Augustus Oliver Grant | Scholars@Duke

Augustus Oliver Grant
Professor of Medicine

This laboratory seeks to understand the molecular events that control excitation in cardiac muscle and the mechanisms by which excitation is modified by drugs. The experimental models include the isolated cardiac myocyte, the frog oocyte and mammalian cells expressing mRNA transcripts of wild-type and mutant channels. The experimental techniques include DNA and RNA manipulation, whole cell voltage clamping and the extracellular patch clamping. The current focus of the laboratory is the voltage gated sodium channel. The problems under study include:

1) The functional effects of the derangements occurring during
myocardial ischemia on channel function.
2) The mechanisms of blockade of channels by antiarrhythmic drugs.
3) The relationship between channel structure and antiarrhythmic drug
binding.
4) The development of models to describe the interaction of anti-
arrhythmic drugs with membrane channels.

These studies should provide a clearer understanding of the cellular basis of cardiac arrhythmias and the mechanisms by which they are terminated by drug.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Cardiology, Medicine 2000
Vice Dean, for Faculty Enrichment, Medicine, Clinical Science Departments 2007

Contact Information

2301 Erwin Road, 7th Floor, Room #7407, Durham, NC 27710
Duke Box 3504, Durham, NC 27710
grant007@mc.duke.edu (919) 684-3901

Background
Education, Training, & Certifications
- Ph.D., University of California at Los Angeles 1975
- M.B.B.Ch., University of Edinburgh (Scotland) 1971
Duke Appointment History
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 1990 - 2000
- Assistant Professor of Medicine, Medicine, Clinical Science Departments 1980 - 1986
Research
Selected Grants
- Mechanisms Regulating Gastrointestinal Hormone Secretion awarded by National Institutes of Health 2011 - 2016
- Tissue-engineered Autonomous Pacemaker awarded by National Institutes of Health 2011 - 2014
- Ryanodine Receptors in Bronchoconstriction awarded by National Institutes of Health 2007 - 2012
- Inherited Ion Channel Defects and Their Modulation in Ar awarded by National Institutes of Health 2001 - 2006
- Heart Failure Specialized Center Of Research awarded by National Institutes of Health 1995 - 1999
- Pharmacology Of Unitary Conductances In Cardiac Muscle awarded by National Institutes of Health 1984 - 1999
- Electrophysiologic Responses To Ion Channel Blockade awarded by National Institutes of Health 1993 - 1997
- Pharmacology Of Unitary Conductances In Cardiac Muscle awarded by National Institutes of Health 1993 - 1994
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Black-Maier, E, Ren, X, Steinberg, BA, Green, CL, Barnett, AS, Rosa, NS, Al-Khatib, SM, Atwater, BD, Daubert, JP, Frazier-Mills, C, Grant, AO, Hegland, DD, Jackson, KP, Jackson, LR, Koontz, JI, Lewis, RK, Sun, AY, Thomas, KL, Bahnson, TD, and Piccini, JP. "Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction." Heart Rhythm 15, no. 5 (May 2018): 651-657. Full Text
  - Black-Maier, EW, Pokorney, SD, Barnett, AS, Liu, P, Shrader, P, Ng, J, Goldberger, JJ, Zareba, W, Daubert, JP, Grant, AO, and Piccini, JP. "Ranolazine reduces atrial fibrillatory wave frequency." Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 19, no. 7 (July 2017): 1096-1100. Full Text
  - Daubert, JP, Grant, AO, and Jr, KRN. "Novel insights into beta-blocker therapy for long QT syndromes." Journal of the American College of Cardiology 60, no. 20 (2012): 2100-2101. Full Text
  - Wang, Y, Chandra, R, Samsa, LA, Gooch, B, Fee, BE, Cook, JM, Vigna, SR, Grant, AO, and Liddle, RA. "Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor." American Journal of Physiology. Gastrointestinal and Liver Physiology 300, no. 4 (April 2011): G528-G537. Full Text
  - Grant, AO. "Basic Electrophysiology." Cardiac Electrophysiology Clinics 2, no. 3 (2010): 325-340. Full Text
  - Grant, AO. "Cardiac ion channels." Circulation. Arrhythmia and Electrophysiology 2, no. 2 (April 2009): 185-194. (Review) Full Text
  - Grant, AO. "The variability of the electrical properties of the pulmonary veins." Journal of Cardiovascular Electrophysiology 20, no. 9 (2009): 1046-1047. Full Text
  - Nilsson, KR, Sewell, PM, Blunden-Kasdorf, P, Starkey, K, Grant, AO, and Wagner, GS. "The influence of cardiograph design and automated algorithms on the incidence and detection of electrode cable reversals in an academic electrocardiogram laboratory." J Electrocardiol 41, no. 5 (September 2008): 382-387. Full Text Link to Item
  - Thomas, K, and Grant, AO. "Ethnicity and arrhythmia susceptibility." Journal of Cardiovascular Electrophysiology 19, no. 4 (2008): 427-429. Full Text
  - Lehnart, SE, Ackerman, MJ, Benson, DW, Brugada, R, Clancy, CE, Donahue, JK, George, AL, Grant, AO, Groft, SC, January, CT, Lathrop, DA, Lederer, WJ, Makielski, JC, Mohler, PJ, Moss, A, Nerbonne, JM, Olson, TM, Przywara, DA, Towbin, JA, Wang, L-H, and Marks, AR. "Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function." Circulation 116, no. 20 (November 2007): 2325-2345. Full Text
  - Mensah, GA, Grant, AO, Pepine, CJ, Baddour, LM, Cooper, LT, Dunbar, SB, Froelicher, ES, Greenlund, KJ, Kaplan, EL, Kloner, RA, Labarthe, DR, Luepker, RV, Madjid, M, Muller, JE, O'Connor, S, Ornato, JP, Robertson, RM, Roy, MJ, Shah, PK, Taubert, KA, Wilson, WR, Zheng, Z-J, Harrington, RA, Abrams, J, Anderson, JL, Bates, ER, Eisenberg, MJ, Grines, CL, Hlatky, MA, Lichtenberg, RC, Lindner, JR, Pohost, GM, Schofield, RS, Shubrooks, SJ, Stein, JH, Tracy, CM, Vogel, RA, and Wesley, DJ. "ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases." Circulation 115, no. 12 (March 19, 2007): 1656-1695. Full Text
  - Grant, AO, and Tranquillo, J. "Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation." Journal of Cardiovascular Electrophysiology 18, no. 2 (February 2007): 204-205. Full Text
  - Mensah, GA, Grant, AO, Pepine, CJ, Baddour, LM, Jr, LTC, Dunbar, SB, Froelicher, ES, Greenlund, KJ, Kaplan, EL, Kloner, RA, Labarthe, DR, Luepker, RV, Madjid, M, Muller, JE, O'Connor, S, Ornato, JP, Robertson, RM, Roy, MJ, Shah, PK, Taubert, KA, Wilson, WR, Zheng, Z-J, Harrington, RA, Abrams, J, Anderson, JL, Bates, ER, Eisenberg, MJ, Grines, CL, Hlatky, MA, Lichtenberg, RC, Lindner, JR, Pohost, GM, Schofield, RS, Jr, SJS, Stein, JH, Tracy, CM, Vogel, RA, and Wesley, DJ. "ACCF/AHA/CDC Conference Report on Emerging Infectious Diseases and Biological Terrorism Threats^**The findings and conclusions in this report are those of the Conference participants and do not necessarily reflect the official position of the American College of Cardiology Foundation, the American Heart Association, and the Centers for Disease Control and Prevention." Journal of the American College of Cardiology 49, no. 12 (2007): 1373-1375. Full Text
  - Mensah, GA, Grant, AO, and Pepine, CJ. "ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats. The clinical and public health implications for the prevention and control of cardiovascular diseases." Circulation 115, no. 12 (2007): 1659-1662. Full Text
  - Mensah, GA, Grant, AO, and Pepine, CJ. "ACCF/AHA/CDC Conference Report on Emerging Infectious Diseases and Biological Terrorism Threats." Journal of the American College of Cardiology 49, no. 12 (2007): 1376-1379. Full Text
  - Zhang, Z-S, Tranquillo, J, Neplioueva, V, Bursac, N, and Grant, AO. "Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease." American Journal of Physiology. Heart and Circulatory Physiology 292, no. 1 (January 2007): H399-H407. Full Text
  - Grant, AO. "Critical reviews in basic electrophysiology: Realizing the synergy between the basic and clinical sciences." Journal of Cardiovascular Electrophysiology 17, no. 2 (2006): 219--. Full Text
  - Ross, JS, Gross, CP, Desai, MM, Hong, Y, Grant, AO, Daniels, SR, Hachinski, VC, Gibbons, RJ, Gardner, TJ, and Krumholz, HM. "Effect of blinded peer review on abstract acceptance." Journal of the American Medical Association 295, no. 14 (2006): 1675-1680. Full Text
  - "Correction." Journal of the American College of Cardiology 46, no. 11 (December 2005): 2151-2152. Full Text
  - Carboni, M, Zhang, Z-S, Neplioueva, V, Starmer, CF, and Grant, AO. "Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue." J Membr Biol 207, no. 2 (September 2005): 107-117. Full Text Link to Item
  - Grant, AO. "Electrophysiological basis and genetics of Brugada syndrome." J Cardiovasc Electrophysiol 16 Suppl 1 (September 2005): S3-S7. (Review) Full Text Link to Item
  - Bonow, RO, Grant, AO, and Jacobs, AK. "The cardiovascular state of the union: Confronting healthcare disparities." Circulation 111, no. 10 (2005): 1205-1207. Full Text
  - Zipes, DP, Ackerman, MJ, III, NAME, Grant, AO, Myerburg, RJ, and Hare, GV. "Task force 7: Arrhythmias." Journal of the American College of Cardiology 45, no. 8 (2005): 1354-1363. Full Text
  - Bahnson, TD, and Grant, AO. "To be or not to be in normal sinus rhythm: what do we really know?." Ann Intern Med 141, no. 9 (November 2, 2004): 727-729. Link to Item
  - Bonow, RO, Zipes, DP, Anderson, JL, Cheitlin, MD, Goldstein, LB, Grant, AO, Faxon, D, Lima, JAC, and Robertson, RM. "Task force 5: Expert testimony and opinions." J Am Coll Cardiol 44, no. 8 (October 19, 2004): 1747-1749. (Review) Full Text Link to Item
  - Popp, RJ, Smith, SC, Adams, RJ, Antman, EM, Kavey, REW, DeMaria, AN, Ohman, EM, Pitt, B, Willerson, JT, Bellande, BJ, Fonarow, GC, Nishimura, RA, Shah, PM, Hirshfeld, JW, Messer, JV, Peterson, ED, Prystowsky, EN, Anderson, JL, Cheitlin, MD, Goldstein, LB, Grant, AO, Beller, GA, Hines, EF, Livingston, DW, McEntree, CW, American College of Cardiology Foundation, , and American Heart Association, . "ACCF/AHA consensus conference report on professionalism and ethics." Circulation 110, no. 16 (October 2004): 2506-2549. (Review) Full Text
  - Liu, L, Zhu, W, Zhang, ZS, Yang, T, Grant, A, Oxford, G, and Simon, SA. "Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors." Journal of Neurophysiology 91, no. 4 (April 2004): 1482-1491. Full Text
  - Grant, AO, Jacobs, AK, and Clancy, C. "Cardiovascular disease in women: are there solutions?." Circulation 109, no. 5 (February 10, 2004): 561-. Full Text Link to Item
  - Anderson, JL, Cheitlin, MD, Goldstein, LB, and Grant, AO. "Task force 5: Expert testimony and opinions." Circulation 110, no. 16 (2004): 2535-2537.
  - Grant, AO, and Jacobs, AK. "The benefit of prevention: engaging the public through strategic collaborations." Circulation 109, no. 25 (2004): 3062-6063.
  - Grant, AO. "Recent advances in the treatment of arrhythmias." Circ J 67, no. 8 (August 2003): 651-655. (Review) Link to Item
  - Starmer, CF, Grant, AO, and Colatsky, TJ. "What happens when cardiac Na channel function is compromised? 2. Numerical studies of the vulnerable period in tissue altered by drugs." Cardiovasc Res 57, no. 4 (March 15, 2003): 1062-1071. Link to Item
  - Starmer, CF, Colatsky, TJ, and Grant, AO. "What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels." Cardiovasc Res 57, no. 1 (January 2003): 82-91. Link to Item
  - Grant, AO, Carboni, MP, Neplioueva, V, Starmer, CF, Memmi, M, Napolitano, C, and Priori, S. "Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation." The Journal of Clinical Investigation 110, no. 8 (October 2002): 1201-1209. Full Text
  - Grant, AO. "Molecular biology of sodium channels and their role in cardiac arrhythmias." Am J Med 110, no. 4 (March 2001): 296-305. (Review) Link to Item
  - Link, MS, Antzelevitch, C, Waldo, AL, Grant, AO, DiMarco, JP, Josephson, ME, Marchlinski, FE, Garan, H, Sager, PT, Reynolds, DW, Denes, P, Scheinman, MM, and III, NAME. "Clinical cardiac electrophysiology fellowship teaching objectives for the new millennium." Journal of Cardiovascular Electrophysiology 12, no. 12 (2001): 1433-1443.
  - Grant, AO, Chandra, R, Keller, C, Carboni, M, and Starmer, CF. "Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells." Biophys J 79, no. 6 (December 2000): 3019-3035. Full Text Link to Item
  - Chauhan, VS, Tuvia, S, Buhusi, M, Bennett, V, and Grant, AO. "Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice." Circ Res 86, no. 4 (March 3, 2000): 441-447. Link to Item
  - Grant, AO. "Pro arrhythmia: Classification, incidence, risk factors, monitoring, prevention and management." Cardiac Electrophysiology Review 4, no. 3-4 (2000): 206-211.
  - Chandra, R, Chauhan, VS, Starmer, CF, and Grant, AO. "β-Adrenergic action on wild-type and KPQ mutant human cardiac Na⁺ channels: Shift in gating but no change in Ca²⁺: Na⁺ selectivity." Cardiovascular Research 42, no. 2 (1999): 490-502. Full Text
  - Chandra, R, Starmer, CF, and Grant, AO. "Multiple effects of KPQ deletion mutation on gating of human cardiac Na⁺ channels expressed in mammalian cells." American Journal of Physiology Heart and Circulatory Physiology 43, no. 5 (May 1, 1998).
  - Chandra, R, Starmer, CF, and Grant, AO. "Multiple effects of KPQ deletion mutation on gating of human cardiac Na⁺ channels expressed in mammalian cells." American Journal of Physiology Heart and Circulatory Physiology 274, no. 5 43-5 (May 1, 1998).
  - Bonow, RO, Mensah, GA, Bettmann, MA, Gibbons, GH, Grant, AO, Jalife, J, and Robertson, RM. "The working group report on science-based categories for abstracts: Submitted to the annual scientific sessions." Circulation 97, no. 15 (1998): 1525-1528.
  - Bonow, RO, Mensah, GA, Bettmann, MA, Gibbons, GH, Grant, AO, Jalife, J, and Robertson, RM. "The working group report on science-based categories for abstracts: submitted to the annual scientific sessions. American Heart Association." Circulation research 82, no. 7 (1998): 832-835.
  - Bonow, RO, Mensah, GA, Bettmann, MA, Gibbons, GH, Grant, AO, Jalife, J, and Robertson, RM. "The Working Group report on Science-Based Categories for Abstracts: Submitted to the annual scientific sessions. American Heart Association." Arteriosclerosis, thrombosis, and vascular biology 18, no. 4 (1998): 673-676.
  - Bonow, RO, Mensah, GA, Bettmann, MA, Gibbons, GH, Grant, AO, Jalife, J, and Robertson, RM. "The Working Group report on Science-Based Categories for Abstracts: submitted to the annual scientific sessions. The Committee on Scientific Sessions Program (CSSP), American Heart Association." Stroke; a journal of cerebral circulation 29, no. 4 (1998): 881-884.
  - Bonow, RO, Mensah, GA, Bettmann, MA, Gibbons, GH, Grant, AO, Jalife, J, and Robertson, RM. "The working group report on science-based categories for abstracts: Submitted to the annual scientific sessions." Hypertension 31, no. 4 (1998): 1042-1045.
  - Grant, AO. "Proarrhythmia: Classification, Incidence, Risk Factors, Monitoring, Prevention and Management." Cardiac Electrophysiology Review 2, no. 2 (1998): 127-131.
  - Grant, AO. "Mechanisms of Atrial Fibrillation and Action of Drugs Used in Its Management." American Journal of Cardiology 82, no. 7 A (1998): 43N-48N.
  - Reiffel, JA, Grant, AO, Reiffel, JA, Winters, S, Page, R, Webb, C, Kutalek, S, Nademanee, K, Olshansky, B, Carlson, M, and Ferrick, K. "Selecting an antiarrhythmic agent for atrial fibrillation should be a patient-specific, data-driven decision." American Journal of Cardiology 82, no. 8 A (1998): 72N-81N.
  - Nair, LA, and Grant, AO. "Emerging class III antiarrhythmic agents: mechanism of action and proarrhythmic potential." Cardiovasc Drugs Ther 11, no. 2 (April 1997): 149-167. (Review) Link to Item
  - Drazner, MH, Peppel, KC, Dyer, S, Grant, AO, Koch, WJ, and Lefkowitz, RJ. "Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes." The Journal of Clinical Investigation 99, no. 2 (January 1997): 288-296. Full Text Open Access Copy
  - Grant, AO. "Mechanisms of action of antiarrhythmic drugs: From ion channel blockage to arrhythmia termination." PACE - Pacing and Clinical Electrophysiology 20, no. 2 II (1997): 432-444. Full Text
  - Grant, AO, John, JE, Nesterenko, VV, Starmer, CF, and Moorman, JR. "The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels." Mol Pharmacol 50, no. 6 (December 1996): 1643-1650. Link to Item
  - Grant, AO. "Propafenone: an effective agent for the management of supraventricular arrhythmias." J Cardiovasc Electrophysiol 7, no. 4 (April 1996): 353-364. (Review) Link to Item
  - Liu, L, Krinsky, VI, Grant, AO, and Starmer, CF. "Cardiac transient outward potassium current: A pulse chemistry model of frequency-dependent properties." American Journal of Physiology - Heart and Circulatory Physiology 270, no. 1 39-1 (1996): H386-H397.
  - Starmer, CF, Romashko, DN, Reddy, RS, Zilberter, YI, Starobin, J, Grant, AO, and Krinsky, VI. "Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias." Circulation 92, no. 3 (August 1, 1995): 595-605. Link to Item
  - Whalley, DW, Wendt, DJ, and Grant, AO. "Basic concepts in cellular cardiac electrophysiology: Part I: Ion channels, membrane currents, and the action potential." Pacing Clin Electrophysiol 18, no. 8 (August 1995): 1556-1574. (Review) Link to Item
  - Nair, LA, Inglese, J, Stoffel, R, Koch, WJ, Lefkowitz, RJ, Kwatra, MM, and Grant, AO. "Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma." Circulation Research 76, no. 5 (May 1995): 832-838. Full Text
  - Knisley, SB, and Grant, AO. "Asymmetrical electrically induced injury of rabbit ventricular myocytes." Journal of Molecular and Cellular Cardiology 27, no. 5 (1995): 1111-1122.
  - Whalley, DW, Wendt, DJ, and Grant, AO. "Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs." PACE - Pacing and Clinical Electrophysiology 18, no. 9 I (1995): 1686-1704.
  - Liu, L, Wendt, DJ, and Grant, AO. "Relationship between structure and sodium channel blockade by lidocaine and its amino-alkyl derivatives." J Cardiovasc Pharmacol 24, no. 5 (November 1994): 803-812. Link to Item
  - Whalley, DW, Wendt, DJ, Starmer, CF, Rudy, Y, and Grant, AO. "Voltage-independent effects of extracellular K+ on the Na+ current and phase 0 of the action potential in isolated cardiac myocytes." Circ Res 75, no. 3 (September 1994): 491-502. Link to Item
  - Zilberter YuI, , Starmer, CF, Starobin, J, and Grant, AO. "Late Na channels in cardiac cells: the physiological role of background Na channels." Biophysical Journal 67, no. 1 (July 1994): 153-160. Full Text
  - Grant, AO, Wendt, DJ, Zilberter, Y, and Starmer, CF. "Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials." J Membr Biol 136, no. 2 (November 1993): 199-214. Link to Item
  - Knisley, SB, Blitchington, TF, Hill, BC, Grant, AO, Smith, WM, Pilkington, TC, and Ideker, RE. "Optical measurements of transmembrane potential changes during electric field stimulation of ventricular cells." Circ Res 72, no. 2 (February 1993): 255-270. Link to Item
  - Wendt, DJ, Starmer, CF, and Grant, AO. "pH dependence of kinetics and steady-state block of cardiac sodium channels by lidocaine." American Journal of Physiology - Heart and Circulatory Physiology 264, no. 5 33-5 (1993): H1588-H1598.
  - Grant, AO, and Wendt, DJ. "Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones." Trends Pharmacol Sci 13, no. 9 (September 1992): 352-358. (Review) Link to Item
  - Barber, MJ, Wendt, DJ, Starmer, CF, and Grant, AO. "Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs." J Clin Invest 90, no. 2 (August 1992): 368-381. Full Text Link to Item
  - Wendt, DJ, Starmer, CF, and Grant, AO. "Kinetics of interaction of the lidocaine metabolite glycylxylidide with the cardiac sodium channel. Additive blockade with lidocaine." Circ Res 70, no. 6 (June 1992): 1254-1273. Link to Item
  - Jr, AOG. "On the mechanism of action of antiarrhythmic agents." American Heart Journal 123, no. 4 PART 2 (1992): 1130-1136. Full Text
  - Wendt, DJ, Starmer, CF, and Grant, AO. "Na channel kinetics remain stable during perforated-patch recordings." American Journal of Physiology - Cell Physiology 263, no. 6 32-6 (1992): C1234-C1240.
  - Grant, AO. "The electrophysiology of the cardiac sodium channel." Trends Cardiovasc Med 1, no. 8 (December 1991): 321-330. Full Text Link to Item
  - Hurwitz, JL, Dietz, MA, Starmer, CF, and Grant, AO. "A source of bias in the analysis of single channel data: assessing the apparent interaction between channel proteins." Comput Biomed Res 24, no. 6 (December 1991): 584-602. Link to Item
  - Grant, AO. "Models of drug interaction with the sodium channel." Clin Invest Med 14, no. 5 (October 1991): 447-457. (Review) Link to Item
  - Barber, MJ, Starmer, CF, and Grant, AO. "Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin. Evidence for two use-dependent binding sites." Circ Res 69, no. 3 (September 1991): 677-696. Link to Item
  - Starmer, CF, Lastra, AA, Nesterenko, VV, and Grant, AO. "Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments." Circulation 84, no. 3 (September 1991): 1364-1377. Link to Item
  - Starmer, CF, Nesterenko, VV, Undrovinas, AI, Grant, AO, and Rosenshtraukh, LV. "Lidocaine blockade of continuously and transiently accessible sites in cardiac sodium channels." J Mol Cell Cardiol 23 Suppl 1 (February 1991): 73-83. Link to Item
  - Starmer, CF, Nesterenko, VV, Gilliam, FR, and Grant, AO. "Use of ionic currents to identify and estimate parameters in models of channel blockade." The American Journal of Physiology 259, no. 2 Pt 2 (August 1990): H626-H634. Full Text
  - Brown, KK, Yee, R, Grant, AO, and Strauss, HC. "Effects of amiloride on pH regulation in canine cardiac Purkinje fibers." The Journal of Pharmacology and Experimental Therapeutics 254, no. 1 (July 1990): 83-90.
  - Dietz, MA, Grant, AO, and Starmer, CF. "An object oriented user interface for analysis of biological data." Computers and Biomedical Research, an International Journal 23, no. 1 (February 1990): 82-96. Full Text
  - GRANT, AO. "Evolving Concepts of Cardiac Sodium Channel Function." Journal of Cardiovascular Electrophysiology 1, no. 1 (January 1, 1990): 53-67. Full Text
  - Grant, AO. "The cardiac sodium channel: A target for antiarrhythmic drug action." PACE - Pacing and Clinical Electrophysiology 13, no. 11 II (1990): 1541-1552.
  - Grant, AO, Dietz, MA, Gilliam, FR, and Starmer, CF. "Blockade of cardiac sodium channels by lidocaine. Single-channel analysis." Circ Res 65, no. 5 (November 1989): 1247-1262. Link to Item
  - Whitcomb, DC, Gilliam, FR, Starmer, CF, and Grant, AO. "Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine." The Journal of Clinical Investigation 84, no. 5 (November 1989): 1629-1636. Full Text
  - Gilliam, FR, Starmer, CF, and Grant, AO. "Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking." Circ Res 65, no. 3 (September 1989): 723-739. Link to Item
  - Packer, DL, Grant, AO, Strauss, HC, and Starmer, CF. "Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers." J Clin Invest 83, no. 6 (June 1989): 2109-2119. Full Text Link to Item
  - Pelzer, D, Grant, AO, Cavalie, A, Pelzer, S, Sieber, M, Hofmann, F, and Trautwein, W. "Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its α₁ peptide subunit in lipid bilayers." Annals of the New York Academy of Sciences 560 (1989): 138-154.
  - Grant, AO, and Starmer, CF. "Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis." Circ Res 60, no. 6 (June 1987): 897-913. Link to Item
  - Starmer, CF, Packer, DL, and Grant, AO. "Ligand binding to transiently accessible sites: mechanisms for varying apparent binding rates." Journal of Theoretical Biology 124, no. 3 (February 1987): 335-341. Full Text
  - Grant, AO. "Transesophageal electrocardiography and cardiac pacing: discussion." Circulation 75, no. 4 II SUPPL. (1987): III-91-III-92-.
  - Grant, AO. "Transesophageal electrocardiography and cardiac pacing: discussion." Circulation 75, no. 4 II SUPPL. (January 1, 1987).
  - HILL, JA, TRANTHAM, JL, BROWNING, DJ, GRANT, AO, and STRAUSS, HC. "AN UPPER LIMIT FOR THE ELECTROGENIC NA-K PUMP CONTRIBUTION TO MAXIMUM DIASTOLIC POTENTIAL IN FELINE CARDIAC PURKINJE-FIBERS IN STEADY-STATE." CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 64, no. 5 (May 1986): 641-648. Full Text Link to Item
  - Starmer, CF, Dietz, MA, and Grant, AO. "Signal discretization: a source of error in histograms of ion channel events." IEEE Trans Biomed Eng 33, no. 1 (January 1986): 70-73. Link to Item
  - Starmer, CF, and Grant, AO. "Phasic ion channel blockade. A kinetic model and parameter estimation procedure." Mol Pharmacol 28, no. 4 (October 1985): 348-356. Link to Item
  - Stambler, BS, Grant, AO, Broughton, A, and Strauss, HC. "Influence of buffers on dV/dtmax recovery kinetics with lidocaine in myocardium." The American Journal of Physiology 249, no. 3 Pt 2 (September 1985): H663-H671. Full Text
  - Stambler, BS, Grant, AO, Broughton, A, and Strauss, HC. "Influence of buffers on dV/dt(max) recovery kinetics with lidocaine in myocardium." American Journal of Physiology - Heart and Circulatory Physiology 18, no. 3 (1985): H663-H671.
  - Broughton, A, Grant, AO, Starmer, CF, Klinger, JK, Stambler, BS, and Strauss, HC. "Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium." Circ Res 55, no. 4 (October 1984): 513-523. Link to Item
  - Grant, AO, Starmer, CF, and Strauss, HC. "Antiarrhythmic drug action. Blockade of the inward sodium current." Circ Res 55, no. 4 (October 1984): 427-439. (Review) Link to Item
  - Starmer, CF, Grant, AO, and Strauss, HC. "Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics." Biophys J 46, no. 1 (July 1984): 15-27. Full Text Link to Item
  - Grant, AO, Starmer, CF, and Strauss, HC. "Unitary sodium channels in isolated cardiac myocytes of rabbit." Circ Res 53, no. 6 (December 1983): 823-829. Link to Item
  - Kerr, CR, Grant, AO, Wenger, TL, and Strauss, HC. "Sinus node dysfunction." Cardiology Clinics 1, no. 2 (May 1983): 187-207. Full Text
  - III, WWW, Gabliani, G, and Grant, AO. "Patent ductus arteriosus in the elderly." Southern Medical Journal 76, no. 11 (1983): 1436-1437.
  - Smith, WA, Broughton, A, Reiter, MJ, Jr, DWB, Grant, AO, and Gallagher, JJ. "Bystander accessory pathway during AV node re-entrant tachycardia." PACE - Pacing and Clinical Electrophysiology 6, no. 3 I (1983): 537-547.
  - Grant, AO, Trantham, JL, Brown, KK, and Strauss, HC. "PH-Dependent effects of quinidine on the kinetics of dV/dtmax in guinea pig ventricular myocardium." Circulation Research 50, no. 2 (February 1982): 210-217. Full Text
  - Grant, AO, and Strauss, HC. "Intracellular potassium activity in rabbit sinoatrial node. Evaluation during spontaneous activity and arrest." Circulation Research 51, no. 3 (1982): 271-279.
  - SMITH, WM, GALLAGHER, JJ, KERR, CR, SEALY, WC, KASELL, JH, BENSON, DW, REITER, MJ, STERBA, R, and GRANT, AO. "THE ELECTROPHYSIOLOGIC BASIS AND MANAGEMENT OF SYMPTOMATIC RECURRENT TACHYCARDIA IN PATIENTS WITH EBSTEINS-ANOMALY OF THE TRICUSPID-VALVE." AMERICAN JOURNAL OF CARDIOLOGY 49, no. 5 (1982): 1223-1234. Full Text Link to Item
  - Gallagher, JJ, Smith, WM, Kasell, JH, Benson, DW, Sterba, R, and Grant, AO. "Role of Mahaim fibers in cardiac arrhythmias in man." Circulation 64, no. 1 (July 1981): 176-189. Full Text
  - Benditt, DG, Grant, AO, Hutchison, ABS, and Strauss, HC. "Electrophysiological effects of sulfinpyrazone on canine cardiac Purkinje fibers." Canadian Journal of Physiology and Pharmacology 58, no. 6 (1980): 738-742.
  - Gallagher, JJ, Smith, WM, Kasell, J, Grant, AO, and Jr, DWB. "Use of the esophageal lead in the diagnosis of mechanisms of reciprocating supraventricular tachycardia." PACE - Pacing and Clinical Electrophysiology 3, no. 4 (1980): 440-451. Full Text
  - Grant, AO, Strauss, LJ, Wallace, AG, and Strauss, HC. "The influence of pH on the electrophysiological effects of lidocaine in guinea pig ventricular myocardium." Circulation Research 47, no. 4 (1980): 542-550.
  - Benditt, DG, Grant, AO, and Masterton, C. "Effect of pH and [K⁺] on procainamide uptake by mammalian myocardium." Federation Proceedings 38, no. 3 I (January 1, 1979).
  - Grant, AO, Kirkorian, G, Benditt, DG, and Strauss, HC. "The estimation of sinoatrial conduction time in rabbit heart by the constant atrial pacing technique." Circulation 60, no. 3 (1979): 597-604.
  - Grant, AO, Wallace, AG, and Strauss, HC. "Sinus node disease." Herz 4, no. 1 (1979): 1-11.
  - Grant, AO, and Strauss, HC. "The influence of pH on the electrophysiological effects of lidocaine in guinea pig ventricular myocardium." American Journal of Cardiology 43, no. 2 (January 1, 1979): 375-null. Full Text
  - Prystowsky, EN, Grant, AO, Wallace, AG, and Strauss, HC. "An analysis of the effects of acetylcholine on conduction and refractoriness in the rabbit sinus node." Circ Res 44, no. 1 (January 1979): 112-120. Link to Item
  - Grant, AO, Hondeghem, LM, and Katzung, BG. "Effects of droperidol on depolarization-induced automaticity, maximum upstroke velocity [V(max)] and the kinetics of recovery of V(max) in guinea pig ventricular myocardium." Journal of Pharmacology and Experimental Therapeutics 205, no. 1 (1978): 193-203.
  - Grant, AO, and Katzung, BG. "The effects of quinidine and verapamil on electrically induced automaticity in the ventricular myocardium of guinea pig." Journal of Pharmacology and Experimental Therapeutics 196, no. 2 (1976): 407-419.
  - Katzung, BG, Hondeghem, LM, and Grant, AO. "Letter: Cardiac ventricular automaticity induced by current of injury." Pflugers Archiv 360, no. 2 (October 1975): 193-197. Full Text
  - Grant, AO, and Katzung, BG. "Ability of epinephrine, but not increased extracellular calcium, to reverse the effects of Verapamil on ventricular automaticity in vitro." Proceedings of the Western Pharmacology Society Vol.18 (1975): 34-36.
  - Grant, A, Hondeghem, L, and Katzung, B. "Electrophysiologic effects of dehydrobenzperidol in guinea pig papillary muscle in vitro." Pharmacologist 16, no. 2 (January 1, 1974).
  - Hondeghem, LM, Grant, AO, and Jensen, RA. "Antiarrhythmic drug action: Selective depression of hypoxic cardiac cells." American Heart Journal 87, no. 5 (1974): 602-605.
  - Gilliam, FR, Rivas, PA, Wendt, DJ, Starmer, CF, and Grant, AO. "Extracellular pH modulates block of both sodium and calcium channels by nicardipine." American Journal of Physiology Heart and Circulatory Physiology 259, no. 4 28-4 (November 13, 1990).
  - Starmer, CF, Lancaster, AR, Lastra, AA, and Grant, AO. "Cardiac instability amplified by use-dependent Na channel blockade." American Journal of Physiology Heart and Circulatory Physiology 262, no. 4 31-4 (May 27, 1992).
  - Zilberter, YI, Starmer, CF, and Grant, AO. "Open Na⁺ channel blockade: Multiple rest states revealed by channel interactions with disopyramide and quinidine." American Journal of Physiology Heart and Circulatory Physiology 266, no. 5 35-5 (June 13, 1994).
Teaching & Mentoring
Recent Courses
- MEDICINE 442C: Clinical Arrhythmia Service 2019

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Recent Courses