Joseph Alan Govert | Scholars@Duke

Joseph Alan Govert
Professor of Medicine

I am trying to focus my research efforts in two specific areas, the medical intensive care unit, and clinical lung cancer research. Within the intensive care unit I am specifically interested in clinical trials and outcome evaluation. My interest in lung cancer centers on the clinical and cost effectiveness of various diagnostic procedures.

In the intensive care unit I am specifically involved in clinical trials for the adult respiratory distress syndrome (ARDS). At the present time I am on the steering committee for the NIH ARDS clinical trial network. We are currently enrolling patients in clinical protocols studying the effects of ventilator strategies, as well as novel therapeutic agents in the outcome of ARDS. I am also interested in ICU outcome research including statistical modeling of ICU outcomes.

My interest in lung cancer research centers on evaluating the efficacy of diagnostic tests in the diagnosis of pulmonary malignancy. I have retrospectively and prospectively evaluated brochoscopic procedures, comparing the sensitivity and specificity of various techniques as well as their cost-effectiveness. I am also currently analyzing the clinical utility and cost-effectiveness of positron emission tomography in the diagnosis of lung cancer.

Key words: clinical trials, medical intensive care, lung cancer diagnostic testing

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2018

Contact Information

6 East, Room 42, Duke Medical Pavillion, Durham, NC 27710
Duke Box 100805, Durham, NC 27710
gover001@mc.duke.edu (919) 681-5919

Background
Education, Training, & Certifications
- Fellow in Pulmonary Medicine, Medicine, Duke University 1993 - 1996
- Resident, Medicine, Duke University 1989 - 1992
- M.D., University of California at Irvine 1989
Duke Appointment History
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2009 - 2018
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2005 - 2008
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1999 - 2005
- Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1996 - 1999
Research
Selected Grants
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
- Early Rehabilitation in Critical Care-Supine Cycling and Functional Electrical Stimulation awarded by American Thoracic Society 2014 - 2015
- SAILS awarded by National Institutes of Health 2010 - 2014
- Measuring/Improving Quality of Life in Acute Lung Injury awarded by National Institutes of Health 2005 - 2010
- Treatment of Pulmonary Disease Following Spinal Cord Injury awarded by National Institutes of Health 1999 - 2001
- The study of new therapies for sarcoidosis awarded by The Mary Duke Biddle Foundation 1998 - 1999
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Grissom, CK, Hirshberg, EL, Dickerson, JB, Brown, SM, Lanspa, MJ, Liu, KD, Schoenfeld, D, Tidswell, M, Hite, RD, Rock, P, Miller, RR, Morris, AH, and National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network, . "Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*." Critical care medicine 43, no. 2 (February 2015): 288-295. Full Text
  - Schell-Chaple, HM, Puntillo, KA, Matthay, MA, Liu, KD, National Heart, Lung, and and Blood Institute Acute Respiratory Distress Syndrome Network, . "Body temperature and mortality in patients with acute respiratory distress syndrome." American journal of critical care : an official publication, American Association of Critical-Care Nurses 24, no. 1 (January 2015): 15-23. Full Text
  - Catania, J, Que, LG, Govert, JA, Hollingsworth, JW, and Wolfe, CR. "High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination." American journal of respiratory and critical care medicine 189, no. 4 (February 2014): 485-487. (Letter) Full Text
  - Rosoff, PM, Patel, KR, Scates, A, Rhea, G, Bush, PW, and Govert, JA. "Coping with critical drug shortages: an ethical approach for allocating scarce resources in hospitals." Arch Intern Med 172, no. 19 (October 22, 2012): 1494-1499. (Review) Full Text Link to Item
  - Turner, DA, Williford, WL, Peters, MA, Thalman, JJ, Shearer, IR, Walczak, RJ, Griffis, M, Olson, SA, Sowers, KW, Govert, JA, Macintyre, NR, and Cheifetz, IM. "Development of a collaborative program to provide extracorporeal membrane oxygenation for adults with refractory hypoxemia within the framework of a pandemic." Pediatr Crit Care Med 12, no. 4 (July 2011): 426-430. Full Text Link to Item
  - Norfolk, SG, Hollingsworth, CL, Wolfe, CR, Govert, JA, Que, LG, Cheifetz, IM, and Hollingsworth, JW. "Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009." Crit Care Med 38, no. 11 (November 2010): 2103-2107. Full Text Link to Item
  - Unroe, M, Kahn, JM, Carson, SS, Govert, JA, Martinu, T, Sathy, SJ, Clay, AS, Chia, J, Gray, A, Tulsky, JA, and Cox, CE. "One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study." Ann Intern Med 153, no. 3 (August 3, 2010): 167-175. Full Text Link to Item
  - Cox, CE, and Govert, JA. "Assessing the comparative value of sedatives in the intensive care unit." Crit Care Med 38, no. 2 (February 2010): 709-711. Full Text Link to Item
  - Cox, CE, Martinu, T, Sathy, SJ, Clay, AS, Chia, J, Gray, AL, Olsen, MK, Govert, JA, Carson, SS, and Tulsky, JA. "Expectations and outcomes of prolonged mechanical ventilation." Crit Care Med 37, no. 11 (November 2009): 2888-2894. Full Text Link to Item
  - Carson, SS, Garrett, J, Hanson, LC, Lanier, J, Govert, J, Brake, MC, Landucci, DL, Cox, CE, and Carey, TS. "A prognostic model for one-year mortality in patients requiring prolonged mechanical ventilation." Crit Care Med 36, no. 7 (July 2008): 2061-2069. Full Text Link to Item
  - Cox, CE, Reed, SD, Govert, JA, Rodgers, JE, Campbell-Bright, S, Kress, JP, and Carson, SS. "Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation." Crit Care Med 36, no. 3 (March 2008): 706-714. (Review) Full Text Link to Item
  - Phua, G-C, and Govert, J. "Mechanical Ventilation in an Airborne Epidemic." Clinics in Chest Medicine 29, no. 2 (2008): 323-328. Full Text
  - Reddy, AJ, Govert, JA, Sporn, TA, and Wahidi, MM. "Broncholith removal using cryotherapy during flexible bronchoscopy: a case report." Chest 132, no. 5 (November 2007): 1661-1663. Full Text Link to Item
  - Wahidi, MM, Govert, JA, Goudar, RK, Gould, MK, McCrory, DC, and American College of Chest Physicians, . "Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition)." Chest 132, no. 3 Suppl (September 2007): 94S-107S. (Review) Full Text Link to Item
  - Cox, CE, Carson, SS, Govert, JA, Chelluri, L, and Sanders, GD. "An economic evaluation of prolonged mechanical ventilation." Crit Care Med 35, no. 8 (August 2007): 1918-1927. Full Text Link to Item
  - Clay, AS, Que, L, Petrusa, ER, Sebastian, M, and Govert, J. "Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching." Crit Care Med 35, no. 3 (March 2007): 738-754. Full Text Link to Item
  - Clay, AS, Que, LG, Govert, JA, and Andolsek, KM. ""A rose by any other name"? Toward a common terminology in simulation education and assessment [6]." Critical Care Medicine 35, no. 9 (2007): 2238--. Full Text
  - Cox, CE, Carson, SS, Lindquist, JH, Olsen, MK, Govert, JA, Chelluri, L, and Quality of Life After Mechanical Ventilation in the Aged (QOL-MV) Investigators, . "Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study." Crit Care 11, no. 1 (2007): R9-. Full Text Link to Item
  - McClintock, DE, Ware, LB, Eisner, MD, Wickersham, N, Thompson, BT, Matthay, MA, Wiedemann, HP, Arroliga, AC, Jr, CJF, Jr, JJK, Periz-Trepichio, P, Parsons, PE, Welsh, C, Jr, WJF, MacIntyre, N, Mallatratt, L, Sebastian, M, Davies, J, Dyne, EV, Govert, J, Sevransky, J, Murray, S, Brower, RG, Thompson, D, Fessler, HE, Morris, AH, Clemmer, T, Davis, R, Jr, JO, Weaver, L, Grissom, C, Thomas, F, Gleich, M, Lawton, C, D'Hulst, J, Peerless, JR, Smith, C, Kallet, R, Luce, JM, Gottlieb, J, and Park, P et al. "Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury." American Journal of Respiratory and Critical Care Medicine 175, no. 3 (2007): 256-262. Full Text
  - Roggli, VL, Piantadosi, CA, MacIntyre, NR, Young, SL, Kussin, PS, Steele, MP, Carraway, MS, Welty-Wolf, KE, Govert, JA, McMahon, TJ, Palmer, SM, Sporn, TA, and Ghio, AJ. "Physician subsidies for tobacco advertising." Am J Respir Crit Care Med 173, no. 2 (January 15, 2006): 246-. (Letter) Full Text Link to Item
  - McClintock, DE, Starcher, B, Eisner, MD, Thompson, BT, Hayden, DL, Church, GD, Matthay, MA, Wiedemann, HP, Arroliga, AC, Jr, CJF, Jr, JJK, Periz-Trepichio, P, Parsons, PE, Welsh, C, Jr, WJF, MacIntyre, N, Mallatratt, L, Sebastian, M, Davies, J, Dyne, EV, Govert, J, Sevransky, J, Murray, S, Brower, RG, Thompson, D, Fessler, HE, Morris, AH, Clemmer, T, Davis, R, Jr, JO, Weaver, L, Grissom, C, Thomas, F, Gleich, M, Lawton, C, D'Hulst, J, Peerless, JR, Smith, C, Kallet, R, Luce, JM, and Gottlieb, J et al. "Higher urine desmosine levels are associated with mortality in patients with acute lung injury." American Journal of Physiology - Lung Cellular and Molecular Physiology 291, no. 4 (2006): L566-L571. Full Text
  - Wahidi, MM, Rocha, AT, Hollingsworth, JW, Govert, JA, Feller-Kopman, D, and Ernst, A. "Contraindications and safety of transbronchial lung biopsy via flexible bronchoscopy. A survey of pulmonologists and review of the literature." Respiration 72, no. 3 (May 2005): 285-295. Full Text Link to Item
  - Govert, JA. "Another excuse bites the dust: low tidal volume ventilation does not increase sedation use." Crit Care Med 33, no. 4 (April 2005): 903-904. Link to Item
  - Cox, CE, Govert, JA, Shanawani, H, and Abernethy, AP. "Providing palliative care for patients receiving mechanical ventilation in an intensive care unit: Part 2: Withdrawing ventilation." Progress in Palliative Care 13, no. 3 (2005): 133-137. Full Text
  - Cox, CE, Govert, JA, Shanawani, H, and Abernethy, AP. "Providing palliative care for patients receiving mechanical ventilation. Part I: Invasive and non-invasive ventilation." Progress in Palliative Care 13, no. 2 (2005): 63-69. Full Text
  - Hadjiliadis, D, Steele, MP, Govert, JA, Davis, RD, and Palmer, SM. "Outcome of lung transplant patients admitted to the medical ICU." Chest 125, no. 3 (March 2004): 1040-1045. Link to Item
  - Maccioli, GA, Dorman, T, Brown, BR, Mazuski, JE, McLean, BA, Kuszaj, JM, Rosenbaum, SH, Frankel, LR, Devlin, JW, Govert, JA, Smith, B, Peruzzi, WT, American College of Critical Care Medicine, and Society of Critical Care Medicine, . "Clinical practice guidelines for the maintenance of patient physical safety in the intensive care unit: use of restraining therapies--American College of Critical Care Medicine Task Force 2001-2002." Crit Care Med 31, no. 11 (November 2003): 2665-2676. (Review) Full Text Link to Item
  - Cox, CE, Carson, SS, Ely, EW, Govert, JA, Garrett, JM, Brower, RG, Morris, DG, Abraham, E, Donnabella, V, Spevetz, A, and Hall, JB. "Effectiveness of medical resident education in mechanical ventilation." Am J Respir Crit Care Med 167, no. 1 (January 1, 2003): 32-38. Full Text Link to Item
  - Ahearn, GS, Hadjiliadis, D, Govert, JA, and Tapson, VF. "Massive pulmonary embolism during pregnancy successfully treated with recombinant tissue plasminogen activator: a case report and review of treatment options." Arch Intern Med 162, no. 11 (June 10, 2002): 1221-1227. Link to Item
  - Samsa, GP, Govert, J, Matchar, DB, and McCrory, DC. "Use of data from nonrandomized trial designs in evidence reports: an application to treatment of pulmonary disease following spinal cord injury." J Rehabil Res Dev 39, no. 1 (January 2002): 41-52. Link to Item
  - Wahidi, MM, Sago, J, Govert, JA, and Schreiber, EG. "Upper airway obstruction in a patient with epidermolysis bullosa acquisita." Journal of Bronchology 9, no. 4 (2002): 298-300.
  - McCrory, DC, Samsa, GP, Hamilton, BB, Govert, JA, Matchar, DB, Goslin, RE, and Kolimaga, JT. "Treatment of pulmonary disease following cervical spinal cord injury." Evid Rep Technol Assess (Summ) , no. 27 (June 2001): 1-4. (Review) Link to Item
  - Hadjiliadis, D, and Govert, JA. "Methemoglobinemia after infusion of ifosfamide chemotherapy: first report of a potentially serious adverse reaction related to ifosfamide." Chest 118, no. 4 (October 2000): 1208-1210. Link to Item
  - Govert, JA, Dodd, LG, Kussin, PS, and Samuelson, WM. "A prospective comparison of fiberoptic transbronchial needle aspiration and bronchial biopsy for bronchoscopically visible lung carcinoma." Cancer 87, no. 3 (June 25, 1999): 129-134. Link to Item
  - Ahearn, GS, Hadjiliadis, D, Tapson, VF, and Govert, JA. "Thrombolytic therapy with tissue plasminogen activator (TPA) in the first trimester of pregnancy after massive pulmonary embolism (PE)." Chest 116, no. 4 SUPPL. 2 (1999): 405S-.
  - Hadjiliadis, D, and Govert, JA. "Methemoglobinemia after infusion of ifosfamide chemotherapy." Chest 116, no. 4 SUPPL. 2 (1999): 419S-.
  - Baz, MA, Layisch, DT, Govert, JA, Howell, DN, Lawrence, CM, Davis, RD, and Tapson, VF. "Diagnostic yield of bronchoscopies after isolated lung transplantation." Pneumologie 51, no. 3 (1997): 262--.
  - Chau, CH, Yue, WW, Wong, PC, Lee, J, Wong, CF, Govert, JA, Kussin, PS, and Samuelson, W. "Usefulness of collecting routine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible and nonvisible lung carcinoma [1] (multiple letters)." Chest 111, no. 2 (1997): 522-523.
  - Govert, JA, Kopita, JM, Matchar, D, Kussin, PS, and Samuelson, WM. "Cost-effectiveness of collecting routine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible lung tumor." Chest 109, no. 2 (February 1996): 451-456. Link to Item
  - Daniel, TL, Govert, JA, and Radtke, RA. "Physician practices in the diagnostic evaluation of suspected Obstructive Sleep Apnea (OSA)." Chest 110, no. 4 SUPPL. (1996): 202S-.
  - Daniel, TL, Govert, JA, and Radtke, RA. "Variation in physician threshold to treat Obstructive Sleep Apnea (OSA)." Chest 110, no. 4 SUPPL. (1996): 202S-.
  - Friedman, HS. "Treatment of acute myocardial infarction." N Engl J Med 329, no. 6 (August 5, 1993): 430-431. (Letter) Link to Item
  - Govert, JA, Patton, S, and Fine, RL. "Pancytopenia from using trimethoprim and methotrexate." Ann Intern Med 117, no. 10 (November 15, 1992): 877-878. (Letter) Link to Item
Teaching & Mentoring
Recent Courses
- MEDICINE 405C: Intensive Care Medicine Sub-Internship (Duke) 2017

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Journal Articles

Recent Courses