Geoffrey Stuart Pitt | Scholars@Duke

Geoffrey Stuart Pitt
Adjunct Professor in the Department of Medicine

Our research focuses on how intracellular Ca²⁺ , the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca²⁺ influx through voltage-gated Ca²⁺ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca²⁺ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Current Appointments & Affiliations

Adjunct Professor in the Department of Medicine, Medicine, Cardiology, Medicine 2016
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011

Contact Information

Duke Box 103030, Durham, NC 27710
515 E. 79th Street, Pha, New York, NY 10075
geoffrey.pitt@duke.edu (919) 257-1589
Pitt lab website

Background
Education, Training, & Certifications
- Fellow in Cardiovascular Medicine, Medicine, Stanford University 1995 - 1999
- Medical Resident, Medicine, Stanford University 1993 - 1995
- M.D., Johns Hopkins University 1993
Duke Appointment History
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2007 - 2017
- Professor of Medicine, Medicine, Cardiology, Medicine 2014 - 2016
- Professor of Neurobiology, Neurobiology, Basic Science Departments 2014 - 2016
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2014 - 2016
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2014
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2008 - 2014
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2014
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2007 - 2008
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Fibroblast Growth Factor Homologous Factor Modulation and Effect on Cardiac Ion Channel Trafficking awarded by National Institutes of Health 2016 - 2018
- Identifying the mechanosensitive domains of the Piezo1 ion channel by application of localized force awarded by National Institutes of Health 2015 - 2017
- Bone-targeted calcium channel agonists for osteoporosis awarded by UH Harrington Discovery Institute 2015 - 2017
- Calcium regulation and dysregulation of cardiac ion channels awarded by National Institutes of Health 2008 - 2017
- Calmodulin regulation of Na+ channels in neurons and cardiomyocytes awarded by National Institutes of Health 2014 - 2016
- Structural studies of NaV1.5 and functional implications awarded by National Institutes of Health 2013 - 2016
- Investigation of calcium channel modulation in cardiomyocytes by novel methods awarded by Columbia University 2013 - 2016
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
Publications & Artistic Works
Selected Publications
- Books
  - Pitt, G. S. Ion Channels in Health and Disease, 2016. https://doi.org/10.1016/C2014-0-01711-X.
    Full Text
  - Pitt, G. S. Preface, 2016. https://doi.org/10.1016/B978-0-12-802002-9.05001-9.
    Full Text
- Academic Articles
  - Wang, Zizun, Sarah H. Vermij, Valentin Sottas, Anna Shestak, Daniela Ross-Kaschitza, Elena V. Zaklyazminskaya, Andy Hudmon, Geoffrey S. Pitt, Jean-Sébastien Rougier, and Hugues Abriel. “Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.” Channels (Austin) 14, no. 1 (December 2020): 268–86. https://doi.org/10.1080/19336950.2020.1805999.
    Full Text Link to Item
  - Abrams, Jeffrey, Daniel Roybal, Nourdine Chakouri, Alexander N. Katchman, Richard Weinberg, Lin Yang, Bi-Xing Chen, et al. “Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.” Jci Insight 5, no. 19 (October 2, 2020). https://doi.org/10.1172/jci.insight.141736.
    Full Text Link to Item
  - Gade, Aravind R., Steven O. Marx, and Geoffrey S. Pitt. “An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.” J Gen Physiol 152, no. 2 (February 3, 2020). https://doi.org/10.1085/jgp.201912434.
    Full Text Link to Item
  - Pitt, Geoffrey S., and Seok-Yong Lee. “Ca2+/CaM interaction with voltage-gated Na+ channels.” Proc Natl Acad Sci U S A, December 3, 2019. https://doi.org/10.1073/pnas.1909835116.
    Full Text Link to Item
  - Sinden, Daniel S., Corey D. Holman, Curtis J. Bare, Xiaolu Sun, Aravind R. Gade, David E. Cohen, and Geoffrey S. Pitt. “Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.” Faseb J 33, no. 10 (October 2019): 11579–94. https://doi.org/10.1096/fj.201901178R.
    Full Text Link to Item
  - Cao, Chike, Aaron B. Oswald, Brian A. Fabella, Yinshi Ren, Ramona Rodriguiz, George Trainor, Matthew B. Greenblatt, Matthew J. Hilton, and Geoffrey S. Pitt. “The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.” Bone 125 (August 2019): 160–68. https://doi.org/10.1016/j.bone.2019.05.024.
    Full Text Link to Item
  - Yang, Lin, Alexander Katchman, Jared Kushner, Alexander Kushnir, Sergey I. Zakharov, Bi-Xing Chen, Zunaira Shuja, et al. “Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.” The Journal of Clinical Investigation 129, no. 2 (February 2019): 647–58. https://doi.org/10.1172/jci123878.
    Full Text
  - Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, et al. “The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.” J Clin Invest 128, no. 11 (November 1, 2018): 4843–55. https://doi.org/10.1172/JCI95945.
    Full Text Link to Item
  - Pitt, Geoffrey S. “An update on the journey towards precision medicine in cardiology.” Eur Heart J 39, no. 40 (October 21, 2018): 3627–28. https://doi.org/10.1093/eurheartj/ehy637.
    Full Text Link to Item
  - Sanders, Stephan J., Arthur J. Campbell, Jeffrey R. Cottrell, Rikke S. Moller, Florence F. Wagner, Angie L. Auldridge, Raphael A. Bernier, et al. “Progress in Understanding and Treating SCN2A-Mediated Disorders.” Trends in Neurosciences 41, no. 7 (July 2018): 442–56. https://doi.org/10.1016/j.tins.2018.03.011.
    Full Text
  - Cao, Chike, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, et al. “Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.” Jci Insight 2, no. 22 (November 16, 2017). https://doi.org/10.1172/jci.insight.95512.
    Full Text Link to Item
  - Katchman, Alexander, Lin Yang, Sergey I. Zakharov, Jared Kushner, Jeffrey Abrams, Bi-Xing Chen, Guoxia Liu, Geoffrey S. Pitt, Henry M. Colecraft, and Steven O. Marx. “Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.” Proceedings of the National Academy of Sciences of the United States of America 114, no. 34 (August 7, 2017): 9194–99. https://doi.org/10.1073/pnas.1706054114.
    Full Text
  - Pablo, Juan Lorenzo, and Geoffrey S. Pitt. “Divide, multitask, and conquer: Coordination in channel regulation.” Channels (Austin) 11, no. 4 (July 4, 2017): 268–70. https://doi.org/10.1080/19336950.2017.1292814.
    Full Text Link to Item
  - Wei, Eric Q., Daniel S. Sinden, Lan Mao, Hailin Zhang, Chuan Wang, and Geoffrey S. Pitt. “Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.” Proc Natl Acad Sci U S A 114, no. 20 (May 16, 2017): E4010–19. https://doi.org/10.1073/pnas.1616393114.
    Full Text Link to Item
  - Wang, Xiangchong, He Tang, Eric Q. Wei, Zhihua Wang, Jing Yang, Rong Yang, Sheng Wang, et al. “Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.” J Mol Cell Cardiol 104 (March 2017): 63–74. https://doi.org/10.1016/j.yjmcc.2017.01.009.
    Full Text Link to Item
  - Yan, Haidun, Chaojian Wang, Steven O. Marx, and Geoffrey S. Pitt. “Calmodulin limits pathogenic Na+ channel persistent current.” J Gen Physiol 149, no. 2 (February 2017): 277–93. https://doi.org/10.1085/jgp.201611721.
    Full Text Link to Item
  - Pitt, Geoffrey S. “A view from the side-line.” Eur Heart J 37, no. 47 (December 14, 2016): 3488–89. https://doi.org/10.1093/eurheartj/ehw532.
    Full Text Link to Item
  - Yang, Jing, Zhihua Wang, Daniel S. Sinden, Xiangchong Wang, Bin Shan, Xiao Yu, Hailin Zhang, Geoffrey S. Pitt, and Chuan Wang. “FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.” Channels (Austin) 10, no. 5 (September 2, 2016): 410–20. https://doi.org/10.1080/19336950.2016.1190055.
    Full Text Link to Item
  - Black, Joshua B., Andrew F. Adler, Hong-Gang Wang, Anthony M. D’Ippolito, Hunter A. Hutchinson, Timothy E. Reddy, Geoffrey S. Pitt, Kam W. Leong, and Charles A. Gersbach. “Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.” Cell Stem Cell 19, no. 3 (September 1, 2016): 406–14. https://doi.org/10.1016/j.stem.2016.07.001.
    Full Text Link to Item
  - Pitt, Geoffrey S., and Seok-Yong Lee. “Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.” Protein Sci 25, no. 9 (September 2016): 1573–84. https://doi.org/10.1002/pro.2960.
    Full Text Link to Item
  - Sun, Albert Y., and Geoffrey S. Pitt. “Long QT Syndrome and Seizures.” Jacc Clin Electrophysiol 2, no. 3 (June 2016): 277–78. https://doi.org/10.1016/j.jacep.2015.12.015.
    Full Text Link to Item
  - Pablo, Juan Lorenzo, Chaojian Wang, Matthew M. Presby, and Geoffrey S. Pitt. “Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action.” Proc Natl Acad Sci U S A 113, no. 19 (May 10, 2016): E2665–74. https://doi.org/10.1073/pnas.1521194113.
    Full Text Link to Item
  - Matsui, Maiko, and Geoffrey S. Pitt. “Genetic variants and disease: correlate or cause?” Eur Heart J 37, no. 18 (May 7, 2016): 1476–78. https://doi.org/10.1093/eurheartj/ehv516.
    Full Text Link to Item
  - Wang, Hong-Gang, Wandi Zhu, Ronald J. Kanter, Jonathan R. Silva, Christina Honeywell, Robert M. Gow, and Geoffrey S. Pitt. “A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.” J Mol Cell Cardiol 92 (March 2016): 52–62. https://doi.org/10.1016/j.yjmcc.2016.01.014.
    Full Text Link to Item
  - Pablo, Juan L., and Geoffrey S. Pitt. “Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease.” Neuroscientist 22, no. 1 (February 2016): 19–25. https://doi.org/10.1177/1073858414562217.
    Full Text Link to Item
  - Choi, Jong-Il, Chaojian Wang, Matthew J. Thomas, and Geoffrey S. Pitt. “α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.” Plos One 11, no. 3 (2016): e0152355. https://doi.org/10.1371/journal.pone.0152355.
    Full Text Link to Item
  - Musa, Hassan, Crystal F. Kline, Amy C. Sturm, Nathaniel Murphy, Sara Adelman, Chaojian Wang, Haidun Yan, et al. “SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.” Proceedings of the National Academy of Sciences of the United States of America 112, no. 40 (October 2015): 12528–33. https://doi.org/10.1073/pnas.1516430112.
    Full Text
  - Pitt, Geoffrey S. “Cardiovascular precision medicine: hope or hype?” Eur Heart J 36, no. 29 (August 1, 2015): 1842–43. https://doi.org/10.1093/eurheartj/ehv226.
    Full Text Link to Item
  - Chen-Izu, Ye, Robin M. Shaw, Geoffrey S. Pitt, Vladimir Yarov-Yarovoy, Jon T. Sack, Hugues Abriel, Richard W. Aldrich, et al. “Na+ channel function, regulation, structure, trafficking and sequestration.” J Physiol 593, no. 6 (March 15, 2015): 1347–60. https://doi.org/10.1113/jphysiol.2014.281428.
    Full Text Link to Item
  - Andersen, Nicholas D., Kapil V. Ramachandran, Michelle M. Bao, Margaret L. Kirby, Geoffrey S. Pitt, and Mary R. Hutson. “Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow.” J Mol Cell Cardiol 80 (March 2015): 1–9. https://doi.org/10.1016/j.yjmcc.2014.12.016.
    Full Text Link to Item
  - Yang, Lin, Alexander Katchman, Richard L. Weinberg, Jeffrey Abrams, Tahmina Samad, Elaine Wan, Geoffrey S. Pitt, and Steven O. Marx. “The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.” J Biol Chem 290, no. 4 (January 23, 2015): 2166–74. https://doi.org/10.1074/jbc.M114.602508.
    Full Text Link to Item
  - Betzenhauser, Matthew J., Geoffrey S. Pitt, and Charles Antzelevitch. “Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.” Curr Mol Pharmacol 8, no. 2 (2015): 133–42. https://doi.org/10.2174/1874467208666150518114857.
    Full Text Link to Item
  - Yan, Haidun, Juan L. Pablo, Chaojian Wang, and Geoffrey S. Pitt. “FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons.” Elife 3 (September 30, 2014): e04193. https://doi.org/10.7554/eLife.04193.
    Full Text Link to Item
  - Wang, Chaojian, Ben C. Chung, Haidun Yan, Hong-Gang Wang, Seok-Yong Lee, and Geoffrey S. Pitt. “Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.” Nat Commun 5 (September 18, 2014): 4896. https://doi.org/10.1038/ncomms5896.
    Full Text Link to Item
  - Abbott, Geoffrey W., and Geoffrey S. Pitt. “Ion channels under the sun.” Faseb J 28, no. 5 (May 2014): 1957–62. https://doi.org/10.1096/fj.14-0501ufm.
    Full Text Link to Item
  - Hennessey, Jessica A., Nicole J. Boczek, Yong-Hui Jiang, Joelle D. Miller, William Patrick, Ryan Pfeiffer, Brittan S. Sutphin, et al. “A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis.” Plos One 9, no. 9 (2014): e106982. https://doi.org/10.1371/journal.pone.0106982.
    Full Text Link to Item
  - Hennessey, Jessica A., Cherisse A. Marcou, Chuan Wang, Eric Q. Wei, Chaojian Wang, David J. Tester, Margherita Torchio, et al. “FGF12 is a candidate Brugada syndrome locus.” Heart Rhythm 10, no. 12 (December 2013): 1886–94. https://doi.org/10.1016/j.hrthm.2013.09.064.
    Full Text Link to Item
  - Hennessey, J. A., Y. Jiang, J. D. Miller, H. A. Stadt, W. Patrick, R. Pfeiffer, C. Antzelevitch, R. Kanter, and G. S. Pitt. “A CACNA1C Mutation that Causes a Subset of Timothy Syndrome Phenotypes Correlates.” Heart Rhythm 10, no. 11 (November 2013): 1745. https://doi.org/10.1016/j.hrthm.2013.09.026.
    Full Text Link to Item
  - Hennessey, Jessica A., Eric Q. Wei, and Geoffrey S. Pitt. “Fibroblast growth factor homologous factors modulate cardiac calcium channels.” Circ Res 113, no. 4 (August 2, 2013): 381–88. https://doi.org/10.1161/CIRCRESAHA.113.301215.
    Full Text Link to Item
  - Yan, Haidun, Juan L. Pablo, and Geoffrey S. Pitt. “FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.” Cell Rep 4, no. 1 (July 11, 2013): 66–75. https://doi.org/10.1016/j.celrep.2013.06.012.
    Full Text Link to Item
  - Wang, Hong-Gang, Xiao Ping He, Qiang Li, Roger D. Madison, Scott D. Moore, James O. McNamara, and Geoffrey S. Pitt. “The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.” J Biol Chem 288, no. 19 (May 10, 2013): 13258–68. https://doi.org/10.1074/jbc.M112.434548.
    Full Text Link to Item
  - Ramachandran, Kapil V., Jessica A. Hennessey, Adam S. Barnett, Xinhe Yin, Harriett A. Stadt, Erika Foster, Raj A. Shah, et al. “Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.” J Clin Invest 123, no. 4 (April 2013): 1638–46. https://doi.org/10.1172/JCI66903.
    Full Text Link to Item
  - Chen, Benny J., Yiqun Jiao, Ping Zhang, Albert Y. Sun, Geoffrey S. Pitt, Divino Deoliveira, Nicholas Drago, Tong Ye, Chen Liu, and Nelson J. Chao. “Long-term in vivo imaging of multiple organs at the single cell level.” Plos One 8, no. 1 (2013): e52087. https://doi.org/10.1371/journal.pone.0052087.
    Full Text Link to Item
  - Daubert, James P., and Geoffrey S. Pitt. “Can polymorphisms predict response to antiarrhythmic drugs in atrial fibrillation?” J Am Coll Cardiol 60, no. 6 (August 7, 2012): 546–47. https://doi.org/10.1016/j.jacc.2012.02.060.
    Full Text Link to Item
  - Stephens, Samuel B., Jonathan C. Schisler, Hans E. Hohmeier, Jie An, Albert Y. Sun, Geoffrey S. Pitt, and Christopher B. Newgard. “A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.” Cell Metab 16, no. 1 (July 3, 2012): 33–43. https://doi.org/10.1016/j.cmet.2012.05.011.
    Full Text Link to Item
  - Wang, Chaojian, Ben C. Chung, Haidun Yan, Seok-Yong Lee, and Geoffrey S. Pitt. “Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.” Structure 20, no. 7 (July 3, 2012): 1167–76. https://doi.org/10.1016/j.str.2012.05.001.
    Full Text Link to Item
  - Zhong, Lixian, Andrew Bellemer, Haidun Yan, Honjo Ken, Robertson Jessica, Richard Y. Hwang, Geoffrey S. Pitt, and W Daniel Tracey. “Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel.” Cell Rep 1, no. 1 (January 26, 2012): 43–55. https://doi.org/10.1016/j.celrep.2011.11.002.
    Full Text Link to Item
  - Amenta, Jessica, and Geoffrey S. Pitt. “Novel Roles of Fibroblast Growth Factor Homologous Factors in Heart.” Biophysical Journal 102, no. 3 (January 2012): 34a-34a. https://doi.org/10.1016/j.bpj.2011.11.215.
    Full Text
  - Lodder, Elisabeth M., Brendon P. Scicluna, Annalisa Milano, Albert Y. Sun, Hao Tang, Carol Ann Remme, Perry D. Moerland, et al. “Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.” Plos Genet 8, no. 12 (2012): e1003113. https://doi.org/10.1371/journal.pgen.1003113.
    Full Text Link to Item
  - Wei, Eric Q., Adam S. Barnett, Geoffrey S. Pitt, and Jessica A. Hennessey. “Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.” Trends Cardiovasc Med 21, no. 7 (October 2011): 199–203. https://doi.org/10.1016/j.tcm.2012.05.010.
    Full Text Link to Item
  - Wang, Chuan, Jessica A. Hennessey, Robert D. Kirkton, Chaojian Wang, Victoria Graham, Ram S. Puranam, Paul B. Rosenberg, Nenad Bursac, and Geoffrey S. Pitt. “Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.” Circ Res 109, no. 7 (September 16, 2011): 775–82. https://doi.org/10.1161/CIRCRESAHA.111.247957.
    Full Text Link to Item
  - Wang, Chaojian, Chuan Wang, Ethan G. Hoch, and Geoffrey S. Pitt. “Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels.” J Biol Chem 286, no. 27 (July 8, 2011): 24253–63. https://doi.org/10.1074/jbc.M111.245803.
    Full Text Link to Item
  - Sun, Albert Y., Jason I. Koontz, Svati H. Shah, Jonathan P. Piccini, Kent R. Nilsson, Damian Craig, Carol Haynes, Simon G. Gregory, Patrick M. Hranitzky, and Geoffrey S. Pitt. “The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.” Circ Cardiovasc Genet 4, no. 2 (April 2011): 163–68. https://doi.org/10.1161/CIRCGENETICS.110.958652.
    Full Text Link to Item
  - Sun, Albert Y., and Geoffrey S. Pitt. “Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation.” Heart Rhythm 8, no. 4 (April 2011): 631–33. https://doi.org/10.1016/j.hrthm.2010.10.001.
    Full Text Link to Item
  - Wang, Hong-Gang, Chuan Wang, and Geoffrey S. Pitt. “Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.” Plos One 6, no. 9 (2011): e25741. https://doi.org/10.1371/journal.pone.0025741.
    Full Text Link to Item
  - Amenta, Jessica J., and Geoffrey S. Pitt. “The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method".” Am J Physiol Cell Physiol 298, no. 6 (June 2010): C1305–7. https://doi.org/10.1152/ajpcell.00110.2010.
    Full Text Link to Item
  - Koontz, Jason I., Daniel Haithcock, Valerie Cumbea, Anthony Waldron, Kristie Stricker, Amy Hughes, Kent Nilsson, et al. “Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository.” Am Heart J 158, no. 5 (November 2009): 719–25. https://doi.org/10.1016/j.ahj.2009.08.011.
    Full Text Link to Item
  - Pitt, Geoffrey S. “Channeling a new focus for heart failure: insights into ion channels.” J Cardiovasc Pharmacol 54, no. 2 (August 2009): 95–97. https://doi.org/10.1097/FJC.0b013e3181b2b6bd.
    Full Text Link to Item
  - Pitt, Geoffrey S. “Calcineurin finds a new partner in the L-type Ca2+ channel.” Circ Res 105, no. 1 (July 2, 2009): 7–8. https://doi.org/10.1161/CIRCRESAHA.109.201236.
    Full Text Link to Item
  - Thomsen, Morten B., Chaojian Wang, Nazira Ozgen, Hong-Gang Wang, Michael R. Rosen, and Geoffrey S. Pitt. “Accessory subunit KChIP2 modulates the cardiac L-type calcium current.” Circ Res 104, no. 12 (June 19, 2009): 1382–89. https://doi.org/10.1161/CIRCRESAHA.109.196972.
    Full Text Link to Item
  - Shah, Svati H., and Geoffrey S. Pitt. “Genetics of cardiac repolarization.” Nat Genet 41, no. 4 (April 2009): 388–89. https://doi.org/10.1038/ng0409-388.
    Full Text Link to Item
  - Miloushev, Vesselin Z., Joshua A. Levine, Mark A. Arbing, John F. Hunt, Geoffrey S. Pitt, and Arthur G. Palmer. “Solution structure of the NaV1.2 C-terminal EF-hand domain.” J Biol Chem 284, no. 10 (March 6, 2009): 6446–54. https://doi.org/10.1074/jbc.M807401200.
    Full Text Link to Item
  - Wang, Chaojian, Hong-Gang Wang, Hui Xie, and Geoffrey S. Pitt. “Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini.” J Neurosci 28, no. 8 (February 20, 2008): 1865–70. https://doi.org/10.1523/JNEUROSCI.5417-07.2008.
    Full Text Link to Item
  - Wang, Hong-Gang, Meena S. George, James Kim, Chaojian Wang, and Geoffrey S. Pitt. “Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons.” J Neurosci 27, no. 34 (August 22, 2007): 9086–93. https://doi.org/10.1523/JNEUROSCI.1720-07.2007.
    Full Text Link to Item
  - Pitt, Bertram, and Geoffrey S. Pitt. “Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death.” Circulation 115, no. 23 (June 12, 2007): 2976–82. https://doi.org/10.1161/CIRCULATIONAHA.106.670109.
    Full Text Link to Item
  - Pitt, B., and G. S. Pitt. “Response to Kloner and Cannom.” Circulation 115, no. 23 (June 1, 2007): 2989. https://doi.org/10.1161/CIRCULATIONAHA.106.684522.
    Full Text
  - Pitt, Geoffrey S. “Calmodulin and CaMKII as molecular switches for cardiac ion channels.” Cardiovasc Res 73, no. 4 (March 1, 2007): 641–47. https://doi.org/10.1016/j.cardiores.2006.10.019.
    Full Text Link to Item
  - Seu, Lillian, and Geoffrey S. Pitt. “Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.” J Gen Physiol 128, no. 5 (November 2006): 605–13. https://doi.org/10.1085/jgp.200609631.
    Full Text Link to Item
  - Pitt, Geoffrey S., Wen Dun, and Penelope A. Boyden. “Remodeled cardiac calcium channels.” J Mol Cell Cardiol 41, no. 3 (September 2006): 373–88. https://doi.org/10.1016/j.yjmcc.2006.06.071.
    Full Text Link to Item
  - Pitt, Geoffrey S., and Bertram Pitt. “Aldosterone, ion channels, and sudden death: another piece of the circle?” Am J Physiol Heart Circ Physiol 290, no. 6 (June 2006): H2176–77. https://doi.org/10.1152/ajpheart.00186.2006.
    Full Text Link to Item
  - George, Meena S., and Geoffrey S. Pitt. “The real estate of cardiac signaling: location, location, location.” Proc Natl Acad Sci U S A 103, no. 20 (May 16, 2006): 7535–36. https://doi.org/10.1073/pnas.0602389103.
    Full Text Link to Item
  - Ghosh, Smita, Deborah A. Nunziato, and Geoffrey S. Pitt. “KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin.” Circ Res 98, no. 8 (April 28, 2006): 1048–54. https://doi.org/10.1161/01.RES.0000218863.44140.f2.
    Full Text Link to Item
  - Hudmon, Andy, Howard Schulman, James Kim, Janet M. Maltez, Richard W. Tsien, and Geoffrey S. Pitt. “CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.” The Journal of Cell Biology 171, no. 3 (November 2005): 537–47. https://doi.org/10.1083/jcb.200505155.
    Full Text
  - Maltez, Janet M., Deborah A. Nunziato, James Kim, and Geoffrey S. Pitt. “Essential Ca(V)beta modulatory properties are AID-independent.” Nat Struct Mol Biol 12, no. 4 (April 2005): 372–77. https://doi.org/10.1038/nsmb909.
    Full Text Link to Item
  - Kim, James, Smita Ghosh, Huajun Liu, Michihiro Tateyama, Robert S. Kass, and Geoffrey S. Pitt. “Calmodulin mediates Ca2+ sensitivity of sodium channels.” J Biol Chem 279, no. 43 (October 22, 2004): 45004–12. https://doi.org/10.1074/jbc.M407286200.
    Full Text Link to Item
  - McGee, Aaron W., Deborah A. Nunziato, Janet M. Maltez, Kenneth E. Prehoda, Geoffrey S. Pitt, and David S. Bredt. “Calcium channel function regulated by the SH3-GK module in beta subunits.” Neuron 42, no. 1 (April 8, 2004): 89–99. https://doi.org/10.1016/s0896-6273(04)00149-7.
    Full Text Link to Item
  - Kim, James, Smita Ghosh, Deborah A. Nunziato, and Geoffrey S. Pitt. “Identification of the components controlling inactivation of voltage-gated Ca2+ channels.” Neuron 41, no. 5 (March 4, 2004): 745–54. https://doi.org/10.1016/s0896-6273(04)00081-9.
    Full Text Link to Item
  - Pitt, G. S., R. D. Zühlke, A. Hudmon, H. Schulman, H. Reuter, and R. W. Tsien. “Erratum: Molecular basis of calmodulin tethering and Ca ²⁺-dependent inactivation of L-type Ca²⁺ channels (Journal of Biological Chemistry (2001) 276 (30794-30802)).” Journal of Biological Chemistry 276, no. 39 (September 28, 2001): 36862.
  - Pitt, G. S., R. D. Zühlke, A. Hudmon, H. Schulman, H. Reuter, and R. W. Tsien. “Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels.” J Biol Chem 276, no. 33 (August 17, 2001): 30794–802. https://doi.org/10.1074/jbc.M104959200.
    Full Text Link to Item
  - Zühlke, R. D., G. S. Pitt, R. W. Tsien, and H. Reuter. “Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit.” J Biol Chem 275, no. 28 (July 14, 2000): 21121–29. https://doi.org/10.1074/jbc.M002986200.
    Full Text Link to Item
  - Zühlke, R. D., G. S. Pitt, K. Deisseroth, R. W. Tsien, and H. Reuter. “Calmodulin supports both inactivation and facilitation of L-type calcium channels.” Nature 399, no. 6732 (May 13, 1999): 159–62. https://doi.org/10.1038/20200.
    Full Text Link to Item
  - Mann, S. K., J. M. Brown, C. Briscoe, C. Parent, G. Pitt, P. N. Devreotes, and R. A. Firtel. “Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.” Dev Biol 183, no. 2 (March 15, 1997): 208–21. https://doi.org/10.1006/dbio.1996.8499.
    Full Text Link to Item
  - Es, S. van, K. J. Virdy, G. S. Pitt, M. Meima, T. W. Sands, P. N. Devreotes, D. A. Cotter, and P. Schaap. “Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores.” J Biol Chem 271, no. 39 (September 27, 1996): 23623–25. https://doi.org/10.1074/jbc.271.39.23623.
    Full Text Link to Item
  - Pitt, G. S., R. Brandt, K. C. Lin, P. N. Devreotes, and P. Schaap. “Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).” Genes Dev 7, no. 11 (November 1993): 2172–80. https://doi.org/10.1101/gad.7.11.2172.
    Full Text Link to Item
  - Pupillo, M., R. Insall, G. S. Pitt, and P. N. Devreotes. “Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.” Mol Biol Cell 3, no. 11 (November 1992): 1229–34. https://doi.org/10.1091/mbc.3.11.1229.
    Full Text Link to Item
  - Okaichi, K., A. B. Cubitt, G. S. Pitt, and R. A. Firtel. “Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.” Mol Biol Cell 3, no. 7 (July 1992): 735–47. https://doi.org/10.1091/mbc.3.7.735.
    Full Text Link to Item
  - Pitt, G. S., N. Milona, J. Borleis, K. C. Lin, R. R. Reed, and P. N. Devreotes. “Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development.” Cell 69, no. 2 (April 17, 1992): 305–15. https://doi.org/10.1016/0092-8674(92)90411-5.
    Full Text Link to Item
  - Johnson, R. L., R. Gundersen, D. Hereld, G. S. Pitt, S. Tugendreich, C. L. Saxe, A. R. Kimmel, and P. N. Devreotes. “G-protein-linked signaling pathways mediate development in Dictyostelium.” Cold Spring Harb Symp Quant Biol 57 (1992): 169–76. https://doi.org/10.1101/sqb.1992.057.01.022.
    Full Text Link to Item
  - Pitt, G. S., R. E. Gundersen, and P. N. Devreotes. “Mechanisms of excitation and adaptation in Dictyostelium.” Semin Cell Biol 1, no. 2 (April 1990): 99–104.
    Link to Item
  - Pitt, G. S., R. E. Gundersen, P. J. Lilly, M. B. Pupillo, R. A. Vaughan, and P. N. Devreotes. “G protein-linked signal transduction in aggregating Dictyostelium.” Soc Gen Physiol Ser 45 (1990): 125–31.
    Link to Item
  - Pitt, G. S., R. E. Gundersen, P. J. Lilly, M. B. Pupillo, R. A. Vaughan, and P. N. Devreotes. “G protein-linked signal transduction in aggregating Dictyostelium.” Society of General Physiologists Series 45 (January 1, 1990): 125–31.
  - Pupillo, M., A. Kumagai, G. S. Pitt, R. A. Firtel, and P. N. Devreotes. “Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.” Proc Natl Acad Sci U S A 86, no. 13 (July 1989): 4892–96. https://doi.org/10.1073/pnas.86.13.4892.
    Full Text Link to Item
  - Johnson, R. L., R. Gundersen, P. Lilly, G. S. Pitt, M. Pupillo, T. J. Sun, R. A. Vaughan, and P. N. Devreotes. “G-protein-linked signal transduction systems control development in Dictyostelium.” Development 107 Suppl (1989): 75–80.
    Link to Item
  - Pitt, G. S., and P. N. Devreotes. “A simple BASIC program allows the rapid entry of DNA nucleotide sequences into personal computers.” Biotechniques 6, no. 2 (February 1988): 122–23.
    Link to Item
  - Kumagai, A., S. K. O. Mann, M. Pupillo, G. Pitt, P. N. Devreotes, and R. A. Firtel. “A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium.” Cold Spring Harbor Symposia on Quantitative Biology 53, no. 2 (1988): 675–85.
  - Pupillo, M., P. Klein, R. Vaughan, G. Pitt, P. Lilly, T. Sun, P. Devreotes, A. Kumagai, and R. Firtel. “cAMP receptor and G-protein interactions control development in Dictyostelium.” Cold Spring Harbor Symposia on Quantitative Biology 53, no. 2 (1988): 657–65.
  - Khazaeli, M. B., W. H. Beierwaltes, G. S. Pitt, G. A. Kabza, K. J. Rogers, and A. F. LoBuglio. “Development and characterization of a monoclonal antibody to human embryonal carcinoma.” J Urol 137, no. 6 (June 1987): 1295–99. https://doi.org/10.1016/s0022-5347(17)44486-7.
    Full Text Link to Item
- Book Sections
  - Pitt, G. S. “Fibroblast Growth Factor Homologous Factors Modulate Cardiac Sodium and Calcium Channels.” In Cardiac Electrophysiology: From Cell to Bedside: Seventh Edition, 177–79, 2018. https://doi.org/10.1016/B978-0-323-44733-1.00019-5.
    Full Text
  - Pitt, G. S., and S. O. Marx. “Calmodulin and CaMKII as Ca²⁺ Switches for Cardiac Ion Channels.” In Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition, 189–95, 2013. https://doi.org/10.1016/B978-1-4557-2856-5.00019-4.
    Full Text
- Conference Papers
  - Zhang, Hengtao, Albert Y. Sun, Jong J. Kim, Victoria Graham, Elizabeth A. Finch, Igor Nepliouev, Guiling Zhao, et al. “STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.” In Proceedings of the National Academy of Sciences of the United States of America, 112:E5618–27, 2015. https://doi.org/10.1073/pnas.1503847112.
    Full Text
  - Hennessey, Jessica A., Cherisse A. Marcou, Chuan Wang, Eric Q. Wei, Chaojian Wang, Lia Crotti, Peter Schwartz, Michael J. Ackerman, and Geoffrey S. Pitt. “FGF12 is a Novel Brugada Syndrome Locus.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
    Link to Item
  - Kumagai, A., S. K. Mann, M. Pupillo, G. Pitt, P. N. Devreotes, and R. A. Firtel. “A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium.” In Cold Spring Harb Symp Quant Biol, 53 Pt 2:675–85, 1988. https://doi.org/10.1101/sqb.1988.053.01.077.
    Full Text Link to Item
  - Pupillo, M., P. Klein, R. Vaughan, G. Pitt, P. Lilly, T. Sun, P. Devreotes, A. Kumagai, and R. Firtel. “cAMP receptor and G-protein interactions control development in Dictyostelium.” In Cold Spring Harb Symp Quant Biol, 53 Pt 2:657–65, 1988. https://doi.org/10.1101/sqb.1988.053.01.075.
    Full Text Link to Item
Teaching & Mentoring
Advising & Mentoring
Available to mentor:
- Affiliate

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Books

Academic Articles

Book Sections

Conference Papers

Advising & Mentoring

Available to mentor: