Stephanie Freel
Adjunct Assistant Professor in the Department of Pediatrics
Current Appointments & Affiliations
- Adjunct Assistant Professor in the Department of Pediatrics, Pediatrics, Children's Health Discovery Institute, Pediatrics 2019
Contact Information
- 2200 West Main Street, Box21, Durham, NC 27710
- DUMC 104028, 2200 West Main Street, Durham, NC 27710
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freels@duke.edu
(919) 660-9181
- Background
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Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2002
- Research
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Selected Grants
- Duke Physician Scientist Development program awarded by Burroughs Wellcome Fund 2018 - 2023
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- Optimizing Lupus Management in Pregnancy awarded by Agency for Healthcare Research and Quality 2015 - 2017
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.” Sci Rep 9, no. 1 (July 15, 2019): 10165. https://doi.org/10.1038/s41598-019-46462-8.Full Text Open Access Copy Link to Item
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Freel, Stephanie A., Paige C. Smith, Ebony N. Burns, Joanna B. Downer, Ann J. Brown, and Mark W. Dewhirst. “Multidisciplinary Mentoring Programs to Enhance Junior Faculty Research Grant Success.” Acad Med 92, no. 10 (October 2017): 1410–15. https://doi.org/10.1097/ACM.0000000000001620.Full Text Link to Item
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Payne, Tamika L., Jeff Blackinton, Alyse Frisbee, Joy Pickeral, Sheetal Sawant, Nathan A. Vandergrift, Stephanie A. Freel, Guido Ferrari, Jack D. Keene, and Georgia D. Tomaras. “Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition.” J Virol 88, no. 17 (September 1, 2014): 9514–28. https://doi.org/10.1128/JVI.00802-14.Full Text Link to Item
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Freel, Stephanie A., Ralph A. Picking, Guido Ferrari, Haitao Ding, Christina Ochsenbauer, John C. Kappes, Jennifer L. Kirchherr, et al. “Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication.” J Virol 86, no. 12 (June 2012): 6835–46. https://doi.org/10.1128/JVI.00437-12.Full Text Open Access Copy Link to Item
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Liu, Pinghuang, R Glenn Overman, Nicole L. Yates, S Munir Alam, Nathan Vandergrift, Yue Chen, Frederik Graw, et al. “Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection.” J Virol 85, no. 21 (November 2011): 11196–207. https://doi.org/10.1128/JVI.05601-11.Full Text Link to Item
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Jiang, Chunlai, Nicholas F. Parrish, Craig B. Wilen, Hui Li, Yue Chen, Jeffrey W. Pavlicek, Anna Berg, et al. “Primary infection by a human immunodeficiency virus with atypical coreceptor tropism.” J Virol 85, no. 20 (October 2011): 10669–81. https://doi.org/10.1128/JVI.05249-11.Full Text Link to Item
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Ferrari, Guido, Justin Pollara, Daniel Kozink, Tiara Harms, Mark Drinker, Stephanie Freel, M Anthony Moody, et al. “An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.” J Virol 85, no. 14 (July 2011): 7029–36. https://doi.org/10.1128/JVI.00171-11.Full Text Link to Item
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Freel, Stephanie A., Kevin O. Saunders, and Georgia D. Tomaras. “CD8(+)T-cell-mediated control of HIV-1 and SIV infection.” Immunol Res 49, no. 1–3 (April 2011): 135–46. https://doi.org/10.1007/s12026-010-8177-7.Full Text Link to Item
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Saunders, Kevin O., Cavin Ward-Caviness, Robert J. Schutte, Stephanie A. Freel, R Glenn Overman, Nathan M. Thielman, Coleen K. Cunningham, Thomas B. Kepler, and Georgia D. Tomaras. “Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage.” Cell Immunol 266, no. 2 (2011): 154–64. https://doi.org/10.1016/j.cellimm.2010.09.011.Full Text Link to Item
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Saunders, Kevin O., Stephanie A. Freel, R Glenn Overman, Coleen K. Cunningham, and Georgia D. Tomaras. “Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication.” Virology 405, no. 1 (September 15, 2010): 234–42. https://doi.org/10.1016/j.virol.2010.06.001.Full Text Link to Item
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Freel, Stephanie A., Laurie Lamoreaux, Pratip K. Chattopadhyay, Kevin Saunders, David Zarkowsky, R Glenn Overman, Christina Ochsenbauer, et al. “Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination.” J Virol 84, no. 10 (May 2010): 4998–5006. https://doi.org/10.1128/JVI.00138-10.Full Text Open Access Copy Link to Item
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Lu, Rong-Jian, John A. Tucker, Jason Pickens, You-An Ma, Tatiana Zinevitch, Olga Kirichenko, Vitalii Konoplev, et al. “Heterobiaryl human immunodeficiency virus entry inhibitors.” J Med Chem 52, no. 14 (July 23, 2009): 4481–87. https://doi.org/10.1021/jm900330x.Full Text Link to Item
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Lu, Rong-Jian, John A. Tucker, Tatiana Zinevitch, Olga Kirichenko, Vitalii Konoplev, Svetlana Kuznetsova, Sergey Sviridov, et al. “Design and synthesis of human immunodeficiency virus entry inhibitors: sulfonamide as an isostere for the alpha-ketoamide group.” J Med Chem 50, no. 26 (December 27, 2007): 6535–44. https://doi.org/10.1021/jm070650e.Full Text Link to Item
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Dwyer, John J., Karen L. Wilson, Donna K. Davison, Stephanie A. Freel, Jennifer E. Seedorff, Stephen A. Wring, Nicolai A. Tvermoes, Thomas J. Matthews, Michael L. Greenberg, and Mary K. Delmedico. “Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus.” Proceedings of the National Academy of Sciences of the United States of America 104, no. 31 (July 2007): 12772–77. https://doi.org/10.1073/pnas.0701478104.Full Text
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Freel, S. A., S. A. Fiscus, C. D. Pilcher, P. Menezes, J. Giner, E. Patrick, J. L. Lennox, C. B. Hicks, J. J. Eron, and D. C. Shugars. “Envelope diversity, coreceptor usage and syncytium-inducing phenotype of HIV-1 variants in saliva and blood during primary infection.” Aids (London, England) 17, no. 14 (September 2003): 2025–33.
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Shugars, D. C., S. A. Freel, S. A. Fiscus, C. D. Pilcher, J. L. Lennox, C. B. Hicks, and J. J. Eron. “Envelope diversity, Co-receptor usage, and syncytium-inducing phenotype of HIV-1 variants in oral fluids and blood during primary infection.” Journal of Dental Research 82 (June 1, 2003): B234–B234.Link to Item
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Freel, S. A., J. M. Williams, J. A. Nelson, L. L. Patton, S. A. Fiscus, R. Swanstrom, and D. C. Shugars. “Characterization of human immunodeficiency virus type 1 in saliva and blood plasma by V3-specific heteroduplex tracking assay and genotype analyses.” Journal of Virology 75, no. 10 (May 2001): 4936–40. https://doi.org/10.1128/jvi.75.10.4936-4940.2001.Full Text
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Shugars, D. C., L. L. Patton, S. A. Freel, L. R. Gray, R. T. Vollmer, J. J. Eron, and S. A. Fiscus. “Hyper-excretion of human immunodeficiency virus type 1 RNA in saliva.” Journal of Dental Research 80, no. 2 (February 2001): 414–20. https://doi.org/10.1177/00220345010800020301.Full Text
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Shugars, D. C., S. A. Freel, S. A. Fiscus, C. Pilcher, C. Giner, B. Dean, P. Menezes, J. J. Eron, J. L. Lennox, and C. B. Hicks. “Salivary, genital and plasma viral loads and responses to combination antiretrovir therapy in primary HIV infection.” Journal of Dental Research 79 (January 1, 2000): 238–238.Link to Item
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Shugars, D. C., A. L. Alexander, K. Fu, and S. A. Freel. “Endogenous salivary inhibitors of human immunodeficiency virus.” Archives of Oral Biology 44, no. 6 (June 1999): 445–53. https://doi.org/10.1016/s0003-9969(99)00003-5.Full Text
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Conference Papers
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Blackinton, J., M. Thompson, N. Mukherjee, S. Freel, G. Tomaras, and J. Keene. “Integration of global techniques to implicate post-transcriptional regulation in HIV infection.” In Journal of the International Aids Society, 15:23–23. JOHN WILEY & SONS LTD, 2012.Link to Item
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Ferrari, G., J. Pollara, D. Kozink, T. Harms, M. Drinker, S. Freel, M. A. Moody, et al. “Mapping of ADCC Activity: The A32 Conformational C1 Epitope is a Dominant Target for ADCC Antibodies in Chronically HIV-1 Infected Subjects.” In Aids Research and Human Retroviruses, 27:A66–A66. MARY ANN LIEBERT INC, 2011.Link to Item
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Freel, S. A., R. A. Picking, G. Ferrari, C. Ochsenbauer, J. C. Kappes, J. Kirchherr, K. J. Weinhold, et al. “Ontogeny of CD8+T Cells in Acute HIV-1 that Inhibit Autologous and Heterologous Transmitted/Founder (T/F) Viruses.” In Aids Research and Human Retroviruses, 27:A13–A13. MARY ANN LIEBERT INC, 2011.Link to Item
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Yang, H., H. Wu, S. A. Freel, H. Yan, X. Huang, X. Xu, J. Birks, G. D. Tomaras, A. McMichael, and L. Dorrell. “The CD8+T Cell Antiviral Inhibitory Activity Predicts the Rate of CD4+Cell Decline in Early HIV-1 Infection and Is Independent of Viral Subtype.” In Aids Research and Human Retroviruses, 27:A91–A91. MARY ANN LIEBERT INC, 2011.Link to Item
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“Abstracts of AIDS Vaccine 2009. Paris, France. October 19-22, 2009.” In Retrovirology, 6 Suppl 3:O1-425, 2009. https://doi.org/10.1186/1742-4690-6-s3-o1.Full Text
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Saunders, K. O., S. A. Freel, R. Overman, C. K. Cunningham, and G. D. Tomaras. “Inhibition of histone deacetylases modulates CD8+T-lymphocyte mediated virus suppression by HIV-1 viral controllers.” In Retrovirology, Vol. 6, 2009. https://doi.org/10.1186/1742-4690-6-S3-P269.Full Text Link to Item
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- Teaching & Mentoring
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Recent Courses
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