Carmelo Graffagnino
Professor of Neurology
As an neurointensivist with subspecialty training in cerebrovascular disease and neurocritical care my research focus is on the application of neurocritical care interventions to help patients with acute strokes and head injuries. My current research focuses both on improving and innovation of new therapies for patients with acute stroke as well as improving the systems of care that deliver life saving treatments to patients with stroke.
Current research studies include the use of neuroprotection strategies such as inhaled Nitric Oxide to protect the brain after removal of large vessel clots. I also involved in helping to develop and test new thrombolytic agents for use in acute stroke.
I am also working with a multidisciplinary team of systems of care experts at DCRI to re-engineer our stroke system of care across the heart of the Stroke Belt through a project called IMPROVE-Stroke Care which is leveraging novel informatics data systems to deliver state of the art care for patients with acute stroke.
I am also working with a number of colleagues in Neurology, Neurosurgery and Emergency medicine to apply the concept of system re-engineering to improve the outcomes of patients with acute traumatic brain injury in East Africa (Uganda, Kenya and Tanzania)
Current research studies include the use of neuroprotection strategies such as inhaled Nitric Oxide to protect the brain after removal of large vessel clots. I also involved in helping to develop and test new thrombolytic agents for use in acute stroke.
I am also working with a multidisciplinary team of systems of care experts at DCRI to re-engineer our stroke system of care across the heart of the Stroke Belt through a project called IMPROVE-Stroke Care which is leveraging novel informatics data systems to deliver state of the art care for patients with acute stroke.
I am also working with a number of colleagues in Neurology, Neurosurgery and Emergency medicine to apply the concept of system re-engineering to improve the outcomes of patients with acute traumatic brain injury in East Africa (Uganda, Kenya and Tanzania)
Current Appointments & Affiliations
- Professor of Neurology, Neurology, Neurocritical Care, Neurology 2013
Contact Information
- DUMC 3824, 0109 Orange Zone - South Clinics, Durham, NC 27710
- Duke Box 3824, 0109 Orange Zone - South Clinics, Durham, NC 27710
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(919) 684-3801
- Background
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Education, Training, & Certifications
- Stroke Fellow, Medicineq, University of Western Ontario (Canada) 1992
- Neurology Resident, Medicine, University of Western Ontario (Canada) 1988 - 1991
- Medical Resident, Medicine, University of Western Ontario (Canada) 1985 - 1988
- M.D., University of Western Ontario (Canada) 1985
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Duke Appointment History
- Professor of Medicine, Neurology, Clinical Science Departments 2011 - 2013
- Associate Professor of Medicine, Neurology, Clinical Science Departments 2006 - 2011
- Associate Clinical Professor of Medicine, Neurology, Clinical Science Departments 2004 - 2006
- Assistant Clinical Professor of Medicine, Neurology, Clinical Science Departments 2002 - 2004
- Assistant Professor of Medicine, Neurology, Clinical Science Departments 1994 - 2002
- Associate in the Department of Medicine, Neurology, Clinical Science Departments 1992 - 1994
- Recognition
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In the News
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MAY 24, 2016 Clinical Practice Today -
OCT 1, 2015
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- Expertise
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Global Scholarship
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Expertise
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Research
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Teaching
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- Research
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Selected Grants
- IMPROVE Stroke Care Systems of Care Research Program awarded by Daiichi Sankyo Inc 2018 - 2022
- Daiichi DS 1040 in Acute Ischemic Stroke awarded by Daiichi Sankyo Inc 2016 - 2019
- Secondary Stroke Prevention RE-SPECT ESUS awarded by Boehringer Ingelheim Pharmaceuticals, Inc. 2015 - 2019
- EDGE-2 awarded by Edge Therapeutics, Inc 2016 - 2019
- Medtronic Stroke Initiative awarded by Medtronic Foundation 2016 - 2019
- BMS- 986141 awarded by Bristol-Myers Squibb Company 2016 - 2017
- SOCRATES awarded by AstraZeneca Pharmaceuticals, LP 2013 - 2016
- Rivaroxaban in Reducing Post-Discharge Venous Thrombo-Embolism risk awarded by Janssen Research & Development, LLC 2014 - 2016
- TMS for Stroke Rehab awarded by Nexstim, Inc. 2014 - 2016
- EDGE SAH study awarded by Edge Therapeutics, Inc 2013 - 2016
- Transition of Care for Acute Stroke and Myocardial Infarction Patients awarded by Agency for Healthcare Research and Quality 2010 - 2011
- Aging And Cognition After Cardiac Surgery awarded by National Institutes of Health 1999 - 2004
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Savitz, SI, Yavagal, D, Rappard, G, Likosky, W, Rutledge, N, Graffagnino, C, Alderazi, Y, Elder, JA, Chen, PR, Budzik, RF, Tarrel, R, Huang, DY, and Hinson, JM. "A Phase 2 Randomized, Sham-Controlled Trial of Internal Carotid Artery Infusion of Autologous Bone Marrow-Derived ALD-401 Cells in Patients With Recent Stable Ischemic Stroke (RECOVER-Stroke)." Circulation 139, no. 2 (January 2019): 192-205. Full Text
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Lin, Chen, Ravi Vakani, Peter Kussin, Mary Guhwe, Alfredo E. Farjat, Kingshuk Choudhury, David Renner, Chrispine Oduor, Carmelo Graffagnino, and Carmelo Neuroscience Knowledge Base Investigator Group. “Assessment of healthcare personnel knowledge of stroke care at a large referral hospital in sub-Saharan Africa - A survey based approach..” Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 42 (August 2017): 71–74. https://doi.org/10.1016/j.jocn.2017.04.013.Full Text
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Olson, DaiWai M., Kyloni Phillips, and Carmelo Graffagnino. “Toward Solving the Sedation-Assessment Conundrum: Neurofunction Monitoring..” Critical Care Nursing Clinics of North America 28, no. 2 (June 2016): 205–16. https://doi.org/10.1016/j.cnc.2016.02.007.Full Text
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Babi, M. A., J. Dodds, L. F. Gonzales, A. Zomorodi, M In-Ping Huang Cobb, B. Brown, T. Smith, H. forrest, and C. Graffagnino. “Dual anti-platelet use following combination systemic tbrombolytics and endovascular reperfusion therapies does not increase risk of intracranial hemorrhage: experience from a large academic medical center.” Cerebrovascular Diseases 41 (January 1, 2016): 147–147.Link to Item
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Babi, M. A., J. Dodds, L. F. Gonzales, A. Zomorodi, M In-Ping Huang Cobb, P. Brown, T. Smith, H. Forrest, and C. Graffagnino. “Influence of age on clinical and revascularization outcomes on stroke endovascular reperfusion therapies: experience from a large academic medical center.” Cerebrovascular Diseases 41 (January 1, 2016): 149–149.Link to Item
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Bahl, M. A., I. Dodds, L. F. Gonzales, A. Zomorodi, M In-Ping Huang Cohh, P. Brown, T. Smith, H. Forresi, and C. Graffagnino. “General anesthesia for endovascular acute ischemic stroke treatment does not compromise good functional outcomes: experience from a large academic medical center.” Cerebrovascular Diseases 41 (January 1, 2016): 52–52.Link to Item
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Yavagal, D. R., D. Y. Huang, C. Graffagnino, G. Rappard, R. Budzik, W. Likosky, R. Tarrel, J. N. Rutledge, J. Hinson, and S. I. Savitz. “Intra-arterial delivery of autologous ALDHbr cells in ischemic stroke: final 1-year results of the recover-stroke trial.” International Journal of Stroke 10 (April 1, 2015): 13–13.Link to Item
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Graffagnino, Carmelo, David Erlinge, Thomas Keeble, and Graham Nichol. “Current advances in the use of therapeutic hypothermia..” Therapeutic Hypothermia and Temperature Management 5, no. 1 (March 2015): 9–12. https://doi.org/10.1089/ther.2015.1502.Full Text
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Lerner, David P., and Carmelo Graffagnino. “The disappearing thrombus: An uncommon cause of ischemic stroke..” Neurology. Clinical Practice 4, no. 6 (December 2014): 534–35. https://doi.org/10.1212/CPJ.0000000000000039.Full Text
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Polderman, Kees, Niklas Nielsen, Carmelo Graffagnino, and Marvin Wayne. “Therapeutic hypothermia in post-cardiac arrest..” Therapeutic Hypothermia and Temperature Management 4, no. 4 (December 2014): 154–58. https://doi.org/10.1089/ther.2014.1515.Full Text
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Olson, DaiWai M., Meg G. Zomorodi, Michael L. James, Christopher E. Cox, Eugene W. Moretti, Kristina E. Riemen, and Carmelo Graffagnino. “Exploring the impact of augmenting sedation assessment with physiologic monitors..” Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses 27, no. 3 (August 2014): 145–50. https://doi.org/10.1016/j.aucc.2013.09.001.Full Text
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McDonagh, David L., Miles Berger, Joseph P. Mathew, Carmelo Graffagnino, Carmelo A. Milano, and Mark F. Newman. “Neurological complications of cardiac surgery..” The Lancet. Neurology 13, no. 5 (May 2014): 490–502. https://doi.org/10.1016/S1474-4422(14)70004-3.Full Text
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Frank, Jeffrey I., L Philip Schumm, Kristen Wroblewski, Douglas Chyatte, Axel J. Rosengart, Christi Kordeck, Ronald A. Thisted, and Ronald A. HeADDFIRST Trialists. “Hemicraniectomy and durotomy upon deterioration from infarction-related swelling trial: randomized pilot clinical trial..” Stroke 45, no. 3 (March 2014): 781–87. https://doi.org/10.1161/STROKEAHA.113.003200.Full Text
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Gokhale, Sankalp, and Carmelo Graffagnino. “Hyperdense posterior cerebral artery sign in a setting of spontaneous vertebral artery dissection: a blessing in disguise?.” Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre 23, no. 1 (January 2014): 86–88. https://doi.org/10.1159/000351694.Full Text
- McDonagh, DL, Berger, M, Mathew, JP, Graffagnino, C, Milano, CA, and Newman, MF. "Neurological complications of cardiac surgery." The Lancet Neurology 13, no. 5 (January 1, 2014): 490-502. (Review) Full Text
- Olson, DWM, Zomorodi, MG, James, ML, Cox, CE, Moretti, EW, Riemen, KE, and Graffagnino, C. "Exploring the impact of augmenting sedation assessment with physiologic monitors." Australian Critical Care 27, no. 3 (January 1, 2014): 145-150. Full Text
- Gokhale, S, and Graffagnino, C. "Hyperdense posterior cerebral artery sign in a setting of spontaneous vertebral artery dissection: A blessing in disguise?." Medical Principles and Practice 23, no. 1 (December 1, 2013): 86-88. Full Text
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Olson, DaiWai M., Meg Zomorodi, Gavin W. Britz, Ali R. Zomorodi, Anthony Amato, and Carmelo Graffagnino. “Continuous cerebral spinal fluid drainage associated with complications in patients admitted with subarachnoid hemorrhage..” Journal of Neurosurgery 119, no. 4 (October 2013): 974–80. https://doi.org/10.3171/2013.6.jns122403.Full Text
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Bergese, S. D., C. Graffagnino, J. Love, D. Schneider, C. Lazardis, M. LaPointe, K. Lee, G. Lynch, M. Hu, and G. C. Williams. “The evAluation of patients with aCute hypertension and intraCerEbraL hEmorRhage with intrAvenous clevidipine TreatmEnt (ACCELERATE).” Cerebrovascular Diseases 35 (January 1, 2013): 685–685.Link to Item
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Graffagnino, Carmelo, Sergio Bergese, James Love, Dietmar Schneider, Christos Lazaridis, Marc LaPointe, Kiwon Lee, Gwendolyn Lynch, Ming-yi Hu, and Gregory C. Williams. “Clevidipine rapidly and safely reduces blood pressure in acute intracerebral hemorrhage: the ACCELERATE trial..” Cerebrovascular Diseases (Basel, Switzerland) 36, no. 3 (January 2013): 173–80. https://doi.org/10.1159/000351149.Full Text
- James, ML, Olson, DM, and Graffagnino, C. "A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury." Anaesthesia and Intensive Care 40, no. 6 (November 2012): 949-957. Full Text
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Ornato, Joseph P., Carmelo Graffagnino, Hans Friberg, Michael R. Mooney, and Eyal Herzog. “Therapeutic hypothermia in post-cardiac arrest..” Therapeutic Hypothermia and Temperature Management 2, no. 3 (September 2012): 109–11. https://doi.org/10.1089/ther.2012.1513.Full Text
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Prvu Bettger, Janet, Karen P. Alexander, Rowena J. Dolor, DaiWai M. Olson, Amy S. Kendrick, Liz Wing, Remy R. Coeytaux, Carmelo Graffagnino, and Pamela W. Duncan. “Transitional care after hospitalization for acute stroke or myocardial infarction: a systematic review..” Annals of Internal Medicine 157, no. 6 (September 2012): 407–16. https://doi.org/10.7326/0003-4819-157-6-201209180-00004.Full Text
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Graffagnino, Moderator Carmelo, Participants Eyal Herzog, Justin Lundbye, and Hans-Joerg Busch. “Therapeutic hypothermia and post-cardiac arrest..” Therapeutic Hypothermia and Temperature Management 2, no. 1 (March 2012): 6–9. https://doi.org/10.1089/ther.2012.1502.Full Text
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“Corrigendum.” Nursing in Critical Care 17, no. 1 (January 2012): 56–56. https://doi.org/10.1111/j.1478-5153.2011.00486.x.Full Text
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Olson, DaiWai M., Janet Prvu Bettger, Karen P. Alexander, Amy S. Kendrick, Julian R. Irvine, Liz Wing, Remy R. Coeytaux, Rowena J. Dolor, Pamela W. Duncan, and Carmelo Graffagnino. “Transition of care for acute stroke and myocardial infarction patients: from hospitalization to rehabilitation, recovery, and secondary prevention..” Evidence Report/Technology Assessment, no. 202 (October 2011): 1–197.
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Amato, Anthony, Gavin W. Britz, Michael L. James, Carmelo Graffagnino, Ali R. Zomorodi, Margaret E. Zomorodi, and DaiWai M. Olson. “An observational pilot study of CSF diversion in subarachnoid haemorrhage..” Nursing in Critical Care 16, no. 5 (September 2011): 252–60. https://doi.org/10.1111/j.1478-5153.2010.00444.x.Full Text
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Swaminathan, Madhav, Alina Nicoara, Barbara G. Phillips-Bute, Nicolas Aeschlimann, Carmelo A. Milano, G Burkhard Mackensen, Mihai V. Podgoreanu, et al. “Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery..” The Annals of Thoracic Surgery 91, no. 6 (June 2011): 1844–50. https://doi.org/10.1016/j.athoracsur.2011.02.008.Full Text
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Kim, G. S., A. Amato, M. L. James, G. W. Britz, A. Zomorodi, C. Graffagnino, M. Zomorodi, and DaiWai M. Olson. “Continuous and intermittent CSF diversion after subarachnoid hemorrhage: a pilot study..” Neurocritical Care 14, no. 1 (February 2011): 68–72. https://doi.org/10.1007/s12028-010-9401-y.Full Text
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Graffagnino, Carmelo, Ananda R. Gurram, Bradley Kolls, and DaiWai M. Olson. “Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes..” Neurocritical Care 13, no. 3 (December 2010): 307–12. https://doi.org/10.1007/s12028-010-9469-4.Full Text
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Snow, Richard, Joseph Ruane, Michelle LaLonde, Lynn Shaffer, Brett Kim, Cheryl Graffagnino, James Falko, Kathy Spencer, and Teresa Caulin-Glaser. “Randomized trial assessing the impact of a musculoskeletal intervention for pain before participating in a weight management program..” Journal of Cardiopulmonary Rehabilitation and Prevention 30, no. 3 (May 2010): 173–80. https://doi.org/10.1097/hcr.0b013e3181c565c8.Full Text
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Ionita, Catalina C., John Baker, Carmelo Graffagnino, Michael J. Alexander, Allan H. Friedman, and Osama O. Zaidat. “Timing of symptomatic vasospasm in aneurysmal subarachnoid hemorrhage: the effect of treatment modality and clinical implications..” Journal of Stroke and Cerebrovascular Diseases : The Official Journal of National Stroke Association 19, no. 2 (March 2010): 110–15. https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.11.009.Full Text
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Olson, DaiWai M., Suzanne M. Thoyre, Stacey N. Bennett, Joanna B. Stoner, and Carmelo Graffagnino. “Effect of mechanical chest percussion on intracranial pressure: a pilot study..” American Journal of Critical Care : An Official Publication, American Association of Critical Care Nurses 18, no. 4 (July 2009): 330–35. https://doi.org/10.4037/ajcc2009523.Full Text
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Zaidat, O. O., C. C. Ionita, S. I. Hussain, M. J. Alexander, A. H. Friedman, and C. Graffagnino. “Impact of ruptured cerebral aneurysm coiling and clipping on the incidence of cerebral vasospasm and clinical outcome..” Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging 19, no. 2 (April 2009): 144–49. https://doi.org/10.1111/j.1552-6569.2008.00285.x.Full Text
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Olson, Daiwai M., Suzanne M. Thoyre, Eric D. Peterson, and Carmelo Graffagnino. “A randomized evaluation of bispectral index-augmented sedation assessment in neurological patients..” Neurocritical Care 11, no. 1 (January 29, 2009): 20–27. https://doi.org/10.1007/s12028-008-9184-6.Full Text
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Aronow, Herbert D., Robert M. Califf, Robert A. Harrington, Marc Vallee, Carmelo Graffagnino, Ashfaq Shuaib, Desmond J. Fitzgerald, et al. “Relation between aspirin dose, all-cause mortality, and bleeding in patients with recent cerebrovascular or coronary ischemic events (from the BRAVO Trial)..” The American Journal of Cardiology 102, no. 10 (November 2008): 1285–90. https://doi.org/10.1016/j.amjcard.2008.07.019.Full Text
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Ionita, Catalina C., Carmelo Graffagnino, Michael J. Alexander, and Osama O. Zaidat. “The value of CT angiography and transcranial doppler sonography in triaging suspected cerebral vasospasm in SAH prior to endovascular therapy..” Neurocritical Care 9, no. 1 (January 2008): 8–12. https://doi.org/10.1007/s12028-007-9029-8.Full Text
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La Londe, Michelle, Richard Snow, Kathy Spencer, Cheryl Graffagnino, James M. Falko, and Teresa Caulin-Glaser. “Impact of participation level in a community weight loss program on determinants and prevalence of metabolic syndrome.” Circulation 115, no. 21 (May 29, 2007): E584–E584.Link to Item
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Bennett, Stacey S., Carmelo Graffagnino, Cecil O. Borel, and Michael L. James. “Use of high frequency oscillatory ventilation (HFOV) in neurocritical care patients..” Neurocritical Care 7, no. 3 (January 2007): 221–26. https://doi.org/10.1007/s12028-007-0084-y.Full Text
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Olson, DaiWai M., Suzanne M. Thoyre, Dennis A. Turner, Stacey Bennett, and Carmelo Graffagnino. “Changes in intracranial pressure associated with chest physiotherapy..” Neurocritical Care 6, no. 2 (January 2007): 100–103. https://doi.org/10.1007/s12028-007-0015-y.Full Text
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Olson, Daiwai, Mary Lynn, Suzanne M. Thoyre, and Carmelo Graffagnino. “The limited reliability of the Ramsay scale..” Neurocritical Care 7, no. 3 (January 2007): 227–31. https://doi.org/10.1007/s12028-007-0069-x.Full Text
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McGirt, Matthew J., Robert Blessing, Michael J. Alexander, Shahid M. Nimjee, Graeme F. Woodworth, Allan H. Friedman, Carmelo Graffagnino, Daniel T. Laskowitz, and John R. Lynch. “Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience..” Journal of Neurosurgery 105, no. 5 (November 2006): 671–74. https://doi.org/10.3171/jns.2006.105.5.671.Full Text
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Bushnell, Cheryl D., Jeffrey Griffin, L Kristin Newby, Larry B. Goldstein, Kenneth W. Mahaffey, Carmelo A. Graffagnino, Robert A. Harrington, et al. “Statin use and sex-specific stroke outcomes in patients with vascular disease..” Stroke 37, no. 6 (June 2006): 1427–31. https://doi.org/10.1161/01.str.0000221315.60282.ca.Full Text
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Graffagnino, Cheryl L., James M. Falko, Michelle La Londe, Joann Schaumburg, Michael F. Hyek, Lynn E. T. Shaffer, Richard Snow, and Teresa Caulin-Glaser. “Effect of a community-based weight management program on weight loss and cardiovascular disease risk factors..” Obesity (Silver Spring, Md.) 14, no. 2 (February 2006): 280–88. https://doi.org/10.1038/oby.2006.36.Full Text
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Olson, DaiWai M., and Carmelo Graffagnino. “Consciousness, coma, and caring for the brain-injured patient..” Aacn Clinical Issues 16, no. 4 (October 2005): 441–55. https://doi.org/10.1097/00044067-200510000-00003.Full Text
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Lynch, John R., Haichen Wang, Matthew J. McGirt, James Floyd, Allan H. Friedman, Alexander L. Coon, Robert Blessing, et al. “Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial..” Stroke 36, no. 9 (September 2005): 2024–26. https://doi.org/10.1161/01.str.0000177879.11607.10.Full Text
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Olson, Daiwai M., Carmelo Graffagnino, Kenneth King, and John R. Lynch. “Toward solving the sedation-assessment conundrum: bi-spectral index monitoring and sedation interruption..” Critical Care Nursing Clinics of North America 17, no. 3 (September 2005): 257–67. https://doi.org/10.1016/j.ccell.2005.04.008.Full Text
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Zaidat, Osama O., Andy P. Slivka, Yousef Mohammad, Carmelo Graffagnino, Tony P. Smith, David S. Enterline, Greg A. Christoforidis, Michael J. Alexander, Dennis M. D. Landis, and Jose I. Suarez. “Intra-arterial thrombolytic therapy in peri-coronary angiography ischemic stroke..” Stroke 36, no. 5 (May 2005): 1089–90. https://doi.org/10.1161/01.str.0000162392.44326.ec.Full Text
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Ionita, Catalina C., Joseph Ferrara, David L. McDonagh, Peter Grossi, and Carmelo Graffagnino. “Systemic hemostasis with recombinant-activated factor VII followed by local thrombolysis with recombinant tissue plasminogen activator in intraventricular hemorrhage..” Neurocritical Care 3, no. 3 (January 2005): 246–48. https://doi.org/10.1385/ncc:3:3:246.Full Text
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Kassem-Moussa, Hassan, Kenneth W. Mahaffey, Carmelo Graffagnino, Gudaye Tasissa, Cathy A. Sila, R John Simes, Harvey D. White, et al. “Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome..” American Heart Journal 148, no. 3 (September 2004): 439–46. https://doi.org/10.1016/j.ahj.2004.01.028.Full Text
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Al-Senani, Fahmi M., Carmelo Graffagnino, James C. Grotta, Robin Saiki, Denise Wood, William Chung, Grant Palmer, and Ken A. Collins. “A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest..” Resuscitation 62, no. 2 (August 2004): 143–50. https://doi.org/10.1016/j.resuscitation.2004.02.016.Full Text
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Topol, Eric J., Donald Easton, Robert A. Harrington, Pierre Amarenco, Robert M. Califf, Carmen Graffagnino, Stephen Davis, et al. “Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease..” Circulation 108, no. 4 (July 21, 2003): 399–406. https://doi.org/10.1161/01.cir.0000084501.48570.f6.Full Text
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McCarron, M. O., C. J. Weir, K. W. Muir, K. L. Hoffmann, C. Graffagnino, J. A. R. Nicoll, K. R. Lees, and M. J. Alberts. “Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage..” Acta Neurologica Scandinavica 107, no. 2 (February 2003): 106–9. https://doi.org/10.1034/j.1600-0404.2003.01365.x.Full Text
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Kassem-Moussa, Hassan, and Carmelo Graffagnino. “Nonocclusion and spontaneous recanalization rates in acute ischemic stroke: a review of cerebral angiography studies..” Archives of Neurology 59, no. 12 (December 2002): 1870–73. https://doi.org/10.1001/archneur.59.12.1870.Full Text
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Al-Senani, F. M., R. Saiki, W. B. Chung, E. A. Ryba, T. Bleck, H. Kassem-Moussa, D. Wood, and C. Graffagnino. “A prospective, multicenter pilot study to evaluate the feasibility and safety of using the COOLGARD system and icy catheter after cardiac arrest.” Annals of Neurology 52, no. 3 (September 1, 2002): S60–S60.Link to Item
- Bulsara, KR, Alexander, MJ, Villavicencio, AT, and Graffagnino, C. "De novo cerebral arteriovenous malformation: case report." Neurosurgery 50, no. 5 (May 2002): 1137-1140. Full Text
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Schwab, S., D. Georgiadis, P. D. Schellinger, J. Berrouschot, C. Graffagnino, and S. A. Mayer. “Re: Feasibility and safety of moderate hypothermia after massive hemispheric infarction - Response.” Stroke 33, no. 3 (March 1, 2002): 877–78.Link to Item
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Alberts, M. J., M. O. McCarron, K. L. Hoffmann, and C. Graffagnino. “Familial clustering of intracerebral hemorrhage: a prospective study in North Carolina..” Neuroepidemiology 21, no. 1 (January 2002): 18–21. https://doi.org/10.1159/000048609.Full Text
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Schwab, S., D. Georgiadis, J. Berrouschot, P. D. Schellinger, C. Graffagnino, and S. A. Mayer. “Feasibility and safety of moderate hypothermia after massive hemispheric infarction..” Stroke 32, no. 9 (September 2001): 2033–35. https://doi.org/10.1161/hs0901.095394.Full Text
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Harrington, R. A., P. W. Armstrong, C. Graffagnino, F. Van De Werf, D. J. Kereiakes, K. N. Sigmon, T. Card, et al. “Dose-finding, safety, and tolerability study of an oral platelet glycoprotein IIb/IIIa inhibitor, lotrafiban, in patients with coronary or cerebral atherosclerotic disease..” Circulation 102, no. 7 (August 2000): 728–35. https://doi.org/10.1161/01.cir.102.7.728.Full Text
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Topol, E. J., J. D. Easton, P. Amarenco, R. Califf, R. Harrington, C. Graffagnino, S. Davis, et al. “Design of the blockade of the glycoprotein IIb/IIIa receptor to avoid vascular occlusion (BRAVO) trial..” American Heart Journal 139, no. 6 (June 2000): 927–33. https://doi.org/10.1067/mhj.2000.105107.Full Text
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McCarron, M. O., M. J. Alberts, K. L. Hoffmann, and C. Graffagnino. “Familial clustering of intracerebral hemorrhage.” Neurology 54, no. 7 (April 11, 2000): A262–63.Link to Item
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Abciximab in Ischemic Stroke Investigators, K. M. “Abciximab in acute ischemic stroke. A randomized, double-blind, placebo-controlled, dose-escalation study..” Stroke 31, no. 3 (March 2000): 601–9. https://doi.org/10.1161/01.str.31.3.601.Full Text
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Mahaffey, K. W., R. A. Harrington, M. L. Simoons, C. B. Granger, C. Graffagnino, M. J. Alberts, D. T. Laskowitz, et al. “Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators..” Circulation 99, no. 18 (May 1999): 2371–77. https://doi.org/10.1161/01.cir.99.18.2371.Full Text
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Graffagnino, C., C. R. Gomez, S. A. Mayer, G. L. Bernardini, and M. D. Malkoff. “Induced controlled extended hypothermia improves outcomes in malignant stroke.” Neurology 50, no. 4 (April 1, 1998): A412–13.Link to Item
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Mahaffey, K. “Comparison of Stroke Rates in Patients With Acute Coronary Syndromes and Patients With Acute Myocardial Infarction.” Journal of the American College of Cardiology 31, no. 2 (February 1998): 406A-406A. https://doi.org/10.1016/s0735-1097(97)85468-x.Full Text
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Albers, M. J., S. E. Moore, K. L. Hoffmann, D. M. Delong, C. Graffagnino, C. Granger, and A. M. Saunders. “Genetic studies of intracerebral hemorrhage.” Stroke 29, no. 1 (January 1, 1998): 320–320.Link to Item
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Alberts, M. J., J. P. Davis, C. Graffagnino, C. McClenny, D. Delong, C. Granger, M. H. Herbstreith, K. Boteva, D. A. Marchuk, and A. D. Roses. “Endoglin gene polymorphism as a risk factor for sporadic intracerebral hemorrhage..” Annals of Neurology 41, no. 5 (May 1997): 683–86. https://doi.org/10.1002/ana.410410519.Full Text
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Chu, C. T., L. G. Leithe, C. Graffagnino, L. B. Goldstein, and C. M. Hulette. “Diagnosis of intracranial vasculitis: A multidisciplinary approach..” Journal of Neuropathology and Experimental Neurology 56, no. 5 (May 1, 1997): 120–120.Link to Item
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Gasecki, A. P., C. Graffagnino, and V. Hachinski. “Tissue plasminogen activator in a vertebral artery dissection..” The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques 24, no. 2 (May 1997): 151–54.
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Alberts, M. J., J. P. Davis, C. Graffagnino, C. McClenny, D. Delong, M. H. Herbstreith, C. Granger, K. Boteva, D. A. Marchuk, and A. D. Roses. “Polymorphism in endoglin as a risk factor for intracerebral hemorrhage.” Stroke 28, no. 1 (January 1, 1997): 69–69.Link to Item
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Hachinski, V., C. Graffagnino, M. Beaudry, G. Bernier, C. Buck, A. Donner, J. D. Spence, G. Doig, and B. M. Wolfe. “Lipids and stroke: a paradox resolved..” Archives of Neurology 53, no. 4 (April 1996): 303–8. https://doi.org/10.1001/archneur.1996.00550040031011.Full Text
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Alberts, M. J., C. Graffagnino, C. McClenny, D. DeLong, W. J. Strittmatter, A. M. Saunders, and A. D. Roses. “Effect of ApoE genotype and age on survival after intracerebral hemorrhage.” Stroke 27, no. 1 (January 1, 1996): 94–94.Link to Item
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Graffagnino, C., M. H. Herbstreith, D. E. Schmechel, E. Levy, A. D. Roses, and M. J. Alberts. “Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage..” Stroke 26, no. 11 (November 1995): 2190–93. https://doi.org/10.1161/01.str.26.11.2190.Full Text
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Alberts, M. J., C. Graffagnino, C. McClenny, D. DeLong, W. Strittmatter, A. M. Saunders, and A. D. Roses. “ApoE genotype and survival from intracerebral haemorrhage..” Lancet (London, England) 346, no. 8974 (August 1995). https://doi.org/10.1016/s0140-6736(95)91411-0.Full Text
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Alberts, M. J., A. Quinones, C. Graffagnino, A. Friedman, and A. D. Roses. “Risk of intracranial aneurysms in families with subarachnoid hemorrhage..” The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques 22, no. 2 (May 1995): 121–25.
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GRAFFAGNINO, C. “Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage.” Stroke 26 (1995): 2190–93.
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Graffagnino, C., M. H. Herbstreith, A. D. Roses, and M. J. Alberts. “A molecular genetic study of intracerebral hemorrhage..” Archives of Neurology 51, no. 10 (October 1994): 981–84. https://doi.org/10.1001/archneur.1994.00540220027011.Full Text
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Graffagnino, C., A. P. Gasecki, G. S. Doig, and V. C. Hachinski. “The importance of family history in cerebrovascular disease..” Stroke 25, no. 8 (August 1994): 1599–1604. https://doi.org/10.1161/01.str.25.8.1599.Full Text
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ALBERTS, M. J., M. C. SPEER, A. QUINONES, C. GRAFFAGNINO, A. FRIEDMAN, and A. D. ROSES. “RISK OF INTRACRANIAL ANEURYSMS IN FAMILIES WITH SUBARACHNOID HEMORRHAGE.” Stroke 25, no. 1 (January 1, 1994): 248–248.Link to Item
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GRAFFAGNINO, C. “The importance of family history in cerebrovascular disease.” Stroke 25 (1994): 1599–1604.
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GRAFFAGNINO, C., J. MAHER, A. QUINONES, V. C. HACHINSKI, A. FRIEDMAN, G. C. EBERS, G. G. FERGUSON, C. G. DRAKE, A. D. ROSES, and M. J. ALBERTS. “GENETIC-ASPECTS OF INTRACRANIAL ANEURYSMS AND SAH.” Stroke 25, no. 1 (January 1, 1994): 257–257.Link to Item
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Graffagnino, C., and M. J. Alberts. “Restriction fragment length polymorphism of the apoprotein A-I-C-III gene cluster in control and stroke-prone white and black subjects: racial differences..” Stroke 24, no. 6 (June 1993): 909–10. https://doi.org/10.1161/01.str.24.6.909.Full Text
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Alberts, M. J., and C. Graffagnino. “Ulcerated plaques in the aortic arch in patients with stroke..” The New England Journal of Medicine 327, no. 2 (July 1992): 128–29. https://doi.org/10.1056/nejm199207093270215.Full Text
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Book Sections
- Guhwe, M, Blessing, K, Chioffi, S, and Graffagnino, C. "Medical management of a stroke." In Emergency Approaches to Neurosurgical Conditions, 137-149. January 1, 2015. Full Text
- "Hypothermia: Physiology and applications." In Neurocritical Care, 38-48. January 1, 2009. Full Text
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Other Articles
- Mackensen, GB, Ti, LK, Phillips-Bute, BG, Mathew, JP, Newman, MF, Grocott, HP, and Neurologic Outcome Research Group (NORG), . "Cerebral embolization during cardiac surgery: impact of aortic atheroma burden." British Journal of Anaesthesia 91, no. 5 (November 2003): 656-661. Full Text
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Swaminathan, Madhav, Brian J. McCreath, Barbara G. Phillips-Bute, Mark F. Newman, Joseph P. Mathew, Peter K. Smith, James A. Blumenthal, Mark Stafford-Smith, and Mark Perioperative Outcomes Research Group. “Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction..” Anesthesia and Analgesia, July 2002. https://doi.org/10.1097/00000539-200207000-00001.Full Text
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Grigore, Alina M., Hilary P. Grocott, Joseph P. Mathew, Barbara Phillips-Bute, Timothy O. Stanley, Aimee Butler, Kevin P. Landolfo, et al. “The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery..” Anesthesia and Analgesia, January 2002. https://doi.org/10.1097/00000539-200201000-00002.Full Text
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Conference Papers
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Bergese, S. D., C. Graffagnino, J. Love, D. Schneider, M. LaPointe, C. Lazaridis, K. Lee, and G. Lynch. “Clevidipine rapidly and safely reduces blood pressure in acute intracerebral haemorrhage; The ACCELERATE trial cover title: clevidipine rapidly and safely reduces BP in ICH.” In European Journal of Neurology, 19:50–50. WILEY-BLACKWELL, 2012.Link to Item
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Graffagnino, Carmelo, Sergio Bergese, James Love, Dietmar Schneider, Christos Lazaridis, Marc LaPointe, Kiwon Lee, and Gwendolyn Lynch. “Aggressive Blood Pressure Control with Clevidipine in Patients with Acute Intracerebral Hemorrhage is Rapid and Well Tolerated: The ACCELERATE Trial.” In Stroke, 42:E218–E218. LIPPINCOTT WILLIAMS & WILKINS, 2011.Link to Item
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James, Michael, Gavin Britz, Carmelo Graffagnino, Margaret Zomorodi, Ali Zomorodi, and DaiWai Olson. “VENTRICULOSTOMY AND CSF DRAINAGE IN SAH.” In Critical Care Medicine, 37:A167–A167. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Ionita, C. C., O. Zaidat, D. Laskowitz, J. R. Lynch, V. R. Chilukuri, M. J. Alexander, A. Friedman, and C. Graffagnino. “Correlation between Transcranial Doppler Sonography and CT angiography in detecting vasospasm in aneurysmal subarachnoid hemorrhage.” In Neurology, 64:A404–A404. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Ionita, C. C., O. Zaidat, J. Floyd, M. J. Alexander, A. Friedman, J. R. Lynch, D. Laskowitz, V. R. Chilukuri, and C. Graffagnino. “Incidence of vasospasm in aneurysmal subarachnoid hemorrhage; Surgical clipping versus endovascular coiling.” In Neurology, 64:A404–5. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Zaidat, O. O., C. Ionita, M. Tolbert, C. Graffagnino, and M. J. Alexander. “Endovascular cerebral aneurysm coil embolization using polymer coated (Matrix (TM)) detachable coils: Preliminary single center experience of 181 aneurysms.” In Neurology, 64:A301–A301. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Zadat, O. O., Y. Mohammad, M. J. Alexander, C. Graffagnino, C. Ionita, G. A. Christoforidis, A. P. Slivka, and J. I. Suarez. “Intraarterial thrombolytic therapy in the postcoronary angiography stroke.” In Stroke, 36:451–451, 2005.Link to Item
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Zaidat, O. O., Y. Mohammad, M. J. Alexander, C. Graffagnino, C. Ionita, G. A. Christoforidis, A. P. Slivka, and J. I. Suarez. “Intraarterial thrombolytic therapy in the postcoronary angiography stroke.” In Stroke, 36:451–451. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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LaLonde, M., C. Graffagnino, J. Schaumburg, T. Caulin-Glaser, M. Hyek, and R. Snow. “Differences in body weight, BMI, lipid profile and fasting blood glucose in individuals repeating a structured 6-month weight management program.” In Obesity Research, 12:A53–A53. NORTH AMER ASSOC STUDY OBESITY, 2004.Link to Item
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Aronow, H. D., R. M. Califf, R. A. Harrington, M. Vallee, C. Graffagnino, A. Shuaib, D. Fitzgerald, et al. “Higher aspirin dose is associated with reduced mortality and more serious bleeding in patients with recent cerebrovascular or coronary ischemic events: Insights from the BRAVO trial.” In Circulation, 108:680–81. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Graffagnino, C. “Fever control in neurointensive care unit patients using a novel catheter-based heat exchange system.” In Intensive Care Medicine, 28:S192–S192. SPRINGER-VERLAG, 2002.Link to Item
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