-transferase-PI gene expression for enhanced efficacy of cancer chemotherapy.” International Journal of Pediatric Hematology/Oncology 5, no. 1 (January 1, 1998): 48–49.
    • Lo, H. W., and F. Ali-Osman. “Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements.” J Biol Chem 272, no. 52 (December 26, 1997): 32743–49. https://doi.org/10.1074/jbc.272.52.32743.
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    • Ali-Osman, F., J. M. Brunner, T. M. Kutluk, and K. Hess. “Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas.” Clin Cancer Res 3, no. 12 Pt 1 (December 1997): 2253–61.
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    • Ali-Osman, F., J. M. Brunner, T. M. Kutluk, and K. Hess. “Prognostic significance of glutathione S-transferase π expression and subcellular localization in human gliomas.” Clinical Cancer Research 3, no. 12 I (December 1, 1997): 2253–61.
    • Ali-Osman, F., J. M. Brunner, T. M. Kutluk, and K. Hess. “Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas.” Clinical Cancer Research 3, no. 12 (December 1997): 2253–61.
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    • Srivenugopal, K. S., and F. Ali-Osman. “Coordinate up-regulation of cyclin-dependent kinase 4 and its inhibitor p16^INK4 in human glioma cells following chloroethylnitrosourea-induced DNA damage.” International Journal of Oncology 11, no. 6 (December 1, 1997): 1251–56.
    • Friedman, H. S., S. P. Johnson, Q. Dong, S. C. Schold, B. K. Rasheed, S. H. Bigner, F. Ali-Osman, et al. “Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.” Cancer Res 57, no. 14 (July 15, 1997): 2933–36.
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    • Srivenugopal, K. S., and F. Ali-Osman. “Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues.” Cancer Lett 117, no. 1 (July 15, 1997): 105–11. https://doi.org/10.1016/s0304-3835(97)00210-3.
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    • Chintala, S. K., F. Ali-Osman, S. Mohanam, A. Rayford, Y. Go, Z. L. Gokaslan, E. Gagercas, et al. “Effect of cisplatin and BCNU on MMP-2 levels in human glioblastoma cell lines in vitro.” Clin Exp Metastasis 15, no. 4 (July 1997): 361–67. https://doi.org/10.1023/a:1018442003163.
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    • Go, Y., S. K. Chintala, A. Rayford, E. Gagercas, F. Ali-Osman, B. Venkaiah, R. Sawaya, Z. Gokaslan, G. L. Nicolson, and J. S. Rao. “Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro.” Clin Exp Metastasis 15, no. 4 (July 1997): 447–52. https://doi.org/10.1023/a:1018462507706.
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    • Ali-Osman, F., O. Akande, G. Antoun, J. X. Mao, and J. Buolamwini. “Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.” J Biol Chem 272, no. 15 (April 11, 1997): 10004–12. https://doi.org/10.1074/jbc.272.15.10004.
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    • Brandt, T. Y., and F. Ali-Osman. “Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells.” Toxicology and Applied Pharmacology 143, no. 1 (March 1997): 22–29. https://doi.org/10.1006/taap.1996.8010.
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    • Hare, C. B., G. B. Elion, O. M. Colvin, F. Ali-Osman, O. W. Griffith, W. P. Petros, S. Keir, S. L. Marcelli, D. D. Bigner, and H. S. Friedman. “Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft.” Cancer Chemother Pharmacol 40, no. 5 (1997): 409–14. https://doi.org/10.1007/s002800050678.
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    • OSMAN, F. A. “Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.” J. Biol. Chem. 272 (1997): 10004–12.
    • Ali-Osman, F., G. Antoun, H. Wang, S. Rajagopal, and E. Gagucas. “Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells.” Mol Pharmacol 49, no. 6 (June 1996): 1012–20.
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    • Srivenugopal, K. S., and F. Ali-Osman. “Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells.” Oncogene 12, no. 9 (May 2, 1996): 2029–34.
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    • Srivenugopal, K. S., X. H. Yuan, H. S. Friedman, and F. Ali-Osman. “Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea.” Biochemistry 35, no. 4 (January 30, 1996): 1328–34. https://doi.org/10.1021/bi9518205.
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    • Ali-Osman, F. “Culture of human normal brain and malignant brain tumors for cellular, molecular, and pharmacological studies.” Methods Mol Med 2 (1996): 63–80. https://doi.org/10.1385/0-89603-335-X:63.
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    • Dong, Q., N. Bullock, F. Ali-Osman, O. M. Colvin, D. D. Bigner, and H. S. Friedman. “Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.” Cancer Chemother Pharmacol 37, no. 3 (1996): 242–46. https://doi.org/10.1007/BF00688323.
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    • Moynihan, K., G. B. Elion, F. Ali-Osman, S. Marcelli, S. Keir, D. D. Bigner, and H. S. Friedman. “Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.” Cancer Chemother Pharmacol 38, no. 4 (1996): 349–54. https://doi.org/10.1007/s002800050494.
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    • Wei, Q., X. Xu, L. Cheng, R. J. Legerski, and F. Ali-Osman. “Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR.” Cancer Res 55, no. 21 (November 1, 1995): 5025–29.
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    • Spence, A. M., J. S. Rasey, L. Dwyer-Hansen, Z. Grunbaum, J. Livesey, L. Chin, N. Nelson, D. Stein, K. A. Krohn, and F. Ali-Osman. “Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates.” Radiother Oncol 35, no. 3 (June 1995): 216–26. https://doi.org/10.1016/0167-8140(95)01543-p.
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    • Li, L., H. Yoo, F. F. Becker, F. Ali-Osman, and J. Y. Chan. “Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid.” Biochem Biophys Res Commun 206, no. 2 (January 17, 1995): 764–74. https://doi.org/10.1006/bbrc.1995.1108.
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    • Aggarwal, B. B., E. Pocsik, K. Totpal, and F. Ali-Osman. “Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.” Febs Lett 357, no. 1 (January 2, 1995): 1–6. https://doi.org/10.1016/0014-5793(94)01299-g.
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    • Ali-Osman, F., A. Rairkar, and P. Young. “Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells.” Cancer Biochem Biophys 14, no. 4 (January 1995): 231–41.
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    • Aggarwal, B. B., E. Pocsik, F. Ali-Osman, and K. Totpal. “Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.” Febs Lett 354, no. 1 (October 31, 1994): 12–16. https://doi.org/10.1016/0014-5793(94)01073-0.
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    • Buzaid, A. C., E. A. Grimm, F. Ali-Osman, S. Ring, O. Eton, N. E. Papadopoulos, A. Bedikian, C. Plager, S. S. Legha, and R. Benjamin. “Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results.” Melanoma Res 4, no. 5 (October 1994): 327–30. https://doi.org/10.1097/00008390-199410000-00010.
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    • Yoshida, M., A. R. Khokhar, Y. Kido, F. Ali-Osman, and Z. H. Siddik. “Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin.” Biochem Pharmacol 48, no. 4 (August 17, 1994): 793–99. https://doi.org/10.1016/0006-2952(94)90058-2.
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    • Friedman, H. S., M. E. Dolan, S. H. Kaufmann, O. M. Colvin, O. W. Griffith, R. C. Moschel, S. C. Schold, D. D. Bigner, and F. Ali-Osman. “Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.” Cancer Res 54, no. 13 (July 1, 1994): 3487–93.
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    • Aggarwal, B. B., K. Totpal, F. Ali-Osman, R. J. Budde, and E. Pocsik. “pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.” Febs Lett 345, no. 2–3 (May 30, 1994): 219–24. https://doi.org/10.1016/0014-5793(94)00441-2.
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    • Pocsik, E., R. Mihalik, F. Ali-Osman, and B. B. Aggarwal. “Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response.” J Cell Biochem 54, no. 4 (April 1994): 453–64. https://doi.org/10.1002/jcb.240540412.
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    • Sawaya, R., P. J. Tofilon, S. Mohanam, F. Ali-Osman, L. A. Liotta, W. G. Stetler-Stevenson, and J. S. Rao. “Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes.” Int J Cancer 56, no. 2 (January 15, 1994): 214–18. https://doi.org/10.1002/ijc.2910560212.
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    • Ali-Osman, F., M. S. Berger, A. Rairkar, and D. E. Stein. “Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy.” J Cell Biochem 54, no. 1 (January 1994): 11–19. https://doi.org/10.1002/jcb.240540103.
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    • Rao, J. S., P. A. Steck, P. Tofilon, D. Boyd, F. Ali-Osman, W. G. Stetler-Stevenson, L. A. Liotta, and R. Sawaya. “Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model.” J Neurooncol 18, no. 2 (1994): 129–38. https://doi.org/10.1007/BF01050419.
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    • Ali-Osman, F., M. S. Berger, S. Rajagopal, A. Spence, and R. B. Livingston. “Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells.” Cancer Res 53, no. 23 (December 1, 1993): 5663–68.
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    • Ishikawa, T., and F. Ali-Osman. “Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.” J Biol Chem 268, no. 27 (September 25, 1993): 20116–25.
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    • Mohanam, S., R. Sawaya, I. McCutcheon, F. Ali-Osman, D. Boyd, and J. S. Rao. “Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody.” Cancer Res 53, no. 18 (September 15, 1993): 4143–47.
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    • Sriram, R., and F. Ali-Osman. “Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line.” Biochem Mol Biol Int 30, no. 6 (August 1993): 1053–60.
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    • Silbergeld, D. L., M. R. Mayberg, M. S. Berger, F. Ali-Osman, W. A. Kelly, and C. M. Shaw. “Pituitary oncocytomas: clinical features, characteristics in cell culture, and treatment recommendations.” J Neurooncol 16, no. 1 (April 1993): 39–46. https://doi.org/10.1007/BF01324833.
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    • Genka, S., J. Deutsch, U. H. Shetty, P. L. Stahle, V. John, I. M. Lieberburg, F. Ali-Osman, S. I. Rapoport, and N. H. Greig. “Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil.” Clin Exp Metastasis 11, no. 2 (March 1993): 131–40. https://doi.org/10.1007/BF00114971.
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    • Spence, A. M., M. S. Berger, R. B. Livingston, F. Ali-Osman, and B. Griffin. “Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure.” J Neurooncol 12, no. 2 (February 1992): 187–91. https://doi.org/10.1007/BF00172671.
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    • Silbergeld, D. L., F. Ali-Osman, and H. R. Winn. “Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells.” J Neurosurg 75, no. 4 (October 1991): 604–12. https://doi.org/10.3171/jns.1991.75.4.0604.
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    • Silbergeld, D. L., and F. Ali-Osman. “Isolation and characterization of microvessels from normal brain and brain tumors.” J Neurooncol 11, no. 1 (August 1991): 49–55. https://doi.org/10.1007/BF00166997.
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    • Ali-Osman, F., D. E. Stein, and A. Renwick. “Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines.” Cancer Res 50, no. 21 (November 1, 1990): 6976–80.
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    • Ali-Osman, F., and D. Schofield. “Cellular and molecular studies in brain and nervous system oncology.” Curr Opin Oncol 2, no. 4 (August 1990): 655–65.
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    • Srivenugopal, K. S., and F. Ali-Osman. “Stimulation and inhibition of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced strand breaks and interstrand cross-linking in Col E1 plasmid deoxyribonucleic acid by polyamines and inorganic cations.” Biochem Pharmacol 40, no. 3 (August 1, 1990): 473–79. https://doi.org/10.1016/0006-2952(90)90545-v.
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    • Sriram, R., and F. Ali-Osman. “S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells.” Anal Biochem 187, no. 2 (June 1990): 345–48. https://doi.org/10.1016/0003-2697(90)90467-n.
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    • Ali-Osman, F., K. Srivenugopal, M. S. Berger, and D. E. Stein. “DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance.” Anticancer Res 10, no. 3 (May 1990): 677–82.
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    • Canady, K. S., F. Ali-Osman, and E. W. Rubel. “Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells.” Glia 3, no. 5 (1990): 368–74. https://doi.org/10.1002/glia.440030508.
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    • Ali-Osman, F., J. Caughlan, and G. S. Gray. “Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione.” Cancer Res 49, no. 21 (November 1, 1989): 5954–58.
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    • Ali-Osman, F. “Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.” Cancer Res 49, no. 19 (October 1, 1989): 5258–61.
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    • Ali-Osman, F., and P. A. Beltz. “Optimization and characterization of the capillary human tumor clonogenic cell assay.” Cancer Res 48, no. 3 (February 1, 1988): 715–24.
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    • Ali-Osman, F., J. Giblin, D. Dougherty, and M. L. Rosenblum. “Application of in vivo and in vitro pharmacokinetics for physiologically relevant drug exposure in a human tumor clonogenic cell assay.” Cancer Res 47, no. 14 (July 15, 1987): 3718–24.
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    • Moezzi, J., F. Ali-Osman, and M. J. Murphy. “Rapid method for permanent slide preparation of colonies in soft agar cultures.” Int J Cell Cloning 4, no. 5 (September 1986): 368–74. https://doi.org/10.1002/stem.5530040508.
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    • Moezzi, J., F. Ali-Osman, G. L. Nicholson, J. S. Ungerleider, and M. J. Murphy. “Relationship between histopathology and in vitro clonogenicity in breast cancer.” Breast Cancer Res Treat 8, no. 2 (1986): 147–56. https://doi.org/10.1007/BF01807703.
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    • Hübner, G. E., F. Ali-Osman, M. Kastner, C. Papadimitriou, and H. R. Maurer. “Reculturing of cells from primary CFU-C colonies.” Z Naturforsch C Biosci 40, no. 11–12 (November 1985): 891–97.
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    • Ali-Osman, F., J. Giblin, M. Berger, M. J. Murphy, and M. L. Rosenblum. “Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas.” Cancer Res 45, no. 9 (September 1985): 4185–91.
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    • Ali-Osman, F., M. L. Rosenblum, D. D. Giannini, and V. A. Levin. “Potential antiglioma activity of 9-hydroxy-2-N-methylellipticine as determined by pharmacological and human tumor clonogenic cell studies.” Cancer Res 45, no. 7 (July 1985): 2988–92.
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    • Ali-Osman, F., J. Giblin, and M. Berger. “In vitro bone marrow cytotoxicity of nitrosoureas: Possible role for carbamoylation.” Proceedings of the American Association for Cancer Research VOL. 26 (January 1, 1985).
    • Berger, M. S., R. E. Talcott, M. L. Rosenblum, M. Silva, F. AliOsman, and M. T. Smith. “Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations.” J Toxicol Environ Health 16, no. 5 (1985): 713–19. https://doi.org/10.1080/15287398509530781.
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    • Dittmar, W., G. Klitschka, R. Braun, F. Ali-Osman, C. Meckert, and H. R. Maurer. “In vitro and in vivo investigations for the development of cytostatic methylhydrazones.” J Cancer Res Clin Oncol 110, no. 2 (1985): 110–14. https://doi.org/10.1007/BF00402721.
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    • Maurer, H. R., C. Meckert, F. Ali-Osman, and J. Musil. “Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU).” Arzneimittelforschung 34, no. 9 (1984): 939–43.
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    • Osman, F. A., J. Bier, H. Bier, T. Siegel, H. R. Maurer, and S. Ohanian. “Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity.” Int J Cell Cloning 1, no. 2 (June 1983): 118–27. https://doi.org/10.1002/stem.5530010206.
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    • Ali Osman, F., H. R. Maurer, and J. Bier. “In vitro cytostatic drug sensitivity testing in the human tumor stem cell assay: A modified method for the determination of the sensitivity index.” Tumor Diagnostik Und Therapie 4, no. 1 (January 1, 1983): 1–6.
    • Ali-Osman, F., and H. R. Maurer. “Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity.” J Cancer Res Clin Oncol 106, no. 1 (1983): 17–20. https://doi.org/10.1007/BF00399892.
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    • Neumeier, R., F. Ali-Osman, and H. R. Maurer. “Two different types of granulocyte colony-stimulating factor produced by bovine lung tissue.” Blut 44, no. 1 (January 1982): 21–27. https://doi.org/10.1007/BF00320683.
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    • Maurer, H. R., and F. Ali-Osman. “Tumor stem cell cloning in agar-containing capillaries.” Naturwissenschaften 68, no. 7 (July 1981): 381–83. https://doi.org/10.1007/BF01058036.
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    • Ali-Osman, F., and H. R. Maurer. “Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays.” J Cancer Res Clin Oncol 98, no. 3 (1980): 221–31. https://doi.org/10.1007/BF00410786.
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    • Osman, F. A., and H. R. Maurer. “Comparative cell kinetic studies of the L1210 leukemic line differential, effects of cytostatics and a lymphocyte chalone extract on this cell line and on peripheral human lymphocytes after PHA-stimulation.” Cell and Tissue Kinetics 13, no. 2 (January 1, 1980).

  • Book Sections

    • Buolamwini, J. K., and F. Ali-Osman. “Dynamic docking study of the binding of 1-chloro-2,4-dinitrobenzene in the putative electrophile binding site of naturally occurring human glutathione s-transferase pi allelo-polymorphic proteins.” In Biologically Active Natural Products: Pharmaceuticals, 188–98, 1999. https://doi.org/10.1201/9781420048650.
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  • Other Articles

    • Augustine, C. K., J. S. Yoo, A. Potti, Y. Yoshimoto, P. A. Zipfel, H. S. Friedman, J. R. Nevins, F. Ali-Osman, and D. S. Tyler. “Correction: Article on genomic and molecular profiling to predict response to temozolomide (Clinical Cancer Research (2009) 15, (502-510)).” Clinical Cancer Research, May 1, 2009. https://doi.org/10.1158/1078-0432.CCR-15-9-COR.
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  • Conference Papers

    • Amirian, E Susan, Georgina Armstrong, Renke Zhou, Margaret Wrensch, Sara Olson, Michael Scheurer, Dora Il’yasova, et al. “DEMOGRAPHICS AND LIFESTYLE FACTORS IN GLIOMA RISK: A REPORT FROM THE GLIOMA INTERNATIONAL CASE-CONTROL STUDY.” In Neuro Oncology, 18:57–58. OXFORD UNIV PRESS INC, 2016.
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    • Advani, Anjali S., William Tse, Xuefei Jia, Paul Elson, Brenda Cooper, Francis Ali-Osman, Jino Park, et al. “Long-Term Follow-up Results: A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed c-Kit Positive Acute Myeloid Leukemia (AML).” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Lidsky, M. E., R. S. Turley, P. Speicher, C. K. Augustine, F. Ali-Osman, and D. S. Tyler. “Termination of BRAF Targeted Therapy Augments Tumor Growth in the Setting of Vemurafenib Resistance.” In Annals of Surgical Oncology, 20:S90–S90. SPRINGER, 2013.
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    • Flores, Rafael Diaz, Fernando Rivera, John Zink, Colleen Stoeppel, Francis Ali-Osman, Ming-Mei Liu, Joseph Minei, and Christian Minshall. “ADRENOMEDULLIN (ADM) LEVELS IN BONCHOALVEOLAR LAVAGE (BAL) PREDICT VENTILATOR ASSOCIATED PNEUMONIA (VAP) IN PATIENTS WITH A HIGH CLINICAL PULMONARY INFECTION SCORE (CPIS).” In Critical Care Medicine, 40:U114–U114, 2012.
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    • Advani, Anjali, Brenda Cooper, Olumuyiwa Sowunmi, Paul Elson, Francis Ali-Osman, Jino Park, Arati Rao, et al. “A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed C-Kit Positive Acute Myeloid Leukemia (AML).” In Blood, Vol. 120. AMER SOC HEMATOLOGY, 2012.
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    • Antoun, Gamil R., R. McLendon, H. Friedman, A. Friedman, D. Bigner, and F. Ali-Osman. “The mutational status of the p53 tumor suppressor gene is a determinant of GSTP1 expression and mediates GSTP1-dependent drug resistance in human glioblastoma.” In Cancer Research, Vol. 72, 2012. https://doi.org/10.1158/1538-7445.AM2012-1177.
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    • Cao, Xinyu, Hu Zhu, Darell Bigner, Francis Ali-Osman, and Hui-Wen Lo. “GAIN-OF-FUNCTION tGLI1 TRANSCRIPTION FACTOR AUGMENTS ANCHORAGE-INDEPENDENT GROWTH OF MEDULLOBLASTOMA CELLS AND CONFERS THEIR RESISTANCE TO SMO INHIBITORS.” In Neuro Oncology, 13:I9–I9. OXFORD UNIV PRESS INC, 2011.
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    • Cao, Xinyu, Hu Zhu, Darell Bigner, Francis Ali-Osman, and Hui-Wen Lo. “EGFR AND EGFRvIII UNDERGO STRESS- AND EGFR KINASE INHIBITOR-INDUCED MITOCHONDRIAL TRANSLOCALIZATION IN GLIOBLASTOMA: A POTENTIAL MECHANISM OF EGFR- AND EGFRvIII-DRIVEN ANTAGONISM OF APOPTOSIS AND DRUG RESPONSE.” In Neuro Oncology, 13:I8–9. OXFORD UNIV PRESS INC, 2011.
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    • Zhu, Hu, Xinyu Cao, Steve Keir, Darell Bigner, Francis Ali-Osman, and Hui-Wen Lo. “UPREGULATION OF VEGF-A GENE EXPRESSION BY THE tGLI1 TRANSCRIPTION FACTOR CONTRIBUTES TO GLIOBLASTOMA ANGIOGENESIS.” In Neuro Oncology, 13:I15–16. OXFORD UNIV PRESS INC, 2011.
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    • Zhu, Hu, Xinyu Cao, Steve Keir, Francis Ali-Osman, and Hui-Wen Lo. “UNDERSTANDING AND TARGETING KINASE-INDEPENDENT ACTIVITY OF EGFR AND EGFRVIII TO OVERCOME GBM DRUG RESISTANCE.” In Neuro Oncology, 12:8–8. OXFORD UNIV PRESS INC, 2010.
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    • Ali-Osman, Francis, Kouros Owzar, Bartley Adams, Eric Lipp, James Herdon, Dora Illyasova, Faith Davis, et al. “GENETIC DIVERSITY ASSOCIATED WITH SURVIVAL IN MALIGNANT GLIOMAS IDENTIFIED BY LINKAGE DISEQUILIBRIUM-BASED ANALYSIS OF HAPLOTYPE BLOCK REGIONS OF DNA REPAIR GENES.” In Neuro Oncology, 11:891–891. OXFORD UNIV PRESS INC, 2009.
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    • Okamura, Tatsunori, and Francis Ali-Osman. “DIRECT TYROSINE PHOSPHORYLATION OF GSTP1 BY EGFR INDUCES JNK ACTIVATION IN GLIOBLASTOMA CELLS.” In Neuro Oncology, 11:894–894. OXFORD UNIV PRESS INC, 2009.
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    • Lo, Hui-Wen, Lisa Stephenson, Xinyu Cao, Raphael Pollock, Mira Milas, and Francis Ali-Osman. “IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN GSTP1 GENE AS A NOVEL TRANSCRIPTIONAL TARGET OF THE P53 TUMOR SUPPRESSOR GENE.” In Neuro Oncology, 10:766–766. OXFORD UNIV PRESS INC, 2008.
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    • Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “CONSTITUTIVE STAT3 ACTIVATION FREQUENTLY COEXISTS WITH EGFR EXPRESSION IN HIGH-GRADE GLIOMAS AND TARGETING STAT3 SENSITIZES THEM TO ANTI-EGFR AND ALKYLATING AGENTS.” In Neuro Oncology, 10:766–766. OXFORD UNIV PRESS INC, 2008.
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    • Okamura, Tatsunori, Simendra Singh, Darell Bigner, and Francis Ali-Osman. “LIGAND-DEPENDENT ACTIVATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INDUCES EARLY DRUG RESISTANCE IN BRAIN TUMOR CELLS VIA ACTIVATION OF ITS DOWNSTREAM TARGET GLUTATHIONE S-TRANSFERASE P1.” In Neuro Oncology, 10:782–782. OXFORD UNIV PRESS INC, 2008.
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    • Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Stat3 constitutive activation is associated with glioma tumor grade: Pathway profiling and therapy.” In Neuro Oncology, 9:550–550. DUKE UNIV PRESS, 2007.
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    • Lo, Hui-Wen, Xinyu Cao, Hu Zhu, and Francis Ali-Osman. “Targeting constitutively activated stat3 sensitizes medulloblastomas to chemotherapeutic agents.” In Neuro Oncology, 9:560–560. DUKE UNIV PRESS, 2007.
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    • Wang, Jiangbo, Renshui Liu, Michael Bond, Minyong Chen, Simandra Singh, Francis Ali-Osman, Robert J. Lefkowitz, et al. “Targeting hedgehog signaling in medulloblastoma.” In Neuro Oncology, 9:560–61. DUKE UNIV PRESS, 2007.
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    • Ali-Osman, Francis. “Polymorphism of the promoter of the epidermal growth factor (EGF) gene in patients, its distribution and correlation with survival in glioma patients.” In Neuro Oncology, 8:420–420. DUKE UNIV PRESS, 2006.
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    • Okamura, Tatsunori, Timothy Haystead, Darell D. Bigner, and Francis Ali-Osman. “Glutathione S-transferase P1 (GSTP1) is a novel downstream target of Akt in human gliomas.” In Neuro Oncology, 8:400–400. DUKE UNIV PRESS, 2006.
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    • Yoo, J., C. K. Augustine, Y. Yoshimoto, R. P. Petersen, S. K. Pruitt, F. Ali-Osman, and D. S. Tyler. “Role of BAY 43-9006 in combination with temozolomide and melphalan in metastatic melanoma.” In Annals of Surgical Oncology, 13:12–12. SPRINGER, 2006.
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    • Wanko, S. O., J. P. Gockerman, J. O. Moore, C. de Castro, L. Diehl, R. Pronitz, C. Gasparetto, et al. “Multimodal dose dense therapy for mantle cell lymphoma.” In Blood, 106:463B-463B. AMER SOC HEMATOLOGY, 2005.
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    • Yoo, Jin S., Yasunori Yoshimoto, Rebecca P. Petersen, Scott K. Pruitt, Francis Ali-Osman, and Douglas S. Tyler. “Glutathione S-transferase as a marker of metastatic potential in malignant melanoma.” In Journal of the American College of Surgeons, 201:S84–S84. Elsevier BV, 2005. https://doi.org/10.1016/j.jamcollsurg.2005.06.197.
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    • Ali-Osman, F., H. Lo, G. Antoun, A. Friedman, H. Friedman, and D. Bigner. “A novel mechanism of PKA- and PKC-dependent drug resistance in human gliomas involving phosphorylation and metabolic activation of glutathione S-transferase P1 (GSTP1).” In Neuro Oncology, 7:377–377. DUKE UNIV PRESS, 2005.
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    • Ali-Osman, F., J. E. Herndon, L. Stephenson, F. Davis, B. McCarthy, D. Reardon, A. Friedman, R. McClendon, H. Friedman, and D. D. Bigner. “Prevalence and prognostic significance of polymorphisms at the glutathione S-transferase M1, M3, P1, and T1 gene loci in human astrocytomas.” In Neuro Oncology, 7:304–304. DUKE UNIV PRESS, 2005.
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    • Ishimoto, T., and F. Ali-Osman. “Pharmacogenetics of the human glutathione S-transferase P1 gene and tumor response to chemotherapy.” In European Journal of Cancer, 38:S157–58, 2002.
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    • Scholl, R., M. Blandford, L. Ballard, J. B. Magee, S. Williams, M. Robertson, F. Ali-Osman, R. Lemons, and C. Keller. “A high throughput fluorescent assay for the detection of glutathione S-transferase polymorphic alleles.” In American Journal of Human Genetics, 71:463–463, 2002.
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