Overview
Current Appointments & Affiliations
Adjunct Professor in the Department of Medicine
·
2016 - Present
Medicine, Cardiology,
Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
·
2011 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Recent Publications
Ceramide-induced FGF13 impairs systemic metabolic health.
Journal Article Cell Metab · May 6, 2025 Ceramide accumulation impairs adipocytes' ability to efficiently store and utilize nutrients, leading to energy and glucose homeostasis deterioration. Using a comparative transcriptomic screen, we identified the non-canonical, non-secreted fibroblast growt ... Full text Link to item CiteSudden unexpected death in epilepsy: respiratory vs. cardiac contributions.
Journal Article Cardiovasc Res · April 8, 2025 Sudden unexpected death in epilepsy (SUDEP) poses a significant risk to life expectancy for individuals with epilepsy. Mechanistic insight, while incomplete, has advanced through clinical observational studies and animal models. Yet we lack preventative th ... Full text Link to item CiteInterneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism.
Journal Article Elife · January 8, 2025 Developmental and epileptic encephalopathies (DEEs), a class of devastating neurological disorders characterized by recurrent seizures and exacerbated by disruptions to excitatory/inhibitory balance in the brain, are commonly caused by mutations in ion cha ... Full text Link to item CiteRecent Grants
Basic predoctoral training in neuroscience
Inst. Training Prgm or CMETraining Faculty · Awarded by National Institutes of Health · 1992 - 2018Fibroblast Growth Factor Homologous Factor Modulation and Effect on Cardiac Ion Channel Trafficking
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018Identifying the mechanosensitive domains of the Piezo1 ion channel by application of localized force
FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2015 - 2017View All Grants
Education, Training & Certifications
Johns Hopkins University ·
1993
M.D.