Scholars@Duke
Gregory Cogan

Gregory Cogan

Assistant Professor in Neurology
Neurology, Epilepsy and Sleep
gregory.cogan@duke.edu
200 Trent Drive, Duke South BL, Box 3807, Durham, NC 27710

Selected Publications

A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)-Hydroxynorketamine in Healthy Volunteers.

Journal Article Clin Pharmacol Ther · November 2024 (R,S)-Ketamine (ketamine) is a dissociative anesthetic that also possesses analgesic and antidepressant activity. Undesirable dissociative side effects and misuse potential limit expanded use of ketamine in several mental health disorders despite promising ... Full text Link to item Cite

High-resolution neural recordings improve the accuracy of speech decoding.

Journal Article Nat Commun · November 6, 2023 Patients suffering from debilitating neurodegenerative diseases often lose the ability to communicate, detrimentally affecting their quality of life. One solution to restore communication is to decode signals directly from the brain to enable neural speech ... Full text Link to item Cite

Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.

Journal Article Epilepsia · July 2023 OBJECTIVE: Effective surgical treatment of drug-resistant epilepsy depends on accurate localization of the epileptogenic zone (EZ). High-frequency oscillations (HFOs) are potential biomarkers of the EZ. Previous research has shown that HFOs often occur wit ... Full text Link to item Cite

Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.

Journal Article Brain Commun · 2022 One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% of patients continue to experience seizures following resection. Surgical outcomes may be improved with more ... Full text Open Access Link to item Cite

Flexible, high-resolution thin-film electrodes for human and animal neural research.

Journal Article J Neural Eng · June 17, 2021 Objective.Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding the function of indi ... Full text Link to item Cite

Sufficient sampling for kriging prediction of cortical potential in rat, monkey, and human µECoG.

Journal Article J Neural Eng · March 8, 2021 Objective. Large channel count surface-based electrophysiology arrays (e.g. µECoG) are high-throughput neural interfaces with good chronic stability. Electrode spacing remains ad hoc due to redundancy and nonstationarity of field dynamics. Here, we establi ... Full text Link to item Cite

Translating the brain.

Journal Article Nat Neurosci · April 2020 Full text Link to item Cite

Speech fine structure contains critical temporal cues to support speech segmentation.

Journal Article Neuroimage · November 15, 2019 Segmenting the continuous speech stream into units for further perceptual and linguistic analyses is fundamental to speech recognition. The speech amplitude envelope (SE) has long been considered a fundamental temporal cue for segmenting speech. Does the t ... Full text Link to item Cite

Manipulating stored phonological input during verbal working memory.

Journal Article Nat Neurosci · February 2017 Verbal working memory (vWM) involves storing and manipulating information in phonological sensory input. An influential theory of vWM proposes that manipulation is carried out by a central executive while storage is performed by two interacting systems: a ... Full text Open Access Link to item Cite

I see what you are saying.

Journal Article Elife · June 9, 2016 The motor cortex in the brain tracks lip movements to help with speech perception. ... Full text Open Access Link to item Cite

A kiss is not a kiss: visually evoked neuromagnetic fields reveal differential sensitivities to brief presentations of kissing couples.

Journal Article Neuroreport · September 30, 2015 With a few exceptions, the literature on face recognition and its neural basis derives from the presentation of single faces. However, in many ecologically typical situations, we see more than one face, in different communicative contexts. One of the princ ... Full text Link to item Cite

Sensory-motor transformations for speech occur bilaterally.

Journal Article Nature · March 6, 2014 Historically, the study of speech processing has emphasized a strong link between auditory perceptual input and motor production output. A kind of 'parity' is essential, as both perception- and production-based representations must form a unified interface ... Full text Open Access Link to item Cite

Visual input enhances selective speech envelope tracking in auditory cortex at a "cocktail party".

Journal Article J Neurosci · January 23, 2013 Our ability to selectively attend to one auditory signal amid competing input streams, epitomized by the "Cocktail Party" problem, continues to stimulate research from various approaches. How this demanding perceptual feat is achieved from a neural systems ... Full text Open Access Link to item Cite

A mutual information analysis of neural coding of speech by low-frequency MEG phase information.

Journal Article J Neurophysiol · August 2011 Recent work has implicated low-frequency (<20 Hz) neuronal phase information as important for both auditory (<10 Hz) and speech [theta (∼4-8 Hz)] perception. Activity on the timescale of theta corresponds linguistically to the average length of a syllable, ... Full text Open Access Link to item Cite

A two mechanism model of pure word deafness

Journal Article University of Maryland Working Papers in Linguistics · January 1, 2007 Link to item Cite