Herbert Edgar Fuchs | Scholars@Duke

Herbert Edgar Fuchs
Professor of Neurosurgery

Clinical neuro-oncology research including collaborations studying molecular genetics of childhood brain tumors.
Potential role of the free electron laser in surgery of pediatric brain tumors. Current work includes animal models with human brain tumor xenografts in preclinical studies.
Collaboration with the neurooncology laboratory of Dr. Darell Bigner in preclinical studies of new therapeutic agents.

Current Appointments & Affiliations

Professor of Neurosurgery, Neurosurgery, Neurosurgery 2017
Assistant Professor of Pathology, Pathology, Clinical Science Departments 1995
Professor of Pediatrics, Pediatrics, Clinical Science Departments 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1992

Contact Information

4544 Hospital South, Box 3807, Durham, NC 27710
Box 3807, Durham, NC 27710
fuchs001@mc.duke.edu (919) 681-0894

Background
Education, Training, & Certifications
- M.D., Duke University 1984
- Ph.D., Duke University 1984
Duke Appointment History
- Assistant Professor of Pediatrics, Pediatrics, Clinical Science Departments 1995 - 2018
- Associate Professor of Neurosurgery, Neurosurgery, Neurosurgery 2002 - 2017
- Associate Professor of Surgery, Neurosurgery, Neurosurgery 1996 - 2002
- Assistant Professor of Pediatric Neurosurgery in the Department of Surgery, Neurosurgery, Neurosurgery 1993 - 1996
Research
Selected Grants
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Linkage and candidate gene analysis in non-syndromic Chiari type I awarded by National Institutes of Health 2009 - 2015
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- Src On Primary And Matastatic Tumors Of The Cns awarded by National Institutes of Health 1994 - 1999
- Src On Primary And Metastatic Tumors Of The Cns awarded by National Institutes of Health 1997 - 1999
- Src On Malignant Human Gliomas And Medulloblastomas awarded by National Institutes of Health 1993 - 1994
Publications & Artistic Works
Selected Publications
- Book Sections
  - Fuchs, HE. "Congenital neurosurgical problems." In Emergency Approaches to Neurosurgical Conditions, 65-69. January 1, 2015. Full Text
- Conference Papers
  - He, Y, Lopez, G, Grant, G, Fuchs, H, Leithe, L, Gururangan, S, Bigner, D, Yan, H, and Mclendon, R. "CLINICAL PATHOLOGIC DESCRIPTION OF THREE PEDIATRIC MEDULLOBLASTOMA CASES WITH MLL2/3 GENE MUTATIONS." May 2011. Link to Item
  - Cummings, TJ, Bulsara, KR, McLendon, RE, Fuchs, HE, and George, TM. "Pathology of the normal versus the tethered filum terminale." May 2001. Link to Item
  - Cummings, TJ, Fuchs, HE, and George, TM. "Pathology of the filum terminale in the tethered spinal cord syndrome." January 2001. Link to Item
  - Cummings, TJ, Fuchs, HE, and George, TM. "Pathology of the filum terminale in the tethered spinal cord syndrome." January 2001. Link to Item
  - MCLENDON, RE, FRIEDMAN, HS, LONGEE, DC, FUCHS, HE, and HESSLER, RB. "SYNCHRONOUS EPENDYMO-GLIOMAS." May 1995. Full Text Link to Item
  - ARCHER, GE, SCHUSTER, JM, FUCHS, HE, GUASPARI, A, BIGNER, DD, FRIEDMAN, HS, and MCLENDON, RE. "NEUROPATHOLOGY OF MULTIPLE VERSUS SINGLE-DOSE INTRATHECAL MELPHALAN IN RATS." May 1993. Full Text Link to Item
  - FUCHS, HE, ARCHER, GE, SCHUSTER, JM, COLVIN, OM, BIGNER, SH, MUHLBAIER, LH, FRIEDMAN, HS, and BIGNER, DD. "A NUDE RAT MODEL OF LEPTOMENINGEAL TUMOR DISSEMINATION (LTD) OF HUMAN MEDULLOBLASTOMA." May 1989. Full Text Link to Item
  - HOFFMAN, MR, FUCHS, HE, and PIZZO, SV. "SYNTHESIS OF ANTITHROMBIN-III BY CULTURED RAT HEPATOCYTES." 1984. Link to Item
  - FUCHS, HE, and PIZZO, SV. "THE CATABOLISM OF HUMAN FACTOR-XA IN A MOUSE MODEL." 1983. Link to Item
- Journal Articles
  - Dai, R, Pien, IJ, Brown, DA, Marshall, A, Fuchs, HE, and Marcus, JR. "Multiple Recurrent Fibromatosis With Cranial Fasciitis Characteristics in a Pediatric Patient." The Journal of craniofacial surgery 28, no. 7 (October 2017): 1821-1823. Full Text
  - McKinnon, EL, Rand, AJ, Selim, MA, Fuchs, HE, Buckley, AF, and Cummings, TJ. "Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism." Journal of cutaneous pathology 42, no. 10 (October 2015): 774-778. Full Text
  - Nair, SK, Driscoll, T, Boczkowski, D, Schmittling, R, Reynolds, R, Johnson, LA, Grant, G, Fuchs, H, Bigner, DD, Sampson, JH, Gururangan, S, and Mitchell, DA. "Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma." Journal of neuro-oncology 125, no. 1 (October 2015): 65-74. Full Text
  - McLendon, RE, Lipp, E, Satterfield, D, Ehinger, M, Austin, A, Fleming, D, Perkinson, K, Lefaivre, M, Zagzag, D, Wiener, B, Gururangan, S, Fuchs, H, Friedman, HS, Herndon, JE, and Healy, P. "Prognostic marker analysis in pediatric intracranial ependymomas." Journal of neuro-oncology 122, no. 2 (April 2015): 255-261. Full Text
  - Lock, EF, Soldano, KL, Garrett, ME, Cope, H, Markunas, CA, Fuchs, H, Grant, G, Dunson, DB, Gregory, SG, and Ashley-Koch, AE. "Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation." BMC genomics 16 (January 22, 2015): 11-. Full Text Open Access Copy
  - Markunas, CA, Lock, E, Soldano, K, Cope, H, Ding, C-KC, Enterline, DS, Grant, G, Fuchs, H, Ashley-Koch, AE, and Gregory, SG. "Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics." BMC medical genomics 7 (June 25, 2014): 39-. Full Text
  - Lopez, GY, Grant, GA, Fuchs, HE, Leithe, LG, Gururangan, S, Bigner, DD, Yan, H, McLendon, RE, and He, Y. "Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations." NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 40, no. 2 (February 2014): 217-220. Full Text Link to Item
  - Markunas, CA, Enterline, DS, Dunlap, K, Soldano, K, Cope, H, Stajich, J, Grant, G, Fuchs, H, Gregory, SG, and Ashley-Koch, AE. "Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation." Ann Hum Genet 78, no. 1 (January 2014): 1-12. Full Text Link to Item
  - Markunas, CA, Soldano, K, Dunlap, K, Cope, H, Asiimwe, E, Stajich, J, Enterline, D, Grant, G, Fuchs, H, Gregory, SG, and Ashley-Koch, AE. "Stratified whole genome linkage analysis of Chiari type I malformation implicates known Klippel-Feil syndrome genes as putative disease candidates. (Published online)" PLoS One 8, no. 4 (2013): e61521-. Full Text Link to Item
  - Choi, BD, Hodges, TR, Grant, GA, Fuchs, HE, Cummings, TJ, and Muh, CR. "Inflammatory pseudotumor of the lateral ventricle in a pediatric patient." Pediatr Neurosurg 48, no. 6 (2012): 374-378. Full Text Link to Item
  - Parker, SR, Harris, P, Cummings, TJ, George, T, Fuchs, H, and Grant, G. "Complications following decompression of Chiari malformation Type I in children: dural graft or sealant?." J Neurosurg Pediatr 8, no. 2 (August 2011): 177-183. Full Text Link to Item
  - Stack, A, Peterson-Carmichael, SL, Yin, DE, Marti, M, Fuchs, H, Jhaveri, R, and Turner, DA. "CA-MRSA brain abscess in a healthy infant." Journal of Pediatric Infectious Diseases 6, no. 1 (2011): 71-75. Full Text
  - Aliabadi, H, Reynolds, R, Powers, CJ, Grant, G, Fuchs, H, and Kurtzberg, J. "Clinical outcome of cerebrospinal fluid shunting for communicating hydrocephalus in mucopolysaccharidoses I, II, and III: a retrospective analysis of 13 patients." Neurosurgery 67, no. 6 (December 2010): 1476-1481. Full Text Link to Item
  - Karikari, IO, Grant, G, Cummings, TJ, Petrella, J, and Fuchs, HE. "Endodermal cyst of the oculomotor nerve." Pediatr Neurosurg 46, no. 2 (August 2010): 155-156. Full Text Link to Item
  - Nimjee, SM, Powers, CJ, McLendon, RE, Grant, GA, and Fuchs, HE. "Single-stage bilateral choroid plexectomy for choroid plexus papilloma in a patient presenting with high cerebrospinal fluid output." J Neurosurg Pediatr 5, no. 4 (April 2010): 342-345. Full Text Link to Item
  - Hughes, BD, Grant, GA, Cummings, TJ, and Fuchs, HE. "Disappearing bone disease and Chiari I malformation." Pediatr Neurosurg 46, no. 1 (2010): 58-61. Full Text Link to Item
  - Aliabadi, H, Miller, J, Radnakrishnan, S, Mehta, AI, Thomas, K, Selznick, L, Goldberg, R, Grant, G, and Fuchs, H. "Spontaneous intrauterine "ping-pong" fracture: review and case illustration." Neuropediatrics 40, no. 2 (April 2009): 73-75. (Review) Full Text Link to Item
  - Waldau, B, Domeshek, LF, Leigh, FA, Lum, KC, Fuchs, HE, Marcus, JR, Mukundan, S, and Grant, GA. "Spontaneous resolution of a 13-mm Chiari malformation Type I in relation to differential growth of the posterior fossa volume." Journal of Neurosurgery. Pediatrics 3, no. 2 (February 2009): 110-114. Full Text
  - Waldau, B, McLendon, RE, Fuchs, HE, George, TM, and Grant, GA. "Few isolated neurons in hypothalamic hamartomas may cause gelastic seizures." Pediatr Neurosurg 45, no. 3 (2009): 225-229. Full Text Link to Item
  - Gururangan, S, Krauser, J, Watral, MA, Driscoll, T, Larrier, N, Reardon, DA, Rich, JN, Quinn, JA, Vredenburgh, JJ, Desjardins, A, McLendon, RE, Fuchs, H, Kurtzberg, J, and Friedman, HS. "Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma." Neuro Oncol 10, no. 5 (October 2008): 745-751. Full Text Link to Item
  - Inman, PC, Mukundan, S, Fuchs, HE, and Marcus, JR. "Craniosynostosis and rickets." Plast Reconstr Surg 121, no. 4 (April 2008): 217e-218e. Full Text Link to Item
  - Waldau, B, Grant, G, and Fuchs, H. "Development of an acquired Chiari malformation Type I in the setting of an untreated lipomyelomeningocele. Case report." J Neurosurg Pediatr 1, no. 2 (February 2008): 164-166. Full Text Link to Item
  - Mukundan, S, Fuchs, H, Alexander, MJ, and Grant, GA. "Dynamic contrast-enhanced magnetic resonance angiography of vascular malformations in pediatric patients. Case report." J Neurosurg 107, no. 3 Suppl (September 2007): 228-231. Full Text Link to Item
  - Rajpal, S, Tubbs, RS, George, T, Oakes, WJ, Fuchs, HE, Hadley, MN, and Iskandar, BJ. "Tethered cord due to spina bifida occulta presenting in adulthood: a tricenter review of 61 patients." J Neurosurg Spine 6, no. 3 (March 2007): 210-215. Full Text Link to Item
  - Powers, CJ, Fuchs, HE, and George, TM. "Chronic subdural hematoma of the neonate: report of two cases and literature review." Pediatric Neurosurgery 43, no. 1 (January 2007): 25-28. (Review) Full Text
  - Powers, CJ, New, KC, McLendon, RE, Friedman, AH, and Fuchs, HE. "Cerebellopontine angle craniopharyngioma: case report and literature review." Pediatric Neurosurgery 43, no. 2 (January 2007): 158-163. (Review) Full Text
  - Wang, PI, Marcus, JR, Fuchs, HE, and Mukundan, S. "Craniosynostosis Secondary to Rickets: Manifestations on Computed Tomography." Radiology Case Reports 2, no. 3 (2007): 43-43. Full Text
  - Powers, CJ, George, T, and Fuchs, HE. "Constipation as a reversible cause of ventriculoperitoneal shunt failure. Report of two cases." Journal of Neurosurgery 105, no. 3 Suppl (September 2006): 227-230. Full Text
  - McGirt, MJ, Nimjee, SM, Fuchs, HE, and George, TM. "Relationship of cine phase-contrast magnetic resonance imaging with outcome after decompression for Chiari I malformations." Neurosurgery 59, no. 1 (July 2006): 140-146. Full Text
  - Mazur, MA, Gururangan, S, Bridge, JA, Cummings, TJ, Mukundan, S, Fuchs, H, Larrier, N, and Halperin, EC. "Intracranial Ewing sarcoma." Pediatr Blood Cancer 45, no. 6 (November 2005): 850-856. Full Text Link to Item
  - Gururangan, S, Hwang, E, Herndon, JE, Fuchs, H, George, T, and Coleman, RE. "[18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma." Neurosurgery 55, no. 6 (December 2004): 1280-1288. Link to Item
  - O'Connell, M, Wong, TZ, Forkheim, KE, Jain, M, Shipes, SW, and Fuchs, HE. "Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump function." Clin Nucl Med 29, no. 9 (September 2004): 578-580. Link to Item
  - Cummings, TJ, George, TM, Fuchs, HE, and McLendon, RE. "The pathology of extracranial scalp and skull masses in young children." Clinical Neuropathology 23, no. 1 (January 2004): 34-43.
  - Gururangan, S, McLaughlin, C, Quinn, J, Rich, J, Reardon, D, Halperin, EC, Herndon, J, Fuchs, H, George, T, Provenzale, J, Watral, M, McLendon, RE, Friedman, A, Friedman, HS, Kurtzberg, J, Vredenbergh, J, and Martin, PL. "High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 21, no. 11 (June 2003): 2187-2191. Full Text
  - Villavicencio, AT, Leveque, J-C, McGirt, MJ, Hopkins, JS, Fuchs, HE, and George, TM. "Comparison of revision rates following endoscopically versus nonendoscopically placed ventricular shunt catheters." Surg Neurol 59, no. 5 (May 2003): 375-379. Link to Item
  - McGirt, MJ, Zaas, A, Fuchs, HE, George, TM, Kaye, K, and Sexton, DJ. "Risk factors for pediatric ventriculoperitoneal shunt infection and predictors of infectious pathogens." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 36, no. 7 (April 2003): 858-862. Full Text
  - McGirt, MJ, Wellons, JC, Nimjee, SM, Bulsara, KR, Fuchs, HE, and George, TM. "Comparison of total versus partial revision of initial ventriculoperitoneal shunt failures." Pediatric Neurosurgery 38, no. 1 (January 2003): 34-40. Full Text
  - McGirt, MJ, Leveque, J-C, Wellons, JC, Villavicencio, AT, Hopkins, JS, Fuchs, HE, and George, TM. "Cerebrospinal fluid shunt survival and etiology of failures: a seven-year institutional experience." Pediatric Neurosurgery 36, no. 5 (May 2002): 248-255. Full Text
  - Bulsara, KR, Zomorodi, AR, Villavicencio, AT, Fuchs, H, and George, TM. "Clinical outcome differences for lipomyelomeningoceles, intraspinal lipomas, and lipomas of the filum terminale." Neurosurg Rev 24, no. 4 (December 2001): 192-194. Link to Item
  - Worley, G, Wiener, JS, George, TM, Fuchs, HE, Mackey, JF, Fitch, RD, and Oldham, KT. "Acute abdominal symptoms and signs in children and young adults with spina bifida: ten years' experience." J Pediatr Surg 36, no. 9 (September 2001): 1381-1386. Full Text Link to Item
  - McLendon, RE, Friedman, HS, Fuchs, HE, Kun, LE, and Bigner, SH. "Diagnostic markers in paediatric medulloblastoma: a Paediatric Oncology Group Study." Histopathology 34, no. 2 (February 1999): 154-162. Full Text
  - Archer, GE, Sampson, JH, McLendon, RE, Friedman, AH, Colvin, OM, Rose, M, Sands, H, McCullough, W, Fuchs, HE, Bigner, DD, and Friedman, HS. "Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats." Journal of Neuro Oncology 44, no. 3 (January 1999): 233-241. Full Text
  - Lee, SE, Johnson, SP, Hale, LP, Li, J, Bullock, N, Fuchs, H, Friedman, A, McLendon, R, Bigner, DD, Modrich, P, and Friedman, HS. "Analysis of DNA mismatch repair proteins in human medulloblastoma." Clin Cancer Res 4, no. 6 (June 1998): 1415-1419. Link to Item
  - Moghrabi, A, Friedman, HS, Ashley, DM, Bottom, KS, Kerby, T, Stewart, E, Bruggers, C, Provenzale, JM, Champagne, M, Hershon, L, Watral, M, Ryan, J, Rasheed, K, Lovell, S, Korones, D, Fuchs, H, George, T, McLendon, RE, Friedman, AH, Buckley, E, and Longee, DC. "Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas." Neurosurg Focus 4, no. 4 (April 15, 1998): e3-. Link to Item
  - McCowage, GB, Friedman, HS, Moghrabi, A, Kerby, T, Ferrell, L, Stewart, E, Duncan-Brown, M, Fuchs, HE, Tien, R, McLendon, RE, Meier, L, Kurtzberg, J, Ashley, D, Colvin, OM, and Longee, DC. "Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas." Med Pediatr Oncol 30, no. 2 (February 1998): 75-80. Link to Item
  - Slavik, T, Bentley, RC, Gray, L, Fuchs, HE, and McLendon, RE. "Solitary fibrous tumor of the meninges occurring after irradiation of a mixed germ cell tumor of the pineal gland." Clin Neuropathol 17, no. 1 (January 1998): 55-60. Link to Item
  - Sampson, JH, Ashley, DM, Archer, GE, Fuchs, HE, Dranoff, G, Hale, LP, and Bigner, DD. "Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion." Neurosurgery 41, no. 6 (December 1997): 1365-1372. Full Text
  - Bigner, SH, McLendon, RE, Fuchs, H, McKeever, PE, and Friedman, HS. "Chromosomal characteristics of childhood brain tumors." Cancer Genet Cytogenet 97, no. 2 (September 1997): 125-134. Link to Item
  - Ashley, DM, Coleman, RE, Fuchs, H, Dear, G, Ginsberg, B, Zalduondo, FM, Friedman, HS, and Longee, D. "Chronic CSF leak into the peritoneal cavity shown by radionuclide cisternography. Successful treatment with an epidural blood patch." Clin Nucl Med 22, no. 6 (June 1997): 390-392. Link to Item
  - Moghrabi, A, Tien, R, Fuchs, H, Longee, D, McLendon, R, and Friedman, HS. "False positive images in the follow-up of patients with brain tumors." Medical and Pediatric Oncology 28, no. 2 (February 1997): 127-131. Full Text
  - Sampson, JH, Archer, GE, Ashley, DM, Fuchs, HE, Hale, LP, Dranoff, G, and Bigner, DD. "Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system." Proceedings of the National Academy of Sciences of the United States of America 93, no. 19 (September 1996): 10399-10404. Full Text
  - McCowage, G, Tien, R, McLendon, R, Felsberg, G, Fuchs, H, Graham, ML, Kurtzberg, J, Moghrabi, A, Ferrell, L, Kerby, T, Duncan-Brown, M, Stewart, E, Robertson, PL, Colvin, OM, Golembe, B, Bigner, DD, and Friedman, HS. "Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide." Medical and Pediatric Oncology 27, no. 1 (July 1996): 32-39. Full Text
  - Ashley, DM, Longee, D, Tien, R, Fuchs, H, Graham, ML, Kurtzberg, J, Casey, J, Olson, J, Meier, L, Ferrell, L, Kerby, T, Duncan-Brown, M, Stewart, E, Colvin, OM, Pipas, JM, McCowage, G, McLendon, R, Bigner, DD, and Friedman, HS. "Treatment of patients with pineoblastoma with high dose cyclophosphamide." Medical and Pediatric Oncology 26, no. 6 (June 1996): 387-392. Full Text
  - Caress, JB, Nohria, V, Fuchs, H, and Boustany, RM. "Torticollis acquired in late infancy due to a cerebellar gangliocytoma." Int J Pediatr Otorhinolaryngol 36, no. 1 (June 1996): 39-44. Link to Item
  - Blaeker, H, Rasheed, BK, McLendon, RE, Friedman, HS, Batra, SK, Fuchs, HE, and Bigner, SH. "Microsatellite analysis of childhood brain tumors." Genes, Chromosomes & Cancer 15, no. 1 (January 1996): 54-63. Full Text
  - Bigner, DD, Archer, GE, McLendon, RE, Friedman, HS, Fuchs, HE, Pai, LH, Herndon, JE, and Pastan, IH. "Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis." Clin Cancer Res 1, no. 12 (December 1995): 1545-1555. Link to Item
  - Lirng, JF, Enterline, DS, Tien, RD, Fuchs, H, Friedman, HS, Ellington, KS, and McLendon, RP. "MRI of papillary meningiomas in children." Pediatr Radiol 25 Suppl 1 (November 1995): S9-13. Link to Item
  - Kurpad, SN, Friedman, HS, Archer, GE, McLendon, RE, Petros, WM, Fuchs, HE, Guaspari, A, and Bigner, DD. "Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats." Cancer Research 55, no. 17 (September 1995): 3803-3809.
  - Moghrabi, A, Fuchs, H, Brown, M, Schold, SC, Graham, M, Kurtzberg, J, Tien, R, Felsberg, G, Lachance, DH, and Colvin, OM. "Cyclophosphamide in combination with sargramostim for treatment of recurrent medulloblastoma." Med Pediatr Oncol 25, no. 3 (September 1995): 190-196. Link to Item
  - Lachance, DH, Oette, D, Schold, SC, Brown, M, Kurtzberg, J, Graham, ML, Tien, R, Felsberg, G, Colvin, OM, and Moghrabi, A. "Dose escalation trial of cyclophosphamide with Sargramostim in the treatment of central nervous system (CNS) neoplasms." Med Pediatr Oncol 24, no. 4 (April 1995): 241-247. Link to Item
  - Pastan, IH, Archer, GE, McLendon, RE, Friedman, HS, Fuchs, HE, Wang, QC, Pai, LH, Herndon, J, and Bigner, DD. "Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model." Proc Natl Acad Sci U S A 92, no. 7 (March 28, 1995): 2765-2769. Link to Item
  - Batra, SK, McLendon, RE, Koo, JS, Castelino-Prabhu, S, Fuchs, HE, Krischer, JP, Friedman, HS, Bigner, DD, and Bigner, SH. "Prognostic implications of chromosome 17p deletions in human medulloblastomas." Journal of Neuro Oncology 24, no. 1 (January 1995): 39-45. Full Text
  - Fuchs, HE, and McLone, DG. "Diagnosis and management of astrocytomas occurring in the posterior fossa." Neurosurgery Quarterly 5, no. 3 (1995): 168-178.
  - Friedman, HS, Archer, GE, McLendon, RE, Schuster, JM, Colvin, OM, Guaspari, A, Blum, R, Savina, PA, Fuchs, HE, and Bigner, DD. "Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats." Cancer Research 54, no. 17 (September 1994): 4710-4714.
  - Halperin, EC, Friedman, HS, Schold, SC, Fuchs, HE, Oakes, WJ, Hockenberger, B, and Burger, PC. "Surgery, hyperfractionated craniospinal irradiation, and adjuvant chemotherapy in the management of supratentorial embryonal neuroepithelial neoplasms in children." Surg Neurol 40, no. 4 (October 1993): 278-283. Link to Item
  - Schuster, JM, Friedman, HS, Archer, GE, Fuchs, HE, McLendon, RE, Colvin, OM, and Bigner, DD. "Intraarterial therapy of human glioma xenografts in athymic rats using 4-hydroperoxycyclophosphamide." Cancer Res 53, no. 10 Suppl (May 15, 1993): 2338-2343. Link to Item
  - Fuchs, HE, Archer, GE, Colvin, OM, Bigner, SH, Schuster, JM, Fuller, GN, Muhlbaier, LH, Schold, SC, Friedman, HS, and Bigner, DD. "Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis." Cancer Research 50, no. 6 (March 1990): 1954-1959.
  - Fuchs, HE, and Bullard, DE. "Immunology of transplantation in the central nervous system." Appl Neurophysiol 51, no. 6 (1988): 278-296. (Review) Link to Item
  - Pizzo, SV, Rajagopalan, S, Roche, PA, Fuchs, HE, Feldman, SR, and Gonias, SL. "Specificity of alpha 2-macroglobulin covalent cross-linking for the active domain of proteinases." Biol Chem Hoppe Seyler 367, no. 11 (November 1986): 1177-1182. Link to Item
  - Hoffman, M, Fuchs, HE, and Pizzo, SV. "The macrophage-mediated regulation of hepatocyte synthesis of antithrombin III and alpha 1-proteinase inhibitor." Thrombosis Research 41, no. 5 (March 1986): 707-715. Full Text
  - Pizzo, SV, Fuchs, HE, Doman, KA, Petruska, DB, and Berger, H. "Release of tissue plasminogen activator and its fast-acting inhibitor in defective fibrinolysis." Arch Intern Med 146, no. 1 (January 1986): 188-191. Link to Item
  - Pizzo, SV, Petruska, DB, Doman, KA, Soong, SJ, and Fuchs, HE. "Releasable vascular plasminogen activator and thrombotic strokes." The American Journal of Medicine 79, no. 4 (October 1985): 407-411. Full Text
  - Fuchs, HE, Berger, H, and Pizzo, SV. "Catabolism of human tissue plasminogen activator in mice." Blood 65, no. 3 (March 1985): 539-544.
  - Fuchs, HE, Trapp, HG, Griffith, MJ, Roberts, HR, and Pizzo, SV. "Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors." The Journal of Clinical Investigation 73, no. 6 (June 1984): 1696-1703. Full Text
  - Fuchs, HE, Michalopoulos, GK, and Pizzo, SV. "Hepatocyte uptake of alpha 1-proteinase inhibitor-trypsin complexes in vitro: evidence for a shared uptake mechanism for proteinase complexes of alpha 1-proteinase inhibitor and antithrombin III." J Cell Biochem 25, no. 4 (1984): 231-243. Full Text Link to Item
  - Fuchs, HE, Shifman, MA, Michalopoulos, G, and Pizzo, SV. "Hepatocyte receptors for antithrombin III-proteinase complexes." Journal of Cellular Biochemistry 24, no. 3 (January 1984): 197-206. Full Text
  - Fuchs, HE, and Pizzo, SV. "Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors." J Clin Invest 72, no. 6 (December 1983): 2041-2049. Full Text Link to Item
  - Gonias, SL, Fuchs, HE, and Pizzo, SV. "A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice." Thrombosis and Haemostasis 48, no. 2 (October 1982): 208-210.
  - Fuchs, HE, Shifman, MA, and Pizzo, SV. "In vivo catabolism of alpha 1-proteinase inhibitor-trypsin, antithrombin III-thrombin and alpha 2-macroglobulin-methylamine." Biochim Biophys Acta 716, no. 2 (May 27, 1982): 151-157. Link to Item
  - Fisher, RG, Woods, NE, Fuchs, HE, and Sweet, RM. "Three-dimensional structures of C-phycocyanin and B-phycoerythrin at 5-A resolution." J Biol Chem 255, no. 11 (June 10, 1980): 5082-5089. Link to Item
  - Sweet, RM, Fuchs, HE, Fisher, RG, and Glazer, AN. "Preliminary crystallographic investigations of two phycobiliproteins." J Biol Chem 252, no. 22 (November 25, 1977): 8258-8260. Link to Item
- Other Articles
  - Rasheed, BK, McLendon, RE, Friedman, HS, Friedman, AH, Fuchs, HE, Bigner, DD, and Bigner, SH. "Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25." Oncogene 10, no. 11 (June 1, 1995): 2243-2246. Link to Item
  - Lee, VS, Provenzale, JM, Fuchs, HE, Osumi, A, and McLendon, RE. "Post-traumatic epidermoid cyst: CT appearance." J Comput Assist Tomogr 19, no. 1 (January 1995): 153-155. Link to Item
  - Furie, DM, Felsberg, GJ, Tien, RD, Friedman, HS, Fuchs, H, and McLendon, R. "MRI of gangliocytoma of cerebellum and spinal cord." Journal of Computer Assisted Tomography 17, no. 3 (May 1993): 488-491.
  - Fuchs, HE, and Pizzo, SV. "Catabolism of antithrombin III-protease complexes." Thromb Res 32, no. 2 (October 15, 1983): 253-254. (Letter) Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles

Other Articles