Joseph Alan Govert | Scholars@Duke

Joseph Alan Govert
Professor of Medicine

I am trying to focus my research efforts in two specific areas, the medical intensive care unit, and clinical lung cancer research. Within the intensive care unit I am specifically interested in clinical trials and outcome evaluation. My interest in lung cancer centers on the clinical and cost effectiveness of various diagnostic procedures.

In the intensive care unit I am specifically involved in clinical trials for the adult respiratory distress syndrome (ARDS). At the present time I am on the steering committee for the NIH ARDS clinical trial network. We are currently enrolling patients in clinical protocols studying the effects of ventilator strategies, as well as novel therapeutic agents in the outcome of ARDS. I am also interested in ICU outcome research including statistical modeling of ICU outcomes.

My interest in lung cancer research centers on evaluating the efficacy of diagnostic tests in the diagnosis of pulmonary malignancy. I have retrospectively and prospectively evaluated brochoscopic procedures, comparing the sensitivity and specificity of various techniques as well as their cost-effectiveness. I am also currently analyzing the clinical utility and cost-effectiveness of positron emission tomography in the diagnosis of lung cancer.

Key words: clinical trials, medical intensive care, lung cancer diagnostic testing

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2018

Contact Information

6 East, Room 42, Duke Medical Pavillion, Durham, NC 27710
Duke Box 100805, Durham, NC 27710
gover001@mc.duke.edu (919) 681-5919

Background
Education, Training, & Certifications
- Fellow in Pulmonary Medicine, Medicine, Duke University 1993 - 1996
- Resident, Medicine, Duke University 1989 - 1992
- M.D., University of California at Irvine 1989
Duke Appointment History
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2009 - 2018
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2005 - 2008
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1999 - 2005
- Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1996 - 1999
Research
Selected Grants
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
- Early Rehabilitation in Critical Care-Supine Cycling and Functional Electrical Stimulation awarded by American Thoracic Society 2014 - 2015
- SAILS awarded by National Institutes of Health 2010 - 2014
- Measuring/Improving Quality of Life in Acute Lung Injury awarded by National Institutes of Health 2005 - 2010
- Treatment of Pulmonary Disease Following Spinal Cord Injury awarded by National Institutes of Health 1999 - 2001
- The study of new therapies for sarcoidosis awarded by The Mary Duke Biddle Foundation 1998 - 1999
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Grissom, Colin K., Eliotte L. Hirshberg, Justin B. Dickerson, Samuel M. Brown, Michael J. Lanspa, Kathleen D. Liu, David Schoenfeld, et al. “Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*..” Critical Care Medicine 43, no. 2 (February 2015): 288–95. https://doi.org/10.1097/CCM.0000000000000715.
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  - Schell-Chaple, Hildy M., Kathleen A. Puntillo, Michael A. Matthay, Kathleen D. Liu, and Kathleen D. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. “Body temperature and mortality in patients with acute respiratory distress syndrome..” American Journal of Critical Care : An Official Publication, American Association of Critical Care Nurses 24, no. 1 (January 2015): 15–23. https://doi.org/10.4037/ajcc2015320.
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  - Catania, Jelena, Loretta G. Que, Joseph A. Govert, John W. Hollingsworth, and Cameron R. Wolfe. “High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination..” American Journal of Respiratory and Critical Care Medicine 189, no. 4 (February 2014): 485–87. https://doi.org/10.1164/rccm.201401-0066LE.
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  - Rosoff, Philip M., Kuldip R. Patel, Ann Scates, Gene Rhea, Paul W. Bush, and Joseph A. Govert. “Coping with critical drug shortages: an ethical approach for allocating scarce resources in hospitals..” Archives of Internal Medicine 172, no. 19 (October 2012): 1494–99. https://doi.org/10.1001/archinternmed.2012.4367.
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  - Turner, David A., Walter L. Williford, Michelle A. Peters, Janice J. Thalman, Ian R. Shearer, Richard J. Walczak, Michael Griffis, et al. “Development of a collaborative program to provide extracorporeal membrane oxygenation for adults with refractory hypoxemia within the framework of a pandemic..” Pediatric Critical Care Medicine : A Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 12, no. 4 (July 2011): 426–30. https://doi.org/10.1097/pcc.0b013e3181ff41c1.
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  - Norfolk, Stephanie G., Caroline L. Hollingsworth, Cameron R. Wolfe, Joseph A. Govert, Loretta G. Que, Ira M. Cheifetz, and John W. Hollingsworth. “Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009..” Critical Care Medicine 38, no. 11 (November 2010): 2103–7. https://doi.org/10.1097/CCM.0b013e3181f268f1.
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  - Unroe, Mark, Jeremy M. Kahn, Shannon S. Carson, Joseph A. Govert, Tereza Martinu, Shailaja J. Sathy, Alison S. Clay, et al. “One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study..” Annals of Internal Medicine 153, no. 3 (August 2010): 167–75. https://doi.org/10.1059/0003-4819-153-3-201008030-00007.
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  - Cox, Christopher E., and Joseph A. Govert. “Assessing the comparative value of sedatives in the intensive care unit..” Critical Care Medicine 38, no. 2 (February 2010): 709–11. https://doi.org/10.1097/ccm.0b013e3181bfeaf7.
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  - Cox, Christopher E., Tereza Martinu, Shailaja J. Sathy, Alison S. Clay, Jessica Chia, Alice L. Gray, Maren K. Olsen, Joseph A. Govert, Shannon S. Carson, and James A. Tulsky. “Expectations and outcomes of prolonged mechanical ventilation..” Critical Care Medicine 37, no. 11 (November 2009): 2888–2904. https://doi.org/10.1097/CCM.0b013e3181ab86ed.
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  - Carson, Shannon S., Joanne Garrett, Laura C. Hanson, Joyce Lanier, Joe Govert, Mary C. Brake, Dante L. Landucci, Christopher E. Cox, and Timothy S. Carey. “A prognostic model for one-year mortality in patients requiring prolonged mechanical ventilation..” Crit Care Med 36, no. 7 (July 2008): 2061–69. https://doi.org/10.1097/CCM.0b013e31817b8925.
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  - Phua, Ghee-Chee, and Joseph Govert. “Mechanical ventilation in an airborne epidemic..” Clinics in Chest Medicine 29, no. 2 (June 2008): 323–vii. https://doi.org/10.1016/j.ccm.2008.01.001.
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  - Cox, Christopher E., Shelby D. Reed, Joseph A. Govert, Jo E. Rodgers, Stacy Campbell-Bright, John P. Kress, and Shannon S. Carson. “Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation..” Crit Care Med 36, no. 3 (March 2008): 706–14. https://doi.org/10.1097/CCM.0B013E3181544248.
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  - Reddy, Anita J., Joseph A. Govert, Thomas A. Sporn, and Momen M. Wahidi. “Broncholith removal using cryotherapy during flexible bronchoscopy: a case report..” Chest 132, no. 5 (November 2007): 1661–63. https://doi.org/10.1378/chest.07-0739.
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  - Clay, A. S., L. G. Que, J. A. Govert, and K. M. Andolsek. “"A rose by any other name"? Toward a common terminology in simulation education and assessment [6].” Critical Care Medicine 35, no. 9 (September 1, 2007). https://doi.org/10.1097/01.CCM.0000281641.66736.90.
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  - Wahidi, Momen M., Joseph A. Govert, Ranjit K. Goudar, Michael K. Gould, Douglas C. McCrory, and Douglas C. American College of Chest Physicians. “Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition)..” Chest 132, no. 3 Suppl (September 2007): 94S-107S. https://doi.org/10.1378/chest.07-1352.
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  - Cox, Christopher E., Shannon S. Carson, Joseph A. Govert, Lakshmipathi Chelluri, and Gillian D. Sanders. “An economic evaluation of prolonged mechanical ventilation..” Crit Care Med 35, no. 8 (August 2007): 1918–27. https://doi.org/10.1097/01.CCM.0000275391.35834.10.
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  - Clay, Alison S., Loretta Que, Emil R. Petrusa, Mark Sebastian, and Joseph Govert. “Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching..” Critical Care Medicine 35, no. 3 (March 2007): 738–54. https://doi.org/10.1097/01.ccm.0000257329.22025.18.
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  - McClintock, Dana E., Lorraine B. Ware, Mark D. Eisner, Nancy Wickersham, B Taylor Thompson, Michael A. Matthay, and Michael A. National Heart, Lung, and Blood Institute ARDS Network. “Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury..” American Journal of Respiratory and Critical Care Medicine 175, no. 3 (February 2007): 256–62. https://doi.org/10.1164/rccm.200607-947OC.
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  - Cox, Christopher E., Shannon S. Carson, Jennifer H. Lindquist, Maren K. Olsen, Joseph A. Govert, Lakshmipathi Chelluri, and Lakshmipathi Quality of Life After Mechanical Ventilation in the Aged (QOL-MV) Investigators. “Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study..” Critical Care (London, England) 11, no. 1 (January 2007). https://doi.org/10.1186/cc5667.
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  - McClintock, Dana E., Barry Starcher, Mark D. Eisner, B Taylor Thompson, Doug L. Hayden, Gwynne D. Church, Michael A. Matthay, and Michael A. National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. “Higher urine desmosine levels are associated with mortality in patients with acute lung injury..” American Journal of Physiology. Lung Cellular and Molecular Physiology 291, no. 4 (October 2006): L566–71. https://doi.org/10.1152/ajplung.00457.2005.
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  - Roggli, Victor L., Claude A. Piantadosi, Neil R. MacIntyre, Stephen L. Young, Peter S. Kussin, Mark P. Steele, Martha Sue Carraway, et al. “Physician subsidies for tobacco advertising..” American Journal of Respiratory and Critical Care Medicine 173, no. 2 (January 2006). https://doi.org/10.1164/ajrccm.173.2.246.
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  - Cox, C. E., J. A. Govert, H. Shanawani, and A. P. Abernethy. “Providing palliative care for patients receiving mechanical ventilation in an intensive care unit: Part 2: Withdrawing ventilation.” Progress in Palliative Care 13, no. 3 (September 21, 2005): 133–37. https://doi.org/10.1179/096992605X48642.
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  - Cox, C. E., J. A. Govert, H. Shanawani, and A. P. Abernethy. “Providing palliative care for patients receiving mechanical ventilation. Part I: Invasive and non-invasive ventilation.” Progress in Palliative Care 13, no. 2 (June 30, 2005): 63–69. https://doi.org/10.1179/096992605X42404.
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  - Wahidi, Momen M., Ana T. Rocha, John W. Hollingsworth, Joseph A. Govert, David Feller-Kopman, and Armin Ernst. “Contraindications and safety of transbronchial lung biopsy via flexible bronchoscopy. A survey of pulmonologists and review of the literature..” Respiration; International Review of Thoracic Diseases 72, no. 3 (May 2005): 285–95. https://doi.org/10.1159/000085370.
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  - Govert, Joseph A. “Another excuse bites the dust: low tidal volume ventilation does not increase sedation use..” Critical Care Medicine 33, no. 4 (April 2005): 903–4. https://doi.org/10.1097/01.ccm.0000159693.52183.2e.
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  - Hadjiliadis, Denis, Mark P. Steele, Joseph A. Govert, R Duane Davis, and Scott M. Palmer. “Outcome of lung transplant patients admitted to the medical ICU..” Chest 125, no. 3 (March 2004): 1040–45.
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  - Maccioli, Gerald A., Todd Dorman, Brent R. Brown, John E. Mazuski, Barbara A. McLean, Joanne M. Kuszaj, Stanley H. Rosenbaum, et al. “Clinical practice guidelines for the maintenance of patient physical safety in the intensive care unit: use of restraining therapies--American College of Critical Care Medicine Task Force 2001-2002..” Critical Care Medicine 31, no. 11 (November 2003): 2665–76. https://doi.org/10.1097/01.ccm.0000095463.72353.ad.
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  - Cox, Christopher E., Shannon S. Carson, E Wesley Ely, Joseph A. Govert, Joanne M. Garrett, Roy G. Brower, David G. Morris, et al. “Effectiveness of medical resident education in mechanical ventilation..” American Journal of Respiratory and Critical Care Medicine 167, no. 1 (January 2003): 32–38. https://doi.org/10.1164/rccm.200206-624oc.
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  - Ahearn, Gregory S., Denis Hadjiliadis, Joseph A. Govert, and Victor F. Tapson. “Massive pulmonary embolism during pregnancy successfully treated with recombinant tissue plasminogen activator: a case report and review of treatment options..” Archives of Internal Medicine 162, no. 11 (June 2002): 1221–27. https://doi.org/10.1001/archinte.162.11.1221.
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  - Samsa, Gregory P., Joseph Govert, David B. Matchar, and Douglas C. McCrory. “Use of data from nonrandomized trial designs in evidence reports: an application to treatment of pulmonary disease following spinal cord injury..” Journal of Rehabilitation Research and Development 39, no. 1 (January 2002): 41–52.
  - Wahidi, M. M., J. Sago, J. A. Govert, and E. G. Schreiber. “Upper airway obstruction in a patient with epidermolysis bullosa acquisita.” Journal of Bronchology 9, no. 4 (January 1, 2002): 298–300. https://doi.org/10.1097/00128594-200210000-00008.
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  - McCrory, D. C., G. P. Samsa, B. B. Hamilton, J. A. Govert, D. B. Matchar, R. E. Goslin, and J. T. Kolimaga. “Treatment of pulmonary disease following cervical spinal cord injury..” Evidence Report/Technology Assessment (Summary), no. 27 (June 2001): 1–4.
  - Hadjiliadis, D., and J. A. Govert. “Methemoglobinemia after infusion of ifosfamide chemotherapy: first report of a potentially serious adverse reaction related to ifosfamide..” Chest 118, no. 4 (October 2000): 1208–10.
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  - Ahearn, G. S., D. Hadjiliadis, V. F. Tapson, and J. A. Govert. “Thrombolytic therapy with tissue plasminogen activator (TPA) in the first trimester of pregnancy after massive pulmonary embolism (PE).” Chest 116, no. 4 SUPPL. 2 (December 1, 1999).
  - Hadjiliadis, D., and J. A. Govert. “Methemoglobinemia after infusion of ifosfamide chemotherapy.” Chest 116, no. 4 SUPPL. 2 (December 1, 1999).
  - Govert, J. A., L. G. Dodd, P. S. Kussin, and W. M. Samuelson. “A prospective comparison of fiberoptic transbronchial needle aspiration and bronchial biopsy for bronchoscopically visible lung carcinoma..” Cancer 87, no. 3 (June 1999): 129–34. https://doi.org/10.1002/(sici)1097-0142(19990625)87:3<129::aid-cncr5>3.0.co;2-g.
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  - Baz, M. A., D. T. Layisch, J. A. Govert, D. N. Howell, C. M. Lawrence, R. D. Davis, and V. F. Tapson. “Diagnostic yield of bronchoscopies after isolated lung transplantation.” Pneumologie 51, no. 3 (December 1, 1997).
  - Chau, C. H., W. W. Yeu, P. C. Wong, J. Lee, and C. F. Wong. “Usefulness of collecting routine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible and nonvisible lung carcinoma..” Chest 111, no. 2 (February 1997): 522–23. https://doi.org/10.1378/chest.111.2.522.
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  - Layish Daniel, T., J. A. Govert, and R. A. Radtke. “Physician practices in the diagnostic evaluation of suspected Obstructive Sleep Apnea (OSA).” Chest 110, no. 4 SUPPL. (October 1, 1996).
  - Layish Daniel, T., J. A. Govert, and R. A. Radtke. “Variation in physician threshold to treat Obstructive Sleep Apnea (OSA).” Chest 110, no. 4 SUPPL. (October 1, 1996).
  - Govert, J. A., J. M. Kopita, D. Matchar, P. S. Kussin, and W. M. Samuelson. “Cost-effectiveness of collecting routine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible lung tumor..” Chest 109, no. 2 (February 1996): 451–56. https://doi.org/10.1378/chest.109.2.451.
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  - Friedman, H. S. “Treatment of acute myocardial infarction..” The New England Journal of Medicine 329, no. 6 (August 1993): 430–31. https://doi.org/10.1056/nejm199308053290613.
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  - Govert, J. A., S. Patton, and R. L. Fine. “Pancytopenia from using trimethoprim and methotrexate..” Annals of Internal Medicine 117, no. 10 (November 1992): 877–78. https://doi.org/10.7326/0003-4819-117-10-877_2.
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Teaching & Mentoring
Recent Courses
- MEDICINE 405C: Intensive Care Medicine Sub-Internship (Duke) 2017

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Recent Courses