Geoffrey Stuart Pitt | Scholars@Duke

Geoffrey Stuart Pitt
Adjunct Professor in the Department of Medicine

Our research focuses on how intracellular Ca²⁺ , the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca²⁺ influx through voltage-gated Ca²⁺ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca²⁺ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Current Appointments & Affiliations

Adjunct Professor in the Department of Medicine, Medicine, Cardiology, Medicine 2016
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011

Contact Information

Duke Box 103030, Durham, NC 27710
geoffrey.pitt@duke.edu (919) 668-7641
Pitt lab website

Background
Education, Training, & Certifications
- Fellow In Cardiovascular Medicine, Medicine, Stanford University 1995 - 1999
- Medical Resident, Medicine, Stanford University 1993 - 1995
- M.D., Johns Hopkins University 1993
Duke Appointment History
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2007 - 2017
- Professor of Medicine, Medicine, Cardiology, Medicine 2014 - 2016
- Professor of Neurobiology, Neurobiology, Basic Science Departments 2014 - 2016
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2014 - 2016
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2014
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2008 - 2014
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2014
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2007 - 2008
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Fibroblast Growth Factor Homologous Factor Modulation and Effect on Cardiac Ion Channel Trafficking awarded by National Institutes of Health 2016 - 2018
- Bone-targeted calcium channel agonists for osteoporosis awarded by UH Harrington Discovery Institute 2015 - 2017
- Calcium regulation and dysregulation of cardiac ion channels awarded by National Institutes of Health 2008 - 2017
- Calmodulin regulation of Na+ channels in neurons and cardiomyocytes awarded by National Institutes of Health 2014 - 2016
- Structural studies of NaV1.5 and functional implications awarded by National Institutes of Health 2013 - 2016
- Investigation of calcium channel modulation in cardiomyocytes by novel methods awarded by Columbia University 2013 - 2016
- The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
Publications & Artistic Works
Selected Publications
- Books
  - Pitt, GS. Ion Channels in Health and Disease. July 29, 2016. Full Text
- Book Sections
  - Pitt, GS, and Marx, SO. "Calmodulin and CaMKII as Ca<sup>2+</sup> Switches for Cardiac Ion Channels." In Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition, 189-195. January 1, 2013. Full Text
- Conference Papers
  - Zhang, H, Sun, AY, Kim, JJ, Graham, V, Finch, EA, Nepliouev, I, Zhao, G, Li, T, Lederer, WJ, Stiber, JA, Pitt, GS, Bursac, N, and Rosenberg, PB. "STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node." October 2015. Full Text
  - Hennessey, JA, Marcou, CA, Wang, C, Wei, EQ, Wang, C, Crotti, L, Schwartz, P, Ackerman, MJ, and Pitt, GS. "FGF12 is a Novel Brugada Syndrome Locus." November 26, 2013. Link to Item
  - Kumagai, A, Mann, SK, Pupillo, M, Pitt, G, Devreotes, PN, and Firtel, RA. "A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium." January 1988. Full Text
  - Pupillo, M, Klein, P, Vaughan, R, Pitt, G, Lilly, P, Sun, T, Devreotes, P, Kumagai, A, and Firtel, R. "cAMP receptor and G-protein interactions control development in Dictyostelium." January 1988. Full Text
- Journal Articles
  - Katchman, A, Yang, L, Zakharov, SI, Kushner, J, Abrams, J, Chen, B-X, Liu, G, Pitt, GS, Colecraft, HM, and Marx, SO. "Proteolytic cleavage and PKA phosphorylation of α 1C subunit are not required for adrenergic regulation of Ca V 1.2 in the heart." Proceedings of the National Academy of Sciences 114, no. 34 (August 22, 2017): 9194-9199. Full Text
  - Pablo, JL, and Pitt, GS. "Divide, multitask, and conquer: Coordination in channel regulation." Channels 11, no. 4 (July 4, 2017): 268-270. Full Text
  - Wei, EQ, Sinden, DS, Mao, L, Zhang, H, Wang, C, and Pitt, GS. "Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload." Proceedings of the National Academy of Sciences of the United States of America 114, no. 20 (May 2017): E4010-E4019. Full Text
  - Wang, X, Tang, H, Wei, EQ, Wang, Z, Yang, J, Yang, R, Wang, S, Zhang, Y, Pitt, GS, Zhang, H, and Wang, C. "Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles." Journal of molecular and cellular cardiology 104 (March 2017): 63-74. Full Text
  - Yan, H, Wang, C, Marx, SO, and Pitt, GS. "Calmodulin limits pathogenic Na+ channel persistent current." The Journal of general physiology 149, no. 2 (February 2017): 277-293. Full Text
  - Black, JB, Adler, AF, Wang, H-G, D'Ippolito, AM, Hutchinson, HA, Reddy, TE, Pitt, GS, Leong, KW, and Gersbach, CA. "Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells." Cell stem cell 19, no. 3 (September 2016): 406-414. Full Text
  - Pitt, GS, and Lee, S-Y. "Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins." Protein science : a publication of the Protein Society 25, no. 9 (September 2016): 1573-1584. (Review) Full Text
  - Yang, J, Wang, Z, Sinden, DS, Wang, X, Shan, B, Yu, X, Zhang, H, Pitt, GS, and Wang, C. "FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner." Channels (Austin, Tex.) 10, no. 5 (September 2016): 410-420. Full Text
  - Sun, AY, and Pitt, GS. "Long QT Syndrome and Seizures∗." JACC: Clinical Electrophysiology 2, no. 3 (June 2016): 277-278. Full Text
  - Matsui, M, and Pitt, GS. "Genetic variants and disease: correlate or cause?." European heart journal 37, no. 18 (May 2016): 1476-1478. Full Text
  - Pablo, JL, Wang, C, Presby, MM, and Pitt, GS. "Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action." Proceedings of the National Academy of Sciences of the United States of America 113, no. 19 (May 2016): E2665-E2674. Full Text
  - Wang, H-G, Zhu, W, Kanter, RJ, Silva, JR, Honeywell, C, Gow, RM, and Pitt, GS. "A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias." Journal of molecular and cellular cardiology 92 (March 2016): 52-62. Full Text
  - Pablo, JL, and Pitt, GS. "Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease." The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 22, no. 1 (February 2016): 19-25. (Review) Full Text
  - Choi, J-I, Wang, C, Thomas, MJ, and Pitt, GS. "α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current." PloS one 11, no. 3 (January 2016): e0152355-. Full Text
  - Musa, H, Kline, CF, Sturm, AC, Murphy, N, Adelman, S, Wang, C, Yan, H, Johnson, BL, Csepe, TA, Kilic, A, Higgins, RSD, Janssen, PML, Fedorov, VV, Weiss, R, Salazar, C, Hund, TJ, Pitt, GS, and Mohler, PJ. "SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia." Proceedings of the National Academy of Sciences of the United States of America 112, no. 40 (October 2015): 12528-12533. Full Text
  - Pitt, GS. "Cardiovascular precision medicine: hope or hype?." European heart journal 36, no. 29 (August 2015): 1842-1843. Full Text
  - Andersen, ND, Ramachandran, KV, Bao, MM, Kirby, ML, Pitt, GS, and Hutson, MR. "Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow." Journal of molecular and cellular cardiology 80 (March 2015): 1-9. Full Text
  - Chen-Izu, Y, Shaw, RM, Pitt, GS, Yarov-Yarovoy, V, Sack, JT, Abriel, H, Aldrich, RW, Belardinelli, L, Cannell, MB, Catterall, WA, Chazin, WJ, Chiamvimonvat, N, Deschenes, I, Grandi, E, Hund, TJ, Izu, LT, Maier, LS, Maltsev, VA, Marionneau, C, Mohler, PJ, Rajamani, S, Rasmusson, RL, Sobie, EA, Clancy, CE, and Bers, DM. "Na+ channel function, regulation, structure, trafficking and sequestration." The Journal of physiology 593, no. 6 (March 2015): 1347-1360. (Review) Full Text
  - Betzenhauser, MJ, Pitt, GS, and Antzelevitch, C. "Calcium Channel Mutations in Cardiac Arrhythmia Syndromes." Current molecular pharmacology 8, no. 2 (January 2015): 133-142. (Review) Full Text
  - Yang, L, Katchman, A, Weinberg, RL, Abrams, J, Samad, T, Wan, E, Pitt, GS, and Marx, SO. "The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart." The Journal of biological chemistry 290, no. 4 (January 2015): 2166-2174. Full Text
  - Yan, H, Pablo, JL, Wang, C, and Pitt, GS. "FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons." eLife 3 (September 30, 2014): e04193-. Full Text
  - Wang, C, Chung, BC, Yan, H, Wang, H-G, Lee, S-Y, and Pitt, GS. "Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation." Nature communications 5 (September 18, 2014): 4896-. Full Text
  - Abbott, GW, and Pitt, GS. "Ion channels under the sun." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, no. 5 (May 2014): 1957-1962. Full Text
  - Hennessey, JA, Boczek, NJ, Jiang, Y-H, Miller, JD, Patrick, W, Pfeiffer, R, Sutphin, BS, Tester, DJ, Barajas-Martinez, H, Ackerman, MJ, Antzelevitch, C, Kanter, R, and Pitt, GS. "A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis." PloS one 9, no. 9 (January 2014): e106982-. Full Text
  - Hennessey, JA, Marcou, CA, Wang, C, Wei, EQ, Wang, C, Tester, DJ, Torchio, M, Dagradi, F, Crotti, L, Schwartz, PJ, Ackerman, MJ, and Pitt, GS. "FGF12 is a candidate Brugada syndrome locus." Heart Rhythm 10, no. 12 (December 2013): 1886-1894. Full Text Link to Item
  - Hennessey, JA, Jiang, Y, Miller, JD, Stadt, HA, Patrick, W, Pfeiffer, R, Antzelevitch, C, Kanter, R, and Pitt, GS. "A CACNA1C Mutation that Causes a Subset of Timothy Syndrome Phenotypes Correlates." Heart Rhythm 10, no. 11 (November 2013): 1745-. Full Text Link to Item
  - Hennessey, JA, Wei, EQ, and Pitt, GS. "Fibroblast growth factor homologous factors modulate cardiac calcium channels." Circ Res 113, no. 4 (August 2, 2013): 381-388. Full Text Link to Item
  - Yan, H, Pablo, JL, and Pitt, GS. "FGF14 Regulates Presynaptic Ca2+ Channels and Synaptic Transmission." Cell Reports 4, no. 1 (July 11, 2013): 66-75. Full Text
  - Yan, H, Pablo, JL, and Pitt, GS. "FGF14 regulates presynaptic Ca2+ channels and synaptic transmission." Cell Rep 4, no. 1 (July 11, 2013): 66-75. Full Text Link to Item
  - Wang, H-G, He, XP, Li, Q, Madison, RD, Moore, SD, McNamara, JO, and Pitt, GS. "The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability." J Biol Chem 288, no. 19 (May 10, 2013): 13258-13268. Full Text Link to Item
  - Ramachandran, KV, Hennessey, JA, Barnett, AS, Yin, X, Stadt, HA, Foster, E, Shah, RA, Yazawa, M, Dolmetsch, RE, Kirby, ML, and Pitt, GS. "Calcium influx through L-type Ca(V)1.2 Ca2+ channels regulates mandibular development." JOURNAL OF CLINICAL INVESTIGATION 123, no. 4 (April 2013): 1638-1646. Full Text Link to Item
  - Chen, BJ, Jiao, Y, Zhang, P, Sun, AY, Pitt, GS, Deoliveira, D, Drago, N, Ye, T, Liu, C, and Chao, NJ. "Long-term in vivo imaging of multiple organs at the single cell level." PLoS ONE 8, no. 1 (January 2, 2013): e52087-. Full Text
  - Daubert, JP, and Pitt, GS. "Can polymorphisms predict response to antiarrhythmic drugs in atrial fibrillation?." J Am Coll Cardiol 60, no. 6 (August 7, 2012): 546-547. Full Text Link to Item
  - Wang, C, Chung, BC, Yan, H, Lee, S-Y, and Pitt, GS. "Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin." Structure 20, no. 7 (July 3, 2012): 1167-1176. Full Text Link to Item
  - Stephens, SB, Schisler, JC, Hohmeier, HE, An, J, Sun, AY, Pitt, GS, and Newgard, CB. "A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function." Cell metabolism 16, no. 1 (July 2012): 33-43. Full Text
  - Amenta, J, and Pitt, GS. "Novel Roles of Fibroblast Growth Factor Homologous Factors in Heart." BIOPHYSICAL JOURNAL 102, no. 3 (January 31, 2012): 34A-34A. Link to Item
  - Zhong, L, Bellemer, A, Yan, H, Ken, H, Jessica, R, Hwang, RY, Pitt, GS, and Tracey, WD. "Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel." Cell Rep 1, no. 1 (January 26, 2012): 43-55. Full Text Link to Item
  - Lodder, EM, Scicluna, BP, Milano, A, Sun, AY, Tang, H, Remme, CA, Moerland, PD, Tanck, MWT, Pitt, GS, Marchuk, DA, and Bezzina, CR. "Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction." PLoS Genetics 8, no. 12 (January 2012): e1003113-. Full Text
  - Wei, EQ, Barnett, AS, Pitt, GS, and Hennessey, JA. "Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias." Trends Cardiovasc Med 21, no. 7 (October 2011): 199-203. (Review) Full Text Link to Item
  - Wang, C, Hennessey, JA, Kirkton, RD, Wang, C, Graham, V, Puranam, RS, Rosenberg, PB, Bursac, N, and Pitt, GS. "Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts." Circ Res 109, no. 7 (September 16, 2011): 775-782. Full Text Link to Item
  - Wang, C, Wang, C, Hoch, EG, and Pitt, GS. "Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels." J Biol Chem 286, no. 27 (July 8, 2011): 24253-24263. Full Text Link to Item
  - Sun, AY, Koontz, JI, Shah, SH, Piccini, JP, Nilsson, KR, Craig, D, Haynes, C, Gregory, SG, Hranitzky, PM, and Pitt, GS. "The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction." Circ Cardiovasc Genet 4, no. 2 (April 2011): 163-168. Full Text Link to Item
  - Sun, AY, and Pitt, GS. "Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation." Heart rhythm 8, no. 4 (April 2011): 631-633. Full Text
  - Wang, H-G, Wang, C, and Pitt, GS. "Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents." PLoS One 6, no. 9 (2011): e25741-. Full Text Link to Item
  - Amenta, JJ, and Pitt, GS. "The glitter of gold: Biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method"." American Journal of Physiology - Cell Physiology 298, no. 6 (2010): C1305-C1307. Full Text
  - Koontz, JI, Haithcock, D, Cumbea, V, Waldron, A, Stricker, K, Hughes, A, Nilsson, K, Sun, A, Piccini, JP, Kraus, WE, Pitt, GS, Shah, SH, and Hranitzky, P. "Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository." Am Heart J 158, no. 5 (November 2009): 719-725. Full Text Link to Item
  - Pitt, GS. "Channeling a New Focus for Heart Failure: Insights Into Ion Channels." JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 54, no. 2 (August 2009): 95-97. Link to Item
  - Thomsen, MB, Wang, C, Ozgen, N, Wang, H-G, Rosen, MR, and Pitt, GS. "Accessory subunit KChIP2 modulates the cardiac L-type calcium current." Circ Res 104, no. 12 (June 19, 2009): 1382-1389. Full Text Link to Item
  - Shah, SH, and Pitt, GS. "Genetics of cardiac repolarization." Nat Genet 41, no. 4 (April 2009): 388-389. Link to Item
  - Miloushev, VZ, Levine, JA, Arbing, MA, Hunt, JF, Pitt, GS, and Palmer, AG. "Solution structure of the NaV1.2 C-terminal EF-hand domain." J Biol Chem 284, no. 10 (March 6, 2009): 6446-6454. Full Text Link to Item
  - Pitt, GS. "Editorial: Channeling a new focus for heart failure: Insights into ion channels." Journal of Cardiovascular Pharmacology 54, no. 2 (2009): 95-97. Full Text
  - Pitt, GS. "Calcineurin finds a new partner in the L-type Ca²⁺ channel." Circulation Research 105, no. 1 (2009): 7-8. Full Text
  - Wang, C, Wang, H-G, Xie, H, and Pitt, GS. "Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini." J Neurosci 28, no. 8 (February 20, 2008): 1865-1870. Full Text Link to Item
  - Wang, H-G, George, MS, Kim, J, Wang, C, and Pitt, GS. "Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons." J Neurosci 27, no. 34 (August 22, 2007): 9086-9093. Full Text Link to Item
  - Pitt, B, and Pitt, GS. "Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death." Circulation 115, no. 23 (June 12, 2007): 2976-2982. (Review) Full Text Link to Item
  - Pitt, GS. "Calmodulin and CaMKII as molecular switches for cardiac ion channels." Cardiovasc Res 73, no. 4 (March 1, 2007): 641-647. (Review) Full Text Link to Item
  - Pitt, B, and Pitt, GS. "Response to Kloner and Cannom." Circulation 115, no. 23 (2007): 2989--. Full Text
  - Seu, L, and Pitt, GS. "Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases." J Gen Physiol 128, no. 5 (November 2006): 605-613. Full Text Link to Item
  - Pitt, GS, Dun, W, and Boyden, PA. "Remodeled cardiac calcium channels." J Mol Cell Cardiol 41, no. 3 (September 2006): 373-388. (Review) Full Text Link to Item
  - Pitt, GS, and Pitt, B. "Aldosterone, ion channels, and sudden death: another piece of the circle?." Am J Physiol Heart Circ Physiol 290, no. 6 (June 2006): H2176-H2177. Full Text Link to Item
  - George, MS, and Pitt, GS. "The real estate of cardiac signaling: location, location, location." Proc Natl Acad Sci U S A 103, no. 20 (May 16, 2006): 7535-7536. Full Text Link to Item
  - Ghosh, S, Nunziato, DA, and Pitt, GS. "KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin." Circ Res 98, no. 8 (April 28, 2006): 1048-1054. Full Text Link to Item
  - Hudmon, A, Schulman, H, Kim, J, Maltez, JM, Tsien, RW, and Pitt, GS. "CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation." J Cell Biol 171, no. 3 (November 7, 2005): 537-547. Full Text Link to Item
  - Maltez, JM, Nunziato, DA, Kim, J, and Pitt, GS. "Essential Ca(V)beta modulatory properties are AID-independent." Nat Struct Mol Biol 12, no. 4 (April 2005): 372-377. Full Text Link to Item
  - Kim, J, Ghosh, S, Liu, H, Tateyama, M, Kass, RS, and Pitt, GS. "Calmodulin mediates Ca2+ sensitivity of sodium channels." J Biol Chem 279, no. 43 (October 22, 2004): 45004-45012. Full Text Link to Item
  - McGee, AW, Nunziato, DA, Maltez, JM, Prehoda, KE, Pitt, GS, and Bredt, DS. "Calcium channel function regulated by the SH3-GK module in beta subunits." Neuron 42, no. 1 (April 8, 2004): 89-99. Link to Item
  - Kim, J, Ghosh, S, Nunziato, DA, and Pitt, GS. "Identification of the components controlling inactivation of voltage-gated Ca2+ channels." Neuron 41, no. 5 (March 4, 2004): 745-754. Link to Item
  - Pitt, GS, Zühlke, RD, Hudmon, A, Schulman, H, Reuter, H, and Tsien, RW. "Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels." J Biol Chem 276, no. 33 (August 17, 2001): 30794-30802. Full Text Link to Item
  - Pitt, GS, Zühlke, RD, Hudmon, A, Schulman, H, Reuter, H, and Tsien, RW. "Erratum: Molecular basis of calmodulin tethering and Ca ²⁺-dependent inactivation of L-type Ca²⁺ channels (Journal of Biological Chemistry (2001) 276 (30794-30802))." Journal of Biological Chemistry 276, no. 39 (2001): 36862--.
  - Zühlke, RD, Pitt, GS, Tsien, RW, and Reuter, H. "Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit." J Biol Chem 275, no. 28 (July 14, 2000): 21121-21129. Full Text Link to Item
  - Zühlke, RD, Pitt, GS, Deisseroth, K, Tsien, RW, and Reuter, H. "Calmodulin supports both inactivation and facilitation of L-type calcium channels." Nature 399, no. 6732 (May 13, 1999): 159-162. Full Text Link to Item
  - Mann, SKO, Brown, JM, Briscoe, C, Parent, C, Pitt, G, Devreotes, PN, and Firtel, RA. "Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in dictyostelium." Developmental Biology 183, no. 2 (1997): 208-221. Full Text
  - van Es, S, Virdy, KJ, Pitt, GS, Meima, M, Sands, TW, Devreotes, PN, Cotter, DA, and Schaap, P. "Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores." J Biol Chem 271, no. 39 (September 27, 1996): 23623-23625. Link to Item
  - Pitt, GS, Brandt, R, Lin, KC, Devreotes, PN, and Schaap, P. "Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA)." Genes Dev 7, no. 11 (November 1993): 2172-2180. Link to Item
  - Pupillo, M, Insall, R, Pitt, GS, and Devreotes, PN. "Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium." Mol Biol Cell 3, no. 11 (November 1992): 1229-1234. Link to Item
  - Okaichi, K, Cubitt, AB, Pitt, GS, and Firtel, RA. "Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C." Mol Biol Cell 3, no. 7 (July 1992): 735-747. Link to Item
  - Pitt, GS, Milona, N, Borleis, J, Lin, KC, Reed, RR, and Devreotes, PN. "Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development." Cell 69, no. 2 (April 17, 1992): 305-315. Link to Item
  - Johnson, RL, Gundersen, R, Hereld, D, Pitt, GS, Tugendreich, S, Saxe, CL, Kimmel, AR, and Devreotes, PN. "G-protein-linked signaling pathways mediate development in Dictyostelium." Cold Spring Harb Symp Quant Biol 57 (1992): 169-176. (Review) Link to Item
  - Pitt, GS, Gundersen, RE, and Devreotes, PN. "Mechanisms of excitation and adaptation in Dictyostelium." Semin Cell Biol 1, no. 2 (April 1990): 99-104. (Review) Link to Item
  - Pitt, GS, Gundersen, RE, Lilly, PJ, Pupillo, MB, Vaughan, RA, and Devreotes, PN. "G protein-linked signal transduction in aggregating Dictyostelium." Soc Gen Physiol Ser 45 (1990): 125-131. (Review) Link to Item
  - Pitt, GS, Gundersen, RE, Lilly, PJ, Pupillo, MB, Vaughan, RA, and Devreotes, PN. "G protein-linked signal transduction in aggregating Dictyostelium." Society of General Physiologists series 45 (1990): 125-131.
  - Pupillo, M, Kumagai, A, Pitt, GS, Firtel, RA, and Devreotes, PN. "Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium." Proc Natl Acad Sci U S A 86, no. 13 (July 1989): 4892-4896. Link to Item
  - Johnson, RL, Gundersen, R, Lilly, P, Pitt, GS, Pupillo, M, Sun, TJ, Vaughan, RA, and Devreotes, PN. "G-protein-linked signal transduction systems control development in Dictyostelium." Development 107 Suppl (1989): 75-80. Link to Item
  - Pitt, GS, and Devreotes, PN. "A simple BASIC program allows the rapid entry of DNA nucleotide sequences into personal computers." Biotechniques 6, no. 2 (February 1988): 122-123. Link to Item
  - Kumagai, A, Mann, SKO, Pupillo, M, Pitt, G, Devreotes, PN, and Firtel, RA. "A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium." Cold Spring Harbor Symposia on Quantitative Biology 53, no. 2 (1988): 675-685.
  - Pupillo, M, Klein, P, Vaughan, R, Pitt, G, Lilly, P, Sun, T, Devreotes, P, Kumagai, A, and Firtel, R. "cAMP receptor and G-protein interactions control development in Dictyostelium." Cold Spring Harbor Symposia on Quantitative Biology 53, no. 2 (1988): 657-665.
  - Khazaeli, MB, Beierwaltes, WH, Pitt, GS, Kabza, GA, Rogers, KJ, and LoBuglio, AF. "Development and characterization of a monoclonal antibody to human embryonal carcinoma." J Urol 137, no. 6 (June 1987): 1295-1299. Link to Item
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