Charles Franklin Starmer
Professor Emeritus of Computer Science
Though trained formally as an electrical engineer, I found myself starting my career in the Cardiology Division of the Department of Medicine. My first research project was to explore the nature of electically induced ventricular fibrillation - an introduction to reentrant cardiac arrhythmias. Though VF is complex, this work ignited my curioisity about the underlying nature of cellular communication - whether electrical via gap junctions or chemical via ligand-receptor interactions. Along the way, I found myself developing the computational infrastructure for the Cardiology Databank, starting the Computer Science Department and eventually finding my way to the laboratory. With my long term collaborator, Gus Grant, we explored single cardiac ion channels, drug interactions with cardiac ion channels and found ourselves facing my initial interests in reentrant cardiac arrhythmias, in this case, induced by drug-channel interactions. The modeling of cardiac and neuronal action potentials resulted in identifying the determinants of the cardiac vulnerable period and today is referred to as computational biology. Computational biology has the unique feature of providing a direct look at underlying modeled processes in contrast to laboratory investigations where much is hidden. For me, identifying the physical basis of generic biological processes (e.g. excitation, propagation, ligand-receptor binding and transporters) via computational models is simply great fun.
Current Appointments & Affiliations
- Professor Emeritus of Computer Science, Computer Science, Trinity College of Arts & Sciences 1997
Contact Information
- 2424 Erwin Road Ste G04, Hock Plaza Ste G04 Duke Box 27, Durham, NC 27705
- Duke Box 2741, Durham, NC 27710
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frank.starmer@duke.edu
(919) 684-0753
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Duke-NUS Graduate Medical School Singapore
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Frank's Photo Essays
- Background
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Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 1968
- M.S.E.E., Duke University 1965
- B.S.E.E., Duke University 1963
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Duke Appointment History
- Professor of Biostatistics and Bioinformatics, with tenure, Biostatistics & Bioinformatics, Basic Science Departments 2006 - 2015
- Instructor Temporary in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2006
- Professor with Tenure, Computer Science, Trinity College of Arts & Sciences 1978 - 1997
- Professor of Experimental Medicine, Medicine, Clinical Science Departments 1990 - 1994
- Associate Professor with Tenure, Computer Science, Trinity College of Arts & Sciences 1971 - 1978
- Assistant Professor, Medicine, Clinical Science Departments 1971 - 1977
- Assistant Professor, Computer Science, Trinity College of Arts & Sciences 1968 - 1971
- Assistant Professor, Family Medicine and Community Health, Clinical Science Departments 1969 - 1971
- Associate, Computer Science, Trinity College of Arts & Sciences 1966 - 1968
- Recognition
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In the News
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OCT 29, 2013 Today
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- Expertise
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Subject Headings
- Action Potentials
- Adolescent
- Aged
- Amino Acid Substitution
- Analog-Digital Conversion
- Anti-Arrhythmia Agents
- Arrhythmias, Cardiac
- Atrial Fibrillation
- Automatic Data Processing
- Axons
- Beds
- Binding Sites
- Biomedical Engineering
- Biomedical Research
- Biometry
- Biophysical Phenomena
- Biophysics
- Body Weight
- Cardiac Output
- Cardiovascular System
- Catheterization
- Computer Simulation
- Computers
- Consumer behavior
- Coronary Disease
- Costs and Cost Analysis
- Death, Sudden, Cardiac
- Differential Threshold
- Disopyramide
- Dose-Response Relationship, Drug
- Drug Combinations
- Electrophysiology
- Female
- Flecainide
- Gap Junctions
- Gene Silencing
- Glutamine
- Heart Conduction System
- Hemodynamics
- Humans
- Indicator Dilution Techniques
- Ion Channel Gating
- Ion Channels
- Lidocaine
- Long QT Syndrome
- Male
- Membrane Potentials
- Middle Aged
- Models, Biological
- Models, Theoretical
- Muscle Proteins
- Muscles
- Mutagenesis, Site-Directed
- Mutation
- Myocardial Ischemia
- Myocardium
- Myocytes, Cardiac
- NAV1.5 Voltage-Gated Sodium Channel
- Nervous System
- Nitrates
- Nitriles
- Nitrogen Isotopes
- Nitroglycerin
- Octanols
- Operations Research
- Oscillometry
- Osmolar Concentration
- Outcome and Process Assessment (Health Care)
- Oxygen
- Oxygen Inhalation Therapy
- Patch-Clamp Techniques
- Pedigree
- Pentosephosphates
- Peptide Mapping
- Peptides
- Periodicity
- Phenothiazines
- Phenotype
- Phenylalanine
- Population
- Potassium Channel Blockers
- Probability
- Prognosis
- Propafenone
- Propiophenones
- Pulmonary Edema
- Purines
- Questionnaires
- Quinidine
- Rabbits
- Random Allocation
- Receptors, Drug
- Recombinant Proteins
- Refractory Period, Electrophysiological
- Registries
- Reminder Systems
- Research
- Review
- Rheology
- Seizures
- Sensitivity and Specificity
- Sequence Deletion
- Signal Processing, Computer-Assisted
- Sodium Channel Blockers
- Sodium Channels
- Software
- Solubility
- Spermatozoa
- Statistics as Topic
- Stochastic Processes
- Surface Properties
- Syndrome
- Tachycardia
- Technology
- Technology, Radiologic
- Time Factors
- Transfection
- Transplantation, Autologous
- Water
- Research
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Selected Grants
- Electrophysiology Responses To Ion Channel Blockade awarded by National Institutes of Health 1984 - 1998
- Electrophysiolgic Responses To Ion Channel Blockade awarded by National Institutes of Health 1984 - 1997
- Electrophysiologic Responses To Ion Channel Blockade awarded by National Institutes of Health 1984 - 1997
- Pharmacology Of Unitary Conductances In Cardiac Muscle awarded by National Institutes of Health 1993 - 1994
- Models Of Ion Channel Blockade By Antiarrhythmic Agents awarded by National Institutes of Health 1991 - 1992
- Models Of Icon Channel Blockade By Antiarrhythmic Agents awarded by National Institutes of Health 1990 - 1992
- Models Of Ion Channel Blockade By Antiarrythmic Agents awarded by National Institutes of Health 1988 - 1992
- Models Of Ion Channel Blockade By Antiarrhythmic Drugs awarded by National Institutes of Health 1987 - 1992
- Models Of Excitation-Secretion Coupling In Pituitary Cells awarded by Office of Naval Research 1987 - 1990
- Models Of Drug Binding To Cardiac Sodium Channels awarded by National Institutes of Health 1986 - 1987
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Beaumont, J. O., W. A. Radke, J. Trotter, N. Palley, D. Erbeck, H. Shubin, R. A. Rosati, et al. “SAN DIEGO BIOMEDICAL SYMPOSIUM, 1971, PROCEEDINGS, v 10.,” January 1, 2020.
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Beaumont, J. O., W. A. Radke, J. Trotter, N. Palley, D. Erbeck, H. Shubin, R. A. Rosati, et al. “SAN DIEGO BIOMEDICAL SYMPOSIUM, 1971, PROCEEDINGS, v 10.,” January 1, 2017.
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Starmer, C. F. “Feedback stabilization of control policy selection in data/knowledge based systems.” Proceedings International Conference on Data Engineering 2015-September (September 14, 2015): 586–91. https://doi.org/10.1109/ICDE.1984.7271322.Full Text
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Romero, Lucia, Beatriz Trenor, Jose M. Ferrero, and C Frank Starmer. “Non-uniform dispersion of the source-sink relationship alters wavefront curvature.” Plos One 8, no. 11 (January 2013): e78328. https://doi.org/10.1371/journal.pone.0078328.Full Text
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Cardona, Karen, Beatriz Trénor, Germán Moltó, Miguel Martínez, José María Ferrero, Frank Starmer, and Javier Saiz. “Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue.” American Journal of Physiology. Heart and Circulatory Physiology 299, no. 5 (November 2010): H1615–24. https://doi.org/10.1152/ajpheart.00425.2010.Full Text
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Starmer, C Frank. “Exploring reentrant arrhythmias with numerical experiments: generic properties and model complexity.” Journal of Cardiovascular Electrophysiology 20, no. 6 (June 2009): 685–88. https://doi.org/10.1111/j.1540-8167.2009.01435.x.Full Text
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Cam, H. T., and F. Starmer. “Investigative methods and tools: Developing an integrated approach to critical thinking, evidence-based medicine and biostatistics.” Singapore General Hospital Proceedings 17, no. 3 (December 1, 2008): 160–63.
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Starmer, C Frank. “The role of intrinsic and induced vulnerability in electrically induced cardiac arrhythmias.” Journal of Cardiovascular Electrophysiology 17, no. 12 (December 2006): 1369–70. https://doi.org/10.1111/j.1540-8167.2006.00642.x.Full Text
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Carboni, M., Z. -. S. Zhang, V. Neplioueva, C. F. Starmer, and A. O. Grant. “Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue.” J Membr Biol 207, no. 2 (September 2005): 107–17. https://doi.org/10.1007/s00232-005-0805-0.Full Text Link to Item
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Starmer, C Frank, A. O. Grant, and T. J. Colatsky. “What happens when cardiac Na channel function is compromised? 2. Numerical studies of the vulnerable period in tissue altered by drugs.” Cardiovasc Res 57, no. 4 (March 15, 2003): 1062–71. https://doi.org/10.1016/s0008-6363(02)00727-7.Full Text Link to Item
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Cimponeriu, Adrian, C Frank Starmer, and Anastasios Bezerianos. “Ischemic modulation of vulnerable period and the effects of pharmacological treatment of ischemia-induced arrhythmias: a simulation study.” Ieee Transactions on Bio Medical Engineering 50, no. 2 (February 2003): 168–77. https://doi.org/10.1109/tbme.2002.807656.Full Text
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Kapela, A., C. F. Starmer, and A. Bezerianos. “Slow conduction within infarct scars as a source of high-frequency oscillations in the QRS signal.” Computers in Cardiology 30 (January 1, 2003): 5–8. https://doi.org/10.1109/cic.2003.1291076.Full Text
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Starmer, C Frank, Thomas J. Colatsky, and Augustus O. Grant. “What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels.” Cardiovasc Res 57, no. 1 (January 2003): 82–91. https://doi.org/10.1016/s0008-6363(02)00613-2.Full Text Link to Item
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Starmer, C. F. “Erratum: Hitting a moving target: Toward a compliance-driven patient record (Journal of the American Medical Informatics Association (November/December 2002) 9:6 (659-660)).” Journal of the American Medical Informatics Association 10, no. 1 (January 1, 2003): 107.
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Starmer, C Frank. “Hitting a moving target: toward a compliance-driven patient record.” Journal of the American Medical Informatics Association : Jamia 9, no. 6 (November 2002): 659–60. https://doi.org/10.1197/jamia.m1153.Full Text
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Grant, Augustus O., Michael P. Carboni, Valentina Neplioueva, C Frank Starmer, Mirella Memmi, Carlo Napolitano, and Silvia Priori. “Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation.” J Clin Invest 110, no. 8 (October 2002): 1201–9. https://doi.org/10.1172/JCI15570.Full Text Link to Item
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Starmer, C. F. “How antiarrhythmic drugs increase the rate of sudden cardiac death.” International Journal of Bifurcation and Chaos in Applied Sciences and Engineering 12, no. 9 (September 1, 2002): 1953–68. https://doi.org/10.1142/S0218127402005625.Full Text
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Moskalenko, A. V., N. I. Kukushkin, C. F. Starmer, A. A. Deev, K. N. Kukushkina, and A. B. Medvinsky. “A quantitative analysis of variability of the electrocardiograms typical of polymorphic arrhythmias.” Biofizika 46, no. 2 (December 1, 2001).
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Moskalenko, A. V., N. I. Kukushkin, C. F. Starmer, A. A. Deev, K. N. Kukushkina, and A. B. Medvinskiĭ. “[Quantitative analysis of variability of electrocardiograms typical for polymorphic arrhythmias].” Biofizika 46, no. 2 (March 2001): 319–29.
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Moskalenko, A. V., N. I. Kukushkin, C. F. Starmer, A. A. Deev, K. N. Kukushkina, and A. B. Medvinskiǐ. “Quantitative analysis of variability of electrocardiograms typical for polymorphic arrhythmias.” Biofizika 46, no. 2 (March 1, 2001): 319–29.
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Cimponeriu, A., C. F. Starmer, and A. Bezerianos. “A theoretical analysis of acute ischemia and infarction using ECG reconstruction on a 2-D model of myocardium.” Ieee Transactions on Bio Medical Engineering 48, no. 1 (January 2001): 41–54. https://doi.org/10.1109/10.900247.Full Text
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Cimponeriu, A., C. F. Starmer, and A. Bezerianos. “Antiarrhythmic drug effect analysis on a model of cardiac fiber.” Computers in Cardiology, December 1, 2000, 517–20.
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Grant, A. O., R. Chandra, C. Keller, M. Carboni, and C. F. Starmer. “Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells.” Biophys J 79, no. 6 (December 2000): 3019–35. https://doi.org/10.1016/S0006-3495(00)76538-6.Full Text Link to Item
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Bountis, T., C. F. Starmer, and A. Bezerianos. “Stationary pulses and wave front formation in an excitable medium.” Progress of Theoretical Physics Supplement, no. 139 (January 1, 2000): 12–33. https://doi.org/10.1143/PTPS.139.12.Full Text
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Cimponeriu, A., C. F. Starmer, and A. Bezerianos. “Modeling of ventricular tissue and ECG reconstruction in acute and chronic ischemia.” Computers in Cardiology, December 1, 1999, 503–6.
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Chandra, R., V. S. Chauhan, C. F. Starmer, and A. O. Grant. “beta-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity.” Cardiovasc Res 42, no. 2 (May 1999): 490–502. https://doi.org/10.1016/s0008-6363(99)00042-5.Full Text Link to Item
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Cimponeriu, A., C. F. Starmer, and A. Bezerianos. “Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling.” Computers in Cardiology 0, no. 0 (December 1, 1998): 317–20.
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Kukushkin, N. I., V Iu Sidorov, A. B. Medvinskiĭ, D. N. Romashko, A Iu Burashnikov, O. V. Baum, D Iu Sarancha, and C. F. Starmer. “[Slow excitation waves and mechanisms of polymorphic ventricular tachycardia in an experimental model: isolated walls of the right ventricle from rabbit and squirrel].” Biofizika 43, no. 6 (November 1998): 1043–59.
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Kukushkin, N. I., V. I. Sidorov, A. B. Medvinskii, D. N. Romashko, A. I. Burashnikov, O. V. Baum, D. I. Sarancha, and C. F. Starmer. “Slow excitation waves and mechanisms of polymorphic ventricular tachycardia in an experimental model: isolated walls of the right ventricle from rabbit and squirrel.” Biofizika 43, no. 6 (November 1, 1998): 1043–59.
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Chandra, R., C. F. Starmer, and A. O. Grant. “Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells.” American Journal of Physiology Heart and Circulatory Physiology 274, no. 5 43-5 (May 1, 1998).
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Kukushkin, N. I., V. Y. Sidorov, A. B. Medvinskii, D. N. Romashko, A. Y. Burashnikov, O. V. Baum, D. Y. Sarancha, and C. F. Starmer. “Slow Excitation Waves and Mechanisms of Polymorphic Ventricular Tachycardia in the Experimental Model: Isolated Walls of Rabbit and Ground Squirrel Right Ventricle.” Biofizika 43, no. 6 (January 1, 1998): 1058–59.
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Starobin, J. M., and C. F. Starmer. “Boundary-layer analysis of a spiral wave core.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 1997): 5–8.
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Sarancha, D. I. U., A. B. Medvinskiĭ, N. I. Kukushkin, V. V. Sidorov, D. N. Romashko, A. I. U. Burashnikov, A. V. Moskalenko, and C. F. Starmer. “[A system for computer visualization of excitation wave propagation in the myocardium].” Biofizika 42, no. 2 (March 1997): 502–7.
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Sarancha, D. I., A. B. Medvinskii, N. I. Kukushkin, V. V. Sidorov, D. N. Romashko, A. I. Burashnikov, A. V. Moskalenko, and C. F. Starmer. “A system for computer visualization of excitation wave propagation in the myocardium.” Biofizika 42, no. 2 (March 1, 1997): 502–7.
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Starmer, C. F. “The cardiac vulnerable period and reentrant arrhythmias: targets of anti- and proarrhythmic processes.” Pacing and Clinical Electrophysiology : Pace 20, no. 2 Pt 2 (February 1997): 445–54. https://doi.org/10.1111/j.1540-8159.1997.tb06203.x.Full Text
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Sarancha, D. Y., A. B. Medvinsky, N. I. Kukushkin, V. V. Sidorov, D. N. Romashko, A. Y. Burashnikov, A. V. Moskalenko, and C. F. Starmer. “A system for computer-aided visualization of propagation of excitation waves in myocardium.” Biofizika 42, no. 2 (January 1, 1997).
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Starobin, J. M., C. F. Starmer, and A. J. Starobin. “Boundary-layer analysis of a spiral wave core: Spiral core radius and conditions for the tip separation from the core boundary.” Physical Review E Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 56, no. 4 (January 1, 1997): R3757–60. https://doi.org/10.1103/PhysRevE.56.R3757.Full Text
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Starobin, J. M., and C. F. Starmer. “Common mechanism links spiral wave meandering and wave-front–obstacle separation.” Physical Review E Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 55, no. 1 (January 1, 1997): 1193–96. https://doi.org/10.1103/PhysRevE.55.1193.Full Text
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Grant, A. O., J. E. John, V. V. Nesterenko, C. F. Starmer, and J. R. Moorman. “The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels.” Molecular Pharmacology 50, no. 6 (December 1996): 1643–50.
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Mornev, O. A., O. V. Aslanidi, L. M. Chailakhyan, and C. F. Starmer. “Splitting of the back front of propagating pulse of excitation.” Biofizika 41, no. 1 (December 1, 1996).
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Starobin, J. M., and C. F. Starmer. “Spiral wave meandering and wavefront-obstacle separation.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 3 (December 1, 1996): 1252–53.
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Starobin, J. M., and C. F. Starmer. “Spiral wave meandering, wavefront - Obstacle separation and cardiac arrhythmias.” Computers in Cardiology 0, no. 0 (December 1, 1996): 233–36.
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Starobin, J. M., and C. F. Starmer. “Boundary-layer analysis of waves propagating in an excitable medium: Medium conditions for wave-front-obstacle separation.” Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 54, no. 1 (July 1996): 430–37. https://doi.org/10.1103/physreve.54.430.Full Text
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Starobin, J. M., Y. I. Zilberter, E. M. Rusnak, and C. F. Starmer. “Wavelet formation in excitable cardiac tissue: the role of wavefront-obstacle interactions in initiating high-frequency fibrillatory-like arrhythmias.” Biophysical Journal 70, no. 2 (February 1996): 581–94. https://doi.org/10.1016/s0006-3495(96)79624-8.Full Text
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Liu, L., V. I. Krinsky, A. O. Grant, and C. F. Starmer. “Cardiac transient outward potassium current: a pulse chemistry model of frequency-dependent properties.” Am J Physiol 270, no. 1 Pt 2 (January 1996): H386–97. https://doi.org/10.1152/ajpheart.1996.270.1.H386.Full Text Link to Item
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Mornev, O. A., O. V. Aslanidi, L. M. Chailakhian, and C. F. Starmer. “Splitting of the back edge of a propagating excitation pulse.” Biofizika 41, no. 1 (1996): 191–97.
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Mornev, O. A., O. V. Aslanidi, L. M. Chaĭlakhian, and C. H. F. Starmer. “[Splitting of the back edge of a propagating excitation pulse].” Biofizika 41, no. 1 (January 1996): 191–97.
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Starmer, C. F., and J. Starobin. “Spiral tip movement: The role of the action potential wavelength in polymorphic cardiac arrhythmias.” International Journal of Bifurcation and Chaos in Applied Sciences and Engineering 6, no. 10 (January 1, 1996): 1909–23. https://doi.org/10.1142/S0218127496001247.Full Text
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Dietz, M. A., C. Schlatter Ellis, and C. Frank Starmer. “Clock instability and its effect on time intervals in performance studies.” Cmg Proceedings 1 (December 1, 1995): 439–48.
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Starobin, J. M., Y. I. Zilberter, and C. F. Starmer. “Conditions for wavefront separation from an unexcitable obstacle in cardiac tissue of low excitability.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 17, no. 1 (December 1, 1995): 55–56.
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Spach, M. S., and C. F. Starmer. “Altering the topology of gap junctions a major therapeutic target for atrial fibrillation.” Cardiovascular Research 30, no. 3 (September 1995): 337–44. https://doi.org/10.1016/0008-6363(96)88514-2.Full Text
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Starmer, C. F., D. N. Romashko, R. S. Reddy, Y. I. Zilberter, J. Starobin, A. O. Grant, and V. I. Krinsky. “Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias.” Circulation 92, no. 3 (August 1995): 595–605. https://doi.org/10.1161/01.cir.92.3.595.Full Text
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Romashko, D. N., and C. F. Starmer. “Numerical experiments in a modified Beeler-Reuter cable model: Initiating fast (Na) and slow (Ca) waves.” Chaos, Solitons and Fractals 5, no. 3–4 (January 1, 1995): 417–24. https://doi.org/10.1016/0960-0779(93)E0033-8.Full Text
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Starobin, J. M., Y. I. Zilberter, and C. F. Starmer. “Unexcitable zones as a source of spiral waves initiation and cardiac arrhythmias.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 16, no. pt 1 (December 1, 1994): 5–6.
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Starmer, C. F. “Intellectual environment, technical resources and curiosity: elements for competitive research.” Indian Journal of Physiology and Pharmacology 38, no. 4 (October 1994): 233–37.
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Starmer, C. F., M. R. Reddy, A. Namasivayam, and M. Singh. “Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes.” Indian Journal of Physiology and Pharmacology 38, no. 4 (October 1994): 259–66.
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Gómez-Gesteria, M., G. Fernández-García, A. P. Muñuzuri, V. Pérez-Muñuzuri, V. I. Krinsky, C. F. Starmer, and V. Pérez-Villar. “Vulnerability in excitable Belousov-Zhabotinsky medium: from 1D to 2D.” Physica D: Nonlinear Phenomena 76, no. 4 (September 15, 1994): 359–68. https://doi.org/10.1016/0167-2789(94)90044-2.Full Text
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Whalley, D. W., D. J. Wendt, C. F. Starmer, Y. Rudy, and A. O. Grant. “Voltage-independent effects of extracellular K+ on the Na+ current and phase 0 of the action potential in isolated cardiac myocytes.” Circ Res 75, no. 3 (September 1994): 491–502. https://doi.org/10.1161/01.res.75.3.491.Full Text Link to Item
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Zilberter YuI, T. A., C. F. Starmer, J. Starobin, and A. O. Grant. “Late Na channels in cardiac cells: the physiological role of background Na channels.” Biophysical Journal 67, no. 1 (July 1994): 153–60. https://doi.org/10.1016/s0006-3495(94)80464-3.Full Text
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Zilberter, Y. I., C. F. Starmer, and A. O. Grant. “Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine.” Am J Physiol 266, no. 5 Pt 2 (May 1994): H2007–17. https://doi.org/10.1152/ajpheart.1994.266.5.H2007.Full Text Link to Item
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Nesterenko, V. V., E. P. Anyukhovsky, E. M. Bugrij, C. F. Starmer, G. G. Beloshapko, J. C. Makielski, A. V. Kuzmin, A. V. Menshikov MJu, A. V. Mazaev, and L. V. Rosenshtraukh. “Combination ethacizin and ethmozin treatment of resistant ventricular ectopy: theoretical, experimental, and clinical study.” Journal of Cardiovascular Pharmacology 23, no. 3 (March 1994): 501–8.
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Starobin, J., Y. I. Zilberter, and C. F. Starmer. “Vulnerability in one-dimensional excitable media.” Physica D: Nonlinear Phenomena 70, no. 4 (February 15, 1994): 321–41. https://doi.org/10.1016/0167-2789(94)90069-8.Full Text
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Grant, A. O., D. J. Wendt, Y. Zilberter, and C. F. Starmer. “Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials.” J Membr Biol 136, no. 2 (November 1993): 199–214. https://doi.org/10.1007/BF02505764.Full Text Link to Item
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Starmer, C. F., V. N. Biktashev, D. N. Romashko, M. R. Stepanov, O. N. Makarova, and V. I. Krinsky. “Vulnerability in an excitable medium: analytical and numerical studies of initiating unidirectional propagation.” Biophysical Journal 65, no. 5 (November 1993): 1775–87. https://doi.org/10.1016/s0006-3495(93)81233-5.Full Text
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Wendt, D. J., C. F. Starmer, and A. O. Grant. “pH dependence of kinetics and steady-state block of cardiac sodium channels by lidocaine.” Am J Physiol 264, no. 5 Pt 2 (May 1993): H1588–98. https://doi.org/10.1152/ajpheart.1993.264.5.H1588.Full Text Link to Item
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Spach, M. S., J. F. Heidlage, E. R. Darken, E. Hofer, K. H. Raines, and C. F. Starmer. “Cellular Vmax reflects both membrane properties and the load presented by adjoining cells.” The American Journal of Physiology 263, no. 6 Pt 2 (December 1992): H1855–63. https://doi.org/10.1152/ajpheart.1992.263.6.h1855.Full Text
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Wendt, D. J., C. F. Starmer, and A. O. Grant. “Na channel kinetics remain stable during perforated-patch recordings.” Am J Physiol 263, no. 6 Pt 1 (December 1992): C1234–40. https://doi.org/10.1152/ajpcell.1992.263.6.C1234.Full Text Link to Item
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Barber, M. J., D. J. Wendt, C. F. Starmer, and A. O. Grant. “Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs.” J Clin Invest 90, no. 2 (August 1992): 368–81. https://doi.org/10.1172/JCI115871.Full Text Link to Item
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Wendt, D. J., C. F. Starmer, and A. O. Grant. “Kinetics of interaction of the lidocaine metabolite glycylxylidide with the cardiac sodium channel. Additive blockade with lidocaine.” Circ Res 70, no. 6 (June 1992): 1254–73. https://doi.org/10.1161/01.res.70.6.1254.Full Text Link to Item
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Nesterenko, V. V., A. A. Lastra, L. V. Rosenshtraukh, and C. F. Starmer. “A proarrhythmic response to sodium channel blockade: modulation of the vulnerable period in guinea pig ventricular myocardium.” Journal of Cardiovascular Pharmacology 19, no. 5 (May 1992): 810–20.
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Starmer, C. F., A. R. Lancaster, A. A. Lastra, and A. O. Grant. “Cardiac instability amplified by use-dependent Na channel blockade.” Am J Physiol 262, no. 4 Pt 2 (April 1992): H1305–10. https://doi.org/10.1152/ajpheart.1992.262.4.H1305.Full Text Link to Item
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Starmer, C. F. “Frequency-dependent processes: a model for short-term memory.” Journal of Statistical Planning and Inference 33, no. 1 (January 1, 1992): 99–106. https://doi.org/10.1016/0378-3758(92)90095-A.Full Text
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Hurwitz, J. L., M. A. Dietz, C. F. Starmer, and A. O. Grant. “A source of bias in the analysis of single channel data: assessing the apparent interaction between channel proteins.” Comput Biomed Res 24, no. 6 (December 1991): 584–602. https://doi.org/10.1016/0010-4809(91)90042-u.Full Text Link to Item
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Schanne, O. F. “Steady state variables in the guarded receptor hypothesis.” The American Journal of Physiology 261, no. 6 Pt 2 (December 1991): H2098–2100. https://doi.org/10.1152/ajpheart.1991.261.6.h2098.Full Text
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Barber, M. J., C. F. Starmer, and A. O. Grant. “Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin. Evidence for two use-dependent binding sites.” Circ Res 69, no. 3 (September 1991): 677–96. https://doi.org/10.1161/01.res.69.3.677.Full Text Link to Item
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Starmer, C. F., A. A. Lastra, V. V. Nesterenko, and A. O. Grant. “Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments.” Circulation 84, no. 3 (September 1991): 1364–77. https://doi.org/10.1161/01.cir.84.3.1364.Full Text Link to Item
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Plonsey, R., C. F. Starmer, and I. Tipans. “The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.” Journal of Theoretical Biology 149, no. 1 (March 1991): 55–61. https://doi.org/10.1016/s0022-5193(05)80071-2.Full Text
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Nesterenko, V. V., E. P. Anyukhovsky, C. F. Starmer, G. G. Beloshapko, T. Ivanovoch, J. C. Makielski, E. M. Bugrij, A. V. Mazaev, and L. V. Rosenshtraukh. “Modulating intraventricular conduction through competition of two class 1 antiarrhythmic agents: experience with ethacizin and lidocaine in canine heart.” Journal of Molecular and Cellular Cardiology 23 Suppl 1 (February 1991): 115–24. https://doi.org/10.1016/0022-2828(91)90030-p.Full Text
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Starmer, C. F., V. V. Nesterenko, A. I. Undrovinas, A. O. Grant, and L. V. Rosenshtraukh. “Lidocaine blockade of continuously and transiently accessible sites in cardiac sodium channels.” J Mol Cell Cardiol 23 Suppl 1 (February 1991): 73–83. https://doi.org/10.1016/0022-2828(91)90026-i.Full Text Link to Item
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Colatsky, T. J., C. H. Follmer, and C. F. Starmer. “Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias.” Circulation 82, no. 6 (December 1990): 2235–42. https://doi.org/10.1161/01.cir.82.6.2235.Full Text
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Wang, A., M. A. Dietz, and C. F. Starmer. “Visualization tools for biomedical research.” Proceedings of the First Conference on Visualization in Biomedical Computing, December 1, 1990, 311–17.
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Undrovinas, A. I., N. Burnashev, D. Eroshenko, I. Fleidervish, C. F. Starmer, J. C. Makielski, and L. V. Rosenshtraukh. “Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart.” The American Journal of Physiology 259, no. 5 Pt 2 (November 1990): H1609–12. https://doi.org/10.1152/ajpheart.1990.259.5.h1609.Full Text
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Gilliam, F. R., P. A. Rivas, D. J. Wendt, C. F. Starmer, and A. O. Grant. “Extracellular pH modulates block of both sodium and calcium channels by nicardipine.” Am J Physiol 259, no. 4 Pt 2 (October 1990): H1178–84. https://doi.org/10.1152/ajpheart.1990.259.4.H1178.Full Text Link to Item
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Starmer, C. F., V. V. Nesterenko, F. R. Gilliam, and A. O. Grant. “Use of ionic currents to identify and estimate parameters in models of channel blockade.” Am J Physiol 259, no. 2 Pt 2 (August 1990): H626–34. https://doi.org/10.1152/ajpheart.1990.259.2.H626.Full Text Link to Item
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Starmer, C. F., and M. A. Dietz. “Managing clinical research data: software tools for hypothesis exploration.” Environmental Health Perspectives 87 (July 1990): 5–11. https://doi.org/10.1289/ehp.90875.Full Text
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Makielski, J. C., V. V. Nesterenko, W. L. Nelson, A. I. Undrovinas, C. F. Starmer, and L. V. Rosenshtraukh. “State dependence of ethacizin and ethmozin block of sodium current in voltage clamped and internally perfused cardiac Purkinje cells.” The Journal of Pharmacology and Experimental Therapeutics 253, no. 3 (June 1990): 1110–17.
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Nesterenko, V. V., E. P. Aniukhovskiĭ, Ch F. Starmer, G. G. Beloshapko, T. Ivanovich, E. M. Bugriĭ, A. V. Mazaev, and L. V. Rozenshtraukh. “[The combined effect of 2 first-line anti-arrhythmia drugs on the conduction velocity of myocardial stimulation].” Kardiologiia 30, no. 3 (March 1990): 81–87.
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Nesterenko, V. V., E. P. Aniukhovskiǐ, C. F. Starmer, G. G. Beloshapko, T. Ivanovich, E. M. Bugriǐ, A. V. Mazaev, and L. V. Rozenshtraukh. “The combined effect of 2 first-line anti-arrhythmia drugs on the conduction velocity of myocardial stimulation.” Kardiologiya 30, no. 3 (March 1, 1990): 81–87.
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Dietz, M. A., A. O. Grant, and C. F. Starmer. “An object oriented user interface for analysis of biological data.” Comput Biomed Res 23, no. 1 (February 1990): 82–96. https://doi.org/10.1016/0010-4809(90)90008-z.Full Text Link to Item
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Nesterenko, V. V., E. P. Aniukhovskiǐ, C. F. Starmer, G. G. Beloshapko, T. Ivanovich, E. M. Bugriǐ, A. V. Mazaev, and L. V. Rozenshtraukh. “The combined effect of 2 first-line anti-arrhythmia drugs on the conduction velocity of myocardial stimulation.” Kardiologiya 30, no. 3 (1990): 81–87.
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Starmer, C. F., A. I. Undrovinas, F. Scamps, G. Vassort, V. V. Nesterenko, and L. V. Rosenshtraukh. “Ethacizin blockade of calcium channels: A test of the guarded receptor hypothesis.” American Journal of Physiology Heart and Circulatory Physiology 257, no. 5 (December 14, 1989).
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Ware, R. E., R. M. Scearce, M. A. Dietz, C. F. Starmer, T. J. Palker, and B. F. Haynes. “Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.” J Immunol 143, no. 11 (December 1, 1989): 3632–40.Link to Item
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Grant, A. O., M. A. Dietz, F. R. Gilliam, and C. F. Starmer. “Blockade of cardiac sodium channels by lidocaine. Single-channel analysis.” Circ Res 65, no. 5 (November 1989): 1247–62. https://doi.org/10.1161/01.res.65.5.1247.Full Text Link to Item
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Starmer, C. F., A. I. Undrovinas, F. Scamps, G. Vassort, V. V. Nesterenko, and L. V. Rosenshtraukh. “Ethacizin blockade of calcium channels: a test of the guarded receptor hypothesis.” The American Journal of Physiology 257, no. 5 Pt 2 (November 1989): H1693–1704. https://doi.org/10.1152/ajpheart.1989.257.5.h1693.Full Text
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Whitcomb, D. C., F. R. Gilliam, C. F. Starmer, and A. O. Grant. “Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine.” J Clin Invest 84, no. 5 (November 1989): 1629–36. https://doi.org/10.1172/JCI114340.Full Text Link to Item
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Gilliam, F. R., C. F. Starmer, and A. O. Grant. “Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking.” Circ Res 65, no. 3 (September 1989): 723–39. https://doi.org/10.1161/01.res.65.3.723.Full Text Link to Item
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Packer, D. L., A. O. Grant, H. C. Strauss, and C. F. Starmer. “Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers.” J Clin Invest 83, no. 6 (June 1989): 2109–19. https://doi.org/10.1172/JCI114124.Full Text Link to Item
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Starmer, C. F. “Characterizing activity-dependent processes with a piecewise exponential model.” Mathematical and Computer Modelling 12, no. 9 (January 1, 1989): 1189. https://doi.org/10.1016/0895-7177(89)90273-2.Full Text
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Lastra, A. A., and C. F. Starmer. “POET: A tool for the analysis of the performance of parallel algorithms.” Proceedings of the International Conference on Parallel Processing 1 (December 1, 1988): 126–29.
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Starmer, C. F. “Characterizing activity-dependent processes with a piecewise exponential model.” Biometrics 44, no. 2 (June 1988): 549–59. https://doi.org/10.2307/2531867.Full Text
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Starmer, C. F. “CHARACTERIZING SYNAPTIC PLASTICITY WITH AN ACTIVITY DEPENDENT MODEL.,” December 1, 1987.
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Starmer, C. F. “Theoretical characterization of ion channel blockade. Competitive binding to periodically accessible receptors.” Biophysical Journal 52, no. 3 (September 1987): 405–12. https://doi.org/10.1016/s0006-3495(87)83229-0.Full Text
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Grant, A. O., and C. F. Starmer. “Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis.” Circ Res 60, no. 6 (June 1987): 897–913. https://doi.org/10.1161/01.res.60.6.897.Full Text Link to Item
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Starmer, C. F., D. J. Cherveny, M. A. Dietz, and J. M. Smaltz. “Managing research data with self-documenting files.” Computers and Biomedical Research, an International Journal 20, no. 3 (June 1987): 264–78. https://doi.org/10.1016/0010-4809(87)90058-9.Full Text
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Starmer, C. F., D. L. Packer, and A. O. Grant. “Ligand binding to transiently accessible sites: mechanisms for varying apparent binding rates.” J Theor Biol 124, no. 3 (February 7, 1987): 335–41. https://doi.org/10.1016/s0022-5193(87)80120-0.Full Text Link to Item
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Starmer, C. F., and K. R. Courtney. “Modeling ion channel blockade at guarded binding sites: application to tertiary drugs.” The American Journal of Physiology 251, no. 4 Pt 2 (October 1986): H848–56. https://doi.org/10.1152/ajpheart.1986.251.4.h848.Full Text
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Moorman, J. R., R. Yee, T. Bjornsson, C. F. Starmer, A. O. Grant, and H. C. Strauss. “pKa does not predict pH potentiation of sodium channel blockade by lidocaine and W6211 in guinea pig ventricular myocardium.” The Journal of Pharmacology and Experimental Therapeutics 238, no. 1 (July 1986): 159–66.
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Starmer, C. F., J. Z. Yeh, and J. Tanguy. “A quantitative description of QX222 blockade of sodium channels in squid axons.” Biophysical Journal 49, no. 4 (April 1986): 913–20. https://doi.org/10.1016/s0006-3495(86)83719-5.Full Text
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Starmer, C. F. “Theoretical characterization of ion channel blockade: ligand binding to periodically accessible receptors.” Journal of Theoretical Biology 119, no. 2 (March 1986): 235–49. https://doi.org/10.1016/s0022-5193(86)80077-7.Full Text
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Starmer, C. F., M. A. Dietz, and A. O. Grant. “Signal discretization: a source of error in histograms of ion channel events.” Ieee Trans Biomed Eng 33, no. 1 (January 1986): 70–73. https://doi.org/10.1109/tbme.1986.325856.Full Text Link to Item
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Starmer, C. F., and A. O. Grant. “Phasic ion channel blockade. A kinetic model and parameter estimation procedure.” Mol Pharmacol 28, no. 4 (October 1985): 348–56.Link to Item
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Starmer, C. F., and R. B. Kerr. “Simulation of use-dependent uptake of ion channel blocking agents by excitable membranes.” Ieee Transactions on Bio Medical Engineering 32, no. 10 (October 1985): 770–74. https://doi.org/10.1109/tbme.1985.325492.Full Text
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Starmer, C. F., and M. D. Hollett. “Mechanisms of apparent affinity variation of guarded receptors.” Journal of Theoretical Biology 115, no. 3 (August 1985): 337–49. https://doi.org/10.1016/s0022-5193(85)80196-x.Full Text
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Broughton, A., A. O. Grant, C. F. Starmer, J. K. Klinger, B. S. Stambler, and H. C. Strauss. “Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium.” Circ Res 55, no. 4 (October 1984): 513–23. https://doi.org/10.1161/01.res.55.4.513.Full Text Link to Item
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Grant, A. O., C. F. Starmer, and H. C. Strauss. “Antiarrhythmic drug action. Blockade of the inward sodium current.” Circ Res 55, no. 4 (October 1984): 427–39. https://doi.org/10.1161/01.res.55.4.427.Full Text Link to Item
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Linfors, E. W., J. R. Feussner, C. L. Blessing, C. F. Starmer, F. A. Neelon, and P. A. McKee. “Spurious hypertension in the obese patient. Effect of sphygmomanometer cuff size on prevalence of hypertension.” Arch Intern Med 144, no. 7 (July 1984): 1482–85.Link to Item
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Starmer, C. F., A. O. Grant, and H. C. Strauss. “Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.” Biophys J 46, no. 1 (July 1984): 15–27. https://doi.org/10.1016/S0006-3495(84)83994-6.Full Text Link to Item
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Wenger, T. L., S. Lederman, C. F. Starmer, T. Brown, and H. C. Strauss. “A method for quantitating antifibrillatory effects of drugs after coronary reperfusion in dogs: improved outcome with bretylium.” Circulation 69, no. 1 (January 1984): 142–48. https://doi.org/10.1161/01.cir.69.1.142.Full Text
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Grant, A. O., C. F. Starmer, and H. C. Strauss. “Unitary sodium channels in isolated cardiac myocytes of rabbit.” Circ Res 53, no. 6 (December 1983): 823–29. https://doi.org/10.1161/01.res.53.6.823.Full Text Link to Item
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Hla, K. M., J. R. Feussner, C. L. Blessing-Feussner, F. A. Neelon, E. W. Linfors, C. F. Starmer, and P. A. McKee. “BP control. Improvement in a university medical clinic by use of a physician's associate.” Arch Intern Med 143, no. 5 (May 1983): 920–23. https://doi.org/10.1001/archinte.143.5.920.Full Text Link to Item
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Bowyer, K. W., and C. F. Starmer. “Optimizing Contiguous-Element Region Selection for Virtual Memory Systems.” Ieee Transactions on Computers C–32, no. 12 (January 1, 1983): 1201–3. https://doi.org/10.1109/TC.1983.1676185.Full Text
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Beck, J. W., R. J. Jaszczak, and C. F. Starmer. “ANALYSIS OF SPECT USING MONTE CARLO SIMULATION.” Proceedings of Spie the International Society for Optical Engineering 372 (December 1, 1982): 32–38.
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Bowyer, K. W., F. Starmer, and P. DuBois. “Error sensitivity of computerized tomography guided stereotaxis.” Computers and Biomedical Research, an International Journal 15, no. 3 (June 1982): 272–80. https://doi.org/10.1016/0010-4809(82)90062-3.Full Text
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Starmer, C. F., and K. L. Lee. “A data-based approach to assessing clinical interventions in the setting of chronic disease.” Cancer Treat Rep 66, no. 5 (May 1982): 1077–82.Link to Item
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Bowyer, K. W., and C. F. Starmer. “A simulation-based sensitivity study of radionuclide angiocardiographic approaches to shunt assessment.” Computers and Biomedical Research, an International Journal 15, no. 2 (April 1982): 111–28. https://doi.org/10.1016/0010-4809(82)90031-3.Full Text
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Starmer, C. F. “A recursively interpreted data structure for representing clinical entities.” Journal of Medical Systems 6, no. 2 (April 1982): 183–96. https://doi.org/10.1007/bf00997052.Full Text
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Beck, J. W., R. J. Jaszczak, R. Edward Coleman, C. Frank Starmer, and L. W. Nolte. “Analysis of spect including scatter and attenuation using sophisticated monte carlo modeling methods.” Ieee Transactions on Nuclear Science 29, no. 1 (January 1, 1982): 506–11. https://doi.org/10.1109/TNS.1982.4335896.Full Text
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Starmer, C. F., D. A. H. Smith, J. S. Wells, and B. C. Wright. “PROBLEMS IN DATA MANAGEMENT WHEN STUDYING CHRONIC ILLNESS.” Proceedings of the Hawaii International Conference on System Science, December 1, 1981, 144–51.
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Feussner, J. R., E. W. Linfors, C. L. Blessing, and C. F. Starmer. “Computed tomography brain scanning in alcohol withdrawal seizures. Value of the neurologic examination.” Annals of Internal Medicine 94, no. 4 pt 1 (April 1981): 519–22. https://doi.org/10.7326/0003-4819-94-4-519.Full Text
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Beck, J. W., R. J. Jaszczak, R. E. Coleman, C. F. Starmer, and L. W. Nolte. “ANALYSIS OF SPECT INCLUDING SCATTER AND ATTENUATION USING SOPHISTICATED MONTE CARLO MODELING METHODS.” Ieee Transactions on Nuclear Science NS-29, no. 1 (1981): 506–11.
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Starmer, C. F., D. A. Smith, J. S. Wells, and B. C. Wright. “Problems in data management when studying chronic illness.” Journal of Medical Systems 5, no. 4 (January 1981): 271–80. https://doi.org/10.1007/bf02222145.Full Text
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Starmer, C. F., K. L. Lee, F. E. Harrell, and R. A. Rosati. “On the complexity of investigating chronic illness.” Biometrics 36, no. 2 (June 1980): 333–35.Link to Item
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Lee, K. L., J. F. McNeer, C. F. Starmer, P. J. Harris, and R. A. Rosati. “Clinical judgment and statistics. Lessons from a simulated randomized trial in coronary artery disease.” Circulation 61, no. 3 (March 1980): 508–15. https://doi.org/10.1161/01.cir.61.3.508.Full Text Link to Item
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Starmer, C. F., K. L. Lee, F. E. Harrell, and R. A. Rosati. “DATABASE APPROACH FOR STABILIZING CLINICAL DECISIONS IN THE SETTING OF CHRONIC ILLNESS.” Institution of Mechanical Engineers, Conference Publications, January 1, 1979, 777–86.
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Smith, W. M., and C. F. Starmer. “Error propagation in quantitative biplane cineroentgenography.” Physics in Medicine and Biology 23, no. 4 (July 1978): 677–85. https://doi.org/10.1088/0031-9155/23/4/009.Full Text
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Ideker, R. E., V. S. Behar, G. S. Wagner, J. W. Starr, C. F. Starmer, K. L. Lee, and D. B. Hackel. “Evaluation of asynergy as an indicator of myocardial fibrosis.” Circulation 57, no. 4 (April 1978): 715–25. https://doi.org/10.1161/01.cir.57.4.715.Full Text Link to Item
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Starmer, C. E. “Laboratory for development of health information system.” Abstracts of Hospital Management Studies 14, no. 3 (January 1, 1978).
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Moses, M. J., G. H. Slatton, T. M. Gambling, and C. F. Starmer. “Synaptonemal complex karyotyping in spermatocytes of the Chinese hamster (Cricetulus griseus). III. Quantitative evaluation.” Chromosoma 60, no. 4 (April 1977): 345–75. https://doi.org/10.1007/bf00292859.Full Text
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Roe, C. R., C. F. Starmer, and F. R. Cobb. “Mathematical modifications fail to improve CPK estimates of extent of infarct.” Circulation 55, no. 4 (April 1977): 678–79. https://doi.org/10.1161/01.cir.55.4.678.Full Text
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Roe, C. R., F. R. Cobb, and C. F. Starmer. “The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion.” Circulation 55, no. 3 (March 1977): 438–49. https://doi.org/10.1161/01.cir.55.3.438.Full Text
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Starmer, C. F., and R. A. Rosati. “A DSS for management of patients with a chronic illness.” Acm Sigmis Database 8, no. 3 (January 1, 1977): 51–57. https://doi.org/10.1145/1017583.1017596.Full Text
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Starmer, C. F., and K. L. Lee. “A mathematical approach to medical decisions: application of Bayes' rule to a mixture of continuous and discrete clinical variables.” Comput Biomed Res 9, no. 6 (December 1976): 531–41. https://doi.org/10.1016/0010-4809(76)90012-4.Full Text Link to Item
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Smith, W. M., and C. F. Starmer. “Computer representation of coronary arterial trees.” Computers and Biomedical Research, an International Journal 9, no. 2 (April 1976): 187–201. https://doi.org/10.1016/0010-4809(76)90042-2.Full Text
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Margolis, J. R., J. W. Hirshfeld, J. F. McNeer, C. F. Starmer, R. A. Rosati, R. H. Peter, V. S. Behar, and Y. Kong. “Sudden death due to coronary artery disease. A clinical, hemodynamic, and angiographic profile.” Circulation 52, no. 6 Suppl (December 1975): III180–88.Link to Item
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Rosati, R. A., J. F. McNeer, C. F. Starmer, B. S. Mittler, J. J. Morris, and A. G. Wallace. “A new information system for medical practice.” Archives of Internal Medicine 135, no. 8 (August 1975): 1017–24. https://doi.org/10.1001/archinte.1975.00330080019003.Full Text
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Roe, C. R., and C. F. Starmer. “A sensitivity analysis of enzymatic estimation of infarct size.” Circulation 52, no. 1 (July 1975): 1–5. https://doi.org/10.1161/01.cir.52.1.1.Full Text
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McNeer, J. F., A. G. Wallace, G. S. Wagner, C. F. Starmer, and R. A. Rosati. “The course of acute myocardial infarction. Feasibility of early discharge of the uncomplicated patient.” Circulation 51, no. 3 (March 1975): 410–13. https://doi.org/10.1161/01.cir.51.3.410.Full Text
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Frank Starmer, C., O. Sperling, and J. B. Wyngaarden. “A kinetic model for the intramolecular distribution of 15N in uric acid in patients with primary gout fed 15N-glycine.” Mathematical Biosciences 25, no. 1–2 (January 1, 1975): 105–23. https://doi.org/10.1016/0025-5564(75)90055-3.Full Text
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Starmer, C. F., and R. A. Rosati. “Computer-based aid to managing patients with illness chronic.” Computer 8, no. 1 (January 1, 1975): 46–50. https://doi.org/10.1109/C-M.1975.218755.Full Text
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Starmer, C. F., and W. M. Smith. “Problems in Acquisition and Representation of Coronary Arterial Trees.” Computer 8, no. 7 (January 1, 1975): 36–41. https://doi.org/10.1109/C-M.1975.219023.Full Text
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Starmer, C. F., and W. M. Smith. “Computer storage and retrieval of coronary trees.” Proc.Soc.Photo Opt.Instr.Engin. Vol.72 (January 1, 1975): 195–99.
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Starmer, C. F., and W. M. Smith. “COMPUTER STORAGE AND RETRIEVAL OF CORONARY TREES.” Spie Semin Proc 72 (January 1, 1975): 195–99.
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McNeer, J. F., M. J. Conley, C. F. Starmer, V. S. Behar, Y. Kong, R. H. Peter, A. G. Bartel, et al. “Complete and incomplete revascularization at aortocoronary bypass surgery: experience with 392 consecutive patients.” Am Heart J 88, no. 2 (August 1974): 176–82. https://doi.org/10.1016/0002-8703(74)90007-6.Full Text Link to Item
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Starmer, C. F., R. A. Rosati, and J. F. McNeer. “A comparison of frequency distributions for use in a model for selecting treatment in coronary artery disease.” Computers and Biomedical Research, an International Journal 7, no. 3 (June 1974): 278–93. https://doi.org/10.1016/0010-4809(74)90007-x.Full Text
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McNeer, J. F., C. F. Starmer, A. G. Bartel, V. S. Behar, Y. Kong, R. H. Peter, and R. A. Rosati. “The nature of treatment selection in coronary artery disease. Experience with medical and surgical treatment of a chronic disease.” Circulation 49, no. 4 (April 1974): 606–14. https://doi.org/10.1161/01.cir.49.4.606.Full Text Link to Item
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Starmer, C. F., R. A. Rosati, and J. F. McNeer. “Editorial: Data bank use in management of chronic disease.” Computers and Biomedical Research, an International Journal 7, no. 2 (April 1974): 111–16. https://doi.org/10.1016/0010-4809(74)90016-0.Full Text
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Sperling, O., J. B. Wyngaarden, and C. F. Starmer. “The kinetics of intramolecular distribution of 15N in uric acid following administration of 15N-glycine: preferential labeling of N-(3+9) of uric acid in primary gout and a reappraisal of the "glutamine hypothesis".” Advances in Experimental Medicine and Biology 41 (January 1974): 371–93. https://doi.org/10.1007/978-1-4757-1433-3_1.Full Text
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Starmer, C. F., J. E. Grizzle, and P. K. Sen. “Comment.” Journal of the American Statistical Association 69, no. 346 (January 1, 1974): 376–78. https://doi.org/10.1080/01621459.1974.10482958.Full Text
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Starmer, C. F., and W. M. Smith. “PROBLEMS IN ACQUISITION AND REPRESENTATION OF CORONARY ARTERIAL TRESS.,” January 1, 1974, 143–47.
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Sperling, O., J. B. Wyngaarden, and C. F. Starmer. “The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout.” The Journal of Clinical Investigation 52, no. 10 (October 1973): 2468–85. https://doi.org/10.1172/jci107438.Full Text
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Starmer, C. F., P. A. McHale, F. R. Cobb, and J. C. Greenfield. “Evaluation of several methods for computing stroke volume from central aortic pressure.” Circulation Research 33, no. 2 (August 1973): 139–48. https://doi.org/10.1161/01.res.33.2.139.Full Text
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Davidson, R. M., B. W. Ramo, A. G. Wallace, R. E. Whalen, and C. F. Starmer. “Blood-gas and hemodynamic responses to oxygen in acute myocardial infarction.” Circulation 47, no. 4 (April 1973): 704–11. https://doi.org/10.1161/01.cir.47.4.704.Full Text
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Starmer, C. F., and R. E. Whalen. “Current density and electrically induced ventricular fibrillation.” Medical Instrumentation 7, no. 2 (March 1973): 158–61.
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Starmer, C. F., P. A. McHale, and J. C. Greenfield. “Processing of arterial pressure waves with a digital computer.” Computers and Biomedical Research, an International Journal 6, no. 1 (February 1973): 90–96. https://doi.org/10.1016/0010-4809(73)90064-5.Full Text
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Starmer, C. F., and R. E. Whalen. “Current density and electrically induced ventricular fibrillation.” Med Instrum 7, no. 1 (January 1973): 3–6.Link to Item
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Starmer, C. F., and R. E. Whalen. “Current density and electrically induced ventricular fibrillation.” Medical Instrumentation 7, no. 1 (January 1973): 3–6.
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Wyngaarden, J. B., O. Sperling, and F. Starmer. “A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout.” Transactions of the American Clinical and Climatological Association 84 (January 1973): 166–82.
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Starmer, C. F. “A nonparametric general linear model.” Computers and Biomedical Research, an International Journal 5, no. 6 (December 1972): 608–12. https://doi.org/10.1016/0010-4809(72)90040-7.Full Text
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Starmer, C. F., R. A. Rosati, and S. B. Simon. “Interactive acquisition and analysis of discrete data.” Computers and Biomedical Research, an International Journal 5, no. 5 (October 1972): 505–14. https://doi.org/10.1016/0010-4809(72)90057-2.Full Text
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Starmer, C. F., and R. E. Whalen. “Fibrillatory current thresholds & standards.” Health Devices 1, no. 10 (June 1972): 221.
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Greenfield, J. C., C. F. Starmer, and A. Walston. “Measurement of aortic blood flow in man by the computed pressure derivative method.” Journal of Applied Physiology 31, no. 5 (November 1971): 792–95. https://doi.org/10.1152/jappl.1971.31.5.792.Full Text
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Beaumont, J. O., W. A. Radke, J. Trotter, N. Palley, D. Erbeck, H. Shubin, R. A. Rosati, et al. “SAN DIEGO BIOMEDICAL SYMPOSIUM, 1971, PROCEEDINGS, v 10.,” January 1, 1971.
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Starmer, C. F., H. D. McIntosh, and R. E. Whalen. “Electrical hazards and cardiovascular function.” The New England Journal of Medicine 284, no. 4 (January 1971): 181–86. https://doi.org/10.1056/nejm197101282840405.Full Text
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Ramo, B. W., N. Myers, A. G. Wallace, F. Starmer, D. O. Clark, and R. E. Whalen. “Hemodynamic findings in 123 patients with acute myocardial infarction on admission.” Circulation 42, no. 4 (October 1970): 567–77. https://doi.org/10.1161/01.cir.42.4.567.Full Text
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Starmer, C. F., and D. O. Clark. “Computer computations of cardiac output using the gamma function.” Journal of Applied Physiology 28, no. 2 (February 1970): 219–20. https://doi.org/10.1152/jappl.1970.28.2.219.Full Text
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Grizzle, J. E., C. F. Starmer, and G. G. Koch. “Analysis of categorical data by linear models.” Biometrics 25, no. 3 (September 1969): 489–504. https://doi.org/10.2307/2528901.Full Text
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Harley, A., C. F. Starmer, and J. C. Greenfield. “Pressure-flow studies in man. An evaluation of the duration of the phases of systole.” The Journal of Clinical Investigation 48, no. 5 (May 1969): 895–905. https://doi.org/10.1172/jci106048.Full Text
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Whalen, R. E., and C. F. Starmer. “Electric shock hazards in clinical cardiology.” Modern Concepts of Cardiovascular Disease 36, no. 2 (February 1967): 7–12.
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McIntosh, H. D., F. Starmer, and R. E. Whalen. “A comparison of the electrical ventricular fibrillation threshold with and without anesthesia.” American Heart Journal 72, no. 3 (September 1966): 419–20. https://doi.org/10.1016/s0002-8703(66)80016-9.Full Text
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Starmer, C. F., R. E. Whalen, and H. D. McIntosh. “Determination of leakage currents in medical equipment.” The American Journal of Cardiology 17, no. 3 (March 1966): 437–38. https://doi.org/10.1016/0002-9149(66)90228-1.Full Text
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Barry, W. F., C. F. Starmer, R. E. Whalen, and H. D. McIntosh. “Electric shock hazards in radiology departments.” The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine 95, no. 4 (December 1965): 976–80. https://doi.org/10.2214/ajr.95.4.976.Full Text
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Pilkington, T. C., C. F. Starmer, and J. P. Boineau. “Letter to the Editor: on the electrocardiographic field equation.” The Bulletin of Mathematical Biophysics 27, no. 4 (December 1965): 493–95. https://doi.org/10.1007/bf02476852.Full Text
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STARMER, C. F., R. E. WHALEN, and H. D. MCINTOSH. “HAZARDS OF ELECTRIC SHOCK IN CARDIOLOGY.” The American Journal of Cardiology 14 (October 1964): 537–46. https://doi.org/10.1016/0002-9149(64)90039-6.Full Text
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THOMPSON, H. K., C. F. STARMER, R. E. WHALEN, and H. D. MCINTOSH. “INDICATOR TRANSIT TIME CONSIDERED AS A GAMMA VARIATE.” Circulation Research 14 (June 1964): 502–15. https://doi.org/10.1161/01.res.14.6.502.Full Text
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WHALEN, R. E., C. F. STARMER, and H. D. MCINTOSH. “ELECTRICAL HAZARDS ASSOCIATED WITH CARDIAC PACEMAKING.” Annals of the New York Academy of Sciences 111 (June 1964): 922–31. https://doi.org/10.1111/j.1749-6632.1964.tb53162.x.Full Text
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Conference Papers
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Gupta, S., H. C. Liaw, P. Vadakkepat, and C. F. Starmer. “Smartphone spectrophotometer for point-of-care diagnostics in low-resource settings.” In Ieee Region 10 Humanitarian Technology Conference, R10 Htc 2015 Co Located With 8th International Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment and Management, Hnicem 2015, 2016. https://doi.org/10.1109/R10-HTC.2015.7391866.Full Text
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Starmer, C. F. “FEEDBACK STABILIZATION OF CONTROL POLICY SELECTION IN DATA/KNOWLEDGE BASED SYSTEMS.,” 586–91, 1984.
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