Gregory Allan Wray
Professor of Biology
I study the evolution of genes and genomes with the broad aim of understanding the origins of biological diversity. My approach focuses on changes in the expression of genes using both empirical and computational approaches and spans scales of biological organization from single nucleotides through gene networks to entire genomes. At the finer end of this spectrum of scale, I am focusing on understanding the functional consequences and fitness components of specific genetic variants within regulatory sequences of several genes associated with ecologically relevant traits. At the other end of the scale, I am developing molecular and analytical methods to detect changes in gene function throughout entire genomes, including statistical frameworks for detecting natural selection on regulatory elements and empirical approaches to identify functional variation in transcriptional regulation. At intermediate scales, I am investigating functional variation within a dense gene network in the context of wild populations and natural perturbations. My research leverages the advantages of several different model systems, but primarily focuses on sea urchins and primates (including humans).
Current Appointments & Affiliations
- Professor of Biology, Biology, Trinity College of Arts & Sciences 2005
- Professor of Evolutionary Anthropology, Evolutionary Anthropology, Trinity College of Arts & Sciences 2008
- Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2020
- Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Contact Information
- 125 Science Drive, 4104 French Family Science Center, Durham, NC 27708
- Duke Box 90325, Durham, NC 27708-0325
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gwray@duke.edu
(919) 684-6696
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Wray Lab
- Background
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Education, Training, & Certifications
- Ph.D., Duke University 1987
- B.S., College of William and Mary 1981
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Previous Appointments & Affiliations
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018 - 2021
- Director of the Center for Genomic and Computational Biology, Duke Center for Genomic and Computational Biology, Institutes and Centers 2014 - 2020
- Director of the IGSP Center for Evolutionary Genomics, Institutes and Centers, School of Medicine 2010 - 2015
- Associate Professor of Biology, Biology, Trinity College of Arts & Sciences 2000 - 2005
- Visiting Associate Professor of Zoology, Biology, Trinity College of Arts & Sciences 1999 - 2000
- Recognition
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In the News
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MAR 4, 2021 -
OCT 15, 2020 -
JUN 26, 2019 -
NOV 27, 2018 -
MAR 16, 2016 -
MAR 16, 2016 Duke Today -
NOV 11, 2015 Quanta Magazine -
AUG 14, 2015 The New York Times -
JUN 26, 2015 -
JUN 26, 2015 Duke Today -
FEB 19, 2015 -
FEB 19, 2015 Duke Today -
JUN 16, 2014 Duke Research Blog -
JUN 16, 2014 Duke Research Blog -
MAY 5, 2014 -
MAR 24, 2014 -
JAN 30, 2014 Duke Research Blog
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Awards & Honors
- AAAS Fellow. American Association for the Advancement of Science. 2019
- Distinguished Visiting Professor. University of Miami. 2018
- Houpt Lecture in Genome Sciences. University of North Carolina, Chapel Hill. 2012
- Huck Lecture in Molecular Evolution. Pennsylvania State University. 2010
- Daniel Koshland Lecture. University of California at Berkeley. 2009
- Donald Abbott Lecture. Stanford University, Hopkins Marine Lab. 2004
- J. B. Johnson Lecture. Society for Neuroscience. 2001
- Young Investigator in Molecular Evolution. Alfred P. Sloan Foundation. 1995
- NRSA Postdoctoral Fellowship. National Institutes of Health. 1988
- Graduate Research Fellowship. National Science Foundation. 1982
- Expertise
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Subject Headings
- 5' Flanking Region
- Adaptation
- Adaptation, Biological
- Adaptation, Physiological
- Adipose Tissue
- Alleles
- Allelic Imbalance
- Alternative Splicing
- Amino Acid Sequence
- Analysis of Variance
- Animals
- Animals, Wild
- Ants
- Aquaculture
- Arabidopsis
- Archaea
- Autoimmune Diseases
- Bacteria
- Base Sequence
- Bayes Theorem
- Beetles
- Behavior, Animal
- Binding Sites
- Biological Evolution
- Biological Markers
- Body Patterning
- Bone and Bones
- Brain
- Brain Chemistry
- Bryophyta
- Calcification, Physiologic
- Cell Adhesion Molecules
- Cell Culture Techniques
- Cell Differentiation
- Cell Line
- Cell Line, Tumor
- Cell Size
- Cells, Cultured
- Centromere
- Cerebral Cortex
- Chromatin
- Chromatin Immunoprecipitation
- Chromosomes, Human, Pair 17
- Climate Change
- Cloning, Molecular
- Cognition
- Competitive Behavior
- Complement Activation
- Computational Biology
- Consensus Sequence
- Conserved Sequence
- Coronary Artery Disease
- Creatine Kinase, BB Form
- Creatine Kinase, MM Form
- Creatine Kinase, Mitochondrial Form
- Culture Media
- DNA
- DNA Primers
- DNA, Intergenic
- DNA, Satellite
- DNA-Binding Proteins
- Databases, Genetic
- Dental Enamel Proteins
- Deoxyribonuclease I
- Diet
- Drosophila Proteins
- Duffy Blood-Group System
- Echinodermata
- Ecology
- Ecosystem
- Embryo, Nonmammalian
- Embryonic Development
- Energy Metabolism
- Enhancer Elements, Genetic
- Enkephalins
- Environment
- Eukaryota
- Eukaryotic Cells
- Evolution, Molecular
- Evolutionary genetics
- Extracellular Matrix Proteins
- Factor VII
- Female
- Fibroblasts
- Fluorescent Antibody Technique
- Forecasting
- Gastrula
- Gene Duplication
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Plant
- Gene Frequency
- Gene Regulatory Networks
- Gene-Environment Interaction
- Genes
- Genes, Developmental
- Genes, Homeobox
- Genes, Insect
- Genes, Regulator
- Genes, Reporter
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Genetic Variation
- Genetics, Population
- Genome
- Genome, Human
- Genome-Wide Association Study
- Genomics
- Genotype
- Geography
- Germ Cells, Plant
- Germ Layers
- Glucose Transporter Type 4
- Gorilla gorilla
- HLA-DQ Antigens
- Haemosporida
- Haplotypes
- Helminths
- Homeodomain Proteins
- Hominidae
- Human Genome Project
- Humans
- Hypersensitivity
- Immunity, Innate
- Immunohistochemistry
- Immunologic Factors
- Insect Proteins
- Interleukin-4
- Introns
- Kenya
- Larva
- Lemur
- Life Cycle Stages
- Likelihood Functions
- Liver
- Lytechinus
- Macaca
- Macaca mulatta
- Madagascar
- Malaria
- Male
- Matrix Metalloproteinase 3
- Membrane Transport Proteins
- Mesoderm
- Metamorphosis
- Metamorphosis, Biological
- Mice
- Microsatellite Repeats
- Microscopy, Electron
- Models, Genetic
- Models, Statistical
- Models, Theoretical
- Molecular Sequence Data
- Morphogenesis
- Muscle, Skeletal
- Mutation
- NFATC Transcription Factors
- Narcotics
- Nervous System
- Nervous System Physiological Phenomena
- Neurons
- Nuclear Proteins
- Nucleotide Motifs
- Nutrigenomics
- Oligonucleotide Array Sequence Analysis
- Oocytes
- Opioid Peptides
- Organ Size
- Organ Specificity
- Pan troglodytes
- Papio
- Papio cynocephalus
- Petroleum
- Phenotype
- Phosphocreatine
- Phosphoproteins
- Phylogeny
- Plasmodium vivax
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Pongo pygmaeus
- Prevalence
- Primates
- Promoter Regions, Genetic
- Protein Binding
- Protein Biosynthesis
- Protein Precursors
- Protein Processing, Post-Translational
- Proteins
- Quantitative Trait Loci
- Real-Time Polymerase Chain Reaction
- Receptors, Cell Surface
- Reference Standards
- Regression Analysis
- Regulatory Elements, Transcriptional
- Regulatory Sequences, Nucleic Acid
- Reproducibility of Results
- Reproduction
- Response Elements
- Retroelements
- Reverse Transcriptase Polymerase Chain Reaction
- Saccharomyces cerevisiae
- Sea Urchins
- Selection, Genetic
- Sequence Alignment
- Sequence Analysis, DNA
- Sequence Analysis, RNA
- Sequence Homology
- Sequence Homology, Nucleic Acid
- Sex Factors
- Signal Transduction
- Social Dominance
- Social Environment
- Sodium-Phosphate Cotransporter Proteins, Type III
- Species Specificity
- Statistics, Nonparametric
- Stem Cells
- Stromal Cells
- Strongylocentrotus purpuratus
- Systems Biology
- Temperature
- Th2 Cells
- Time Factors
- Transcription Factors
- Transcription Initiation Site
- Transcription, Genetic
- Transcriptional Activation
- Transcriptome
- Transfection
- Tyrosine 3-Monooxygenase
- Untranslated Regions
- Vertebrates
- Wing
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Global Scholarship
- Research
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Selected Grants
- Evolutionary dynamics of zoonotic malaria awarded by National Institutes of Health 2023 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Collaborative Research: RoL: The intersection between cell fate decisions and phenotypic diversification in a rapidly radiating butterfly lineage awarded by National Science Foundation 2021 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Characterizing new redox roles for protein ubiquitination in human cells awarded by National Institutes of Health 2022 - 2024
- Genomics, variation, and evolution of cerebellar circuits linked to higher cognitive functions in humans awarded by National Institutes of Health 2021 - 2023
- The Duke FUNCTION Center: Pioneering the comprehensive identification of combinatorial noncoding causes of disease awarded by National Institutes of Health 2020 - 2023
- Natural Selection in Admixed Populations awarded by National Institutes of Health 2020 - 2023
- Preparing Genetic Counselors for Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation 2019 - 2023
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 2023
- Evolution of a developmental gene regulatory network during a life history switch in Heliocidaris awarded by National Science Foundation 2019 - 2022
- Impacts of the African Origin of Plasmodium vivax on Contemporary Parasite Populations awarded by University of North Carolina - Chapel Hill 2017 - 2022
- NRT: Integrative Bioinformatics for Investigating and Engineering Microbiomes (IBIEM) awarded by National Science Foundation 2015 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Decoding schizophrenia-From GWAS to functional regulatory variants awarded by National Institutes of Health 2014 - 2019
- Global Genetic Diversity Study for Malaria awarded by Naval Medical Research Center 2017 - 2018
- Evolutionary Rewiring of a Developmental Gene Regulatory Network awarded by National Science Foundation 2015 - 2018
- Genetics and Evolution of Fetal Human Fat Accretion During Development awarded by Northwestern University 2013 - 2018
- Doctoral Dissertation Research: Investigation of the Evolution of Human Adipocytes Using iPSCs awarded by National Science Foundation 2017 - 2018
- HARDAC+:Reproducible HPC for next-generation genomics awarded by North Carolina Biotechnology Center 2016 - 2017
- Collaborative Research: Assembling the Echinoderm Tree of Life awarded by National Science Foundation 2011 - 2015
- Automated Library Preparation System for Next-Generation Sequencing awarded by North Carolina Biotechnology Center 2014 - 2015
- Collaborative Research: Genetic Bases for the Evolution of Human Diet awarded by National Science Foundation 2008 - 2014
- Truncated GLI1 In Glioblastoma awarded by National Institutes of Health 2014
- Collaborative Research: Genes, environment and gene expression in a wild primate population awarded by National Science Foundation 2009 - 2013
- Cross-species analysis of myocardial susceptibility to perioperative stress awarded by National Institutes of Health 2007 - 2013
- Modeling the structure & evolution of regulatory regions in eukaryotic genomes awarded by National Institutes of Health 2007 - 2013
- Illumina Hi-Seq 2000 Sequencing System awarded by National Institutes of Health 2012 - 2013
- DISSERTATION RESEARCH: Selection, drift, and constraint in the evolution of a developmental regulatory gene network awarded by National Science Foundation 2009 - 2012
- Evolutionary Genetics of a Sea Urchin Skeletogenic Gene Network awarded by National Science Foundation 2006 - 2010
- High-performance Computing System for Bioinformatics awarded by National Institutes of Health 2009 - 2010
- REU Site: Explorations in the Genome Sciences awarded by National Science Foundation 2006 - 2010
- Dissertation Research: Contribution of Mutations within Cis-Regulatory DNA to Molecular Phenotype and Organismal Fitness awarded by National Science Foundation 2005 - 2007
- Evolution of Endo 16 promoter function within camarodont sea urchins awarded by National Aeronautics and Space Administration 2002 - 2006
- Population Genetics of Promoter Sequences in Echinoids awarded by National Science Foundation 2003 - 2006
- Workshop on Developmental Physiology awarded by National Science Foundation 2004 - 2005
- DISSERTATION RESEARCH: Molecular evolution of the Endo16 cis-regulatory system (J. Balhoff) awarded by National Science Foundation 2002 - 2005
- High-throughput determination of position weight matrices awarded by National Science Foundation 2004 - 2005
- DISSERTATION RESEARCH: The structure of heritable variation in developmental gene expression in the purple urchin awarded by National Science Foundation 2003 - 2004
- Dissertation Research: Evolution and Development of Left-Right Asymmetry in Echinoderms awarded by National Science Foundation 2001 - 2003
- REU Supplement: Molecular bases for the evolution of new developmental roles in two homeobox genes awarded by National Science Foundation 2000 - 2003
- Evolution of a Gene Regulatory System: Structural and Functional Analyses of Evolutionary Diversification of the Endo 16 Promoter awarded by National Aeronautics and Space Administration 1999 - 2002
- Doctoral Dissertation: The Evolutionary and Developmental Genetic Basis of Wing Polymorphisms in Ants awarded by National Science Foundation 2000 - 2002
- Molecular bases for the evolution of new developmental roles in two homeobox genes awarded by National Science Foundation 2000 - 2001
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Davidson, Phillip L., Haobing Guo, Jane S. Swart, Abdull J. Massri, Allison Edgar, Lingyu Wang, Alejandro Berrio, et al. “Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins.” Nature Ecology & Evolution 6, no. 12 (December 2022): 1907–20. https://doi.org/10.1038/s41559-022-01906-9.Full Text
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Ketchum, Remi N., Phillip L. Davidson, Edward G. Smith, Gregory A. Wray, John A. Burt, Joseph F. Ryan, and Adam M. Reitzel. “A Chromosome-level Genome Assembly of the Highly Heterozygous Sea Urchin Echinometra sp. EZ Reveals Adaptation in the Regulatory Regions of Stress Response Genes.” Genome Biology and Evolution 14, no. 10 (October 2022): evac144. https://doi.org/10.1093/gbe/evac144.Full Text
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Davidson, Phillip L., Maria Byrne, and Gregory A. Wray. “Evolutionary Changes in the Chromatin Landscape Contribute to Reorganization of a Developmental Gene Network During Rapid Life History Evolution in Sea Urchins.” Molecular Biology and Evolution 39, no. 9 (September 2022): msac172. https://doi.org/10.1093/molbev/msac172.Full Text
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Byrne, Maria, Demian Koop, Dario Strbenac, Paula Cisternas, Jean Yee Hwa Yang, Phillip L. Davidson, and Gregory Wray. “Transcriptomic analysis of Nodal - and BMP- associated genes during development to the juvenile seastar in Parvulastra exigua (Asterinidae).” Marine Genomics 59 (October 2021): 100857. https://doi.org/10.1016/j.margen.2021.100857.Full Text
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Massri, Abdull J., Laura Greenstreet, Anton Afanassiev, Alejandro Berrio, Gregory A. Wray, Geoffrey Schiebinger, and David R. McClay. “Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo.” Development (Cambridge, England) 148, no. 19 (October 2021): dev198614. https://doi.org/10.1242/dev.198614.Full Text Open Access Copy
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Brazeau, Nicholas F., Cedar L. Mitchell, Andrew P. Morgan, Molly Deutsch-Feldman, Oliver John Watson, Kyaw L. Thwai, Pere Gelabert, et al. “The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo.” Nature Communications 12, no. 1 (July 2021): 4169. https://doi.org/10.1038/s41467-021-24216-3.Full Text
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Hu, Benxia, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, et al. “Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.” Nat Commun 12, no. 1 (June 25, 2021): 3968. https://doi.org/10.1038/s41467-021-24243-0.Full Text Link to Item
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Benito-Kwiecinski, Silvia, Stefano L. Giandomenico, Magdalena Sutcliffe, Erlend S. Riis, Paula Freire-Pritchett, Iva Kelava, Stephanie Wunderlich, et al. “An early cell shape transition drives evolutionary expansion of the human forebrain.” Cell 184, no. 8 (April 2021): 2084-2102.e19. https://doi.org/10.1016/j.cell.2021.02.050.Full Text
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Carrier, Tyler J., Brittany A. Leigh, Dione J. Deaker, Hannah R. Devens, Gregory A. Wray, Seth R. Bordenstein, Maria Byrne, and Adam M. Reitzel. “Microbiome reduction and endosymbiont gain from a switch in sea urchin life history.” Proceedings of the National Academy of Sciences of the United States of America 118, no. 16 (April 2021): e2022023118. https://doi.org/10.1073/pnas.2022023118.Full Text
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Markunas, Alexandra M., Perathu K. R. Manivannan, Jordan E. Ezekian, Agnim Agarwal, William Eisner, Katherina Alsina, Hugh D. Allen, et al. “TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death.” Am J Med Genet A 185, no. 3 (March 2021): 923–29. https://doi.org/10.1002/ajmg.a.62037.Full Text Open Access Copy Link to Item
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Massri, Abdull J., Geoffrey R. Schiebinger, Alejandro Berrio, Lingyu Wang, Gregory A. Wray, and David R. McClay. “Methodologies for Following EMT In Vivo at Single Cell Resolution.” Methods in Molecular Biology (Clifton, N.J.) 2179 (January 2021): 303–14. https://doi.org/10.1007/978-1-0716-0779-4_23.Full Text
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Song, Hao, Ximing Guo, Lina Sun, Qianghui Wang, Fengming Han, Haiyan Wang, Gregory A. Wray, et al. “The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia.” Bmc Biology 19, no. 1 (January 2021): 15. https://doi.org/10.1186/s12915-020-00943-9.Full Text
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Devens, Hannah R., Phillip L. Davidson, Dione J. Deaker, Kathryn E. Smith, Gregory A. Wray, and Maria Byrne. “Ocean acidification induces distinct transcriptomic responses across life history stages of the sea urchin Heliocidaris erythrogramma.” Molecular Ecology 29, no. 23 (December 2020): 4618–36. https://doi.org/10.1111/mec.15664.Full Text
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Davidson, Phillip L., Haobing Guo, Lingyu Wang, Alejandro Berrio, He Zhang, Yue Chang, Andrew L. Soborowski, David R. McClay, Guangyi Fan, and Gregory A. Wray. “Chromosomal-Level Genome Assembly of the Sea Urchin Lytechinus variegatus Substantially Improves Functional Genomic Analyses.” Genome Biology and Evolution 12, no. 7 (July 2020): 1080–86. https://doi.org/10.1093/gbe/evaa101.Full Text
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Wang, Lingyu, Jennifer W. Israel, Allison Edgar, Rudolf A. Raff, Elizabeth C. Raff, Maria Byrne, and Gregory A. Wray. “Genetic basis for divergence in developmental gene expression in two closely related sea urchins.” Nature Ecology & Evolution 4, no. 6 (June 2020): 831–40. https://doi.org/10.1038/s41559-020-1165-y.Full Text
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Berrio, Alejandro, Ralph Haygood, and Gregory A. Wray. “Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral.” Bmc Genomics 21, no. 1 (May 2020): 359. https://doi.org/10.1186/s12864-020-6752-4.Full Text Open Access Copy
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Muley, Vijaykumar Yogesh, Carlos Javier López-Victorio, Jorge Tonatiuh Ayala-Sumuano, Adriana González-Gallardo, Leopoldo González-Santos, Carlos Lozano-Flores, Gregory Wray, Maribel Hernández-Rosales, and Alfredo Varela-Echavarría. “Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos.” Progress in Neurobiology 186 (March 2020): 101735. https://doi.org/10.1016/j.pneurobio.2019.101735.Full Text
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Byrne, Maria, Demian Koop, Dario Strbenac, Paula Cisternas, Regina Balogh, Jean Yee Hwa Yang, Phillip L. Davidson, and Gregory Wray. “Transcriptomic analysis of sea star development through metamorphosis to the highly derived pentameral body plan with a focus on neural transcription factors.” Dna Research : An International Journal for Rapid Publication of Reports on Genes and Genomes 27, no. 1 (February 2020): dsaa007. https://doi.org/10.1093/dnares/dsaa007.Full Text
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Berrio, Alejandro, Valerie Gartner, and Gregory A. Wray. “Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function.” Peerj 8 (January 2020): e10234. https://doi.org/10.7717/peerj.10234.Full Text Open Access Copy
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Berrio, Alejandro, Valerie Gartner, and Gregory Wray. “Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function,” 2020. https://doi.org/10.1101/2020.09.16.300038.Full Text Open Access Copy
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Edsall, Lee E., Alejandro Berrio, William H. Majoros, Devjanee Swain-Lenz, Shauna Morrow, Yoichiro Shibata, Alexias Safi, Gregory A. Wray, Gregory E. Crawford, and Andrew S. Allen. “Evaluating Chromatin Accessibility Differences Across Multiple Primate Species Using a Joint Modeling Approach.” Genome Biol Evol 11, no. 10 (October 1, 2019): 3035–53. https://doi.org/10.1093/gbe/evz218.Full Text Link to Item
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Davidson, Phillip L., J Will Thompson, Matthew W. Foster, M Arthur Moseley, Maria Byrne, and Gregory A. Wray. “A comparative analysis of egg provisioning using mass spectrometry during rapid life history evolution in sea urchins.” Evol Dev 21, no. 4 (July 2019): 188–204. https://doi.org/10.1111/ede.12289.Full Text Open Access Copy Link to Item
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Swain-Lenz, Devjanee, Alejandro Berrio, Alexias Safi, Gregory E. Crawford, and Gregory A. Wray. “Comparative Analyses of Chromatin Landscape in White Adipose Tissue Suggest Humans May Have Less Beigeing Potential than Other Primates.” Genome Biol Evol 11, no. 7 (July 1, 2019): 1997–2008. https://doi.org/10.1093/gbe/evz134.Full Text Link to Item
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Wray, Gregory A., and Eric S. Haag. “Rudolf A. Raff (1941-2019).” Nature Ecology & Evolution 3, no. 4 (April 2019): 518–19. https://doi.org/10.1038/s41559-019-0844-z.Full Text
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Edgar, Allison, Maria Byrne, and Gregory A. Wray. “Embryo microinjection of the lecithotrophic sea urchin Heliocidaris erythrogramma.” Journal of Biological Methods 6, no. 3 (January 2019): e119. https://doi.org/10.14440/jbm.2019.292.Full Text Open Access Copy
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Edgar, Allison, Maria Byrne, David McClay, and Gregory Wray. “Evolution of abbreviated development inHeliocidaris erythrogrammadramatically re-wired the highly conserved sea urchin developmental gene regulatory network to decouple signaling center function from ultimate fate,” 2019. https://doi.org/10.1101/712216.Full Text
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Oulhen, Nathalie, Stephany Foster, Greg Wray, and Gary Wessel. “Identifying gene expression from single cells to single genes.” Methods in Cell Biology 151 (January 2019): 127–58. https://doi.org/10.1016/bs.mcb.2018.11.018.Full Text
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Swain-Lenz, Devjanee, Alejandro Berrio, Alexias Safi, Gregory Crawford, and Gregory Wray. “Comparative analyses of chromatin landscape in white adipose tissue suggest humans may have less beigeing potential than other primates,” 2019. https://doi.org/10.1101/524868.Full Text
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Li, Mingfeng, Gabriel Santpere, Yuka Imamura Kawasawa, Oleg V. Evgrafov, Forrest O. Gulden, Sirisha Pochareddy, Susan M. Sunkin, et al. “Integrative functional genomic analysis of human brain development and neuropsychiatric risks.” Science 362, no. 6420 (December 14, 2018). https://doi.org/10.1126/science.aat7615.Full Text Link to Item
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Eisthen, Heather L., Kenneth M. Halanych, Darcy B. Kelley, Stephanie A. White, Steven M. Phelps, and Steven M. 66 additional authors. “New NSF policy will stifle innovation.” Science (New York, N.Y.) 362, no. 6412 (October 2018): 297–98. https://doi.org/10.1126/science.aav4793.Full Text
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Bryois, Julien, Melanie E. Garrett, Lingyun Song, Alexias Safi, Paola Giusti-Rodriguez, Graham D. Johnson, Annie W. Shieh, et al. “Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia.” Nat Commun 9, no. 1 (August 7, 2018): 3121. https://doi.org/10.1038/s41467-018-05379-y.Full Text Link to Item
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Pizzollo, Jason, William J. Nielsen, Yoichiro Shibata, Alexias Safi, Gregory E. Crawford, Gregory A. Wray, and Courtney C. Babbitt. “Comparative Serum Challenges Show Divergent Patterns of Gene Expression and Open Chromatin in Human and Chimpanzee.” Genome Biol Evol 10, no. 3 (March 1, 2018): 826–39. https://doi.org/10.1093/gbe/evy041.Full Text Open Access Copy Link to Item
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Byrne, Maria, Demian Koop, Valerie B. Morris, Juanita Chui, Gregory A. Wray, and Paula Cisternas. “Expression of genes and proteins of the pax-six-eya-dach network in the metamorphic sea urchin: Insights into development of the enigmatic echinoderm body plan and sensory structures.” Developmental Dynamics : An Official Publication of the American Association of Anatomists 247, no. 1 (January 2018): 239–49. https://doi.org/10.1002/dvdy.24584.Full Text
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Singh, A., L. Pinto, C. Martin, N. Rutherford, A. Ragunathan, U. Upadhyay, P. Kapoor, et al. “Rudiment resorption as a response to starvation during larval development in the sea urchin Strongylocentrotus droebachiensis.” Canadian Journal of Zoology 96, no. 10 (January 1, 2018): 1178–85. https://doi.org/10.1139/cjz-2017-0261.Full Text
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Linchangco, Gregorio V., David W. Foltz, Rob Reid, John Williams, Conor Nodzak, Alexander M. Kerr, Allison K. Miller, et al. “The phylogeny of extant starfish (Asteroidea: Echinodermata) including Xyloplax, based on comparative transcriptomics.” Molecular Phylogenetics and Evolution 115 (October 2017): 161–70. https://doi.org/10.1016/j.ympev.2017.07.022.Full Text Open Access Copy
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Babbitt, Courtney C., Ralph Haygood, William J. Nielsen, and Gregory A. Wray. “Gene expression and adaptive noncoding changes during human evolution.” Bmc Genomics 18, no. 1 (June 2017): 435. https://doi.org/10.1186/s12864-017-3831-2.Full Text
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Koop, Demian, Paula Cisternas, Valerie B. Morris, Dario Strbenac, Jean Yee Hwa Yang, Gregory A. Wray, and Maria Byrne. “Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan.” Bmc Developmental Biology 17, no. 1 (February 13, 2017): 4. https://doi.org/10.1186/s12861-017-0145-1.Full Text
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Runcie, Daniel E., Narimane Dorey, David A. Garfield, Meike Stumpp, Sam Dupont, and Gregory A. Wray. “Genomic Characterization of the Evolutionary Potential of the Sea Urchin Strongylocentrotus droebachiensis Facing Ocean Acidification.” Genome Biology and Evolution 8, no. 12 (December 2016): 3672–84. https://doi.org/10.1093/gbe/evw272.Full Text Open Access Copy
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Dutta, Vikrant, Eric Altermann, Jonathan Olson, Gregory Allan Wray, Robin M. Siletzky, and Sophia Kathariou. “Whole-Genome Sequences of Agricultural, Host-Associated Campylobacter coli and Campylobacter jejuni Strains.” Genome Announcements 4, no. 4 (August 2016): e00833–e00816. https://doi.org/10.1128/genomea.00833-16.Full Text
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Israel, Jennifer W., Megan L. Martik, Maria Byrne, Elizabeth C. Raff, Rudolf A. Raff, David R. McClay, and Gregory A. Wray. “Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris.” Plos Biology 14, no. 3 (March 2016): e1002391. https://doi.org/10.1371/journal.pbio.1002391.Full Text
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Schierwater, B., P. W. H. Holland, D. J. Miller, P. F. Stadler, B. M. Wiegmann, G. Wörheide, G. A. Wray, and R. DeSalle. “Never ending analysis of a century old evolutionary debate: "Unringing" the urmetazoon bell.” Frontiers in Ecology and Evolution 4, no. FEB (February 4, 2016). https://doi.org/10.3389/fevo.2016.00005.Full Text
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Janies, Daniel A., Zach Witter, Gregorio V. Linchangco, David W. Foltz, Allison K. Miller, Alexander M. Kerr, Jeremy Jay, Robert W. Reid, and Gregory A. Wray. “EchinoDB, an application for comparative transcriptomics of deeply-sampled clades of echinoderms.” Bmc Bioinformatics 17 (January 2016): 48. https://doi.org/10.1186/s12859-016-0883-2.Full Text Open Access Copy
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Byrne, Maria, Demian Koop, Paula Cisternas, Dario Strbenac, Jean Yee Hwa Yang, and Gregory A. Wray. “Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma.” Marine Genomics 24 Pt 1 (December 2015): 41–45. https://doi.org/10.1016/j.margen.2015.05.019.Full Text
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PsychENCODE Consortium, Nenad, Schahram Akbarian, Chunyu Liu, James A. Knowles, Flora M. Vaccarino, Peggy J. Farnham, Gregory E. Crawford, et al. “The PsychENCODE project.” Nat Neurosci 18, no. 12 (December 2015): 1707–12. https://doi.org/10.1038/nn.4156.Full Text Open Access Copy Link to Item
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Wray, Gregory A. “Molecular clocks and the early evolution of metazoan nervous systems.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 370, no. 1684 (December 2015): 20150046. https://doi.org/10.1098/rstb.2015.0046.Full Text
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Bauernfeind, Amy L., Michelle L. Reyzer, Richard M. Caprioli, John J. Ely, Courtney C. Babbitt, Gregory A. Wray, Patrick R. Hof, and Chet C. Sherwood. “High spatial resolution proteomic comparison of the brain in humans and chimpanzees.” The Journal of Comparative Neurology 523, no. 14 (October 2015): 2043–61. https://doi.org/10.1002/cne.23777.Full Text
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Bauernfeind, Amy L., Erik J. Soderblom, Meredith E. Turner, M Arthur Moseley, John J. Ely, Patrick R. Hof, Chet C. Sherwood, Gregory A. Wray, and Courtney C. Babbitt. “Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees.” Genome Biol Evol 7, no. 8 (July 10, 2015): 2276–88. https://doi.org/10.1093/gbe/evv132.Full Text Open Access Copy Link to Item
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Muntané, Gerard, Julie E. Horvath, Patrick R. Hof, John J. Ely, William D. Hopkins, Mary Ann Raghanti, Albert H. Lewandowski, Gregory A. Wray, and Chet C. Sherwood. “Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission.” Cerebral Cortex (New York, N.Y. : 1991) 25, no. 6 (June 2015): 1596–1607. https://doi.org/10.1093/cercor/bht354.Full Text
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Boyd, J Lomax, Stephanie L. Skove, Jeremy P. Rouanet, Louis-Jan Pilaz, Tristan Bepler, Raluca Gordân, Gregory A. Wray, and Debra L. Silver. “Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.” Curr Biol 25, no. 6 (March 16, 2015): 772–79. https://doi.org/10.1016/j.cub.2015.01.041.Full Text Open Access Copy Link to Item
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Wray, Gregory A., Hopi E. Hoekstra, Douglas J. Futuyma, Richard E. Lenski, Trudy F. C. Mackay, Dolph Schluter, and Joan E. Strassmann. “Does evolutionary theory need a rethink? - COUNTERPOINT No, all is well.” Nature 514, no. 7521 (October 9, 2014): 161-+.Open Access Copy Link to Item
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Laland, Kevin, Tobias Uller, Marc Feldman, Kim Sterelny, Gerd B. Müller, Armin Moczek, Eva Jablonka, et al. “Does evolutionary theory need a rethink?” Nature 514, no. 7521 (October 2014): 161–64. https://doi.org/10.1038/514161a.Full Text
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Horvath, Julie E., Gowri L. Ramachandran, Olivier Fedrigo, William J. Nielsen, Courtney C. Babbitt, Elizabeth M. St Clair, Lisa W. Pfefferle, Jukka Jernvall, Gregory A. Wray, and Christine E. Wall. “Genetic comparisons yield insight into the evolution of enamel thickness during human evolution.” Journal of Human Evolution 73 (August 2014): 75–87. https://doi.org/10.1016/j.jhevol.2014.01.005.Full Text
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Liu, Shiping, Eline D. Lorenzen, Matteo Fumagalli, Bo Li, Kelley Harris, Zijun Xiong, Long Zhou, et al. “Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears.” Cell 157, no. 4 (May 2014): 785–94. https://doi.org/10.1016/j.cell.2014.03.054.Full Text
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Wygoda, Jennifer A., Yee Yang, Maria Byrne, and Gregory A. Wray. “Transcriptomic analysis of the highly derived radial body plan of a sea urchin.” Genome Biology and Evolution 6, no. 4 (April 2014): 964–73. https://doi.org/10.1093/gbe/evu070.Full Text
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Ganapathy, Ganeshkumar, Jason T. Howard, James M. Ward, Jianwen Li, Bo Li, Yingrui Li, Yingqi Xiong, et al. “High-coverage sequencing and annotated assemblies of the budgerigar genome.” Gigascience 3 (2014): 11. https://doi.org/10.1186/2047-217X-3-11.Full Text Open Access Copy Link to Item
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Garfield, David A., Daniel E. Runcie, Courtney C. Babbitt, Ralph Haygood, William J. Nielsen, and Gregory A. Wray. “The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network.” Plos Biology 11, no. 10 (October 2013): e1001696. https://doi.org/10.1371/journal.pbio.1001696.Full Text
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Runcie, Daniel E., Ralph T. Wiedmann, Elizabeth A. Archie, Jeanne Altmann, Gregory A. Wray, Susan C. Alberts, and Jenny Tung. “Social environment influences the relationship between genotype and gene expression in wild baboons.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 368, no. 1618 (May 2013): 20120345. https://doi.org/10.1098/rstb.2012.0345.Full Text
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Pfefferle, Lisa W., and Gregory A. Wray. “Insights from a chimpanzee adipose stromal cell population: opportunities for adult stem cells to expand primate functional genomics.” Genome Biology and Evolution 5, no. 10 (January 2013): 1995–2005. https://doi.org/10.1093/gbe/evt148.Full Text
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Wray, G. A. “Genomics and the evolution of phenotypic traits.” Annual Review of Ecology, Evolution, and Systematics 44 (January 1, 2013): 51–72. https://doi.org/10.1146/annurev-ecolsys-110512-135828.Full Text
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Runcie, Daniel E., David A. Garfield, Courtney C. Babbitt, Jennifer A. Wygoda, Sayan Mukherjee, and Gregory A. Wray. “Genetics of gene expression responses to temperature stress in a sea urchin gene network.” Molecular Ecology 21, no. 18 (September 2012): 4547–62. https://doi.org/10.1111/j.1365-294x.2012.05717.x.Full Text
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Shibata, Yoichiro, Nathan C. Sheffield, Olivier Fedrigo, Courtney C. Babbitt, Matthew Wortham, Alok K. Tewari, Darin London, et al. “Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.” Plos Genet 8, no. 6 (June 2012): e1002789. https://doi.org/10.1371/journal.pgen.1002789.Full Text Link to Item
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Garfield, David, Ralph Haygood, William J. Nielsen, and Gregory A. Wray. “Population genetics of cis-regulatory sequences that operate during embryonic development in the sea urchin Strongylocentrotus purpuratus.” Evolution & Development 14, no. 2 (March 2012): 152–67. https://doi.org/10.1111/j.1525-142x.2012.00532.x.Full Text
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Babbitt, Courtney C., Jenny Tung, Gregory A. Wray, and Susan C. Alberts. “Changes in gene expression associated with reproductive maturation in wild female baboons.” Genome Biology and Evolution 4, no. 2 (January 2012): 102–9. https://doi.org/10.1093/gbe/evr134.Full Text
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Smith, M. S., G. A. Wray, and R. A. Raff. “Revisiting cell lineage and cell fate in light of the evolution of axis formation in Heliocidaris erythrogramma (Accepted).” Evolution & Development, 2012.
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Bilbo, Staci D., Gregory A. Wray, Sarah E. Perkins, and William Parker. “Reconstitution of the human biome as the most reasonable solution for epidemics of allergic and autoimmune diseases.” Med Hypotheses 77, no. 4 (October 2011): 494–504. https://doi.org/10.1016/j.mehy.2011.06.019.Full Text Link to Item
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Wray, Gregory A. “Evolution. CNCing is believing.” Science (New York, N.Y.) 333, no. 6045 (August 2011): 946–47. https://doi.org/10.1126/science.1210771.Full Text
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Babbitt, Courtney C., Lisa R. Warner, Olivier Fedrigo, Christine E. Wall, and Gregory A. Wray. “Genomic signatures of diet-related shifts during human origins.” Proceedings. Biological Sciences 278, no. 1708 (April 2011): 961–69. https://doi.org/10.1098/rspb.2010.2433.Full Text
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Pfefferle, Adam D., Lisa R. Warner, Catrina W. Wang, William J. Nielsen, Courtney C. Babbitt, Olivier Fedrigo, and Gregory A. Wray. “Comparative expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution.” Journal of Human Evolution 60, no. 2 (February 2011): 205–12. https://doi.org/10.1016/j.jhevol.2010.10.004.Full Text
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Tung, J., M. Y. Akinyi, S. Mutura, J. Altmann, G. A. Wray, and S. C. Alberts. “Allele-specific gene expression in a wild nonhuman primate population.” Molecular Ecology 20, no. 4 (February 2011): 725–39. https://doi.org/10.1111/j.1365-294x.2010.04970.x.Full Text
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Babbitt, C. C., L. R. Warner, O. Fedrigo, C. E. Wall, and G. A. Wray. “Genomic signatures of diet-related shifts in primate evolution.” Proceedings of the Royal Society of London B 278 (2011): 961–69.
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Fedrigo, O., A. D. Pfefferele, C. C. Babbitt, R. Haygood, C. E. Wall, and G. A. Wray. “Molecular evidence that a metabolic trade-off contributed to human brain size evolution.” Brain, Behavior, and Evolution 78 (2011): 315–26.
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Fedrigo, Olivier, Adam D. Pfefferle, Courtney C. Babbitt, Ralph Haygood, Christine E. Wall, and Gregory A. Wray. “A potential role for glucose transporters in the evolution of human brain size.” Brain, Behavior and Evolution 78, no. 4 (January 2011): 315–26. https://doi.org/10.1159/000329852.Full Text
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Pfefferle, A. D., L. R. Warner, C. W. Wang, W. J. Nielsen, C. C. Babbitt, O. Fedrigo, and G. A. Wray. “Expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution.” Journal for Human Evolution 60 (2011): 205–11.
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Szövényi, Péter, Stefan A. Rensing, Daniel Lang, Gregory A. Wray, and A Jonathan Shaw. “Generation-biased gene expression in a bryophyte model system.” Molecular Biology and Evolution 28, no. 1 (January 2011): 803–12. https://doi.org/10.1093/molbev/msq254.Full Text
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Yokoyama, K. D., J. L. Thorne, and G. A. Wray. “Coordinated genome-wide modifications within proximal promoter cis-regulatory elements during vertebrate evolution.” Genome Biology and Evolution 3 (2011): 66–74.
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Tung, Jenny, Susan C. Alberts, and Gregory A. Wray. “Evolutionary genetics in wild primates: combining genetic approaches with field studies of natural populations.” Trends in Genetics : Tig 26, no. 8 (August 2010): 353–62. https://doi.org/10.1016/j.tig.2010.05.005.Full Text
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Haygood, Ralph, Courtney C. Babbitt, Olivier Fedrigo, and Gregory A. Wray. “Contrasts between adaptive coding and noncoding changes during human evolution.” Proceedings of the National Academy of Sciences of the United States of America 107, no. 17 (April 2010): 7853–57. https://doi.org/10.1073/pnas.0911249107.Full Text
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Babbitt, Courtney C., Jesse S. Silverman, Ralph Haygood, Jennifer M. Reininga, Matthew V. Rockman, and Gregory A. Wray. “Multiple Functional Variants in cis Modulate PDYN Expression.” Molecular Biology and Evolution 27, no. 2 (February 2010): 465–79. https://doi.org/10.1093/molbev/msp276.Full Text
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Cruz-Gordillo, Peter, Olivier Fedrigo, Gregory A. Wray, and Courtney C. Babbitt. “Extensive changes in the expression of the opioid genes between humans and chimpanzees.” Brain, Behavior and Evolution 76, no. 2 (January 2010): 154–62. https://doi.org/10.1159/000320968.Full Text
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Fedrigo, O., L. R. Warner, A. D. Pfefferle, C. C. Babbitt, P. Cruz-Gordillo, and G. A. Wray. “A pipeline to determine RT-QPCR control genes for evolutionary studies: Application to primate gene expression across multiple tissues.” Plos One 5, no. 9 (2010): 1–7. https://doi.org/10.1371/journal.pone.0012545.Full Text
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Fedrigo, O., L. R. Warner, A. D. Pfefferle, P. Cruz Gordillo, C. C. Babbitt, and G. A. Wray. “A pipeline to determine RT-PCR control genes for evolutionary studies: application to primate gene expression across multiple tissues.” Plos One 5 (2010): E12545.Open Access Copy
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Fédrigo, Olivier, and Gregory A. Wray. “Developmental evolution: how beetles evolved their shields.” Current Biology : Cb 20, no. 2 (January 2010): R64–66. https://doi.org/10.1016/j.cub.2009.12.012.Full Text
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Garfield, D. A., and G. A. Wray. “The evolution of gene regulatory interactions.” Bioscience 60, no. 1 (January 1, 2010): 15–23. https://doi.org/10.1525/bio.2010.60.1.6.Full Text
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Oliver, Thomas A., David A. Garfield, Mollie K. Manier, Ralph Haygood, Gregory A. Wray, and Stephen R. Palumbi. “Whole-genome positive selection and habitat-driven evolution in a shallow and a deep-sea urchin.” Genome Biology and Evolution 2 (January 2010): 800–814. https://doi.org/10.1093/gbe/evq063.Full Text
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Babbitt, Courtney C., Olivier Fedrigo, Adam D. Pfefferle, Alan P. Boyle, Julie E. Horvath, Terrence S. Furey, and Gregory A. Wray. “Both noncoding and protein-coding RNAs contribute to gene expression evolution in the primate brain.” Genome Biology and Evolution 2 (January 2010): 67–79. https://doi.org/10.1093/gbe/evq002.Full Text
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Tung, Jenny, Olivier Fédrigo, Ralph Haygood, Sayan Mukherjee, and Gregory A. Wray. “Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation.” Molecular Biology and Evolution 26, no. 9 (September 2009): 2047–59. https://doi.org/10.1093/molbev/msp113.Full Text
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Tung, Jenny, Alexander Primus, Andrew J. Bouley, Tonya F. Severson, Susan C. Alberts, and Gregory A. Wray. “Evolution of a malaria resistance gene in wild primates.” Nature 460, no. 7253 (July 2009): 388–91. https://doi.org/10.1038/nature08149.Full Text
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Yokoyama, Ken Daigoro, Uwe Ohler, and Gregory A. Wray. “Measuring spatial preferences at fine-scale resolution identifies known and novel cis-regulatory element candidates and functional motif-pair relationships.” Nucleic Acids Res 37, no. 13 (July 2009): e92. https://doi.org/10.1093/nar/gkp423.Full Text Link to Item
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Garfield, David A., and Gregory A. Wray. “Comparative embryology without a microscope: using genomic approaches to understand the evolution of development.” Journal of Biology 8, no. 7 (January 2009): 65. https://doi.org/10.1186/jbiol161.Full Text
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Yokoyama, K. D., U. Ohler, and G. A. Wray. “Spatial preferences identify known and novel cis-regulatory element candidates and functional motif-pair relationships.” Nucleic Acids Research 37 (2009): e92.
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Warner, L. R., C. C. Babbitt, A. E. Primus, T. F. Severson, R. Haygood, and G. A. Wray. “The functional consequences of genetic variation on tyrosine hydroxylase (TH) expression.” Brain Research 1288 (2009): 1–8.
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Haygood, R., O. Fedrigo, and G. A. Wray. “Reply to "Rapidly evolving human promoter regions".” Nature Genetics 40, no. 11 (November 1, 2008): 1263–64. https://doi.org/10.1038/ng1108-1263.Full Text
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Wray, Gregory A., and Courtney C. Babbitt. “Genetics. Enhancing gene regulation.” Science (New York, N.Y.) 321, no. 5894 (September 2008): 1300–1301. https://doi.org/10.1126/science.1163568.Full Text
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Horvath, Julie E., David W. Weisrock, Stephanie L. Embry, Isabella Fiorentino, James P. Balhoff, Peter Kappeler, Gregory A. Wray, Huntington F. Willard, and Anne D. Yoder. “Development and application of a phylogenomic toolkit: resolving the evolutionary history of Madagascar's lemurs.” Genome Research 18, no. 3 (March 2008): 489–99. https://doi.org/10.1101/gr.7265208.Full Text
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Mitchell-Olds, T., M. Feder, and G. Wray. “Evolutionary and ecological functional genomics.” Heredity 100, no. 2 (February 2008): 101–2. https://doi.org/10.1038/sj.hdy.6801015.Full Text
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Wray, G. A., and C. C. Babbitt. “Enhancing gene regulation.” Science 321 (2008): 1300–1301.
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Bowsher, Julia H., Gregory A. Wray, and Ehab Abouheif. “Growth and patterning are evolutionarily dissociated in the vestigial wing discs of workers of the red imported fire ant, Solenopsis invicta.” Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution 308, no. 6 (December 2007): 769–76. https://doi.org/10.1002/jez.b.21200.Full Text
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Sumrall, C. D., and G. A. Wray. “Ontogeny in the fossil record: Diversification of body plans and the evolution of "aberrant" symmetry in Paleozoic echinoderms.” Paleobiology 33, no. 1 (December 1, 2007): 149–63. https://doi.org/10.1666/06053.1.Full Text
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Babbitt, Courtney C., Ralph Haygood, and Gregory A. Wray. “When two is better than one.” Cell 131, no. 2 (October 2007): 225–27. https://doi.org/10.1016/j.cell.2007.10.001.Full Text
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Wray, Gregory A. “The evolutionary significance of cis-regulatory mutations.” Nature Reviews. Genetics 8, no. 3 (March 2007): 206–16. https://doi.org/10.1038/nrg2063.Full Text
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Tishkoff, G. A., S. A, F. A. Reed, A. Ranciaro, B. F. Voight, C. C. Babbitt, J. S. Silverman, et al. “Convergent adaptation in humans: the genetic basis of lactase persistence in Africa.” Nature Genetics 39 (2007): 31–40.
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Tishkoff, Sarah A., Floyd A. Reed, Alessia Ranciaro, Benjamin F. Voight, Courtney C. Babbitt, Jesse S. Silverman, Kweli Powell, et al. “Convergent adaptation of human lactase persistence in Africa and Europe.” Nature Genetics 39, no. 1 (January 2007): 31–40. https://doi.org/10.1038/ng1946.Full Text
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Babbitt, P., P. CC, R. Haygood, and G. A. Wray. “When two is better than one.” Cell 19 (2007): 3–4.
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Haygood, K. A., K. A. R, O. Fedrigo, B. Hanson, K. -. D. Yokoyama, and G. A. Wray. “Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution.” Nature Genetics 39 (2007): 1140–44.
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Nyberg, K. G., C. N. Ciampaglio, and G. A. Wray. “Tracing the ancestry of the great white shark, Carcharodon carcharias, using morphometric analyses of fossil teeth.” Journal of Vertebrate Paleontology 26, no. 4 (December 11, 2006): 806–14. https://doi.org/10.1671/0272-4634(2006)26[806:TTAOTG]2.0.CO;2.Full Text
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Babbitt, Courtney C., and Greogory A. Wray. “Functional analysis of cis-regulatory evolution in humans and other primates.” Integrative and Comparative Biology 46 (December 1, 2006): E6–E6.Link to Item
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Romano, Laura A., and Gregory A. Wray. “Endo16 is required for gastrulation in the sea urchin Lytechinus variegatus.” Development, Growth & Differentiation 48, no. 8 (October 2006): 487–97. https://doi.org/10.1111/j.1440-169x.2006.00884.x.Full Text
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Loisel, Dagan A., Matthew V. Rockman, Gregory A. Wray, Jeanne Altmann, and Susan C. Alberts. “Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region.” Proceedings of the National Academy of Sciences of the United States of America 103, no. 44 (October 2006): 16331–36. https://doi.org/10.1073/pnas.0607662103.Full Text
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Wray, Gregory A. “The evolution of embryonic gene expression in sea urchins.” Integrative and Comparative Biology 46, no. 3 (June 2006): 233–42. https://doi.org/10.1093/icb/icj030.Full Text
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Wray, Gregory A. “Evolution: spot on (and off).” Nature 440, no. 7087 (April 2006): 1001–2. https://doi.org/10.1038/4401001a.Full Text
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Rudd, M Katharine, Gregory A. Wray, and Huntington F. Willard. “The evolutionary dynamics of alpha-satellite.” Genome Research 16, no. 1 (January 2006): 88–96. https://doi.org/10.1101/gr.3810906.Full Text
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Sumrall, C. D., and G. A. Wray. “Developmental control of ambulacral reduction in fossil echinoderms.” Paleobiology 33 (2006): 149–63.
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Wray, G. A. “Spot on (and off).” Nature 440 (2006): 1001–2.
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Sodergren, J., J. E, G. M. Weinstock, and The Sea Urchin Genome Sequencing Consortium. “The genome of the sea urchin Stongylocentrotus purpuratus.” Science 314 (2006): 941–52.
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Rockman, M. V., M. W. Hahn, N. Soranzo, F. Zimprich, D. B. Goldstein, and G. A. Wray. “Ancient and recent positive selection transformed opioid cis-regulation in humans.” Plos Biology 3, no. 12 (December 1, 2005).
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Rockman, Matthew V., Matthew W. Hahn, Nicole Soranzo, Fritz Zimprich, David B. Goldstein, and Gregory A. Wray. “Ancient and recent positive selection transformed opioid cis-regulation in humans.” Plos Biology 3, no. 12 (December 2005): e387. https://doi.org/10.1371/journal.pbio.0030387.Full Text
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Mooi, Rich, Bruno David, and Gregory A. Wray. “Arrays in rays: terminal addition in echinoderms and its correlation with gene expression.” Evolution & Development 7, no. 6 (November 2005): 542–55. https://doi.org/10.1111/j.1525-142x.2005.05058.x.Full Text
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Balhoff, James P., and Gregory A. Wray. “Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites.” Proceedings of the National Academy of Sciences of the United States of America 102, no. 24 (June 2005): 8591–96. https://doi.org/10.1073/pnas.0409638102.Full Text
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Rockman, Matthew V., Matthew W. Hahn, Nicole Soranzo, Dagan A. Loisel, David B. Goldstein, and Gregory A. Wray. “Positive selection on MMP3 regulation has shaped heart disease risk.” Current Biology : Cb 14, no. 17 (September 2004): 1531–39. https://doi.org/10.1016/j.cub.2004.08.051.Full Text
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Hahn, Matthew W., Matthew V. Rockman, Nicole Soranzo, David B. Goldstein, and Gregory A. Wray. “Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans.” Genetics 167, no. 2 (June 2004): 867–77. https://doi.org/10.1534/genetics.103.025726.Full Text
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Bely, A. E., and G. A. Wray. “Molecular phylogeny of naidid worms (Annelida: Clitellata).” Molecular Phylogeny and Evolution 30 (2004): 50–63.
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Bely, Alexandra E., and Gregory A. Wray. “Molecular phylogeny of naidid worms (Annelida: Clitellata) based on cytochrome oxidase I.” Molecular Phylogenetics and Evolution 30, no. 1 (January 2004): 50–63. https://doi.org/10.1016/s1055-7903(03)00180-5.Full Text
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Ettensohn, Charles A., Gary M. Wessel, and Gregory A. Wray. “The invertebrate deuterostomes: an introduction to their phylogeny, reproduction, development, and genomics.” Methods in Cell Biology 74 (January 2004): 1–13. https://doi.org/10.1016/s0091-679x(04)74001-7.Full Text
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Levinton, J., L. Dubb, and G. A. Wray. “Simulations of evolutionary radiations and their application to understanding the probability of a Cambrian explosion.” Journal of Paleontology 78, no. 1 (January 1, 2004): 31–38. https://doi.org/10.1666/0022-3360(2004)078<0031:SOERAT>2.0.CO;2.Full Text
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Wray, Gregory A., Chisato Kitazawa, and Benjamin Miner. “Culture of echinoderm larvae through metamorphosis.” Methods in Cell Biology 74 (January 2004): 75–86. https://doi.org/10.1016/s0091-679x(04)74004-2.Full Text
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Rockman, Matthew V., Matthew W. Hahn, Nicole Soranzo, David B. Goldstein, and Gregory A. Wray. “Positive selection on a human-specific transcription factor binding site regulating IL4 expression.” Current Biology : Cb 13, no. 23 (December 2003): 2118–23. https://doi.org/10.1016/j.cub.2003.11.025.Full Text
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Romano, Laura A., and Gregory A. Wray. “Conservation of Endo16 expression in sea urchins despite evolutionary divergence in both cis and trans-acting components of transcriptional regulation.” Development (Cambridge, England) 130, no. 17 (September 2003): 4187–99. https://doi.org/10.1242/dev.00611.Full Text
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Wray, Gregory A., Matthew W. Hahn, Ehab Abouheif, James P. Balhoff, Margaret Pizer, Matthew V. Rockman, and Laura A. Romano. “The evolution of transcriptional regulation in eukaryotes.” Molecular Biology and Evolution 20, no. 9 (September 2003): 1377–1419. https://doi.org/10.1093/molbev/msg140.Full Text
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Hahn, Matthew W., Jason E. Stajich, and Gregory A. Wray. “The effects of selection against spurious transcription factor binding sites.” Molecular Biology and Evolution 20, no. 6 (June 2003): 901–6. https://doi.org/10.1093/molbev/msg096.Full Text
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Knott, K Emily, Elizabeth J. Balser, William B. Jaeckle, and Gregory A. Wray. “Identification of asteroid genera with species capable of larval cloning.” The Biological Bulletin 204, no. 3 (June 2003): 246–55. https://doi.org/10.2307/1543596.Full Text
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Wray, Gregory A. “Transcriptional regulation and the evolution of development.” The International Journal of Developmental Biology 47, no. 7–8 (January 2003): 675–84.
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Wray, G. A., and R. R. Strathmann. “Stasis, change, and functional constraint in the evolution of animal body plans, whatever they may be.” Vie Et Milieu 52, no. 4 (December 1, 2002): 189–99.
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Rockman, Matthew V., and Gregory A. Wray. “Abundant raw material for cis-regulatory evolution in humans.” Molecular Biology and Evolution 19, no. 11 (November 2002): 1991–2004. https://doi.org/10.1093/oxfordjournals.molbev.a004023.Full Text
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Bely, A. E., and G. A. Wray. “Getting a head in the world.” Natural History 10/02 (October 2002): 30–32.
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Wray, G. A. “Evolution of a well-characterized embryonic promoter: the Endo16 cis-regulatory system of sea urchins.” Developmental Biology 247, no. 2 (July 15, 2002): 519–519.Link to Item
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Abouheif, Ehab, and Gregory A. Wray. “Evolution of the gene network underlying wing polyphenism in ants.” Science (New York, N.Y.) 297, no. 5579 (July 2002): 249–52. https://doi.org/10.1126/science.1071468.Full Text
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Hahn, Matthew W., and Gregory A. Wray. “The g-value paradox.” Evolution & Development 4, no. 2 (March 2002): 73–75. https://doi.org/10.1046/j.1525-142x.2002.01069.x.Full Text
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Lowe, Christopher J., Laurie Issel-Tarver, and Gregory A. Wray. “Gene expression and larval evolution: changing roles of distal-less and orthodenticle in echinoderm larvae.” Evolution & Development 4, no. 2 (March 2002): 111–23. https://doi.org/10.1046/j.1525-142x.2002.01066.x.Full Text
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Lowe, C. J., L. Issel Tarver, and G. A. Wray. “Evolution of new developmental roles for orthodenticle and distal-less in the larvae of echinoderms.” Evolution & Development 4 (February 2002): 111–23.
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Wray, Gregory A. “Do convergent developmental mechanisms underlie convergent phenotypes?” Brain, Behavior and Evolution 59, no. 5–6 (January 2002): 327–36. https://doi.org/10.1159/000063566.Full Text
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Wray, Gregory A. “Dating branches on the tree of life using DNA.” Genome Biology 3, no. 1 (January 2002): REVIEWS0001. https://doi.org/10.1186/gb-2001-3-1-reviews0001.Full Text
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Stone, J. R., and G. A. Wray. “Rapid evolution of cis-regulatory sequences via local point mutations.” Molecular Biology and Evolution 18, no. 9 (September 2001): 1764–70. https://doi.org/10.1093/oxfordjournals.molbev.a003964.Full Text
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Bely, A. E., and G. A. Wray. “Evolution of regeneration and fission in annelids: insights from engrailed- and orthodenticle-class gene expression.” Development (Cambridge, England) 128, no. 14 (July 2001): 2781–91. https://doi.org/10.1242/dev.128.14.2781.Full Text
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Wray, Gregory A. “Resolving the Hox Paradox.” Science 292, no. 5525 (June 22, 2001): 2256–57. https://doi.org/10.1126/science.1060305.Full Text
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Wray, G. A. “A world apart - The larval lifestyle may seem alien to us terrestrial bipeds, but it comes quite naturally to most creatures - especially inhabitants of the world's oceans.” Natural History 110, no. 2 (March 1, 2001): 52-+.Link to Item
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Stone, J. R., and G. A. Wray. “Rapid appearance of new transcription factor binding sites by local point mutation.” Molecular Biology and Evolution 18 (2001): 1764–70.
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Pizer, M., and G. A. Wray. “The evolution and development of left-right asymmetry in echinoderms.” American Zoologist 40, no. 6 (December 1, 2000): 1173–1173.Link to Item
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Wray, G. A. “The evolution of embryonic patterning mechanisms in animals.” Seminars in Cell & Developmental Biology 11, no. 6 (December 2000): 385–93. https://doi.org/10.1006/scdb.2000.0191.Full Text
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Cameron, R. A., G. Mahairas, J. P. Rast, P. Martinez, T. R. Biondi, S. Swartzell, J. C. Wallace, et al. “A sea urchin genome project: sequence scan, virtual map, and additional resources.” Proceedings of the National Academy of Sciences of the United States of America 97, no. 17 (August 2000): 9514–18. https://doi.org/10.1073/pnas.160261897.Full Text
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Wray, G. A. “Peering ahead (cautiously).” Evolution & Development 2, no. 3 (May 2000): 125–26. https://doi.org/10.1046/j.1525-142x.2000.00001.x.Full Text
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Wray, G. A., and C. J. Lowe. “Developmental regulatory genes and echinoderm evolution.” Systematic Biology 49, no. 1 (March 2000): 28–51. https://doi.org/10.1080/10635150050207375.Full Text
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Emily, K., and G. A. Wray. “Controversy and consensus in asteroid systernatics: New insights to ordinal and familial relationships.” American Zoologist 40, no. 3 (January 1, 2000): 382–92. https://doi.org/10.1093/icb/40.3.382.Full Text
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Lowe, C. J., and G. A. Wray. “Rearing larvae of sea urchins and sea stars for developmental studies.” Methods in Molecular Biology (Clifton, N.J.) 135 (January 2000): 9–15. https://doi.org/10.1385/1-59259-685-1:9.Full Text
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Wray, G. A. “The evolution of embryonic patterning mechanisms in animals.” Seminars in Cell and Developmental Biology 11 (2000): 353–93.
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Wray, G. A. “Peering ahead (cautiously).” Evolution and Development 2 (2000): 1–2.
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Wray, G. A. “Gene expression during echinoderm metamorphosis.” Zygote (Cambridge, England) 8 Suppl 1 (January 2000): S48–49.
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Wray, G. A., and C. J. Lowe. “Developmental regulatory genes and echinoderm evolution.” Systematic Biology 49 (2000): 151–74.
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Raff, R. A., W. Arthur, S. B. Carroll, M. I. Coates, and G. Wray. “Chronicling the birth of a discipline.” Evolution & Development 1, no. 1 (July 1999): 1–2. https://doi.org/10.1046/j.1525-142x.1999.00110.x.Full Text
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Abouheif, E., and G. A. Wray. “The evolutionary and developmental genetic basis of wing polymorphism in ants.” American Zoologist 39, no. 5 (January 1, 1999): 12A-12A.Link to Item
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Bely, A. E., and G. A. Wray. “Expression of homeobox genes during regeneration and asexual reproduction in an annelid.” American Zoologist 39, no. 5 (January 1, 1999): 12A-12A.Link to Item
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Wray, G. A. “Evolutionary dissociations between homologous genes and homologous structures.” Novartis Foundation Symposium 222 (January 1999): 189–203. https://doi.org/10.1002/9780470515655.ch13.Full Text
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Wray, G. A., and E. Abouheif. “When is homology not homology?” Current Opinion in Genetics & Development 8, no. 6 (December 1998): 675–80. https://doi.org/10.1016/s0959-437x(98)80036-1.Full Text
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Lowe, C. J., and G. A. Wray. “Erratum: Radical alterations in the roles of homeobox genes during echinoderm evolution (Nature (1997) 389 (718-721)).” Nature 392, no. 6671 (March 5, 1998): 105. https://doi.org/10.1038/32217.Full Text
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Wray, G. A. “Promoter logic.” Science (New York, N.Y.) 279, no. 5358 (March 1998): 1871–72. https://doi.org/10.1126/science.279.5358.1871.Full Text
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Passini, M. A., A. L. Kurtzman, A. K. Canger, W. S. Asch, G. A. Wray, P. A. Raymond, and N. Schechter. “Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development.” Developmental Genetics 23, no. 2 (January 1998): 128–41. https://doi.org/10.1002/(sici)1520-6408(1998)23:2<128::aid-dvg5>3.0.co;2-8.Full Text
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Abouheif, E., M. Akam, W. J. Dickinson, P. W. Holland, A. Meyer, N. H. Patel, R. A. Raff, V. L. Roth, and G. A. Wray. “Homology and developmental genes.” Trends in Genetics : Tig 13, no. 11 (November 1997): 432–33. https://doi.org/10.1016/s0168-9525(97)01271-7.Full Text
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Lowe, C. J., and G. A. Wray. “Radical alterations in the roles of homeobox genes during echinoderm evolution.” Nature 389, no. 6652 (October 1997): 718–21. https://doi.org/10.1038/39580.Full Text
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Benink, H., G. Wray, and J. Hardin. “Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo.” Development (Cambridge, England) 124, no. 18 (September 1997): 3461–70. https://doi.org/10.1242/dev.124.18.3461.Full Text
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Panganiban, G., S. M. Irvine, C. Lowe, H. Roehl, L. S. Corley, B. Sherbon, J. K. Grenier, et al. “The origin and evolution of animal appendages.” Proceedings of the National Academy of Sciences of the United States of America 94, no. 10 (May 1997): 5162–66. https://doi.org/10.1073/pnas.94.10.5162.Full Text
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Craig, S. F., L. B. Slobodkin, G. A. Wray, and C. H. Biermann. “The 'paradox' of polyembryony: A review of the cases and a hypothesis for its evolution.” Evolutionary Ecology 11, no. 2 (January 1, 1997): 127–43. https://doi.org/10.1023/A:1018443714917.Full Text
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Wray, G. A. “Parallel evolution of nonfeeding larvae in echinoids.” Systematic Biology 45, no. 3 (January 1, 1996): 308–22. https://doi.org/10.1093/sysbio/45.3.308.Full Text
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Wray, G. A., J. S. Levinton, and L. H. Shapiro. “Molecular evidence for deep Precambrian divergences among metazoan phyla.” Science 274, no. 5287 (January 1, 1996): 568–81. https://doi.org/10.1126/science.274.5287.568.Full Text
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Craig, S. F., L. B. Slobodkin, and G. Wray. “The 'paradox' of polyembryony.” Trends in Ecology &Amp; Evolution 10, no. 9 (January 1, 1995): 371–72. https://doi.org/10.1016/S0169-5347(00)89138-7.Full Text
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Smith, A. B., D. T. J. Littlewood, and G. A. Wray. “Comparing patterns of evolution: larval and adult life history stages and ribosomal RNA of post-Palaeozoic echinoids.” Philosophical Transactions Royal Society of London, B 349, no. 1327 (January 1, 1995): 11–18. https://doi.org/10.1098/rstb.1995.0085.Full Text
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Wray, G. A. “Punctuated evolution of embryos.” Science 267, no. 5201 (January 1, 1995): 1115–16. https://doi.org/10.1126/science.267.5201.1115.Full Text
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Wray, G. A. “The evolution of cell lineage in echinoderms.” Integrative and Comparative Biology 34, no. 3 (December 1, 1994): 353–63. https://doi.org/10.1093/icb/34.3.353.Full Text
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Wray, G. A., and A. E. Bely. “The evolution of echinoderm development is driven by several distinct factors.” Development 120, no. SUPPL. (December 1, 1994): 97–106.
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Wray, G. A. “Developmental evolution: new paradigms and paradoxes.” Developmental Genetics 15, no. 1 (January 1994): 1–6. https://doi.org/10.1002/dvg.1020150102.Full Text
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Wray, G. A., and A. E. Bely. “The evolution of echinoderm development is driven by several distinct factors.” Development (Cambridge, England). Supplement, January 1994, 97–106.
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Wray, G. A. “Rates of evolution in developmental processes.” Integrative and Comparative Biology 32, no. 1 (December 1, 1992): 123–34. https://doi.org/10.1093/icb/32.1.123.Full Text
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Wray, G. A. “The evolution of larval morphology during the post-Paleozoic radiation of echinoids.” Paleobiology 18, no. 3 (January 1, 1992): 258–87. https://doi.org/10.1017/S0094837300010848.Full Text
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Wray, G. A. “Rates of evolution in developmental processes.” American Zoologist 32, no. 1 (1992): 123–34.
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Henry, J. J., G. A. Wray, and R. A. Raff. “Mechanism of an Alternate Type of Echinoderm Blastula Formation: The Wrinkled Blastula of the Sea Urchin Heliocidaris erythrogramma direct development/echinoderm development/morphogenesis/sea urchin embryos/wrinkled blastula.” Development, Growth &Amp; Differentiation 33, no. 4 (January 1, 1991): 317–28. https://doi.org/10.1111/j.1440-169X.1991.00317.x.Full Text
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Hernry, J. J., G. A. Wray, and R. A. Raff. “Mechanism of an alternate type of echinoderm blastula formation: The wrinkled blastula of the sea urchin Heliocidaris erythrogramma.” Development Growth and Differentiation 33, no. 4 (1991): 317–28.
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Wray, G. A., and R. A. Raff. “The evolution of developmental strategy in marine invertebrates.” Trends in Ecology and Evolution 6, no. 2 (January 1, 1991): 45–50. https://doi.org/10.1016/0169-5347(91)90121-D.Full Text
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Henry, J. J., G. A. Wray, and R. A. Raff. “The dorsoventral axis is specified prior to first cleavage in the direct developing sea urchin Heliocidaris erythrogramma.” Development (Cambridge, England) 110, no. 3 (November 1990): 875–84. https://doi.org/10.1242/dev.110.3.875.Full Text
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Wray, G. A., and R. A. Raff. “Novel origins of lineage founder cells in the direct-developing sea urchin Heliocidaris erythrogramma.” Developmental Biology 141, no. 1 (September 1990): 41–54. https://doi.org/10.1016/0012-1606(90)90100-w.Full Text
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Scott, L. B., W. J. Lennarz, R. A. Raff, and G. A. Wray. “The "lecithotrophic" sea urchin Heliocidaris erythrogramma lacks typical yolk platelets and yolk glycoproteins.” Developmental Biology 138, no. 1 (March 1990): 188–93. https://doi.org/10.1016/0012-1606(90)90188-o.Full Text
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Raff, R. A., B. A. Parr, A. L. Parks, and G. A. Wray. “Heterochrony and other mechanisms of radical evolutionary change in early development.” Evolutionary Innovations, January 1, 1990, 71–98.
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NIJHOUT, H. F., G. A. WRAY, and L. E. GILBERT. “An analysis of the phenotypic effects of certain colour pattern genes in Heliconius (Lepidoptera: Nymphalidae).” Biological Journal of the Linnean Society 40, no. 4 (January 1, 1990): 357–72. https://doi.org/10.1111/j.1095-8312.1990.tb00545.x.Full Text
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Henry, J. J., S. Amemiya, G. A. Wray, and R. A. Raff. “Early inductive interactions are involved in restricting cell fates of mesomeres in sea urchin embryos.” Developmental Biology 136, no. 1 (November 1989): 140–53. https://doi.org/10.1016/0012-1606(89)90137-1.Full Text
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Wray, G. A., and R. A. Raff. “Evolutionary modification of cell lineage in the direct-developing sea urchin Heliocidaris erythrogramma.” Developmental Biology 132, no. 2 (April 1989): 458–70. https://doi.org/10.1016/0012-1606(89)90242-x.Full Text
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Raff, R. A., and G. A. Wray. “Heterochrony: Developmental mechanisms and evolutionary results.” Journal of Evolutionary Biology 2, no. 6 (January 1, 1989): 409–34. https://doi.org/10.1046/j.1420-9101.1989.2060409.x.Full Text
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WRAY, G. A., and D. R. MCCLAY. “MOLECULAR HETEROCHRONIES AND HETEROTOPIES IN EARLY ECHINOID DEVELOPMENT.” Evolution 43, no. 4 (1989): 803–13. https://doi.org/10.2307/2409308.Full Text Link to Item
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Wray, G. A., and D. R. McClay. “The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells.” Development (Cambridge, England) 103, no. 2 (June 1988): 305–15. https://doi.org/10.1242/dev.103.2.305.Full Text
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NIJHOUT, H. F., and G. A. WRAY. “Homologies in the colour patterns of the genus Heliconius (Lepidoptera: Nymphalidae).” Biological Journal of the Linnean Society 33, no. 4 (January 1, 1988): 345–65. https://doi.org/10.1111/j.1095-8312.1988.tb00449.x.Full Text
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WRAY, G. A., and D. R. MCCLAY. “THE EMBRYONIC MESENCHYME IN A PRIMITIVE SEA-URCHIN, EUCIDARIS-TRIBULOIDES.” Journal of Cell Biology 103, no. 5 (November 1, 1986): A371–A371.Link to Item
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Frederik Nijhout, H., G. A. Wray, C. Kremen, and C. K. Teragawa. “Ontogeny, phylogeny and evolution of form: An algorithmic approach.” Systematic Zoology 35, no. 4 (January 1, 1986): 445–57. https://doi.org/10.2307/2413108.Full Text
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Nijhout, H. F., and G. A. Wray. “Homologies in the colour patterns of the genus Charaxes (Lepidoptera: Nymphalidae).” Biological Journal of the Linnean Society 28, no. 4 (January 1, 1986): 387–410. https://doi.org/10.1111/j.1095-8312.1986.tb01766.x.Full Text
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Book Sections
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Wray, Gregory A. “Extreme phenotypic divergence and the evolution of development.,” 146:79–112, 2022. https://doi.org/10.1016/bs.ctdb.2021.10.004.Full Text
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Wray, G. A. “Developmental Genes and the Evolution of Morphology.” In Palaeobiology II, 147–52, 2007. https://doi.org/10.1002/9780470999295ch.31.Full Text
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Conference Papers
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Babbitt, C. C., L. W. Pfefferle, G. E. Crawford, and G. A. Wray. “Evolution of gene expression network underlying a disease state.” In Integrative and Comparative Biology, 55:E7–E7. OXFORD UNIV PRESS INC, 2015.Link to Item
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Babbitt, Courtney C., and Gregory A. Wray. “Evolution of gene expression network underlying a disease state in humans and non-human primates.” In American Journal of Physical Anthropology, 156:74–74. WILEY-BLACKWELL, 2015.Link to Item
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Bauernfeind, Amy L., Michelle L. Reyzer, Richard M. Caprioli, John J. Ely, Courtney C. Babbitt, Gregory A. Wray, Patrick R. Hof, and Chet C. Sherwood. “Differences in energy metabolism in the brains of humans and chimpanzees: a study of protein expression.” In American Journal of Physical Anthropology, 156:80–80. WILEY-BLACKWELL, 2015.Link to Item
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Bauernfeind, Amy L., Erik J. Soderblom, Meredith E. Turner, Arthur M. Moseley, John J. Ely, Patrick R. Hof, Chet C. Sherwood, Gregory A. Wray, and Courtney C. Babbitt. “Differential gene and protein expression in the human and chimpanzee brain: A comparison using high-throughput techniques.” In American Journal of Physical Anthropology, 153:73–73. WILEY-BLACKWELL, 2014.Link to Item
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Wygoda, J. A., D. Koop, J. Yang, G. A. Wray, and M. Byrne. “Developmental Transcriptome of Heliociaris erythrogramma - from bilateral larva to radial juvenile.” In Integrative and Comparative Biology, 54:E372–E372. OXFORD UNIV PRESS INC, 2014.Link to Item
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Wygoda, J. A., M. Byrne, D. R. Mcclay, and G. A. Wray. “Shifts in the Expression of Developmental Regulatory Genes Involved in the Evolution of a Novel Life History Difference.” In Integrative and Comparative Biology, 54:E230–E230. OXFORD UNIV PRESS INC, 2014.Link to Item
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Runcie, D. E., D. A. Garfield, C. C. Babbitt, A. Pfefferle, W. J. Nielsen, and G. A. Wray. “Phenotypic plasticity and the developmental regulatory network in the purple sea urchin.” In Echinoderms in a Changing World, edited by C. Johnson, 300–301. CRC PRESS-TAYLOR & FRANCIS GROUP, 2013.Link to Item
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Wray, G. A., D. Garfield, and D. Runcie. “Evolution of an embryonic gene regulatory network in the sea urchin Strongylocentrotus purpuratus.” In Echinoderms in a Changing World, edited by C. Johnson, 276–276. CRC PRESS-TAYLOR & FRANCIS GROUP, 2013.Link to Item
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Babbitt, C. C., L. W. Pfefferle, O. Fedrigo, and G. A. Wray. “Conservation and function of noncoding RNAs in primate evolution.” In Integrative and Comparative Biology, 52:E8–E8. OXFORD UNIV PRESS INC, 2012.Link to Item
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Horvath, Julie E., Christine Wu, Maxx Toler, Olivier Fedrigo, Lisa W. Pfefferle, Anthony Moore, Gowri L. Ramachandran, et al. “Enamel thickness in Microcebus murinus and Macaca mulana and the evolutionary genetics of enamel matrix proteins in hominoids.” In American Journal of Physical Anthropology, 147:168–168. WILEY-BLACKWELL, 2012.Link to Item
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Tung, Jenny, S. C. Alberts, and G. A. Wray. “Evolution of functional genetic variation at immune loci in wild baboons.” In American Journal of Physical Anthropology, 231–231. WILEY-LISS, 2010.Link to Item
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Wray, G. A. “Evolutionary mechanisms that operate on embryonic gene expression in purple sea urchin Strongylocentrotus purpuratus.” In Integrative and Comparative Biology, 44:668–668. OXFORD UNIV PRESS INC, 2004.Link to Item
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Wray, G. A. “The evolution of sea urchin development.” In Regulatory Processes in Development, edited by L. Olsson and C. O. Jacobson, 76:49–60. PORTLAND PRESS LTD, 2000.Link to Item
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Preprints
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Gartner, Valerie, Benjamin D. Redelings, Claudia Gaither, Jonathan B. Parr, Albert Kalonji, Fernandine Phanzu, Nicholas F. Brazeau, Jonathan J. Juliano, and Gregory A. Wray. “Genomic insights intoPlasmodium vivaxpopulation structure and diversity in central Africa.” Cold Spring Harbor Laboratory, December 19, 2022. https://doi.org/10.1101/2022.12.16.520826.Full Text
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- Teaching & Mentoring
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Recent Courses
- BIOLOGY 203L: Gateway to Biology: Molecular Biology, Genetics & Evolution 2023
- BIOLOGY 493: Research Independent Study 2023
- BIOLOGY 203L: Gateway to Biology: Molecular Biology, Genetics & Evolution 2022
- BIOLOGY 293: Research Independent Study 2022
- BIOLOGY 325: Current Technologies in Genomics and Precision Medicine 2022
- BIOLOGY 493: Research Independent Study 2022
- BIOLOGY 790S: Special Topics Seminar 2022
- BIOLOGY 799: Internship 2022
- BIOTRAIN 730: Data Visualization for Biomedical Sciences 2022
- MGM 325: Current Technologies in Genomics and Precision Medicine 2022
- BIOLOGY 203L: Gateway to Biology: Molecular Biology, Genetics & Evolution 2021
- BIOLOGY 293: Research Independent Study 2021
- BIOLOGY 325: Current Technologies in Genomics and Precision Medicine 2021
- BIOLOGY 493: Research Independent Study 2021
- BIOLOGY 750S: Introduction to Inclusion, Diversity, Equity, and Anti-Racism in Biology 2021
- MGM 325: Current Technologies in Genomics and Precision Medicine 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Departmental Seminar. Department of Biology. University of Pennsylvania. November 11, 2021 2021
- Developmental Biology of Sea Urchins. EchinoClub. June 18, 2021 2021
- COVID Seminar Series. Duke University School of Medicien. April 20, 2021 2021
- Departmental Seminar. Department of Genetics. University of Pennsylvania. March 18, 2021 2021
- Keynote. Genetics and Genomics Annual Retreat. North Carolina State University. August 29, 2020 2020
- Invited talk. Vertebrate Genomics Symposium. Cornell University. July 24, 2020 2020
- Program in Computational Biology and Bioinformatics, Duke University. December 5, 2013 2013
- International Society for Human Identification. October 8, 2013 2013
- Department of Biology. October 1, 2013 2013
- Instituto de Neurobiologia, Universidad Nacional Autonoma Mexico. August 1, 2013 2013
- Society for Molecular Biology and Evolution. July 9, 2013 2013
- Wenner-Gren/Swedish Royal Academies 10th Symposium. May 30, 2013 2013
- Department of Biological Sciences. March 4, 2013 2013
- Genomics to Systems Biology.. November 19, 2012 2012
- Houpt Lecture in Genome Sciences. September 28, 2012 2012
- Department of Biology. September 17, 2012 2012
- Society for Molecular Biology and Evolution. June 26, 2012 2012
- Mathematical Biosciences Institute. April 23, 2012 2012
- CARTA Conference. April 14, 2012 2012
- CARTA Public Symposium. April 13, 2012 2012
- Center for Comparative and Population Genetics. February 6, 2012 2012
- Department of Genetics. January 25, 2012 2012
- Department of Genetics, Yale University. May 3, 2011 2011
- Developmental Biology of the Sea Urchin. April 28, 2011 2011
- Keystone Symposium on Evolutionary Developmental Biology. February 28, 2011 2011
- Lausanne Genomics Days. February 18, 2011 2011
- Humans Without Borders: Evolutionary Processes at Work in Humans and Their Relatives. February 1, 2011 2011
- Banting and Best Department of Medical Research. University of Toronto, Canada. December 10, 2010 2010
- Evolutionary Applications in Medicine. NESCent. December 10, 2010 2010
- Systems Genetics. UNC Chapel Hill, Chapel Hill, NC. December 10, 2010 2010
- Frontiers in Genomics seminar. November 1, 2010 2010
- Annual Systematics Symposium. October 1, 2010 2010
- Evolution of Development. September 1, 2010 2010
- Canadian Society of Zoologists. May 1, 2010 2010
- Institute for Genomics & Systems Biology, Committee on Genetics Genomics & Systems Biology. April 1, 2010 2010
- Department of Biology, College of William & Mary. December 22, 2009 2009
- Department of Biology, University of North Carolina. December 22, 2009 2009
- European Molecular Biology Organization. December 22, 2009 2009
- Institute for Molecular Evolution, Penn State University. December 22, 2009 2009
- Darwin 2009 at Stony Brook. November 1, 2009 2009
- Koshland Lecture. November 1, 2009 2009
- Developmental Biology of Sea Urchins XVII. October 1, 2009 2009
- Titisee Conference on Genome Evolution. October 1, 2009 2009
- Keynote, Society for Molecular Biology and Evolution. June 1, 2009 2009
- The DNA Proteome. April 1, 2009 2009
- International Echinoderm Conference. January 1, 2009 2009
- Department of Genetics. December 1, 2008 2008
- Cis-regulatory Sequences and Their Evolution. October 1, 2008 2008
- Towards an Evolutionary Synthesis. July 1, 2008 2008
- Human Genome Research Institute. June 1, 2008 2008
- Developmental Biology of Sea Urchins XVI. April 1, 2008 2008
- Evolutionary Development Biology IGERT Conference. April 1, 2008 2008
- La Selva Research Station. April 1, 2008 2008
- Center for Systems Biology. March 1, 2008 2008
- Department of Genetics. March 1, 2008 2008
- Department of Biology. February 1, 2008 2008
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Outreach & Engaged Scholarship
- Bass Connections Faculty Team Member. Enabling Precision Health and Medicine. August 2017 - May 2018 2017 - 2018
- Workshop presentation, "Making Evolution Real and Relevant in the Classroom". Science Teacher Workshop, sponsored by NCABR. November 1, 2011 2011
- Unknown. Faculty of 1000. May 1, 2009 2009
- Unknown. Scientific Advisory Board, Office of Tropical Studies. December 15, 2008 2008
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Service to the Profession
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.