Scholars@Duke
Grace Jewel Kim

Grace Jewel Kim

Assistant Professor of Radiation Oncology
Radiation Oncology
DUMC Box 3085, Durham, NC 27710
Morris Bldg Radiation Oncology, Durham, NC 27710

Selected Publications

Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery.

Journal Article Advances in radiation oncology · March 2023 PurposeHypofractionated stereotactic radiosurgery (HF-SRS) with or without surgical resection is potentially a preferred treatment for larger or symptomatic brain metastases (BMs). Herein, we report clinical outcomes and predictive factors followi ... Full text Cite

Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: To examine the effectiveness and safety of single-isocenter multitarget stereotactic radiosurgery using a volume-adapted dosing strategy in patients with 4 to 10 brain metastases. METHODS AND MATERIALS: Adult patients with 4 to 10 brain metastases ... Full text Link to item Cite

Evaluation of Two Automated Treatment Planning Techniques for Multiple Brain Metastases Using A Single Isocenter

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2020 Cite

Treatment dilemma for survivors of rituximab-induced bowel perforation in the setting of post-transplant lymphoproliferative disorder.

Journal Article BMJ Case Rep · December 13, 2018 Post-transplant lymphoproliferative disorder (PTLD) is a recognised complication of solid and haematopoietic stem cell transplant. It consists of a heterogeneous group of lymphoid neoplasms that arises secondary to post-transplant immunosuppression. Althou ... Full text Link to item Cite

Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma.

Journal Article Anticancer Res · May 2018 BACKGROUND/AIM: Optimizing treatment of early-stage Hodgkin lymphoma (HL) requires balancing cure with potential acute and late toxicities from treatment. We reviewed our institutional experience with chemotherapy alone (ChT) versus combined modality thera ... Full text Link to item Cite

Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis.

Journal Article Neuro Oncol · October 1, 2017 BACKGROUND: Stereotactic radiosurgery (SRS) offers excellent local control for brain metastases (BM) with low rates of toxicity. Radiation necrosis (RN) may occur after treatment and is challenging to distinguish from local recurrence (LR). We evaluated en ... Full text Link to item Cite

Carcinoma of the esophagus

Chapter · May 10, 2017 Cite

Primary Non-Hodgkin's Lymphoma of the Gallbladder: A Population-based Analysis.

Journal Article Anticancer Res · May 2017 BACKGROUND/AIM: Primary Non-Hodgkin's lymphoma of the gallbladder (PNHL-GB) is extremely rare and data on clinical characteristics, optimal management and outcomes of these patients are limited to anecdotal reporting. We, therefore, sought to examine these ... Full text Link to item Cite

Leukemia and lymphoma

Journal Article Medical Radiology · January 1, 2017 Leukemias and lymphomas comprise a diverse collection of malignancies with unique clinical behavior. Radiation therapy plays an integral role in the definitive, adjuvant, and palliative management of these hematologic malignancies. As opposed to most epith ... Full text Cite

Single fraction stereotactic radiosurgery for multiple brain metastases.

Journal Article Adv Radiat Oncol · 2017 INTRODUCTION: Due to the neurocognitive side effects of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS) is being used with increasing frequency. The use of SRS is expanding for patients with multiple (>4) brain metastases (BM). This s ... Full text Open Access Link to item Cite

Single-Fraction Radiosurgery for 4 or More Brain Metastases.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 Full text Open Access Link to item Cite

Embracing rejection: Immunologic trends in brain metastasis.

Journal Article Oncoimmunology · July 2016 Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to t ... Full text Link to item Cite

The Benefit of Chemotherapy in Esophageal Cancer Patients With Residual Disease After Trimodality Therapy.

Journal Article Am J Clin Oncol · April 2016 INTRODUCTION: The objective of this retrospective study was to determine the potential benefits of chemotherapy in esophageal cancer patients treated with chemoradiation followed by surgery. MATERIALS AND METHODS: At our institution, 145 patients completed ... Full text Link to item Cite

Radiation therapy for gliomas

Chapter · March 31, 2016 Full text Cite

Physics considerations for single-isocenter, volumetric modulated arc radiosurgery for treatment of multiple intracranial targets.

Conference Pract Radiat Oncol · 2016 OBJECTIVE: Our purpose was to address challenges associated with single-isocenter radiosurgery for multiple intracranial targets (SIRMIT) including increased sensitivity to rotational uncertainties (resulting from distance of the targets from isocenter) as ... Full text Link to item Cite

Pathologic Evaluation of Radiographically Enlarging Lesions After Stereotactic Radiosurgery for Brain Metastases

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2015 PURPOSE: The German Hodgkin Study Group (GHSG) trial HD11 established 4 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and 30 Gy of radiation therapy (RT) as a standard for early stage (I, II), unfavorable Hodgkin lymphoma (HL). Addi ... Full text Link to item Cite

Modeling pathologic response of esophageal cancer to chemoradiation therapy using spatial-temporal 18F-FDG PET features, clinical parameters, and demographics.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2014 PURPOSE: To construct predictive models using comprehensive tumor features for the evaluation of tumor response to neoadjuvant chemoradiation therapy (CRT) in patients with esophageal cancer. METHODS AND MATERIALS: This study included 20 patients who under ... Full text Link to item Cite

Spatial-temporal [¹⁸F]FDG-PET features for predicting pathologic response of esophageal cancer to neoadjuvant chemoradiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2013 PURPOSE: To extract and study comprehensive spatial-temporal (18)F-labeled fluorodeoxyglucose ([(18)F]FDG) positron emission tomography (PET) features for the prediction of pathologic tumor response to neoadjuvant chemoradiation therapy (CRT) in esophageal ... Full text Link to item Cite

WE‐C‐BRA‐01: Best in Physics (Joint Imaging‐Therapy) ‐ Modeling Pathologic Response of Locally Advanced Esophageal Cancer to Chemoradiotherapy Using Spatial‐Temporal FDG‐PET Features, Clinical Parameters and Demographics

Conference Medical Physics · January 1, 2012 Purpose: To develop tumor response models using quantitative spatial‐temporal FDG‐PET features to accurately and precisely predict pathologic response to concurrent chemoradiotherapy (CRT) for locally advanced esophageal cancer patients. Methods: Data from ... Full text Cite

SU‐D‐BRC‐03: Spatial‐Temporal PET‐CT Features for Predicting Pathological Response of Esophagus Cancer to Chemo‐Radiation Therapies

Conference Medical Physics · January 1, 2011 Purpose: The purpose of this study is to develop new PET‐CT features for predicting the pathology response of esophagus tumor to chemo‐radiation therapies, and to compare their discriminant power with SUV‐max and SUV‐peak. Methods: Fifteen patients with lo ... Full text Cite

A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability.

Journal Article Cancer Res · November 1, 2006 Radiation-induced genomic instability (RIGI) manifests as a heritable increased rate of genetic alterations in the progeny of irradiated cells generations after the initial insult. The progeny can show an increased frequency of chromosomal translocations, ... Full text Link to item Cite

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.

Journal Article Mutagenesis · November 2006 Radiation-induced genomic instability (RIGI) challenges the long-standing notion that radiation's effects derive solely from nuclear impact. In RIGI it is the unirradiated progeny that can display phenotypic changes at delayed times after irradiation of th ... Full text Link to item Cite

Radiation-induced genomic instability: radiation quality and dose response.

Journal Article Health Phys · July 2003 Genomic instability is a term used to describe a phenomenon that results in the accumulation of multiple changes required to convert a stable genome of a normal cell to an unstable genome characteristic of a tumor. There has been considerable recent debate ... Full text Link to item Cite

A colony color method identifies the vulnerability of mitochondria to oxidative damage.

Journal Article Mutagenesis · September 2002 Mitochondrial dysfunction is a profound feature of cancer cells and is also known to cause several mitochondrial diseases. Mutations in mitochondrial DNA (mtDNA) have been reported frequently in these diseases. Although many environmental agents are known ... Full text Link to item Cite

Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin.

Journal Article Prostate · July 1, 2001 BACKGROUND: We previously demonstrated that the quinazoline-derived a1-adrenoceptor antagonists doxazosin and terazosin suppress prostate cancer growth via apoptosis induction. The aim of this study was to determine the potential effect of a1-adrenoceptor ... Full text Link to item Cite

Hippocampal dose from stereotactic radiosurgery for 4 to 10 brain metastases: Risk factors, feasibility of dose reduction via re-optimization, and patient outcomes.

Conference Med Dosim This study aimed to report hippocampal dose from single-fraction stereotactic radiosurgery (SRS) for 4 to 10 brain metastases and determine feasibility of hippocampal-sparing SRS. Patients with 4 to 10 brain metastases receiving single-isocenter, multi-tar ... Full text Link to item Cite