William J. Fulkerson Jr.

William J. Fulkerson Jr.
Professor of Medicine

Currently I am involved with the NHLBI ARDS Network in research involving acute lung injury and acute respiratory distress syndrome (ARDS). The ARDS Network, composed of Duke and nine other centers, continues the study of mechanical ventilation strategies in patients with severe acute lung injury. Patients are randomized to usual care versus modes of ventilation designed to avoid over distension of the lung. Planning is underway for an additional NHLBI-sponsored randomized trial to examine the role of pulmonary artery catheterization in critically ill patients. Additionally I am involved in clinical trials looking at patients with sepsis, severe respiratory failure, and other common problems in an intensive care unit setting. These investigations concern decision-making, outcome prediction, and cost-effectiveness of care in the intensive care unit.

Key Words include:

1. ARDS
2. Bronchoscopy
3. Critical Care
4. Outcome Predictions
5. Sepsis

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1995

Contact Information

108 Davison Bldg, Durham, NC 27710
Box 3708 Med Ctr, Durham, NC 27710
fulke003@mc.duke.edu (919) 684-1860

Background
Education, Training, & Certifications
- M.D., University of North Carolina at Chapel Hill 1977
Duke Appointment History
- Chief, Division of Pulmonary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1998
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1990 - 1995
Recognition
In the News
- JUL 1, 2014 The News & Observer
  
  Duke Medicine, WakeMed in exploratory talks on collaborating
- OCT 15, 2013 Durham Herald-Sun
  
  New health campaign brings people to their feet
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ackerly, D Clay, Devdutta G. Sangvai, Krishna Udayakumar, Bimal R. Shah, Noah S. Kalman, Alex H. Cho, Kevin A. Schulman, William J. Fulkerson, and Victor J. Dzau. “Training the next generation of physician-executives: an innovative residency pathway in management and leadership.” Acad Med 86, no. 5 (May 2011): 575–79. https://doi.org/10.1097/ACM.0b013e318212e51b.
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  - Halperin, Edward C., William J. Fulkerson, Russel Kaufman, Paul Newman, and Gary L. Stiles. “Should an academic radiation oncologist be allowed to "opt out" of medicare?” J Am Coll Radiol 2, no. 10 (October 2005): 841–45. https://doi.org/10.1016/j.jacr.2005.03.009.
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  - “Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome.” Crit Care Med 30, no. 1 (January 2002): 1–6. https://doi.org/10.1097/00003246-200201000-00001.
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  - Knudsen, N. W., W. J. Fulkerson, and M. W. Sebastian. “Family communication enhanced by 24 hour in house intensivists.” Critical Care Medicine 28, no. 12 (December 1, 2000): A109–A109.
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  - Galanos, A. N., C. F. Pieper, P. S. Kussin, M. T. Winchell, W. J. Fulkerson, F. E. Harrell, J. M. Teno, et al. “Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. SUPPORT Investigators. The Study to Understand Prognoses and Preferences for Outcome and Risks of Treatments.” Crit Care Med 25, no. 12 (December 1997): 1962–68. https://doi.org/10.1097/00003246-199712000-00010.
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  - Fulkerson, W. J., and G. R. Bernard. “Right heart catheterization in acute respiratory failure.” New Horizons (Baltimore, Md.) 5, no. 3 (August 1997): 239–43.
  - “Pulmonary Artery Catheter Consensus conference: consensus statement.” Critical Care Medicine 25, no. 6 (June 1997): 910–25. https://doi.org/10.1097/00003246-199706000-00006.
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  - Teno, J. M., S. Licks, J. Lynn, N. Wenger, A. F. Connors, R. S. Phillips, M. A. O’Connor, et al. “Do advance directives provide instructions that direct care? SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment.” Journal of the American Geriatrics Society 45, no. 4 (April 1997): 508–12. https://doi.org/10.1111/j.1532-5415.1997.tb05179.x.
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  - Bernard, G. R., A. P. Wheeler, J. A. Russell, R. Schein, W. R. Summer, K. P. Steinberg, W. J. Fulkerson, et al. “The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group.” The New England Journal of Medicine 336, no. 13 (March 1997): 912–18. https://doi.org/10.1056/nejm199703273361303.
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  - Connors, A. F., N. V. Dawson, C. Thomas, F. E. Harrell, N. Desbiens, W. J. Fulkerson, P. Kussin, P. Bellamy, L. Goldman, and W. A. Knaus. “Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments).” Am J Respir Crit Care Med 154, no. 4 Pt 1 (October 1996): 959–67. https://doi.org/10.1164/ajrccm.154.4.8887592.
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  - Connors, A. F., T. Speroff, N. V. Dawson, C. Thomas, F. E. Harrell, D. Wagner, N. Desbiens, et al. “The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators.” Jama 276, no. 11 (September 18, 1996): 889–97. https://doi.org/10.1001/jama.276.11.889.
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  - Connors, A. F., N. V. Dawson, N. A. Desbiens, W. J. Fulkerson, L. Goldman, F. E. Harrell, W. A. Knaus, et al. “A controlled trial to improve care for seriously ill hospitalized patients: The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT) (vol 274, pg 1591, 1995).” Jama Journal of the American Medical Association 275, no. 16 (April 24, 1996): 1232–1232.
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  - Schneider, R. F., N. I. Hansen, M. J. Rosen, P. A. Kvale, W. J. Fulkerson, P. Goodman, L. Meiselman, et al. “Lack of usefulness of radiographic screening for pulmonary disease in asymptomatic HIV-infected adults. Pulmonary Complications of HIV Infection Study Group.” Arch Intern Med 156, no. 2 (January 22, 1996): 191–95.
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  - Fulkerson, W. J., N. MacIntyre, J. Stamler, and J. D. Crapo. “Pathogenesis and treatment of the adult respiratory distress syndrome.” Arch Intern Med 156, no. 1 (January 8, 1996): 29–38.
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  - Kussin, P. S., and W. J. Fulkerson. “The rising tide of asthma. Trends in the epidemiology of morbidity and mortality from asthma.” Respir Care Clin N Am 1, no. 2 (December 1995): 163–75.
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  - Connors, Alfred F. “A Controlled Trial to Improve Care for Seriously III Hospitalized Patients.” Jama 274, no. 20 (November 22, 1995): 1591–1591. https://doi.org/10.1001/jama.1995.03530200027032.
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  - TAPSON, V. F., W. J. FULKERSON, and H. A. SALTZMAN. “VENOUS THROMBOEMBOLISM - PREFACE.” Clinics in Chest Medicine 16, no. 2 (June 1, 1995): R11–12.
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  - Knaus, W. A., F. E. Harrell, J. Lynn, L. Goldman, R. S. Phillips, A. F. Connors, N. V. Dawson, et al. “The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults.” Annals of Internal Medicine 122, no. 3 (January 1, 1995): 191–203.
  - Tapson, V. F., and W. J. Fulkerson. “Pulmonary embolism in the intensive care unit.” Journal of Intensive Care Medicine 9, no. 3 (January 1, 1994): 119–31. https://doi.org/10.1177/088506669400900302.
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  - GALANOS, A. N., P. S. KUSSIN, C. F. PIEPER, M. T. WINCHELL, W. J. FULKERSON, R. S. PHILLIPS, A. F. CONNORS, P. M. LAYDE, and J. M. TENO. “THE RELATIONSHIP OF BODY-MASS INDEX TO SUBSEQUENT MORTALITY AMONG SERIOUSLY ILL HOSPITALIZED-PATIENTS.” Clinical Research 41, no. 2 (April 1, 1993): A292–A292.
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  - Pence, J. C., M. A. Deutsch, B. J. Kerns, G. Huper, L. K. Jordan, W. G. Wolfe, W. M. Samuelson, W. J. Fulkerson, R. K. Dodge, and C. A. Plate. “Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma.” Cancer 70, no. 5 (September 1, 1992): 1115–23. https://doi.org/10.1002/1097-0142(19920901)70:5<1115::aid-cncr2820700516>3.0.co;2-q.
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  - Carson, J. L., M. A. Kelley, A. Duff, J. G. Weg, W. J. Fulkerson, H. I. Palevsky, J. S. Schwartz, B. T. Thompson, J. Popovich, and T. E. Hobbins. “The clinical course of pulmonary embolism.” The New England Journal of Medicine 326, no. 19 (May 1992): 1240–45. https://doi.org/10.1056/nejm199205073261902.
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  - CONNORS, A. F., F. E. HARRELL, N. DESBIENS, W. J. FULKERSON, P. KUSSIN, P. E. BELLAMY, and L. GOLDMAN. “CORRELATES OF SURVIVAL-TIME FOLLOWING EXACERBATION OF SEVERE COPD.” Clinical Research 40, no. 2 (April 1, 1992): A372–A372.
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  - CONNORS, A. F., F. E. HARRELL, N. DESBIENS, W. J. FULKERSON, P. KUSSIN, P. E. BELLAMY, and L. GOLDMAN. “CORRELATES OF SURVIVAL-TIME FOLLOWING ACUTE RESPIRATORY-FAILURE.” Clinical Research 40, no. 2 (April 1, 1992): A373–A373.
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  - Fracica, P. J., M. J. Knapp, C. A. Piantadosi, K. Takeda, W. J. Fulkerson, R. E. Coleman, W. G. Wolfe, and J. D. Crapo. “Responses of baboons to prolonged hyperoxia: physiology and qualitative pathology.” J Appl Physiol (1985) 71, no. 6 (December 1991): 2352–62. https://doi.org/10.1152/jappl.1991.71.6.2352.
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  - Cegielski, J. P., and W. J. Fulkerson. “Sarcoidosis presenting as large pulmonary nodules.” North Carolina Medical Journal 52, no. 7 (July 1991): 297–300.
  - Spurney, R. F., W. J. Fulkerson, and S. J. Schwab. “Acute renal failure in critically ill patients: prognosis for recovery of kidney function after prolonged dialysis support.” Crit Care Med 19, no. 1 (January 1991): 8–11. https://doi.org/10.1097/00003246-199101000-00007.
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  - Toscano, J., P. S. Kussin, W. Samuelson, and W. J. Fulkerson. “Pulmonary embolism complicating barbiturate overdose.” Crit Care Med 18, no. 7 (July 1990): 777–78. https://doi.org/10.1097/00003246-199007000-00021.
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  - “Tissue plasminogen activator for the treatment of acute pulmonary embolism. A collaborative study by the PIOPED Investigators.” Chest 97, no. 3 (March 1990): 528–33. https://doi.org/10.1378/chest.97.3.528.
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  - Richards, F. M., and W. J. Fulkerson. “Constrictive pericarditis due to hydralazine-induced lupus erythematosus.” The American Journal of Medicine 88, no. 1N (January 1990): 56N-59N.
  - Shellman, Robert G., and William J. Fulkerson. “The authors reply.” Critical Care Medicine 17, no. 8 (August 1989): 844–844. https://doi.org/10.1097/00003246-198908000-00031.
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  - Shellman, R. G., W. J. Fulkerson, E. DeLong, and C. A. Piantadosi. “Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit.” Crit Care Med 16, no. 7 (July 1988): 671–78. https://doi.org/10.1097/00003246-198807000-00005.
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  - Tabatowski, K., V. L. Roggli, W. J. Fulkerson, R. L. Langley, T. Benning, and W. W. Johnston. “Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation.” Acta Cytol 32, no. 2 (March 1988): 240–46.
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  - Milunski, M. R., H. A. Gallis, and W. J. Fulkerson. “Staphylococcus aureus septicemia mimicking fulminant Rocky Mountain spotted fever.” The American Journal of Medicine 83, no. 4 (October 1987): 801–3. https://doi.org/10.1016/0002-9343(87)90920-x.
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  - Glenny, R. W., W. J. Fulkerson, and C. E. Ravin. “Occult spontaneous esophageal perforation. Unusual clinical and radiographic presentation.” Chest 92, no. 3 (September 1987): 562–65. https://doi.org/10.1378/chest.92.3.562.
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  - Eaton, A. M., H. Serota, G. W. Kernodle, J. P. Uglietta, J. Crawford, and W. J. Fulkerson. “Pulmonary hypertension secondary to serum hyperviscosity in a patient with rheumatoid arthritis.” Am J Med 82, no. 5 (May 1987): 1039–45. https://doi.org/10.1016/0002-9343(87)90172-0.
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  - Gross, M. H., W. J. Fulkerson, and J. O. Moore. “Prevention of amphotericin B-induced rigors by dantrolene.” Arch Intern Med 146, no. 8 (August 1986): 1587–88.
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  - Fulkerson, W. J., R. E. McLendon, and L. R. Prosnitz. “Adult respiratory distress syndrome after limited thoracic radiotherapy.” Cancer 57, no. 10 (May 15, 1986): 1941–46. https://doi.org/10.1002/1097-0142(19860515)57:10<1941::aid-cncr2820571009>3.0.co;2-9.
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  - Fulkerson, W. J., R. E. Coleman, C. E. Ravin, and H. A. Saltzman. “Diagnosis of pulmonary embolism.” Arch Intern Med 146, no. 5 (May 1986): 961–67.
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  - FULKERSON, W. J., E. DELONG, and S. L. YOUNG. “ELDERLY ADMISSIONS TO A MEDICAL ICU - 8 YEAR EXPERIENCE.” American Review of Respiratory Disease 133, no. 4 (April 1, 1986): A351–A351.
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  - FULKERSON, W. J., R. R. MERCER, M. J. KNAPP, K. TAKEDA, P. J. FRACICA, and J. D. CRAPO. “INDICATOR DILUTION LUNG WATER AND PERMEABILITY-SURFACE AREA MEASUREMENTS IN PRIMATES EXPOSED TO HYPEROXIA.” American Review of Respiratory Disease 133, no. 4 (April 1, 1986): A20–A20.
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  - FULKERSON, W. J. “ADULT FOREIGN-BODY ASPIRATION.” Biomedicine & Pharmacotherapy 40, no. 9 (January 1, 1986): 361–361.
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  - Kraus, V. B., W. J. Fulkerson, M. A. Gowen, and W. M. Samuelson. “Straw lung.” N Engl J Med 312, no. 14 (April 4, 1985): 924. https://doi.org/10.1056/nejm198504043121419.
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  - Nolan, J. J. “Fiberoptic bronchoscopy.” The New England Journal of Medicine 311, no. 22 (November 1984): 1443–44. https://doi.org/10.1056/nejm198411293112219.
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  - Fulkerson, W. J. “Current concepts. Fiberoptic bronchoscopy.” The New England Journal of Medicine 311, no. 8 (August 1984): 511–15. https://doi.org/10.1056/nejm198408233110806.
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- Conference Papers
  - Acute Respiratory Distress Syndrome Network, C. L., Roy G. Brower, Michael A. Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, and Arthur Wheeler. “Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.” In The New England Journal of Medicine, 342:1301–8, 2000. https://doi.org/10.1056/nejm200005043421801.
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  - Cooper, G. S., P. Bellamy, N. V. Dawson, N. Desbiens, W. J. Fulkerson, L. Goldman, L. M. Quinn, T. Speroff, and C. S. Landefeld. “A prognostic model for patients with end-stage liver disease.” In Gastroenterology, 113:1278–88, 1997. https://doi.org/10.1053/gast.1997.v113.pm9322523.
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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Publications

Academic Articles

Conference Papers