Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., University of Western Ontario (Canada) 2009
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  Previous Appointments & Affiliations

  • Assistant Professor in Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2016 - 2020
  • Assistant Professor in Pathology, Pathology, Clinical Science Departments 2017 - 2020
• Recognition
• 

  In the News

  • SEP 19, 2019

    No Bones About It, This Protein Slows Down Fracture-Healing
• Research
• 

  Selected Grants

  • Localization of adenosine to promote fracture healing awarded by National Institutes of Health 2022 - 2027
  • Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers awarded by National Institutes of Health 2021 - 2025
  • Assessing healthspan in aged mice after prolonged exposure to young circulation awarded by National Institutes of Health 2020 - 2023
  • Correction of Immune Response Improves Aged Fracture Healing awarded by National Institutes of Health 2020 - 2023
  • Extracellular Vesicles and Their Role in Hallmarks of Aging awarded by National Institutes of Health 2018 - 2020
  • Investigating the role of Apolipoprotein E in pseudarthrosis following spinal fusion surgery awarded by AOSpine International 2019 - 2020
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Poganik, Jesse R., Bohan Zhang, Gurpreet S. Baht, Alexander Tyshkovskiy, Amy Deik, Csaba Kerepesi, Sun Hee Yim, et al. “Biological age is increased by stress and restored upon recovery.” Cell Metab 35, no. 5 (May 2, 2023): 807-820.e5. https://doi.org/10.1016/j.cmet.2023.03.015.
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    • Yan, Ruorong, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, et al. “An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.” Cell Stem Cell 30, no. 1 (January 5, 2023): 96-111.e6. https://doi.org/10.1016/j.stem.2022.11.012.
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    • Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nat Commun 13, no. 1 (December 9, 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.
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    • Huang, Rong, Abhinav R. Balu, Kristin H. Molitoris, James P. White, Alexander G. Robling, Ugur M. Ayturk, and Gurpreet S. Baht. “The role of Meteorin-like in skeletal development and bone fracture healing.” J Orthop Res 40, no. 11 (November 2022): 2510–21. https://doi.org/10.1002/jor.25286.
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    • Zhang, Xin, Gurpreet Singh Baht, Rong Huang, Yu-Hsiu Chen, Kristin Happ Molitoris, Sara E. Miller, and Virginia Byers Kraus. “Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.” Aging Cell 21, no. 7 (July 2022): e13651. https://doi.org/10.1111/acel.13651.
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    • Huang, Rong, Linda Vi, Xiaohua Zong, and Gurpreet S. Baht. “Maresin 1 resolves aged-associated macrophage inflammation to improve bone regeneration.” Faseb J 34, no. 10 (October 2020): 13521–32. https://doi.org/10.1096/fj.202001145R.
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    • Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 8 (August 2020): 794. https://doi.org/10.1038/s42255-020-0257-y.
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    • Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 3 (March 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.
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    • Zeng, Yuze, Yu-Ru V. Shih, Gurpreet S. Baht, and Shyni Varghese. “In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.” Adv Mater 32, no. 8 (February 2020): e1906022. https://doi.org/10.1002/adma.201906022.
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    • Miller-Rhodes, Patrick, Cuicui Kong, Gurpreet S. Baht, Priyanka Saminathan, Ramona M. Rodriguiz, William C. Wetsel, Harris A. Gelbard, and Niccolò Terrando. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.” J Neuroinflammation 16, no. 1 (October 28, 2019): 193. https://doi.org/10.1186/s12974-019-1582-5.
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    • Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing.” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.
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    • Miller-Rhodes, Patrick, Cuicui Kong, Gurpreet Baht, Ramona Rodriguiz, William Wetsel, Harris Gelbard, and Niccolò Terrando. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders,” February 2019. https://doi.org/10.1101/537472.
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    • Vi, Linda, Gurpreet S. Baht, Erik J. Soderblom, Heather Whetstone, Qingxia Wei, Bridgette Furman, Vijitha Puviindran, et al. “Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.” Nat Commun 9, no. 1 (December 5, 2018): 5191. https://doi.org/10.1038/s41467-018-07666-0.
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    • Baht, Gurpreet S., Linda Vi, and Benjamin A. Alman. “The Role of the Immune Cells in Fracture Healing.” Curr Osteoporos Rep 16, no. 2 (April 2018): 138–45. https://doi.org/10.1007/s11914-018-0423-2.
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    • Xiong, Chao, Zhiquan Zhang, Gurpreet S. Baht, and Niccolo Terrando. “A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration.” J Vis Exp, no. 132 (February 27, 2018). https://doi.org/10.3791/56701.
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    • Baht, Gurpreet S., Puviindran Nadesan, David Silkstone, and Benjamin A. Alman. “Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair.” Bone 98 (May 2017): 31–36. https://doi.org/10.1016/j.bone.2017.02.012.
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    • Ng, Adeline H., Gurpreet S. Baht, Benjamin A. Alman, and Marc D. Grynpas. “Bone Marrow Stress Decreases Osteogenic Progenitors.” Calcif Tissue Int 97, no. 5 (November 2015): 476–86. https://doi.org/10.1007/s00223-015-0032-3.
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    • Baht, Gurpreet S., David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei, and Benjamin A. Alman. “Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin.” Nat Commun 6 (August 26, 2015): 7761. https://doi.org/10.1038/ncomms8761.
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    • Vi, Linda, Gurpreet S. Baht, Heather Whetstone, Adeline Ng, Qingxia Wei, Raymond Poon, Sivakami Mylvaganam, Marc Grynpas, and Benjamin A. Alman. “Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.” J Bone Miner Res 30, no. 6 (June 2015): 1090–1102. https://doi.org/10.1002/jbmr.2422.
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    • Baht, Gurpreet S., David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei, and Benjamin A. Alman. “Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.” Nat Commun 6 (May 19, 2015): 7131. https://doi.org/10.1038/ncomms8131.
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    • Baht, Gurpreet S., David Silkstone, Puviindran Nadesan, Heather Whetstone, and Benjamin A. Alman. “Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.” J Orthop Res 32, no. 4 (April 2014): 581–86. https://doi.org/10.1002/jor.22562.
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    • Craft, April M., Nazish Ahmed, Jason S. Rockel, Gurpreet S. Baht, Benjamin A. Alman, Rita A. Kandel, Agamemnon E. Grigoriadis, and Gordon M. Keller. “Specification of chondrocytes and cartilage tissues from embryonic stem cells.” Development 140, no. 12 (June 2013): 2597–2610. https://doi.org/10.1242/dev.087890.
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    • Baht, Gurpreet S., Jason O’Young, Antonia Borovina, Hong Chen, Coralee E. Tye, Mikko Karttunen, Gilles A. Lajoie, Graeme K. Hunter, and Harvey A. Goldberg. “Phosphorylation of Ser136 is critical for potent bone sialoprotein-mediated nucleation of hydroxyapatite crystals.” Biochem J 428, no. 3 (May 27, 2010): 385–95. https://doi.org/10.1042/BJ20091864.
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    • Baht, Gurpreet S., Graeme K. Hunter, and Harvey A. Goldberg. “Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation.” Matrix Biol 27, no. 7 (September 2008): 600–608. https://doi.org/10.1016/j.matbio.2008.06.004.
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  • Book Sections

    • Alman, Benjamin, and Gurpreet Baht. “Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton.,” 2230:105–13, 2021. https://doi.org/10.1007/978-1-0716-1028-2_7.
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  • Conference Papers

    • Balu, Abhinav, Rong Huang, Kristin Molitoris, and Gurpreet Baht. “APOLIPOPROTEIN E IMPAIRS AGED BONE FRACTURE HEALING.” In Innovation in Aging, 5:662–662, 2021.
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    • Huang, Rong, Linda Vi, Xiaohua Zong, and Gurpreet Baht. “Maresin 1 resolves macrophage inflammation to improve aged bone fracture healing.” In Journal of Bone and Mineral Research, 35:163–163, 2020.
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    • Zong, Xiaohua, Puviindran Nadesan, James White, Phillip White, and Gurpreet Baht. “The role of apolipoprotein E in fracture healing and osteoblast differentiation.” In Journal of Bone and Mineral Research, 33:9–9. WILEY, 2018.
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    • Nadesan, Puviindran, and Gurpreet Baht. “A Role for Apolipoprotein E in Fracture Healing.” In Journal of Bone and Mineral Research, 32:S125–26. WILEY, 2017.
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    • Ng, Adeline, Gurpreet Baht, Marc Grynpas, and Benjamin Alman. “Osteoblast depletion increases osteoblast activity and reduces bone toughness in mice.” In Journal of Bone and Mineral Research, 29:S346–S346. WILEY-BLACKWELL, 2014.
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    • Baht, Gurpreet, and Benjamin Alman. “Rejuvenating Bone Fracture Repair.” In Journal of Bone and Mineral Research, Vol. 28. WILEY-BLACKWELL, 2013.
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    • Ng, Adeline, Gurpreet Baht, Marc Grynpas, and Benjamin Alman. “Repeated Osteoblast Depletion Decreases Osteogenic Potential of Bone Marrow Stromal Cells in Mice.” In Journal of Bone and Mineral Research, Vol. 28. WILEY-BLACKWELL, 2013.
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    • Baht, G. S., G. K. Hunter, and H. A. Goldberg. “Bone sialoprotein-mediated mineral formation: Role of phosphorylation & development of a fusion peptide for bone repair.” In European Cells and Materials, 16:43, 2008.
    • Goldberg, H. A., G. Baht, J. Gordon, V. Pitelka, H. Chen, D. Holdsworth, and G. K. Hunter. “Bone repair mediated by bone sialoprotein.” In European Cells and Materials, 16:47, 2008.
• Teaching & Mentoring
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  Recent Courses

  • PATHOL 293: Research Independent Study 2021

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