Gregory Allan Fleming | Scholars@Duke

Gregory Allan Fleming
Associate Professor of Pediatrics

Clinical interests include pediatric interventional cardiac catheterization and treatment of infants and children with acquired and congenital heart disease.

Research interests include assessment and development of interventional therapies for children with congenital heart disease, and perioperative management of infants and children with congenital heart disease requiring surgery.

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2019

Contact Information

DUMC Box 3090, 7506 Hospital North, Durham, NC 27710
gregory.fleming@duke.edu

Background
Education, Training, & Certifications
- Pediatric Cardiology Interventional Fellowship, Pediatrics, Vanderbilt University 2009 - 2010
- Pediatric Cardiology Fellowship, Pediatrics, Vanderbilt University 2006 - 2009
- Internship & Residency, Pediatrics, Vanderbilt University 2003 - 2006
- M.D., University of South Carolina at Columbia 2003
Duke Appointment History
- Assistant Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2013 - 2019
- Medical Instructor in the Department of Pediatrics, Pediatrics, Cardiology, Pediatrics 2010 - 2012
Research
Selected Grants
- Compassion S3 awarded by Edwards Lifesciences Corporation 2016 - 2021
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kamyszek, RW, Leraas, HJ, Nag, UP, Olivere, LA, Nash, AL, Kemeny, HR, Kim, J, Hill, KD, Fleming, GA, Jooste, EH, Otto, J, and Tracy, ET. "Routine postprocedure ultrasound increases rate of detection of femoral arterial thrombosis in infants after cardiac catheterization." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 93, no. 4 (March 2019): 652-659. Full Text
  - Hill, KD, Du, W, Fleming, GA, Forbes, TJ, Nykanen, DG, Reeves, J, Du, Y, and Kobayashi, D. "Validation and refinement of the catheterization RISk score for pediatrics (CRISP score): An analysis from the congenital cardiac interventional study consortium." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 93, no. 1 (January 2019): 97-104. Full Text
  - Kenny, D, Rhodes, JF, Fleming, GA, Kar, S, Zahn, EM, Vincent, J, Shirali, GS, Gorelick, J, Fogel, MA, Fahey, JT, Kim, DW, Babaliaros, VC, Armstrong, AK, and Hijazi, ZM. "3-Year Outcomes of the Edwards SAPIEN Transcatheter Heart Valve for Conduit Failure in the Pulmonary Position From the COMPASSION Multicenter Clinical Trial." Jacc. Cardiovascular Interventions 11, no. 19 (October 2018): 1920-1929. Full Text
  - Gales, J, Krasuski, RA, and Fleming, GA. "Transcatheter Valve Replacement for Right-sided Valve Disease in Congenital Heart Patients." Progress in Cardiovascular Diseases 61, no. 3-4 (September 17, 2018): 347-359. (Review) Full Text Open Access Copy
  - Chamberlain, RC, Hill, KD, and Fleming, GA. "Palliating Premature Infants With Obstructed Total Anomalous Pulmonary Venous Connection via Catheterization." World Journal for Pediatric & Congenital Heart Surgery (August 22, 2018): 2150135118782191-null. Full Text
  - Al-Subu, A, Jooste, E, Hornik, CP, Fleming, GA, Cheifetz, IM, and Ofori-Amanfo, G. "Correlation between minute carbon dioxide elimination and pulmonary blood flow in single-ventricle patients after stage 1 palliation and 2-ventricle patients with intracardiac shunts: A pilot study." Paediatric Anaesthesia 28, no. 7 (July 2018): 618-624. Full Text
  - "Correction to: 2016 Scientific Sessions Abstract, Variability in Radiation Dose and Image Quality: A Comparison Across Fluoroscopy-system Vendors and Generations of Equipment." Circulation 137, no. 17 (April 24, 2018). Full Text
  - Bearl, DW, and Fleming, GA. "Utilizing Hybrid Techniques to Maximize Clinical Outcomes in Congenital Heart Disease." Current cardiology reports 19, no. 8 (August 2017): 72-. (Review) Full Text
  - Hill, KD, Goldstein, BH, Angtuaco, MJ, Chu, PY, and Fleming, GA. "Post-market surveillance to detect adverse events associated with Melody® valve implantation." Cardiology in the Young 27, no. 6 (August 2017): 1090-1097. (Review) Full Text
  - Kim, J, Sun, Z, Benrashid, E, Southerland, KW, Lawson, JH, Fleming, GA, Hill, KD, and Tracy, ET. "The impact of femoral arterial thrombosis in paediatric cardiac catheterisation: a national study." Cardiology in the Young 27, no. 5 (July 2017): 912-917. Full Text
  - Hill, KD, Wang, C, Einstein, AJ, Januzis, N, Nguyen, G, Li, JS, Fleming, GA, and Yoshizumi, TK. "Impact of imaging approach on radiation dose and associated cancer risk in children undergoing cardiac catheterization." Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 89, no. 5 (April 2017): 888-897. Full Text
  - Plummer, ST, Hornik, CP, Baker, H, Fleming, GA, Foerster, S, Ferguson, ME, Glatz, AC, Hirsch, R, Jacobs, JP, Lee, K-J, Lewis, AB, Li, JS, Martin, M, Porras, D, Radtke, WAK, Rhodes, JF, Vincent, JA, Zampi, JD, and Hill, KD. "Maladaptive aortic properties after the Norwood procedure: An angiographic analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial." The Journal of Thoracic and Cardiovascular Surgery 152, no. 2 (August 2016): 471-479.e3. Full Text
  - Torok, RD, Fleming, GA, and Hill, KD. "Transcatheter pulmonary embolectomy after fontan." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 87, no. 5 (April 2016): 939-944. Full Text
  - Nykanen, DG, Forbes, TJ, Du, W, Divekar, AA, Reeves, JH, Hagler, DJ, Fagan, TE, Pedra, CAC, Fleming, GA, Khan, DM, Javois, AJ, Gruenstein, DH, Qureshi, SA, Moore, PM, Wax, DH, and Congenital Cardiac Interventional Study Consortium (CCISC), . "CRISP: Catheterization RISk score for Pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC)." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 87, no. 2 (February 2016): 302-309. Full Text
  - Torok, RD, Campbell, MJ, Fleming, GA, and Hill, KD. "Coarctation of the aorta: Management from infancy to adulthood." World Journal of Cardiology 7, no. 11 (November 2015): 765-775. (Review) Full Text
  - Plummer, ST, Hornik, CP, Baker, H, Fleming, GA, Foerster, S, Ferguson, E, Glatz, A, Hirsch, R, Jacobs, JP, Lee, K-J, Lewis, A, Li, JS, Martin, MH, Porras, D, Radtke, WA, Rhodes, JF, Vincent, JA, Zampi, JD, and Hill, KD. "Maladaptive Aortic Properties after the Norwood Procedure: an Angiographic Analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial." CIRCULATION 130 (November 25, 2014). Link to Item
  - Tunks, RD, Barker, PCA, Benjamin, DK, Cohen-Wolkowiez, M, Fleming, GA, Laughon, M, Li, JS, and Hill, KD. "Sildenafil exposure and hemodynamic effect after fontan surgery." Pediatric Critical Care Medicine 15, no. 1 (January 1, 2014): 28-34. Full Text
  - Tunks, RD, Barker, PCA, Benjamin, DK, Cohen-Wolkowiez, M, Fleming, GA, Laughon, M, Li, JS, and Hill, KD. "Sildenafil exposure and hemodynamic effect after Fontan surgery." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 15, no. 1 (January 2014): 28-34. Full Text
  - Hill, KD, Rhodes, JF, Aiyagari, R, Baker, GH, Bergersen, L, Chai, PJ, Fleming, GA, Fudge, JC, Gillespie, MJ, Gray, RG, Hirsch, R, Lee, K-J, Li, JS, Ohye, RG, Oster, ME, Pasquali, SK, Pelech, AN, Radtke, WAK, Takao, CM, Vincent, JA, and Hornik, CP. "Intervention for recoarctation in the single ventricle reconstruction trial: incidence, risk, and outcomes." Circulation 128, no. 9 (August 2013): 954-961. Full Text
  - Hill, KD, Tunks, RD, Barker, PCA, Benjamin, DK, Cohen-Wolkowiez, M, Fleming, GA, Laughon, M, and Li, JS. "Sildenafil exposure and hemodynamic effect after stage II single-ventricle surgery." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 14, no. 6 (July 2013): 593-600. Full Text
  - Hill, KD, Lodge, AJ, Forsha, D, Fleming, GA, Green, AS, and Rhodes, JF. "A strategy for atrial septal defect closure in small children that eliminates long-term wall erosion risk." Catheter Cardiovasc Interv 81, no. 4 (March 2013): 654-659. Full Text Link to Item
  - Hill, KD, Lodge, AJ, Forsha, D, Fleming, GA, Green, AS, and Rhodes, JF. "A strategy for atrial septal defect closure in small children that eliminates long-term wall erosion risk." Catheterization and Cardiovascular Interventions 81, no. 4 (2013): 654-659. Full Text
  - Hill, KD, Rhodes, JF, Aiyagari, R, Baker, GH, Bergersen, L, Chai, PJ, Fleming, GA, Fudge, JC, Gillespie, MJ, Gray, RG, Hirsch, R, Lee, K-J, Li, JS, Ohye, RG, Oster, ME, Pasquali, SK, Pelech, AN, Radtke, WAK, Takao, CM, Vincent, JA, and Hornik, CP. "Intervention for recoarctation in the single ventricle reconstruction trial: Incidence, risk, and outcomes." Circulation 128, no. 9 (2013): 954-961. Full Text
  - Hill, KD, Rhodes, JF, Aiyagari, R, Baker, GH, Bergersen, L, Chai, PJ, Fleming, GA, Fudge, JC, Gillespie, MJ, Gray, RG, Hirsch, R, Lee, K-J, Li, JS, Ohye, RG, Oster, ME, Pasquali, SK, Pelech, AM, Radtke, WA, Takao, CM, Vincent, JA, and Hornik, CP. "Intervention for Re-coarctation in the Single Ventricle Reconstruction Trial: Incidence, Risk and Outcomes." CIRCULATION 126, no. 21 (November 20, 2012). Link to Item
  - Hill, KD, Tunks, R, Fleming, GA, Rhodes, JF, Laughon, M, Cohen-Wolkowiez, M, and Li, JS. "Sildenafil Pharmacokinetics, Hemodynamic Efficacy and Safety after Stage II Single Ventricle Surgery." CIRCULATION 126, no. 21 (November 20, 2012). Link to Item
  - Hill, KD, Fleming, G, Curt Fudge, J, Albers, EL, Doyle, TP, and Rhodes, JF. "Percutaneous interventions in high-risk patients following Mustard repair of transposition of the great arteries." Catheter Cardiovasc Interv 80, no. 6 (November 15, 2012): 905-914. Full Text Link to Item
  - Fleming, GA, Hill, KD, Green, AS, and Rhodes, JF. "Percutaneous pulmonary valve replacement." Progress in Pediatric Cardiology 33, no. 2 (May 1, 2012): 143-150. Full Text
  - Fleming, GA, Billings, FT, Klein, TM, Bichell, DP, Christian, KG, and Pretorius, M. "Angiotensin-converting enzyme inhibition alters the inflammatory and fibrinolytic response to cardiopulmonary bypass in children." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 12, no. 5 (September 2011): 532-538. Full Text
  - Fleming, GA, Khan, M, Janssen, D, and Doyle, T. "Angiojet rheolytic thrombectomy in infants following cardiac surgery." Catheter Cardiovasc Interv 76, no. 2 (August 1, 2010): 233-240. Full Text Link to Item
  - Fleming, GA, Bircher, A, Kavanaugh-McHugh, A, and Liske, MR. "The cerebroplacental Doppler ratio predicts postnatal outcome in fetuses with congenital heart block." J Perinatol 28, no. 12 (December 2008): 791-796. Full Text Link to Item
  - Fleming, GA, Murray, KT, Yu, C, Byrne, JG, Greelish, JP, Petracek, MR, Hoff, SJ, Ball, SK, Brown, NJ, and Pretorius, M. "Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery." Circulation 118, no. 16 (October 2008): 1619-1625. Full Text
  - Fleming, GA, Scholl, FG, Kavanaugh-McHugh, A, and Liske, MR. "A case of an infant with flail tricuspid valve due to spontaneous papillary muscle rupture: was neonatal lupus the culprit?." Pediatr Cardiol 29, no. 2 (March 2008): 442-445. Full Text Link to Item
  - Fleming, GA, Frangoul, H, Dermody, TS, and Halasa, N. "A cord blood transplant recipient with Mycobacterium mucogenicum central venous catheter infection after infusion of tap water." Pediatr Infect Dis J 25, no. 6 (June 2006): 567-569. Full Text Link to Item
- Conference Papers
  - Hill, KD, Mann, SD, Carboni, MP, Doyle, TP, Idriss, SF, Janssen, DF, Nicholson, GT, Sathanandam, S, and Fleming, GA. "Variability in radiation dose and image quality: A comparison across fluoroscopy-system vendors, generations of equipment and institutions." December 2018. Full Text
  - Wallace, AS, Jacobs, ML, Hornik, CP, Costello, JM, Fleming, GA, Jacobs, JP, Jaquiss, RD, Goldstein, BH, Chamberlain, RC, and Hill, KD. "Post-operative Cardiac Catheterization in Children Undergoing Congenital Heart Surgery: An Analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017. Link to Item
  - Kim, J, Naqvi, I, Nag, UP, Leraas, HJ, Otto, JC, Borst, AJ, Hill, KD, Fleming, GA, Sullenger, BA, and Tracy, ET. "Cell-Free DNA Is Elevated after Acute Arterial Injury in Infants." 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). San Diego, CA. December 3, 2016 - December 6, 2016.: AMER SOC HEMATOLOGY, December 2, 2016. Link to Item
Teaching & Mentoring
Recent Courses
- PEDS 229C: Pediatric Congenital Cardiology 2019

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses