Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of North Carolina at Chapel Hill 1994
• 

  Duke Appointment History

  • Assistant Professor of Radiology, Radiology, Breast Imaging, Radiology 2012 - 2013
  • Assistant Professor of Radiology, Radiology, Breast Imaging, Radiology 2005 - 2012
  • Associate in the Department of Radiology, Radiology, Breast Imaging, Radiology 2003 - 2005
  • Clinical Associate in the Department of Radiology, Radiology, Breast Imaging, Radiology 2002 - 2003
• Research
• 

  Selected Grants

  • Diagnostic Utility of MRI in Female Patients with Nipple Discharge: A Prospective Trial 2016 - 2020
  • Can contrast dynamics in breast MRI predict genomic intra-tumor heterogeneity 2016 - 2020
  • Machine learning and collaborative filtering tools for personalized education in digital breast tomosynthesis awarded by National Institutes of Health 2016 - 2020
  • Commericialization of a computational imaging-based biomarker for prognostication in breast cancer 2016 - 2017
  • Simultaneous Emission and Transmission Mammotomography awarded by National Institutes of Health 2002 - 2014
• 

  External Relationships

  • Bracco Diagnostics, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Saha, Ashirbani, Lars J. Grimm, Sujata V. Ghate, Connie E. Kim, Mary S. Soo, Sora C. Yoon, and Maciej A. Mazurowski. “Machine learning-based prediction of future breast cancer using algorithmically measured background parenchymal enhancement on high-risk screening MRI.” J Magn Reson Imaging 50, no. 2 (August 2019): 456–64. https://doi.org/10.1002/jmri.26636.
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    • Grimm, Lars J., Ashirbani Saha, Sujata V. Ghate, Connie Kim, Mary Scott Soo, Sora C. Yoon, and Maciej A. Mazurowski. “Relationship between Background Parenchymal Enhancement on High-risk Screening MRI and Future Breast Cancer Risk.” Acad Radiol 26, no. 1 (January 2019): 69–75. https://doi.org/10.1016/j.acra.2018.03.013.
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    • Saha, Ashirbani, Michael R. Harowicz, Lars J. Grimm, Connie E. Kim, Sujata V. Ghate, Ruth Walsh, and Maciej A. Mazurowski. “A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features.” Br J Cancer 119, no. 4 (August 2018): 508–16. https://doi.org/10.1038/s41416-018-0185-8.
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    • Kaunitz, Andrew M., JoAnn V. Pinkerton, Sujata V. Ghate, and Andrew M. D. Wolf. “Screening mammography for average-risk women.” Menopause 25, no. 3 (March 2018): 343–45. https://doi.org/10.1097/GME.0000000000001026.
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    • Grimm, Lars J., Sujata V. Ghate, E Shelley Hwang, and Mary Scott Soo. “Imaging Features of Patients Undergoing Active Surveillance for Ductal Carcinoma in Situ.” Acad Radiol 24, no. 11 (November 2017): 1364–71. https://doi.org/10.1016/j.acra.2017.05.017.
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    • Grimm, Lars J., David Y. Johnson, Karen S. Johnson, Jay A. Baker, Mary Scott Soo, E Shelley Hwang, and Sujata V. Ghate. “Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors.” Eur Radiol 27, no. 6 (June 2017): 2275–81. https://doi.org/10.1007/s00330-016-4617-7.
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    • Bahl, Manisha, Jay A. Baker, Mythreyi Bhargavan-Chatfield, Eugenia K. Brandt, and Sujata V. Ghate. “Impact of Breast Density Notification Legislation on Radiologists' Practices of Reporting Breast Density: A Multi-State Study.” Radiology 280, no. 3 (September 2016): 701–6. https://doi.org/10.1148/radiol.2016152457.
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    • Wang, M., J. Zhang, L. J. Grimm, S. V. Ghate, R. Walsh, K. S. Johnson, J. Y. Lo, and M. A. Mazurowski. “Predicting false negative errors in digital breast tomosynthesis among radiology trainees using a computer vision-based approach.” Expert Systems With Applications 56 (September 1, 2016): 1–8. https://doi.org/10.1016/j.eswa.2016.01.053.
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    • Bahl, Manisha, Irene J. Pien, Kate J. Buretta, E Shelley Hwang, Rachel A. Greenup, Sujata V. Ghate, and Scott T. Hollenbeck. “Can Vascular Patterns on Preoperative Magnetic Resonance Imaging Help Predict Skin Necrosis after Nipple-Sparing Mastectomy?” J Am Coll Surg 223, no. 2 (August 2016): 279–85. https://doi.org/10.1016/j.jamcollsurg.2016.04.045.
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    • Saha, Ashirbani, Lars J. Grimm, Michael Harowicz, Sujata V. Ghate, Connie Kim, Ruth Walsh, and Maciej A. Mazurowski. “Interobserver variability in identification of breast tumors in MRI and its implications for prognostic biomarkers and radiogenomics.” Med Phys 43, no. 8 (August 2016): 4558. https://doi.org/10.1118/1.4955435.
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    • Kiarashi, Nooshin, Loren W. Nolte, Joseph Y. Lo, W Paul Segars, Sujata V. Ghate, Justin B. Solomon, and Ehsan Samei. “Impact of breast structure on lesion detection in breast tomosynthesis, a simulation study.” J Med Imaging (Bellingham) 3, no. 3 (July 2016): 035504. https://doi.org/10.1117/1.JMI.3.3.035504.
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    • Bahl, Manisha, Jay A. Baker, and Sujata V. Ghate. “Reply to "Conventional Ductography Combined With Digital Breast Tomosynthesis for Imaging of Pathologic Nipple Discharge".” Ajr Am J Roentgenol 206, no. 2 (February 2016): W45. https://doi.org/10.2214/AJR.15.15606.
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    • Grimm, Lars J., Jing Zhang, Joseph Y. Lo, Karen S. Johnson, Sujata V. Ghate, Ruth Walsh, and Maciej A. Mazurowski. “Radiology Trainee Performance in Digital Breast Tomosynthesis: Relationship Between Difficulty and Error-Making Patterns.” J Am Coll Radiol 13, no. 2 (February 2016): 198–202. https://doi.org/10.1016/j.jacr.2015.09.025.
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    • Bahl, Manisha, Jay A. Baker, Emily N. Kinsey, and Sujata V. Ghate. “Architectural Distortion on Mammography: Correlation With Pathologic Outcomes and Predictors of Malignancy.” Ajr Am J Roentgenol 205, no. 6 (December 2015): 1339–45. https://doi.org/10.2214/AJR.15.14628.
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    • Bahl, Manisha, Jay A. Baker, Rachel A. Greenup, and Sujata V. Ghate. “Evaluation of Pathologic Nipple Discharge: What is the Added Diagnostic Value of MRI?” Ann Surg Oncol 22 Suppl 3 (December 2015): S435–41. https://doi.org/10.1245/s10434-015-4792-9.
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    • Mazurowski, Maciej A., Lars J. Grimm, Jing Zhang, P Kelly Marcom, Sora C. Yoon, Connie Kim, Sujata V. Ghate, and Karen S. Johnson. “Recurrence-free survival in breast cancer is associated with MRI tumor enhancement dynamics quantified using computer algorithms.” Eur J Radiol 84, no. 11 (November 2015): 2117–22. https://doi.org/10.1016/j.ejrad.2015.07.012.
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    • Myers, Evan R., Patricia Moorman, Jennifer M. Gierisch, Laura J. Havrilesky, Lars J. Grimm, Sujata Ghate, Brittany Davidson, et al. “Benefits and Harms of Breast Cancer Screening: A Systematic Review.” Jama 314, no. 15 (October 20, 2015): 1615–34. https://doi.org/10.1001/jama.2015.13183.
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    • Grimm, Lars J., Mary S. Soo, Sora Yoon, Connie Kim, Sujata V. Ghate, and Karen S. Johnson. “Abbreviated screening protocol for breast MRI: a feasibility study.” Acad Radiol 22, no. 9 (September 2015): 1157–62. https://doi.org/10.1016/j.acra.2015.06.004.
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    • Grimm, Lars J., Andy L. Anderson, Jay A. Baker, Karen S. Johnson, Ruth Walsh, Sora C. Yoon, and Sujata V. Ghate. “Frequency of Malignancy and Imaging Characteristics of Probably Benign Lesions Seen at Breast MRI.” Ajr Am J Roentgenol 205, no. 2 (August 2015): 442–47. https://doi.org/10.2214/AJR.14.13530.
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    • Bahl, Manisha, Jay A. Baker, Rachel A. Greenup, and Sujata V. Ghate. “Diagnostic Value of Ultrasound in Female Patients With Nipple Discharge.” Ajr Am J Roentgenol 205, no. 1 (July 2015): 203–8. https://doi.org/10.2214/AJR.14.13354.
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    • Kiarashi, Nooshin, Adam C. Nolte, Gregory M. Sturgeon, William P. Segars, Sujata V. Ghate, Loren W. Nolte, Ehsan Samei, and Joseph Y. Lo. “Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data.” Med Phys 42, no. 7 (July 2015): 4116–26. https://doi.org/10.1118/1.4919771.
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    • Zhang, Jing, Lars J. Grimm, Joseph Y. Lo, Karen S. Johnson, Sujata V. Ghate, Ruth Walsh, and Maciej A. Mazurowski. “Does Breast Imaging Experience During Residency Translate Into Improved Initial Performance in Digital Breast Tomosynthesis?” Journal of the American College of Radiology : Jacr 12, no. 7 (July 2015): 728–32. https://doi.org/10.1016/j.jacr.2015.02.025.
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    • Grimm, Lars J., Andy L. Anderson, Jay A. Baker, Karen S. Johnson, Ruth Walsh, Sora C. Yoon, and Sujata V. Ghate. “Interobserver Variability Between Breast Imagers Using the Fifth Edition of the BI-RADS MRI Lexicon.” Ajr Am J Roentgenol 204, no. 5 (May 2015): 1120–24. https://doi.org/10.2214/AJR.14.13047.
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    • Omonuwa, T., M. Small, and S. Ghate. “Prenatal maternal-fetal imaging for global health radiology” 9781461406044 (October 1, 2014): 219–32. https://doi.org/10.1007/978-1-4614-0604-4_20.
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    • Zhang, Jing, Joseph Y. Lo, Cherie M. Kuzmiak, Sujata V. Ghate, Sora C. Yoon, and Maciej A. Mazurowski. “Using computer-extracted image features for modeling of error-making patterns in detection of mammographic masses among radiology residents.” Med Phys 41, no. 9 (September 2014): 091907. https://doi.org/10.1118/1.4892173.
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    • Grimm, Lars J., Cherie M. Kuzmiak, Sujata V. Ghate, Sora C. Yoon, and Maciej A. Mazurowski. “Radiology resident mammography training: interpretation difficulty and error-making patterns.” Acad Radiol 21, no. 7 (July 2014): 888–92. https://doi.org/10.1016/j.acra.2014.01.025.
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    • Kiarashi, Nooshin, Joseph Y. Lo, Yuan Lin, Lynda C. Ikejimba, Sujata V. Ghate, Loren W. Nolte, James T. Dobbins, William P. Segars, and Ehsan Samei. “Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems.” Ieee Trans Med Imaging 33, no. 7 (July 2014): 1401–9. https://doi.org/10.1109/TMI.2014.2312733.
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    • Grimm, Lars J., Sujata V. Ghate, Sora C. Yoon, Cherie M. Kuzmiak, Connie Kim, and Maciej A. Mazurowski. “Predicting error in detecting mammographic masses among radiology trainees using statistical models based on BI-RADS features.” Med Phys 41, no. 3 (March 2014): 031909. https://doi.org/10.1118/1.4866379.
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    • Kiarashi, N., S. V. Ghate, J. Y. Lo, L. W. Nolte, and E. Samei. “Application of a dynamic 4D anthropomorphic breast phantom in contrast-based imaging system optimization: Dual-energy or temporal subtraction?” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7361 LNCS (August 15, 2012): 658–65. https://doi.org/10.1007/978-3-642-31271-7_85.
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    • Ghate, Sujata V., Jay A. Baker, Connie E. Kim, Karen S. Johnson, Ruth Walsh, and Mary Scott C. Soo. “Using the BI-RADS lexicon in a restrictive form of double reading as a strategy for minimizing screening mammography recall rates.” Ajr Am J Roentgenol 198, no. 4 (April 2012): 962–70. https://doi.org/10.2214/AJR.11.6648.
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    • Ghate, Sujata V., Jay A. Baker, Ashley D. Hawkins, and Brian J. Soher. “Titanium vs carbon coated ceramic breast tissue marker clips: 3T MR susceptibility artifact and local signal disturbance.” Acad Radiol 18, no. 6 (June 2011): 770–73. https://doi.org/10.1016/j.acra.2011.01.008.
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    • Webb, Lincoln J., Ehsan Samei, Joseph Y. Lo, Jay A. Baker, Sujata V. Ghate, Connie Kim, Mary Scott Soo, and Ruth Walsh. “Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection.” Med Phys 38, no. 4 (April 2011): 1972–80. https://doi.org/10.1118/1.3562901.
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    • Bennett, Lisa E., Sujata V. Ghate, Rex Bentley, and Jay A. Baker. “Is surgical excision of core biopsy proven benign papillomas of the breast necessary?” Acad Radiol 17, no. 5 (May 2010): 553–57. https://doi.org/10.1016/j.acra.2010.01.001.
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    • Wilke, Lee G., Gloria Broadwater, Sarah Rabiner, Elizabeth Owens, Sora Yoon, Sujata Ghate, Victoria Scott, et al. “Breast self-examination: defining a cohort still in need.” Am J Surg 198, no. 4 (October 2009): 575–79. https://doi.org/10.1016/j.amjsurg.2009.06.012.
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    • Pollard, Benjamin J., Ehsan Samei, Amarpreet S. Chawla, Jay Baker, Sujata Ghate, Connie Kim, Mary S. Soo, and Noriyuki Hashimoto. “The influence of increased ambient lighting on mass detection in mammograms.” Acad Radiol 16, no. 3 (March 2009): 299–304. https://doi.org/10.1016/j.acra.2008.08.017.
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    • Ghate, Sujata V., Michele M. Crockett, Brita K. Boyd, and Erik K. Paulson. “Sonohysterography: do 3D reconstructed images provide additional value?” Ajr Am J Roentgenol 190, no. 4 (April 2008): W227–33. https://doi.org/10.2214/AJR.07.2561.
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    • Ghate, S. V., C. Kim, K. Johnson, J. A. Baker, and M. C. Soo. “Minimal Screening Mammography Recall Rates Using Standardized BI-RADS Criteria.” American Journal of Roentgenology 188, no. 5 (May 1, 2007).
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    • Maxwell, Robert W., Sujata V. Ghate, Rex C. Bentley, and Mary Scott Soo. “Primary primitive neuroectodermal tumor of the breast.” J Ultrasound Med 25, no. 10 (October 2006): 1331–33. https://doi.org/10.7863/jum.2006.25.10.1331.
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    • Ghate, Sujata V., Eric L. Rosen, Mary Scott C. Soo, and Jay A. Baker. “MRI-guided vacuum-assisted breast biopsy with a handheld portable biopsy system.” Ajr Am J Roentgenol 186, no. 6 (June 2006): 1733–36. https://doi.org/10.2214/AJR.05.0551.
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    • Soo, Mary Scott, Sujata V. Ghate, Jay A. Baker, Eric L. Rosen, Ruth Walsh, Brenda N. Warwick, A. R. Ramachandran, and Kathryn R. Nightingale. “Streaming detection for evaluation of indeterminate sonographic breast masses: a pilot study.” Ajr Am J Roentgenol 186, no. 5 (May 2006): 1335–41. https://doi.org/10.2214/AJR.05.0005.
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    • Soo, M. S., S. Ghate, J. A. Baker, and E. Rosen. “Reply [2].” American Journal of Roentgenology 186, no. 3 (March 1, 2006): 902–3. https://doi.org/10.2214/AJR.06.5013-1.
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    • Ghate, Sujata V., Mary Scott Soo, Jay A. Baker, Ruth Walsh, Edgardo I. Gimenez, and Eric L. Rosen. “Comparison of recall and cancer detection rates for immediate versus batch interpretation of screening mammograms.” Radiology 235, no. 1 (April 2005): 31–35. https://doi.org/10.1148/radiol.2351040699.
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    • Soo, Mary Scott, Eric L. Rosen, Jessie Q. Xia, Sujata Ghate, and Jay A. Baker. “Computer-aided detection of amorphous calcifications.” Ajr Am J Roentgenol 184, no. 3 (March 2005): 887–92. https://doi.org/10.2214/ajr.184.3.01840887.
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    • Soo, Mary Scott, Mark A. Kliewer, Sujata Ghate, Richard S. Helsper, and Eric L. Rosen. “Stereotactic breast biopsy of noncalcified lesions: a cost-minimization analysis comparing 14-gauge multipass automated core biopsy to 14- and 11-gauge vacuum-assisted biopsy.” Clinical Imaging 29, no. 1 (January 2005): 26–33. https://doi.org/10.1016/j.clinimag.2004.03.007.
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    • Soo, M. S., and S. Ghate. “Herpes simplex virus mastitis: clinical and imaging findings.” Ajr Am J Roentgenol 174, no. 4 (April 2000): 1087–88. https://doi.org/10.2214/ajr.174.4.1741087.
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    • Soo, M. S., S. Ghate, and D. Delong. “Stereotactic biopsy of noncalcified breast lesions: utility of vacuum-assisted technique compared to multipass automated gun technique.” Clinical Imaging 23, no. 6 (November 1999): 347–52. https://doi.org/10.1016/s0899-7071(00)00164-9.
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    • Ghate, S. V., M. S. Soo, and P. M. Mengoni. “Extended field-of-view two-dimensional ultrasonography of the breast: improvement in lesion documentation.” J Ultrasound Med 18, no. 9 (September 1999): 597–601. https://doi.org/10.7863/jum.1999.18.9.597.
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    • Pisano, E. D., B. C. Yankaskas, S. V. Ghate, M. W. Plankey, and J. T. Morgan. “Patient compliance in mobile screening mammography.” Acad Radiol 2, no. 12 (December 1995): 1067–72. https://doi.org/10.1016/s1076-6332(05)80517-3.
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    • George, J. W., S. Ghate, S. W. Matson, and J. M. Besterman. “Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity.” J Biol Chem 267, no. 15 (May 25, 1992): 10683–89.
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  • Conference Papers

    • Saha, A., M. R. Harowicz, L. J. Grimm, C. E. Kim, S. V. Ghate, R. Walsh, and M. A. Mazurowski. “Association of high proliferation marker Ki-67 expression with DCEMR imaging features of breast: A large scale evaluation.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 10575, 2018. https://doi.org/10.1117/12.2293207.
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    • Zhang, J., S. V. Ghate, L. J. Grimm, A. Saha, E. H. Cain, Z. Zhu, and M. A. Mazurowski. “Convolutional encoder-decoder for breast mass segmentation in digital breast tomosynthesis.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 10575, 2018. https://doi.org/10.1117/12.2295437.
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    • Wang, M., J. Zhang, L. J. Grimm, S. V. Ghate, R. Walsh, K. S. Johnson, J. Y. Lo, and M. A. Mazurowski. “Identification of error making patterns in lesion detection on digital breast tomosynthesis using computer-extracted image features.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 9787, 2016. https://doi.org/10.1117/12.2201061.
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    • Pien, Irene J., Manisha Bahl, Kate J. Buretta, Rachel A. Greenup, Sujata V. Ghate, and Scott T. Hollenbeck. “Vascular Patterns on Preoperative Breast MRI Predict Ischemia and Necrosis after Nipple-Sparing Mastectomy.” In Journal of the American College of Surgeons, 221:S120–S120. Elsevier BV, 2015. https://doi.org/10.1016/j.jamcollsurg.2015.07.282.
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    • Kiarashi, N., L. W. Nolte, J. Y. Lo, W. P. Segars, S. V. Ghate, and E. Samei. “The impact of breast structure on lesion detection in breast tomosynthesis.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 9412, 2015. https://doi.org/10.1117/12.2082473.
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    • Ikejimba, Lynda C., Nooshin Kiarashi, Sujata V. Ghate, Ehsan Samei, and Joseph Y. Lo. “Task-based strategy for optimized contrast enhanced breast imaging: analysis of six imaging techniques for mammography and tomosynthesis.” In Med Phys, 41:061908, 2014. https://doi.org/10.1118/1.4873317.
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    • Mazurowski, M. A., J. Zhang, J. Y. Lo, C. M. Kuzmiak, S. V. Ghate, and S. Yoon. “Modeling resident error-making patterns in detection of mammographic masses using computer-extracted image features: Preliminary experiments.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 9037, 2014. https://doi.org/10.1117/12.2044404.
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    • Kiarashi, N., Y. Lin, W. P. Segars, S. V. Ghate, L. Ikejimba, B. Chen, J. Y. Lo, J. T. Dobbins, L. W. Nolte, and E. Samei. “Development of a dynamic 4D anthropomorphic breast phantom for contrast-based breast imaging.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 8313, 2012. https://doi.org/10.1117/12.913332.
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    • Lin, Y., S. Ghate, J. Lo, and E. Samei. “3D biopsy for tomosynthesis: Simulation of prior information based reconstruction for dose and artifact reduction.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 8313, 2012. https://doi.org/10.1117/12.912346.
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    • Ghate, S. V., and E. L. Rosen. “MRI-guided breast biopsies using a novel hand-held portable breast biopsy system.” In American Journal of Roentgenology, 184:58–58. AMER ROENTGEN RAY SOC, 2005.
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    • Soo, M. S., J. A. Baker, S. V. Ghate, R. Walsh, B. Warwick, and K. Nightingale. “Streaming detection for evaluation of indeterminate sono-graphic breast masses - A pilot study.” In American Journal of Roentgenology, 184:27–27. AMER ROENTGEN RAY SOC, 2005.
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