Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Endocrinology, Medicine, Duke University 2000 - 2003
  • Medical Resident, Medicine, Duke University 1997 - 2000
  • M.D., Duke University 1997
  • Ph.D., University of North Carolina - Chapel Hill 1995
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2007 - 2011
  • Medical Instructor in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2003 - 2007
• Research
• 

  Selected Grants

  • Parathyroid hormone and osteoblast mitogenesis awarded by National Institutes of Health 2002 - 2006
  • Tyrosine kinases in G protein signaling awarded by National Institutes of Health 1998 - 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Gesty-Palmer, Diane, and Louis M. Luttrell. “'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?” Br J Pharmacol 164, no. 1 (September 2011): 59–67. https://doi.org/10.1111/j.1476-5381.2011.01450.x.
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    • Lakey, Wanda C., Susan Spratt, Emily N. Vinson, Diane Gesty-Palmer, Thomas Weber, and Scott Palmer. “Osteoporosis in lung transplant candidates compared to matched healthy controls.” Clin Transplant 25, no. 3 (2011): 426–35. https://doi.org/10.1111/j.1399-0012.2010.01263.x.
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    • DuSell, Carolyn D., Erik R. Nelson, Xiaojuan Wang, Jennifer Abdo, Ulrike I. Mödder, Michihisa Umetani, Diane Gesty-Palmer, Norman B. Javitt, Sundeep Khosla, and Donald P. McDonnell. “The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.” Endocrinology 151, no. 8 (August 2010): 3675–85. https://doi.org/10.1210/en.2010-0080.
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    • Chen, Benny J., Divino Deoliveira, Ivan Spasojevic, Gregory D. Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, et al. “Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.” Plos One 5, no. 6 (June 16, 2010): e11056. https://doi.org/10.1371/journal.pone.0011056.
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    • Luttrell, Louis M., and Diane Gesty-Palmer. “Beyond desensitization: physiological relevance of arrestin-dependent signaling.” Pharmacol Rev 62, no. 2 (June 2010): 305–30. https://doi.org/10.1124/pr.109.002436.
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    • Gesty-Palmer, Diane, Pat Flannery, Ling Yuan, Leonor Corsino, Robert Spurney, Robert J. Lefkowitz, and Louis M. Luttrell. “A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.” Sci Transl Med 1, no. 1 (October 7, 2009): 1ra1. https://doi.org/10.1126/scitranslmed.3000071.
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    • Wang, Liming, Diane Gesty-Palmer, Timothy A. Fields, and Robert F. Spurney. “Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).” Mol Endocrinol 23, no. 9 (September 2009): 1455–65. https://doi.org/10.1210/me.2009-0084.
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    • Shukla, Arun K., Jonathan D. Violin, Erin J. Whalen, Diane Gesty-Palmer, Sudha K. Shenoy, and Robert J. Lefkowitz. “Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.” Proc Natl Acad Sci U S A 105, no. 29 (July 22, 2008): 9988–93. https://doi.org/10.1073/pnas.0804246105.
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    • Gesty-Palmer, Diane, and Louis M. Luttrell. “Heptahelical terpsichory. Who calls the tune?” J Recept Signal Transduct Res 28, no. 1–2 (2008): 39–58. https://doi.org/10.1080/10799890801941921.
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    • Gesty-Palmer, Diane, Minyong Chen, Eric Reiter, Seungkirl Ahn, Christopher D. Nelson, Shuntai Wang, Allen E. Eckhardt, et al. “Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.” J Biol Chem 281, no. 16 (April 21, 2006): 10856–64. https://doi.org/10.1074/jbc.M513380200.
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    • Gesty-Palmer, Diane, Hesham El Shewy, Trudy A. Kohout, and Louis M. Luttrell. “beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.” J Biol Chem 280, no. 37 (September 16, 2005): 32157–67. https://doi.org/10.1074/jbc.M507460200.
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    • Pi, Min, Robert H. Oakley, Diane Gesty-Palmer, Rachael D. Cruickshank, Robert F. Spurney, Louis M. Luttrell, and L Darryl Quarles. “Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.” Mol Endocrinol 19, no. 4 (April 2005): 1078–87. https://doi.org/10.1210/me.2004-0450.
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    • Ahmed, Intekhab, Diane Gesty-Palmer, Marc K. Drezner, and Louis M. Luttrell. “Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.” Mol Endocrinol 17, no. 8 (August 2003): 1607–21. https://doi.org/10.1210/me.2002-0040.
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    • Tohgo, Akira, Eric W. Choy, Diane Gesty-Palmer, Kristen L. Pierce, Stephane Laporte, Robert H. Oakley, Marc G. Caron, Robert J. Lefkowitz, and Louis M. Luttrell. “The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.” J Biol Chem 278, no. 8 (February 21, 2003): 6258–67. https://doi.org/10.1074/jbc.M212231200.
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