Gregory Allan Fleming
Professor of Pediatrics
Clinical interests include pediatric and adult congenital interventional cardiac catheterization and treatment of infants and children with acquired and congenital heart disease and adults with congenital heart disease
Research interests include assessment and development of interventional therapies for congenital heart disease, and perioperative management of infants and children with congenital heart disease requiring surgery.
Research interests include assessment and development of interventional therapies for congenital heart disease, and perioperative management of infants and children with congenital heart disease requiring surgery.
Current Appointments & Affiliations
- Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2022
Contact Information
- DUMC Box 3090, 7506 Hospital North, Durham, NC 27710
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gregory.fleming@duke.edu
(919) 681-6772
- Background
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Education, Training, & Certifications
- Pediatric Cardiology Interventional Fellowship, Pediatrics, Vanderbilt University 2009 - 2010
- Pediatric Cardiology Fellowship, Pediatrics, Vanderbilt University 2006 - 2009
- Internship & Residency, Pediatrics, Vanderbilt University 2003 - 2006
- M.D., University of South Carolina, Columbia 2003
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Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2021 - 2022
- Associate Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2019 - 2020
- Assistant Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2013 - 2019
- Medical Instructor in the Department of Pediatrics, Pediatrics, Cardiology, Pediatrics 2010 - 2012
- Research
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Selected Grants
- Harmony PAS awarded by Medtronic, Inc. 2022 - 2031
- COngenital Multicenter trial of Pulmonic vAlve dysfunction Studying the SAPIEN 3 interventIONal THV Post-Approval Study awarded by Edwards Lifesciences Corporation 2021 - 2026
- Multicenter Post-Approval Study of Congenital Pulmonic Valve Dysfunction Studying the Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with Alterra Adaptive Prestent awarded by Edwards Lifesciences Corporation 2022 - 2024
- COngenital Multicenter trial of Pulmonic vAlve dysfunction Studying the SAPIEN 3 interventIONal THV awarded by Edwards Lifesciences Corporation 2016 - 2021
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External Relationships
- Penumbra
- none
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lim, D Scott, Dennis Kim, Jamil Aboulhosn, Daniel Levi, Greg Fleming, Michael Hainstock, Robert Sommer, et al. “Congenital Pulmonic Valve Dysfunction Treated With SAPIEN 3 Transcatheter Heart Valve (from the COMPASSION S3 Trial).” Am J Cardiol 190 (January 4, 2023): 102–9. https://doi.org/10.1016/j.amjcard.2022.12.010.Full Text Link to Item
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Thornton, Steven W., James M. Meza, Neel K. Prabhu, Lillian Kang, Mary E. Moya-Mendez, Lauren E. Parker, Gregory A. Fleming, Joseph W. Turek, and Nicholas D. Andersen. “Impact of Ventricular Dominance on Long-Term Fontan Outcomes: A 25-year Single-institution Study.” Ann Thorac Surg, December 18, 2022. https://doi.org/10.1016/j.athoracsur.2022.11.039.Full Text Link to Item
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Carmon, Philip, Gregory A. Fleming, Piers C. A. Barker, Gregory M. Sturgeon, Joseph W. Turek, and Reid C. Chamberlain. “Whole-Chest Three-Dimensional Modeling Aids Hybrid Pulmonary Valve Replacement Following Double Switch Operation.” World J Pediatr Congenit Heart Surg, October 20, 2022, 21501351221132160. https://doi.org/10.1177/21501351221132161.Full Text Link to Item
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Fleming, Gregory A., and Reid C. Chamberlain. “Ongoing Learning With Transcatheter Pulmonary Valve Replacement: Incremental Benefits Comparing Apples to Oranges.” Jacc Cardiovasc Interv 15, no. 2 (January 24, 2022): 176–78. https://doi.org/10.1016/j.jcin.2021.12.001.Full Text Link to Item
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Prabhu, Neel K., Alexander Zhu, James M. Meza, Kevin D. Hill, Gregory A. Fleming, Reid C. Chamberlain, Andrew J. Lodge, Joseph W. Turek, and Nicholas D. Andersen. “Transition to Ductal Stenting for Single Ventricle Patients Led to Improved Survival: An Institutional Case Series.” World J Pediatr Congenit Heart Surg 12, no. 4 (July 2021): 518–26. https://doi.org/10.1177/21501351211007808.Full Text Link to Item
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Zhu, Alexander, Carmelo A. Milano, Joseph W. Turek, Richard A. Krasuski, Gregory A. Fleming, Reid C. Chamberlain, and Nicholas D. Andersen. “Mustard Baffle Revision With Systemic Ventricular Assist Device Placement.” Ann Thorac Surg 110, no. 4 (October 2020): e279–80. https://doi.org/10.1016/j.athoracsur.2020.03.038.Full Text Link to Item
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Chamberlain, Reid C., Kevin D. Hill, and Gregory A. Fleming. “Palliating Premature Infants With Obstructed Total Anomalous Pulmonary Venous Connection via Catheterization.” World J Pediatr Congenit Heart Surg 11, no. 4 (July 2020): NP164–67. https://doi.org/10.1177/2150135118782191.Full Text Link to Item
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Chamberlain, Reid C., Jordan E. Ezekian, Gregory M. Sturgeon, Piers C. A. Barker, Kevin D. Hill, and Gregory A. Fleming. “Preprocedural three-dimensional planning aids in transcatheter ductal stent placement: A single-center experience.” Catheter Cardiovasc Interv 95, no. 6 (May 1, 2020): 1141–48. https://doi.org/10.1002/ccd.28669.Full Text Link to Item
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Serfas, John D., Joseph Turek, John Haney, Richard A. Krasuski, and Gregory A. Fleming. “Hybrid transcatheter pulmonary valve replacement with a SAPIEN S3 valve after pulmonary artery banding via left lateral thoracotomy.” Catheter Cardiovasc Interv 95, no. 3 (February 15, 2020): E78–83. https://doi.org/10.1002/ccd.28591.Full Text Link to Item
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Chamberlain, Reid C., Alexis C. Shindhelm, Chu Wang, Gregory A. Fleming, and Kevin D. Hill. “Estimating radiation exposure during paediatric cardiac catheterisation: a potential for radiation reduction with air gap technique.” Cardiol Young 29, no. 12 (December 2019): 1474–80. https://doi.org/10.1017/S1047951119002506.Full Text Link to Item
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Thibault, Dylan, Amelia S. Wallace, Marshall L. Jacobs, Christoph P. Hornik, John M. Costello, Gregory F. Fleming, Jeffrey P. Jacobs, et al. “Postoperative Transcatheter Interventions in Children Undergoing Congenital Heart Surgery.” Circ Cardiovasc Interv 12, no. 6 (June 2019): e007853. https://doi.org/10.1161/CIRCINTERVENTIONS.119.007853.Full Text Link to Item
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Kamyszek, Reed W., Harold J. Leraas, Uttara P. Nag, Lindsey A. Olivere, Amanda L. Nash, Hanna R. Kemeny, Jina Kim, et al. “Routine postprocedure ultrasound increases rate of detection of femoral arterial thrombosis in infants after cardiac catheterization.” Catheter Cardiovasc Interv 93, no. 4 (March 1, 2019): 652–59. https://doi.org/10.1002/ccd.28009.Full Text Link to Item
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Hill, Kevin D., Wei Du, Gregory A. Fleming, Thomas J. Forbes, David G. Nykanen, Jaxk Reeves, Yan Du, and Daisuke Kobayashi. “Validation and refinement of the catheterization RISk score for pediatrics (CRISP score): An analysis from the congenital cardiac interventional study consortium.” Catheter Cardiovasc Interv 93, no. 1 (January 1, 2019): 97–104. https://doi.org/10.1002/ccd.27837.Full Text Link to Item
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Hill, Kevin D., Steve D. Mann, Michael P. Carboni, Thomas P. Doyle, Salim F. Idriss, Dana F. Janssen, George T. Nicholson, Shyam Sathanandam, and Greg A. Fleming. “Variability in radiation dose and image quality: A comparison across fluoroscopy-system vendors, generations of equipment and institutions.” Catheter Cardiovasc Interv 92, no. 7 (December 1, 2018): E471–77. https://doi.org/10.1002/ccd.27793.Full Text Link to Item
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Kenny, Damien, John F. Rhodes, Gregory A. Fleming, Saibal Kar, Evan M. Zahn, Julie Vincent, Girish S. Shirali, et al. “3-Year Outcomes of the Edwards SAPIEN Transcatheter Heart Valve for Conduit Failure in the Pulmonary Position From the COMPASSION Multicenter Clinical Trial.” Jacc Cardiovasc Interv 11, no. 19 (October 8, 2018): 1920–29. https://doi.org/10.1016/j.jcin.2018.06.001.Full Text Link to Item
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Al-Subu, Awni, Edmund Jooste, Christoph P. Hornik, Gregory A. Fleming, Ira M. Cheifetz, and George Ofori-Amanfo. “Correlation between minute carbon dioxide elimination and pulmonary blood flow in single-ventricle patients after stage 1 palliation and 2-ventricle patients with intracardiac shunts: A pilot study.” Paediatr Anaesth 28, no. 7 (July 2018): 618–24. https://doi.org/10.1111/pan.13423.Full Text Link to Item
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“Correction to: 2016 Scientific Sessions Abstract, Variability in Radiation Dose and Image Quality: A Comparison Across Fluoroscopy-system Vendors and Generations of Equipment.” Circulation 137, no. 17 (April 24, 2018). https://doi.org/10.1161/cir.0000000000000572.Full Text
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Gales, Jordan, Richard A. Krasuski, and Gregory A. Fleming. “Transcatheter Valve Replacement for Right-sided Valve Disease in Congenital Heart Patients.” Prog Cardiovasc Dis 61, no. 3–4 (2018): 347–59. https://doi.org/10.1016/j.pcad.2018.09.003.Full Text Open Access Copy Link to Item
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Bearl, David W., and Gregory A. Fleming. “Utilizing Hybrid Techniques to Maximize Clinical Outcomes in Congenital Heart Disease.” Curr Cardiol Rep 19, no. 8 (August 2017): 72. https://doi.org/10.1007/s11886-017-0878-2.Full Text Link to Item
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Hill, Kevin D., Bryan H. Goldstein, Michael J. Angtuaco, Patricia Y. Chu, and Gregory A. Fleming. “Post-market surveillance to detect adverse events associated with Melody® valve implantation.” Cardiol Young 27, no. 6 (August 2017): 1090–97. https://doi.org/10.1017/S1047951116002092.Full Text Link to Item
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Kim, Jina, Zhifei Sun, Ehsan Benrashid, Kevin W. Southerland, Jeffrey H. Lawson, Gregory A. Fleming, Kevin D. Hill, and Elisabeth T. Tracy. “The impact of femoral arterial thrombosis in paediatric cardiac catheterisation: a national study.” Cardiol Young 27, no. 5 (July 2017): 912–17. https://doi.org/10.1017/S104795111600161X.Full Text Link to Item
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Hill, Kevin D., Chu Wang, Andrew J. Einstein, Natalie Januzis, Giao Nguyen, Jennifer S. Li, Gregory A. Fleming, and Terry K. Yoshizumi. “Impact of imaging approach on radiation dose and associated cancer risk in children undergoing cardiac catheterization.” Catheter Cardiovasc Interv 89, no. 5 (April 2017): 888–97. https://doi.org/10.1002/ccd.26630.Full Text Link to Item
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Plummer, Sarah T., Christoph P. Hornik, Hamilton Baker, Gregory A. Fleming, Susan Foerster, M Eric Ferguson, Andrew C. Glatz, et al. “Maladaptive aortic properties after the Norwood procedure: An angiographic analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial.” J Thorac Cardiovasc Surg 152, no. 2 (August 2016): 471-479.e3. https://doi.org/10.1016/j.jtcvs.2016.03.091.Full Text Link to Item
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Torok, Rachel D., Gregory A. Fleming, and Kevin D. Hill. “Transcatheter pulmonary embolectomy after fontan.” Catheter Cardiovasc Interv 87, no. 5 (April 2016): 939–44. https://doi.org/10.1002/ccd.26096.Full Text Link to Item
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Nykanen, David G., Thomas J. Forbes, Wei Du, Abhay A. Divekar, Jaxk H. Reeves, Donald J. Hagler, Thomas E. Fagan, et al. “CRISP: Catheterization RISk score for Pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC).” Catheter Cardiovasc Interv 87, no. 2 (February 1, 2016): 302–9. https://doi.org/10.1002/ccd.26300.Full Text Link to Item
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Torok, Rachel D., Michael J. Campbell, Gregory A. Fleming, and Kevin D. Hill. “Coarctation of the aorta: Management from infancy to adulthood.” World J Cardiol 7, no. 11 (November 26, 2015): 765–75. https://doi.org/10.4330/wjc.v7.i11.765.Full Text Link to Item
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Plummer, Sarah T., Christoph P. Hornik, Hamilton Baker, Gregory A. Fleming, Susan Foerster, Eric Ferguson, Andrew Glatz, et al. “Maladaptive Aortic Properties after the Norwood Procedure: an Angiographic Analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial.” Circulation 130 (November 25, 2014).Link to Item
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Tunks, Robert D., Piers C. A. Barker, Daniel K. Benjamin, Michael Cohen-Wolkowiez, Gregory A. Fleming, Matthew Laughon, Jennifer S. Li, and Kevin D. Hill. “Sildenafil exposure and hemodynamic effect after Fontan surgery.” Pediatr Crit Care Med 15, no. 1 (January 2014): 28–34. https://doi.org/10.1097/PCC.0000000000000007.Full Text Link to Item
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Hill, Kevin D., John F. Rhodes, Ranjit Aiyagari, G Hamilton Baker, Lisa Bergersen, Paul J. Chai, Gregory A. Fleming, et al. “Intervention for recoarctation in the single ventricle reconstruction trial: incidence, risk, and outcomes.” Circulation 128, no. 9 (August 27, 2013): 954–61. https://doi.org/10.1161/CIRCULATIONAHA.112.000488.Full Text Link to Item
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Hill, Kevin D., Robert D. Tunks, Piers C. A. Barker, Daniel K. Benjamin, Michael Cohen-Wolkowiez, Gregory A. Fleming, Matthew Laughon, and Jennifer S. Li. “Sildenafil exposure and hemodynamic effect after stage II single-ventricle surgery.” Pediatr Crit Care Med 14, no. 6 (July 2013): 593–600. https://doi.org/10.1097/PCC.0b013e31828aa5ee.Full Text Link to Item
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Hill, Kevin D., Andrew J. Lodge, Daniel Forsha, Gregory A. Fleming, Amanda S. Green, and John F. Rhodes. “A strategy for atrial septal defect closure in small children that eliminates long-term wall erosion risk.” Catheter Cardiovasc Interv 81, no. 4 (March 2013): 654–59. https://doi.org/10.1002/ccd.24500.Full Text Link to Item
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Hill, Kevin D., John F. Rhodes, Ranjit Aiyagari, G. H. Baker, Lisa Bergersen, Paul J. Chai, Gregory A. Fleming, et al. “Intervention for Re-coarctation in the Single Ventricle Reconstruction Trial: Incidence, Risk and Outcomes.” Circulation 126, no. 21 (November 20, 2012).Link to Item
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Hill, Kevin D., Robert Tunks, Gregory A. Fleming, John F. Rhodes, Matthew Laughon, Michael Cohen-Wolkowiez, and Jennifer S. Li. “Sildenafil Pharmacokinetics, Hemodynamic Efficacy and Safety after Stage II Single Ventricle Surgery.” Circulation 126, no. 21 (November 20, 2012).Link to Item
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Hill, Kevin D., Gregory Fleming, J. Curt Fudge, Erin L. Albers, Thomas P. Doyle, and John F. Rhodes. “Percutaneous interventions in high-risk patients following Mustard repair of transposition of the great arteries.” Catheter Cardiovasc Interv 80, no. 6 (November 15, 2012): 905–14. https://doi.org/10.1002/ccd.23470.Full Text Link to Item
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Fleming, G. A., K. D. Hill, A. S. Green, and J. F. Rhodes. “Percutaneous pulmonary valve replacement.” Progress in Pediatric Cardiology 33, no. 2 (May 1, 2012): 143–50. https://doi.org/10.1016/j.ppedcard.2012.02.007.Full Text
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Fleming, Gregory A., Frederic T. Billings, Tom M. Klein, David P. Bichell, Karla G. Christian, and Mias Pretorius. “Angiotensin-converting enzyme inhibition alters the inflammatory and fibrinolytic response to cardiopulmonary bypass in children.” Pediatr Crit Care Med 12, no. 5 (September 2011): 532–38. https://doi.org/10.1097/PCC.0b013e3181fe3925.Full Text Link to Item
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Fleming, Gregory A., Muhammed Khan, Dana Janssen, and Thomas Doyle. “Angiojet rheolytic thrombectomy in infants following cardiac surgery.” Catheter Cardiovasc Interv 76, no. 2 (August 1, 2010): 233–40. https://doi.org/10.1002/ccd.22544.Full Text Link to Item
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Fleming, G. A., A. Bircher, A. Kavanaugh-McHugh, and M. R. Liske. “The cerebroplacental Doppler ratio predicts postnatal outcome in fetuses with congenital heart block.” J Perinatol 28, no. 12 (December 2008): 791–96. https://doi.org/10.1038/jp.2008.105.Full Text Link to Item
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Fleming, Gregory A., Katherine T. Murray, Chang Yu, John G. Byrne, James P. Greelish, Michael R. Petracek, Steven J. Hoff, Stephen K. Ball, Nancy J. Brown, and Mias Pretorius. “Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery.” Circulation 118, no. 16 (October 14, 2008): 1619–25. https://doi.org/10.1161/CIRCULATIONAHA.108.790162.Full Text Link to Item
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Fleming, G. A., F. G. Scholl, A. Kavanaugh-McHugh, and M. R. Liske. “A case of an infant with flail tricuspid valve due to spontaneous papillary muscle rupture: was neonatal lupus the culprit?” Pediatr Cardiol 29, no. 2 (March 2008): 442–45. https://doi.org/10.1007/s00246-007-9109-8.Full Text Link to Item
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Fleming, Gregory A., Haydar Frangoul, Terence S. Dermody, and Natasha Halasa. “A cord blood transplant recipient with Mycobacterium mucogenicum central venous catheter infection after infusion of tap water.” Pediatr Infect Dis J 25, no. 6 (June 2006): 567–69. https://doi.org/10.1097/01.inf.0000219406.06431.67.Full Text Link to Item
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Book Sections
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Torok, Rachel D., Michael J. Campbell, Gregory A. Fleming, and Kevin D. Hill. “Coarctation of the Aorta.” In Diseases of the Aorta, 111–25. Springer International Publishing, 2019. https://doi.org/10.1007/978-3-030-11322-3_8.Full Text
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Hill, K. D., J. Roark, and G. A. Fleming. “Cardiac catheterization laboratory.” In Critical Heart Disease in Infants and Children, 465-479.e2, 2018. https://doi.org/10.1016/B978-1-4557-0760-7.00037-1.Full Text
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Conference Papers
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Wallace, Amelia S., Marshall L. Jacobs, Christoph P. Hornik, John M. Costello, Gregory A. Fleming, Jeffrey P. Jacobs, Robert D. Jaquiss, Bryan H. Goldstein, Reid C. Chamberlain, and Kevin D. Hill. “Post-operative Cardiac Catheterization in Children Undergoing Congenital Heart Surgery: An Analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.Link to Item
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Kim, Jina, Ibtehaj Naqvi, Uttara P. Nag, Harold J. Leraas, James C. Otto, Alexandra J. Borst, Kevin D. Hill, Gregory A. Fleming, Bruce A. Sullenger, and Elisabeth T. Tracy. “Cell-Free DNA Is Elevated after Acute Arterial Injury in Infants.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.Link to Item
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- Teaching & Mentoring
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Recent Courses
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Teaching Activities
- Director, Advanced fellowship in pediatric and adult congenital congenital interventional cardiology
- Scholarly, Clinical, & Service Activities
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Academic & Administrative Activities
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Medical Director, Pediatric and Adult Congenital Cardiac Cath Labs
Co-director, Duke Fontan program
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Medical Director, Pediatric and Adult Congenital Cardiac Cath Labs
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