J. Franklin Wharam
Professor of Medicine
Dr. Frank Wharam is a general internist and health policy researcher. He studies the impact of national and state policies on the health of large populations, chronically ill patients, and vulnerable subgroups. His research often examines effects of health insurance benefit designs such as value-based, consumer-directed (CDHPs), and high-deductible health plans (HDHPs). He has led many large-scale studies in these areas, funded by the National Institutes of Health, the Centers for Disease Control and Prevention, and the Patient-centered Outcomes Research Institute. Dr. Wharam is a leading scholar in research about HDHPs and cost sharing. He also focuses on interventions that affect people with diabetes, substance use disorders, cancer, obesity, mental illness, and respiratory diseases. He has expertise in rigorous quasi-experiment research designs, causal inference in observational data, and large claims data analyses. His work has been published in journals such as Annals of Internal Medicine, JAMA, the New England Journal of Medicine, and Health Affairs. He is the national co-chair of the Natural Experiments in Diabetes Translation (NEXT-D3) research collaborative.
Dr. Wharam is Professor of Medicine in the Division of General Internal Medicine and a core faculty member in the Margolis Center. He directs a new center devoted to analyzing large-scale health policy effects in order to inform a more efficient and equitable health care system. He also cares for patients at the Duke Outpatient Clinic.
Dr. Wharam joined Duke after 17 years at the Harvard Medical School Department of Population Medicine. There he held the Martin Robison Delany endowed chair and was Director of the Division of Health Policy and Insurance Research. Before Harvard, he completed Internal Medicine residency at Duke in 2004.
Current Research Interests
Dr. Frank Wharam is a general internist and health policy researcher. He studies the impact of national and state policies on the health outcomes of chronically ill and vulnerable populations. His research often examines effects of health insurance benefit designs such as value-based, consumer-directed, and high-deductible health plans. Dr. Wharam also focuses on interventions that affect people with substance use disorders, diabetes, obesity, mental illness, and respiratory diseases. Other interests include the adverse effects of wasteful health care spending on medical and non-medical outcomes. He has expertise in rigorous quasi-experiment research designs, causal inference in observational data, and large claims data analyses.
Current Appointments & Affiliations
- Professor of Medicine, Medicine, General Internal Medicine, Medicine 2022
- Core Faculty Member, Duke-Margolis Center for Health Policy, Duke - Margolis Center For Health Policy, Initiatives 2021
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2022
Contact Information
- 710 West Main Street, Durham, NC 27710
- Dept of Med, Durham, NC 27710
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james.wharam@duke.edu
(919) 684-8111
- Background
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Education, Training, & Certifications
- Fellowship, Internal Medicine, Harvard Medical School 2004 - 2007
- Fellowship, Medical Ethics, Harvard Medical School 2005 - 2006
- Residency, Internal Medicine, Duke University 2001 - 2004
- M.B.B.Ch., University College Dublin (Ireland) 2001
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Medical Licensure
- 2021-02565. North Carolina. 2021
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Previous Appointments & Affiliations
- Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2021 - 2022
- Expertise
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Subject Headings
- Administrative Claims, Healthcare
- Bariatric Surgery
- Cancer
- Catastrophic health insurance
- Chronic Illness
- Consumer-driven health care
- Consumer-driven health insurance
- Deductibles (Insurance)
- Deductibles and Coinsurance
- Diabetes
- Diabetes Complications
- Health Disparities
- Health Equity
- Health Policy
- Health Services Accessibility
- Health Services Research
- Health insurance
- Health insurance claims
- Health insurance policies
- Health insurance--Government policy--United States
- Interrupted Time Series Analysis
- Mental illness
- Obesity
- Obesity Management
- Obesity--Surgery
- Research Design
- Statistical matching
- Substance abuse
- Value Based Care
- Vulnerable Populations
- Research
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Selected Grants
- Impact of high deductible health plans and COVID-19 on alcohol use disorder treatment access, outcomes, and disparities awarded by National Institutes of Health 2022 - 2026
- Impact of Medicare Part D opioid safety policies on disabled beneficiaries before and during the COVID-19 pandemic 2022 - 2026
- Long-term Impact of Reduced Patient Out-of-pocket Costs on Diabetes Complications (NEXT-D 3) - Yr 2 2021 - 2025
- A Naturalistic Experiment Evaluating the Impact of Medicaid Treatment Reimbursement Changes on Opioid Prescribing and Patient Outcomes Among Patients with Low Back Pain 2021 - 2023
- Oral Targeted Anticancer Medication Trends and Modifiable Use Predictors (OTAM) 2021 - 2023
- Clinical and Health Care Use Outcomes for Vertical Sleeve Gastrectomy vs. Roux-en-Y Gastric Bypass Using a National Commercial Insurance Claims Dataset 2021 - 2022
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Callaway Kim, Katherine, Stephanie Argetsinger, James Frank Wharam, Fang Zhang, David E. Arterburn, Adolfo Fernandez, Dennis Ross-Degnan, Jamie Wallace, and Kristina H. Lewis. “Acute Care Utilization and Costs Up to 4 Years After Index Sleeve Gastrectomy or Roux-en-Y Gastric Bypass: A National Claims-based Study.” Ann Surg 277, no. 1 (January 1, 2023): e78–86. https://doi.org/10.1097/SLA.0000000000004972.Full Text Link to Item
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Garvey, Katharine C., Jonathan A. Finkelstein, Fang Zhang, Robert LeCates, Lori Laffel, and James F. Wharam. “Health Care Utilization Trends Across the Transition Period in a National Cohort of Adolescents and Young Adults With Type 1 Diabetes.” Diabetes Care 45, no. 11 (November 1, 2022): 2509–17. https://doi.org/10.2337/dc22-0152.Full Text Link to Item
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Kutz, Alexander, Daniel Koch, Sebastian Haubitz, Antoinette Conca, Ciril Baechli, Katharina Regez, Claudia Gregoriano, et al. “Association of Interprofessional Discharge Planning Using an Electronic Health Record Tool With Hospital Length of Stay Among Patients with Multimorbidity: A Nonrandomized Controlled Trial.” Jama Netw Open 5, no. 9 (September 1, 2022): e2233667. https://doi.org/10.1001/jamanetworkopen.2022.33667.Full Text Link to Item
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Lewis, Kristina H., David E. Arterburn, Fang Zhang, Katherine Callaway, Jamie Wallace, Adolfo Fernandez, Dennis Ross-Degnan, and James F. Wharam. “Response to "Why Gastric Bypass Might Not be a Good Choice for Type-2 Diabetes Treatment".” Ann Surg 276, no. 2 (August 1, 2022): e138–39. https://doi.org/10.1097/SLA.0000000000005269.Full Text Link to Item
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Ma, Yanlei, Kenton J. Johnston, Hao Yu, J Frank Wharam, and Hefei Wen. “State Mandatory Paid Sick Leave Associated With A Decline In Emergency Department Use In The US, 2011-19.” Health Aff (Millwood) 41, no. 8 (August 2022): 1169–75. https://doi.org/10.1377/hlthaff.2022.00098.Full Text Link to Item
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Siegel, Karen R., Mohammed K. Ali, Ronald T. Ackermann, Bernard Black, Nathalie Huguet, Abel Kho, Carol M. Mangione, et al. “Evaluating Natural Experiments that Impact the Diabetes Epidemic: an Introduction to the NEXT-D3 Network.” Curr Diab Rep 22, no. 8 (August 2022): 393–403. https://doi.org/10.1007/s11892-022-01480-1.Full Text Link to Item
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Wharam, J Frank, Jamie Wallace, Stephanie Argetsinger, Fang Zhang, Christine Y. Lu, Tomasz P. Stryjewski, Dennis Ross-Degnan, and Joseph P. Newhouse. “Diabetes Microvascular Disease Diagnosis and Treatment After High-Deductible Health Plan Enrollment.” Diabetes Care 45, no. 8 (August 1, 2022): 1754–61. https://doi.org/10.2337/dc21-0407.Full Text Link to Item
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Sinaiko, Anna D., Ann Chen Wu, J Frank Wharam, and Alison A. Galbraith. “Reply to "When too much is too much".” J Allergy Clin Immunol Pract 10, no. 6 (June 2022): 1669–70. https://doi.org/10.1016/j.jaip.2022.02.046.Full Text Link to Item
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Lewis, Kristina H., Stephanie Argetsinger, David E. Arterburn, Jenna Clemenzi, Fang Zhang, Ronald Kamusiime, Adolfo Fernandez, Dennis Ross-Degnan, and James F. Wharam. “Comparison of Ambulatory Health Care Costs and Use Associated With Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.” Jama Netw Open 5, no. 5 (May 2, 2022): e229661. https://doi.org/10.1001/jamanetworkopen.2022.9661.Full Text Link to Item
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Ferrario, Alessandra, Fang Zhang, Dennis Ross-Degnan, J Frank Wharam, Martha L. Twaddle, and Anita K. Wagner. “Use of Palliative Care Among Commercially Insured Patients With Metastatic Cancer Between 2001 and 2016.” Jco Oncol Pract 18, no. 5 (May 2022): e677–87. https://doi.org/10.1200/OP.21.00516.Full Text Link to Item
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Lowry, Kathryn P., Katherine A. Callaway, Janie M. Lee, Fang Zhang, Dennis Ross-Degnan, J Frank Wharam, Karla Kerlikowske, et al. “Trends in Annual Surveillance Mammography Participation Among Breast Cancer Survivors From 2004 to 2016.” J Natl Compr Canc Netw 20, no. 4 (April 2022): 379-386.e9. https://doi.org/10.6004/jnccn.2021.7081.Full Text Link to Item
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Lu, Christine Y., Fang Zhang, Jamie Wallace, Robert F. LeCates, Alisa B. Busch, Jeanne Madden, Matthew Callahan, et al. “High-Deductible Health Plans Paired With Health Savings Accounts Increased Medication Cost Burden Among Individuals With Bipolar Disorder.” J Clin Psychiatry 83, no. 2 (March 9, 2022). https://doi.org/10.4088/JCP.20m13865.Full Text Link to Item
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Goldstein, A., and J. F. Wharam. ““Choose the Plan That’s Right for You”: Choice Devolution as Class-Biased Institutional Change in U.S. Employer-Sponsored Health Insurance.” Sociological Science 9 (January 1, 2022): 221–51. https://doi.org/10.15195/V9.A10.Full Text
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Sinaiko, Anna D., Marema Gaye, Ann Chen Wu, Elizabeth Bambury, Fang Zhang, Xin Xu, J Frank Wharam, and Alison A. Galbraith. “Out-of-Pocket Spending for Asthma-Related Care Among Commercially Insured Patients, 2004-2016.” J Allergy Clin Immunol Pract 9, no. 12 (December 2021): 4324-4331.e7. https://doi.org/10.1016/j.jaip.2021.07.054.Full Text Link to Item
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Garabedian, Laura F., Fang Zhang, Robert LeCates, Jamie Wallace, Dennis Ross-Degnan, and James F. Wharam. “Trends in high deductible health plan enrolment and spending among commercially insured members with and without chronic conditions: a Natural Experiment for Translation in Diabetes (NEXT-D2) Study.” Bmj Open 11, no. 9 (September 13, 2021): e044198. https://doi.org/10.1136/bmjopen-2020-044198.Full Text Link to Item
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Chou, Shih-Chuan, Arthur S. Hong, Scott G. Weiner, and J Frank Wharam. “Impact of High-Deductible Health Plans on Emergency Department Patients With Nonspecific Chest Pain and Their Subsequent Care.” Circulation 144, no. 5 (August 3, 2021): 336–49. https://doi.org/10.1161/CIRCULATIONAHA.120.052501.Full Text Link to Item
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Chou, Shih-Chuan, Arthur S. Hong, Scott G. Weiner, and J Frank Wharam. “High-deductible health plans and low-value imaging in the emergency department.” Health Serv Res 56, no. 4 (August 2021): 709–20. https://doi.org/10.1111/1475-6773.13569.Full Text Link to Item
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Galbraith, Alison A., Dennis Ross-Degnan, Fang Zhang, Ann Chen Wu, Anna Sinaiko, Alon Peltz, Xin Xu, Jamie Wallace, and J Frank Wharam. “Controller Medication Use and Exacerbations for Children and Adults With Asthma in High-Deductible Health Plans.” Jama Pediatr 175, no. 8 (August 1, 2021): 807–16. https://doi.org/10.1001/jamapediatrics.2021.0747.Full Text Link to Item
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Lu, Christine Y., Alisa B. Busch, Fang Zhang, Jeanne M. Madden, Matthew X. Callahan, Robert F. LeCates, Jamie Wallace, et al. “Impact of High-Deductible Health Plans on Medication Use Among Individuals With Bipolar Disorder.” Psychiatr Serv 72, no. 8 (August 1, 2021): 926–34. https://doi.org/10.1176/appi.ps.202000362.Full Text Link to Item
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Galbraith, Alison A., Dennis Ross-Degnan, Fang Zhang, Ann Chen Wu, Anna Sinaiko, Robert F. LeCates, Jamie Wallace, Alon Peltz, and J Frank Wharam. “Association of Controller Use and Exacerbations for High-Deductible Plan Enrollees with and without Family Members with Asthma.” Ann Am Thorac Soc 18, no. 7 (July 2021): 1255–60. https://doi.org/10.1513/AnnalsATS.202008-1084RL.Full Text Link to Item
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Lewis, Kristina H., David E. Arterburn, Fang Zhang, Katherine Callaway, Jamie Wallace, Adolfo Fernandez, Dennis Ross-Degnan, and James F. Wharam. “Comparative Effectiveness of Vertical Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass for Diabetes Treatment: A Claims-based Cohort Study.” Ann Surg 273, no. 5 (May 1, 2021): 940–48. https://doi.org/10.1097/SLA.0000000000003391.Full Text Link to Item
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Wharam, J Frank, Jamie Wallace, Robert F. LeCates, Jeanne M. Madden, Fang Zhang, Dennis Ross-Degnan, and Christine Y. Lu. “Out-of-Pocket Spending Inequity Among High-Deductible Health Plan Members with Bipolar Disorder.” J Gen Intern Med, April 12, 2021. https://doi.org/10.1007/s11606-021-06773-x.Full Text Link to Item
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Wagner, Anita Katharina, Peter A. Ubel, and J Frank Wharam. “Financial Pollution in the US Health Care System.” Jama Health Forum 2, no. 3 (March 1, 2021): e210195. https://doi.org/10.1001/jamahealthforum.2021.0195.Full Text Link to Item
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Madden, Jeanne M., Carina Araujo-Lane, Phyllis Foxworth, Christine Y. Lu, J Frank Wharam, Alisa B. Busch, Stephen B. Soumerai, and Dennis Ross-Degnan. “Experiences of health care costs among people with employer-sponsored insurance and bipolar disorder.” J Affect Disord 281 (February 15, 2021): 41–50. https://doi.org/10.1016/j.jad.2020.10.033.Full Text Link to Item
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Ferrario, Alessandra, Xin Xu, Fang Zhang, Dennis Ross-Degnan, J Frank Wharam, and Anita K. Wagner. “Intensity of End-of-Life Care in a Cohort of Commercially Insured Women With Metastatic Breast Cancer in the United States.” Jco Oncol Pract 17, no. 2 (February 2021): e194–203. https://doi.org/10.1200/OP.20.00089.Full Text Link to Item
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Madden, Jeanne M., Phyllis M. Foxworth, Dennis Ross-Degnan, Kimberly G. Allen, Alisa B. Busch, Matthew X. Callahan, Christine Y. Lu, and James F. Wharam. “Integrating Stakeholder Engagement With Claims-Based Research on Health Insurance Design and Bipolar Disorder.” Psychiatr Serv 72, no. 2 (February 1, 2021): 186–94. https://doi.org/10.1176/appi.ps.202000177.Full Text Link to Item
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Lewis, Kristina H., Katherine Callaway, Stephanie Argetsinger, Jamie Wallace, David E. Arterburn, Fang Zhang, Adolfo Fernandez, Dennis Ross-Degnan, Justin B. Dimick, and J Frank Wharam. “Concurrent hiatal hernia repair and bariatric surgery: outcomes after sleeve gastrectomy and Roux-en-Y gastric bypass.” Surg Obes Relat Dis 17, no. 1 (January 2021): 72–80. https://doi.org/10.1016/j.soard.2020.08.035.Full Text Link to Item
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Meiri, Amir, Dennis Ross-Degnan, and J Frank Wharam. “Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin-Reply.” Jama Intern Med 181, no. 1 (January 1, 2021): 141–42. https://doi.org/10.1001/jamainternmed.2020.5047.Full Text Link to Item
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Ramachandran, Bharathi, Connie M. Trinacty, J Frank Wharam, O Kenrik Duru, Wendy T. Dyer, Romain S. Neugebauer, Andrew J. Karter, et al. “A Randomized Encouragement Trial to Increase Mail Order Pharmacy Use and Medication Adherence in Patients with Diabetes.” J Gen Intern Med 36, no. 1 (January 2021): 154–61. https://doi.org/10.1007/s11606-020-06237-8.Full Text Link to Item
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Wernli, Karen J., Katherine A. Callaway, Louise M. Henderson, Karla Kerlikowske, Janie M. Lee, Dennis Ross-Degnan, Jamie K. Wallace, J Frank Wharam, Fang Zhang, and Natasha K. Stout. “Trends in screening breast magnetic resonance imaging use among US women, 2006 to 2016.” Cancer 126, no. 24 (December 15, 2020): 5293–5302. https://doi.org/10.1002/cncr.33140.Full Text Link to Item
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Li, Xiaojuan, Kristina H. Lewis, Katherine Callaway, J Frank Wharam, and Sengwee Toh. “Suitability of administrative claims databases for bariatric surgery research - is the glass half-full or half-empty?” Bmc Med Res Methodol 20, no. 1 (September 7, 2020): 225. https://doi.org/10.1186/s12874-020-01106-8.Full Text Link to Item
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Kim, Yuhree, Fang Zhang, Katherine Su, Marc LaRochelle, Matthew Callahan, David Fisher, J Frank Wharam, and Maryam M. Asgari. “Perioperative Serum 25-Hydroxyvitamin D Levels as a Predictor of Postoperative Opioid Use and Opioid Use Disorder: a Cohort Study.” J Gen Intern Med 35, no. 9 (September 2020): 2545–52. https://doi.org/10.1007/s11606-020-06001-y.Full Text Link to Item
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Macías, C Gabriela, James F. Wharam, Bradley A. Maron, and Mei-Sing Ong. “Urban-Rural Disparities in Pulmonary Hypertension Mortality.” Ann Am Thorac Soc 17, no. 9 (September 2020): 1168–71. https://doi.org/10.1513/AnnalsATS.202003-234RL.Full Text Link to Item
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Garabedian, Laura F., Robert LeCates, Alison Galbraith, Dennis Ross-Degnan, and J Frank Wharam. “Costs Are Higher For Marketplace Members Who Enroll During Special Enrollment Periods Compared With Open Enrollment.” Health Aff (Millwood) 39, no. 8 (August 2020): 1354–61. https://doi.org/10.1377/hlthaff.2019.01155.Full Text Link to Item
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Meiri, Amir, Fang Zhang, Dennis Ross-Degnan, and J Frank Wharam. “Trends in Insulin Out-of-Pocket Costs and Reimbursement Price Among US Patients With Private Health Insurance, 2006-2017.” Jama Intern Med 180, no. 7 (July 1, 2020): 1010–12. https://doi.org/10.1001/jamainternmed.2020.1302.Full Text Link to Item
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Wharam, J Frank, Jamie Wallace, Fang Zhang, Xin Xu, Christine Y. Lu, Adrian Hernandez, Dennis Ross-Degnan, and Joseph P. Newhouse. “Association Between Switching to a High-Deductible Health Plan and Major Cardiovascular Outcomes.” Jama Netw Open 3, no. 7 (July 1, 2020): e208939. https://doi.org/10.1001/jamanetworkopen.2020.8939.Full Text Link to Item
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Ross-Degnan, Dennis, Jamie Wallace, Fang Zhang, Stephen B. Soumerai, Laura Garabedian, and J Frank Wharam. “Reduced Cost-sharing for Preventive Drugs Preferentially Benefits Low-income Patients With Diabetes in High Deductible Health Plans With Health Savings Accounts.” Med Care 58 Suppl 6 Suppl 1, no. Suppl 6 1 (June 2020): S4–13. https://doi.org/10.1097/MLR.0000000000001295.Full Text Link to Item
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Trad, Nicolas K., J Frank Wharam, and Benjamin Druss. “Addressing Loneliness in the Era of COVID-19.” Jama Health Forum 1, no. 6 (June 1, 2020): e200631. https://doi.org/10.1001/jamahealthforum.2020.0631.Full Text Link to Item
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Wharam, J Frank, Alisa B. Busch, Jeanne Madden, Fang Zhang, Matthew Callahan, Robert F. LeCates, Phyllis Foxworth, Stephen Soumerai, Dennis Ross-Degnan, and Christine Y. Lu. “Effect of high-deductible insurance on health care use in bipolar disorder.” Am J Manag Care 26, no. 6 (June 2020): 248–55. https://doi.org/10.37765/ajmc.2020.43487.Full Text Link to Item
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Hong, Arthur S., David Levin, Laurence Parker, Vijay M. Rao, Dennis Ross-Degnan, and J Frank Wharam. “Trends in Diagnostic Imaging Utilization among Medicare and Commercially Insured Adults from 2003 through 2016.” Radiology 294, no. 2 (February 2020): 342–50. https://doi.org/10.1148/radiol.2019191116.Full Text Link to Item
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Lewis, Kristina H., David E. Arterburn, Katherine Callaway, Fang Zhang, Stephanie Argetsinger, Jamie Wallace, Adolfo Fernandez, Dennis Ross-Degnan, and James F. Wharam. “Risk of Operative and Nonoperative Interventions Up to 4 Years After Roux-en-Y Gastric Bypass vs Vertical Sleeve Gastrectomy in a Nationwide US Commercial Insurance Claims Database.” Jama Netw Open 2, no. 12 (December 2, 2019): e1917603. https://doi.org/10.1001/jamanetworkopen.2019.17603.Full Text Link to Item
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Garabedian, Laura F., Dennis Ross-Degnan, Robert F. LeCates, and James F. Wharam. “Uptake and use of a diabetes management program with a mobile glucometer.” Prim Care Diabetes 13, no. 6 (December 2019): 549–55. https://doi.org/10.1016/j.pcd.2019.03.010.Full Text Link to Item
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Wharam, J Frank, and Joseph P. Newhouse. “High-Deductible Insurance and Delay in Care.” Ann Intern Med 171, no. 3 (August 6, 2019): 226. https://doi.org/10.7326/L19-0205.Full Text Link to Item
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Schmittdiel, Julie A., Cassondra J. Marshall, Deanne Wiley, Christopher V. Chau, Connie M. Trinacty, J Frank Wharam, O Kenrik Duru, Andrew J. Karter, and Susan D. Brown. “Opportunities to encourage mail order pharmacy delivery service use for diabetes prescriptions: a qualitative study.” Bmc Health Serv Res 19, no. 1 (June 25, 2019): 422. https://doi.org/10.1186/s12913-019-4250-7.Full Text Link to Item
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Chou, Shih-Chuan, Justine M. Nagurney, Scott G. Weiner, Arthur S. Hong, and J Frank Wharam. “Trends in advanced imaging and hospitalization for emergency department syncope care before and after ACEP clinical policy.” Am J Emerg Med 37, no. 6 (June 2019): 1037–43. https://doi.org/10.1016/j.ajem.2018.08.043.Full Text Link to Item
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Garabedian, Laura F., Dennis Ross-Degnan, and James F. Wharam. “Provider Perspectives on Quality Payment Programs Targeting Diabetes in Primary Care Settings.” Popul Health Manag 22, no. 3 (June 2019): 248–54. https://doi.org/10.1089/pop.2018.0093.Full Text Link to Item
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Haffajee, Rebecca L., Michelle M. Mello, Fang Zhang, Alisa B. Busch, Alan M. Zaslavsky, and J Frank Wharam. “Association of Federal Mental Health Parity Legislation With Health Care Use and Spending Among High Utilizers of Services.” Med Care 57, no. 4 (April 2019): 245–55. https://doi.org/10.1097/MLR.0000000000001076.Full Text Link to Item
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Wharam, J Frank, Fang Zhang, Jamie Wallace, Christine Lu, Craig Earle, Stephen B. Soumerai, Larissa Nekhlyudov, and Dennis Ross-Degnan. “Vulnerable And Less Vulnerable Women In High-Deductible Health Plans Experienced Delayed Breast Cancer Care.” Health Aff (Millwood) 38, no. 3 (March 2019): 408–15. https://doi.org/10.1377/hlthaff.2018.05026.Full Text Link to Item
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Chang, Matthew S., J Frank Wharam, Fang Zhang, Robert F. LeCates, Emma Morton-Eggleston, Ruth E. Tuomala, Anna E. Rutherford, et al. “Peripartum Maternal Hepatitis B Care in a US Nationwide Data Set.” J Clin Gastroenterol 53, no. 10 (2019): e424–30. https://doi.org/10.1097/MCG.0000000000001122.Full Text Link to Item
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Panozzo, Catherine A., Melissa B. Gilkey, Melanie L. Kornides, and J Frank Wharam. “Provider-level rates of HEDIS-consistent HPV vaccination in a regional health plan.” Hum Vaccin Immunother 15, no. 7–8 (2019): 1708–14. https://doi.org/10.1080/21645515.2019.1574150.Full Text Link to Item
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Wharam, J Frank, Christine Y. Lu, Fang Zhang, Matthew Callahan, Xin Xu, Jamie Wallace, Stephen Soumerai, Dennis Ross-Degnan, and Joseph P. Newhouse. “High-Deductible Insurance and Delay in Care for the Macrovascular Complications of Diabetes.” Ann Intern Med 169, no. 12 (December 18, 2018): 845–54. https://doi.org/10.7326/M17-3365.Full Text Link to Item
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Ali, Mohammed K., Frank Wharam, O. Kenrik Duru, Julie Schmittdiel, Ronald T. Ackermann, Jeanine Albu, Dennis Ross-Degnan, et al. “Advancing Health Policy and Program Research in Diabetes: Findings from the Natural Experiments for Translation in Diabetes (NEXT-D) Network.” Curr Diab Rep 18, no. 12 (November 20, 2018): 146. https://doi.org/10.1007/s11892-018-1112-3.Full Text Link to Item
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Leopold, Christine, Anita K. Wagner, Fang Zhang, Christine Y. Lu, Craig C. Earle, Larissa Nekhlyudov, Dennis Ross-Degnan, and J Frank Wharam. “Total and out-of-pocket expenditures among women with metastatic breast cancer in low-deductible versus high-deductible health plans.” Breast Cancer Res Treat 171, no. 2 (September 2018): 449–59. https://doi.org/10.1007/s10549-018-4819-6.Full Text Link to Item
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Lu, Christine Y., Fang Zhang, Anita K. Wagner, Larissa Nekhlyudov, Craig C. Earle, Matthew Callahan, Robert LeCates, Xin Xu, Dennis Ross-Degnan, and J Frank Wharam. “Impact of high-deductible insurance on adjuvant hormonal therapy use in breast cancer.” Breast Cancer Res Treat 171, no. 1 (August 2018): 235–42. https://doi.org/10.1007/s10549-018-4821-z.Full Text Link to Item
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Haffajee, Rebecca L., Michelle M. Mello, Fang Zhang, Alan M. Zaslavsky, Marc R. Larochelle, and J Frank Wharam. “Four States With Robust Prescription Drug Monitoring Programs Reduced Opioid Dosages.” Health Aff (Millwood) 37, no. 6 (June 2018): 964–74. https://doi.org/10.1377/hlthaff.2017.1321.Full Text Link to Item
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Wharam, J Frank, Fang Zhang, Emma M. Eggleston, Christine Y. Lu, Stephen B. Soumerai, and Dennis Ross-Degnan. “Effect of High-Deductible Insurance on High-Acuity Outcomes in Diabetes: A Natural Experiment for Translation in Diabetes (NEXT-D) Study.” Diabetes Care 41, no. 5 (May 2018): 940–48. https://doi.org/10.2337/dc17-1183.Full Text Link to Item
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Wharam, J Frank, Fang Zhang, Christine Y. Lu, Anita K. Wagner, Larissa Nekhlyudov, Craig C. Earle, Stephen B. Soumerai, and Dennis Ross-Degnan. “Breast Cancer Diagnosis and Treatment After High-Deductible Insurance Enrollment.” J Clin Oncol 36, no. 11 (April 10, 2018): 1121–27. https://doi.org/10.1200/JCO.2017.75.2501.Full Text Link to Item
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Hong, Arthur S., Dennis Ross-Degnan, and J Frank Wharam. “Drivers of Low-Value Care-Reply.” Jama Intern Med 178, no. 3 (March 1, 2018): 433–34. https://doi.org/10.1001/jamainternmed.2017.8537.Full Text Link to Item
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Duru, O Kenrik, Carol M. Mangione, Hector P. Rodriguez, Dennis Ross-Degnan, J Frank Wharam, Bernard Black, Abel Kho, et al. “Introductory Overview of the Natural Experiments for Translation in Diabetes 2.0 (NEXT-D2) Network: Examining the Impact of US Health Policies and Practices to Prevent Diabetes and Its Complications.” Curr Diab Rep 18, no. 2 (February 5, 2018): 8. https://doi.org/10.1007/s11892-018-0977-5.Full Text Link to Item
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Hong, Arthur S., Dennis Ross-Degnan, Fang Zhang, and J Frank Wharam. “Clinician-Level Predictors for Ordering Low-Value Imaging.” Jama Intern Med 177, no. 11 (November 1, 2017): 1577–85. https://doi.org/10.1001/jamainternmed.2017.4888.Full Text Link to Item
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Lopez Bernal, James A., Christine Y. Lu, Antonio Gasparrini, Steven Cummins, J Frank Wharam, and Steven B. Soumerai. “Association between the 2012 Health and Social Care Act and specialist visits and hospitalisations in England: A controlled interrupted time series analysis.” Plos Med 14, no. 11 (November 2017): e1002427. https://doi.org/10.1371/journal.pmed.1002427.Full Text Link to Item
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Hadland, Scott E., J Frank Wharam, Mark A. Schuster, Fang Zhang, Jeffrey H. Samet, and Marc R. Larochelle. “Trends in Receipt of Buprenorphine and Naltrexone for Opioid Use Disorder Among Adolescents and Young Adults, 2001-2014.” Jama Pediatr 171, no. 8 (August 1, 2017): 747–55. https://doi.org/10.1001/jamapediatrics.2017.0745.Full Text Link to Item
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Hong, Arthur S., Dennis Ross-Degnan, Fang Zhang, and J Frank Wharam. “Small Decline In Low-Value Back Imaging Associated With The 'Choosing Wisely' Campaign, 2012-14.” Health Aff (Millwood) 36, no. 4 (April 1, 2017): 671–79. https://doi.org/10.1377/hlthaff.2016.1263.Full Text Link to Item
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Wharam, J Frank, Fang Zhang, Emma M. Eggleston, Christine Y. Lu, Stephen Soumerai, and Dennis Ross-Degnan. “Diabetes Outpatient Care and Acute Complications Before and After High-Deductible Insurance Enrollment: A Natural Experiment for Translation in Diabetes (NEXT-D) Study.” Jama Intern Med 177, no. 3 (March 1, 2017): 358–68. https://doi.org/10.1001/jamainternmed.2016.8411.Full Text Link to Item
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Leopold, Christine, Anita K. Wagner, Fang Zhang, Christine Y. Lu, Craig Earle, Larissa Nekhlyudov, Dennis Ross-Degnan, and J Frank Wharam. “Erratum to: Racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer.” Breast Cancer Res Treat 160, no. 2 (November 2016): 385. https://doi.org/10.1007/s10549-016-3988-4.Full Text Link to Item
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Larochelle, Marc R., Jane M. Liebschutz, Fang Zhang, Dennis Ross-Degnan, and J Frank Wharam. “Opioid Prescribing After Nonfatal Overdose and Association With Repeated Overdose.” Ann Intern Med 165, no. 5 (September 6, 2016): 376–77. https://doi.org/10.7326/L16-0168.Full Text Link to Item
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Eggleston, Emma Morton, Robert Franklin LeCates, Fang Zhang, James Franklin Wharam, Dennis Ross-Degnan, and Emily Oken. “Variation in Postpartum Glycemic Screening in Women With a History of Gestational Diabetes Mellitus.” Obstet Gynecol 128, no. 1 (July 2016): 159–67. https://doi.org/10.1097/AOG.0000000000001467.Full Text Link to Item
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Leopold, Christine, Anita K. Wagner, Fang Zhang, Christine Y. Lu, Craig Earle, Larissa Nekhlyudov, Dennis Ross-Degnan, and J Frank Wharam. “Racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer.” Breast Cancer Res Treat 158, no. 2 (July 2016): 333–40. https://doi.org/10.1007/s10549-016-3875-z.Full Text Link to Item
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Wharam, J Frank, Fang Zhang, Bruce E. Landon, Robert LeCates, Stephen Soumerai, and Dennis Ross-Degnan. “Colorectal Cancer Screening in a Nationwide High-deductible Health Plan Before and After the Affordable Care Act.” Med Care 54, no. 5 (May 2016): 466–73. https://doi.org/10.1097/MLR.0000000000000521.Full Text Link to Item
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Graves, Amy J., Katy B. Kozhimannil, Ken P. Kleinman, and J Frank Wharam. “The Association between High-Deductible Health Plan Transition and Contraception and Birth Rates.” Health Serv Res 51, no. 1 (February 2016): 187–204. https://doi.org/10.1111/1475-6773.12326.Full Text Link to Item
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Larochelle, Marc R., Jane M. Liebschutz, Fang Zhang, Dennis Ross-Degnan, and J Frank Wharam. “Opioid Prescribing After Nonfatal Overdose and Association With Repeated Overdose: A Cohort Study.” Ann Intern Med 164, no. 1 (January 5, 2016): 1–9. https://doi.org/10.7326/M15-0038.Full Text Link to Item
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Garabedian, Laura F., Dennis Ross-Degnan, and J Frank Wharam. “Mobile Phone and Smartphone Technologies for Diabetes Care and Self-Management.” Curr Diab Rep 15, no. 12 (December 2015): 109. https://doi.org/10.1007/s11892-015-0680-8.Full Text Link to Item
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Larochelle, Marc R., Fang Zhang, Dennis Ross-Degnan, and J Frank Wharam. “Trends in opioid prescribing and co-prescribing of sedative hypnotics for acute and chronic musculoskeletal pain: 2001-2010.” Pharmacoepidemiol Drug Saf 24, no. 8 (August 2015): 885–92. https://doi.org/10.1002/pds.3776.Full Text Link to Item
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Lewis, Kristina H., Fang Zhang, David E. Arterburn, Dennis Ross-Degnan, Matthew W. Gillman, and J Frank Wharam. “Comparing Medical Costs and Use After Laparoscopic Adjustable Gastric Banding and Roux-en-Y Gastric Bypass.” Jama Surg 150, no. 8 (August 2015): 787–94. https://doi.org/10.1001/jamasurg.2015.1081.Full Text Link to Item
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Ackermann, Ronald T., O. Kenrik Duru, Jeanine B. Albu, Julie A. Schmittdiel, Stephen B. Soumerai, James F. Wharam, Mohammed K. Ali, Carol M. Mangione, Edward W. Gregg, and Edward W. NEXT-D Study Group. “Evaluating diabetes health policies using natural experiments: the natural experiments for translation in diabetes study.” Am J Prev Med 48, no. 6 (June 2015): 747–54. https://doi.org/10.1016/j.amepre.2014.12.010.Full Text Link to Item
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Larochelle, Marc R., Fang Zhang, Dennis Ross-Degnan, and J Frank Wharam. “Rates of opioid dispensing and overdose after introduction of abuse-deterrent extended-release oxycodone and withdrawal of propoxyphene.” Jama Intern Med 175, no. 6 (June 2015): 978–87. https://doi.org/10.1001/jamainternmed.2015.0914.Full Text Link to Item
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Wharam, J Frank, Bruce Landon, Fang Zhang, Xin Xu, Stephen Soumerai, and Dennis Ross-Degnan. “Mammography rates 3 years after the 2009 US Preventive Services Task Force Guidelines changes.” J Clin Oncol 33, no. 9 (March 20, 2015): 1067–74. https://doi.org/10.1200/JCO.2014.56.9848.Full Text Link to Item
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Wharam, J Frank, Amy J. Graves, and Katy B. Kozhimannil. “Navigating the rise of high-deductible health insurance: childbirth in the bronze age.” Jama 313, no. 3 (January 20, 2015): 245–46. https://doi.org/10.1001/jama.2014.16085.Full Text Link to Item
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Wharam, J Frank, Bruce E. Landon, Xin Xu, Fang Zhang, and Dennis Ross-Degnan. “National Trends and Disparities in Mammography Among Commercially Insured Women, 2001-2010.” J Public Health Manag Pract 21, no. 5 (2015): 426–32. https://doi.org/10.1097/PHH.0000000000000101.Full Text Link to Item
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Stryjewski, Tomasz P., Fang Zhang, Dean Eliott, and J Frank Wharam. “Effect of Massachusetts health reform on chronic disease outcomes.” Health Serv Res 49 Suppl 2, no. Suppl 2 (December 2014): 2086–2103. https://doi.org/10.1111/1475-6773.12196.Full Text Link to Item
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Wharam, J Frank, Fang Zhang, Xin Xu, Bruce E. Landon, and Dennis Ross-Degnan. “National trends and disparities in cervical cancer screening among commercially insured Women, 2001-2010.” Cancer Epidemiol Biomarkers Prev 23, no. 11 (November 2014): 2366–73. https://doi.org/10.1158/1055-9965.EPI-13-1202.Full Text Link to Item
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Reddy, Sheila R., Dennis Ross-Degnan, Alan M. Zaslavsky, Stephen B. Soumerai, and James F. Wharam. “Impact of a high-deductible health plan on outpatient visits and associated diagnostic tests.” Med Care 52, no. 1 (January 2014): 86–92. https://doi.org/10.1097/MLR.0000000000000008.Full Text Link to Item
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Wharam, J Frank, Dennis Ross-Degnan, and Meredith B. Rosenthal. “The ACA and high-deductible insurance--strategies for sharpening a blunt instrument.” N Engl J Med 369, no. 16 (October 17, 2013): 1481–84. https://doi.org/10.1056/NEJMp1309490.Full Text Link to Item
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Kozhimannil, Katy B., Michael R. Law, Cori Blauer-Peterson, Fang Zhang, and James Frank Wharam. “The impact of high-deductible health plans on men and women: an analysis of emergency department care.” Med Care 51, no. 8 (August 2013): 639–45. https://doi.org/10.1097/MLR.0b013e31829742d0.Full Text Link to Item
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Wharam, J Frank, Fang Zhang, Bruce E. Landon, Stephen B. Soumerai, and Dennis Ross-Degnan. “Low-socioeconomic-status enrollees in high-deductible plans reduced high-severity emergency care.” Health Aff (Millwood) 32, no. 8 (August 2013): 1398–1406. https://doi.org/10.1377/hlthaff.2012.1426.Full Text Link to Item
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Wharam, J Frank, Steve Soumerai, Connie Trinacty, Emma Eggleston, Fang Zhang, Robert LeCates, Claire Canning, and Dennis Ross-Degnan. “Impact of emerging health insurance arrangements on diabetes outcomes and disparities: rationale and study design.” Prev Chronic Dis 10 (2013): E11. https://doi.org/10.5888/pcd10.120147.Full Text Link to Item
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Wharam, J Frank, Amy Johnson Graves, Fang Zhang, Stephen B. Soumerai, Dennis Ross-Degnan, and Bruce E. Landon. “Two-year trends in cancer screening among low socioeconomic status women in an HMO-based high-deductible health plan.” J Gen Intern Med 27, no. 9 (September 2012): 1112–19. https://doi.org/10.1007/s11606-012-2057-x.Full Text Link to Item
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Wharam, J Frank, and Jonathan P. Weiner. “The promise and peril of healthcare forecasting.” Am J Manag Care 18, no. 3 (March 1, 2012): e82–85.Link to Item
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Reiss, Sheila K., Dennis Ross-Degnan, Fang Zhang, Stephen B. Soumerai, Alan M. Zaslavsky, and J Frank Wharam. “Effect of switching to a high-deductible health plan on use of chronic medications.” Health Serv Res 46, no. 5 (October 2011): 1382–1401. https://doi.org/10.1111/j.1475-6773.2011.01252.x.Full Text Link to Item
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Wharam, J Frank, Bruce E. Landon, Fang Zhang, Stephen B. Soumerai, and Dennis Ross-Degnan. “High-deductible insurance: two-year emergency department and hospital use.” Am J Manag Care 17, no. 10 (October 1, 2011): e410–18.Link to Item
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Smulowitz, Peter B., Robert Lipton, J Frank Wharam, Leon Adelman, Scott G. Weiner, Laura Burke, Christopher W. Baugh, et al. “Emergency department utilization after the implementation of Massachusetts health reform.” Ann Emerg Med 58, no. 3 (September 2011): 225-234.e1. https://doi.org/10.1016/j.annemergmed.2011.02.020.Full Text Link to Item
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Wharam, James Frank, Amy Johnson Graves, Bruce E. Landon, Fang Zhang, Stephen B. Soumerai, and Dennis Ross-Degnan. “Two-year trends in colorectal cancer screening after switch to a high-deductible health plan.” Med Care 49, no. 9 (September 2011): 865–71. https://doi.org/10.1097/MLR.0b013e31821b35d8.Full Text Link to Item
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Kozhimannil, Katy Backes, Haiden A. Huskamp, Amy Johnson Graves, Stephen B. Soumerai, Dennis Ross-Degnan, and J Frank Wharam. “High-deductible health plans and costs and utilization of maternity care.” Am J Manag Care 17, no. 1 (January 2011): e17–25.Link to Item
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Wharam, J Frank, Matthew B. Frank, Ann-Marie Rosland, Michael K. Paasche-Orlow, Neil J. Farber, Christine Sinsky, Lisa Rucker, Kimberly J. Rask, Michael J. Barry, and M Kathleen Figaro. “"Pay-for-performance" as a quality improvement tool: perceptions and policy recommendations of physicians and program leaders.” Qual Manag Health Care 20, no. 3 (2011): 234–45. https://doi.org/10.1097/QMH.0b013e318222c398.Full Text Link to Item
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Galbraith, Alison A., Dennis Ross-Degnan, Stephen B. Soumerai, Allyson M. Abrams, Kenneth Kleinman, Meredith B. Rosenthal, J Frank Wharam, Alyce S. Adams, Irina Miroshnik, and Tracy A. Lieu. “Use of well-child visits in high-deductible health plans.” Am J Manag Care 16, no. 11 (November 2010): 833–40.Link to Item
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Zhang, Fang, J Frank Wharam, and Dennis Ross-Degnan. “Comparing simulation and threshold approaches when analysing data with probabilities of categories.” J Eval Clin Pract 16, no. 5 (October 2010): 964–67. https://doi.org/10.1111/j.1365-2753.2009.01239.x.Full Text Link to Item
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Wharam, J Frank, Michael K. Paasche-Orlow, Neil J. Farber, Christine Sinsky, Lisa Rucker, Kimberly J. Rask, M Kathleen Figaro, Clarence Braddock, Michael J. Barry, and Daniel P. Sulmasy. “High quality care and ethical pay-for-performance: a Society of General Internal Medicine policy analysis.” J Gen Intern Med 24, no. 7 (July 2009): 854–59. https://doi.org/10.1007/s11606-009-0947-3.Full Text Link to Item
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Wharam, J. F., and D. Sulmasy. “Resource use, patient education, and improving the quality of health care reply.” Jama 301, no. 19 (May 20, 2009): 1990. https://doi.org/10.1001/jama.2009.656.Full Text
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Galbraith, Alison A., Dennis Ross-Degnan, Stephen B. Soumerai, Irina Miroshnik, J Frank Wharam, Kenneth Kleinman, and Tracy A. Lieu. “High-deductible health plans: are vulnerable families enrolled?” Pediatrics 123, no. 4 (April 2009): e589–94. https://doi.org/10.1542/peds.2008-1738.Full Text Link to Item
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Wharam, J Frank, and Daniel Sulmasy. “Improving the quality of health care: who is responsible for what?” Jama 301, no. 2 (January 14, 2009): 215–17. https://doi.org/10.1001/jama.2008.964.Full Text Link to Item
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Wharam, J Frank, Alison A. Galbraith, Ken P. Kleinman, Stephen B. Soumerai, Dennis Ross-Degnan, and Bruce E. Landon. “Cancer screening before and after switching to a high-deductible health plan.” Ann Intern Med 148, no. 9 (May 6, 2008): 647–55. https://doi.org/10.7326/0003-4819-148-9-200805060-00004.Full Text Link to Item
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Wharam, J Frank, and Norman Daniels. “Toward evidence-based policy making and standardized assessment of health policy reform.” Jama 298, no. 6 (August 8, 2007): 676–79. https://doi.org/10.1001/jama.298.6.676.Full Text Link to Item
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Wharam, J Frank, Bruce E. Landon, Alison A. Galbraith, Ken P. Kleinman, Stephen B. Soumerai, and Dennis Ross-Degnan. “Emergency department use and subsequent hospitalizations among members of a high-deductible health plan.” Jama 297, no. 10 (March 14, 2007): 1093–1102. https://doi.org/10.1001/jama.297.10.1093.Full Text Link to Item
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Farrell, R. A., J. F. Wharam, D. Kim, and R. L. McCally. “Polarized light propagation in corneal lamellae.” J Refract Surg 15, no. 6 (1999): 700–705. https://doi.org/10.3928/1081-597X-19991101-19.Full Text Link to Item
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Yoshida, B. A., M. A. Chekmareva, J. F. Wharam, M. Kadkhodaian, W. M. Stadler, A. Boyer, K. Watabe, J. B. Nelson, and C. W. Rinker-Schaeffer. “Prostate cancer metastasis-suppressor genes: a current perspective.” In Vivo 12, no. 1 (1998): 49–58.Link to Item
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Rinker-Schaeffer, C. W., J. F. Wharam, J. Simons, and J. T. Isaacs. “Development of a high-efficiency method for gene marking of Dunning prostate cancer cell lines with the enzyme beta-galactosidase.” Prostate 29, no. 1 (July 1996): 60–64. https://doi.org/10.1002/(SICI)1097-0045(199607)29:1<60::AID-PROS9>3.0.CO;2-M.Full Text Link to Item
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Conference Papers
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Trad, Nicolas Karim, Michael J. Hassett, Fang Zhang, and J Frank Wharam. “Impact of high-deductible health plans on delays in metastatic cancer diagnosis.” In Journal of Clinical Oncology, Vol. 40, 2022.Link to Item
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Kan, Kristin, and Ruchi S. Gupta. “Controller Medication Use and Exacerbations for Children and Adults With Asthma in High-Deductible Health Plans.” In Pediatrics, 148:S54–S54. American Academy of Pediatrics (AAP), 2021. https://doi.org/10.1542/peds.2021-053843aaaa.Full Text
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Wharam, James F., Fang Zhang, Christine Lu, Adrian F. Hernandez, Matthew X. Callahan, Xin Xu, Jamie Wallace, Stephen B. Soumerai, Dennis Ross-Degnan, and Joseph P. Newhouse. “EFFECT OF HIGH-DEDUCTIBLE INSURANCE ON MYOCARDIAL INFARCTION, STROKE, AND AMPUTATION.” In Journal of General Internal Medicine, 33:S176–S176. SPRINGER, 2018.Link to Item
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