William J. Fulkerson Jr.

William J. Fulkerson Jr.
Professor of Medicine

Currently I am involved with the NHLBI ARDS Network in research involving acute lung injury and acute respiratory distress syndrome (ARDS). The ARDS Network, composed of Duke and nine other centers, continues the study of mechanical ventilation strategies in patients with severe acute lung injury. Patients are randomized to usual care versus modes of ventilation designed to avoid over distension of the lung. Planning is underway for an additional NHLBI-sponsored randomized trial to examine the role of pulmonary artery catheterization in critically ill patients. Additionally I am involved in clinical trials looking at patients with sepsis, severe respiratory failure, and other common problems in an intensive care unit setting. These investigations concern decision-making, outcome prediction, and cost-effectiveness of care in the intensive care unit.

Key Words include:

1. ARDS
2. Bronchoscopy
3. Critical Care
4. Outcome Predictions
5. Sepsis

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1995

Contact Information

108 Davison Bldg, Durham, NC 27710
Box 3708 Med Ctr, Durham, NC 27710
fulke003@mc.duke.edu (919) 684-1860

Background
Education, Training, & Certifications
- M.D., University of North Carolina at Chapel Hill 1977
Duke Appointment History
- Chief, Division of Pulmonary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1998
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1990 - 1995
Recognition
In the News
- JUL 1, 2014 The News & Observer
  
  Duke Medicine, WakeMed in exploratory talks on collaborating
- OCT 15, 2013 Durham Herald-Sun
  
  New health campaign brings people to their feet
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ackerly, DC, Sangvai, DG, Udayakumar, K, Shah, BR, Kalman, NS, Cho, AH, Schulman, KA, Fulkerson, WJ, and Dzau, VJ. "Training the next generation of physician-executives: an innovative residency pathway in management and leadership." Academic Medicine : Journal of the Association of American Medical Colleges 86, no. 5 (May 2011): 575-579. (Review) Full Text
  - Halperin, EC, Fulkerson, WJ, Kaufman, R, Newman, P, and Stiles, GL. "Should an academic radiation oncologist be allowed to "opt out" of medicare?." J Am Coll Radiol 2, no. 10 (October 2005): 841-845. (Review) Full Text Link to Item
  - Halperin, EC, Fulkerson, WJ, Kaufman, R, Newman, P, and Stiles, GL. "Should an academic radiation oncologist be allowed to "opt out" of Medicare?." Journal of the American College of Radiology 2, no. 10 (2005): 841-845. (Review) Full Text
  - Wiedemann, HP, Arroliga, AC, Komara, J, Denver, VA, Welsh, C, Jr, WJF, MacIntyre, N, Mallatratt, L, Sebastian, M, Sladen, R, Wilcox, C, Brower, RG, Thompson, D, Morris, AH, Clemmer, T, Davis, R, Jr, JO, Lawton, CB, D'Hulst, J, Smith, C, Jefferson, T, Gottlieb, J, Girod, A, Matthay, MA, Daniel, B, Kallet, R, Luce, JM, Gryzner, MA, Abraham, E, Piedalue, F, Kalous, D, Walberg, C, Lockrem, J, McIntyre, R, Parsons, P, Stevens, C, Silverman, HJ, Corral, W, Toews, GB, Arnoldi, D, and Bartlett, RH et al. "Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome." Critical Care Medicine 30, no. 1 (2002): 1-6.
  - Knudsen, NW, Fulkerson, WJ, and Sebastian, MW. "Family communication enhanced by 24 hour in house intensivists." CRITICAL CARE MEDICINE 28, no. 12 (December 2000): A109-A109. Link to Item
  - Galanos, AN, Pieper, CF, Kussin, PS, Winchell, MT, Fulkerson, WJ, Harrell, FE, Teno, JM, Layde, P, Connors, AF, Phillips, RS, and Wenger, NS. "Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. SUPPORT Investigators. The Study to Understand Prognoses and Preferences for Outcome and Risks of Treatments." Crit Care Med 25, no. 12 (December 1997): 1962-1968. Link to Item
  - Galanos, AN, Pieper, CF, Kussin, PS, Winchell, MT, Fulkerson, WJ, Harrell, FE, Teno, JM, Layde, P, Connors, AF, Phillips, RS, and Wenger, NS. "Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients." Critical Care Medicine 25, no. 12 (December 1, 1997): 1962-1968. Full Text
  - Fulkerson, WJ, and Bernard, GR. "Right heart catheterization in acute respiratory failure." New Horiz 5, no. 3 (August 1997): 239-243. (Review) Link to Item
  - "Pulmonary Artery Catheter Consensus conference: consensus statement." Critical Care Medicine 25, no. 6 (June 1997): 910-925. (Review)
  - Teno, JM, Licks, S, Lynn, J, Wenger, N, Connors, AF, Phillips, RS, OConnor, MA, Murphy, DP, Fulkerson, WJ, Desbiens, N, and Knaus, WA. "Do advance directives provide instructions that direct care?." JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 45, no. 4 (April 1997): 508-512. Full Text Link to Item
  - Bernard, GR, Wheeler, AP, Russell, JA, Schein, R, Summer, WR, Steinberg, KP, Fulkerson, WJ, Wright, PE, Christman, BW, Dupont, WD, Higgins, SB, and Swindell, BB. "The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group." The New England Journal of Medicine 336, no. 13 (March 1997): 912-918. Full Text
  - Connors, AF, Dawson, NV, Thomas, C, Harrell, FE, Desbiens, N, Fulkerson, WJ, Kussin, P, Bellamy, P, Goldman, L, and Knaus, WA. "Outcomes following acute exacerbation of severe chronic obstructive lung disease." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 154, no. 4 (October 1996): 959-967. Full Text Link to Item
  - Connors, AF, Speroff, T, Dawson, NV, Thomas, C, Harrell, FE, Wagner, D, Desbiens, N, Goldman, L, Wu, AW, Califf, RM, Fulkerson, WJ, Vidaillet, H, Broste, S, Bellamy, P, Lynn, J, and Knaus, WA. "The effectiveness of right heart catheterization in the initial care of critically ill patients." Journal of the American Medical Association 276, no. 11 (September 18, 1996): 889-897. Full Text
  - Connors, AF, Dawson, NV, Desbiens, NA, Fulkerson, WJ, Goldman, L, Harrell, FE, Knaus, WA, Lynn, J, Oye, RK, Phillips, RS, Teno, J, and Wenger, NS. "A controlled trial to improve care for seriously ill hospitalized patients: The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT) (vol 274, pg 1591, 1995)." JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 275, no. 16 (April 24, 1996): 1232-1232. Link to Item
  - Fulkerson, WJ, MacIntyre, N, Stamler, J, and Crapo, JD. "Pathogenesis and treatment of the adult respiratory distress syndrome." Arch Intern Med 156, no. 1 (January 8, 1996): 29-38. (Review) Link to Item
  - Schneider, RF, Hansen, NI, Rosen, MJ, Kvale, PA, Fulkerson, WJ, Goodman, P, Meiselman, L, Glassroth, J, Reichman, LB, Wallace, JM, and Hopewell, PC. "Lack of usefulness of radiographic screening for pulmonary disease in asymptomatic HIV-infected adults. Pulmonary Complications of HIV Infection Study Group." Archives of Internal Medicine 156, no. 2 (January 1996): 191-195. Full Text
  - Kussin, PS, and Fulkerson, WJ. "The rising tide of asthma. Trends in the epidemiology of morbidity and mortality from asthma." Respir Care Clin N Am 1, no. 2 (December 1995): 163-175. (Review) Link to Item
  - KNAUS, WA, CONNORS, AF, DAWSON, NV, DESBIENS, NA, FULKERSON, WJ, GOLDMAN, L, LYNN, J, OYE, RK, BERGNER, M, DAMIANO, A, HAKIM, R, MURPHY, DJ, TENO, J, VIRNIG, B, WAGNER, DP, WU, AW, YASUI, Y, ROBINSON, DK, KRELING, B, DULAC, J, BAKER, R, HOLAYEL, S, MEEKS, T, MUSTAFA, M, VEGARRA, J, ALZOLA, C, HARRELL, FE, COOK, EF, HAMEL, MB, PETERSON, L, PHILLIPS, RS, TSEVAT, J, FORROW, L, LESKY, L, DAVIS, R, KRESSIN, N, SOLZAN, J, PUOPOLO, AL, BARRETT, LQ, BUCKO, N, BROWN, D, BURNS, M, FOSKETT, C, HOZID, A, KEOHANE, C, MARTINEZ, C, MCWEENEY, D, MELIA, D, OTTO, S, SHEEHAN, K, SMITH, A, TOFIAS, L, ARTHUR, B, COLLINS, C, CUNNION, M, DYER, D, KULAK, C, MICHAELS, M, OKEEFE, M, PARKER, M, TUCHIN, L, WAX, D, WELD, D, HILTUNEN, L, MARKS, G, MAZZAPICA, N, MEDICH, C, SOUKUP, J, CALIFF, RM, GALANOS, AN, KUSSIN, P, MUHLBAIER, LH, WINCHELL, M, MALLATRATT, L, AKIN, E, BELCHER, L, BULLER, E, CLAIR, E, DREW, L, FOGELMAN, L, FRYE, D, FRAULO, B, GESSNER, D, HAMILTON, J, KRUSE, K, LANDIS, D, NOBLES, L, OLIVERIO, R, WHEELER, C, BANKS, N, BERRY, S, CLAYTON, M, HARTWELL, P, HUBBARD, N, KUSSIN, I, NORMAN, B, NOVEAU, J, READ, H, WARREN, B, CASTLE, J, TURNER, K, PERDUE, R, COULTON, C, LANDEFELD, CS, SPEROFF, T, YOUNGNER, S, LENNARD, MJ, NACCARATTO, M, ROACH, MJ, BLINKHORN, M, CORRIGAN, C, GERIC, E, HAAS, L, HARN, J, JERDONEK, J, LANDY, M, MARINO, E, OLESEN, P, PATSKE, S, REPAS, L, SCHNEEBERGER, K, SMITH, C, TYLER, C, ZENCZAK, M, ANDERSON, H, CAROLIN, P, JOHNSON, C, LEONARD, P, LEUENBERGER, J, PALOTTA, L, WARREN, M, FINLEY, J, ROSS, T, SOLEM, G, ZRONEK, S, DAVIS, S, BROSTE, S, LAYDE, P, KRYDA, M, REDING, DJ, VIDAILLET, HJ, FOLLEN, M, MOWERY, P, BACKUS, BE, KEMPF, DL, KUPFER, JM, MAASSEN, KE, ROHDE, JM, WILKE, NL, WILKE, SM, ALBEE, EA, BACKUS, B, FRANZ, AM, HENSELER, DL, HERR, JA, LEICK, I, LEZOTTE, CL, MEDDAUGH, L, DUFFY, L, JOHNSON, D, KRONENWETTER, S, MERKEL, A, BELLAMY, PE, HIATT, J, WENGER, NS, LEALSOTELO, M, MORANVILLEHAWKINS, D, SHEEHAN, P, WATANABE, D, YAMAMOTO, MC, ADEMA, A, ADKINS, E, BECKSON, AM, CARTER, M, DUERR, E, ELHADAD, A, FARBER, A, JACKSON, A, JUSTICE, J, OMEARA, A, BENSON, L, CHENEY, L, MEDINA, C, MORIARTY, J, BAKER, K, MARSDEN, C, WATNE, K, GOYA, D, CARPENTER, CCJ, CARSON, RA, DETMER, DE, STEINWACHS, DE, MOR, V, HAROOTYAN, RA, LEAF, A, WATTS, R, WILLIAMS, S, and RANSOHOFF, D. "A CONTROLLED TRIAL TO IMPROVE CARE FOR SERIOUSLY ILL HOSPITALIZED-PATIENTS - THE STUDY TO UNDERSTAND PROGNOSES AND PREFERENCES FOR OUTCOMES AND RISKS OF TREATMENTS (SUPPORT)." Jama Journal of the American Medical Association 274, no. 20 (November 22, 1995): 1591-1598. (Academic Article) Link to Item
  - TAPSON, VF, FULKERSON, WJ, and SALTZMAN, HA. "VENOUS THROMBOEMBOLISM - PREFACE." CLINICS IN CHEST MEDICINE 16, no. 2 (June 1995): R11-R12. Link to Item
  - Knaus, WA, Harrell, FE, Lynn, J, Goldman, L, Phillips, RS, Connors, AF, Dawson, NV, Fulkerson, WJ, Califf, RM, Desbiens, N, Layde, P, Oye, RK, Bellamy, PE, Hakim, RB, and Wagner, DP. "The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults." Annals of Internal Medicine 122, no. 3 (January 1, 1995): 191-203.
  - Tapson, VF, and Fulkerson, WJ. "Pulmonary embolism in the intensive care unit." Journal of Intensive Care Medicine 9, no. 3 (January 1, 1994): 119-131. (Review) Full Text
  - GALANOS, AN, KUSSIN, PS, PIEPER, CF, WINCHELL, MT, FULKERSON, WJ, PHILLIPS, RS, CONNORS, AF, LAYDE, PM, and TENO, JM. "THE RELATIONSHIP OF BODY-MASS INDEX TO SUBSEQUENT MORTALITY AMONG SERIOUSLY ILL HOSPITALIZED-PATIENTS." CLINICAL RESEARCH 41, no. 2 (April 1993): A292-A292. Link to Item
  - Pence, JC, Deutsch, MA, Kerns, BJ, Huper, G, Jordan, LK, Wolfe, WG, Samuelson, WM, Fulkerson, WJ, Dodge, RK, and Plate, CA. "Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma." Cancer 70, no. 5 (September 1, 1992): 1115-1123. Link to Item
  - Carson, JL, Kelley, MA, Duff, A, Weg, JG, Fulkerson, WJ, Palevsky, HI, Schwartz, JS, Thompson, BT, Popovich, J, and Hobbins, TE. "The clinical course of pulmonary embolism." The New England Journal of Medicine 326, no. 19 (May 1992): 1240-1245. Full Text
  - CONNORS, AF, HARRELL, FE, DESBIENS, N, FULKERSON, WJ, KUSSIN, P, BELLAMY, PE, and GOLDMAN, L. "CORRELATES OF SURVIVAL-TIME FOLLOWING EXACERBATION OF SEVERE COPD." CLINICAL RESEARCH 40, no. 2 (April 1992): A372-A372. Link to Item
  - CONNORS, AF, HARRELL, FE, DESBIENS, N, FULKERSON, WJ, KUSSIN, P, BELLAMY, PE, and GOLDMAN, L. "CORRELATES OF SURVIVAL-TIME FOLLOWING ACUTE RESPIRATORY-FAILURE." CLINICAL RESEARCH 40, no. 2 (April 1992): A373-A373. Link to Item
  - Fracica, PJ, Knapp, MJ, Piantadosi, CA, Takeda, K, Fulkerson, WJ, Coleman, RE, Wolfe, WG, and Crapo, JD. "Responses of baboons to prolonged hyperoxia: physiology and qualitative pathology." Journal of Applied Physiology (Bethesda, Md. : 1985) 71, no. 6 (December 1991): 2352-2362. Full Text
  - Cegielski, JP, and Fulkerson, WJ. "Sarcoidosis presenting as large pulmonary nodules." N C Med J 52, no. 7 (July 1991): 297-300. Link to Item
  - Spurney, RF, Fulkerson, WJ, and Schwab, SJ. "Acute renal failure in critically ill patients: prognosis for recovery of kidney function after prolonged dialysis support." Crit Care Med 19, no. 1 (January 1991): 8-11. Link to Item
  - Toscano, J, Kussin, PS, Samuelson, W, and Fulkerson, WJ. "Pulmonary embolism complicating barbiturate overdose." Crit Care Med 18, no. 7 (July 1990): 777-778. Link to Item
  - "Tissue plasminogen activator for the treatment of acute pulmonary embolism. A collaborative study by the PIOPED Investigators." Chest 97, no. 3 (March 1990): 528-533.
  - Richards, FM, and Fulkerson, WJ. "Constrictive pericarditis due to hydralazine-induced lupus erythematosus." Am J Med 88, no. 1N (January 1990): 56N-59N. Link to Item
  - SHELLMAN, RG, FULKERSON, WJ, and PIANTADOSI, CA. "PROGNOSIS OF PATIENTS WITH CIRRHOSIS AND CHRONIC LIVER-DISEASE ADMITTED TO THE MEDICAL INTENSIVE-CARE UNIT - REPLY." CRITICAL CARE MEDICINE 17, no. 8 (August 1989): 844-844. Full Text Link to Item
  - Shellman, RG, Fulkerson, WJ, DeLong, E, and Piantadosi, CA. "Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit." Critical Care Medicine 16, no. 7 (July 1988): 671-678.
  - Tabatowski, K, Roggli, VL, Fulkerson, WJ, Langley, RL, Benning, T, and Johnston, WW. "Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation." Acta Cytol 32, no. 2 (March 1988): 240-246. Link to Item
  - Milunski, MR, Gallis, HA, and Fulkerson, WJ. "Staphylococcus aureus septicemia mimicking fulminant Rocky Mountain spotted fever." Am J Med 83, no. 4 (October 1987): 801-803. Link to Item
  - Glenny, RW, Fulkerson, WJ, and Ravin, CE. "Occult spontaneous esophageal perforation. Unusual clinical and radiographic presentation." Chest 92, no. 3 (September 1987): 562-565. Link to Item
  - Eaton, AM, Serota, H, Kernodle, GW, Uglietta, JP, Crawford, J, and Fulkerson, WJ. "Pulmonary hypertension secondary to serum hyperviscosity in a patient with rheumatoid arthritis." Am J Med 82, no. 5 (May 1987): 1039-1045. Link to Item
  - Fulkerson, WJ, McLendon, RE, and Prosnitz, LR. "Adult respiratory distress syndrome after limited thoracic radiotherapy." Cancer 57, no. 10 (May 15, 1986): 1941-1946. Link to Item
  - Fulkerson, WJ, Coleman, RE, Ravin, CE, and Saltzman, HA. "Diagnosis of pulmonary embolism." Archives of Internal Medicine 146, no. 5 (May 1986): 961-967. (Review) Full Text
  - FULKERSON, WJ, DELONG, E, and YOUNG, SL. "ELDERLY ADMISSIONS TO A MEDICAL ICU - 8 YEAR EXPERIENCE." AMERICAN REVIEW OF RESPIRATORY DISEASE 133, no. 4 (April 1986): A351-A351. Link to Item
  - FULKERSON, WJ, MERCER, RR, KNAPP, MJ, TAKEDA, K, FRACICA, PJ, and CRAPO, JD. "INDICATOR DILUTION LUNG WATER AND PERMEABILITY-SURFACE AREA MEASUREMENTS IN PRIMATES EXPOSED TO HYPEROXIA." AMERICAN REVIEW OF RESPIRATORY DISEASE 133, no. 4 (April 1986): A20-A20. Link to Item
  - FULKERSON, WJ. "ADULT FOREIGN-BODY ASPIRATION." BIOMEDICINE & PHARMACOTHERAPY 40, no. 9 (1986): 361-361. Link to Item
  - Gross, MH, Fulkerson, WJ, and Moore, JO. "Prevention of amphotericin B-induced rigors by dantrolene." Archives of Internal Medicine 146, no. 8 (1986): 1587-1588.
  - Kraus, VB, Fulkerson, WJ, Gowen, MA, and Samuelson, WM. "Straw lung." N Engl J Med 312, no. 14 (April 4, 1985): 924-. (Letter) Link to Item
  - Fulkerson, WJ. "Fiberoptic Bronchoscopy." New England Journal of Medicine 311, no. 8 (August 23, 1984): 511-515. (Review) Full Text
  - FULKERSON, WJ. "CURRENT CONCEPTS - FIBEROPTIC BRONCHOSCOPY." NEW ENGLAND JOURNAL OF MEDICINE 311, no. 8 (1984): 511-515. Full Text Link to Item
  - FULKERSON, WJ. "FIBEROPTIC BRONCHOSCOPY - REPLY." NEW ENGLAND JOURNAL OF MEDICINE 311, no. 22 (1984): 1443-1444. Link to Item
- Conference Papers
  - Acute Respiratory Distress Syndrome Network, , Brower, RG, Matthay, MA, Morris, A, Schoenfeld, D, Thompson, BT, and Wheeler, A. "Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome." May 2000. Full Text
  - Cooper, GS, Bellamy, P, Dawson, NV, Desbiens, N, Fulkerson, WJ, Goldman, L, Quinn, LM, Speroff, T, and Landefeld, CS. "A prognostic model for patients with end-stage liver disease." October 1997. Full Text Link to Item

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Publications

Academic Articles

Conference Papers