Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of North Carolina at Chapel Hill 1994
• 

  Duke Appointment History

  • Assistant Professor of Radiology, Radiology, Breast Imaging, Radiology 2012 - 2013
  • Assistant Professor of Radiology, Radiology, Breast Imaging, Radiology 2005 - 2012
  • Associate in the Department of Radiology, Radiology, Breast Imaging, Radiology 2003 - 2005
  • Clinical Associate in the Department of Radiology, Radiology, Breast Imaging, Radiology 2002 - 2003
• Research
• 

  Selected Grants

  • Can contrast dynamics in breast MRI predict genomic intra-tumor heterogeneity awarded by Bracco Diagnostics, Inc. 2016 - 2020
  • Machine learning and collaborative filtering tools for personalized education in digital breast tomosynthesis awarded by National Institutes of Health 2016 - 2020
  • Diagnostic Utility of MRI in Female Patients with Nipple Discharge: A Prospective Trial awarded by Bracco Diagnostics, Inc. 2016 - 2018
  • Commericialization of a computational imaging-based biomarker for prognostication in breast cancer awarded by North Carolina Biotechnology Center 2016 - 2017
  • Simultaneous Emission and Transmission Mammotomography awarded by National Institutes of Health 2002 - 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Saha, A, Harowicz, MR, Grimm, LJ, Kim, CE, Ghate, SV, Walsh, R, and Mazurowski, MA. "Association of high proliferation marker Ki-67 expression with DCEMR imaging features of breast: A large scale evaluation." January 1, 2018.  Full Text
    • Zhang, J, Ghate, SV, Grimm, LJ, Saha, A, Cain, EH, Zhu, Z, and Mazurowski, MA. "Convolutional encoder-decoder for breast mass segmentation in digital breast tomosynthesis." January 1, 2018.  Full Text
    • Wang, M, Zhang, J, Grimm, LJ, Ghate, SV, Walsh, R, Johnson, KS, Lo, JY, and Mazurowski, MA. "Identification of error making patterns in lesion detection on digital breast tomosynthesis using computer-extracted image features." January 1, 2016.  Full Text
    • Pien, IJ, Bahl, M, Buretta, KJ, Greenup, RA, Ghate, SV, and Hollenbeck, ST. "Vascular Patterns on Preoperative Breast MRI Predict Ischemia and Necrosis after Nipple-Sparing Mastectomy." October 2015.  Full Text
    • Kiarashi, N, Nolte, LW, Lo, JY, Segars, WP, Ghate, SV, and Samei, E. "The impact of breast structure on lesion detection in breast tomosynthesis." January 1, 2015.  Full Text
    • Mazurowski, MA, Zhang, J, Lo, JY, Kuzmiak, CM, Ghate, SV, and Yoon, S. "Modeling resident error-making patterns in detection of mammographic masses using computer-extracted image features: Preliminary experiments." January 1, 2014.  Full Text
    • Ikejimba, L, Kiarashi, N, Lin, Y, Chen, B, Ghate, SV, Zerhouni, M, Samei, E, and Lo, JY. "Task-based strategy for optimized contrast enhanced breast imaging: Analysis of six imaging techniques for mammography and tomosynthesis." 2012.  Full Text
    • Kiarashi, N, Lin, Y, Segars, WP, Ghate, SV, Ikejimba, L, Chen, B, Lo, JY, Iii, JTD, Nolte, LW, and Samei, E. "Development of a dynamic 4D anthropomorphic breast phantom for contrast-based breast imaging." 2012.  Full Text
    • Lin, Y, Ghate, S, Lo, J, and Samei, E. "3D biopsy for tomosynthesis: Simulation of prior information based reconstruction for dose and artifact reduction." 2012.  Full Text
    • Ghate, SV, and Rosen, EL. "MRI-guided breast biopsies using a novel hand-held portable breast biopsy system." 2005.  Link to Item
    • Soo, MS, Baker, JA, Ghate, SV, Walsh, R, Warwick, B, and Nightingale, K. "Streaming detection for evaluation of indeterminate sono-graphic breast masses - A pilot study." 2005.  Link to Item

  • Journal Articles

    • Saha, A, Harowicz, MR, Grimm, LJ, Kim, CE, Ghate, SV, Walsh, R, and Mazurowski, MA. "A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features." British Journal of Cancer (July 23, 2018).  Full Text
    • Grimm, LJ, Saha, A, Ghate, SV, Kim, C, Soo, MS, Yoon, SC, and Mazurowski, MA. "Relationship between Background Parenchymal Enhancement on High-risk Screening MRI and Future Breast Cancer Risk." Academic Radiology (March 27, 2018).  Full Text
    • Kaunitz, AM, Pinkerton, JV, Ghate, SV, and Wolf, AMD. "Screening mammography for average-risk women." Menopause (New York, N.Y.) 25, no. 3 (March 2018): 343-345.  Full Text
    • Grimm, LJ, Ghate, SV, Hwang, ES, and Soo, MS. "Imaging Features of Patients Undergoing Active Surveillance for Ductal Carcinoma in Situ." Academic radiology 24, no. 11 (November 2017): 1364-1371.  Full Text
    • Grimm, LJ, Johnson, DY, Johnson, KS, Baker, JA, Soo, MS, Hwang, ES, and Ghate, SV. "Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors." European radiology 27, no. 6 (June 2017): 2275-2281.  Full Text
    • Bahl, M, Baker, JA, Bhargavan-Chatfield, M, Brandt, EK, and Ghate, SV. "Impact of Breast Density Notification Legislation on Radiologists' Practices of Reporting Breast Density: A Multi-State Study." Radiology 280, no. 3 (September 2016): 701-706.  Full Text
    • Wang, M, Zhang, J, Grimm, LJ, Ghate, SV, Walsh, R, Johnson, KS, Lo, JY, and Mazurowski, MA. "Predicting false negative errors in digital breast tomosynthesis among radiology trainees using a computer vision-based approach." Expert Systems with Applications 56 (September 2016): 1-8.  Full Text
    • Bahl, M, Pien, IJ, Buretta, KJ, Hwang, ES, Greenup, RA, Ghate, SV, and Hollenbeck, ST. "Can Vascular Patterns on Preoperative Magnetic Resonance Imaging Help Predict Skin Necrosis after Nipple-Sparing Mastectomy?." Journal of the American College of Surgeons 223, no. 2 (August 2016): 279-285.  Full Text
    • Saha, A, Grimm, LJ, Harowicz, M, Ghate, SV, Kim, C, Walsh, R, and Mazurowski, MA. "Interobserver variability in identification of breast tumors in MRI and its implications for prognostic biomarkers and radiogenomics." Medical Physics 43, no. 8 (August 2016): 4558-null.  Full Text
    • Kiarashi, N, Nolte, LW, Lo, JY, Segars, WP, Ghate, SV, Solomon, JB, and Samei, E. "Impact of breast structure on lesion detection in breast tomosynthesis, a simulation study." Journal of Medical Imaging (Bellingham, Wash.) 3, no. 3 (July 2016): 035504-null.  Full Text
    • Bahl, M, Baker, JA, and Ghate, SV. "Reply to "Conventional Ductography Combined With Digital Breast Tomosynthesis for Imaging of Pathologic Nipple Discharge"." Ajr. American Journal of Roentgenology 206, no. 2 (February 2016): W45-null. (Letter)  Full Text
    • Grimm, LJ, Zhang, J, Lo, JY, Johnson, KS, Ghate, SV, Walsh, R, and Mazurowski, MA. "Radiology Trainee Performance in Digital Breast Tomosynthesis: Relationship Between Difficulty and Error-Making Patterns." Journal of the American College of Radiology : JACR 13, no. 2 (February 2016): 198-202.  Full Text
    • Bahl, M, Baker, JA, Greenup, RA, and Ghate, SV. "Evaluation of Pathologic Nipple Discharge: What is the Added Diagnostic Value of MRI?." Annals of surgical oncology 22 Suppl 3 (December 2015): S435-S441.  Full Text
    • Bahl, M, Baker, JA, Kinsey, EN, and Ghate, SV. "Architectural Distortion on Mammography: Correlation With Pathologic Outcomes and Predictors of Malignancy." Ajr. American Journal of Roentgenology 205, no. 6 (December 2015): 1339-1345.  Full Text
    • Mazurowski, MA, Grimm, LJ, Zhang, J, Marcom, PK, Yoon, SC, Kim, C, Ghate, SV, and Johnson, KS. "Recurrence-free survival in breast cancer is associated with MRI tumor enhancement dynamics quantified using computer algorithms." European journal of radiology 84, no. 11 (November 2015): 2117-2122.  Full Text
    • Myers, ER, Moorman, P, Gierisch, JM, Havrilesky, LJ, Grimm, LJ, Ghate, S, Davidson, B, Mongtomery, RC, Crowley, MJ, McCrory, DC, Kendrick, A, and Sanders, GD. "Benefits and Harms of Breast Cancer Screening: A Systematic Review." Jama 314, no. 15 (October 2015): 1615-1634. (Review)  Full Text
    • Grimm, LJ, Soo, MS, Yoon, S, Kim, C, Ghate, SV, and Johnson, KS. "Abbreviated screening protocol for breast MRI: a feasibility study." Academic radiology 22, no. 9 (September 2015): 1157-1162.  Full Text
    • Grimm, LJ, Anderson, AL, Baker, JA, Johnson, KS, Walsh, R, Yoon, SC, and Ghate, SV. "Frequency of Malignancy and Imaging Characteristics of Probably Benign Lesions Seen at Breast MRI." AJR. American journal of roentgenology 205, no. 2 (August 2015): 442-447.  Full Text
    • Bahl, M, Baker, JA, Greenup, RA, and Ghate, SV. "Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge." AJR. American journal of roentgenology 205, no. 1 (July 2015): 203-208.  Full Text
    • Kiarashi, N, Nolte, AC, Sturgeon, GM, Segars, WP, Ghate, SV, Nolte, LW, Samei, E, and Lo, JY. "Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data." Medical Physics 42, no. 7 (July 2015): 4116-4126.  Full Text
    • Zhang, J, Grimm, LJ, Lo, JY, Johnson, KS, Ghate, SV, Walsh, R, and Mazurowski, MA. "Does Breast Imaging Experience During Residency Translate Into Improved Initial Performance in Digital Breast Tomosynthesis?." Journal of the American College of Radiology : JACR 12, no. 7 (July 2015): 728-732.  Full Text
    • Grimm, LJ, Anderson, AL, Baker, JA, Johnson, KS, Walsh, R, Yoon, SC, and Ghate, SV. "Interobserver Variability Between Breast Imagers Using the Fifth Edition of the BI-RADS MRI Lexicon." AJR. American journal of roentgenology 204, no. 5 (May 2015): 1120-1124.  Full Text
    • Mazurowski, MA, Grimm, LJ, Zhang, J, Marcom, PK, Yoon, SC, Kim, C, Ghate, SV, and Johnson, KS. "Recurrence-free survival in breast cancer is associated with MRI tumor enhancement dynamics quantified using computer algorithms." European Journal of Radiology 84, no. 11 (2015): 2117-2122.  Full Text
    • Omonuwa, T, Small, M, and Ghate, S. "Prenatal maternal-fetal imaging for global health radiology." 9781461406044 (October 1, 2014): 219-232. (Chapter)  Full Text
    • Zhang, J, Lo, JY, Kuzmiak, CM, Ghate, SV, Yoon, SC, and Mazurowski, MA. "Using computer-extracted image features for modeling of error-making patterns in detection of mammographic masses among radiology residents." Medical physics 41, no. 9 (September 2014): 091907-.  Full Text
    • Grimm, LJ, Kuzmiak, CM, Ghate, SV, Yoon, SC, and Mazurowski, MA. "Radiology resident mammography training: interpretation difficulty and error-making patterns." Academic radiology 21, no. 7 (July 2014): 888-892.  Full Text
    • Kiarashi, N, Lo, JY, Lin, Y, Ikejimba, LC, Ghate, SV, Nolte, LW, Dobbins, JT, Segars, WP, and Samei, E. "Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems." Ieee Transactions on Medical Imaging 33, no. 7 (July 2014): 1401-1409.  Full Text
    • Ikejimba, LC, Kiarashi, N, Ghate, SV, Samei, E, and Lo, JY. "Task-based strategy for optimized contrast enhanced breast imaging: Analysis of six imaging techniques for mammography and tomosynthesis." Medical Physics 41, no. 6Part1 (May 20, 2014): 061908-061908.  Full Text
    • Grimm, LJ, Ghate, SV, Yoon, SC, Kuzmiak, CM, Kim, C, and Mazurowski, MA. "Predicting error in detecting mammographic masses among radiology trainees using statistical models based on BI-RADS features." Medical physics 41, no. 3 (March 2014): 031909-.  Full Text
    • Grimm, LJ, Ghate, SV, Yoon, SC, Kuzmiak, CM, Kim, C, and Mazurowski, MA. "Predicting error in detecting mammographic masses among radiology trainees using statistical models based on BI-RADS features." Medical Physics 41, no. 3 (February 26, 2014): 031909-031909.  Full Text
    • Ghate, SV, Baker, JA, Kim, CE, Johnson, KS, Walsh, R, and Soo, MSC. "Using the BI-RADS lexicon in a restrictive form of double reading as a strategy for minimizing screening mammography recall rates." Ajr. American Journal of Roentgenology 198, no. 4 (April 2012): 962-970.  Full Text
    • Kiarashi, N, Ghate, SV, Lo, JY, Nolte, LW, and Samei, E. "Application of a dynamic 4D anthropomorphic breast phantom in contrast-based imaging system optimization: Dual-energy or temporal subtraction?." Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7361 LNCS (2012): 658-665.  Full Text
    • Ghate, SV, Baker, JA, Hawkins, AD, and Soher, BJ. "Titanium vs carbon coated ceramic breast tissue marker clips: 3T MR susceptibility artifact and local signal disturbance." Academic Radiology 18, no. 6 (June 2011): 770-773.  Full Text
    • Webb, LJ, Samei, E, Lo, JY, Baker, JA, Ghate, SV, Kim, C, Soo, MS, and Walsh, R. "Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection." Med Phys 38, no. 4 (April 2011): 1972-1980.  Full Text  Link to Item
    • Bennett, LE, Ghate, SV, Bentley, R, and Baker, JA. "Is surgical excision of core biopsy proven benign papillomas of the breast necessary?." Acad Radiol 17, no. 5 (May 2010): 553-557.  Full Text  Link to Item
    • Wilke, LG, Broadwater, G, Rabiner, S, Owens, E, Yoon, S, Ghate, S, Scott, V, Walsh, R, Baker, J, Soo, MS, Ibarra-Drendall, C, Stouder, A, Robertson, S, Barron, A, and Seewaldt, V. "Breast self-examination: defining a cohort still in need." Am J Surg 198, no. 4 (October 2009): 575-579.  Full Text  Link to Item
    • Pollard, BJ, Samei, E, Chawla, AS, Baker, J, Ghate, S, Kim, C, Soo, MS, and Hashimoto, N. "The influence of increased ambient lighting on mass detection in mammograms." Acad Radiol 16, no. 3 (March 2009): 299-304.  Full Text  Link to Item
    • Ghate, SV, Crockett, MM, Boyd, BK, and Paulson, EK. "Sonohysterography: do 3D reconstructed images provide additional value?." AJR Am J Roentgenol 190, no. 4 (April 2008): W227-W233.  Full Text  Link to Item
    • Ghate, SV, Kim, C, Johnson, K, Baker, JA, and Soo, MC. "Minimal Screening Mammography Recall Rates Using Standardized BI-RADS Criteria." AMERICAN JOURNAL OF ROENTGENOLOGY 188, no. 5 (May 2007).  Link to Item
    • Maxwell, RW, Ghate, SV, Bentley, RC, and Soo, MS. "Primary primitive neuroectodermal tumor of the breast." J Ultrasound Med 25, no. 10 (October 2006): 1331-1333.  Link to Item
    • Ghate, SV, Rosen, EL, Soo, MSC, and Baker, JA. "MRI-guided vacuum-assisted breast biopsy with a handheld portable biopsy system." AJR Am J Roentgenol 186, no. 6 (June 2006): 1733-1736.  Full Text  Link to Item
    • Soo, MS, Ghate, SV, Baker, JA, Rosen, EL, Walsh, R, Warwick, BN, Ramachandran, AR, and Nightingale, KR. "Streaming detection for evaluation of indeterminate sonographic breast masses: a pilot study." AJR Am J Roentgenol 186, no. 5 (May 2006): 1335-1341.  Full Text  Link to Item
    • Soo, MS, Ghate, S, Baker, JA, and Rosen, E. "Reply [2]." American Journal of Roentgenology 186, no. 3 (2006): 902-903.  Full Text
    • Ghate, SV, Soo, MS, Baker, JA, Walsh, R, Gimenez, EI, and Rosen, EL. "Comparison of recall and cancer detection rates for immediate versus batch interpretation of screening mammograms." Radiology 235, no. 1 (April 2005): 31-35.  Full Text
    • Soo, MS, Rosen, EL, Xia, JQ, Ghate, S, and Baker, JA. "Computer-aided detection of amorphous calcifications." AJR Am J Roentgenol 184, no. 3 (March 2005): 887-892.  Full Text  Link to Item
    • Soo, MS, Kliewer, MA, Ghate, S, Helsper, RS, and Rosen, EL. "Stereotactic breast biopsy of noncalcified lesions: A cost-minimization analysis comparing 14-gauge multipass automated core biopsy to 14- and 11-gauge vacuum-assisted biopsy." Clinical Imaging 29, no. 1 (2005): 26-33.  Full Text
    • Soo, MS, and Ghate, S. "Herpes simplex virus mastitis: Clinical and imaging findings." American Journal of Roentgenology 174, no. 4 (2000): 1087-1088.
    • Ghate, SV, Soo, MS, and Mengoni, PM. "Extended field-of-view two-dimensional ultrasonography of the breast: improvement in lesion documentation." J Ultrasound Med 18, no. 9 (September 1999): 597-601.  Link to Item
    • Soo, MS, Ghate, S, and Delong, D. "Stereotactic biopsy of noncalcified breast lesions: Utility of vacuum-assisted technique compared to multipass automated gun technique." Clinical Imaging 23, no. 6 (1999): 347-352.  Full Text
    • Pisano, ED, Yankaskas, BC, Ghate, SV, Plankey, MW, and Morgan, JT. "Patient compliance in mobile screening mammography." Acad Radiol 2, no. 12 (December 1995): 1067-1072.  Link to Item
    • George, JW, Ghate, S, Matson, SW, and Besterman, JM. "Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands: Kinetics and specificity." Journal of Biological Chemistry 267, no. 15 (1992): 10683-10689.

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