Gayani Tillekeratne | Scholars@Duke

Gayani Tillekeratne
Assistant Professor of Medicine

Global health
Antimicrobial resistance/ stewardship
Acute respiratory tract infections
Emerging infections/ dengue

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2021
Assistant Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2015

Contact Information

310 Trent Drive #213, Durham, NC 27705
gayani.tillekeratne@duke.edu (919) 681-7516

Background
Education, Training, & Certifications
- Global Health Fellowship, Duke University School of Medicine 2012 - 2015
- M.Sc., Duke University 2014
- Infectious Diseases Fellowship, Medicine, University of Pennsylvania 2010 - 2012
- Internal Medicine Residency, Medicine, University of Pennsylvania 2007 - 2010
- M.D., Duke University School of Medicine 2007
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2017 - 2020
- Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2015 - 2017
Recognition
In the News
- DEC 10, 2018 Duke Global Health Initiative
  
  A Century Later: Are We Better Prepared For the Next Influenza Pandemic?
- APR 20, 2016
  
  Technology Enables DGHI Professors To Teach Across the World
Expertise
Global Scholarship
- Research
  - Sri Lanka (Country)
Research
Selected Grants
- RADx-UP CDCC awarded by National Institutes of Health 2020 - 2024
- RAPID: Poirot: From Contact Tracing to Private Exposure Detection awarded by National Science Foundation 2020 - 2022
- Novel Diagnostics to Improve Antimicrobial Stewardship for Acute Respiratory Tract Infections in Resource-Limited Settings awarded by National Institutes of Health 2017 - 2022
- Mapping Epigenetic Memory of Exposure New To Observe (MEMENTO) awarded by Defense Advanced Research Projects Agency 2019 - 2021
- ACTIV-1 awarded by Technical Resources International 2020 - 2021
- Acute Lower Respirator Tract with Lung Ultrasound awarded by Thrasher Research Fund 2018 - 2020
External Relationships
- FHI Clinical
- Faculty of Medicine, University of Ruhuna, Sri Lanka
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Meredith, Hannah R., Sarath Kularatna, Kristin Nagaro, Ajith Nagahawatte, Champica Bodinayake, Ruvini Kurukulasooriya, Nishadhi Wijesingha, et al. “Colonization with multidrug-resistant Enterobacteriaceae among infants: an observational study in southern Sri Lanka.” Antimicrob Resist Infect Control 10, no. 1 (April 30, 2021): 72. https://doi.org/10.1186/s13756-021-00938-3.
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  - Rolfe, Robert, Charles Kwobah, Florida Muro, Anushka Ruwanpathirana, Furaha Lyamuya, Champica Bodinayake, Ajith Nagahawatte, et al. “Barriers to implementing antimicrobial stewardship programs in three low- and middle-income country tertiary care settings: findings from a multi-site qualitative study.” Antimicrob Resist Infect Control 10, no. 1 (March 25, 2021): 60. https://doi.org/10.1186/s13756-021-00929-4.
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  - Zhang, Helen L., Champica Bodinayake, Gaya B. Wijayaratne, Pasangi Jayatissa, DL Bhagya Piyasiri, Ruvini Kurukulasooriya, Tianchen Sheng, Ajith Nagahawatte, Christopher Woods, and L Gayani Tillekeratne. “Point-prevalence survey of outpatient antibiotic prescription at a tertiary medical center in Sri Lanka: opportunities to improve prescribing practices for respiratory illnesses.” Bmc Infect Dis 21, no. 1 (January 21, 2021): 97. https://doi.org/10.1186/s12879-021-05804-6.
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  - Vanderburg, Sky, Gaya Wijayaratne, Nayomi Danthanarayana, Jude Jayamaha, Bhagya Piyasiri, Chathurangi Halloluwa, Tianchen Sheng, et al. “Outbreak of severe acute respiratory infection in Southern Province, Sri Lanka in 2018: a cross-sectional study.” Bmj Open 10, no. 11 (November 6, 2020): e040612. https://doi.org/10.1136/bmjopen-2020-040612.
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  - Shoff, Christopher J., Mary L. Townsend, L Gayani Tillekeratne, Ryan D. Schulteis, Michael E. Yarrington, Nicholas A. Turner, Christopher W. Woods, and Christopher J. Hostler. “Improved empiric antibiotic prescribing for acute cystitis with use of local urinary antibiogram and clinical decision support system.” Infect Control Hosp Epidemiol 41, no. 11 (November 2020): 1351–53. https://doi.org/10.1017/ice.2020.357.
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  - Tillekeratne, L Gayani, Sunil Suchindran, Emily R. Ko, Elizabeth A. Petzold, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.” Open Forum Infect Dis 7, no. 6 (June 2020): ofaa194. https://doi.org/10.1093/ofid/ofaa194.
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  - Li, You, Rachel M. Reeves, Xin Wang, Quique Bassat, W Abdullah Brooks, Cheryl Cohen, David P. Moore, et al. “Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis.” Lancet Glob Health 7, no. 8 (August 2019): e1031–45. https://doi.org/10.1016/S2214-109X(19)30264-5.
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  - Tillekeratne, L Gayani, Champica K. Bodinayake, Ryan Simmons, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachchi, Bradly P. Nicholson, et al. “Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka.” Am J Trop Med Hyg 100, no. 3 (March 2019): 672–80. https://doi.org/10.4269/ajtmh.18-0699.
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  - Sheng, Tianchen, Gaya B. Wijayaratne, Thushani M. Dabrera, Richard J. Drew, Ajith Nagahawatte, Champica K. Bodinayake, Ruvini Kurukulasooriya, et al. “Point-prevalence study of antimicrobial use in public hospitals in southern Sri Lanka identifies opportunities for improving prescribing practices.” Infect Control Hosp Epidemiol 40, no. 2 (February 2019): 224–27. https://doi.org/10.1017/ice.2018.321.
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  - Tillekeratne, L Gayani, Champica Bodinayake, Ajith Nagahawatte, Ruvini Kurukulasooriya, Lori A. Orlando, Ryan A. Simmons, Lawrence P. Park, Christopher W. Woods, and Shelby D. Reed. “Use of clinical algorithms and rapid influenza testing to manage influenza-like illness: a cost-effectiveness analysis in Sri Lanka.” Bmj Glob Health 4, no. 2 (2019): e001291. https://doi.org/10.1136/bmjgh-2018-001291.
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  - Bodinayake, Champica K., L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachchi, John J. Strouse, October M. Sessions, et al. “Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic.” Plos Negl Trop Dis 12, no. 2 (February 2018): e0006258. https://doi.org/10.1371/journal.pntd.0006258.
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  - Shapiro, David, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Ruvini Kurukulasooriya, Jeremy Hsiang, Bradley Nicholson, et al. “Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka.” Am J Trop Med Hyg 97, no. 1 (July 2017): 88–96. https://doi.org/10.4269/ajtmh.17-0032.
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  - Uehara, Anna, Hasitha Aravinda Tissera, Champica K. Bodinayake, Ananda Amarasinghe, Ajith Nagahawatte, L Gayani Tillekeratne, Jie Cui, et al. “Analysis of Dengue Serotype 4 in Sri Lanka during the 2012-2013 Dengue Epidemic.” Am J Trop Med Hyg 97, no. 1 (July 2017): 130–36. https://doi.org/10.4269/ajtmh.16-0540.
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  - Tillekeratne, L Gayani, Champica K. Bodinayake, Thushani Dabrera, Ajith Nagahawatte, Wasantha Kodikara Arachchi, Anoji Sooriyaarachchi, Kearsley Stewart, Melissa Watt, Truls Østbye, and Christopher W. Woods. “Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians.” Bmc Fam Pract 18, no. 1 (March 16, 2017): 37. https://doi.org/10.1186/s12875-017-0619-z.
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  - Bodinayake, Champica K., L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachichi, John J. Strouse, October M. Sessions, et al. “Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka.” Plos Negl Trop Dis 10, no. 10 (October 2016): e0004995. https://doi.org/10.1371/journal.pntd.0004995.
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  - Dabrera, Thushani Marie Elizabeth, L Gayani Tillekeratne, MS Nilanthi Fernando, ST Kaushlya Kasturiaratchi, and Truls Østbye. “Prevalence and Correlates of Leprosy in a High-Risk Community Setting in Sri Lanka.” Asia Pac J Public Health 28, no. 7 (October 2016): 586–91. https://doi.org/10.1177/1010539516666360.
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  - Tillekeratne, L Gayani, Dhammika Vidanagama, Rashmi Tippalagama, Rashmi Lewkebandara, Maria Joyce, Bradly P. Nicholson, Ajith Nagahawatte, Champica K. Bodinayake, Aruna Dharshan De Silva, and Christopher W. Woods. “Extended-spectrum ß-Lactamase-producing Enterobacteriaceae as a Common Cause of Urinary Tract Infections in Sri Lanka.” Infect Chemother 48, no. 3 (September 2016): 160–65. https://doi.org/10.3947/ic.2016.48.3.160.
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  - Tillekeratne, L Gayani, Champica K. Bodinayake, Ajith Nagahawatte, Dhammika Vidanagama, Vasantha Devasiri, Wasantha Kodikara Arachchi, Ruvini Kurukulasooriya, et al. “Use of Rapid Influenza Testing to Reduce Antibiotic Prescriptions Among Outpatients with Influenza-Like Illness in Southern Sri Lanka.” Am J Trop Med Hyg 93, no. 5 (November 2015): 1031–37. https://doi.org/10.4269/ajtmh.15-0269.
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  - Tillekeratne, L Gayani, Champica K. Bodinayake, Ajith Nagahawatte, Dhammika Vidanagama, Vasantha Devasiri, Wasantha Kodikara Arachchi, Ruvini Kurukulasooriya, et al. “An under-recognized influenza epidemic identified by rapid influenza testing, southern Sri Lanka, 2013.” Am J Trop Med Hyg 92, no. 5 (May 2015): 1023–29. https://doi.org/10.4269/ajtmh.14-0708.
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  - Tillekeratne, L Gayani, Darren R. Linkin, Mariah Obino, Afua Omar, Mary Wanjiku, David Holtzman, and Jennifer Cohn. “A multifaceted intervention to reduce rates of catheter-associated urinary tract infections in a resource-limited setting.” Am J Infect Control 42, no. 1 (January 2014): 12–16. https://doi.org/10.1016/j.ajic.2013.07.007.
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  - Tillekeratne, L. G., S. Feng, W. Schimana, O. O. Johnson, G. D. Kinabo, B. T. Mmbaga, L. J. Msuya, et al. “Identifying HIV-infected children who may benefit from early initiation of antiretrovirals.” Journal of Pediatric Infectious Diseases 4, no. 4 (November 11, 2009): 387–92. https://doi.org/10.3233/JPI-2009-0200.
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  - Johnson, Opemipo O., Daniel K. Benjamin, Werner Schimana, L Gayani Tillekeratne, John A. Crump, Keren Z. Landman, Grace D. Kinabo, et al. “Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern Tanzania.” Pediatr Infect Dis J 28, no. 6 (June 2009): 493–97. https://doi.org/10.1097/INF.0b013e3181950b7f.
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  - Tillekeratne, L. G., N. M. Thielman, R. A. Kiwera, H. Y. Chu, L. Kaale, S. C. Morpeth, J. Ostermann, et al. “Morbidity and mortality among a cohort of HIV-infected adults in a programme for community home-based care, in the Kilimanjaro Region of Tanzania (2003-2005).” Ann Trop Med Parasitol 103, no. 3 (April 2009): 263–73. https://doi.org/10.1179/136485909X398203.
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- Conference Papers
  - Mutucumarana, Charmaine P., Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Ruvini Kurukulasooriya, Thamali Anuradha, Aruna Dharshan De Silva, et al. “Geospatial analysis of dengue emergence in rural areas in the Southern Province of Sri Lanka.” In Trans R Soc Trop Med Hyg, 114:408–14, 2020. https://doi.org/10.1093/trstmh/trz123.
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  - Sheng, Tianchen, Gaya B. Wijayaratne, Thushani M. Dabrera, Richard J. Drew, Ajith Nagahawatte, Champica K. Bodinayake, Ruvini Kurukulasooriya, et al. “URINARY TRACT INFECTION IS A COMMON REASON FOR POTENTIALLY INAPPROPRIATE ANTIMICROBIAL USE AMONG INPATIENTS IN SRI LANKA.” In American Journal of Tropical Medicine and Hygiene, 101:154–154. AMER SOC TROP MED & HYGIENE, 2019.
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  - Tillekeratne, L Gayani, Sunil Suchindran, Emily R. Ko, Elizabeth A. Petzold, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “HOST GENES ARE DIFFERENTIALLY EXPRESSED IN DENGUE COMPARED TO INFLUENZA INFECTIONS.” In American Journal of Tropical Medicine and Hygiene, 101:263–263. AMER SOC TROP MED & HYGIENE, 2019.
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  - Wijayaratne, Weerasinghe M. D. G. B., Champika K. Bodinayake, L Gayani Tillekeratne, Wasantha KodikaraArachchi, Vasantha Devasiri, Truls Ostbye, Ruvini P. Kurukulasooriya, et al. “A COMPARISON BETWEEN IGM-ELISA AND IGM RAPID IMMUNOCHROMATOGRAPHY TEST IN THE DIAGNOSIS OF LEPTOSPIROSIS DURING THE ACUTE PHASE OF ILLNESS IN SOUTHERN SRI LANKA.” In American Journal of Tropical Medicine and Hygiene, 101:338–338. AMER SOC TROP MED & HYGIENE, 2019.
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  - Wijayaratne, Weerasinghe M. D. G. B., Sky Vanderburg, Vasantha Devasiri, Ajith Nagahawatte, Champika K. Bodinayake, Eelizabeth Petzold, Sunethra Gunasena, et al. “AN OUTBREAK OF ADENOVIRUS CAUSING SEVERE RESPIRATORY ILLNESS IN SOUTHERN SRI LANKA, 2018.” In American Journal of Tropical Medicine and Hygiene, 101:175–175. AMER SOC TROP MED & HYGIENE, 2019.
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  - Vanderburg, Sky, Tianchen Sheng, Gaya Wijayaratne, Thushani Dabrera, Champica K. Bodinayake, Ajith Nagahawatte, Ruvini Kurukulasooriya, Richard Drew, Christopher W. Woods, and L Gayani Tillekeratne. “FREQUENT EMPIRIC BROAD-SPECTRUM ANTIMICROBIAL USE AMONG HOSPITALIZED PATIENTS WITH LOWER RESPIRATORY TRACT INFECTION IN SOUTHERN SRI LANKA.” In Respirology, 23:186–87. WILEY, 2018.
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  - Tillekeratne, L., Champica Bodinayake, Ryan Simmons, Ajith Nagahawatte, Vasantha Devasiri, Sky Vanderburg, Ruvini Kurukulasooriya, et al. “ACUTE RESPIRATORY VIRAL INFECTIONS: AN IMPORTANT CAUSE OF ADMISSIONS FOR ACUTE FEBRILE ILLNESS IN THE SOUTHERN PROVINCE, SRI LANKA.” In American Journal of Tropical Medicine and Hygiene, 99:411–411. AMER SOC TROP MED & HYGIENE, 2018.
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  - Tillekeratne, L., Sunil Suchindran, Emily Ko, Elizabeth Petzold, Champica Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “A GENE EXPRESSION SIGNATURE ACCURATELY IDENTIFIES VIRAL ACUTE RESPIRATORY INFECTIONS IN A SRI LANKAN POPULATION.” In American Journal of Tropical Medicine and Hygiene, 99:641–42. AMER SOC TROP MED & HYGIENE, 2018.
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  - Weerasinghe, Nayani, M. Kurukulasooriya, L. Tillekeratne, W. Wijayaratne, Champica Bodinayake, I. Devasiri, Niroshan Dahanayake, et al. “ECONOMIC IMPACT OF DENGUE ON PATIENTS HOSPITALIZED IN SOUTHERN SRI LANKA - AN ANALYSIS OF DIRECT AND INDIRECT COSTS.” In American Journal of Tropical Medicine and Hygiene, 99:438–39. AMER SOC TROP MED & HYGIENE, 2018.
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  - Wijayaratne, W., C. Fonseka, Ajith Nagahawatte, Champica Bodinayake, Nayani Weerasinghe, M. Kurukulasooriya, K. Anuradha, et al. “CLINICAL AND LABORATORY FEATURES ASSOCIATED WITH PROGRESSION TO SEVERE DENGUE AMONG POTENTIALLY HIGH-RISK DENGUE PATIENTS HOSPITALIZED IN SOUTHERN SRI LANKA.” In American Journal of Tropical Medicine and Hygiene, 99:200–200. AMER SOC TROP MED & HYGIENE, 2018.
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  - Bodinayake, Champica K., L Gayani Tillekeratne, Ajith Nagahawatte, Charmaine Mutucumarana, Vasantha Devasiri, Ruvini Kurukulasooriya, Truls Ostbye, Megan E. Reller, and Christopher W. Woods. “THE 2009 WORLD HEALTH ORGANIZATION DENGUE CLASSIFICATION OVER-ESTIMATES DENGUE DISEASE SEVERITY IN SRI LANKA.” In American Journal of Tropical Medicine and Hygiene, 97:361–62. AMER SOC TROP MED & HYGIENE, 2017.
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  - Kurukulasooriya, Ruvini, L Gayani Tillekeratne, WMD Gaya B. Wijayaratne, Champica K. Bodinayake, Malindu D. Rajapakshe, B. G. Umesha, T. D. Abewickrama, et al. “HIGH PREVALENCE OF SUSPECTED NOSOCOMIAL COLONIZATION WITH METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AT A TERTIARY CARE HOSPITAL IN SOUTHERN SRI LANKA.” In American Journal of Tropical Medicine and Hygiene, 97:143–143. AMER SOC TROP MED & HYGIENE, 2017.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Global Scholarship

Research

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Recent Courses